Base de dados : MEDLINE
Pesquisa : C09.218.568.120 [Categoria DeCS]
Referências encontradas : 734 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 74 ir para página                         

  1 / 734 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28687817
[Au] Autor:Lin PH; Hsu CJ; Lin YH; Lin YH; Lee HY; Wu CC; Liu TC
[Ad] Endereço:Department of Otolaryngology, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
[Ti] Título:Etiologic and Audiologic Characteristics of Patients With Pediatric-Onset Unilateral and Asymmetric Sensorineural Hearing Loss.
[So] Source:JAMA Otolaryngol Head Neck Surg;143(9):912-919, 2017 Sep 01.
[Is] ISSN:2168-619X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Pediatric-onset unilateral and asymmetric sensorineural hearing loss (SNHL) is a common condition, but in most patients, the cause remains unclear; thus, determination of the hearing outlook is difficult. Objective: To analyze the etiologic and audiologic characteristics of pediatric-onset unilateral and asymmetric SNHL. Design, Setting, and Participants: In this retrospective cohort study performed from January 1, 2008, through December 31, 2016, patients at a tertiary referral center who were diagnosed with pediatric-onset unilateral or asymmetric SNHL were divided into 3 groups according to their hearing levels: unilateral hearing loss with scaled-out levels (UHL-SO), unilateral hearing loss with residual hearing (UHL-RH), and asymmetric hearing loss (AHL). Main Outcomes and Measures: Basic demographic data, family and medical histories, audiologic results, imaging findings, and genetic results were ascertained and compared among patients of the 3 groups. Results: A total of 133 patients (mean [SD] age, 9.1 [10.9] years; 63 [47.4%] male and 70 [52.6%] female), including 50 with UHL-SO, 42 with UHL-RH, and 41 with AHL, were enrolled for analyses. Of 50 patients with UHL-SO, 49 (98.0%) had stable hearing levels with time, whereas 10 of 42 patients with UHL-RH (23.8%) and 18 of 41 patients with AHL (43.9%) revealed progressive or fluctuating hearing loss. Inner ear malformations detected with temporal bone high-resolution computed tomography, particularly cochlear aperture stenosis, were detected at higher rates in patients with UHL-SO (9 of 31 [29.0%]) and UHL-RH (6 of 24 [25.0%]) than in those with AHL (1 of 30 [3.3%]). In contrast, screening for mutations in 3 common deafness genes-GJB2, SLC26A4, and MTRNR1-achieved definite diagnosis in a higher percentage of patients with AHL (10 of 37 [27.0%]) than patients with UHL-SO (0 of 33) and UHL-RH (1 of 25 [4.0%]). Conclusions and Relevance: The UHL-SO and UHL-RH conditions share a common or similar etiopathogenesis different from that of AHL. Imaging studies and genetic testing might be prioritized during the respective general etiologic workups for patients with UHL and AHL. Regular hearing checkups are warranted for patients with UHL and AHL because a certain proportion of patients might sustain progression in SNHL.
[Mh] Termos MeSH primário: Perda Auditiva Neurossensorial/etiologia
Perda Auditiva Unilateral/etiologia
[Mh] Termos MeSH secundário: Criança
Doenças Cocleares/diagnóstico por imagem
Estudos de Coortes
Conexinas/genética
Constrição Patológica/diagnóstico por imagem
Orelha Interna/anormalidades
Orelha Interna/diagnóstico por imagem
Feminino
Testes Genéticos
Seres Humanos
Masculino
Proteínas de Membrana Transportadoras/genética
Mutação
Estudos Retrospectivos
Osso Temporal/diagnóstico por imagem
Doenças do Nervo Vestibulococlear/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexins); 0 (DFNA3 protein, human); 0 (Membrane Transport Proteins); 0 (SLC26A4 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE
[do] DOI:10.1001/jamaoto.2017.0945


