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[PMID]: 29499674 [Au] Autor: Casas P; Ascaso FJ; Vicente E; Tejero-Garcés G; Adiego MI; Cristóbal JA [Ad] Endereço: Department of Ophthalmology, Hospital Clínico Universitario "Lozano Blesa", San Juan Bosco 15, ES-50009, Zaragoza, Spain. paulacasaspascual@hotmail.com. [Ti] Título: Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls. [So] Source: BMC Ophthalmol;18(1):66, 2018 Mar 02. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination. [Mh] Termos MeSH primário: Fibras Nervosas/patologia Doenças do Nervo Óptico/etiologia Células Ganglionares da Retina/patologia Apneia Obstrutiva do Sono/complicações Transtornos da Visão/etiologia Campos Visuais [Mh] Termos MeSH secundário: Estudos de Casos e Controles Feminino Voluntários Saudáveis Seres Humanos Masculino Meia-Idade Doenças do Nervo Óptico/diagnóstico Estudos Prospectivos Apneia Obstrutiva do Sono/diagnóstico Tomografia de Coerência Óptica Transtornos da Visão/diagnóstico Testes de Campo Visual [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180304 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0728-z

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[PMID]: 29231011 [Au] Autor: Wu YD; Zhang LY; Cheng JD [Ad] Endereço: Zhongshan Medical School, Sun Yat-Sen University, Guangzhou 510080, China. [Ti] Título: [Research Progress of the Relationship between SUNDS and OSAHS]. [So] Source: Fa Yi Xue Za Zhi;33(1):52-57, 2017 Feb. [Is] ISSN: 1004-5619 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: Sudden unexplained nocturnal death syndrome （SUNDS） is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome （SAS） is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome （OSAHS） is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death. This article reviews the relationship between SUNDS and OSAHS and aims to provide new ideas for the pathogenesis of SUNDS. [Mh] Termos MeSH primário: Arritmias Cardíacas Síndrome de Brugada/patologia Morte Súbita/etiologia Apneia Obstrutiva do Sono/patologia [Mh] Termos MeSH secundário: Síndrome de Brugada/complicações Seres Humanos Masculino Apneia Obstrutiva do Sono/complicações [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180306 [Lr] Data última revisão: 180306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE [do] DOI: 10.3969/j.issn.1004-5619.2017.01.013

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[PMID]: 29273274 [Au] Autor: Saur JS; Brietzke SE [Ad] Endereço: Walter Reed National Military Medical Center, Bethesda, MD 20889, United States. [Ti] Título: Response to Letter to the Editor regarding article titled "Polysomnography results versus clinical factors to predict postoperative respiratory complications following pediatric adenotonsillectomy". [So] Source: Int J Pediatr Otorhinolaryngol;105:189-190, 2018 02. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Mh] Termos MeSH primário: Adenoidectomia Polissonografia [Mh] Termos MeSH secundário: Criança Seres Humanos Complicações Pós-Operatórias Período Pós-Operatório Apneia Obstrutiva do Sono/cirurgia Tonsilectomia [Pt] Tipo de publicação: LETTER; COMMENT [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171224 [St] Status: MEDLINE

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[PMID]: 29233563 [Au] Autor: Hsueh WY; Lee CF; Lee CH; Kang KT [Ad] Endereço: Department of Otolaryngology, Hsinchu Cathay General Hospital, Hsinchu, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Yuanpei University of Medical Technology, Department of Biomedical Engineering, Hsinchu, Taiwan. [Ti] Título: Polysomnography results versus clinical factors to predict post-operative respiratory complications following pediatric adenotonsillectomy. [So] Source: Int J Pediatr Otorhinolaryngol;105:187-188, 2018 02. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Mh] Termos MeSH primário: Adenoidectomia Polissonografia [Mh] Termos MeSH secundário: Criança Seres Humanos Complicações Pós-Operatórias Período Pós-Operatório Estudos Retrospectivos Apneia Obstrutiva do Sono/cirurgia Tonsilectomia [Pt] Tipo de publicação: LETTER; COMMENT [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171214 [St] Status: MEDLINE

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[PMID]: 28449901 [Au] Autor: McCarter SJ; St Louis EK; Sandness DJ; Duwell EJ; Timm PC; Boeve BF; Silber MH [Ad] Endereço: Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. [Ti] Título: Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. [So] Source: Sleep Med;33:23-29, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVES: We aimed to determine whether visual and automated rapid eye movement (REM) sleep without atonia (RSWA) methods could accurately diagnose patients with idiopathic REM sleep behavior disorder (iRBD) and comorbid obstructive sleep apnea (OSA). METHODS: In iRBD patients (n = 15) and matched controls (n = 30) with and without OSA, we visually analyzed RSWA phasic burst durations, phasic, tonic, and "any" muscle activity by 3-s mini-epochs, phasic activity by 30-s (AASM rules) epochs, and automated REM atonia index (RAI). Group RSWA metrics were analyzed with regression models. Receiver operating characteristic (ROC) curves were used to determine the best diagnostic cutoff thresholds for REM sleep behavior disorder (RBD). Both split-night and full-night polysomnographic studies were analyzed. RESULTS: All mean RSWA phasic burst durations and muscle activities were higher in iRBD patients than in controls (p <0.01). Muscle activity (phasic, "any") cutoffs for 3-s mini-epoch scorings were as follows: submentalis (SM) (15.8%, 19.5%), anterior tibialis (AT) (29.7%, 29.7%), and combined SM/AT (39.5%, 39.5%). The tonic muscle activity cutoff was 0.70% and RAI (SM) cutoff 0.86. The phasic muscle burst duration cutoffs were 0.66 s for SM and 0.71 s for AT. Combining phasic burst durations with RSWA muscle activity improved the sensitivity and specificity of iRBD diagnosis. CONCLUSIONS: This study provides evidence for quantitative RSWA diagnostic thresholds applicable in iRBD patients with OSA. Our findings in this study were very similar to those seen in patients with Parkinson's disease-REM sleep behavior disorder (PD-RBD), consistent with a common mechanism and presumed underlying etiology of synucleinopathy in both groups. [Mh] Termos MeSH primário: Tono Muscular/fisiologia Músculo Esquelético/fisiopatologia Transtorno do Comportamento do Sono REM/diagnóstico Apneia Obstrutiva do Sono/fisiopatologia Sono REM/fisiologia [Mh] Termos MeSH secundário: Idoso Comorbidade Eletromiografia/métodos Feminino Seres Humanos Masculino Meia-Idade Hipotonia Muscular/fisiopatologia Polissonografia/métodos Transtorno do Comportamento do Sono REM/complicações Transtorno do Comportamento do Sono REM/fisiopatologia Apneia Obstrutiva do Sono/complicações [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449900 [Au] Autor: Matsui K; Sasai-Sakuma T; Ishigooka J; Inoue Y [Ad] Endereço: Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan; Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan. [Ti] Título: Insufficient sleep rather than the apnea-hypopnea index can be associated with sleepiness-related driving problems of Japanese obstructive sleep apnea syndrome patients residing in metropolitan areas. [So] Source: Sleep Med;33:19-22, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) and insufficient sleep might increase the risk of drowsy driving and sleepiness-related vehicular accidents. This study retrospectively investigated the factors associated with these driving problems, particularly addressing OSAS severity and sleep amounts of affected drivers. METHODS: This study examined 161 patients (146 male and 15 female) with OSAS (apnea-hypopnea index [AHI] ≥ 5) who drove on a routine basis and who completed study questionnaires. To investigate factors associated with drowsy driving during the prior year and sleepiness-related vehicular accidents or near-miss events during the prior five years, logistic regression analyses were performed with age, body mass index, monthly driving distance, habitual sleep duration on weekdays, the Japanese version of Epworth Sleepiness Scale score, AHI, and periodic limb movement index as independent variables. RESULTS: Of the patients, 68 (42.2%) reported drowsy driving experiences, and 86 (53.4%) reported sleepiness-related vehicular accidents or near-miss events. Analyses revealed the following: older age (46-65 years, ≥66 years) was negatively associated with drowsy driving (p <0.05, p <0.05), and habitually shorter sleep duration on weekdays (≤6 hours) was positively associated with drowsy driving (p <0.01). Habitual sleep duration of ≤6 hours (p <0.01) and Epworth Sleepiness Scale score of ≥11 (p <0.01) were positively associated with sleepiness-related vehicular accidents and near-miss events. However, AHI was not associated with these driving problems. CONCLUSION: Insufficient sleep, rather than severity of OSAS, was associated with sleepiness-related driving problems in these Japanese OSAS patients. [Mh] Termos MeSH primário: Acidentes de Trânsito/estatística & dados numéricos Condução de Veículo/estatística & dados numéricos Distúrbios do Sono por Sonolência Excessiva/epidemiologia Apneia Obstrutiva do Sono/complicações Privação do Sono/fisiopatologia Fases do Sono/fisiologia [Mh] Termos MeSH secundário: Acidentes de Trânsito/prevenção & controle Adulto Idoso Distúrbios do Sono por Sonolência Excessiva/classificação Distúrbios do Sono por Sonolência Excessiva/fisiopatologia Feminino Seres Humanos Japão/epidemiologia Masculino Meia-Idade Polissonografia/métodos Estudos Retrospectivos Índice de Gravidade de Doença Apneia Obstrutiva do Sono/epidemiologia Privação do Sono/complicações Privação do Sono/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449895 [Au] Autor: El-Solh AA; Vermont L; Homish GG; Kufel T [Ad] Endereço: VA Western New York Healthcare System, Buffalo, NY, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University at Buffalo, Buffalo, USA; Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, USA. Electronic address: solh@buffalo.e [Ti] Título: The effect of continuous positive airway pressure on post-traumatic stress disorder symptoms in veterans with post-traumatic stress disorder and obstructive sleep apnea: a prospective study. [So] Source: Sleep Med;33:145-150, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVES: Previous retrospective studies have shown that continuous positive airway pressure (CPAP) exerts salutary effect on post-traumatic stress disorder (PTSD) symptoms and nightmare distress. The relative magnitude of therapeutic benefits from CPAP and the strength of associations between duration of CPAP use and PTSD symptomatology are unknown. METHODS: A prospective cohort design involving 47 combat veterans with PTSD and documented obstructive sleep apnea (OSA) by overnight polysomnography. Epworth Sleepiness Scale (ESS) score, PTSD checklist-Military (PCL-M), Nightmare Distress Questionnaire (NDQ), and Nightmare Frequency Questionnaire (NFQ) were administered at baseline and 3 months after CPAP therapy. Objective adherence was assessed at the 3-month follow-up. RESULTS: Twenty-two veterans with mild-to-moderate PTSD (PCL-M score 17-59) and 18 with severe-to-very-severe PTSD (PCL-M score 60-85) completed the study. There was a dose-dependent response of PCL-M to duration of CPAP usage (r = 0.45; p = 0.003). Veterans with severe-to-very-severe PTSD had a larger improvement in PTSD symptoms (d = 0.65; p = 0.004) compared with those with mild-to-moderate PTSD (d = 0.47; p = 0.04). CPAP usage was the only significant predictor of overall subjective improvement in PTSD symptoms (OR 10.5; p = 0.01). Significant changes in NDQ and NFQ scores following 3 months of treatment were observed in veterans adherent to CPAP, but the correlations with duration of CPAP use were not statistically significant (r = 0.24; p = 0.13 and r = 0.13; p = 0.4, respectively). CONCLUSIONS: Improvement of PTSD symptoms in veterans with OSA was more pronounced with prolonged use of CPAP. Adherence to treatment was linked to abatement in nightmare distress and frequency. Future investigation of multimodal treatment, including behavioral intervention combined with CPAP, is warranted. [Mh] Termos MeSH primário: Pressão Positiva Contínua nas Vias Aéreas/métodos Apneia Obstrutiva do Sono/diagnóstico Apneia Obstrutiva do Sono/terapia Transtornos de Estresse Pós-Traumáticos/diagnóstico [Mh] Termos MeSH secundário: Adulto Idoso Sonhos/psicologia Feminino Seres Humanos Masculino Meia-Idade Polissonografia Prevalência Estudos Prospectivos Apneia Obstrutiva do Sono/complicações Apneia Obstrutiva do Sono/fisiopatologia Transtornos de Estresse Pós-Traumáticos/complicações Transtornos de Estresse Pós-Traumáticos/epidemiologia Transtornos de Estresse Pós-Traumáticos/terapia Resultado do Tratamento Veteranos/estatística & dados numéricos [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449892 [Au] Autor: Black J; Reaven NL; Funk SE; McGaughey K; Ohayon MM; Guilleminault C; Ruoff C [Ad] Endereço: Stanford University, Palo Alto, CA, USA; Jazz Pharmaceuticals, Palo Alto, CA, USA. Electronic address: jedblack@stanford.edu. [Ti] Título: Medical comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study. [So] Source: Sleep Med;33:13-18, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE/BACKGROUND: The objective of this study was to evaluate medical comorbidity patterns in patients with a narcolepsy diagnosis in the United States. PATIENTS/METHODS: This was a retrospective medical claims data analysis. Truven Health Analytics MarketScan® Research Databases were accessed to identify individuals ≥18 years of age with ≥1 diagnosis code for narcolepsy (International Classification of Diseases (ICD)-9, 347.0, 347.00, 347.01, 347.1, 347.10, or 347.11) continuously insured between 2006 and 2010, and controls without narcolepsy matched 5:1 on age, gender, region, and payer. Narcolepsy and control subjects were compared for frequency of comorbid conditions, identified by the appearance of >1 diagnosis code(s) mapped to a Clinical Classification System (CCS) level 1 category any time during the study period, and on specific subcategories, including recognized narcolepsy comorbidities of obstructive sleep apnea (OSA) and depression. RESULTS: The final study group included 9312 subjects with narcolepsy and 46,559 controls (each group: average age, 46.1 years; 59% female). As compared with controls, patients with narcolepsy showed a statistically significant excess prevalence in all the CCS multilevel categories, the only exceptions being conditions originating in the perinatal period and pregnancy/childbirth complications. The greatest excess prevalence in the narcolepsy cohort was seen for mental illness (31.1% excess prevalence; odds ratio (OR) 3.8, 95% confidence interval (CI) 3.6, 4.0), followed by diseases of the digestive system (21.4% excess prevalence; OR 2.7, 95% CI 2.5, 2.8) and nervous system/sense organs (excluding narcolepsy; 20.7% excess prevalence; OR 3.7, 95% CI 3.4, 3.9). CONCLUSIONS: In this claims analysis, a narcolepsy diagnosis was associated with a wide range of comorbid medical illness claims, at significantly higher rates than matched controls. [Mh] Termos MeSH primário: Comorbidade/tendências Efeitos Psicossociais da Doença Narcolepsia/complicações Narcolepsia/diagnóstico [Mh] Termos MeSH secundário: Adulto Bases de Dados Factuais Depressão/complicações Depressão/epidemiologia Feminino Seres Humanos Revisão da Utilização de Seguros Masculino Meia-Idade Narcolepsia/epidemiologia Polissonografia/métodos Prevalência Estudos Retrospectivos Apneia Obstrutiva do Sono/complicações Apneia Obstrutiva do Sono/epidemiologia Apneia Obstrutiva do Sono/fisiopatologia Estados Unidos/epidemiologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449889 [Au] Autor: Terzaghi M; Spelta L; Minafra B; Rustioni V; Zangaglia R; Pacchetti C; Manni R [Ad] Endereço: Unit of Sleep Medicine and Epilepsy, C. Mondino National Neurological Institute, Pavia, Italy. Electronic address: michele.terzaghi@mondino.it. [Ti] Título: Treating sleep apnea in Parkinson's disease with C-PAP: feasibility concerns and effects on cognition and alertness. [So] Source: Sleep Med;33:114-118, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: Obstructive sleep apnea (OSA) is highly prevalent in Parkinson disease (PD) and is known to contribute to cognitive impairment and daytime sleepiness. We investigated feasibility of continuous positive airway pressure treatment (CPAP) and its effects on subjective daytime sleepiness and cognitive profile in PD plus OSA subjects in a longitudinal three months follow up study. METHODS: Seventy (age 71.7 ± 7.6, disease duration 9.9 ± 12.3, UPDRS-III 33.7 ± 12.5, MMSE 25.3 ± 3.6; years of education 7.7 ± 3.2) out of 228 consecutive PD patients undergoing in-lab video-polysomnography were found to have obstructive sleep apnea. Thirty-six subjects accepted to titrate therapeutic CPAP. Video-polysomnography, neuropsychological battery evaluating different cognitive domains and subjective scales for daytime sleepiness were scheduled at baseline and after three months. All the patients were given educational informations relative to diagnosis of OSA and benefits of OSA treatment, and an individualized training with CPAP. RESULTS: Twenty-seven (75%) subjects dropped out of the study due to CPAP intolerance. No demographic or disease-related variables (in particular, severity of OSA), could be found between subjects who completed the study versus those who dropped out. Nine subjects completed the three-month follow up, and there were no significant changes in subjective sleepiness, neuropsychological scores and sleep structure (except for reduction in apnea/hypopnea index and a trend toward increase in stage N3 sleep). CONCLUSION: Our data show that feasibility of CPAP treatment can be significantly threatened by overall attrition rates. Further studies should consider well-structured adherence promoting interventions. The actual role of OSA as a determinant of the profile of subjective daytime sleepiness and cognition in PD, and the effects of CPAP in PD need to be further studied. [Mh] Termos MeSH primário: Atenção/fisiologia Cognição/fisiologia Disfunção Cognitiva/complicações Pressão Positiva Contínua nas Vias Aéreas/métodos Estudos de Viabilidade Doença de Parkinson/complicações Síndromes da Apneia do Sono/terapia Apneia Obstrutiva do Sono/terapia [Mh] Termos MeSH secundário: Idoso Disfunção Cognitiva/epidemiologia Disfunção Cognitiva/fisiopatologia Feminino Seguimentos Seres Humanos Masculino Meia-Idade Testes Neuropsicológicos/normas Doença de Parkinson/epidemiologia Doença de Parkinson/terapia Cooperação do Paciente Polissonografia/métodos Síndromes da Apneia do Sono/complicações Síndromes da Apneia do Sono/fisiopatologia Apneia Obstrutiva do Sono/complicações Apneia Obstrutiva do Sono/epidemiologia Apneia Obstrutiva do Sono/fisiopatologia Fases do Sono/fisiologia Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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[PMID]: 28449886 [Au] Autor: Prudon B; Hughes J; West S [Ad] Endereço: Department of Respiratory Medicine, University Hospital of North Tees, Stockton-on-Tees, UK. Electronic address: ben_prudon@doctors.org.uk. [Ti] Título: A novel postal-based approach to diagnosing obstructive sleep apnoea in a high-risk population. [So] Source: Sleep Med;33:1-5, 2017 May. [Is] ISSN: 1878-5506 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE: More than 50% of patients with diabetic macular oedema (DMO) have obstructive sleep apnoea (OSA), but the majority remain undiagnosed. We used a four-channel device (ApneaLink [AL], ResMed, UK) to establish a remote postal-based diagnostic service for patients with DMO. Here we describe our experience. METHODS: Patients with DMO were invited to participate. Interested patients returned a free-post reply slip to the study team, who posted an AL with pictorial and written instructions to them. Following a single night study, the AL was returned by a freepost service. RESULTS: Responses from 733 patients meeting the inclusion criteria were received, comprising 469 males and 264 females, mean age 64 years (standard deviation 10.4 years). ALs were issued to 718 patients, of whom 606 completed a diagnostic study. A total of 71 patients (12%) required a repeat study due to inadequacy of the first attempt. Completed sleep studies showed that 75% of respondents had sleep disordered breathing: 4% ODI 0-4/h, 24%; 5-9/h, 19%; 10-19/h, 23%; ≥20/h, 34%; and AHI 0-4/h, 25%; 5-14/h, 38%; 15-29/h, 20%; ≥30/h, 17%. Among 1592 postal events through the national post service, 20 ALs were lost. CONCLUSIONS: We have demonstrated that a remote postal-based diagnostic service for populations with a high risk of OSA can be successfully performed. This novel approach, which avoids clinic attendance, may be useful in clinical practice. [Mh] Termos MeSH primário: Retinopatia Diabética/complicações Polissonografia/instrumentação Apneia Obstrutiva do Sono/diagnóstico [Mh] Termos MeSH secundário: Idoso Complicações do Diabetes/fisiopatologia Retinopatia Diabética/epidemiologia Feminino Seres Humanos Edema Macular/patologia Masculino Meia-Idade Polissonografia/métodos Prevalência Fatores de Risco Síndromes da Apneia do Sono/epidemiologia Apneia Obstrutiva do Sono/epidemiologia Apneia Obstrutiva do Sono/fisiopatologia Reino Unido/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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