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[PMID]:28687425
[Au] Autor:Naganawa S; Sone M
[Ad] Endereço:Department of Radiology, Nagoya University Graduate School of Medicine, Japan. Electronic address: naganawa@med.nagoya-u.ac.jp.
[Ti] Título:Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences.
[So] Source:Am J Otolaryngol;38(5):637-638, 2017 Sep - Oct.
[Is] ISSN:1532-818X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hidropisia Endolinfática
Gadolínio DTPA
[Mh] Termos MeSH secundário: Meios de Contraste
Seres Humanos
Imagem Tridimensional
Imagem por Ressonância Magnética
Doença de Meniere
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Contrast Media); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE


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[PMID]:28631586
[Au] Autor:Jahn AF
[Ad] Endereço:Department of Otolaryngology,Mount Sinai West Hospital,New York,USA.
[Ti] Título:Benign positional vertigo and endolymphatic hydrops: what is the connection?
[So] Source:J Laryngol Otol;131(8):658-660, 2017 Aug.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although benign paroxysmal positional vertigo and endolymphatic hydrops are considered to be distinct diagnoses, a minority of vertiginous patients exhibit features of both conditions. This coincidence has been reported previously in the literature, and is reviewed here in terms of possible aetiology. RESULTS AND CONCLUSION: A new hypothesis to account for both conditions is offered, implicating free-floating degenerating debris from the otolithic apparatus. It is postulated that the gelatinous/proteinaceous component may account for an osmotically induced hydrops, while the calcified fragments may induce positional vertigo.
[Mh] Termos MeSH primário: Vertigem Posicional Paroxística Benigna/etiologia
Hidropisia Endolinfática/etiologia
[Mh] Termos MeSH secundário: Idoso
Vertigem Posicional Paroxística Benigna/patologia
Hidropisia Endolinfática/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Membrana dos Otólitos/patologia
Vestíbulo do Labirinto/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1017/S002221511700130X


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[PMID]:28219165
[Au] Autor:Pan T; Zhao Y; Ding YJ; Lu ZY; Ma FR
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Third Hospital, Peking University, Beijing 100191, China.
[Ti] Título:[The pilot study of type â…  allergic reaction in Meniere's disease patients].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(2):89-92, 2017 Feb 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the correlation between type â…  allergic reaction and pathogenesis of Meniere's disease. A total of 35 (10 male vs. 25 female) patients aged between 21-66 years diagnosed with Meniere's disease were recruited to this study, mean age of them was (47.3±13.6) years. The control group consisted of 15 inpatients (5 male vs. 10 female) with pharyngolaryngeal diseases but without otologic and rhinologic abnormity, mean age was 45.4±12.8 years. Allergic prevalence, serous total immunoglobulin E( tIgE ) levels, serous specific immunoglobulin E( sIgE ) levels and subtypes of T lymphocytes were measured and compared in patients with Meniere's disease and the control group. Severity of vertigo, tinnitus and sensation of fullness were compared between ' patients with or without allergy. Allergic prevalence were significantly different ( - 5.832, <0.05) between patients with ' and the control group(57.1% . 20.0%). Patients with Meniere's disease report higher level of serous tIgE compared with controls, the difference is statistically significant ( =168.000, <0.05). However, positive rates of sIgE of food allergens and inhalant allergens were not significantly different between patients with Meniere's disease and the control group. Scores of vertiginous severity, dizziness handicap inventory (DHI) and tinnitus handicap inventory (THI) were significantly different between Meniere's disease patients with or without allergy ( <0.05). Treg and Treg/Th17 levels ( =26.000) were much higher in Meniere's disease patients with allergy than in the controls( <0.05). Patients with Meniere's disease report higher rate of allergy than the control group. Type â…  allergic reaction is thought to be one of the possible reasons that may induce endolymphatic hydrops and lead to Meniere's disease.
[Mh] Termos MeSH primário: Doença de Meniere/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Alérgenos/imunologia
Estudos de Casos e Controles
Tontura/imunologia
Hidropisia Endolinfática/imunologia
Feminino
Hipersensibilidade Alimentar/imunologia
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Vertigem/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2017.02.003


