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[PMID]:28453783
[Au] Autor:Ferré Á; Poca MA; de la Calzada MD; Moncho D; Romero O; Sampol G; Sahuquillo J
[Ad] Endereço:Clinical Neurophysiology Department, Barcelona, Spain.
[Ti] Título:Sleep-Related Breathing Disorders in Chiari Malformation Type 1: A Prospective Study of 90 Patients.
[So] Source:Sleep;40(6), 2017 Jun 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study objective: The aim of the present study is to describe the prevalence of sleep disorders in a large group of patients with Chiari malformation type 1 (CM-1) and determine the presence of risk factors associated with these abnormalities. Methods: Prospective study with consecutive patient selection. We included 90 adult patients with CM-1, defined by the presence of a cerebellar tonsillar descent (TD) ≥3 mm. Clinical, neuroradiological studies, and nocturnal polysomnography (PSG) was carried out. In addition, patients were also subclassified into 2 CM subtypes: CM-1, with the obex above the foramen magnum (FM) and CM-1.5, in which along with a TD ≥3 mm, the obex was located below the FM. Results: We observed a high prevalence (50%) of sleep-related breathing disorders (SRBDs) with predominant hypopnea. Only six patients showed a central apnea index of ≥5. Hypoventilation was observed in only three patients. SRBD severity was associated with male sex, older age, excess weight, and the presence of hydrocephalus. No differences in clinical or PSG parameters were found when comparing CM subtypes (CM-1 and CM-1.5). Sleep architecture study showed decreased sleep efficiency with an increase in arousal and waking after sleep onset. The presence of SRBDs was found to be associated with poorer sleep architecture parameters. Conclusions: This study confirms a high prevalence of SRBDs in patients with CM-1 and CM-1.5, with a predominant obstructive component. Nocturnal PSG recordings should be systematically conducted in these patients, especially those who are male, older, or overweight or those who present hydrocephalus.
[Mh] Termos MeSH primário: Malformação de Arnold-Chiari/epidemiologia
Dissonias/epidemiologia
Dissonias/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Malformação de Arnold-Chiari/classificação
Nível de Alerta
Feminino
Seres Humanos
Hidrocefalia/epidemiologia
Hipoventilação/epidemiologia
Masculino
Sobrepeso/epidemiologia
Polissonografia
Prevalência
Estudos Prospectivos
Fatores de Risco
Caracteres Sexuais
Síndromes da Apneia do Sono/epidemiologia
Síndromes da Apneia do Sono/fisiopatologia
Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx069


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[PMID]:28789478
[Au] Autor:Mishima T; Koga S; Lin WL; Kasanuki K; Castanedes-Casey M; Wszolek ZK; Oh SJ; Tsuboi Y; Dickson DW
[Ad] Endereço:Department of Neuroscience, Mayo Clinic, Jacksonville, Florida (TM, SK, W-LL, KK, MC-C, DWD); Department of Neurology, Fukuoka University, Fukuoka, Japan (TM, YT); Department of Neurology, Mayo Clinic, Jacksonville, Florida (ZKW); and Department of Neurology, University of Alabama at Birmingham, Bir
[Ti] Título:Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy.
[So] Source:J Neuropathol Exp Neurol;76(8):676-682, 2017 Aug 01.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Perry syndrome is a rare atypical parkinsonism with depression, apathy, weight loss, and central hypoventilation caused by mutations in dynactin p150glued (DCTN1). A rare distal hereditary motor neuropathy, HMN7B, also has mutations in DCTN1. Perry syndrome has TAR DNA-binding protein of 43 kDa (TDP-43) inclusions as a defining feature. Other TDP-43 proteinopathies include amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with and without motor neuron disease (FTLD-MND). TDP-43 forms aggregates in neuronal cytoplasmic inclusions (NCIs), neuronal intranuclear inclusions, dystrophic neurites (DNs), as well as axonal spheroids, oligodendroglial cytoplasmic inclusions, and perivascular astrocytic inclusions (PVIs). We performed semiquantitative assessment of these lesions and presence of dynactin subunit p50 lesions in 3 cases of Perry syndrome and one of HMN7B. We compared them with 3 cases of FTLD-MND, 3 of ALS, and 3 of hippocampal sclerosis (HpScl). Perry syndrome had NCIs, DNs, and frequent PVIs and spheroids. Perry syndrome cases were similar, but different from ALS, FTLD-MND, and HpScl. TDP-43 pathology was not detected in HMN7B. Dynactin p50 inclusions were observed in both Perry syndrome and HMN7B, but not in the other conditions. These results suggest that Perry syndrome may be distinctive type of TDP-43 proteinopathy.
[Mh] Termos MeSH primário: Tronco Encefálico/metabolismo
Proteínas de Ligação a DNA/genética
Hipoventilação/genética
Hipoventilação/patologia
Transtornos Parkinsonianos/genética
Transtornos Parkinsonianos/patologia
Proteinopatias TDP-43/classificação
Proteinopatias TDP-43/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Esclerose Amiotrófica Lateral/genética
Esclerose Amiotrófica Lateral/patologia
Tronco Encefálico/patologia
Tronco Encefálico/ultraestrutura
Proteínas de Ligação a DNA/metabolismo
Depressão/genética
Depressão/patologia
Complexo Dinactina/genética
Complexo Dinactina/metabolismo
Saúde da Família
Feminino
Seres Humanos
Masculino
Microscopia Imunoeletrônica
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DCTN1 protein, human); 0 (DCTN2 protein, human); 0 (DNA-Binding Proteins); 0 (Dynactin Complex); 0 (TDP-43 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1093/jnen/nlx049


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[PMID]:28408467
[Au] Autor:Wong W; Rosen D
[Ad] Endereço:Division of Respiratory Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
[Ti] Título:Isolated mild sleep-associated hypoventilation in children with Down syndrome.
[So] Source:Arch Dis Child;102(9):821-824, 2017 Sep.
[Is] ISSN:1468-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Children with Down syndrome (DS) have a high incidence of obstructive sleep apnea (OSA) that is often associated with hypoventilation. Little is known, however, about the prevalence of sleep-associated hypoventilation independent of OSA in these children. METHODS: Retrospective chart review of all children with DS under 18 years of age undergoing polysomnography at a tertiary care paediatric hospital during a 2-year period. Exclusion criteria were as follow: those requiring oxygen or positive-pressure ventilation; with tracheostomy, baseline hypoxia, unrepaired cyanotic heart disease, pulmonary hypertension, and cerebral palsy; or OSA with >5 obstructions/hour. RESULTS: 86 children met inclusion criteria. 68 (79%) had ETCO values >50 mm Hg during sleep. 37 (43%) ranged 50-55 mm Hg, and 12 (14%) met American Academy of Sleep Medicine criteria for hypoventilation of ETCO >50 mm Hg for >25% of total sleep time (TST). Average pulse-oximetry saturation (SpO ) values during sleep were 97.8% (SD ±1; range: 95.1-99.9). Average percentage of TST with SpO >92% was 99.89%. CONCLUSION: Mildly elevated ETCO in the absence of OSA is common in children with DS. This may reflect underlying differences in autonomic control of ventilation in these children and may be considered a normal variant not necessitating intervention other than close monitoring for pulmonary hypertension.
[Mh] Termos MeSH primário: Síndrome de Down/complicações
Hipoventilação/etiologia
Síndromes da Apneia do Sono/etiologia
[Mh] Termos MeSH secundário: Adolescente
Dióxido de Carbono/fisiologia
Criança
Pré-Escolar
Síndrome de Down/sangue
Feminino
Seres Humanos
Hipoventilação/sangue
Lactente
Masculino
Oxigênio/sangue
Pressão Parcial
Polissonografia
Estudos Retrospectivos
Síndromes da Apneia do Sono/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
142M471B3J (Carbon Dioxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2016-311694


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[PMID]:28371199
[Au] Autor:Cain JT; Kim DI; Quast M; Shivega WG; Patrick RJ; Moser C; Reuter S; Perez M; Myers A; Weimer JM; Roux KJ; Landsverk M
[Ad] Endereço:Children's Health Research Center, Sanford Research, Sioux Falls, South Dakota.
[Ti] Título:Nonsense pathogenic variants in exon 1 of PHOX2B lead to translational reinitiation in congenital central hypoventilation syndrome.
