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  1 / 2006 MEDLINE  
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[PMID]:27779563
[Au] Autor:Liebau A; Pogorzelski O; Salt AN; Plontke SK
[Ad] Endereço:*Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany †Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri, U.S.A.
[Ti] Título:Hearing Changes After Intratympanically Applied Steroids for Primary Therapy of Sudden Hearing Loss: A Meta-analysis Using Mathematical Simulations of Drug Delivery Protocols.
[So] Source:Otol Neurotol;38(1):19-30, 2017 01.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Controlled and uncontrolled studies with primary intratympanic or combined intratympanic and systemic application of glucocorticosteroids for idiopathic sudden hearing loss were analyzed by means of a meta-analysis in an attempt to establish optimal local drug delivery protocols. STUDY DESIGN: A total of 25 studies with 28 treatment groups between January 2000 and June 2014 were selected that adequately described drug delivery protocols. Cochlear drug levels were calculated by a validated computer model of drug dispersion in the inner ear fluids based on the concentration and volume of glucocorticoids applied, the time the drug remained in the middle ear, and the specific timing of injections. Various factors were compared with hearing outcome, including baseline data, individual parameters of the application protocols, calculated peak concentration (Cmax), and total dose (area under the curve). RESULTS: There was no dependence of hearing outcome on individual parameters of the application protocol, Cmax, or area under the curve. Final hearing threshold was notably independent of delay of treatment. CONCLUSION: During primary intratympanic or combined steroid therapy of idiopathic sudden hearing loss, the tendency toward early treatment having a positive effect on hearing improvement is thought to be a "sham effect," likely related to spontaneous recovery. Change in pure-tone average may not be an adequate outcome parameter to assess effectiveness of the intervention, as it depends on the degree of initial hearing loss. Final pure-tone average provides a better alternative.
[Mh] Termos MeSH primário: Glucocorticoides/administração & dosagem
Perda Auditiva Súbita/tratamento farmacológico
[Mh] Termos MeSH secundário: Simulação por Computador
Audição/efeitos dos fármacos
Seres Humanos
Injeção Intratimpânica
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  2 / 2006 MEDLINE  
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[PMID]:29390288
[Au] Autor:Lai D; Zhao F; Jalal N; Zheng Y
[Ad] Endereço:Hearing Center/Hearing and Speech Science Laboratory, Department of Otolaryngology Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu.
[Ti] Título:Intratympanic glucocorticosteroid therapy for idiopathic sudden hearing loss: Meta-analysis of randomized controlled trials.
[So] Source:Medicine (Baltimore);96(50):e8955, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Glucocorticoids are the standard treatment for idiopathic sudden sensorineural hearing loss (ISSNHL), but whether intratympanic or systemic therapy is superior remains controversial. Previous meta-analyses of this question have omitted key clinical trials or included observational studies. METHODS: English-language randomized controlled trials in OvidSP, PubMed, Embase, CINAHL, and the Cochrane Library comparing intratympanic versus systemic glucocorticoid therapy for ISSNHL were meta-analyzed using RevMan 5.3. The primary outcome of interest was improvement in pure tone average (PTA) threshold. RESULTS: Six trials involving 248 patients receiving intratympanic steroids and 236 receiving systemic steroids were meta-analyzed. PTA thresholds were similar between the 2 groups at 3 months after therapy initiation (mean difference, 0.24; 95% confidence interval [CI] -2.43 to 2.91, P = .86; I = 54%, P = .07, random-effects model). PTA thresholds were also similar at 6 months (mean difference, 4.69, 95% CI -5.84 to 15.22, P = .38), although the results showed extremely high heterogeneity (I = 98%). Sensitivity analysis indicated that a single trial containing 250 patients provided the strongest evidence for equivalence between the 2 types of therapy. Rates of recovery within 3 months (defined as PTA improvement >10 dB) were similar between the 2 types of therapy (odds ratio 0.92, 95% CI 0.59-1.43, P = .70), with no significant heterogeneity in the pooled data (I = 1%, P = .40). CONCLUSION: Intratympanic and systemic steroids' therapies appear to show similar short-term efficacy for restoring hearing in patients with ISSNHL. Intratympanic therapy may reduce systemic side effects associated with steroid use.
[Mh] Termos MeSH primário: Glucocorticoides/uso terapêutico
Perda Auditiva Neurossensorial/tratamento farmacológico
Perda Auditiva Súbita/tratamento farmacológico
[Mh] Termos MeSH secundário: Seres Humanos
Injeção Intratimpânica
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008955


  3 / 2006 MEDLINE  
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[PMID]:29365372
[Au] Autor:Fang X; Yu LS; Ma X; Xia RM; Jiang YH; Liu HX; Jing YY
[Ad] Endereço:Department of Otorhinolaryngology, People's Hospital of Peking University, Beijing 100044, China (now working at Human Anatomy Teaching and Research Department of Health Science Center of Peking University).
[Ti] Título:[Correlation between the changes of fibrinogen and the treatment effect of all-frequency sudden deafness].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):3-8, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze the correlation between the changes of fibrinogen and the treatment effect of all-frequency sudden deafness, and to explore the individualized treatment strategy for the use of Batroxobin. Patients with all-frequency sudden deafness who were admitted to Department of Otorhinolaryngology, People's Hospital of Peking University, from January 2010 to September 2016 were selected. All patients were given standard treatment and regular use of Batroxobin. Value of fibrinogen on D1 (before treatment) / D3 / D7 (±1) and D14 (±2) were recorded, at the same time, the correlation between the changes of fibrinogen and prognosis of all-frequency sudden deafness by the audiograms of onset and after-treatment of all patients were analyzed. Independent -test was used to analyze normal distributed measurement data and chi square linear trend test was used to analyze the curative effect of different fibrinogen groups. A total of 148 patients were included, the outcomes were worst when the patient's fibrinogen was below 2 g/L or above 4 g/L before treatment, ineffective rate were both 50%. The fibrinogen was lowest when the treatment came to the third day. Normally, the patient's prognosis was best when this value waved between 0.7 and 0.9 g/L, with a total effective rate between 73.9% and 83.3%. The fibrinogen value of the 7th day was a good indicator of the outcome, and Fib7 value was significant lower in patients of effective group than ineffective ones ((1.25±0.37)g/L (1.38±0.35) g/L, =-0.27, =0.04). Patients found a best recovery when Fib7 was below 1 g/L, and the higher the Fib7 value, the higher the inefficiency (χ(2)=7.55, =0.01). Batroxobin showed safety during the treatment and found no complications. The change of fibrinogen in the process of all-frequency sudden deafness is closely related to the curative effect.
[Mh] Termos MeSH primário: Batroxobina/farmacologia
Fibrinogênio/efeitos dos fármacos
Fibrinolíticos/farmacologia
Perda Auditiva Súbita/sangue
Perda Auditiva Súbita/tratamento farmacológico
[Mh] Termos MeSH secundário: Distribuição de Qui-Quadrado
Fibrinogênio/análise
Testes Auditivos
Seres Humanos
Prognóstico
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fibrinolytic Agents); 9001-32-5 (Fibrinogen); EC 3.4.21.- (Batroxobin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.002


  4 / 2006 MEDLINE  
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[PMID]:29381991
[Au] Autor:Li Q; Peng X; Huang H; Li J; Wang F; Wang J
[Ti] Título:RNA sequencing uncovers the key microRNAs potentially contributing to sudden sensorineural hearing loss.
[So] Source:Medicine (Baltimore);96(47):e8837, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to identify miRNAs that may contribute to the pathogenesis of sudden sensorineural hearing loss (SSNHL) by RNA-seq (RNA-sequencing).RNA was extracted from SSNHL patients and healthy volunteers, respectively. Sequencing was performed on HiSeq4000 platform. After filtering, clean reads were mapped to the human reference genome hg19. Differential expression analysis of miRNAs between the SSNHL samples and the normal samples was performed using DEseq to identify differentially expressed microRNAs (DEMs). The target genes of the DEMs were predicted using the online tool miRWalk, which were then mapped to DAVID (https://david.ncifcrf.gov/) for functional annotation based on GO database and for pathway enrichment analysis based on KEGG. Finally, a miRNA-target-protein-protein interaction (PPIs) network was constructed using the DEMs and their target genes with interaction.Differential expression analysis reveals 24 DEMs between the SSNHL group and control group. A total of 1083 target genes were predicted. GO functional annotation analysis reveals that the target genes in the top 10 terms are mainly related to the development of salivary glands, neurotransmission, dendritic development, and other processes. KEGG pathway enrichment analysis reveals that the target genes were functionally enriched in pathways arachidonic acid metabolism, complement and coagulation cascades, linoleic acid metabolism, and MAPK signaling pathway. In the miRNA-target-PPI network, hsa-miR-34a/548n/15a/143/23a/210/1255a/18b/ /1180/99b had the most target genes; genes YWHAG, GSK3B, CDC42, NR3C1, LCK, UNC119, SIN3A, and NFKB2, interact with most other genes among all the predicted target genes.Hsa-miR-34a/15a/23a/210/18b/548n/143 is likely to have a role in the pathogenesis of SSNHL.
[Mh] Termos MeSH primário: Perda Auditiva Neurossensorial/genética
Perda Auditiva Súbita/genética
MicroRNAs/genética
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Análise de Sequência de RNA
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN34 microRNA, human); 0 (MicroRNAs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008837


  5 / 2006 MEDLINE  
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[PMID]:28467585
[Au] Autor:Kiliç E; Genç H; Aydin Ü; Asik B; Satar B
[Ad] Endereço:Department of Otolaryngology, Head and Neck Surgery, Gülhane Military Medicine Academy, Haydarpasa Training Hospital, Istanbul-Turkey. kilic_erbil@yahoo.com.
[Ti] Título:Variations in otological presentation of lightning strike victims: Clinical report of 3 patients.
[So] Source:Ulus Travma Acil Cerrahi Derg;23(2):163-166, 2017 Mar.
[Is] ISSN:1306-696X
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Lightning strike can cause fatal or nonfatal injuries. Some nonfatal injuries are associated with otological symptoms and findings. Conductive hearing loss due to rupture of the tympanic membrane is the most common audiovestibular lesion of lightning strike. Various forms of sensorineural hearing loss and dizziness have also been reported. Presently described are 3 cases of lightning strike injury. First patient had mid-frequency hearing loss in right ear and high frequency sensorineural hearing loss in left ear. Second patient had high frequency sensorineural hearing loss in left ear, and the third had peripheral facial palsy with perilymphatic fistula on same side. This is the first documented case of mid-frequency hearing loss occurring after lightning strike.
[Mh] Termos MeSH primário: Perda Auditiva Súbita
Lesões por Ação do Raio
[Mh] Termos MeSH secundário: Perda Auditiva Súbita/diagnóstico
Perda Auditiva Súbita/etiologia
Perda Auditiva Súbita/fisiopatologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.5505/tjtes.2016.88580


  6 / 2006 MEDLINE  
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[PMID]:29179790
[Au] Autor:Sagiv D; Migirov L; Madgar O; Nakache G; Wolf M; Shapira Y
[Ad] Endereço:Department of Otolaryngology - Head and Neck Surgery,Sheba Medical Center,Tel Hashomer,Israel.
[Ti] Título:Mobile phone usage does not affect sudden sensorineural hearing loss.
[So] Source:J Laryngol Otol;132(1):29-32, 2018 Jan.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Recent studies found that mobile phone users had a significantly greater risk of having elevated thresholds in speech frequencies. This study investigated the correlation between the laterality of sudden sensorineural hearing loss, handedness and the preferred ear for mobile phone use. METHODS: The study included all patients who presented with sudden sensorineural hearing loss to the Department of Otolaryngology - Head and Neck Surgery in our tertiary referral medical centre between 2014 and 2016. Patients were asked to indicate their dominant hand and preferred ear for mobile phone use. RESULTS: The study comprised 160 patients. No correlation was found between the dominant hand or preferred ear for mobile phone use and the side of sudden sensorineural hearing loss. There was no correlation between the side of the sudden sensorineural hearing loss (preferable or non-preferable for mobile phone use) and audiometric characteristics. CONCLUSION: No correlation was found between the laterality of ears used for mobile phone and sudden sensorineural hearing loss.
[Mh] Termos MeSH primário: Telefone Celular
Perda Auditiva Neurossensorial/etiologia
Perda Auditiva Súbita/etiologia
Audição/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Audiometria de Tons Puros
Feminino
Perda Auditiva Neurossensorial/fisiopatologia
Perda Auditiva Súbita/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117002365


  7 / 2006 MEDLINE  
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[PMID]:28885341
[Au] Autor:Sun Y; Guo Y; Wang H; Chen Z; Wu Y; Shi H; Feng Y; Yin S
[Ad] Endereço:Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Xuhui District, Shanghai, China.
[Ti] Título:Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study.
[So] Source:Medicine (Baltimore);96(36):e7877, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We explored possible relationships between sudden sensorineural hearing loss (SSNHL) in patients differing in terms of audiographic data and the levels of vascular markers in routine blood data.We included 37 patients with low-frequency SSNHL (LF-SSNHL), 28 with high-frequency SSNHL (HF-SSNHL), 32 with all-frequency SSNHL (AF-SSNHL), 32 with total-deafness SSNHL (TD-SSNHL), and 31 age- and sex-matched healthy controls. Peripheral venous blood samples were collected, and routine blood parameters including platelet and lymphocyte count, mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) were measured. Each group was divided into recovery subgroup and unrecovery subgroup in accordance with hearing level after 1 month therapy, then compared the difference of platelet and lymphocyte count, MPV, and PLR between the 2 subgroups.No significant difference was observed between platelet count of all SSNHL patients and control group (all P > .05). MPV of AF-SSNHL and TD-SSNHL, PLR of all SSNHL patients were significantly higher than those of control group (all P < .05), while lymphocyte count of all audiographically distinct SSNHL patients was significantly lower than that of control group (all P < .05). However, the difference of platelet count, lymphocyte count, MPV, and PLR among audiographically distinct SSNHL patients was not significant (all P > .05). In HF-SSNHL patients, lymphocyte count of unrecovery subgroup was significantly lower, while MPV and PLR of the unrecovery subgroup were significantly higher than those of recovery subgroup (all P < .05). In AF-SSNHL patients, MPV of the unrecovery group was significantly higher than that of recovery subgroup (P < .05).Lymphocyte count, MPV, and PLR may be relative to SSSNHL, but they could not be used to distinct SSNHL audiographically. Lower lymphocyte, higher MPV, and PLR may be indicative for the prognosis of HF-SSNHL patients; higher MPV may be related to bad treatment outcome of AF-SSNHL patients.
[Mh] Termos MeSH primário: Perda Auditiva Neurossensorial/sangue
Perda Auditiva Súbita/sangue
[Mh] Termos MeSH secundário: Adulto
Audiometria de Tons Puros
Biomarcadores/sangue
Feminino
Perda Auditiva Neurossensorial/terapia
Perda Auditiva Súbita/terapia
Seres Humanos
Contagem de Linfócitos
Masculino
Volume Plaquetário Médio
Meia-Idade
Prognóstico
Estudos Retrospectivos
Limiar Sensorial
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007877


  8 / 2006 MEDLINE  
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[PMID]:28818308
[Au] Autor:Düzenli U; Bozan N; Ayral A; Yalinkiliç A; Kiroglu AF
[Ad] Endereço:Yüzüncü Yil University, Faculty of Medicine, Department of Otorhinolaryngology, Van, Turkey. Electronic address: ufukduzenli@yyu.edu.tr.
[Ti] Título:A honey bee can threat ear: Sudden sensorineural hearing loss.
[So] Source:Am J Emerg Med;35(11):1788.e1-1788.e3, 2017 Nov.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sudden sensorineural hearing loss is an otologic emergency. Many etiological factors can lead to this pathology. Honey bee (Apis mellifera) sting may lead to local and systemic reactions due to sensitization of the patient. In this paper we described a sudden sensorineural hearing loss occurred after honey bee sting.
[Mh] Termos MeSH primário: Perda Auditiva Súbita/etiologia
Hipersensibilidade/etiologia
Mordeduras e Picadas de Insetos/complicações
[Mh] Termos MeSH secundário: Betametasona/uso terapêutico
Dexametasona/uso terapêutico
Dispneia/etiologia
Glucocorticoides/uso terapêutico
Perda Auditiva Súbita/tratamento farmacológico
Perda Auditiva Súbita/fisiopatologia
Testes Auditivos
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Hipersensibilidade/tratamento farmacológico
Injeção Intratimpânica
Mordeduras e Picadas de Insetos/tratamento farmacológico
Masculino
Metilprednisolona/uso terapêutico
Náusea/etiologia
Feniramina/uso terapêutico
Zumbido/etiologia
Vômito/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Histamine H1 Antagonists); 134FM9ZZ6M (Pheniramine); 7S5I7G3JQL (Dexamethasone); 9842X06Q6M (Betamethasone); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


