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[PMID]:29256428
[Au] Autor:Morell M; Lehnert K; IJsseldijk LL; Raverty SA; Wohlsein P; Gröne A; André M; Siebert U; Shadwick RE
[Ad] Endereço:Zoology Department, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada.
[Ti] Título:Parasites in the inner ear of harbour porpoise: cases from the North and Baltic Seas.
[So] Source:Dis Aquat Organ;127(1):57-63, 2017 Dec 19.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Peribullar sinuses of harbour porpoises Phocoena phocoena are parasitized with high prevalence by the nematode Stenurus minor. The effect of S. minor on the hearing ability of this species is still undetermined. Here, we review the occurrence of S. minor in the inner ear of harbour porpoises recovered from strandings in the North and Baltic Seas. In particular, we present the results from ears collected in German and Danish waters from 2002 to 2016 and from Dutch waters from 2010 to 2016. While the prevalence of S. minor in pterygoid and peribullar sinuses and tympanic cavity was high in harbour porpoises (66.67% in our cases), its prevalence in the cochlea was rare. Only 1 case out of 129 analysed by either histology, electron microscopy or immunofluorescence showed the presence of a nematode parasite morphologically consistent with S. minor at the most basal portion of the right cochlea. This individual also had severe haemorrhage along the right cochlear spiral, which was likely caused by ectopic S. minor migration. Although this animal might have had impaired hearing in the right ear, it was otherwise in good body condition with evidence of recent feeding. These findings highlight the need to study the effect of parasites on hearing, and other pathological changes that might impair appropriate processing of acoustic information.
[Mh] Termos MeSH primário: Doenças do Labirinto/veterinária
Infecções por Nematoides/veterinária
Phocoena/parasitologia
[Mh] Termos MeSH secundário: Animais
Orelha Interna/parasitologia
Orelha Interna/ultraestrutura
Doenças do Labirinto/epidemiologia
Doenças do Labirinto/parasitologia
Nematoides/classificação
Nematoides/isolamento & purificação
Infecções por Nematoides/epidemiologia
Infecções por Nematoides/parasitologia
Mar do Norte/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.3354/dao03178


  2 / 4177 MEDLINE  
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[PMID]:29224758
[Au] Autor:Kerr R; Kang E; Hopkins B; Anne S
[Ad] Endereço:Department of Otolaryngology, Head and Neck Surgery, The Cleveland Clinic, Cleveland, OH, USA.
[Ti] Título:Pediatric tinnitus: Incidence of imaging anomalies and the impact of hearing loss.
[So] Source:Int J Pediatr Otorhinolaryngol;103:147-149, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Guidelines exist for evaluation and management of tinnitus in adults; however lack of evidence in children limits applicability of these guidelines to pediatric patients. Objective of this study is to determine the incidence of inner ear anomalies detected on imaging studies within the pediatric population with tinnitus and evaluate if presence of hearing loss increases the rate of detection of anomalies in comparison to normal hearing patients. METHODS: Retrospective review of all children with diagnosis of tinnitus from 2010 to 2015 ;at a tertiary care academic center. RESULTS: 102 pediatric patients with tinnitus were identified. Overall, 53 patients had imaging studies with 6 abnormal findings (11.3%). 51/102 patients had hearing loss of which 33 had imaging studies demonstrating 6 inner ear anomalies detected. This is an incidence of 18.2% for inner ear anomalies identified in patients with hearing loss (95% confidence interval (CI) of 7.0-35.5%). 4 of these 6 inner ear anomalies detected were vestibular aqueduct abnormalities. The other two anomalies were cochlear hypoplasia and bilateral semicircular canal dysmorphism. 51 patients had no hearing loss and of these patients, 20 had imaging studies with no inner ear abnormalities detected. There was no statistical difference in incidence of abnormal imaging findings in patients with and without hearing loss (Fisher's exact test, p ;= ;0.072.) CONCLUSION: There is a high incidence of anomalies detected in imaging studies done in pediatric patients with tinnitus, especially in the presence of hearing loss.
[Mh] Termos MeSH primário: Orelha Interna/anormalidades
Perda Auditiva/etiologia
Doenças do Labirinto/epidemiologia
Zumbido/complicações
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Orelha Interna/diagnóstico por imagem
Feminino
Testes Auditivos
Seres Humanos
Incidência
Doenças do Labirinto/complicações
Doenças do Labirinto/diagnóstico por imagem
Masculino
Estudos Retrospectivos
Centros de Atenção Terciária
Zumbido/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28834895
[Au] Autor:Im DH; Yang YS; Choi H; Choi S; Shin JE; Kim CH
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
[Ti] Título:Pseudo-spontaneous nystagmus in horizontal semicircular canal canalolithiasis.
[So] Source:Medicine (Baltimore);96(34):e7849, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Benign paroxysmal positional vertigo (BPPV) involving horizontal semicircular canal (HSCC) is characterized by direction-changing positional nystagmus (DCPN) in a supine roll test, and the occurrence of spontaneous nystagmus in HSCC BPPV has been reported recently. The aim of this study is to investigate the characteristics of pseudo-spontaneous nystagmus (PSN) in patients with HSCC canalolithiasis, and evaluate the effect of the presence of PSN on treatment outcome.Between April 2014 and January 2016, 75 and 59 patients with HSCC canalolithiasis and cupulolithiasis, respectively, were enrolled. Spontaneous and positional nystagmus were examined.PSN was observed in 31 of 75 patients (41%) with HSCC canalolithiasis, and 55 of 59 patients (93%) with HSCC cupulolithiasis. PSN persisted during the period of observation, which was at least 1 minute in all patients with PSN. In HSCC canalolithiasis, direction-reversing nystagmus was observed in 58 patients (25 bilateral and 33 unilateral). Nine of 25 patients with bilateral direction-reversing nystagmus, and 22 of 33 patients with unilateral direction-reversing nystagmus showed PSN. None of 17 patients without direction-reversing nystagmus showed PSN. The direction of PSN corresponded to that of direction-reversing nystagmus in all 22 patients with unilateral direction-reversing nystagmus. The proportion of patients who recovered after 1 session of repositioning maneuver was not significantly different between patients with and without PSN (P = .867).PSN was observed more commonly in HSCC cupulolithiasis than canalolithiasis. The pathophysiologic mechanism underlying PSN can be explained by natural inclination of HSCC and medial to lateral orientation of the HSCC cupular axis in cupulolithiasis, and by spontaneous reversal of initial positional nystagmus (direction-reversing nystagmus) generated by short-term adaptation of vestibulo-ocular reflex in canalolithiasis. The presence of PSN in HSCC canalolithiasis may not affect the treatment outcome.
[Mh] Termos MeSH primário: Doenças do Labirinto/epidemiologia
Litíase/epidemiologia
Nistagmo Patológico/epidemiologia
Canais Semicirculares/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Vertigem Posicional Paroxística Benigna/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Posicionamento do Paciente
Testes de Função Vestibular
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007849


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[PMID]:28653553
[Au] Autor:Xie Y; Sharon JD; Pross SE; Abt NB; Varma S; Della Santina CC; Minor LB; Carey JP
[Ad] Endereço:1 Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
[Ti] Título:Surgical Complications from Superior Canal Dehiscence Syndrome Repair: Two Decades of Experience.
[So] Source:Otolaryngol Head Neck Surg;157(2):273-280, 2017 Aug.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective To determine the incidence of surgical complications associated with superior canal dehiscence syndrome (SCDS) repair and identify the demographic, medical, and intraoperative risk factors that are associated with SCDS complications. Study Design Cases series with chart review, including patients who underwent SCDS repair between 1996 and 2015. Setting A tertiary care academic medical center. Subjects and Methods Data were collected from 220 patients, including demographic information, medical comorbidities, prior otologic surgical history, surgical approach, intraoperative findings, and postoperative complications. Relative risk analysis and multivariable logistic regression evaluated the associations between perioperative risk factors and SCDS complications. Results A total of 242 consecutive cases were performed: 95.5% middle fossa and 4.5% transmastoid approach (mean age: 47.8 ± 10.6 years; 54.5% female). Surgical complications were reported in 27 (11.2%) cases; 20 (8.3%) had Clavien-Dindo grade I complications, most commonly benign paroxysmal positional vertigo (n = 11, 4.5%) and profound sensorineural hearing loss (n = 6, 2.5%). Two cases (0.8%) had grade II; 4 cases (1.7%), grade III; and 1 case (0.4%), grade IV complications. In the analysis of comorbidities, only preoperative coagulopathy was significantly associated with increased risk of complications (relative risk = 6.4, P < .01). Following multivariate logistic regression adjusting for demographic covariates, coagulopathy was still associated with increased odds of complications (odds ratio = 15.7, P = .03). There were no significant associations between other risk factors and complications. Conclusion SCDS repair has low rates of adverse events. We observed an incidence of 11.2% complications, most commonly postoperative benign paroxysmal positional vertigo. The risk of nonotologic intracranial complications (1.7%) is low.
