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  1 / 229 MEDLINE  
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[PMID]:29206855
[Au] Autor:Delabouglise A; James A; Valarcher JF; Hagglünd S; Raboisson D; Rushton J
[Ad] Endereço:Veterinary Epidemiology, Economics and Public Health Group, Department of Production and Population Health, Royal Veterinary College, University of London, Hawkshead Lane, Hatfield, Hertfordshire, United Kingdom.
[Ti] Título:Linking disease epidemiology and livestock productivity: The case of bovine respiratory disease in France.
[So] Source:PLoS One;12(12):e0189090, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Concerns are growing over the impact of livestock farming on environment and public health. The livestock industry is faced with the double constraint of limiting its use of natural resources and antimicrobials while ensuring its economic sustainability. In this context, reliable methods are needed to evaluate the effect of the prevention of endemic animal diseases on the productivity of livestock production systems. In this study, an epidemiological and productivity model was used to link changes in Bovine Respiratory Disease (BRD) incidence with the productivity of the beef and dairy cattle sectors in France. Cattle production parameters significantly affected by BRD were selected through literature review. Previous field study results and national cattle performance estimates were used to infer growth performances, mortality rates and carcass quality in the cattle affected and not affected by BRD. A steady-state deterministic herd production model was used to predict the productivity of the dairy and beef sector and their defined compartments (breeding-fattening, feedlot young bulls, and feedlot veal) in case of BRD incidence reduction by 20%, 50% or 100%. Results suggested that BRD should be controlled at a priority in beef breeding farms as eradication of BRD in beef calves would increase the whole beef sector's productivity by 4.7-5.5% while eradication in other production stages would result in lower productivity gain in their respective sectors. However, the analysis performed at compartment level showed that, in both the beef and dairy sector, young bull and veal feedlot enterprises derive more economic benefits from BRD eradication for their own compartment (increase in productivity of 8.7-12.8% for beef young bulls) than the breeding farms (increase in productivity of 5.1-6% for beef calves), which may limit the investments in BRD control.
[Mh] Termos MeSH primário: Complexo Respiratório Bovino/epidemiologia
[Mh] Termos MeSH secundário: Criação de Animais Domésticos
Animais
Cruzamento
Bovinos
Feminino
França/epidemiologia
Incidência
Masculino
Modelos Teóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189090


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[PMID]:28462738
[Au] Autor:Volkova VV; Cazer CL; Gröhn YT
[Ad] Endereço:Department of Diagnostic Medicine/Pathobiology,Institute of Computational Comparative Medicine, College of Veterinary Medicine, Kansas State University,Mosier Hall, KS 66506,USA.
[Ti] Título:Models of antimicrobial pressure on intestinal bacteria of the treated host populations.
[So] Source:Epidemiol Infect;145(10):2081-2094, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antimicrobial drugs are used to treat pathogenic bacterial infections in animals and humans. The by-stander enteric bacteria of the treated host's intestine can become exposed to the drug or its metabolites reaching the intestine in antimicrobially active form. We consider which processes and variables need to be accounted for to project the antimicrobial concentrations in the host's intestine. Those include: the drug's fraction (inclusive of any active metabolites) excreted in bile; the drug's fractions and intestinal segments of excretion via other mechanisms; the rates and intestinal segments of the drug's absorption and re-absorption; the rates and intestinal segments of the drug's abiotic and biotic degradation in the intestine; the digesta passage time through the intestinal segments; the rates, mechanisms, and reversibility of the drug's sorption to the digesta and enteric microbiome; and the volume of luminal contents in the intestinal segments. For certain antimicrobials, the antimicrobial activity can further depend on the aeration and chemical conditions in the intestine. Model forms that incorporate the inter-individual variation in those relevant variables can support projections of the intestinal antimicrobial concentrations in populations of treated host, such as food animals. To illustrate the proposed modeling framework, we develop two examples of treatments of bovine respiratory disease in beef steers by oral chlortetracycline and injectable third-generation cephalosporin ceftiofur. The host's diet influences the digesta passage time, volume, and digesta and microbiome composition, and may influence the antimicrobial loss due to degradation and sorption in the intestine. We consider two diet compositions in the illustrative simulations. The examples highlight the extent of current ignorance and need for empirical data on the variables influencing the selective pressures imposed by antimicrobial treatments on the host's intestinal bacteria.
[Mh] Termos MeSH primário: Complexo Respiratório Bovino/tratamento farmacológico
Cefalosporinas/administração & dosagem
Cefalosporinas/farmacologia
Clortetraciclina/administração & dosagem
Clortetraciclina/farmacologia
Microbioma Gastrointestinal/efeitos dos fármacos
Modelos Biológicos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Infecciosos/administração & dosagem
Anti-Infecciosos/farmacologia
Complexo Respiratório Bovino/microbiologia
Injeções/veterinária
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Cephalosporins); 83JL932I1C (ceftiofur); WCK1KIQ23Q (Chlortetracycline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1017/S095026881700084X


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[PMID]:28827826
[Au] Autor:Dassanayake RP; Falkenberg SM; Briggs RE; Tatum FM; Sacco RE
[Ad] Endereço:Ruminant Diseases and Immunology Research Unit, National Animal Disease Center, United States Department of Agriculture, Agricultural Research Service, Ames, Iowa, United States of America.
[Ti] Título:Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni.
[So] Source:PLoS One;12(8):e0183610, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bovine NK-lysins, which are functionally and structurally similar to human granulysin and porcine NK-lysin, are predominantly found in the granules of cytotoxic T-lymphocytes and NK-cells. Although antimicrobial activity of bovine NK-lysin has been assessed for several bacterial pathogens, not all the important bacterial pathogens that are involved in the bovine respiratory disease complex have been studied. Therefore the objective of the present study was to evaluate the antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. Four, 30-mer peptides corresponding to the functional region of NK-lysin helices 2 and 3 were synthesized and assessed for antibacterial activity on four bovine pneumonic H. somni isolates. Although there were some differences in the efficiency of bactericidal activity among the NK-lysin peptides at lower concentrations (2-5 µM), all four peptides effectively killed most H. somni isolates at higher concentrations (10-30 µM) as determined by a bacterial killing assay. Confocal microscopic and flow cytometric analysis of Live/Dead Baclight stained H. somni (which were preincubated with NK-lysin peptides) were consistent with the killing assay findings and suggest NK-lysin peptides are bactericidal for H. somni. Among the four peptides, NK2A-derived peptide consistently showed the highest antimicrobial activity against all four H. somni isolates. Electron microscopic examination of H. somni following incubation with NK-lysin revealed extensive cell membrane damage, protrusions of outer membranes, and cytoplasmic content leakage. Taken together, the findings from this study clearly demonstrate the antimicrobial activity of all four bovine NK-lysin-derived peptides against bovine H. somni isolates.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Complexo Respiratório Bovino/prevenção & controle
Pasteurellaceae/efeitos dos fármacos
Peptídeos/farmacologia
Proteolipídeos/farmacologia
Sistema Respiratório/microbiologia
[Mh] Termos MeSH secundário: Animais
Complexo Respiratório Bovino/microbiologia
Bovinos
Microscopia Eletrônica de Transmissão
Proteolipídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (NK-lysin); 0 (Peptides); 0 (Proteolipids)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183610


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[PMID]:28802127
[Au] Autor:Ilg T
[Ad] Endereço:Bayer Animal Health GmbH, Alfred-Nobel-Strasse 50, 40789 Monheim, Germany. Electronic address: thomas.ilg@bayer.com.
[Ti] Título:Investigations on the molecular mode of action of the novel immunostimulator ZelNate: Activation of the cGAS-STING pathway in mammalian cells.
[So] Source:Mol Immunol;90:182-189, 2017 Oct.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bovine respiratory disease (BRD) is usually prevented or treated with vaccines and/or antibiotics. The use of antibiotics is, however, of concern due to the potential promotion of microbial resistance and the occurrence of residues. Recently an alternative aid in the treatment of BRD, the cationic lipid/bacterial plasmid DNA liposome-based immunomodulator ZelNate, has entered the veterinary market. In the present study, we provide data on the molecular mode of action of ZelNate. Despite the presence of numerous non-methylated CpG motifs in its plasmid DNA, ZelNate proved to be inactive on human and mouse toll-like receptor 9 (TLR9) in cell culture, in both recombinant and natural cellular receptor settings. However, in the human monocyte cell line THP1 and in the mouse melanoma cell line B16, ZelNate activates strongly the stimulator of interferon genes (STING) pathway, which is known to lead predominantly to interferon response factor 3 (IRF3) activation. Further analysis in THP1 cells suggests that the ZelNate plasmid DNA activates STING via interaction with cyclic guanylate adenylate synthase (cGAS), but not via interferon induced gene 16 (IFI16). Our in vitro observations suggest that ZelNate may act predominantly via the cGAS/STING/IRF3 pathway.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/farmacologia
Complexo Respiratório Bovino/tratamento farmacológico
DNA/farmacologia
Fator Regulador 3 de Interferon/metabolismo
Proteínas de Membrana/metabolismo
Nucleotidiltransferases/metabolismo
[Mh] Termos MeSH secundário: Animais
Bovinos
Linhagem Celular
Seres Humanos
Lipossomos/farmacologia
Camundongos
Monócitos
Proteínas Nucleares/metabolismo
Fosfoproteínas/metabolismo
Receptor Toll-Like 9/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (IRF3 protein, human); 0 (Interferon Regulatory Factor-3); 0 (Liposomes); 0 (MPYS protein, human); 0 (Membrane Proteins); 0 (Nuclear Proteins); 0 (Phosphoproteins); 0 (TLR9 protein, human); 0 (Tlr9 protein, mouse); 0 (Toll-Like Receptor 9); 0 (ZelNate); 148998-64-5 (IFI16 protein, human); 9007-49-2 (DNA); EC 2.7.7.- (MB21D1 protein, human); EC 2.7.7.- (Nucleotidyltransferases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


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[PMID]:28425146
[Au] Autor:Van Driessche L; Valgaeren BR; Gille L; Boyen F; Ducatelle R; Haesebrouck F; Deprez P; Pardon B
[Ad] Endereço:Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
[Ti] Título:A Deep Nasopharyngeal Swab Versus Nonendoscopic Bronchoalveolar Lavage for Isolation of Bacterial Pathogens from Preweaned Calves With Respiratory Disease.
[So] Source:J Vet Intern Med;31(3):946-953, 2017 May.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nonendoscopic bronchoalveolar lavage (BAL) is a practical alternative for a deep nasopharyngeal swab (DNS) to sample the airways of a large number of calves in a short period of time. The extent of commensal overgrowth and agreement of BAL with DNS culture results in preweaned calves are unknown. OBJECTIVES: To compare commensal overgrowth and bacterial culture results between DNS and BAL samples. ANIMALS: A total of 183 preweaned calves (144 with bovine respiratory disease and 39 healthy animals). METHODS: Cross-sectional study. Deep nasopharyngeal swab and BAL samples were taken from each calf and cultured to detect Pasteurellaceae and Mycoplasma bovis. Agreement and associations between culture results of DNS and BAL samples were determined by kappa statistics and logistic regression. RESULTS: Bronchoalveolar lavage samples were less often polymicrobial, more frequently negative and yielded more pure cultures compared to DNS, leading to a clinically interpretable culture result in 79.2% of the cases compared to only in 31.2% of the DNS samples. Isolation rates were lower in healthy animals, but not different between DNS and BAL samples. Only Histophilus somni was more likely to be isolated from BAL samples. In clinical cases, a polymicrobial DNS culture result did not increase the probability of a polymicrobial BAL result by ≥30%, nor did it influence the probability of a negative culture. A significant herd effect was noted for all observed relationships. CONCLUSIONS AND CLINICAL RELEVANCE: Nonendoscopic BAL samples are far less overgrown by bacteria compared to DNS samples under the conditions of this study, facilitating clinical interpretation and resulting in a higher return on investment in bacteriologic culturing.
[Mh] Termos MeSH primário: Complexo Respiratório Bovino/microbiologia
Líquido da Lavagem Broncoalveolar/microbiologia
Mycoplasma bovis/isolamento & purificação
Nasofaringe/microbiologia
Pasteurellaceae/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Complexo Respiratório Bovino/diagnóstico
Lavagem Broncoalveolar/veterinária
Bovinos
Estudos Transversais
Infecções por Mycoplasma/diagnóstico
Infecções por Mycoplasma/veterinária
Infecções por Pasteurellaceae/diagnóstico
Infecções por Pasteurellaceae/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.14668


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[PMID]:28390431
[Au] Autor:Cornelissen JB; de Bree FM; van der Wal FJ; Kooi EA; Koene MG; Bossers A; Smid B; Antonis AF; Wisselink HJ
[Ad] Endereço:Department of Infection Biology, Central Veterinary Institute of Wageningen UR, P.O. Box 65, 8200, AB, Lelystad, The Netherlands. jan.cornelissen@wur.nl.
[Ti] Título:Mycoplasma detection by triplex real-time PCR in bronchoalveolar lavage fluid from bovine respiratory disease complex cases.
[So] Source:BMC Vet Res;13(1):97, 2017 Apr 08.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study we evaluated the RespoCheck Mycoplasma triplex real-time PCR for the detection in bronchoalveolar lavage fluid (BALF) of Mycoplasma (M.) dispar, M. bovis and M. bovirhinis, all three associated with bovine respiratory disease (BRD). Primers and probes of the RespoCheck Mycoplasma triplex real-time PCR are based on the V3/V4 region of the 16S rRNA gene of the three Mycoplasma species. RESULTS: The analytical sensitivity of the RespoCheck triplex real-time PCR was, as determined by spiking experiments of the Mycoplasma strains in Phosphate Buffered Saline, 300 colony forming units (cfu)/mL for M. dispar, and 30 cfu/mL for M. bovis or M. bovirhinis. The analytical sensitivity of the RespoCheck Mycoplasma triplex real-time PCRwas, as determined on purified DNA, 10 fg DNA per assay for M. dispar and 100 fg fo rM. bovis and M. bovirhinis. The analytical specificity of the RespoCheck Mycoplasma triplex real-time PCR was, as determined by testing Mycoplasmas strains (n = 17) and other bacterial strains (n = 107), 100, 98.2 and 99.1% for M. bovis, M. dispar and M. bovirhinis respectively. The RespoCheck Mycoplasma triplex real-time PCR was compared with the PCR/DGGE analysis for M. bovis, M. dispar and M. bovirhinis respectively by testing 44 BALF samples from calves. CONCLUSION: In conclusion, the RespoCheck PCR assay can be a valuable tool for timely and accurate detection of three Mycoplasma species associated with in bovine respiratory disease.
[Mh] Termos MeSH primário: Complexo Respiratório Bovino/diagnóstico
Infecções por Mycoplasma/veterinária
Mycoplasma/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Complexo Respiratório Bovino/microbiologia
Líquido da Lavagem Broncoalveolar/microbiologia
Bovinos
Mycoplasma/genética
Infecções por Mycoplasma/diagnóstico
RNA Ribossômico 16S/genética
Reação em Cadeia da Polimerase em Tempo Real/veterinária
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1023-6


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[PMID]:28380607
[Au] Autor:Abell KM; Theurer ME; Larson RL; White BJ; Apley M
[Ti] Título:A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle.
[So] Source:J Anim Sci;95(2):626-635, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this project was to evaluate the effects of antimicrobials approved for parenteral metaphylactic use in feeder and stocker calves on morbidity and mortality for bovine respiratory disease with the use of a mixed treatment comparison meta-analysis. An initial literature review was conducted in April 2016 through Pubmed, Agricola, and CAB (Commonwealth Agricultural Bureau) for randomized controlled trials for metaphylaxis antimicrobial administered parentally to incoming feedlot or stocker calves within 48 h of arrival. The final list of publications included 29 studies, with a total of 37 trials. There were 8 different metaphylactic antimicrobials. Final event outcomes were categorized into bovine respiratory disease (BRD) morbidity cumulative incidence d 1 to ≤ 60 of the feeding period, BRD morbidity cumulative incidence d 1 to closeout of the feeding period, BRD mortality cumulative incidence d 1 to closeout of the feeding period, and BRD retreatment cumulative incidence morbidity d 1 to closeout of the feeding period. Network meta-analysis combined direct and indirect evidence for all the event outcomes to determine mean odds ratio (OR) with 95% credibility intervals (CrIs) for all metaphylactic antimicrobial comparisons. The "upper tier" treatment arms for morbidity d 1 to ≤ 60 included tulathromycin, gamithromycin, and tilmicosin. For BRD mortality cumulative incidence d 1 to closeout and BRD retreatment morbidity d 1 to closeout, classifying the treatment arms into tiers was not possible due to overlapping 95% CrIs. The results of this project accurately identified differences between metaphylactic antimicrobials, and metaphylactic antimicrobial options appear to offer different outcomes on BRD morbidity and mortality odds in feedlot cattle.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Complexo Respiratório Bovino/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Complexo Respiratório Bovino/epidemiologia
Complexo Respiratório Bovino/virologia
Bovinos
Dissacarídeos/administração & dosagem
Compostos Heterocíclicos/administração & dosagem
Incidência
Macrolídeos/administração & dosagem
Tilosina/administração & dosagem
Tilosina/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Disaccharides); 0 (Heterocyclic Compounds); 0 (Macrolides); Q839I13422 (tulathromycin); XL4103X2E3 (tilmicosin); YEF4JXN031 (Tylosin); ZE856183S0 (gamithromycin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.1062


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[PMID]:28282443
[Au] Autor:Murray GM; O'Neill RG; Lee AM; McElroy MC; More SJ; Monagle A; Earley B; Cassidy JP
[Ad] Endereço:Sligo Regional Veterinary Laboratory, Department of Agriculture, Food and Marine, Doonally, Sligo, Ireland.
[Ti] Título:The bovine paranasal sinuses: Bacterial flora, epithelial expression of nitric oxide and potential role in the in-herd persistence of respiratory disease pathogens.
[So] Source:PLoS One;12(3):e0173845, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The bovine paranasal sinuses are a group of complex cavernous air-filled spaces, lined by respiratory epithelium, the exact function of which is unclear. While lesions affecting these sinuses are occasionally reported in cattle, their microbial flora has not been defined. Furthermore, given that the various bacterial and viral pathogens causing bovine respiratory disease (BRD) persist within herds, we speculated that the paranasal sinuses may serve as a refuge for such infectious agents. The paranasal sinuses of clinically normal cattle (n = 99) and of cattle submitted for post-mortem examination (PME: n = 34) were examined by microbial culture, PCR and serology to include bacterial and viral pathogens typically associated with BRD: Mycoplasma bovis, Histophilus somni, Mannheimia haemolytica and Pasteurella multocida, bovine respiratory syncytial virus (BRSV) and bovine parainfluenza-3 virus (BPIV-3). Overall, the paranasal sinuses were either predominantly sterile or did not contain detectable microbes (83.5%: 94.9% of clinically normal and 50.0% of cattle submitted for PME). Bacteria, including BRD causing pathogens, were identified in relatively small numbers of cattle (<10%). While serology indicated widespread exposure of both clinically normal and cattle submitted for PME to BPIV-3 and BRSV (seroprevalences of 91.6% and 84.7%, respectively), PCR identified BPIV-3 in only one animal. To further explore these findings we investigated the potential role of the antimicrobial molecule nitric oxide (NO) within paranasal sinus epithelium using immunohistochemistry. Expression of the enzyme responsible for NO synthesis, inducible nitric oxide synthase (iNOS), was detected to varying degrees in 76.5% of a sub-sample of animals suggesting production of this compound plays a similar protective role in the bovine sinus as it does in humans.
[Mh] Termos MeSH primário: Complexo Respiratório Bovino/virologia
Microbiota
Óxido Nítrico/metabolismo
Seios Paranasais/microbiologia
[Mh] Termos MeSH secundário: Animais
Bactérias/genética
Bactérias/patogenicidade
Complexo Respiratório Bovino/microbiologia
Bovinos
Estudos Transversais
Células Epiteliais/metabolismo
Feminino
Masculino
Microbiota/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Vírus da Parainfluenza 3 Bovina/genética
Vírus da Parainfluenza 3 Bovina/isolamento & purificação
Vírus da Parainfluenza 3 Bovina/patogenicidade
Seios Paranasais/metabolismo
Vírus Sincicial Respiratório Bovino/genética
Vírus Sincicial Respiratório Bovino/isolamento & purificação
Vírus Sincicial Respiratório Bovino/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173845


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[PMID]:28222780
[Au] Autor:Vidic J; Manzano M; Chang CM; Jaffrezic-Renault N
[Ad] Endereço:Virologie et Immunologie Moléculaires, UR892, INRA, Paris Saclay University, 78350, Jouy-en-Josas, France. jasmina.vidic@inra.fr.
[Ti] Título:Advanced biosensors for detection of pathogens related to livestock and poultry.
[So] Source:Vet Res;48(1):11, 2017 Feb 21.
[Is] ISSN:1297-9716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Infectious animal diseases caused by pathogenic microorganisms such as bacteria and viruses threaten the health and well-being of wildlife, livestock, and human populations, limit productivity and increase significantly economic losses to each sector. The pathogen detection is an important step for the diagnostics, successful treatment of animal infection diseases and control management in farms and field conditions. Current techniques employed to diagnose pathogens in livestock and poultry include classical plate-based methods and conventional biochemical methods as enzyme-linked immunosorbent assays (ELISA). These methods are time-consuming and frequently incapable to distinguish between low and highly pathogenic strains. Molecular techniques such as polymerase chain reaction (PCR) and real time PCR (RT-PCR) have also been proposed to be used to diagnose and identify relevant infectious disease in animals. However these DNA-based methodologies need isolated genetic materials and sophisticated instruments, being not suitable for in field analysis. Consequently, there is strong interest for developing new swift point-of-care biosensing systems for early detection of animal diseases with high sensitivity and specificity. In this review, we provide an overview of the innovative biosensing systems that can be applied for livestock pathogen detection. Different sensing strategies based on DNA receptors, glycan, aptamers and antibodies are presented. Besides devices still at development level some are validated according to standards of the World Organization for Animal Health and are commercially available. Especially, paper-based platforms proposed as an affordable, rapid and easy to perform sensing systems for implementation in field condition are included in this review.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/veterinária
Influenza Aviária/diagnóstico
Gado/microbiologia
Gado/virologia
Doenças das Aves Domésticas/diagnóstico
[Mh] Termos MeSH secundário: Animais
Técnicas Biossensoriais/métodos
Bluetongue/diagnóstico
Complexo Respiratório Bovino/diagnóstico
Infecções por Campylobacter/diagnóstico
Infecções por Campylobacter/veterinária
Bovinos
Galinhas/microbiologia
Galinhas/virologia
Infecções por Clostridium/diagnóstico
Infecções por Clostridium/veterinária
Coccidiose/diagnóstico
Coccidiose/virologia
Infecções por Escherichia coli/diagnóstico
Infecções por Escherichia coli/veterinária
Feminino
Febre Aftosa/diagnóstico
Mastite Bovina/diagnóstico
Infecções por Mycoplasma/diagnóstico
Infecções por Mycoplasma/veterinária
Infecções por Orthomyxoviridae/diagnóstico
Infecções por Orthomyxoviridae/veterinária
Salmonelose Animal/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1186/s13567-017-0418-5


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[PMID]:28209213
[Au] Autor:Earley B; Buckham Sporer K; Gupta S
[Ad] Endereço:Animal and Bioscience Research Department,Animal & Grassland Research and Innovation Centre,Teagasc,Grange, Dunsany, Co.Meath C15PW93,Ireland.
[Ti] Título:Invited review: Relationship between cattle transport, immunity and respiratory disease.
[So] Source:Animal;11(3):486-492, 2017 Mar.
[Is] ISSN:1751-732X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The association between transportation and the occurrence of the bovine respiratory disease complex (BRDC) has long been recognised. Many hypotheses regarding this association have been declared through the past decades, and it is agreed upon by most researchers that the multiple stressors that calves experience during transportation result in an overall immunosuppression that allows the respiratory tract to be invaded by numerous opportunistic pathogens. Furthermore, the innate immune cells, neutrophils, may be trapped in a paradox whereby their crucial defence and pathogen-killing activities are counteracted by excessive inflammation and tissue damage that may exacerbate disease, including the BRDC. Neutrophilia in response to glucocorticoids has been attributed to an influx of immature neutrophils newly released from the bone marrow, a decrease in neutrophil margination along endothelial walls, and a decrease in neutrophil apoptosis. Several of these explanations have been confirmed by altered expression of genes and proteins important for neutrophil margination and apoptosis.
[Mh] Termos MeSH primário: Complexo Respiratório Bovino/imunologia
Doenças dos Bovinos/imunologia
Bovinos/fisiologia
Infecções Oportunistas/veterinária
Estresse Fisiológico/fisiologia
Transportes
[Mh] Termos MeSH secundário: Bem-Estar do Animal
Animais
Apoptose
Complexo Respiratório Bovino/etiologia
Bovinos/genética
Bovinos/imunologia
Doenças dos Bovinos/etiologia
Regulação da Expressão Gênica
Imunossupressão/veterinária
Inflamação
Neutrófilos/imunologia
Infecções Oportunistas/etiologia
Infecções Oportunistas/imunologia
Estresse Fisiológico/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1017/S1751731116001622



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