  9 / 2006 MEDLINE  
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[PMID]:28807070
[Au] Autor:Haremza C; Klopp-Dutote N; Strunski V; Page C
[Ad] Endereço:ENT and Head and Neck Surgery Department,Amiens University Hospital,France.
[Ti] Título:Evaluation of cardiovascular risks and recovery of idiopathic sudden sensorineural hearing loss in hospitalised patients: comparison between complete and partial sudden sensorineural hearing loss.
[So] Source:J Laryngol Otol;131(10):919-924, 2017 Oct.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the presence of cardiovascular risk factors and recovery of idiopathic sudden sensorineural hearing loss in hospitalised patients. METHODS: A single-centre retrospective study of 80 patients hospitalised for idiopathic sudden sensorineural hearing loss was conducted over a 6-year period. Mean pure tone hearing thresholds were assessed by pure tone audiometry. RESULTS: Twenty-three of 80 patients (28.75 per cent) initially had no cardiovascular risk factors. Forty-five patients had hyperlipidaemia, 22 patients had hypertension, 7 patients had diabetes mellitus and 7 patients were obese. No statistically significant difference was observed between patients with complete versus partial sudden sensorineural hearing loss (p = 0.0708) concerning the cardiovascular risk factors. At long-term follow up, the hearing recovery rate was not significantly different between the two groups of patients (p = 0.7541). CONCLUSION: The lack of a clear relationship between idiopathic sudden sensorineural hearing loss and cardiovascular risk factors suggests that sudden sensorineural hearing loss has a predominantly multifactorial disease profile regardless of hearing impairment severity.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Perda Auditiva Neurossensorial/diagnóstico
Perda Auditiva Súbita/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Audiometria de Tons Puros
Feminino
Perda Auditiva Neurossensorial/complicações
Perda Auditiva Súbita/complicações
Hospitalização
Seres Humanos
Masculino
Meia-Idade
Recuperação de Função Fisiológica
Estudos Retrospectivos
Fatores de Risco
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001736


  10 / 2006 MEDLINE  
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[PMID]:28719039
[Au] Autor:Choo OS; Yang SM; Park HY; Lee JB; Jang JH; Choi SJ; Choung YH
[Ad] Endereço:Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
[Ti] Título:Differences in clinical characteristics and prognosis of sudden low- and high-frequency hearing loss.
[So] Source:Laryngoscope;127(8):1878-1884, 2017 Aug.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: We compared the clinical characteristics between acute low- and high-frequency hearing loss (LF and HF, respectively) patients, and the efficacy of three different treatment protocols (systemic steroids, intratympanic steroid injection, and combination therapy). STUDY DESIGN: Prospective, randomized controlled study. METHODS: A total of 111 patients diagnosed with LF or HF were treated on an outpatient basis. Each group was randomly divided into three equal subgroups based on therapy: oral steroid, intratympanic dexamethasone injection (IT), and combination therapy. Hearing gain was estimated by comparing pre- and post-treatment pure-tone averages. Recovery rate was assessed by Clinical Practice Guideline: Sudden Hearing Loss from the American Academy of Otolaryngology-Head and Neck Surgery. RESULTS: In comparison of chief complaints, ear fullness and hearing loss were more common in the LF and HF group, respectively (P = .033 and P = .001, respectively). Hearing recovery rates were significantly different between the two groups (i.e., 74.1% [40/54] in the LF group and 45.6% [26/57] in the HF group; P < .001). Oral steroid therapy was most effective in the LF group (P = .017). In the HF group, all three modalities showed similar results, although IT tended to be the most effective (P = .390). CONCLUSIONS: There were differences in chief complaints and treatment responses between LF and HF patients. Although they showed similar partial damage in the cochlea, the pathophysiology of LF and HF may be quite different. LEVEL OF EVIDENCE: 1b. Laryngoscope, 127:1878-1884, 2017.
[Mh] Termos MeSH primário: Perda Auditiva de Alta Frequência/diagnóstico
Perda Auditiva de Alta Frequência/tratamento farmacológico
Perda Auditiva Neurossensorial/diagnóstico
Perda Auditiva Neurossensorial/tratamento farmacológico
Perda Auditiva Súbita/diagnóstico
Perda Auditiva Súbita/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Protocolos Clínicos
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26382



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