  2 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28578713
[Au] Autor:Low WK; Xu S
[Ad] Endereço:Department of Otolaryngology,Singapore General Hospital,Singapore.
[Ti] Título:Delayed-onset haematoma formation after cochlear implantation.
[So] Source:J Laryngol Otol;131(8):684-687, 2017 Aug.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This paper presents our experience on delayed-onset haematoma formation after cochlear implantation, a topic which has not been well discussed in the literature. METHOD: Retrospective case review study. RESULTS: Five children who had undergone cochlear implant surgery at 1.5 to 4 years of age (median, 2.5 years) were studied. The haematoma episodes occurred 2-12 years (median, 6 years) after cochlear implantation. Two patients had recurrent episodes. Two of the seven haematoma episodes were managed by needle aspiration alone, four by incision and drainage alone, and one by both needle aspiration and incision and drainage. Other than one patient with coagulopathy, there were no obvious predisposing factors, including trauma. CONCLUSION: The majority of delayed-onset haematomas occurred without obvious predisposing factors. Needle aspiration can differentiate a haematoma from an abscess or cerebrospinal fluid leakage, and it provides an effective immediate therapeutic solution. However, aseptic techniques are emphasised to minimise the chances of an uncomplicated haematoma converting into a septic one.
[Mh] Termos MeSH primário: Doenças Cocleares/etiologia
Implante Coclear/efeitos adversos
Implantes Cocleares/efeitos adversos
Hematoma/etiologia
Hemorragia Pós-Operatória/etiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Doenças Cocleares/cirurgia
Drenagem/métodos
Feminino
Hematoma/cirurgia
Seres Humanos
Lactente
Masculino
Paracentese/métodos
Hemorragia Pós-Operatória/cirurgia
Estudos Retrospectivos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001165


  3 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28390604
[Au] Autor:Dogan M; Polat H; Yasar M; Bayram A; Karatas D; Hira I; Kale A; Senel F; Özcan I
[Ad] Endereço:Kayseri Training and Research Hospital ENT Department, Kayseri, Turkey.
[Ti] Título:Protective role of misoprostol in prevention of gentamicin ototoxicity.
[So] Source:Int J Pediatr Otorhinolaryngol;96:140-144, 2017 May.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To demonstrate potential protective effect of misoprostol on cochlear toxicity caused by gentamicin with electrophysiological tests and histopathological studies. MATERIALS AND METHODS: The study included 80 ears of 40 rats with normal hearing threshold and DPOAE value in both ears. Animals were assigned into 4 groups. The rats were randomized into 4 groups. Group I (n = 10): Gentamicin, Group II (n = 10): Gentamicin plus misoprostol, Group III (n = 10): Saline; Group IV (n = 10): Misoprostol. All drugs used in the study were given once daily for 15 days. DPOAE and ABR measurements were repeated after drug administration. Subsequently, the rats' cochleae were examined histopathologically. Baseline DPOAE and ABR values were compared to those obtained after drug exposure and cochlear toxicity was evaluated in electrophysiological manner. RESULTS: When At baseline, there were no significant differences in DPOAE responses at frequencies of 1001, 1501, 2002, 3003, 4004, 6006 and 7996 Hz among groups. However In DPOAE test, statistically significant difference was observed between the pre-study basal values and post-study results in groups other than gentamicin + misoprostol group. Additionally, It was found that there was a significant difference in DPOAE response at frequency of 4004 Hz obtained at baseline and after drug exposure according to measurements of epithelial vacuolization in stria vascularis. While ABR threshold values were compared at baseline, there were no significant difference in ABR threshold values of left and right ear between groups. Histopathologically it was also found that there were significant differences measurements of epithelial vacuolization in stria vascularis and inflammation among groups (p < 0.05). CONCLUSION: By these results, misoprostol, a potent antioxidant, has protective effect against cochlear damage, and that may be a safe alternative.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Antioxidantes/farmacologia
Cóclea/efeitos dos fármacos
Doenças Cocleares/induzido quimicamente
Gentamicinas/efeitos adversos
Misoprostol/farmacologia
[Mh] Termos MeSH secundário: Animais
Cóclea/patologia
Doenças Cocleares/prevenção & controle
Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos
Masculino
Emissões Otoacústicas Espontâneas/efeitos dos fármacos
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Gentamicins); 0E43V0BB57 (Misoprostol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


