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  1 / 1925 MEDLINE  
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Melaragno, Maria Isabel
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[PMID]:29258104
[Au] Autor:Malinverni ACM; Yamashiro Coelho ÉM; Chen K; Colovati ME; Soares Pinho Cernach MC; Bragagnolo S; Melaragno MI
[Ad] Endereço:Genetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.
[Ti] Título:Deletion 21pterq22.11: Report of a Patient with Dysmorphic Features, Hypertonia, and Café-au-Lait Macules and Review of the Literature.
[So] Source:Cytogenet Genome Res;153(2):81-85, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Partial monosomy 21 results in a great variability of clinical features that may be associated with the size and location of the deletion. In this study, we report a 22-month-old girl who showed a 45,XX,add(12)(p13)dn,-21 karyotype. The final cytogenomic result was 45,XX,der(12)t(12;21)(p13;q22.11) dn,-21.arr[hg19] 21q11.2q22.11(14824453_33868129)×1 revealing a deletion from 21pter to 21q22.11. Clinical manifestation of the patient included hypertonia, a long philtrum, epicanthic folds, low-set ears, and café-au-lait macules - a phenotype considered as mild despite the relatively large size of the deletion compared to patients from the literature.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/genética
Manchas Café com Leite/genética
Deleção Cromossômica
Cromossomos Humanos Par 21/ultraestrutura
Face/anormalidades
Hipertonia Muscular/genética
[Mh] Termos MeSH secundário: Cromossomos Humanos Par 21/genética
Deficiências do Desenvolvimento/genética
Feminino
Perda Auditiva Bilateral/genética
Seres Humanos
Recém-Nascido
Cariotipagem
Fenótipo
Escoliose/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1159/000485282


  2 / 1925 MEDLINE  
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[PMID]:29248929
[Au] Autor:Amasdl S; Smaili W; Natiq A; Hassani A; Sbiti A; Agadr A; Sanlaville D; Sefiani A
[Ad] Endereço:Centre de Génomique Humaine, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Morocco.
[Ti] Título:Familial X/Y Translocation Encompassing ARSE in Two Moroccan Siblings with Sensorineural Deafness.
[So] Source:Cytogenet Genome Res;153(2):66-72, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Unbalanced translocations involving X and Y chromosomes are rare and associated with a contiguous gene syndrome. The clinical phenotype is heterogeneous including mainly short stature, chondrodysplasia punctata, ichthyosis, hypogonadism, and intellectual disability. Here, we report 2 brothers with peculiar gestalt, short stature, and hearing loss, who harbor an X/Y translocation. Physical examination, brainstem acoustic potential evaluation, bone age, hormonal assessment, and X-ray investigations were performed. Because of their dysmorphic features, karyotyping, FISH, and aCGH were carried out. The probands had short stature, hypertelorism, midface hypoplasia, sensorineural hearing loss, normal intelligence as well as slight radial and ulnar bowing with brachytelephalangy. R-banding identified a derivative X chromosome with an abnormally expanded short arm. The mother was detected as a carrier of the same aberrant X chromosome. aCGH disclosed a 3.1-Mb distal deletion of chromosome region Xp22.33pter. This interval encompasses several genes, especially the short stature homeobox (SHOX) and arylsulfatase (ARSE) genes. The final karyotype of the probands was: 46,Y,der(X),t(X;Y)(p22;q12).ish der(X)(DXYS129-,DXYS153-)mat.arr[hg19] Xp22.33(61091_2689408)×1mat,Xp22.33(2701273_3258404)×0mat,Yq11.222q12 (21412851_59310245)×2. Herein, we describe a Moroccan family with a maternally inherited X/Y translocation and discuss the genotype-phenotype correlations according to the deleted genes.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/genética
Arilsulfatases/genética
Cromossomos Humanos X/genética
Cromossomos Humanos Y/genética
Perda Auditiva Bilateral/genética
Perda Auditiva Neurossensorial/genética
Translocação Genética
[Mh] Termos MeSH secundário: Arilsulfatases/deficiência
Cromossomos Humanos X/ultraestrutura
Cromossomos Humanos Y/ultraestrutura
Consanguinidade
Feminino
Seres Humanos
Hipertelorismo/genética
Recém-Nascido
Cariotipagem
Masculino
Meia-Idade
Marrocos
Linhagem
Fenótipo
Rádio (Anatomia)/anormalidades
Escoliose/genética
Irmãos
Ulna/anormalidades
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.1.6.- (ARSE protein, human); EC 3.1.6.1 (Arylsulfatases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171218
[St] Status:MEDLINE
[do] DOI:10.1159/000485071


  3 / 1925 MEDLINE  
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[PMID]:29256573
[Au] Autor:Schilder AG; Chong LY; Ftouh S; Burton MJ
[Ad] Endereço:evidENT, Ear Institute, Faculty of Brain Sciences, University College London, 330 Grays Inn Road, London, UK, WC1X 8DA.
[Ti] Título:Bilateral versus unilateral hearing aids for bilateral hearing impairment in adults.
[So] Source:Cochrane Database Syst Rev;12:CD012665, 2017 12 19.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acquired hearing loss is common and its incidence increases markedly with age. In most people, 'age-related' hearing loss is sensorineural (due to the loss of cochlear hair cells) and bilateral, affecting both ears to the same degree. Hearing loss categorised as mild, moderate or severe is primarily managed with hearing aids. People with bilateral hearing loss may be offered one aid, fitted to one specific ear, or two aids fitted to both ears. There is uncertainty about the relative benefits to people with hearing loss of these different strategies. OBJECTIVES: To assess the effects of bilateral versus unilateral hearing aids in adults with a bilateral hearing impairment. SEARCH METHODS: The Cochrane ENT Information Specialist searched the ENT Trials Register; Cochrane Register of Studies Online; PubMed; Ovid Embase; CINAHL; Web of Science; ClinicalTrials.gov; ICTRP and additional sources for published and unpublished trials. The date of the search was 8 June 2017. SELECTION CRITERIA: Randomised controlled trials (RCTs) comparing the fitting of two versus one ear-level acoustic hearing aids in adults (over 18 years) with a bilateral hearing impairment, both ears being eligible for hearing aids. DATA COLLECTION AND ANALYSIS: We used the standard methodological procedures expected by Cochrane. Our primary outcomes were patient preference for bilateral or unilateral aids, hearing-specific health-related quality of life and adverse effects (pain or discomfort in the ear, initiation or exacerbation of middle or outer ear infection). Secondary outcomes included: usage of hearing aids (as measured by, for example, data logging or battery consumption), generic health-related quality of life, listening ability and audiometric benefit measured as binaural loudness summation. We used GRADE to assess the quality of the evidence for each outcome; this is indicated in italics. MAIN RESULTS: We included four cross-over RCTs with a total of 209 participants, ranging in age from 23 to 85 and with a preponderance of men. All the studies allowed the use of hearing aids for a total period of at least eight weeks before questions on preference were asked. All studies recruited patients with bilateral hearing loss but there was considerable variation in the types and degree of sensorineural hearing loss that the participants were experiencing.Three of the studies were published before the mid-1990s whereas the fourth study was published in 2011. Therefore, only the most recent study used hearing aids incorporating technology comparable to that currently readily available in high-income settings. Of the four studies, two were conducted in the UK in National Health Service (NHS - public sector) patients: one recruited patients from primary care with hearing loss detected by a screening programme whereas the other recruited patients who had been referred by their primary care practitioner to an otolaryngology department for hearing aids. The other two studies were conducted in the United States: one study recruited only military personnel or veterans with noise-induced hearing loss whereas about half of the participants in the other study were veterans.Only one primary outcome (patient preference) was reported in all studies. The percentage of patients who preferred bilateral hearing aids varied between studies: this was 54% (51 out of 94 participants), 39% (22 out of 56), 55% (16 out of 29) and 77% (23 out of 30), respectively. We have not combined the data from these four studies. The evidence for this outcome is of very low quality.The other outcomes of interest were not reported in the included studies. AUTHORS' CONCLUSIONS: This review identified only four studies comparing the use of one hearing aid with two. The studies were small and included participants of widely varying ages. There was also considerable variation in the types and degree of sensorineural hearing loss that the participants were experiencing.For the most part, the types of hearing aid evaluated would now be regarded, in high-income settings, as 'old technology', with only one study looking at 'modern' digital aids. However, the relevance of this is uncertain, as this review did not evaluate the differences in outcomes between the different types of technology.We were unable to pool data from the four studies and the very low quality of the evidence leads us to conclude that we do not know if people with hearing loss have a preference for one aid or two. Similarly, we do not know if hearing-specific health-related quality of life, or any of our other outcomes, are better with bilateral or unilateral aids.
[Mh] Termos MeSH primário: Auxiliares de Audição
Perda Auditiva Bilateral/reabilitação
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Correção de Deficiência Auditiva/instrumentação
Correção de Deficiência Auditiva/métodos
Estudos Cross-Over
Feminino
Auxiliares de Audição/utilização
Seres Humanos
Masculino
Meia-Idade
Preferência do Paciente
Qualidade de Vida
Ensaios Clínicos Controlados Aleatórios como Assunto
Localização de Som
Inteligibilidade da Fala
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD012665.pub2


  4 / 1925 MEDLINE  
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[PMID]:29287861
[Au] Autor:Dhondt CMC; Swinnen FKR; Dhooge IJM
[Ad] Endereço:Department of Ear Nose Throat, Ghent University, De Pintelaan 185 (1P1), B - 9000, Ghent, Belgium. Electronic address: Cleo.Dhondt@UGent.be.
[Ti] Título:Bilateral cochlear implantation or bimodal listening in the paediatric population: Retrospective analysis of decisive criteria.
[So] Source:Int J Pediatr Otorhinolaryngol;104:170-177, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: In children with bilateral severe to profound hearing loss, bilateral hearing can be achieved by either bimodal stimulation (CIHA) or bilateral cochlear implantation (BICI). The aim of this study was to analyse the audiologic test protocol that is currently applied to make decisions regarding the bilateral hearing modality in the paediatric population. METHODS: Pre- and postoperative audiologic test results of 21 CIHA, 19 sequential BICI and 12 simultaneous BICI children were examined retrospectively. RESULTS: Deciding between either simultaneous BICI or unilateral implantation was mainly based on the infant's preoperative Auditory Brainstem Response thresholds. Evolution from CIHA to sequential BICI was mainly based on the audiometric test results in the contralateral (hearing aid) ear after unilateral cochlear implantation. Preoperative audiometric thresholds in the hearing aid ear were significantly better in CIHA versus sequential BICI children (p < 0.001 and p = 0.001 in unaided and aided condition, respectively). Decisive values obtained in the hearing aid ear in favour of BICI were: An average hearing threshold measured at 0.5, 1, 2 and 4 kHz of at least 93 dB HL without, and at least 52 dB HL with hearing aid together with a 40% aided speech recognition score and a 70% aided score on the phoneme discrimination subtest of the Auditory Speech Sounds Evaluation test battery. CONCLUSIONS: Although pure tone audiometry offers no information about bimodal benefit, it remains the most obvious audiometric evaluation in the decision process on the mode of bilateral stimulation in the paediatric population. A theoretical test protocol for adequate evaluation of bimodal benefit in the paediatric population is proposed.
[Mh] Termos MeSH primário: Implante Coclear/métodos
Implantes Cocleares/efeitos adversos
Perda Auditiva Bilateral/cirurgia
[Mh] Termos MeSH secundário: Audiometria de Tons Puros
Percepção Auditiva
Criança
Pré-Escolar
Tomada de Decisões
Potenciais Evocados Auditivos do Tronco Encefálico
Feminino
Seres Humanos
Lactente
Masculino
Estudos Retrospectivos
Percepção da Fala/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  5 / 1925 MEDLINE  
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[PMID]:29258540
[Au] Autor:Choi HJ; Lee JS; Yu S; Cha DH; Gee HY; Choi JY; Lee JD; Jung J
[Ad] Endereço:Department of Otorhinolaryngology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, South Korea.
[Ti] Título:Whole-exome sequencing identified a missense mutation in WFS1 causing low-frequency hearing loss: a case report.
[So] Source:BMC Med Genet;18(1):151, 2017 12 19.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Low-frequency nonsyndromic hearing loss (LF-NSHL) is a rare, inherited disorder. Here, we report a family with LF-NSHL in whom a missense mutation was found in the Wolfram syndrome 1 (WFS1) gene. CASE PRESENTATION: Family members underwent audiological and imaging evaluations, including pure tone audiometry and temporal bone computed tomography. Blood samples were collected from two affected and two unaffected subjects. To determine the genetic background of hearing loss in this family, genetic analysis was performed using whole-exome sequencing. Among 553 missense variants, c.2419A → C (p.Ser807Arg) in WFS1 remained after filtering and inspection of whole-exome sequencing data. This missense mutation segregated with affected status and demonstrated an alteration to an evolutionarily conserved amino acid residue. Audiological evaluation of the affected subjects revealed nonprogressive LF-NSHL, with early onset at 10 years of age, but not to a profound level. CONCLUSION: This is the second report to describe a pathological mutation in WFS1 among Korean patients and the second to describe the mutation in a different ethnic background. Given that the mutation was found in independent families, p.S807R possibly appears to be a "hot spot" in WFS1, which is associated with LF-NSHL.
[Mh] Termos MeSH primário: Surdez/genética
Perda Auditiva Bilateral/genética
Proteínas de Membrana/genética
Mutação de Sentido Incorreto/genética
[Mh] Termos MeSH secundário: Adolescente
Grupo com Ancestrais do Continente Asiático/genética
Audiometria
Feminino
Seres Humanos
Masculino
Meia-Idade
República da Coreia
Osso Temporal/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Sequenciamento Completo do Exoma
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (wolframin protein)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171231
[Lr] Data última revisão:
171231
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0511-7


  6 / 1925 MEDLINE  
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[PMID]:28887665
[Au] Autor:Scobioala S; Parfitt R; Matulat P; Kittel C; Ebrahimi F; Wolters H; Am Zehnhoff-Dinnesen A; Eich HT
[Ad] Endereço:Department of Radiotherapy and Radiooncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Muenster, Germany. Sergiu.Scobioala@ukmuenster.de.
[Ti] Título:Impact of radiation technique, radiation fraction dose, and total cisplatin dose on hearing : Retrospective analysis of 29 medulloblastoma patients.
[Ti] Título:Effekte von Bestrahlungstechnik, Fraktionierung und Cisplatin-Gesamtdosis auf das Hörvermögen : Retrospektive Analyse von 29 Patienten mit Medulloblastom..
[So] Source:Strahlenther Onkol;193(11):910-920, 2017 Nov.
[Is] ISSN:1439-099X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To analyze the incidence and degree of sensorineural hearing loss (SNHL) resulting from different radiation techniques, fractionation dose, mean cochlear radiation dose (D ), and total cisplatin dose. MATERIAL AND METHODS: In all, 29 children with medulloblastoma (58 ears) with subclinical pretreatment hearing thresholds participated. Radiotherapy (RT) and cisplatin had been applied sequentially according to the HIT MED Guidance. Audiological outcomes up to the latest follow-up (median 2.6 years) were compared. RESULTS: Bilateral high-frequency SNHL was observed in 26 patients (90%). No significant differences were found in mean hearing threshold between left and right ears at any frequency. A significantly better audiological outcome (p < 0.05) was found after tomotherapy at the 6 kHz bone-conduction threshold (BCT) and left-sided 8 kHz air-conduction threshold (ACT) than after a combined radiotherapy technique (CT). Fraction dose was not found to have any impact on the incidence, degree, and time-to-onset of SNHL. Patients treated with CT had a greater risk of SNHL at high frequencies than tomotherapy patients even though D was similar. Increase in severity of SNHL was seen when the total cisplatin dose reached above 210 mg/m , with the highest abnormal level found 8-12 months after RT regardless of radiation technique or fraction dose. CONCLUSION: The cochlear radiation dose should be kept as low as possible in patients who receive simultaneous cisplatin-based chemotherapy. The risk of clinically relevant HL was shown when D exceeds 45 Gy independent of radiation technique or radiation regime. Cisplatin ototoxicity was shown to have a dose-dependent effect on bilateral SNHL, which was more pronounced in higher frequencies.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/terapia
Quimiorradioterapia/efeitos adversos
Quimiorradioterapia/métodos
Cisplatino/administração & dosagem
Cisplatino/efeitos adversos
Fracionamento de Dose
Perda Auditiva Bilateral/etiologia
Perda Auditiva Neurossensorial/etiologia
Meduloblastoma/terapia
Lesões por Radiação/etiologia
Radioterapia de Intensidade Modulada/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Limiar Auditivo/efeitos dos fármacos
Limiar Auditivo/efeitos da radiação
Criança
Pré-Escolar
Terapia Combinada
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE
[do] DOI:10.1007/s00066-017-1205-y


  7 / 1925 MEDLINE  
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[PMID]:28802360
[Au] Autor:Jamshidi A; Glidewell C; Murnick J; Magge S; Reilly BK
[Ad] Endereço:The George Washington University, School of Medicine and Health Sciences, 2300 I St NW, Washington, D.C, 20037, United States. Electronic address: ariajams@gmail.com.
[Ti] Título:Resolution of bilateral sensorineural hearing loss following ventriculoperitoneal shunt and literature review.
[So] Source:Int J Pediatr Otorhinolaryngol;100:141-144, 2017 Sep.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study is to highlight the relationship between obstructive hydrocephalus, changes in intracranial pressure, and sensorineural hearing loss. METHODS: A case of a 10-month old infant with sensorineural hearing loss secondary to obstructive hydrocephalus is reported. A literature review, with a focus on sensorineural hearing loss in the setting of changes in intracranial pressure, was performed. RESULTS: The authors report the case of a 10-month old infant with metopic and bicoronal craniosynostosis who presented with bilateral moderately severe sensorineural hearing loss after failing newborn hearing screening. Imaging subsequently demonstrated obstructive hydrocephalus, which was treated with the insertion of a VP shunt. The patient had immediate improvement of her hearing post-operatively, with repeat hearing tests showed resolution of her hearing loss. CONCLUSION: Sensorineural hearing loss is a rare complication of hydrocephalus, but changes in intracranial pressure should be considered in the differential diagnosis. We put forth a flow diagram illustrating the hypothesized relationship between intracranial pressures, alterations in the levels of cochlear fluid, and hearing.
[Mh] Termos MeSH primário: Craniossinostoses/cirurgia
Perda Auditiva Bilateral/cirurgia
Perda Auditiva Neurossensorial/cirurgia
Hidrocefalia/cirurgia
Derivação Ventriculoperitoneal/métodos
[Mh] Termos MeSH secundário: Cóclea/fisiopatologia
Craniossinostoses/complicações
Feminino
Perda Auditiva Bilateral/etiologia
Perda Auditiva Neurossensorial/etiologia
Testes Auditivos
Seres Humanos
Hidrocefalia/complicações
Lactente
Imagem por Ressonância Magnética
Próteses e Implantes/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


  8 / 1925 MEDLINE  
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[PMID]:28689189
[Au] Autor:Yoshinaga-Itano C; Sedey AL; Wiggin M; Chung W
[Ad] Endereço:Institute of Cognitive Science, University of Colorado Boulder, Boulder, Colorado; christie.yoshi@colorado.edu.
[Ti] Título:Early Hearing Detection and Vocabulary of Children With Hearing Loss.
[So] Source:Pediatrics;140(2), 2017 Aug.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: To date, no studies have examined vocabulary outcomes of children meeting all 3 components of the Early Hearing Detection and Intervention (EHDI) guidelines (hearing screening by 1 month, diagnosis of hearing loss by 3 months, and intervention by 6 months of age). The primary purpose of the current study was to examine the impact of the current EHDI 1-3-6 policy on vocabulary outcomes across a wide geographic area. A secondary goal was to confirm the impact of other demographic variables previously reported to be related to language outcomes. METHODS: This was a cross-sectional study of 448 children with bilateral hearing loss between 8 and 39 months of age (mean = 25.3 months, SD = 7.5 months). The children lived in 12 different states and were participating in the National Early Childhood Assessment Project. RESULTS: The combination of 6 factors in a regression analysis accounted for 41% of the variance in vocabulary outcomes. Vocabulary quotients were significantly higher for children who met the EHDI guidelines, were younger, had no additional disabilities, had mild to moderate hearing loss, had parents who were deaf or hard of hearing, and had mothers with higher levels of education. CONCLUSIONS: Vocabulary learning may be enhanced with system improvements that increase the number of children meeting the current early identification and intervention guidelines. In addition, intervention efforts need to focus on preventing widening delays with chronological age, assisting mothers with lower levels of education, and incorporating adults who are deaf/hard-of-hearing in the intervention process.
[Mh] Termos MeSH primário: Diagnóstico Precoce
Perda Auditiva Bilateral/diagnóstico
Perda Auditiva Bilateral/reabilitação
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Transtornos do Desenvolvimento da Linguagem/reabilitação
Triagem Neonatal
Vocabulário
[Mh] Termos MeSH secundário: Pré-Escolar
Correção de Deficiência Auditiva
Estudos Transversais
Intervenção Médica Precoce
Feminino
Seguimentos
Fidelidade a Diretrizes
Seres Humanos
Lactente
Recém-Nascido
Masculino
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


  9 / 1925 MEDLINE  
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[PMID]:28688548
[Au] Autor:Marsella P; Scorpecci A; Cartocci G; Giannantonio S; Maglione AG; Venuti I; Brizi A; Babiloni F
[Ad] Endereço:Audiology and Otosurgery Unit, Bambino Gesù Pediatric Hospital, Italy.
[Ti] Título:EEG activity as an objective measure of cognitive load during effortful listening: A study on pediatric subjects with bilateral, asymmetric sensorineural hearing loss.
[So] Source:Int J Pediatr Otorhinolaryngol;99:1-7, 2017 Aug.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Deaf subjects with hearing aids or cochlear implants generally find it challenging to understand speech in noisy environments where a great deal of listening effort and cognitive load are invested. In prelingually deaf children, such difficulties may have detrimental consequences on the learning process and, later in life, on academic performance. Despite the importance of such a topic, currently, there is no validated test for the assessment of cognitive load during audiological tasks. Recently, alpha and theta EEG rhythm variations in the parietal and frontal areas, respectively, have been used as indicators of cognitive load in adult subjects. The aim of the present study was to investigate, by means of EEG, the cognitive load of pediatric subjects affected by asymmetric sensorineural hearing loss as they were engaged in a speech-in-noise identification task. METHODS: Seven children (4F and 3M, age range = 8-16 years) affected by asymmetric sensorineural hearing loss (i.e. profound degree on one side, mild-to-severe degree on the other side) and using a hearing aid only in their better ear, were included in the study. All of them underwent EEG recording during a speech-in-noise identification task: the experimental conditions were quiet, binaural noise, noise to the better hearing ear and noise to the poorer hearing ear. The subjects' Speech Recognition Thresholds (SRT) were also measured in each test condition. The primary outcome measures were: frontal EEG Power Spectral Density (PSD) in the theta band and parietal EEG PSD in the alpha band, as assessed before stimulus (word) onset. RESULTS: No statistically significant differences were noted among frontal theta power levels in the four test conditions. However, parietal alpha power levels were significantly higher in the "binaural noise" and in the "noise to worse hearing ear" conditions than in the "quiet" and "noise to better hearing ear" conditions (p < 0.001). SRT scores were consistent with task difficulty, but did not correlate with alpha and theta power level variations. CONCLUSION: This is the first time that EEG has been applied to children with sensorineural hearing loss with the purpose of studying the cognitive load during effortful listening. Significantly higher parietal alpha power levels in two of three noisy conditions, compared to the quiet condition, are consistent with increased cognitive load. Specifically, considering the time window of the analysis (pre-stimulus), parietal alpha power levels may be a measure of cognitive functions such as sustained attention and selective inhibition. In this respect, the significantly lower parietal alpha power levels in the most challenging listening condition (i.e. noise to the better ear) may be attributed to loss of attention and to the subsequent fatigue and "withdrawal" from the task at hand.
[Mh] Termos MeSH primário: Cognição/fisiologia
Eletroencefalografia/métodos
Perda Auditiva Bilateral/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Percepção Auditiva
Criança
Implante Coclear/métodos
Feminino
Audição
Auxiliares de Audição
Testes Auditivos/métodos
Seres Humanos
Masculino
Percepção da Fala/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


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[PMID]:28412992
[Au] Autor:Smith A; Gutteridge I; Elliott D; Cronin M
[Ad] Endereço:School of Medicine,Griffith University,Gold Coast,Queensland,Australia.
[Ti] Título:Acute otitis media associated bilateral sudden hearing loss: case report and literature review.
[So] Source:J Laryngol Otol;131(S2):S57-S61, 2017 Jul.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sudden sensorineural hearing loss is a rare otological condition with potential for dire outcomes including permanent hearing loss. Although the majority of cases are deemed idiopathic, bilateral sudden sensorineural hearing loss represents a rare subset typically related to systemic conditions, with higher morbidity and mortality. A controversial association with acute otitis media has been reported, with few bilateral cases published in the literature. CASE REPORT: A very rare case of bilateral sudden sensorineural hearing loss associated with acute otitis media is described, with a review of the literature. CONCLUSION: The limited evidence available suggests that acute otitis media with tinnitus and/or bacterial pathology may have an increased risk of sudden sensorineural hearing loss, which is consistent with the case described. Although there is no sufficiently powered published evidence to provide definitive treatment guidelines, the literature reviewed suggests that early myringotomy and antibiotics may greatly improve treatment outcomes.
[Mh] Termos MeSH primário: Perda Auditiva Bilateral/etiologia
Perda Auditiva Súbita/etiologia
Otite Média/complicações
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117000779



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