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[PMID]:28106624
[Au] Autor:Riggs WJ; Catalano DJ; Harris MS; Adunka OF; Moberly AC
[Ad] Endereço:*Department of Otolaryngology, The Ohio State University Wexner Medical Center, Ohio †Pritzker School of Medicine, University of Chicago, Chicago, Illinois.
[Ti] Título:Intraoperative Electrocochleography: A Window Into Endolymphatic Hydrops in a Patient With an Endolymphatic Sac Tumor.
[So] Source:Otol Neurotol;38(4):547-550, 2017 Apr.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops. PATIENTS: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. INTERVENTIONS: Endolymphatic shunt, tumor biopsy, and definitive resection of an endolymphatic sac tumor. MAIN OUTCOME MEASURES: Intraoperative ECochG measurements at three time intervals, using frequency-specific tone bursts and clicks. RESULTS: Across time intervals, the amplitude of ECochG summation potential (SP) responses decreased for tone bursts of all frequencies. On the other hand, the SP response to the click stimulus, and the ratio of the SP to action potential (AP), basically remained unchanged across time points. CONCLUSIONS: Results suggest that the absolute amplitude of the SP response to frequency-specific tone bursts may be more sensitive to inner ear hydrops than the traditionally used SP/AP ratio as a response to click stimuli.
[Mh] Termos MeSH primário: Audiometria de Resposta Evocada/métodos
Neoplasias da Orelha/cirurgia
Hidropisia Endolinfática
Monitorização Neurofisiológica Intraoperatória/métodos
[Mh] Termos MeSH secundário: Adulto
Neoplasias da Orelha/complicações
Hidropisia Endolinfática/etiologia
Saco Endolinfático/cirurgia
Seres Humanos
Masculino
Doença de Meniere/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001340


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[PMID]:28072657
[Au] Autor:Wang F; Lyu H; Zhao M; Sha Y; Zhang F; Cheng Y; Huang W; Tang W; Xie Y; Lu P
[Ad] Endereço:*Department of Radiology †Department of Otolaryngology, Eye and ENT Hospital, Fudan University ‡Siemens Ltd., Shanghai, China.
[Ti] Título:Assessment of Cochlea Endolymphatic Hydrops Using 3-D FLAIR and 3-D Real IR Sequence in Guinea Pigs via 3T MRI After Intratympanic Gadolinium: A Histopathological Comparison.
[So] Source:Otol Neurotol;38(4):585-590, 2017 Apr.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We assessed whether the three-dimensional fluid-attenuated inversion-recovery (3-D FLAIR) and three-dimensional inversion-recovery with real reconstruction (3-D real IR) sequences can be used to detect cochlea endolymphatic hydrops (EHs) in guinea pigs using 3 Tesla magnetic resonance imaging (3T MRI). The results of 3-D real IR imaging were compared with histopathological outcomes. MATERIALS AND METHODS: Fourteen healthy men and women albino guinea pigs were used in this study. Their right ears received procedures that promoted EHs, and their left ears were used as untreated controls. High-resolution 3T MRI, combined with the intratympanic injection of gadolinium (Gd) in both ears, was performed 8 to 12 weeks after surgery. Both sides of the cochlea midmodiolar sections were observed under a light microscope and saved as the histopathological images. The signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) between the T2-weighted 3-D FLAIR and T2-weighted 3-D real IR sequences were compared. The appearance of EHs in the basal, second, third, and apical turns of the cochlea was further evaluated using 3-D FLAIR, 3-D real IR, and the histopathological images. Moreover, the maximum scala media area ratios (SMRs) on the histopathological sections were compared with the grading of the EHs on the 3-D real IR sequence with regard to each turn of the cochlea. RESULTS: Significant differences were found between the 3-D FLAIR and 3-D-real IR sequences with regard to the SNRs and CNRs (p < 0.05): the 3-D FLAIR sequence exhibited higher SNRs (SNRROI: 347.95 ±â€Š105.01; SNRB: 103.28 ±â€Š17.61) compared with the 3-D real IR sequence (SNRROI: 86.71 ±â€Š30.11; SNRB: 11.11 ±â€Š3.45), whereas the 3-D real IR sequence showed higher CNRs (2.78 ±â€Š0.58) compared with the 3-D FLAIR sequence (2.18 ±â€Š0.55). Various degrees of EHs were observed in each turn of the cochlea in the experimental ears on the basis of the histopathological images. Thirteen, 10, 4, and 0 EHs were observed in the basal, second, third, and apical turns of the cochlear using 3-D FLAIR images, respectively, whereas 14, 14, 14, and 13 EHs were found using 3-D real IR images, respectively. Significant differences were found between the two sequences when evaluating the second, third, and apical turns of the cochlear but not with regard to the basal turn (p < 0.05). The SMRs were proportional to the extent of the EHs on 3-D real IR imaging in each turn of the cochlea. CONCLUSIONS: 3-D real IR images are clearer than 3-D FLAIR images, and they can display cochlea EHs more precisely using 3T MRI in guinea pigs. The extent of the EHs on 3-D real IR imaging was more consistent with the histopathological observations in each turn of the cochlea.
[Mh] Termos MeSH primário: Orelha Interna/diagnóstico por imagem
Hidropisia Endolinfática/diagnóstico por imagem
Imagem Tridimensional/métodos
[Mh] Termos MeSH secundário: Animais
Meios de Contraste/administração & dosagem
Modelos Animais de Doenças
Orelha Interna/patologia
Hidropisia Endolinfática/patologia
Feminino
Gadolínio DTPA/administração & dosagem
Cobaias
Imagem por Ressonância Magnética/métodos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001331


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[PMID]:27974068
[Au] Autor:Bento RF; Cisneros JC; De Oliveira Fonseca AC
[Ad] Endereço:Otorhinolaryngology Department,Faculty of Medicine,Hospital das Clínicas,University of São Paulo,Brazil.
[Ti] Título:Endolymphatic sac drainage for the treatment of Ménière's disease.
[So] Source:J Laryngol Otol;131(2):144-149, 2017 Feb.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe the results obtained with endolymphatic sac drainage in patients with Ménière's disease. METHOD: A retrospective case review study was conducted of 95 Ménière's disease patients who underwent endolymphatic sac drainage in a tertiary care referral centre, after failing a long course of medical management. The main outcome measures were vertigo control and hearing preservation. RESULTS: In patients with unilateral disease, vertigo control was obtained in 94.3 per cent of patients. A significant improvement in cochlear function was seen in 14 per cent of patients, and hearing was preserved or improved in 88 per cent. For the bilateral group, vertigo control was obtained in 85.7 per cent of patients and cochlear function improved in 28 per cent. Hearing preservation was attained in 71 per cent of these patients. CONCLUSION: Endolymphatic sac drainage is a good surgical option for patients with incapacitating endolymphatic hydrops, providing a high percentage of vertigo control and hearing preservation.
[Mh] Termos MeSH primário: Saco Endolinfático/cirurgia
Doença de Meniere/cirurgia
Vertigem/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Drenagem
Hidropisia Endolinfática/cirurgia
Feminino
Audição
Seres Humanos
Masculino
Doença de Meniere/fisiopatologia
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215116009713


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[PMID]:27942898
[Au] Autor:Okumura T; Imai T; Takimoto Y; Takeda N; Kitahara T; Uno A; Kamakura T; Osaki Y; Watanabe Y; Inohara H
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
[Ti] Título:Assessment of endolymphatic hydrops and otolith function in patients with Ménière's disease.
[So] Source:Eur Arch Otorhinolaryngol;274(3):1413-1421, 2017 Mar.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Ménière's disease is associated with hydrops of the inner ear endolymphatic space, and histopathologically, the cochlea and vestibule are usually involved. We used gadolinium-enhanced magnetic resonance imaging and measured cervical and ocular vestibular evoked myogenic potentials and the gain in the utricular induced linear vestibulo-ocular reflex to test the hypothesis that vestibular hydrops in Ménière's disease patients is associated with otolith organ dysfunction. We evaluated 21 patients diagnosed with unilateral definitive Ménière's disease using gadolinium magnetic resonance imaging to detect endolymphatic hydrops in the cochlea and vestibule. Cervical and ocular vestibular evoked myogenic potentials and the gain in utricular induced linear vestibulo-ocular reflex during eccentric rotation were measured to assess otolith organ function. For eccentric rotation, patients were rotated while displaced from the axis of rotation, while linear acceleration stimulated the utricle and induced the vestibulo-ocular reflex. Magnetic resonance imaging revealed vestibular hydrops in 14 of 20 patients (70%). Among the 14 patients, ten (71%) had abnormal cervical and three (21%) had abnormal ocular vestibular evoked myogenic potentials. Four patients (4/21, 19%) had abnormal linear vestibulo-ocular reflexes, three of whom also had abnormal ocular vestibular evoked myogenic potentials. Overall, 16 of 17 patients had normal linear vestibulo-ocular reflexes and normal ocular vestibular evoked myogenic potentials. Vestibular endolymphatic hydrops in Ménière's disease patients caused otolith organ dysfunction, mainly in the saccule. The number of Ménière's disease patients with abnormal ocular vestibular evoked myogenic potentials was low (19%), and they also had abnormal utricular induced linear vestibulo-ocular reflexes.
[Mh] Termos MeSH primário: Cóclea/diagnóstico por imagem
Hidropisia Endolinfática/fisiopatologia
Doença de Meniere/fisiopatologia
Reflexo Vestíbulo-Ocular/fisiologia
Potenciais Evocados Miogênicos Vestibulares/fisiologia
Vestíbulo do Labirinto/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Meios de Contraste
Feminino
Gadolínio
Compostos Heterocíclicos
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Compostos Organometálicos
Rotação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Heterocyclic Compounds); 0 (Organometallic Compounds); 0199MV609F (gadoteridol); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-016-4418-2


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[PMID]:27910089
[Au] Autor:Liu IY; Ishiyama A; Sepahdari AR; Johnson K; Ishiyama G
[Ad] Endereço:Department of Head & Neck Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
[Ti] Título:Bilateral Endolymphatic Hydrops in a Patient With Migraine Variant Without Vertigo: A Case Report.
[So] Source:Headache;57(3):455-459, 2017 Mar.
[Is] ISSN:1526-4610
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To use modern high-resolution inner ear imaging modalities to evaluate for endolymphatic hydrops (EH) in a patient with migraine-associated fluctuating hearing loss without vertigo spells or dizziness. BACKGROUND: EH has been well described in patients with Meniere's disease on both human temporal bone studies and modern high-resolution imaging; however, there is no study to date, to our knowledge, that examines the presence of EH in a patient with migraine and bilateral hearing loss. We present the MRI findings using a sequence for detecting EH in a unique case of a patient experiencing migraine headaches accompanied by fluctuating hearing loss without vertigo. METHODS: Magnetic resonance imaging sequences included "cisternographic" three-dimensional T2, and delayed intravenous-enhanced three-dimensional fluid-attenuation inversion recovery (DIVE-3D-FLAIR) sequences, performed with 2350 ms (bright perilymph) and 2050 ms (bright endolymph) inversion times. The bright endolymph images were subtracted from bright perilymph images to create a composite image with bright perilymph, dark endolymph, and intermediate bone signals. RESULTS: A 40-year-old female presented with a left-sided sensorineural hearing loss and severe migraine headaches that began at age 12. For the past year, she experienced severe migraines with right-sided fluctuating sensorineural hearing loss, tinnitus, and aural fullness. Audiometry confirmed a drop of right-sided hearing at times of migraines and increased symptom severity. Vestibular testing was within normal limits. MRI demonstrated the presence of severe bilateral vestibular and cochlear EH. CONCLUSIONS: EH of both the cochlea and vestibule can be present in patients without Meniere's disease or vertigo. The relationship between migraine and Meniere's disease may be complex, as demonstrated in this patient with migraine-associated bilateral hearing loss with MRI documentation of severe bilateral EH. The fact that migraine can be associated with EH is important and demonstrates a potential relationship between the pathophysiology of migraine and that of EH. Given this patient's previous association of migraine and hearing loss at age 12, it appears that migrainous attacks occur simultaneously with the hearing loss, and may be potentially causative of the fluctuating hearing loss, mediated possibly through the development of EH. New imaging modalities allow for studies into the field of inner ear pathology, with significant implications for future research.
[Mh] Termos MeSH primário: Hidropisia Endolinfática/etiologia
Transtornos de Enxaqueca/complicações
[Mh] Termos MeSH secundário: Adulto
Audiometria
Hidropisia Endolinfática/diagnóstico por imagem
Feminino
Seres Humanos
Imagem Tridimensional
Imagem por Ressonância Magnética
Transtornos de Enxaqueca/diagnóstico por imagem
Vertigem/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.1111/head.12976


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[PMID]:27733274
[Au] Autor:Wick CC; Lin SJ; Yu H; Megerian CA; Zheng QY
[Ad] Endereço:Department of Otolaryngology, Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A.. Electronic address: cameron.wick@gmail.com.
[Ti] Título:Treatment of ear and bone disease in the Phex mouse mutant with dietary supplementation.
[So] Source:Am J Otolaryngol;38(1):44-51, 2017 Jan - Feb.
[Is] ISSN:1532-818X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HYPOTHESIS: Phosphorus and vitamin D (calcitriol) supplementation in the Phex mouse, a murine model for endolymphatic hydrops (ELH), will improve otic capsule mineralization and secondarily ameliorate the postnatal development of ELH and sensorineural hearing loss (SNHL). BACKGROUND: Male Phex mice have X-linked hypophosphatemic rickets (XLH), which includes osteomalacia of the otic capsule. The treatment for XLH is supplementation with phosphorus and calcitriol. The effect of this treatment has never been studied on otic capsule bone and it is unclear if improving the otic capsule bone could impact the mice's postnatal development of ELH and SNHL. METHODS: Four cohorts were studied: 1) wild-type control, 2) Phex control, 3) Phex prevention, and 4) Phex rescue. The control groups were not given any dietary supplementation. The Phex prevention group was supplemented with phosphorus added to its drinking water and intraperitoneal calcitriol from postnatal day (P) 7-P40. The Phex rescue group was also supplemented with phosphorus and calcium but only from P20 to P40. At P40, all mice underwent auditory brainstem response (ABR) testing, serum analysis, and temporal bone histologic analysis. Primary outcome was otic capsule mineralization. Secondary outcomes were degree of SNHL and presence ELH. RESULTS: Both treatment groups had markedly improved otic capsule mineralization with less osteoid deposition. The improved otic capsule mineralized did not prevent the development of ELH or SNHL. CONCLUSION: Supplementation with phosphorus and calcitriol improves otic capsule bone morphology in the Phex male mouse but does not alter development of ELH or SNHL.
[Mh] Termos MeSH primário: Doenças Ósseas/terapia
Suplementos Nutricionais
Otopatias/terapia
Perda Auditiva Neurossensorial/terapia
Hipofosfatemia Familiar/terapia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Biópsia por Agulha
Doenças Ósseas/diagnóstico
Calcitriol/farmacologia
Modelos Animais de Doenças
Otopatias/diagnóstico
Hidropisia Endolinfática/diagnóstico
Hidropisia Endolinfática/terapia
Potenciais Evocados Auditivos do Tronco Encefálico
Perda Auditiva Neurossensorial/diagnóstico
Seres Humanos
Hipofosfatemia Familiar/diagnóstico
Imuno-Histoquímica
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Mutantes
Fósforo/farmacologia
Distribuição Aleatória
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
27YLU75U4W (Phosphorus); FXC9231JVH (Calcitriol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27685753
[Au] Autor:Degerman E; In 't Zandt R; Pålbrink A; Eliasson L; Cayé-Thomasen P; Magnusson M
[Ad] Endereço:a Department of Experimental Medical Sciences, Section for Diabetes , Metabolism and Endocrinology Lund University Diabetes Centre , Lund , Sweden.
[Ti] Título:Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.
[So] Source:Acta Otolaryngol;137(1):8-15, 2017 Jan.
[Is] ISSN:1651-2251
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONCLUSION: The data indicate important roles for phosphodiesterase (PDE) 3, 4, 5, and related cAMP and cGMP pools in the regulation of inner ear fluid homeostasis. Thus, dysfunction of these enzymes might contribute to pathologies of the inner ear. OBJECTIVE: The mechanisms underlying endolymphatic hydrops, a hallmark of inner ear dysfunction, are not known in detail; however, altered balance in cAMP and cGMP signaling systems appears to be involved. Key components of these systems are PDEs, enzymes that modulate the amplitude, duration, termination, and specificity of cAMP and cGMP signaling. METHOD: To evaluate the role of PDE3, 4, and 5 and associated cAMP and cGMP pools in inner ear function, the effect of cilostamide (PDE3 inhibitor), rolipram (PDE4 inhibitor), and sildenafil (PDE5 inhibitor), administrated via mini-osmotic pumps, on mouse inner ear fluid homeostasis was evaluated using 9.4T in vivo MRI in combination with intraperitoneally administered Gadolinium contrast. Also, using human saccule as a model, the expression of PDEs and related signaling molecules and targets was studied using immunohistochemistry. RESULTS: PDE3, PDE4, as well as PDE5 inhibitors resulted in the development of endolymphatic hydrops. Furthermore, PDE3B, PDE4D, and some related signaling components were shown to be expressed in the human saccule.
[Mh] Termos MeSH primário: Hidropisia Endolinfática/enzimologia
Inibidores de Fosfodiesterase
Diester Fosfórico Hidrolases/metabolismo
Sáculo e Utrículo/enzimologia
[Mh] Termos MeSH secundário: Animais
Hidropisia Endolinfática/diagnóstico por imagem
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Camundongos Endogâmicos CBA
Quinolonas
Rolipram
Citrato de Sildenafila
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphodiesterase Inhibitors); 0 (Quinolones); 45S5605Q18 (cilostamide); BW9B0ZE037 (Sildenafil Citrate); EC 3.1.4.- (Phosphoric Diester Hydrolases); K676NL63N7 (Rolipram)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE



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