[Mh] Termos MeSH primário: Doenças do Labirinto/cirurgia
Procedimentos Cirúrgicos Otológicos/efeitos adversos
Complicações Pós-Operatórias/epidemiologia
Canais Semicirculares/cirurgia
[Mh] Termos MeSH secundário: Centros Médicos Acadêmicos
Adulto
Vertigem Posicional Paroxística Benigna/etiologia
Feminino
Seres Humanos
Incidência
Modelos Logísticos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Otológicos/métodos
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817706491


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[PMID]:28576532
[Au] Autor:Halle TR; Soares BP; Todd NW
[Ad] Endereço:Department of Otolaryngology-Head & Neck Surgery, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA, 30322, USA.
[Ti] Título:Inner ear anomalies in children with isolated unilateral congenital aural atresia.
[So] Source:Int J Pediatr Otorhinolaryngol;95:5-8, 2017 Apr.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: We aim to define the frequencies of anomalies of the inner ear, oval window, and round window ipsilateral to isolated non-syndromic unilateral aural atresia. METHODS AND MATERIALS: Retrospective case series. We reviewed high resolution computed tomography scans of the temporal bones of 70 children with isolated non-syndromic unilateral congenital aural atresia. Scans were reviewed according to the Jahrsdoerfer criteria and further evaluated for anomalies of the vestibule, semi-circular canals, cochlea, internal auditory canal and vestibulocochlear nerve. RESULTS: Inner ear dysplasia was seen in two of 70 atretic ears: one with a dysmorphic lateral semicircular canal and another with a large vestibule assimilating the lateral semicircular canal. Abnormalities of the oval window and round window ipsilateral to the atresia were identified in 21% (15) and 7% (5), respectively, of the atretic ears. Oval window and round window abnormalities were associated with disproportionately lower Jahrsdoerfer scores compared to aural atresia patients without these abnormalities (P < 0.001 and P = 0.04, respectively). CONCLUSION: Compared to studies that included syndromic or bilateral atresia cases, we found inner ear and oval window abnormalities less common in children with isolated non-syndromic unilateral aural atresia. However, round window anomalies seem to occur at about the same frequency.
[Mh] Termos MeSH primário: Anormalidades Congênitas/epidemiologia
Orelha Interna/anormalidades
Orelha/anormalidades
Doenças do Labirinto/epidemiologia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Orelha Interna/diagnóstico por imagem
Feminino
Seres Humanos
Lactente
Doenças do Labirinto/complicações
Doenças do Labirinto/diagnóstico por imagem
Masculino
Estudos Retrospectivos
Osso Temporal/anormalidades
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28548616
[Au] Autor:Lagman C; Ong V; Chung LK; Elhajjmoussa L; Fong C; Wang AC; Gopen Q; Yang I
[Ad] Endereço:Departments of 1 Neurosurgery.
[Ti] Título:Pediatric superior semicircular canal dehiscence: illustrative case and systematic review.
[So] Source:J Neurosurg Pediatr;20(2):196-203, 2017 Aug.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE The purpose of this study is to present an illustrative case of pediatric superior semicircular canal dehiscence (SSCD) and to systematically review the current published literature in the pediatric population. METHODS An electronic search of the Scopus, Web of Science, PsycINFO, Cochrane, and Embase databases was performed by 2 independent authors through January 2017. Search term combinations included "pediatrics," "children," "canal," and "dehiscence." Inclusion criteria were as follows: English, full-text clinical studies, case reports, and case series describing pediatric patient(s) (younger than 18 years) with CT evidence of SSCD. Baseline patient demographic characteristics, clinical presentations, dehiscence characteristics, management strategies, and outcome data were extracted. RESULTS A total of 14 studies involving 122 patients were included in the quantitative synthesis. The patients' mean age was 7.22 years. Male predominance was observed (approximate male-to-female ratio of 1.65:1). Neurodevelopmental disorders were common (n = 14, 11.5%). Auditory signs and symptoms were more common than vestibular signs and symptoms. Hearing loss (n = 62, 50.8%) was the most common auditory symptom and an indicator for imaging evaluation. Vertigo was the most common vestibular symptom (n = 8, 6.6%). Hearing aids were recommended in 8 cases (6.6%), and surgical repair was performed in 1 case (0.8%). Symptom outcomes and follow-up durations were infrequently reported. CONCLUSIONS The authors' data suggest that in pediatric SSCD, males are more commonly affected than females. This is different than the adult population in which females are predominantly affected. A history of otologic and/or neurodevelopmental abnormalities was common. There was a preponderance of auditory symptoms in this age group. Conservative management was favored in the majority.
[Mh] Termos MeSH primário: Doenças do Labirinto/diagnóstico
Canais Semicirculares
Base do Crânio/anormalidades
[Mh] Termos MeSH secundário: Pré-Escolar
Perda Auditiva Neurossensorial/etiologia
Seres Humanos
Doenças do Labirinto/complicações
Doenças do Labirinto/epidemiologia
Doenças do Labirinto/fisiopatologia
Masculino
Canais Semicirculares/fisiopatologia
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.3171/2017.3.PEDS1734


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[PMID]:28532527
[Au] Autor:Yamauchi D; Hara Y; Hidaka H; Kawase T; Katori Y
[Ad] Endereço:Department of Otolaryngology - Head and Neck Surgery,Tohoku University Graduate School of Medicine,Sendai,Miyagi,Japan.
[Ti] Título:How I do it: underwater endoscopic ear surgery for plugging in superior canal dehiscence syndrome.
[So] Source:J Laryngol Otol;131(8):745-748, 2017 Aug.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Underwater endoscopic ear surgery does not require suction and so protects the inner ear from unexpected aeration that may damage its function in the treatment of labyrinthine fistula. A method of underwater endoscopic ear surgery is proposed for the treatment of superior canal dehiscence. METHODS: Underwater endoscopic ear surgery was performed for plugging of the superior semicircular canal through the transmastoid approach. Saline solution was infused into the mastoid cavity through an Endo-Scrub Lens Cleaning Sheath. The tip of the inserted endoscope was filled completely with saline water. RESULTS: Using this underwater endoscopic view, the canal was clearly dissected to expose the semicircular canal membranous labyrinth and dehiscence area. No particular complication occurred during the surgical procedure. CONCLUSION: The underwater endoscopic ear surgery technique for plugging in superior canal dehiscence secures an excellent visual field and protects the inner ear from unexpected aeration.
[Mh] Termos MeSH primário: Endoscopia/métodos
Doenças do Labirinto/cirurgia
Procedimentos Cirúrgicos Otológicos/métodos
Canais Semicirculares/cirurgia
Cloreto de Sódio/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Síndrome
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001104


  8 / 4177 MEDLINE  
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[PMID]:28502274
[Au] Autor:Schneiders SMD; Rainsbury JW; Hensen EF; Irving RM
[Ad] Endereço:Department of ENT Surgery,Queen Elizabeth Hospital,Birmingham,UK.
[Ti] Título:Superior petrosal sinus causing superior canal dehiscence syndrome.
[So] Source:J Laryngol Otol;131(7):593-597, 2017 Jul.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine signs and symptoms for superior canal dehiscence syndrome caused by the superior petrosal sinus. METHODS: A review of the English-language literature on PubMed and Embase databases was conducted, in addition to a multi-centre case series report. RESULTS: The most common symptoms of 17 patients with superior petrosal sinus related superior canal dehiscence syndrome were: hearing loss (53 per cent), aural fullness (47 per cent), pulsatile tinnitus (41 per cent) and pressure-induced vertigo (41 per cent). The diagnosis was made by demonstration of the characteristic bony groove of the superior petrosal sinus and the 'cookie bite' out of the superior semicircular canal on computed tomography imaging. CONCLUSION: Pulsatile tinnitus, hearing loss, aural fullness and pressure-induced vertigo are the most common symptoms in superior petrosal sinus related superior canal dehiscence syndrome. Compared to superior canal dehiscence syndrome caused by the more common apical location of the dehiscence, pulsatile tinnitus and exercise-induced vertigo are more frequent, while sound-induced vertigo and autophony are less frequent. There is, however, considerable overlap between the two subtypes. The distinction cannot as yet be made on clinical signs and symptoms alone, and requires careful analysis of computed tomography imaging.
[Mh] Termos MeSH primário: Seio Cavernoso
Doenças do Labirinto/diagnóstico
Doenças do Labirinto/etiologia
Canais Semicirculares
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Aumento da Imagem
Interpretação de Imagem Assistida por Computador
Masculino
Doença de Meniere/diagnóstico
Doença de Meniere/etiologia
Meia-Idade
Equilíbrio Postural/fisiologia
Transtornos das Sensações/diagnóstico
Transtornos das Sensações/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001013


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[PMID]:28436246
[Au] Autor:Kaya S; Paparella MM; Cureoglu S
[Ad] Endereço:1 Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
[Ti] Título:Histopathologic Changes of Human Vestibular Epithelia in Intralabyrinthine Hemorrhage.
[So] Source:Ann Otol Rhinol Laryngol;126(6):445-450, 2017 Jun.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether intralabyrinthine hemorrhage affects vestibular hair cells, dark cells, and transitional cells in human temporal bones. METHODS: We examined 9 temporal bone specimens from 9 deceased donors with unilateral intralabyrinthine hemorrhage (the hemorrhage group) along with their 9 contralateral temporal bone specimens without hemorrhage (the control group). We estimated the density of type I and type II hair cells in all peripheral sensorial organs (including the cristae of the superior, lateral, and posterior semicircular canals, as well as the maculae of the saccule and utricle). We also estimated the density of dark and transitional cells in the lateral and posterior semicircular canals. RESULTS: The loss of type I hair cells in the cristae of the superior, lateral, and posterior semicircular canals and in the maculae of the saccule and utricle was significantly higher in the hemorrhage group, as compared with the control group ( P < .05). The density of type II hair cells in the cristae of the superior and posterior canals and in the macula of the saccule significantly differed between the hemorrhage group and the control group ( P < .05). CONCLUSION: The loss of vestibular hair cells might be the cause of vestibular symptoms in patients with intralabyrinthine hemorrhage.
[Mh] Termos MeSH primário: Células Epiteliais/patologia
Células Ciliadas Vestibulares/patologia
Hemorragia/patologia
Doenças do Labirinto/patologia
Osso Temporal/patologia
Vestíbulo do Labirinto/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Fotomicrografia
Canais Semicirculares/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417700646


  10 / 4177 MEDLINE  
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[PMID]:28384775
[Au] Autor:Heidenreich KD; Kileny PR; Ahmed S; El-Kashlan HK; Melendez TL; Basura GJ; Lesperance MM
[Ad] Endereço:Division of Otology-Neurotology, Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System, Ann Arbor.
[Ti] Título:Superior Canal Dehiscence Syndrome Affecting 3 Families.
[So] Source:JAMA Otolaryngol Head Neck Surg;143(7):656-662, 2017 Jul 01.
[Is] ISSN:2168-619X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Superior canal dehiscence syndrome (SCDS) is an increasingly recognized cause of hearing loss and vestibular symptoms, but the etiology of this condition remains unknown. Objective: To describe 7 cases of SCDS across 3 families. Design, Setting, and Participants: This retrospective case series included 7 patients from 3 different families treated at a neurotology clinic at a tertiary academic medical center from 2010 to 2014. Patients were referred by other otolaryngologists or were self-referred. Each patient demonstrated unilateral or bilateral SCDS or near dehiscence. Interventions: Clinical evaluation involved body mass index calculation, audiometry, cervical vestibular evoked myogenic potential testing, electrocochleography, and multiplanar computed tomographic (CT) scan of the temporal bones. Zygosity testing was performed on twin siblings. Main Outcomes and Measures: The diagnosis of SCDS was made if bone was absent over the superior semicircular canal on 2 consecutive CT images, in addition to 1 physiologic sign consistent with labyrinthine dehiscence. Near dehiscence was defined as absent bone on only 1 CT image but with symptoms and at least 1 physiologic sign of labyrinthine dehiscence. Results: A total of 7 patients (5 female and 2 male; age range, 8-49 years) from 3 families underwent evaluation. Family A consisted of 3 adult first-degree relatives, of whom 2 were diagnosed with SCDS and 1 with near dehiscence. Family B included a mother and her child, both of whom were diagnosed with unilateral SCDS. Family C consisted of adult monozygotic twins, each of whom was diagnosed with unilateral SCDS. For all cases, dehiscence was located at the arcuate eminence. Obesity alone did not explain the occurrence of SCDS because 5 of the 7 cases had a body mass index (calculated as weight in kilograms divided by height in meters squared) less than 30.0. Conclusions and Relevance: Superior canal dehiscence syndrome is a rare, often unrecognized condition. This report of 3 multiplex families with SCDS provides evidence in support of a potential genetic contribution to the etiology. Symptomatic first-degree relatives of patients diagnosed with SCDS should be offered evaluation to improve detection of this disorder.
[Mh] Termos MeSH primário: Doenças do Labirinto/diagnóstico
Doenças do Labirinto/genética
Canais Semicirculares/anormalidades
Osso Temporal/anormalidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Audiometria de Resposta Evocada
Índice de Massa Corporal
Criança
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Síndrome
Tomografia Computadorizada por Raios X
Potenciais Evocados Miogênicos Vestibulares
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1001/jamaoto.2016.4743



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