Base de dados : MEDLINE
Pesquisa : C08.674 [Categoria DeCS]
Referências encontradas : 8696 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 870 ir para página                         

  1 / 8696 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29446284
[Au] Autor:Kudaeva IV; Dyakovich OA; Beygel EA; Masnavieva LB; Naumova OV; Budarina LA
[Ti] Título:[Clinical, biochemical and allergological indices characterizing occupational diseases of the bronchial and pulmonary system in employees at aluminium production].
[So] Source:Gig Sanit;95(12):1142-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There are many harmful factors that possess a damaging impact on the body of employees at aluminum production. It leads to the development of bronchial asthma (BA), chronic nonobstructive bronchitis (CNB) and chronic obstructive pulmonary disease (COPD). The pathogenesis of these disorders, as well as sensitizing effect offluorine in the aluminum production is not fully understood. The purpose of this work was to study the characteristics of laboratory indices in patients with occupational diseases of the respiratory system. In workers of aluminum production with the diagnosis of occupational diseases of respiratory system (15 patients with a diagnosis of asthma, 30 CNB cases, 20 COPD patients) we evaluated the content of total protein, total cholesterol, high density lipoprotein cholesterol (HDLC), total calcium, phosphorus, ceruloplasmin, hematological indices and performed emigration of leukocytes braking test (TTEEL). Clinical and biochemical profile ofpersons with occupational asthma was characterized by a low level of total calcium and ceruloplasmin, a high concentration of phosphorus in the blood serum and inhibition of leukocyte emigration in the test with sodium fluoride. For aluminum production CNB workers characteristic active proatherogenic process was pronounced by a decrease in the HDLC level and an increase in atherogenic index; higher hematocrit value and concentration of erythrocytes, and more than 50% of cases of sensitization to the presence of sodium fluoride. COPD cases had occupational lower average concentration of hemoglobin in the erythrocyte, total protein in serum, as well as polymorphic variant response to sodium fluoride in the form of a depression and activation of leucocytes emigration.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Alumínio
Asma Ocupacional
Indústria Química
Doença Pulmonar Obstrutiva Crônica
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Alumínio/análise
Alumínio/toxicidade
Asma Ocupacional/sangue
Asma Ocupacional/diagnóstico
Asma Ocupacional/epidemiologia
Biomarcadores/análise
Indústria Química/métodos
Indústria Química/normas
Seres Humanos
Masculino
Meia-Idade
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Saúde do Trabalhador/estatística & dados numéricos
Doença Pulmonar Obstrutiva Crônica/sangue
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Doença Pulmonar Obstrutiva Crônica/etiologia
Hipersensibilidade Respiratória/sangue
Hipersensibilidade Respiratória/induzido quimicamente
Hipersensibilidade Respiratória/diagnóstico
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Biomarkers); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  2 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28459437
[Au] Autor:Toussaint M; Jackson DJ; Swieboda D; Guedán A; Tsourouktsoglou TD; Ching YM; Radermecker C; Makrinioti H; Aniscenko J; Bartlett NW; Edwards MR; Solari R; Farnir F; Papayannopoulos V; Bureau F; Marichal T; Johnston SL
[Ad] Endereço:Airway Disease Infection Section, National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
[Ti] Título:Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
[So] Source:Nat Med;23(6):681-691, 2017 06.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
[Mh] Termos MeSH primário: Asma/imunologia
Citocinas/imunologia
DNA/imunologia
Armadilhas Extracelulares/imunologia
Infecções por Picornaviridae/imunologia
Hipersensibilidade Respiratória/imunologia
Infecções Respiratórias/imunologia
Células Th2/imunologia
[Mh] Termos MeSH secundário: Adulto
Animais
Estudos de Casos e Controles
Dermatophagoides farinae/imunologia
Modelos Animais de Doenças
Feminino
Seres Humanos
Interferon gama/imunologia
Interleucina-13/imunologia
Interleucina-4/imunologia
Interleucina-5/imunologia
Masculino
Camundongos
Meia-Idade
Rhinovirus
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Interleukin-13); 0 (Interleukin-5); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4332


  3 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29329322
[Au] Autor:Eyring KR; Pedersen BS; Maclean KN; Stabler SP; Yang IV; Schwartz DA
[Ad] Endereço:Department of Medicine, School of Medicine, University of Colorado, Aurora, CO, United States of America.
[Ti] Título:Methylene-tetrahydrofolate reductase contributes to allergic airway disease.
[So] Source:PLoS One;13(1):e0190916, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Environmental exposures strongly influence the development and progression of asthma. We have previously demonstrated that mice exposed to a diet enriched with methyl donors during vulnerable periods of fetal development can enhance the heritable risk of allergic airway disease through epigenetic changes. There is conflicting evidence on the role of folate (one of the primary methyl donors) in modifying allergic airway disease. OBJECTIVES: We hypothesized that blocking folate metabolism through the loss of methylene-tetrahydrofolate reductase (Mthfr) activity would reduce the allergic airway disease phenotype through epigenetic mechanisms. METHODS: Allergic airway disease was induced in C57BL/6 and C57BL/6Mthfr-/- mice through house dust mite (HDM) exposure. Airway inflammation and airway hyperresponsiveness (AHR) were measured between the two groups. Gene expression and methylation profiles were generated for whole lung tissue. Disease and molecular outcomes were evaluated in C57BL/6 and C57BL/6Mthfr-/- mice supplemented with betaine. MEASUREMENTS AND MAIN RESULTS: Loss of Mthfr alters single carbon metabolite levels in the lung and serum including elevated homocysteine and cystathionine and reduced methionine. HDM-treated C57BL/6Mthfr-/- mice demonstrated significantly less airway hyperreactivity (AHR) compared to HDM-treated C57BL/6 mice. Furthermore, HDM-treated C57BL/6Mthfr-/- mice compared to HDM-treated C57BL/6 mice have reduced whole lung lavage (WLL) cellularity, eosinophilia, and Il-4/Il-5 cytokine concentrations. Betaine supplementation reversed parts of the HDM-induced allergic airway disease that are modified by Mthfr loss. 737 genes are differentially expressed and 146 regions are differentially methylated in lung tissue from HDM-treated C57BL/6Mthfr-/- mice and HDM-treated C57BL/6 mice. Additionally, analysis of methylation/expression relationships identified 503 significant correlations. CONCLUSION: Collectively, these findings indicate that the loss of folate as a methyl donor is a modifier of allergic airway disease, and that epigenetic and expression changes correlate with this modification. Further investigation into the mechanisms that drive this observation is warranted.
[Mh] Termos MeSH primário: Metilenotetra-Hidrofolato Redutase (NADPH2)/fisiologia
Hipersensibilidade Respiratória/enzimologia
[Mh] Termos MeSH secundário: Animais
Betaína/administração & dosagem
Metilação de DNA
Expressão Gênica
Metilenotetra-Hidrofolato Redutase (NADPH2)/genética
Camundongos
Camundongos Endogâmicos C57BL
Locos de Características Quantitativas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
3SCV180C9W (Betaine); EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190916


  4 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28742120
[Au] Autor:Skappak C; Ilarraza R; Wu YQ; Drake MG; Adamko DJ
[Ad] Endereço:Division of Emergency Medicine, McMaster University, Hamilton, Ontario, Canada.
[Ti] Título:Virus-induced asthma attack: The importance of allergic inflammation in response to viral antigen in an animal model of asthma.
[So] Source:PLoS One;12(7):e0181425, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Asthma exacerbation can be a life-threatening condition, and is most often triggered by common respiratory viruses. Poor asthma control and worsening of respiratory function is associated with increased airway inflammation, including eosinophilia. Prevention of asthma exacerbation relies on treatment with corticosteroids, which preferentially inhibit allergic inflammation like eosinophils. Human studies demonstrate that inactivated virus can trigger eosinophil activation in vitro through antigen presentation and memory CD4+ lymphocytes. We hypothesized that animals with immunologic memory to a respiratory virus would also develop airway hyperresponsiveness in response to a UV-inactivated form of the virus if they have pre-existing allergic airway inflammation. Guinea pigs were ovalbumin-sensitized, infected with live parainfluenza virus (PIV), aerosol-challenged with ovalbumin, and then re-inoculated 60 days later with live or UV-inactivated PIV. Some animals were either treated with dexamethasone prior to the second viral exposure. Lymphocytes were isolated from parabronchial lymph nodes to confirm immunologic memory to the virus. Airway reactivity was measured and inflammation was assessed using bronchoalveolar lavage and lung histology. The induction of viral immunologic memory was confirmed in infected animals. Allergen sensitized and challenged animals developed airway hyperreactivity with eosinophilic airway inflammation when re-exposed to UV-inactivated PIV, while non-sensitized animals did not. Airway hyperreactivity in the sensitized animals was inhibited by pre-treatment with dexamethasone. We suggest that the response of allergic inflammation to virus antigen is a significant factor causing asthma exacerbation. We propose that this is one mechanism explaining how corticosteroids prevent virus-induced asthma attack.
[Mh] Termos MeSH primário: Asma/virologia
Vírus da Parainfluenza 1 Humana/imunologia
Hipersensibilidade Respiratória/virologia
Infecções por Respirovirus/complicações
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Asma/tratamento farmacológico
Asma/imunologia
Dexametasona/uso terapêutico
Modelos Animais de Doenças
Feminino
Cobaias
Seres Humanos
Memória Imunológica/efeitos dos fármacos
Inflamação/tratamento farmacológico
Inflamação/imunologia
Inflamação/virologia
Linfócitos/imunologia
Linfócitos/virologia
Hipersensibilidade Respiratória/tratamento farmacológico
Hipersensibilidade Respiratória/imunologia
Infecções por Respirovirus/tratamento farmacológico
Infecções por Respirovirus/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181425


  5 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28966308
[Au] Autor:Wu D; Jiang Z; Gong B; Dou Y; Song M; Song X; Tian Y
[Ad] Endereço:Department of Echocardiography, The Affiliated Hospital of Qingdao University, Qingdao.
[Ti] Título:Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy.
[So] Source:Int Heart J;58(5):769-777, 2017 Oct 21.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In this study, we investigated the protection effect of Vitamin E (Vit E) on formaldehyde (FA) exposure during pregnancy induced apoptosis of cardiomyocytes, and used an HL-1 cell line to confirmed the findings in vivo.Pregnant mice received different doses of FA (0.5 mg/kg, 1.0 mg/kg, 1.5 mg/kg, 0.1 µg Vit E, or 1.5 mg/kg + 0.1 µg Vit E). TUNEL staining was used to reveal the apoptosis in cardiomyocytes, and SOD, MDA, GSH, Livin, and Caspase-3 in cardiomyocytes were detected by ELISA, RT-PCR, and Western blot. For in vitro study, HL-1 cells were treated with vehicle, 5 µmol/L FA, 25 µmol/L FA, 50 µmol/L FA, 10 mg/L Vit. E, and 50 µmol/L FA+ 10 mg/L Vit E, respectively. CCK-8 assay and flow cytometry were used to evaluate cell vitality and apoptosis. A high dose of FA exposure led to cytotoxicity in both pregnant mice and offspring, as TUNEL staining revealed a significant apoptosis of cardiomyocytes, and the alternation in SOD, GSH, MDA, Livin, and Caspase-3 was found in cardiomyocytes. 0.1 µg Vit. E could reverse high doses of FA exposure induced apoptosis of cardiomyocytes in both pregnant mice and offspring. The in vitro study revealed that FA exposure induced a decrease of cell viability and increased cell apoptosis, as well as oxidative stress in HL-1 cells with alternation in SOD, GSH, MDA, Livin, and Caspase-3.This study revealed a high dose of FA induced oxidative stress and apoptosis of cardiomyocytes in both pregnant mice and offspring, and Vit E supplement during pregnancy reversed the systemic and myocardial toxicity of FA.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Formaldeído/efeitos adversos
Miócitos Cardíacos/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Prenhez
Hipersensibilidade Respiratória/tratamento farmacológico
Vitamina E/farmacologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Antioxidantes/farmacologia
Western Blotting
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Feminino
Formaldeído/metabolismo
Formaldeído/toxicidade
Marcação In Situ das Extremidades Cortadas
Camundongos
Miócitos Cardíacos/efeitos dos fármacos
Miócitos Cardíacos/patologia
Gravidez
Complicações na Gravidez/induzido quimicamente
Complicações na Gravidez/metabolismo
Complicações na Gravidez/patologia
Hipersensibilidade Respiratória/metabolismo
Hipersensibilidade Respiratória/patologia
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 1406-18-4 (Vitamin E); 1HG84L3525 (Formaldehyde); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-279


  6 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28772166
[Au] Autor:Ye Z; Ren L; Tang Z; Deng Y; Xie X; Fu Z; Luo Z; Xu F; Zang N; Liu E
[Ad] Endereço:Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China; Department of Respiratory Medicine, Chil
[Ti] Título:Pulmonary C-fiber degeneration downregulates IFN-γ receptor 1 via IFN-α induction to attenuate RSV-induced airway hyperresponsiveness.
[So] Source:Virology;510:262-272, 2017 Oct.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory syncytial virus (RSV) is a leading cause of respiratory infection in infants. Unfortunately, no effective vaccine or treatment against RSV is currently available. Pulmonary C-fibers (PCFs) are critical for regulating pulmonary inflammation and airway hyperresponsiveness (AHR). We previously reported that IFN-γ partially mediated RSV-induced airway disorders. In this study, we found that PCF degeneration alleviated RSV-induced airway inflammation, especially AHR by downregulating IFN-γ receptor 1 (IFNGR1), but had no effect on IFN-γ induction. In contrast, PCF degeneration actually increased IFN-α/ß levels, as were the levels of STAT1 and phosphorylated STAT1 (pSTAT1). Exogenous IFN-α treatment induced STAT1 activation and downregulated IFNGR1 expression. These results suggest that PCFs affect IFNGR1 expression by inducing IFN-α to regulate IFN-γ-mediated airway inflammation and AHR. Thus, targeting PCFs activation may help control RSV-induced airway disorders, especially AHR, even with the presence of inflammation.
[Mh] Termos MeSH primário: Regulação para Baixo
Interações Hospedeiro-Patógeno
Interferon-alfa/metabolismo
Fibras Nervosas Amielínicas/metabolismo
Receptores de Interferon/biossíntese
Hipersensibilidade Respiratória
Vírus Sinciciais Respiratórios/imunologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Camundongos Endogâmicos BALB C
Infecções por Vírus Respiratório Sincicial/patologia
Infecções por Vírus Respiratório Sincicial/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon-alpha); 0 (Receptors, Interferon); 0 (interferon gamma receptor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


  7 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28759052
[Au] Autor:Zhang D; Chia C; Jiao X; Jin W; Kasagi S; Wu R; Konkel JE; Nakatsukasa H; Zanvit P; Goldberg N; Chen Q; Sun L; Chen ZJ; Chen W
[Ad] Endereço:Mucosal Immunology Section, NIDCR, US National Institutes of Health, Bethesda, Maryland, USA.
[Ti] Título:D-mannose induces regulatory T cells and suppresses immunopathology.
[So] Source:Nat Med;23(9):1036-1045, 2017 Sep.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:D-mannose, a C-2 epimer of glucose, exists naturally in many plants and fruits, and is found in human blood at concentrations less than one-fiftieth of that of glucose. However, although the roles of glucose in T cell metabolism, diabetes and obesity are well characterized, the function of D-mannose in T cell immune responses remains unknown. Here we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation, and increased the proportion of Foxp3 regulatory T cells (T cells) in mice. In vitro, D-mannose stimulated T cell differentiation in human and mouse cells by promoting TGF-ß activation, which in turn was mediated by upregulation of integrin α ß and reactive oxygen species generated by increased fatty acid oxidation. This previously unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopathology.
[Mh] Termos MeSH primário: Colite/imunologia
Diabetes Mellitus Tipo 1/imunologia
Pneumopatias/imunologia
Pulmão/efeitos dos fármacos
Manose/farmacologia
Pâncreas/efeitos dos fármacos
Hipersensibilidade Respiratória/imunologia
Linfócitos T Reguladores/efeitos dos fármacos
Fator de Crescimento Transformador beta/efeitos dos fármacos
[Mh] Termos MeSH secundário: Transferência Adotiva
Animais
Colo/efeitos dos fármacos
Suplementos Nutricionais
Modelos Animais de Doenças
Ácidos Graxos/metabolismo
Citometria de Fluxo
Fatores de Transcrição Forkhead/metabolismo
Seres Humanos
Técnicas In Vitro
Inflamação
Integrinas/efeitos dos fármacos
Integrinas/imunologia
Metabolismo dos Lipídeos/efeitos dos fármacos
Pulmão/imunologia
Pneumopatias/induzido quimicamente
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos NOD
Ovalbumina/efeitos adversos
Oxirredução/efeitos dos fármacos
Pâncreas/imunologia
Espécies Reativas de Oxigênio/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Hipersensibilidade Respiratória/induzido quimicamente
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Baço/efeitos dos fármacos
Baço/imunologia
Linfócitos T Reguladores/imunologia
Linfócitos T Reguladores/metabolismo
Fator de Crescimento Transformador beta/imunologia
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Forkhead Transcription Factors); 0 (Foxp3 protein, mouse); 0 (Integrins); 0 (Reactive Oxygen Species); 0 (Transforming Growth Factor beta); 0 (integrin alphavbeta8); 9006-59-1 (Ovalbumin); PHA4727WTP (Mannose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4375


  8 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28758900
[Au] Autor:Whitehead GS; Thomas SY; Shalaby KH; Nakano K; Moran TP; Ward JM; Flake GP; Nakano H; Cook DN
[Ad] Endereço:Immunity, Inflammation and Disease Laboratory.
[Ti] Título:TNF is required for TLR ligand-mediated but not protease-mediated allergic airway inflammation.
[So] Source:J Clin Invest;127(9):3313-3326, 2017 Sep 01.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Asthma is associated with exposure to a wide variety of allergens and adjuvants. The extent to which overlap exists between the cellular and molecular mechanisms triggered by these various agents is poorly understood, but it might explain the differential responsiveness of patients to specific therapies. In particular, it is unclear why some, but not all, patients benefit from blockade of TNF. Here, we characterized signaling pathways triggered by distinct types of adjuvants during allergic sensitization. Mice sensitized to an innocuous protein using TLR ligands or house dust extracts as adjuvants developed mixed eosinophilic and neutrophilic airway inflammation and airway hyperresponsiveness (AHR) following allergen challenge, whereas mice sensitized using proteases as adjuvants developed predominantly eosinophilic inflammation and AHR. TLR ligands, but not proteases, induced TNF during allergic sensitization. TNF signaled through airway epithelial cells to reprogram them and promote Th2, but not Th17, development in lymph nodes. TNF was also required during the allergen challenge phase for neutrophilic and eosinophilic inflammation. In contrast, TNF was dispensable for allergic airway disease in a protease-mediated model of asthma. These findings might help to explain why TNF blockade improves lung function in only some patients with asthma.
[Mh] Termos MeSH primário: Hipersensibilidade/metabolismo
Inflamação/fisiopatologia
Hipersensibilidade Respiratória/metabolismo
Receptores Toll-Like/metabolismo
Fator de Necrose Tumoral alfa/fisiologia
[Mh] Termos MeSH secundário: Alérgenos
Animais
Asma/metabolismo
Asma/fisiopatologia
Hiper-Reatividade Brônquica/fisiopatologia
Diferenciação Celular
Citocinas/metabolismo
Modelos Animais de Doenças
Eosinófilos/citologia
Hipersensibilidade/fisiopatologia
Interleucina-17/metabolismo
Ligantes
Pulmão/fisiopatologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Neutrófilos/citologia
Ovalbumina/metabolismo
Hipersensibilidade Respiratória/fisiopatologia
Transdução de Sinais
Células Th17/citologia
Células Th2/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Cytokines); 0 (Interleukin-17); 0 (Ligands); 0 (Toll-Like Receptors); 0 (Tumor Necrosis Factor-alpha); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE


  9 / 8696 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28757230
[Au] Autor:Määttä AM; Kotaniemi-Syrjänen A; Malmström K; Malmberg LP; Sundvall J; Pelkonen AS; Mäkelä MJ
[Ad] Endereço:Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. Electronic address: anette.m.maatta@helsinki.fi.
[Ti] Título:Vitamin D, high-sensitivity C-reactive protein, and airway hyperresponsiveness in infants with recurrent respiratory symptoms.
[So] Source:Ann Allergy Asthma Immunol;119(3):227-231, 2017 Sep.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Vitamin D insufficiency might be associated with biased T-cell responses resulting in inflammatory conditions such as atopy and asthma. Little is known about the role of vitamin D in low-grade systemic inflammation and airway hyperresponsiveness (AHR) in young children. OBJECTIVE: To evaluate whether vitamin D insufficiency and increased serum high-sensitivity C-reactive protein (hs-CRP) are linked to AHR in symptomatic infants. METHODS: Seventy-nine infants with recurrent or persistent lower respiratory tract symptoms underwent comprehensive lung function testing and a bronchial methacholine challenge test. In addition, skin prick tests were performed and serum 25-hydroxyvitamin D (S-25-OHD), hs-CRP, total immunoglobulin E, and blood eosinophil levels were determined. RESULTS: S-25-OHD was lowest in infants with blood eosinophilia and AHR (n = 10) compared with those with eosinophilia only (n = 6) or AHR only (n = 50) or those with neither (n = 13; P = .035). Moreover, vitamin D insufficiency (S-25-OHD <50 nmol/L) was most common in infants with blood eosinophilia and AHR (P = .041). Serum hs-CRP was lower in infants with recurrent physician-diagnosed wheezing (P = .048) and in those with blood eosinophilia (P = .015) than in infants without these characteristics and was not associated with S-25-OHD or AHR. S-25-OHD levels were significantly lower (median 54 nmol/L) during the autumn-winter season than in the spring-summer season (median 63 nmol/L; P = .026). CONCLUSION: Vitamin D insufficiency could underlie eosinophilia and AHR in infants with troublesome lung symptoms, whereas hs-CRP-mediated low-grade systemic inflammation is rare in early childhood wheezing.
[Mh] Termos MeSH primário: Proteína C-Reativa/análise
Eosinofilia/sangue
Hipersensibilidade Respiratória/sangue
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Pré-Escolar
Eosinofilia/fisiopatologia
Feminino
Seres Humanos
Lactente
Contagem de Leucócitos
Masculino
Hipersensibilidade Respiratória/fisiopatologia
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE


  10 / 8696 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28731412
[Au] Autor:Shimoda T; Obase Y; Nagasaka Y; Nakano H; Kishikawa R; Iwanaga T
[Ad] Endereço:Clinical Research Center, Fukuoka National Hospital, Fukuoka, Japan.
[Ti] Título:Lung Sound Analysis Is Useful for Monitoring Therapy in Patients With Bronchial Asthma.
[So] Source:J Investig Allergol Clin Immunol;27(4):246-251, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Lung sound analysis (LSA) has been reported to be useful for predicting airway obstruction and inflammation in patients with bronchial asthma. Objectives: We examined whether the exhalation-to-inhalation sound pressure ratio in the middle frequency range (200-400 Hz) (E/I MF) is useful for monitoring therapy in patients with asthma. METHODS: The study population comprised 84 patients with mild to moderate asthma whose LSA data were available before and after 1 year of daily treatment with (budesonide 800 µg). We analyzed whether the E/I MF before and after treatment was associated with the fractional exhaled nitric oxide (FeNO) level, sputum eosinophil percentage, respiratory function, and airway hyperresponsiveness. RESULTS: Prior to treatment with budesonide, the E/I MF was significantly correlated with respiratory function, airway hyperresponsiveness, FeNO, and sputum eosinophil percentage. The cutoff values for the E/I MF to detect the abnormalities of respiratory function, FeNO, and sputum eosinophil percentage were 0.367, 0.358, and 0.363, respectively. With respect to the reference value, the E/I MF improved significantly in patients whose respiratory function and FeNO benefited from therapy with budesonide compared with patients whose respiratory function did not benefit from budesonide (odds ratios of 6.39 and 4.78, respectively). According to the multivariate analysis, patients whose E/I MF did not improve had a longer history of smoking (P=.038), poorer posttreatment respiratory function (P=.028), and higher posttreatment FeNO (P=.0095). CONCLUSIONS: Similar to respiratory function and FeNO, E/I MF based on LSA is a useful indicator for monitoring the efficacy of therapy in asthmatic patients.
[Mh] Termos MeSH primário: Asma/tratamento farmacológico
Budesonida/uso terapêutico
Glucocorticoides/uso terapêutico
Hipersensibilidade Respiratória/tratamento farmacológico
Sons Respiratórios/fisiopatologia
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Adulto
Idoso
Asma/imunologia
Asma/metabolismo
Asma/fisiopatologia
Testes Respiratórios
Eosinófilos/citologia
Feminino
Volume Expiratório Forçado
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Óxido Nítrico/metabolismo
Testes de Função Respiratória
Hipersensibilidade Respiratória/imunologia
Hipersensibilidade Respiratória/metabolismo
Hipersensibilidade Respiratória/fisiopatologia
Processamento de Sinais Assistido por Computador
Fumar
Escarro/citologia
Capacidade Vital
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 31C4KY9ESH (Nitric Oxide); 51333-22-3 (Budesonide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0132



página 1 de 870 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde