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[PMID]: | 28449892 |
[Au] Autor: | Black J; Reaven NL; Funk SE; McGaughey K; Ohayon MM; Guilleminault C; Ruoff C |
[Ad] Endereço: | Stanford University, Palo Alto, CA, USA; Jazz Pharmaceuticals, Palo Alto, CA, USA. Electronic address: jedblack@stanford.edu. |
[Ti] Título: | Medical comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study. |
[So] Source: | Sleep Med;33:13-18, 2017 May. | [Is] ISSN: | 1878-5506 |
[Cp] País de publicação: | Netherlands |
[La] Idioma: | eng |
[Ab] Resumo: | OBJECTIVE/BACKGROUND: The objective of this study was to evaluate medical comorbidity patterns in patients with a narcolepsy diagnosis in the United States. PATIENTS/METHODS: This was a retrospective medical claims data analysis. Truven Health Analytics MarketScan® Research Databases were accessed to identify individuals ≥18 years of age with ≥1 diagnosis code for narcolepsy (International Classification of Diseases (ICD)-9, 347.0, 347.00, 347.01, 347.1, 347.10, or 347.11) continuously insured between 2006 and 2010, and controls without narcolepsy matched 5:1 on age, gender, region, and payer. Narcolepsy and control subjects were compared for frequency of comorbid conditions, identified by the appearance of >1 diagnosis code(s) mapped to a Clinical Classification System (CCS) level 1 category any time during the study period, and on specific subcategories, including recognized narcolepsy comorbidities of obstructive sleep apnea (OSA) and depression. RESULTS: The final study group included 9312 subjects with narcolepsy and 46,559 controls (each group: average age, 46.1 years; 59% female). As compared with controls, patients with narcolepsy showed a statistically significant excess prevalence in all the CCS multilevel categories, the only exceptions being conditions originating in the perinatal period and pregnancy/childbirth complications. The greatest excess prevalence in the narcolepsy cohort was seen for mental illness (31.1% excess prevalence; odds ratio (OR) 3.8, 95% confidence interval (CI) 3.6, 4.0), followed by diseases of the digestive system (21.4% excess prevalence; OR 2.7, 95% CI 2.5, 2.8) and nervous system/sense organs (excluding narcolepsy; 20.7% excess prevalence; OR 3.7, 95% CI 3.4, 3.9). CONCLUSIONS: In this claims analysis, a narcolepsy diagnosis was associated with a wide range of comorbid medical illness claims, at significantly higher rates than matched controls. |
[Mh] Termos MeSH primário: |
Comorbidade/tendências Efeitos Psicossociais da Doença Narcolepsia/complicações Narcolepsia/diagnóstico
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[Mh] Termos MeSH secundário: |
Adulto Bases de Dados Factuais Depressão/complicações Depressão/epidemiologia Feminino Seres Humanos Revisão da Utilização de Seguros Masculino Meia-Idade Narcolepsia/epidemiologia Polissonografia/métodos Prevalência Estudos Retrospectivos Apneia Obstrutiva do Sono/complicações Apneia Obstrutiva do Sono/epidemiologia Apneia Obstrutiva do Sono/fisiopatologia Estados Unidos/epidemiologia
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[Pt] Tipo de publicação: | COMPARATIVE STUDY; JOURNAL ARTICLE |
[Em] Mês de entrada: | 1802 |
[Cu] Atualização por classe: | 180216 |
[Lr] Data última revisão:
| 180216 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170429 |
[St] Status: | MEDLINE |
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