  4 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28252587
[Au] Autor:Morozova SV; Shempeleva LE
[Ad] Endereço:I.M. Sechenov First Moscow State Medical University, Moscow, Russia, 119991.
[Ti] Título:[The peculiar features of the psychosomatic status in the patients presenting with the spondylogenic and cochleovestibular disorders].
[Ti] Título:Osobennosti psikhosomaticheskogo statusa u bol'nykh s vertebrogennymi kokhleovestibuliarnymi narusheniiami..
[So] Source:Vestn Otorinolaringol;82(1):34-37, 2017.
[Is] ISSN:0042-4668
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The objective of the present study was to elucidate the peculiar features of the psychosomatic status in the patients with chronic vertebrogenic and cochleovestibular disorders The psychosomatic status was evaluated in 117 patients at the age from 21 to 65 years presenting with these conditions using the psychometric tests based on the STAI questionnaire (the state-trait anxiety inventory) adapted for the determination of the level of reactive and personal anxiety. It was shown that the vestibular disorders, tympanophonia, and hearing impairment have a negative influence on the psychogenic status of the patients suffering from cochleovestibulopathy. As many as 92.3% of the patients were characterized by the high or moderately high level of reactive and personal anxiety. The depressive conditions of various severity were diagnosed in 29.1% of the patients. The correction of postural muscular disbalance made it possible to achieve the well apparent reduction of the manifestations of reactive anxiety without prescription of the pharmacotherapeutic treatment and thereby to increase the effectiveness of the management of the patients presenting with the vertebrogenic and cochleovestibular disorders.
[Mh] Termos MeSH primário: Ansiedade/diagnóstico
Doenças Cocleares/psicologia
Depressão/diagnóstico
Transtornos da Audição/psicologia
Doenças Vestibulares/psicologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.17116/otorino201782134-37


  5 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27894374
[Au] Autor:Foster PK
[Ad] Endereço:Division of Otolaryngology,Mount Sinai Medical Center,Miami Beach,Florida,USA.
[Ti] Título:Autologous intratympanic blood patch for presumed perilymphatic fistulas.
[So] Source:J Laryngol Otol;130(12):1158-1161, 2016 Dec.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess an alternative to bed rest and surgery for suspected perilymphatic fistulas using intratympanic blood injections. METHOD: A review was conducted of patients' history, physical and audiometric data, before and after treatment by intratympanic blood injections performed from 2009 to 2015. RESULTS: Twelve ears were identified, with trauma associated with air travel, water sports or nose blowing. Ten of these cases had hearing loss, six had vestibular symptoms. Four cases had audiological and vestibular symptoms, two had vestibular symptoms only, and six had audiological symptoms only. Time-to-treat varied from 1 day to 30 days. Magnetic resonance imaging scans were obtained for five cases. Ten cases received steroids. Six out of seven cases showed improvement of hearing loss. Five cases showed positive fistula test results, four with documented resolution. Seven cases had full resolution of all symptoms, four had near-full resolution and one had no improvement. CONCLUSION: Intratympanic blood injections offer an effective alternative to conservative or surgical therapy. Advantages include sooner time-to-treat, lower financial costs and decreased psychosocial burdens. It allows a more flexible and liberal use of a potential definite treatment for perilymphatic fistula.
[Mh] Termos MeSH primário: Sangue
Aqueduto da Cóclea
Doenças Cocleares/terapia
Fístula/terapia
Injeção Intratimpânica
[Mh] Termos MeSH secundário: Adulto
Audiometria de Tons Puros
Aviação
Doenças Cocleares/complicações
Mergulho
Feminino
Fístula/complicações
Glucocorticoides/uso terapêutico
Perda Auditiva/etiologia
Perda Auditiva/fisiopatologia
Perda Auditiva/terapia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Zumbido/etiologia
Zumbido/terapia
Vertigem/etiologia
Vertigem/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


