Base de dados : MEDLINE
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[PMID]:29466146
[Au] Autor:Feller-Kopman D; Light R
[Ad] Endereço:From the Division of Pulmonary, Critical Care, and Sleep Medicine, Johns Hopkins University, Baltimore (D.F.-K.); and the Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville (R.L.).
[Ti] Título:Pleural Disease.
[So] Source:N Engl J Med;378(8):740-751, 2018 02 22.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Empiema Pleural/terapia
Pleura/fisiopatologia
Derrame Pleural Maligno/terapia
Derrame Pleural/fisiopatologia
Pneumotórax/terapia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Empiema Pleural/diagnóstico
Empiema Pleural/fisiopatologia
Exsudatos e Transudatos/fisiologia
Seres Humanos
Pleura/anatomia & histologia
Derrame Pleural/diagnóstico
Derrame Pleural/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1403503


  2 / 14357 MEDLINE  
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[PMID]:29390341
[Au] Autor:Li M; Zhu W; Khan RSU; Saeed U; Wang R; Shi S; Luo Z
[Ad] Endereço:Department of Respiratory Medicine.
[Ti] Título:Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy: A PRISMA-compliant meta-analysis.
[So] Source:Medicine (Baltimore);96(50):e9205, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The concentration of interleukin-27 (IL-27) in pleural effusions was found to be increased in tuberculous pleurisy and several studies have investigated the diagnostic value of IL-27 for tuberculous pleural effusions (TPEs), but the results varied a lot. We conducted the present study to comprehensively evaluate the diagnostic value of IL-27 for TPE. METHODS: Primary diagnostic test studies of IL-27 for TPE was searched and identified from databases. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ration, diagnostic odds ratio, and receiver operating characteristic curves (SROCs) were computed or pooled to summarize the overall test performance. RESULTS: Nine studies with a total number of 1226 patients were identified in our research. The main pooled estimates were as follows: sensitivity 0.92 [95% confidence interval (CI), 0.90-0.95], specificity 0.90 (95% CI, 088-0.92), and area under the SROC 0.97. No evidence of publication bias was detected. CONCLUSION: Our research suggested the good diagnostic value of IL-27 for TPE and it could be used as a diagnostic biomarker.
[Mh] Termos MeSH primário: Interleucina-27/análise
Derrame Pleural/diagnóstico
Tuberculose Pleural/diagnóstico
[Mh] Termos MeSH secundário: Biomarcadores/análise
Seres Humanos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Biomarkers); 0 (Interleukin-27)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009205


  3 / 14357 MEDLINE  
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[PMID]:29390299
[Au] Autor:Guo F; Wu J; Peng Y; Tu M; Xiao B; Dai C; Jiang K; Gao W; Li Q; Wei J; Chen J; Xi C; Lu Z; Miao Y
[Ad] Endereço:Pancreas Center, First Affiliated Hospital.
[Ti] Título:Black pleural effusion due to pancreatic pseudocyst: A case report.
[So] Source:Medicine (Baltimore);96(50):e9043, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Black pleural effusion (BPE) is an extremely uncommon type of pleural fluid, which can be due to infection, primary or metastatic malignancy, and hemorrhage. As reported in previous studies, BPE is also observed in some patients with pancreatic pseudocyst. PATIENT CONCERNS: We herein reported a case of a 14-year-old female patient who was admitted to our center with a history of cough for 1 and a half months and right chest pain for 1 month. Before this, she was consecutively hospitalized in 3 different hospitals due to the same symptoms. However, the previous treatments were ineffective due to the lack of a definitive diagnosis. Laboratory examination of the pleural effusion showed BPE with a high amylase concentration. Chest x-ray and computed tomography (CT) showed massive pleural effusion, more prominent in the right chest. CT and MRCP of the abdomen showed a cystic lesion located in the tail of the pancreas, which entered the chest cavity via an esophageal hiatal hernia. DIAGNOSES:: pancreatic pseudocyst. INTERVENTIONS: After confirming that the tumor was a pancreatic pseudocyst by intraoperative biopsy, internal drainage to the jejunum was performed. OUTCOMES: The postoperative recovery was rapid and without complications, and the final discharge diagnosis was idiopathic pancreatic pseudocyst (without history of pancreatitis or pancreatic injuries) with BPE of the right chest. LESSONS: This case demonstrates that massive BPE could present as a rare complication of pancreatic pseudocyst, and surgery is a potential treatment for such patients.
[Mh] Termos MeSH primário: Pseudocisto Pancreático/complicações
Pseudocisto Pancreático/diagnóstico
Derrame Pleural/diagnóstico
Derrame Pleural/etiologia
[Mh] Termos MeSH secundário: Adolescente
Diagnóstico Diferencial
Diagnóstico por Imagem
Feminino
Seres Humanos
Pseudocisto Pancreático/cirurgia
Derrame Pleural/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009043


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[PMID]:28449653
[Au] Autor:Diawara I; Zerouali K; Elmdaghri N; Abid A
[Ad] Endereço:Laboratoire de Microbiologie, Faculté de Médecine et de Pharmacie, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco. diawaraidris@gmail.com.
[Ti] Título:A case report of parapneumonic pleural effusion caused by Streptococcus pneumoniae serotype 19A in a child immunized with 13-valent conjugate pneumococcal vaccine.
[So] Source:BMC Pediatr;17(1):114, 2017 Apr 27.
[Is] ISSN:1471-2431
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Simple parapneumonic effusion is a pleural effusion associated with lung infection (i.e., pneumonia). Streptococcus pneumoniae remains the most common pathogen causing parapneumonic effusions. In Morocco, the pneumococcal conjugate vaccine 13-valent (PCV13) was introduced in the national immunization program in October 2010 in 2 + 1 schedule for prevention of pneumococcal disease, and replaced by the PCV10 in July 2012 in the same schedule. We report a case of parapneumonic pleural effusions caused by S. pneumoniae serotype 19A in a child immunized with 3 doses of PCV13. CASE PRESENTATION: This is a 2.5 years old previously healthy Moroccan female, fully vaccinated by PCV13 and immunocompetent, admitted to a private medical clinic with a six months history of persistent asthma. On arrival (7 February 2015), she was febrile to 40.3 °C with a brutal flu syndrome, chills, dry cough and serous rhinitis, for which she received symptomatic treatment. A biological assessment was done that confirmed the clinical diagnosis of flu. Seven days after, she presented a progressive deterioration of its general condition and the onset of severe abdominal pain. She was hospitalized and a second biological assessment, computed tomography scans and chest radiography were done that confirmed a diagnosis of a pneumococcal parapneumonia with abscess of the left lower lobe with encysted empyema. Microbiological analysis of the pleural fluid showed a S. pneumoniae serotype 19A with susceptibility intermediate to penicillin. The patient was treated by antibiotics including amoxicillin, cefixime ceftriaxone and vancomycin. CONCLUSIONS: We reported a case of parapneumonic pleural effusions caused by a vaccine serotype pneumococcal 19A occurring in an immunocompetent child immunized with 3 doses of PCV13.
[Mh] Termos MeSH primário: Derrame Pleural/microbiologia
Vacinas Pneumocócicas
Pneumonia Pneumocócica/microbiologia
Sorogrupo
Streptococcus pneumoniae/imunologia
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Derrame Pleural/diagnóstico
Pneumonia Pneumocócica/diagnóstico
Pneumonia Pneumocócica/prevenção & controle
Streptococcus pneumoniae/isolamento & purificação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (13-valent pneumococcal vaccine); 0 (Pneumococcal Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1186/s12887-017-0872-2


  5 / 14357 MEDLINE  
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[PMID]:29254301
[Au] Autor:Shu M; Wang BY; Zhang J; Guo CY; Wang XH
[Ad] Endereço:Orthopedic Surgery Section 4, the 2nd Affiliated of Harbin Medical University, Harbin, China.
[Ti] Título:Analysis of specialized nursing on respiratory functions in thoracotomy patients.
[So] Source:J Biol Regul Homeost Agents;31(4):971-976, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:To analyze the nursing effect on the respiratory function of thoracotomy patients, sixty thoracotomy hospitalized patients were studied. The subjects were divided into a normal group (A) and an observation group (B). The patients in group A received routine nursing only, while those in group B received chest physiotherapy as well as routine nursing. Afterwards, the respiratory function indicators of the two groups were compared and a data analysis was performed. The results showed that the partial pressure of oxygen (PO2) value of the patients in group B was greater than that of the patients in group A while the partial pressure of carbon dioxide (PCO2) value in group B was smaller than that in group A, and there was a significant difference between the two groups (p less than 0.05). The vital capacity under normal circumstances and forced breathing of group B were greater than that of group A and the difference was statistically significant (p less than 0.05). The incidence of complications (atelectasis, respiratory infections, pleural effusion) was statistically significant between the two groups (p less than 0.05). The degree of autonomic respiratory dysfunction in group B was lower than that in group A, and there was a significant difference (p less than 0.05), suggesting that the respiratory function in patients receiving chest physiotherapy improved significantly.
[Mh] Termos MeSH primário: Exercícios Respiratórios/métodos
Drenagem Postural/métodos
Enfermagem em Pós-Anestésico/métodos
Enfermagem em Reabilitação/métodos
Toracotomia/reabilitação
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Massagem/métodos
Meia-Idade
Derrame Pleural/etiologia
Derrame Pleural/prevenção & controle
Atelectasia Pulmonar/etiologia
Atelectasia Pulmonar/prevenção & controle
Respiração
Testes de Função Respiratória
Infecções Respiratórias/etiologia
Infecções Respiratórias/prevenção & controle
Toracotomia/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  6 / 14357 MEDLINE  
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[PMID]:29208258
[Au] Autor:Martirossian A; Shah S; Carrete L; Valle J; Valentine V
[Ad] Endereço:Department of Internal Medicine (AM, LC), University of Texas Medical Branch, Galveston, Texas; Department of Internal Medicine, Division of Pulmonary Critical Care & Sleep Medicine (SS, JV), University of Texas Medical Branch, Galveston, Texas; Department of Internal Medicine, Division of Pulmo
[Ti] Título:Durability of Sirolimus for Lymphangioleiomyomatosis.
[So] Source:Am J Med Sci;354(6):603-607, 2017 12.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lymphangioleiomyomatosis (LAM), a rare, multisystem disorder primarily affecting women of reproductive age, is characterized by cystic-appearing lung lesions, progressive loss of lung function, chylous effusions and renal angiomyolipomas. Sirolimus, an mammalian target of rapamycin inhibitor, has been shown to stabilize lung function, reduce symptoms and resolve chylous effusions in the short term for patients with LAM. Herein, we report a premenopausal female with LAM who experienced complete and durable resolution of her chylothoraces with significant and sustained improvement in lung function on sirolimus.
[Mh] Termos MeSH primário: Antibióticos Antineoplásicos/uso terapêutico
Neoplasias Pulmonares/tratamento farmacológico
Linfangioleiomiomatose/tratamento farmacológico
Sirolimo/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Neoplasias Pulmonares/complicações
Neoplasias Pulmonares/diagnóstico por imagem
Linfangioleiomiomatose/complicações
Linfangioleiomiomatose/diagnóstico por imagem
Imagem por Ressonância Magnética
Derrame Pleural/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); W36ZG6FT64 (Sirolimus)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  7 / 14357 MEDLINE  
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[PMID]:28453379
[Au] Autor:Han M; Afshar Y; Chon AH; Scibetta E; Rao R; Chmait RH
[Ad] Endereço:a Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , University of California , Los Angeles, Los Angeles , California , USA.
[Ti] Título:Pseudoamniotic Band Syndrome Post Fetal Thoracoamniotic Shunting for Bilateral Hydrothorax.
[So] Source:Fetal Pediatr Pathol;36(4):311-318, 2017 Aug.
[Is] ISSN:1551-3823
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Pseudoamniotic band syndrome (PABS) occurs iatrogenically after fetal surgery or amniocentesis due to chorioamniotic membrane separation. Separation of the amnion from the chorion can expand to form fibrous amniotic bands that can envelope fetal limbs or the umbilical cord, with consequences ranging from limb constriction to fetal demise. CASE REPORT: We report a case of bilateral fetal pleural effusions at 27 weeks' gestation treated by bilateral thoracoamniotic shunts. Following shunt placement, the hydrothorax resolved. However, chorioamniotic membrane separation developed resulting in PABS with subsequent umbilical cord strangulation and fetal demise at 32 weeks' gestation. CONCLUSION: PABS has been previously described in the literature following various fetal interventions. This is the first reported case of pseudoamniotic band syndrome after placement of fetal thoracoamniotic shunts. A high index of suspicion is required to diagnose PABS via postoperative ultrasound. Post intervention chorioamniotic membrane separation warrants close surveillance for sonographic evidence of PABS.
[Mh] Termos MeSH primário: Síndrome de Bandas Amnióticas/etiologia
Quilotórax/congênito
Terapias Fetais/efeitos adversos
Hidropisia Fetal/cirurgia
[Mh] Termos MeSH secundário: Quilotórax/cirurgia
Feminino
Morte Fetal
Feto
Seres Humanos
Derrame Pleural/cirurgia
Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/15513815.2017.1313915


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[PMID]:28468865
[Au] Autor:Husain H; Nykin D; Bui N; Quan D; Gomez G; Woodward B; Venkatapathy S; Duttagupta R; Fung E; Lippman SM; Kurzrock R
[Ad] Endereço:Division of Hematology and Oncology, University of California San Diego, San Diego, California. hhusain@ucsd.edu.
[Ti] Título:Cell-Free DNA from Ascites and Pleural Effusions: Molecular Insights into Genomic Aberrations and Disease Biology.
[So] Source:Mol Cancer Ther;16(5):948-955, 2017 May.
[Is] ISSN:1538-8514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Collection of cell-free DNA (cfDNA) from the blood of individuals with cancer has permitted noninvasive tumor genome analysis. Detection and characterization of cfDNA in ascites and pleural effusions have not yet been reported. Herein, we analyzed cfDNA in the ascites and pleural effusions from six individuals with metastatic cancer. In all cases, cfDNA copy number variations (CNV) were discovered within the effusate. One individual had a relevant alteration with a high copy amplification in in a never smoker with lung cancer, who showed only and amplification in a prior tissue biopsy. Another subject with metastatic breast cancer had cytology-positive ascites and an activating mutation identified in the tissue, blood, and ascites collectively. This individual had tumor regression after the administration of the mTOR inhibitor everolimus and had evidence of chromotripsis from chromosomal rearrangements noted in the cell-free ascitic fluid. These results indicate that cfDNA from ascites and pleural effusions may provide additional information not detected with tumor and plasma cell-free DNA molecular characterization, and a context for important insights into tumor biology and clonal dynamic change within primary tumor and metastatic deposits. .
[Mh] Termos MeSH primário: Ascite/genética
Ácidos Nucleicos Livres/genética
Genoma Humano/genética
Neoplasias/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Ascite/sangue
Linhagem Celular Tumoral
Ácidos Nucleicos Livres/sangue
Classe I de Fosfatidilinositol 3-Quinases/genética
Quinase 4 Dependente de Ciclina/genética
Variações do Número de Cópias de DNA/genética
Feminino
Seres Humanos
Masculino
Meia-Idade
Mutação
Neoplasias/sangue
Neoplasias/classificação
Neoplasias/patologia
Derrame Pleural/genética
Proteínas Proto-Oncogênicas c-mdm2/genética
Receptor do Fator de Crescimento Epidérmico/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell-Free Nucleic Acids); EC 2.3.2.27 (MDM2 protein, human); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2); EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (PIK3CA protein, human); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.22 (CDK4 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1158/1535-7163.MCT-16-0436


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[PMID]:29443793
[Au] Autor:Huang J; Yu Y; Lin W; Zhang D; Deng Z; Ding Q
[Ad] Endereço:Department of Pharmacy, The Affiliated Hospital of Medical School of Ningbo University.
[Ti] Título:Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion: A case report.
[So] Source:Medicine (Baltimore);97(7):e9996, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Eosinophilic pleural effusion (EPE) is an eosinophil count ≥10% in pleural effusion, which is a rare condition in drug therapy. PATIENT CONCERNS: We describe the case of a 70-year-old Alzheimer patient who was taking olanzapine for 2 months for the treatment of depression, and developed peripheral eosinophilia and bilateral EPE. DIAGNOSES: Olanzapine-induced peripheral eosinophilia and eosinophilic pleural effusion was diagnosed. INTERVENTIONS: Olanzapine was discontinued, and repeated drainage of fluid from the pleural cavity was performed. OUTCOMES: All symptoms-as well as the EPE-were resolved 6 months later. LESSONS: This case is a reminder that olanzapine may be a potential agent for EPE, and that this should be considered in clinical practice.
[Mh] Termos MeSH primário: Antidepressivos/efeitos adversos
Benzodiazepinas/efeitos adversos
Eosinofilia/induzido quimicamente
Derrame Pleural/induzido quimicamente
[Mh] Termos MeSH secundário: Idoso
Depressão/tratamento farmacológico
Drenagem
Seres Humanos
Masculino
Derrame Pleural/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 12794-10-4 (Benzodiazepines); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009996


  10 / 14357 MEDLINE  
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[PMID]:29381918
[Au] Autor:Xu HY; Li CY; Su SS; Yang L; Ye M; Ye JR; Ke PP; Chen CS; Xie YP; Li YP
[Ad] Endereço:Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.
[Ti] Título:Diagnosis of tuberculous pleurisy with combination of adenosine deaminase and interferon-γ immunospot assay in a tuberculosis-endemic population: A prospective cohort study.
[So] Source:Medicine (Baltimore);96(47):e8412, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to identify the optimal cut-off value of T cell enzyme-linked immunospot assay for tuberculosis (T-SPOT.TB) and evaluate its diagnostic performance alone (in the peripheral blood) or in combination with the adenosine deaminase (ADA) activity test (in peripheral blood and the pleural fluid) in patients with tuberculous pleurisy.Adult patients presenting with pleural effusion were included in this prospective cohort study. Tuberculous pleurisy was diagnosed by T-SPOT.TB in peripheral blood and a combination of T-SPOT.TB and ADA activity test in pleural fluid and peripheral blood. Receiver operating characteristic (ROC) curve in combination with multivariate logistic regression was used to evaluate the diagnostic performance of the assays.Among a total of 189 patients with suspected tuberculous pleurisy who were prospectively enrolled in this study, 177 patients were validated for inclusion in the final analysis. ROC analysis revealed that the area under the ROC curve (AUC) for T-SPOT.TB in pleural fluid and peripheral blood was 0.918 and 0.881, respectively, and for the ADA activity test in pleural fluid was 0.944. In addition, 95.5 spot-forming cells (SFCs)/2.5 × 10 cells were determined as the optimal cut-off value for T-SPOT.TB in pleural fluid. Parallel combination of T-SPOT.TB and ADA activity test in pleural fluid showed increased sensitivity (96.9%) and specificity (87.5%), whereas serial combination showed increased specificity (97.5%). The combination of 3 assays had the highest sensitivity at 97.9%, with an AUC value of 0.964.T-SPOT.TB in pleural fluid performed better than that in peripheral blood and the ADA activity test in pleural fluid for tuberculous pleurisy diagnosis. The optimal cut-off value of T-SPOT.TB in pleural fluid was 95.5 SFCs/2.5 × 10 cells. Combination of 3 assays might be a promising approach for tuberculous pleurisy diagnosis.
[Mh] Termos MeSH primário: Adenosina Desaminase/imunologia
ELISPOT/métodos
Interferon gama/imunologia
Tuberculose Pleural/diagnóstico
Tuberculose Pleural/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
ELISPOT/normas
Feminino
Testes Hematológicos
Seres Humanos
Masculino
Meia-Idade
Derrame Pleural/imunologia
Estudos Prospectivos
Curva ROC
Valores de Referência
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
82115-62-6 (Interferon-gamma); EC 3.5.4.4 (Adenosine Deaminase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008412



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde