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[PMID]:29256427
[Au] Autor:Ten Doeschate MTI; IJsseldijk LL; Hiemstra S; de Jong EA; Strijkstra A; Gröne A; Begeman L
[Ad] Endereço:Faculty of Veterinary Medicine, Department of Pathobiology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, Netherlands.
[Ti] Título:Quantifying parasite presence in relation to biological parameters of harbour porpoises Phocoena phocoena stranded on the Dutch coast.
[So] Source:Dis Aquat Organ;127(1):49-56, 2017 Dec 19.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Harbour porpoises are often found to be infected by endoparasites in several organs including the lungs and stomach as well as the heart, liver and ears. Nevertheless there is still little knowledge about the impact, ecology, transmission, and virulence of these parasitic infections. Here, we profile the presence of parasites in 4 frequently infected organs (lungs, stomach, liver and ears) in relation to biological parameters of harbour porpoises stranded along the Dutch coastline between December 2008 and December 2013. We found that parasites were common, with prevalence of 68% in lungs, 74.4% in ears, 26% in stomach and 23.5% in liver. We used generalised linear models to further quantify parasite presence in relation to biological data gathered during necropsy (sex, body length and nutritive condition). Body length (used as a proxy for age) was significant in explaining parasite presence for all organs with increasing probability of having the parasite with increasing body length. For the parasitic infections in the ears and stomach the nutritive condition was an additional significant factor, with a higher probability of parasite presence in porpoises in a poorer nutritive condition. The results of this study can be used as a baseline for assessing parasite presence in harbour porpoises and are a first step towards linking parasite infections to basic biological data gathered during necropsy.
[Mh] Termos MeSH primário: Doenças Parasitárias em Animais/parasitologia
Phocoena/parasitologia
[Mh] Termos MeSH secundário: Animais
Otopatias/parasitologia
Otopatias/veterinária
Hepatopatias/parasitologia
Hepatopatias/veterinária
Pneumopatias Parasitárias/veterinária
Países Baixos
Doenças Parasitárias em Animais/patologia
Gastropatias/parasitologia
Gastropatias/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.3354/dao03182


  2 / 7663 MEDLINE  
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[PMID]:29224754
[Au] Autor:Ianacone DC; Smith AF; Casselbrant ML; Ensink RJH; Buchinsky F; Melaku A; Isaacson G
[Ad] Endereço:Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
[Ti] Título:Prevalence of chronic ear disease among HIV+ children in Sub-Saharan Africa.
[So] Source:Int J Pediatr Otorhinolaryngol;103:133-136, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To determine the prevalence of chronic ear disease in HIV+, highly active anti-retroviral therapy (HAART)-treated children and compare this to the prevalence in healthy children of similar age living in a similar setting. INTRODUCTION: From previous clinical work in Ethiopia, we suspected that chronic middle ear disease was common both in the general pediatric population and especially among children with HIV/AIDS. Few studies have examined the prevalence of chronic ear disease in HIV + children, particularly in those treated with HAART. METHODS: Full examination of the head and neck was performed by otolaryngologists. This including cleaning of cerumen, otoscopy and microscopic otoscopy when needed. Patient's medical records were reviewed. Presence or absence of tympanic membrane (TM) perforation (unilateral or bilateral), tympanosclerosis, TM atrophy, otorrhea and/or cholesteatoma was documented. RESULTS: 112 HIV+ and 162 healthy (HIVU) children were included. Prevalence of TM perforations was 17% in the HIV + infected versus 3% in the HIVU (Fisher's-Exact-Test; OR: 7.2, 95% CI 2.5-20, p-value <0.0001). Presence of unilateral TM perforations was 12% in the HIV + population and 2% in the HIVU population (Fisher's-Exact-Test; OR: 6.8, 95% CI 2.0-22, p-value 0.002). The presence of bilateral perforations was 4% in the HIV + population and 1% in the HIVU population (Fisher's-Exact-Test; OR: 6.8, 95% CI 1.1-42, p-value 0.088). In the HIV + cohort, 2% were diagnosed with cholesteatoma compared to 0% in the HIVU population (95% CI HIV+ 0.002-0.06; HIVU 0.0-0.02) and 8% of HIV + subjects had active middle ear discharge, compared to 0% in the HIVU population (95% CI HIV+ 0.04-0.1; HIVU 0.0-0.02). Neither tympanosclerosis nor tympanic membrane atrophy was more frequent in the HIV + population compared to the HIVU population. Persistent or recurrent TM perforation was not more frequent in children with prior tympanoplasty in the HIV + population compared to the HIVU population. CONCLUSION: TM perforations are significantly more common in HAART-treated HIV + children than in healthy, age-matched HIVU population. Otorrhea and cholesteatoma were found only in the HIV + cohort.
[Mh] Termos MeSH primário: Terapia Antirretroviral de Alta Atividade/efeitos adversos
Otopatias/epidemiologia
Infecções por HIV/complicações
[Mh] Termos MeSH secundário: Adolescente
África ao Sul do Saara/epidemiologia
Terapia Antirretroviral de Alta Atividade/métodos
Cerume
Criança
Pré-Escolar
Doença Crônica
Otopatias/complicações
Otopatias/cirurgia
Feminino
Infecções por HIV/tratamento farmacológico
Seres Humanos
Masculino
Otoscopia
Prevalência
Membrana Timpânica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:29078703
[Au] Autor:Gu A; Bauman NM
[Ad] Endereço:1 The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
[Ti] Título:Bipolar Radiofrequency Ablation (Coblation) of External Auditory Canal Lymphatic Malformation and Other Soft Stenoses.
[So] Source:Ann Otol Rhinol Laryngol;126(12):835-838, 2017 Dec.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Soft tissue occlusion of the external auditory canal (EAC) can cause intense pruritis, recurrent foul smelling otorrhea, recurrent otitis externa, and conductive hearing loss. Occlusion of the EAC can be challenging to treat as the area is prone to circumferential scarring. METHODS: We describe the novel use of serial bipolar radiofrequency ablation (coblation) to treat 3 children with complete EAC occlusion from congenital and acquired conditions including lymphedema (1), microcystic lymphatic malformation (1), and venolymphatic malformation (1). RESULTS: Patients underwent a mean of 3 procedures with postoperative EAC stenting (7 days) and antibiotic and steroid aural preparations (10 days). Otologic symptoms resolved in all patients, and their EACs remained patent 14 months after last procedure (range, 4-32 months). One patient experienced a pinpoint tympanic membrane perforation that healed spontaneously 2 weeks later. CONCLUSIONS: Coblation of soft tissue stenosis of the EAC can be an effective treatment for this problematic condition.
[Mh] Termos MeSH primário: Ablação por Cateter
Meato Acústico Externo
Otopatias/cirurgia
Anormalidades Linfáticas/cirurgia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Otopatias/diagnóstico por imagem
Otopatias/etiologia
Feminino
Seres Humanos
Lactente
Anormalidades Linfáticas/diagnóstico por imagem
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417739011


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[PMID]:29069021
[Au] Autor:Mydlak A; Soldacki D; Foroncewicz B; Stopa Z; Powala A; Budlewski T; Paczek L; Mucha K
[Ad] Endereço:aDepartment of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw bDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw cDepartment of Pathology, Medical University of Warsaw dNuclear Medicine Unit, Department of Diagnostic Radiology, Central Clinical Hospital Ministry of Internal Affairs eInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
[Ti] Título:Relapsing polychondritis in a liver transplant recipient: A case report.
[So] Source:Medicine (Baltimore);96(43):e8360, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Relapsing polychondritis (RP) is a multisystemic, progressive disease of unknown etiology characterized by recurrent inflammation and progressive cartilage destruction. It can involve all types of cartilage including ears and nose, tracheobronchial tree, joints, and any other tissue rich in proteoglycans such as heart, eyes, and blood vessels. Recurrent chondritis can be life-threatening if the respiratory tract, heart valves, or blood vessels are affected. To date there is no data in the literature on the post solid organ transplantation RP. PATIENT CONCERNS: We present a 59-year-old male liver transplant recipient with primary sclerosing cholangitis who developed RP of the earlobes and nose despite post-transplant immunosuppression. DIAGNOSES: Based on the clinical criteria, scintigraphy and biopsy from the left auricle his condition was diagnosed as RP. INTERVENTIONS: Pulses of methylprednisolone followed by high-dose oral steroids along with azathioprine were administered. OUTCOMES: Such therapy diminished local cartilage inflammation, improved patient's general condition and the laboratory results. Significant loss of ear cartilage and characteristic "saddlenose" were observed after remission of acute symptoms. The control scintigraphy proved very good treatment response. LESSONS: To the best of our knowledge this is the first report on the RP in liver transplant recipient. Based on our patient presentation, we suggest that RP should be suspected in any transplant recipient with cartilage inflammation, and that the Michet's clinical criteria and scintigraphy seem to be the best diagnostic tools for solid organ transplant recipients suspected of RP.
[Mh] Termos MeSH primário: Otopatias/etiologia
Transplante de Fígado/efeitos adversos
Doenças Nasais/etiologia
Policondrite Recidivante/etiologia
[Mh] Termos MeSH secundário: Colangite Esclerosante/cirurgia
Cartilagem da Orelha/patologia
Otopatias/patologia
Seres Humanos
Masculino
Meia-Idade
Cartilagens Nasais/patologia
Doenças Nasais/patologia
Policondrite Recidivante/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008360


  5 / 7663 MEDLINE  
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[PMID]:28975810
[Au] Autor:Harju T; Kivekäs I; Numminen J; Rautiainen M
[Ad] Endereço:1 Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland.
[Ti] Título:Eustachian Tube Dysfunction-Related Symptoms in Chronic Nasal Obstruction Caused by Inferior Turbinate Enlargement.
[So] Source:Ann Otol Rhinol Laryngol;126(12):798-803, 2017 Dec.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate the relationship between chronic nasal obstruction caused by inferior turbinate enlargement and Eustachian tube dysfunction-related symptoms using the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) as an assessment method. METHODS: A total of 80 adults were enrolled. Group 1 comprised consecutive patients with enlarged inferior turbinates and group 2 comprised healthy controls. The ETDQ-7 scores and tympanometry results of both groups were analyzed and compared. RESULTS: The median total scores of the ETDQ-7 in groups 1 and 2 were 1.9 (interquartile range, 1.4-2.8) and 1.1 (interquartile range, 1.0-1.7), respectively ( P < .001). There was no significant difference in the abnormal tympanometry results between the groups. There was no significant difference in the ETDQ-7 total score between the patients with allergic sensitization and other patients in group 1. CONCLUSIONS: Patients with inferior turbinate enlargement have more symptoms related to Eustachian tube dysfunction than healthy controls. Most patients with Eustachian tube dysfunction had normal tympanometry and normal otoscopy, which indicates a baro-challenge-induced Eustachian tube dysfunction. Whether the patient has allergic sensitization or not does not seem to cause a difference in symptoms related to Eustachian tube dysfunction.
[Mh] Termos MeSH primário: Otopatias/etiologia
Tuba Auditiva
Obstrução Nasal/etiologia
Conchas Nasais/patologia
[Mh] Termos MeSH secundário: Testes de Impedância Acústica
Adulto
Estudos de Casos e Controles
Doença Crônica
Otopatias/patologia
Feminino
Seres Humanos
Hipertrofia
Masculino
Meia-Idade
Otoscopia
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417735538


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[PMID]:28895462
[Au] Autor:Jelicic T; Savage JR; Aron M
[Ad] Endereço:1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Centre Hospitalier Université de Sherbrooke, Sherbrooke, Canada.
[Ti] Título:Is Hospitalization Necessary after Ear Surgery? A National Survey and Retrospective Review of Postoperative Events.
[So] Source:Otolaryngol Head Neck Surg;157(4):707-715, 2017 Oct.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective First, to survey our national otolaryngology colleagues on their postoperative care habits (hospitalization vs day surgery) after elective middle ear surgery. Second, to evaluate the necessity of hospitalization and safety of day surgery after these procedures. Methods A national survey regarding postoperative habits after elective middle ear surgery was launched. Then, the cases of all patients having undergone these surgical procedures at our center between 2010 and 2016 were reviewed. They were divided into 2 groups: hospitalization and day surgery. Postoperative events during hospitalization and rate of consultation/readmission for day surgery were recorded. Results Heterogeneity in postoperative habits for most elective otologic surgery exists among otolaryngologists. For tympanoplasty, however, day surgery was uniformly favored. At our institution, 88.6% of hospitalization patients had no complications during their stay. Complications noted for others were nausea (7.2%), bleeding (3.1%), hematoma (0.5%), and sensorineural hearing loss (0.5%). In the day surgery group, 3.0% consulted within 48 hours following their procedure, and the readmission rate was 1.3%. Nausea was the only cause for readmission, and stapes surgery accounted for 100% of readmissions. Discussion Most elective middle ear surgery can be safely performed as day care. Hospitalization does not provide care that could not have been provided at home in the majority of cases. Overnight hospital stay may be considered for stapes surgery. Implications for Practice Day surgery for elective middle ear surgery is sufficient for most cases. Transferring these cases to day care should lower costs to our health care system and increase bed availability.
[Mh] Termos MeSH primário: Otopatias/cirurgia
Procedimentos Cirúrgicos Eletivos/métodos
Hospitalização/estatística & dados numéricos
Procedimentos Cirúrgicos Otológicos/métodos
Vigilância da População
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Período Pós-Operatório
Quebeque
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817726307


  7 / 7663 MEDLINE  
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[PMID]:28871844
[Au] Autor:Anschuetz L; Bonali M; Guarino P; Fabbri FB; Alicandri-Ciufelli M; Villari D; Caversaccio M; Presutti L
[Ad] Endereço:1 Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
[Ti] Título:Management of Bleeding in Exclusive Endoscopic Ear Surgery: Pilot Clinical Experience.
[So] Source:Otolaryngol Head Neck Surg;157(4):700-706, 2017 Oct.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective Transcanal exclusive endoscopic ear surgery requires the management of the endoscope and the surgical instruments in the external auditory canal. Bleeding in this narrow space is one of the most challenging issues, especially for novice endoscopic ear surgeons. We aim to assess the severity and occurrence of bleeding and describe strategies to control the bleeding during endoscopic ear surgery. We hypothesize that bleeding is reasonably controllable in endoscopic ear surgery. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods We retrospectively assessed 104 consecutive cases of exclusive endoscopic ear surgery at the University Hospital of Modena, Italy. The surgical videos and the patient charts were carefully investigated and analyzed. Results Hemostatic agents included injection of diluted epinephrine (1:200,000, 2% mepivacaine), cottonoids soaked with epinephrine (1:1000), mono- or bipolar cautery, washing with hydrogen peroxide, and self-suctioning instruments. The localization of bleeding in the external auditory canal was most frequently the posterior superior part, and inside of the middle ear, it was the pathology itself. Statistical analysis revealed significant differences comparing the mean arterial pressure and the type of intervention among bleeding scores. Conclusion The management of bleeding in endoscopic ear surgery is feasible through widely available hemostatic agents in reasonable frequency. This study gives an instructive overview on how to manage the bleeding in the exclusive endoscopic technique. Even the highest bleeding scores could be managed in an exclusively endoscopic technique.
[Mh] Termos MeSH primário: Perda Sanguínea Cirúrgica/prevenção & controle
Otopatias/cirurgia
Técnicas Hemostáticas
Cirurgia Endoscópica por Orifício Natural/efeitos adversos
Procedimentos Cirúrgicos Otológicos/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Meato Acústico Externo
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817726982


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[PMID]:28838247
[Au] Autor:Hamed SA
[Ad] Endereço:a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.
[Ti] Título:The auditory and vestibular toxicities induced by antiepileptic drugs.
[So] Source:Expert Opin Drug Saf;16(11):1281-1294, 2017 Nov.
[Is] ISSN:1744-764X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Epilepsy is a chronic medical disease in one third of patients and is associated with comorbid adverse somatic conditions due to epilepsy itself or its long-term treatment with antiepileptic drugs (AEDs). Data from experimental, cross-sectional and prospective studies have evidence for the deleterious effect of some AEDs on the auditory and vestibular systems. These abnormalities may be reversible or irreversible. Areas covered: This article review the evidence that long-term treatment with some antiepileptic drugs (AEDs) [e.g. carbamazepine, phenytoin, valproate, lamotrigine, gabapentin, vigabatrin and oxcarbazepine] (even in therapeutic drug doses) may result in tinnitus, phonophobia, sensorineural hearing loss, dizziness, ataxia, disequilibrium, imbalance, nystagmus, abnormalities in saccadic and pursuit eye movements and delayed conduction within the cochlea, auditory nerve and brainstem auditory pathways evidenced by abnormalities in Brainstem auditory evoked potentials and nystagmography recordings indicating auditory and central and/or peripheral vestibular dysfunctions. Expert opinion: Identification of monitoring of patients at high risk for developing audio-vestibular manifestations is necessary for appropriate preventive and therapeutic measures.
[Mh] Termos MeSH primário: Anticonvulsivantes/efeitos adversos
Otopatias/induzido quimicamente
Doenças Vestibulares/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Anticonvulsivantes/administração & dosagem
Monitoramento de Medicamentos/métodos
Otopatias/fisiopatologia
Epilepsia/tratamento farmacológico
Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos
Seres Humanos
Fatores de Risco
Fatores de Tempo
Doenças Vestibulares/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1080/14740338.2017.1372420


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[PMID]:28802382
[Au] Autor:Koçak I; Sarac S; Aydogan E; Sentürk E; Akakin D; Koroglu K; Özer ÖF
[Ad] Endereço:Department of Otolaringology, Koç University Hospital, Istanbul, Turkey. Electronic address: ikocak@kuh.ku.edu.tr.
[Ti] Título:Evaluation of the possible protective role of naringenin on gentamicin-induced ototoxicity: A preliminary study.
[So] Source:Int J Pediatr Otorhinolaryngol;100:247-253, 2017 Sep.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this study is to evaluate the possible protective role of naringenin in gentamicin-induced ototoxicity through an audiological, biochemical and histopathological evaluation. METHODS: This study was conducted on 32 adult male rats that were randomized into 4 groups(control, gentamicin, naringenin + gentamicin, and naringenin). Naringenin was given to the rats via oral gavage in a dose of 50 mg/kg/day during the 14 day study period. Gentamicin was given by the intraperitoneal route in a dose of 120 mg/kg/day. Audiological assessment was performed by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) measurements, applied to all rats at the beginning of the study, and also on day 14. Biochemical parameters were calculated on day 14 to evaluate the oxidative and antioxidative status. Their cochleae were removed and examined histopathologically, also on day 14. The cochlea of animals were evaluated with the terminal deoxynucleotidyl transferase-mediated dUTPbiotin nick end labeling (TUNEL) method for apoptosis. RESULTS: On days 14, DPOAE values and ABR thresholds were preserved in group 3(naringenin + gentamicin) when compared with group 2(gentamicin)(p < 0.008). The total oxidant status values and oxidative stress index values were significantly higher in group 2(gentamicin) than in other groups (p < 0.008). The total antioxidant status value was significantly higher in group 3(naringenin + gentamicin) and group 4(naringenin) than in group 2(gentamicin)(p < 0.008). The number of TUNEL positive cells in both the organ of Corti and the stria vascularis were found to be statistically lower in group 3(naringenin + gentamicin) than in group 2(gentamicin)(p < 0.05). CONCLUSION: Our study has demonstrated that the ototoxic effect generated by gentamicin could be ameliorated with the concurrent use of naringenin.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Otopatias/induzido quimicamente
Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos
Flavanonas/farmacologia
Gentamicinas/efeitos adversos
Emissões Otoacústicas Espontâneas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Cóclea/efeitos dos fármacos
Orelha Interna/efeitos dos fármacos
Marcação In Situ das Extremidades Cortadas
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Flavanones); 0 (Gentamicins); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


  10 / 7663 MEDLINE  
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[PMID]:28802363
[Au] Autor:Ping C; Yanling H; Youhua W; Shufen W; Zhinan W; Zhongfang X
[Ad] Endereço:ENT Department of Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, China. Electronic address: aeiuo@163.com.
[Ti] Título:Epidemiology of cerumen impaction among municipal kindergartens children in Wuhan, China.
[So] Source:Int J Pediatr Otorhinolaryngol;100:154-156, 2017 Sep.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the epidemiology of cerumen impaction among children of municipal kindergartens in Wuhan. METHODS: The ear canal of children of municipal kindergartens in Wuhan was examined using an electric otoscope by the same otologist in 2005, 2006 and 2012, with age, gender, ears and the nature of cerumen (dry cerumen or wet cerumen) recorded. A chi-square test was performed to investigate for significant differences between cerumen impaction rates and the recorded variables. RESULTS: A total of 1,214, 1863 and 5205 children were examined in 2005, 2006 and 2012, and cerumen impaction prevalence rates for each year were 17.2%, 15.4% and 10%, respectively. Prevalence of cerumen impaction was significantly lower in 2012 than in 2005 or 2006. In 2005, dry cerumen impaction accounted for 22.2% of the total dry cerumen, while wet cerumen impaction only accounted for 5% of the total wet cerumen, showing a statistically significant difference. CONCLUSION: The prevalence of cerumen impaction among children of kindergartens in Wuhan is higher than 10%, and children with dry cerumen are more prone to cerumen impaction. Annual otological examination of kindergarten children is recommended. And improved community ear health promotion activities should reduce the avoidable prevalence of cerumen impaction in pediatric population.
[Mh] Termos MeSH primário: Otopatias/epidemiologia
[Mh] Termos MeSH secundário: Cerume
Criança
Pré-Escolar
China/epidemiologia
Meato Acústico Externo
Feminino
Seres Humanos
Masculino
Otoscópios
Prevalência
Estudos Retrospectivos
Instituições Acadêmicas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE



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