  6 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27630546
[Au] Autor:Chambers AR; Salazar JJ; Polley DB
[Ad] Endereço:Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary Boston, MA, USA.
[Ti] Título:Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation.
[So] Source:Front Neural Circuits;10:72, 2016.
[Is] ISSN:1662-5110
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Neurons at higher stages of sensory processing can partially compensate for a sudden drop in peripheral input through a homeostatic plasticity process that increases the gain on weak afferent inputs. Even after a profound unilateral auditory neuropathy where >95% of afferent synapses between auditory nerve fibers and inner hair cells have been eliminated with ouabain, central gain can restore cortical processing and perceptual detection of basic sounds delivered to the denervated ear. In this model of profound auditory neuropathy, auditory cortex (ACtx) processing and perception recover despite the absence of an auditory brainstem response (ABR) or brainstem acoustic reflexes, and only a partial recovery of sound processing at the level of the inferior colliculus (IC), an auditory midbrain nucleus. In this study, we induced a profound cochlear neuropathy with ouabain and asked whether central gain enabled a compensatory plasticity in the auditory thalamus comparable to the full recovery of function previously observed in the ACtx, the partial recovery observed in the IC, or something different entirely. Unilateral ouabain treatment in adult mice effectively eliminated the ABR, yet robust sound-evoked activity persisted in a minority of units recorded from the contralateral medial geniculate body (MGB) of awake mice. Sound driven MGB units could decode moderate and high-intensity sounds with accuracies comparable to sham-treated control mice, but low-intensity classification was near chance. Pure tone receptive fields and synchronization to broadband pulse trains also persisted, albeit with significantly reduced quality and precision, respectively. MGB decoding of temporally modulated pulse trains and speech tokens were both greatly impaired in ouabain-treated mice. Taken together, the absence of an ABR belied a persistent auditory processing at the level of the MGB that was likely enabled through increased central gain. Compensatory plasticity at the level of the auditory thalamus was less robust overall than previous observations in cortex or midbrain. Hierarchical differences in compensatory plasticity following sensorineural hearing loss may reflect differences in GABA circuit organization within the MGB, as compared to the ACtx or IC.
[Mh] Termos MeSH primário: Córtex Auditivo/fisiopatologia
Percepção Auditiva/fisiologia
Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia
Corpos Geniculados/fisiopatologia
Perda Auditiva Central/fisiopatologia
Colículos Inferiores/fisiopatologia
Plasticidade Neuronal/fisiologia
[Mh] Termos MeSH secundário: Animais
Doenças Cocleares/induzido quimicamente
Modelos Animais de Doenças
Inibidores Enzimáticos/toxicidade
Perda Auditiva Central/induzido quimicamente
Camundongos
Ouabaína/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 5ACL011P69 (Ouabain)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.3389/fncir.2016.00072


  7 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27367352
[Au] Autor:Diab KM; Daikhes NA; Pashchinina OA; Siraeva AP; Kuznetsov AO
[Ad] Endereço:Research Clinical Centre of Otorhinolaryngology, Federal Medico-Biological Agency, Moscow, Russia, 123182.
[Ti] Título:[The non-damaging method for the insertion of a standard electrode for cochlear ossification].
[So] Source:Vestn Otorinolaringol;81(3):54-56, 2016.
[Is] ISSN:0042-4668
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The objective of the present study was to develop the non-damaging method for the insertion of a standard electrode for cochlear ossification with a view to improving the results of hearing and speech rehabilitation of the patients presenting with grade IV sensorineural impairment of hearing. Twenty preparations of the cadaveric temporal bone were used to investigate topographic and anatomical relationships in the main structures of the middle and internal ears, viz. the second cochlear coil, vestibulum and its windows, processus cochleaformis, spiral lamina, and modiolus. The optimal method for the insertion of a standard electrode into the spiral canal of the cochlea after the removal of the ossified structures is proposed. The optimal site for constructing the second colostomy is determined that allows the spiral plate and modiolus to be maximally preserved. The proposed method was employed to treat 11 patients with grade IV sensorineural impairment of hearing and more than 5 mm ossification of the basal cochlear coil. With this method, it proved possible to insert the maximum number of electrodes into the cochlear spiral canal and thereby to obtain excellent results of hearing and speech rehabilitation in the patients with the ossified cochlea.
[Mh] Termos MeSH primário: Doenças Cocleares
Implante Coclear
Implantes Cocleares
Eletrodos Implantados
Ossificação Heterotópica
Complicações Pós-Operatórias/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Cóclea/patologia
Cóclea/cirurgia
Doenças Cocleares/diagnóstico
Doenças Cocleares/fisiopatologia
Doenças Cocleares/cirurgia
Implante Coclear/efeitos adversos
Implante Coclear/instrumentação
Implante Coclear/métodos
Implante Coclear/reabilitação
Feminino
Perda Auditiva/diagnóstico
Perda Auditiva/etiologia
Perda Auditiva/fisiopatologia
Perda Auditiva/cirurgia
Testes Auditivos/métodos
Seres Humanos
Masculino
Ossificação Heterotópica/diagnóstico
Ossificação Heterotópica/fisiopatologia
Ossificação Heterotópica/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE
[do] DOI:10.17116/otorino201681354-56