[So] Source:Am J Med Genet A;173(5):1200-1207, 2017 May.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pathogenic variants in PHOX2B lead to congenital central hypoventilation syndrome (CCHS), a rare disorder of the nervous system characterized by autonomic dysregulation and hypoventilation typically presenting in the neonatal period, although a milder late-onset (LO) presentation has been reported. More than 90% of cases are caused by polyalanine repeat mutations (PARMs) in the C-terminus of the protein; however non-polyalanine repeat mutations (NPARMs) have been reported. Most NPARMs are located in exon 3 of PHOX2B and result in a more severe clinical presentation including Hirschsprung disease (HSCR) and/or peripheral neuroblastic tumors (PNTs). A previously reported nonsense pathogenic variant in exon 1 of a patient with LO-CCHS and no HSCR or PNTs leads to translational reinitiation at a downstream AUG codon producing an N-terminally truncated protein. Here we report additional individuals with nonsense pathogenic variants in exon 1 of PHOX2B. In vitro analyses were used to determine if these and other reported nonsense variants in PHOX2B exon 1 produced N-terminally truncated proteins. We found that all tested nonsense variants in PHOX2B exon 1 produced a truncated protein of the same size. This truncated protein localized to the nucleus and transactivated a target promoter. These data suggest that nonsense pathogenic variants in the first exon of PHOX2B likely escape nonsense mediated decay (NMD) and produce N-terminally truncated proteins functionally distinct from those produced by the more common PARMs.
[Mh] Termos MeSH primário: Doença de Hirschsprung/genética
Proteínas de Homeodomínio/genética
Hipoventilação/congênito
Biossíntese de Proteínas
Apneia Central do Sono/genética
Fatores de Transcrição/genética
[Mh] Termos MeSH secundário: Códon sem Sentido/genética
Éxons/genética
Doença de Hirschsprung/patologia
Seres Humanos
Hipoventilação/genética
Hipoventilação/patologia
Mutação
Peptídeos/genética
Regiões Promotoras Genéticas
Sequências Repetitivas de Aminoácidos/genética
Apneia Central do Sono/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Nonsense); 0 (Homeodomain Proteins); 0 (NBPhox protein); 0 (Peptides); 0 (Transcription Factors); 25191-17-7 (polyalanine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.38162


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[PMID]:28288298
[Au] Autor:Somri M; Matter I; Hadjittofi C; Hoash N; Moaddi B; Kharouba J; Parisinos CA; Peretz B
[Ti] Título:Detection of Respiratory Adverse Events in Pediatric Dental Patients Sedated With 0.75mg/Kg of Midazolam and Oxygen by Continuous Pretracheal Auscultation: A Prospective Randomized Controlled Trial.
[So] Source:J Clin Pediatr Dent;41(2):154-160, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Sedation is becoming more commonplace for pediatric patients undergoing minor procedures. Fortunately, electronic monitors have contributed to a reduction in the associated respiratory adverse events (RAEs). To test the hypothesis that adding the pretracheal stethoscope (PTS) to standard monitoring methods (SMMs) may improve RAE detection in sedated pediatric dental patients, the frequency of RAEs detected by SMMs (i.e. visual observation, capnography, and pulse oximetry) was compared to that detected by SMMs alongside continuous PTS auscultation. STUDY DESIGN: A prospective, randomised, controlled trial was performed with 100 pediatric patient participants of ASA≤2, who were scheduled to receive dental treatment under 0.75 mg/kg and oxygen. Patients were randomised into Groups A (n=50; SMMs) and B (n=50; SMMs+PTS). Inclusion criteria were behavioral management problems and intolerance to dental treatment despite behavioral management techniques or nitrous oxide administration. Exclusion criteria were high-risk conditions for RAEs, altered mental status, gastrointestinal disorders, parental refusal of conscious sedation and failure of previous conscious sedation. An anesthesist was present throughout the dental treatments. RESULTS: RAEs were detected in 10 (20%) and 22(44%) Group A and B patients respectively (p=0.01). The majority of RAEs within Group B were detected by PTS auscultation (n=19). Capnography produced 13 and 15 false-positive results in Groups A and B respectively, whereas the PTS produced 4(8%) false-positive results in Group B (p=0.009). CONCLUSIONS: PTS was found to be useful for detecting RAEs during pediatric dental sedation with 0.75mg/kg midazolam and oxygen, in the presence of an anesthesist.
[Mh] Termos MeSH primário: Auscultação
Hipnóticos e Sedativos/administração & dosagem
Midazolam/administração & dosagem
Oxigênio/administração & dosagem
[Mh] Termos MeSH secundário: Obstrução das Vias Respiratórias/diagnóstico
Anestesia Dentária
Apneia/diagnóstico
Capnografia
Criança
Pré-Escolar
Feminino
Seres Humanos
Hipoventilação/diagnóstico
Laringismo/diagnóstico
Masculino
Oximetria
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Hypnotics and Sedatives); R60L0SM5BC (Midazolam); S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.2.154


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[PMID]:28246169
[Au] Autor:Li L; Ng NK; Koon AC; Chan HY
[Ad] Endereço:From the Laboratory of Drosophila Research.
[Ti] Título:Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor.
[So] Source:J Biol Chem;292(14):5784-5800, 2017 Apr 07.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Polyalanine (poly(A)) diseases are caused by the expansion of translated GCN triplet nucleotide sequences encoding poly(A) tracts in proteins. To date, nine human disorders have been found to be associated with poly(A) tract expansions, including congenital central hypoventilation syndrome and oculopharyngeal muscular dystrophy. Previous studies have demonstrated that unexpanded wild-type poly(A)-containing proteins localize to the cell nucleus, whereas expanded poly(A)-containing proteins primarily localize to the cytoplasm. Because most of these poly(A) disease proteins are transcription factors, this mislocalization causes cellular transcriptional dysregulation leading to cellular dysfunction. Correcting this faulty localization could potentially point to strategies to treat the aforementioned disorders, so there is a pressing need to identify the mechanisms underlying the mislocalization of expanded poly(A) protein. Here, we performed a glutathione -transferase pulldown assay followed by mass spectrometry and identified eukaryotic translation elongation factor 1 α1 (eEF1A1) as an interacting partner with expanded poly(A)-containing proteins. Strikingly, knockdown of expression partially corrected the mislocalization of the expanded poly(A) proteins in the cytoplasm and restored their functions in the nucleus. We further demonstrated that the expanded poly(A) domain itself can serve as a nuclear export signal. Taken together, this study demonstrates that eEF1A1 regulates the subcellular location of expanded poly(A) proteins and is therefore a potential therapeutic target for combating the pathogenesis of poly(A) diseases.
[Mh] Termos MeSH primário: Sinais de Exportação Nuclear
Fator 1 de Elongação de Peptídeos/metabolismo
Peptídeos/metabolismo
Expansão das Repetições de Trinucleotídeos
[Mh] Termos MeSH secundário: Células HEK293
Seres Humanos
Hipoventilação/congênito
Hipoventilação/genética
Hipoventilação/metabolismo
Distrofia Muscular Oculofaríngea/genética
Distrofia Muscular Oculofaríngea/metabolismo
Fator 1 de Elongação de Peptídeos/genética
Transporte Proteico/genética
Apneia Central do Sono/genética
Apneia Central do Sono/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (EEF1A1 protein, human); 0 (Nuclear Export Signals); 0 (Peptide Elongation Factor 1); 0 (Peptides); 25191-17-7 (polyalanine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.763599


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[PMID]:28202896
[Au] Autor:Kwak HJ; Lee JY; Wha Lee J; Kim HS; Hur HJ; Kim JY
[Ad] Endereço:Department of Anesthesiology and Pain Medicine, Gachon University, Gil Medical Center, Incheon, South Korea.
[Ti] Título:Effect of Mild Hypercapnia on Lung Oxygenation in Sitting Position During Shoulder Arthroscopy Under General Anesthesia.
[So] Source:Med Sci Monit;23:843-849, 2017 Feb 16.
[Is] ISSN:1643-3750
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Mild hypercapnia is permitted during surgeries in sitting position under general anesthesia to maintain cerebral regional oxygen saturation (rSO2). However, since hypoventilation may cause gas exchange impairment, we evaluated effects of mild hypercapnia on lung oxygenation during shoulder arthroscopy in sitting position. MATERIAL AND METHODS Forty patients were randomly allocated to a normocapnia group (ETCO2 35 mmHg, n=20) or a hypercapnia group (45 mmHg, n=20). The mean arterial pressure (MAP), heart rate (HR), and rSO2 were measured 5 min after intubation in supine position (T0), and at 2, 4, 6, 8, 10, 20, 30, 40, 50, and 60 min of remaining in sitting position (T1-10). Arterial blood gas was analyzed at T0 and T5. The oxygenation index (PaO2/FiO2) and dead-space ventilation ratio (Vd/Vt) were calculated. RESULTS There were no differences in PaO2/FiO2 at T0 and T5 between the 2 groups. At T5, the Vd/Vt was higher in the normocapnia group than in the hypercapnia group (p=0.04). The Vd/Vt at T5 increased from T0 in the normocapnia group. The incidence of cerebral desaturation in the hypercapnia group (0/20) was lower than in the normocapnia group (5/20) (p=0.047). Among rSO2, MAP, and HR, only changes in rSO2 over time between the 2 groups differed significantly (p=0.048). CONCLUSIONS Mild hypercapnia did not decrease lung oxygenation in sitting position, probably due to attenuation of the increase in dead-space ventilation ratio. Since hypercapnia maintained rSO2 without changes in oxygenation index and hemodynamic parameters, mild hypercapnia should be maintained during shoulder arthroscopy in sitting position under general anesthesia.
[Mh] Termos MeSH primário: Anestesia Geral/métodos
Artroscopia/métodos
Hipercapnia/metabolismo
Oxigênio/administração & dosagem
Oxigênio/sangue
Ombro/cirurgia
[Mh] Termos MeSH secundário: Idoso
Pressão Arterial
Gasometria
Feminino
Hemodinâmica/fisiologia
Seres Humanos
Hipercapnia/sangue
Hipoventilação/sangue
Hipoventilação/metabolismo
Masculino
Meia-Idade
Postura
Ventilação Pulmonar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE


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[PMID]:28189434
[Au] Autor:Ammar Y; Launois C; Perotin JM; Dury S; Servettaz A; Perdu D; Vallerand H; Nardi J; Boulagnon-Rombi C; Pluot M; Lebargy F; Deslee G
[Ad] Endereço:Service des maladies respiratoires, unité Inserm 903, hôpital Maison-Blanche, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France.
[Ti] Título:[Systemic lupus erythematosus presenting as severe alveolar hypoventilation and the shrinking lung syndrome].
[Ti] Título:Hypoventilation alvéolaire sévère révélant un shrinking lung syndrome lupique..
[So] Source:Rev Mal Respir;34(5):571-575, 2017 May.
[Is] ISSN:1776-2588
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: The shrinking lung syndrome (SLS) is a rare complication of systemic lupus erythematosus. CASE REPORT: A 69-year-old man presented with exertional dyspnoea, muscle weakness, and weight loss of 15kg in 6months. Pulmonary function tests revealed a restrictive lung disorder, with a dramatic decrease in maximal inspiratory pressure (17% of theoretical value), and alveolar hypoventilation (pH 7.43; PaCO 55mmHg). A thoracic CT-scan showed bilateral diaphragmatic elevation. The creatinine phophokinase level was increased at 280U/L. Progress was marked by a rapidly increasing respiratory acidosis (pH 7.24, PaCO 109mmHg) requiring invasive ventilation. Auto-immune studies revealed positive anti-nuclear antibodies (1/800) and positive anti-native DNA antibody at 45U/L. Treatment with systemic corticosteroids led to an initial improvement but it was not possible to discontinue mechanical ventilation. The outcome was fatal. Autopsy did not reveal any other cause and a diagnosis of the SLS associated with lupus was confirmed. CONCLUSION: The interesting features of this case report consist of: 1) the presentation of the SLS as an alveolar hypoventilation with a fatal outcome, 2) the presentation of systemic lupus as SLS.
[Mh] Termos MeSH primário: Hipoventilação/diagnóstico
Hipoventilação/etiologia
Pneumopatias/complicações
Pneumopatias/diagnóstico
Lúpus Eritematoso Sistêmico/complicações
Lúpus Eritematoso Sistêmico/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Diferencial
Seres Humanos
Masculino
Radiografia Torácica
Índice de Gravidade de Doença
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


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[PMID]:28159100
[Au] Autor:Augelli DM; Krieger AC
[Ad] Endereço:Department of Medicine, Center for Sleep Medicine, Weill Cornell Medical College, Cornell University, 425 East 61st Street, 5th Floor, New York, NY 10065, USA. Electronic address: dma9013@med.cornell.edu.
[Ti] Título:Social and Economic Impacts of Managing Sleep Hypoventilation Syndromes.
[So] Source:Sleep Med Clin;12(1):87-98, 2017 Mar.
[Is] ISSN:1556-4088
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypoventilation during sleep is often an early indicator of the development of respiratory failure. Alterations in ventilation are more pronounced during sleep and often present before the onset of daytime symptoms. This article discusses the most common sleep-related hypoventilatory disorders and recommended treatment approaches for obesity hypoventilation, chronic obstructive pulmonary disease, and neuromuscular disorders. Accurate diagnosis and appropriate treatment is of paramount importance because of the impact on individual health outcomes and overall cost of health care delivery. Appropriate treatment is successful at reducing hospitalizations and health care costs as well as improving quality of life and individual economic burden.
[Mh] Termos MeSH primário: Hipoventilação/economia
Hipoventilação/terapia
Síndromes da Apneia do Sono/economia
Síndromes da Apneia do Sono/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Hipoventilação/diagnóstico
Hipoventilação/epidemiologia
Doenças Neuromusculares/diagnóstico
Doenças Neuromusculares/economia
Doenças Neuromusculares/epidemiologia
Doenças Neuromusculares/terapia
Síndromes da Apneia do Sono/diagnóstico
Síndromes da Apneia do Sono/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28028188
[Au] Autor:Liu F; Kawakami M; Tamura K; Taki Y; Shimizu K; Otsuka T; Tsuji T; Miyata C; Tashiro S; Wada A; Mizuno K; Aoki Y; Liu M
[Ad] Endereço:Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:Feasibility of a Respiratory Movement Evaluation Tool to Quantify Thoracoabdominal Movement for Neuromuscular Diseases.
[So] Source:Respir Care;62(4):423-431, 2017 Apr.
[Is] ISSN:1943-3654
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An objective method to evaluate thoracoabdominal movement is needed in daily clinical practice to detect patients at risk of hypoventilation and to allow for timely interventions in neuromuscular diseases. The clinical feasibility, reliability, and validity of a newly developed method for quantifying respiratory movement using fiber grating sensors, called the Respiratory Movement Evaluation Tool (RMET), was evaluated. METHODS: The time needed to measure respiratory movement and the usability of the measurement were determined by 5 clinicians using the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST) 2.0 questionnaire. Thoracoabdominal movement was measured using RMET 3 times in 10 healthy subjects to evaluate intraclass correlation coefficients (ICC). The subjects were encouraged to breathe 10 times while voluntarily changing the amount of air during ventilation simultaneously with the RMET and a spirometer, and their correlations were evaluated to test validity using Pearson's product-moment correlation coefficients. The same measurements were also performed in 10 subjects with Duchenne muscular dystrophy. RESULTS: Real-time recordings of thoracoabdominal movements were obtained over a mean time of 374 ± 23.9 s. With QUEST 2.0, the median score of each item exceeded 3 (more or less satisfied). In healthy subjects, ICC(1,1) ranged from 0.82 to 0.99, and ICC(2,1) ranged from 0.83 to 0.97. Significant correlations were observed between the respiratory amplitudes measured with RMET, and the amount of air during ventilation was measured with a spirometer (r = 0.995, < .001). In subjects with Duchenne muscular dystrophy, ICC(1,1) ranged from 0.87 to 0.97, and ICC(2,1) ranged from 0.84 to 0.99. The respiratory amplitudes measured with RMET correlated significantly with the amount of air during ventilation with a spirometer (r = 0.957, < .001). CONCLUSIONS: We developed a novel method of quantifying respiratory movement called RMET that was feasible to use in daily clinical practice.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/instrumentação
Tecnologia de Fibra Óptica/instrumentação
Distrofia Muscular de Duchenne/fisiopatologia
Doenças Neuromusculares/fisiopatologia
Mecânica Respiratória/fisiologia
[Mh] Termos MeSH secundário: Abdome/fisiopatologia
Adulto
Técnicas Biossensoriais/métodos
Estudos de Casos e Controles
Estudos de Viabilidade
Feminino
Tecnologia de Fibra Óptica/métodos
Seres Humanos
Hipoventilação/diagnóstico
Hipoventilação/etiologia
Masculino
Movimento
Distrofia Muscular de Duchenne/complicações
Doenças Neuromusculares/complicações
Quebeque
Reprodutibilidade dos Testes
Respiração
Testes de Função Respiratória/instrumentação
Testes de Função Respiratória/métodos
Estatísticas não Paramétricas
Inquéritos e Questionários
Tórax/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.4187/respcare.04913



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