  8 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27334993
[Au] Autor:Morvan JB; Gempp E; Rivière D; Louge P; Vallee N; Verdalle P
[Ad] Endereço:Ear, Nose and Throat, and Cervicofacial Surgery, Institut de Recherche Biomédicale des Armées Hôpital d'Instruction des Armées Sainte Anne, BP 600 - 83800, Toulon Cedex 9, France, jbmorvan@hotmail.com.
[Ti] Título:Perilymphatic fistula after underwater diving: a series of 11 cases.
[So] Source:Diving Hyperb Med;46(2):72-5, 2016 Jun.
[Is] ISSN:1833-3516
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Onset of cochleovestibular symptoms (hearing loss, dizziness or instability, tinnitus) after a dive (scuba or breath-hold diving) warrants emergency transfer to an otology department. One priority is to investigate the possibility of the development of decompression sickness with a view to hyperbaric oxygen treatment of bubble-induced inner-ear damage. If this injury is ruled out, inner-ear barotrauma should be considered together with its underlying specific injury pattern, perilymphatic fistula. METHODS: We report on a series of 11 cases of perilymphatic fistula following ear barotrauma between 2003 and 2015, eight after scuba diving and three after free diving. All patients underwent a series of laboratory investigations and first-line medical treatment. RESULTS: Seven patients had a perilymphatic fistula in the left ear and four in the right. Eight cases underwent endaural surgical exploration. A fistula of the cochlear fenestra was visualised in seven cases with active perilymph leakage seen in six cases. After temporal fascia grafting, prompt resolution of dizziness occurred, with early, stable, subtotal recovery of hearing in seven. Of six patients in whom tinnitus occurred, this disappeared in two and improved in a further two. Two patients were not operated on because medical treatment had been successful, and one patient refused surgery despite the failure of medical treatment. Median follow-up time was 7.4 years (range 0.3 to 12). CONCLUSION: The diagnosis of perilymphatic fistula is based on clinical assessments and various laboratory findings. When there was strong evidence of this condition, surgery yielded excellent functional outcomes in all patients treated early.
[Mh] Termos MeSH primário: Barotrauma/complicações
Aqueduto da Cóclea/lesões
Doenças Cocleares/etiologia
Mergulho/lesões
Fístula/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Doenças Cocleares/diagnóstico
Doenças Cocleares/cirurgia
Surdez/etiologia
Tontura/etiologia
Fístula/diagnóstico
Fístula/cirurgia
Seres Humanos
Masculino
Meia-Idade
Zumbido/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160623
[Lr] Data última revisão:
160623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE


  9 / 734 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27242366
[Au] Autor:Weegerink NJ; Swinnen FK; Vanakker OM; Casselman JW; Dhooge IJ
[Ad] Endereço:Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium nicoleweegerink@hotmail.com.
[Ti] Título:Phenotype of a Belgian Family With 6p25 Deletion Syndrome.
[So] Source:Ann Otol Rhinol Laryngol;125(9):734-45, 2016 Sep.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The 6p25 deletion syndrome is one of the many syndromes with both hearing impairment as well as vision impairment. However, the audiometric characteristics and radiological findings of patients with 6p25 deletions are only scarcely described in literature. This study focused on characterizing the audiometric and radiological features of a Belgian family with a chromosome 6p25 deletion. OBJECTIVE: To evaluate the hearing impairment, audiometric testing and radiological examination of the temporal bones in 3 family members with a 3.4 Mb deletion in chromosome band 6p25. RESULTS: All 3 family members demonstrated slowly progressive sensorineural or mixed hearing impairment. Radiologic examination revealed thickened and sclerotic stapes in all patients and a minor internal partition type II of the cochlea in 2 patients. CONCLUSION: There is a significant phenotypic variability within and among families with the 6p25 deletion syndrome. A thorough genotype-phenotype correlation is difficult because of the small number of affected patients and the limited clinical data available. More clinical data of families with 6p25 deletions need to be published in order to create a reliable and precise phenotypic characterization. However, our findings can facilitate counseling of hearing impairment caused by 6p25 deletions.
[Mh] Termos MeSH primário: Deleção Cromossômica
Cromossomos Humanos Par 6
Perda Auditiva Condutiva-Neurossensorial Mista/genética
Perda Auditiva Neurossensorial/genética
[Mh] Termos MeSH secundário: Adulto
Segmento Anterior do Olho/anormalidades
Bélgica
Doenças Cocleares/diagnóstico por imagem
Deficiências do Desenvolvimento/genética
Progressão da Doença
Feminino
Fatores de Transcrição Forkhead/genética
Glaucoma/genética
Seres Humanos
Masculino
Miringoesclerose/diagnóstico por imagem
Miringoesclerose/genética
Fenótipo
Esclerose/diagnóstico por imagem
Estribo/diagnóstico por imagem
Estribo/patologia
Substância Branca/anormalidades
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FOXC1 protein, human); 0 (Forkhead Transcription Factors)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160601
[St] Status:MEDLINE
[do] DOI:10.1177/0003489416650687


  10 / 734 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27153330
[Au] Autor:Schubert MC; Migliaccio AA
[Ad] Endereço:*Laboratory of Vestibular NeuroAdaptation, Department of Otolaryngology-Head and Neck Surgery†Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.‡Balance and Vision Laboratory, Neuroscience Research Australia, Sydney§University of New South Wales, Sydney, Australia.
[Ti] Título:Stability of the aVOR to Repeat Head Impulse Testing.
[So] Source:Otol Neurotol;37(6):781-6, 2016 Jul.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The angular vestibulo-ocular reflex (aVOR) is known to be influenced by factors such as arousal and cognition during traditional vestibular function testing. However, the inherent variability of the aVOR to head impulse testing has not been explicitly examined. The purpose of this study was to determine the variability of the aVOR to active and passive head impulses using the gold standard scleral search coil method to record head and eye rotation. STUDY DESIGN: Descriptive. SETTING: Tertiary referral center. PATIENTS: Twenty six healthy control subjects agreed to active and passive horizontal head impulse testing on at least two separate sessions from two unique institutions. An additional 27 individuals with cochlear implantation (CI) underwent passive horizontal and vertical semicircular canal plane head impulse testing. Test sessions were separated from 3 to 210 days in the normal subjects and from 49 to 537 days in the subjects with CI. MAIN OUTCOME MEASURE(S): Reliability of the angular VOR gain (eye velocity/head velocity) over time. RESULTS: In the healthy control subjects, there was no difference in aVOR gain between right and left ears, between session one and session two, or between active (self-generated, 0.99 ±â€Š0.08) or passive (imposed, 1.0 ±â€Š0.08) head impulses. In the patients, we also found the aVOR gain very stable over time. However, the aVOR gains of the patients were different across the semicircular canal planes tested (p < 0.001) with the four vertical semicircular canals having lower aVOR gains than the two horizontal canals. CONCLUSIONS: Our data suggest the aVOR gain is quite stable when tested across unique days in healthy controls and patients with auditory-only inner ear pathology.
[Mh] Termos MeSH primário: Teste do Impulso da Cabeça
Reflexo Vestíbulo-Ocular/fisiologia
[Mh] Termos MeSH secundário: Doenças Cocleares/fisiopatologia
Implantes Cocleares
Feminino
Seres Humanos
Masculino
Valores de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001055



página 1 de 74 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde