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Pesquisa : C09.218.568.217.500 [Categoria DeCS]
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[PMID]:27779561
[Au] Autor:Hirai C; Yamamoto Y; Takeda T; Tasaki A; Inaba Y; Kiyokawa Y; Suzuki Y; Tsutsumi T
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
[Ti] Título:Nystagmus at the Onset of Vertiginous Attack in Ménière's Disease.
[So] Source:Otol Neurotol;38(1):110-113, 2017 01.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To clarify the direction and characteristics of nystagmus at the onset of a vertiginous attack in Ménière's disease. PATIENTS: Two patients with Ménière's disease, whose nystagmus at the onset of a vertiginous attack was recorded using electronystagmography. INTERVENTIONS: Diagnostic. MAIN OUTCOME MEASURES: Electronystagmographic recordings of nystagmus. RESULTS: In both patients, nystagmus was directed toward the affected side over the entire course of the vertiginous attack. One patient experienced a severe sensation of vertigo and exhibited strong nystagmus from the onset of the attack. The other patient reported a mild sensation of vertigo, which was accompanied by intermittent nystagmus. CONCLUSIONS: Vertiginous attacks in Ménière's disease are accompanied by irritative nystagmus. The intensity and characteristics (e.g., continuous or intermittent expression) of the nystagmus may be associated with pathophysiological severity.
[Mh] Termos MeSH primário: Doença de Meniere/complicações
Nistagmo Patológico/fisiopatologia
Vertigem/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Eletronistagmografia
Feminino
Seres Humanos
Masculino
Meia-Idade
Nistagmo Patológico/etiologia
Vertigem/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29190293
[Au] Autor:Choi JE; Kim YK; Cho YS; Lee K; Park HW; Yoon SH; Kim HJ; Chung WH
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University Hospital, Cheonan, Republic of Korea.
[Ti] Título:Morphological correlation between caloric tests and vestibular hydrops in Ménière's disease using intravenous Gd enhanced inner ear MRI.
[So] Source:PLoS One;12(11):e0188301, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to prove the hypothesis that caloric response in Ménière's disease (MD) is reduced by hydropic expansion of the vestibular labyrinth, not by vestibular hypofunction, by evaluating the correlation morphologically using an intravenous Gadolinium (IV-Gd) inner ear MRI. In study I, the prevalence of abnormal video Head Impulse Test (vHIT) results among the patients with definite unilateral MD (n = 24) and vestibular neuritis (VN) (n = 22) were investigated. All patients showed abnormal canal paresis (CP) (> 26%) on caloric tests. The prevalence of abnormal vHIT in patients with abnormal CP was significantly lower in MD patients (12.5%) than that in VN patients (81.8%) (p < 0.001). In study II, morphological correlation between caloric tests and vestibular hydrops level was evaluated in unilateral MD patients (n = 16) who had normal vHIT results. Eleven patients (61%) had abnormal CP. After taking the images of IV-Gd inner ear MRI, the vestibular hydrops ratio (endolymph volume/total lymph volume = %VH) was measured. In addition, the relative vestibular hydrops ratio (%RVH = (%VHaffected ear-%VHunaffected ear) / (%VHaffected ear + %VHunaffected ear)) was calculated. Each ratio (%VH and %RVH) was compared with average peak slow phase velocity (PSPV) and CP, respectively. In the MD patients, %VH of the affected ear correlated significantly with mean PSPV on the same side (rs = -0.569, p = 0.024), while %RVH correlated significantly with CP (rs = 0.602, p = 0.014). In most MD patients (87.5%) compared to VN patients, vHIT results were normal even though the caloric function was reduced. In addition, the reduced caloric function with normal vHIT was related to the severity of the vestibular hydrops measured by the IV-Gd inner ear MRI. These findings concluded that the abnormal caloric tests with normal vHIT in MD indicated severe endolymphatic hydrops rather than vestibular hypofunction.
[Mh] Termos MeSH primário: Testes Calóricos
Gadolínio/administração & dosagem
Imagem por Ressonância Magnética/métodos
Doença de Meniere/fisiopatologia
Vestíbulo do Labirinto/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188301


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[PMID]:28787010
[Au] Autor:Li L; Wang Y; An L; Kong X; Huang T
[Ad] Endereço:Department of Otorhinolaryngology and Head & Neck, China-Japan Union Hospital of Jilin University, Changchun, China.
[Ti] Título:A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Menière's disease.
[So] Source:PLoS One;12(8):e0182592, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As a chronic illness derived from hair cells of the inner ear, Menière's disease (MD) negatively influences the quality of life of individuals and leads to a number of symptoms, such as dizziness, temporary hearing loss, and tinnitus. The complete identification of novel genes related to MD would help elucidate its underlying pathological mechanisms and improve its diagnosis and treatment. In this study, a network-based method was developed to identify novel MD-related genes based on known MD-related genes. A human protein-protein interaction (PPI) network was constructed using the PPI information reported in the STRING database. A classic ranking algorithm, the random walk with restart (RWR) algorithm, was employed to search for novel genes using known genes as seed nodes. To make the identified genes more reliable, a series of screening tests, including a permutation test, an interaction test and an enrichment test, were designed to select essential genes from those obtained by the RWR algorithm. As a result, several inferred genes, such as CD4, NOTCH2 and IL6, were discovered. Finally, a detailed biological analysis was performed on fifteen of the important inferred genes, which indicated their strong associations with MD.
[Mh] Termos MeSH primário: Algoritmos
Biologia Computacional/métodos
Doença de Meniere/genética
[Mh] Termos MeSH secundário: Mapeamento de Interação de Proteínas
Processos Estocásticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182592


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[PMID]:28719825
[Au] Autor:Chang CM; Young YH; Jaw FS; Wang CT; Cheng PW
[Ad] Endereço:Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.
[Ti] Título:Degeneration of the vestibular nerve in unilateral Meniere's disease evaluated by galvanic vestibular-evoked myogenic potentials.
[So] Source:Clin Neurophysiol;128(9):1617-1624, 2017 Sep.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The staging system of Meniere's disease utilizes audiograms to probe cochlear dysfunction. We explored the addition of galvanic vestibular-evoked myogenic potentials (VEMP) to further explore vestibular function. METHODS: Seventy patients with unilateral Meniere's disease were enrolled in this study. Within 2weeks of diagnosis, all subjects underwent pure tone audiometry, cervical and ocular VEMP, and caloric test. The prevalence of abnormal tests and the VEMP characteristic parameters such as latencies and amplitudes were analyzed. RESULTS: In affected ears, the abnormal rate of acoustic cVEMPs, galvanic cVEMPs, vibratory oVEMPs and galvanic oVEMPs was 37%, 17%, 20%, and 9%, respectively. No significant differences existed in VEMP latencies and amplitudes between affected ears and unaffected ears. CONCLUSIONS: The impairment of otolithic organs was found to be more than that of vestibular afferents. The deterioration of the saccule was more than that of the utricle, whereas retrolabyrinthine degeneration of sacculo-collic reflex and vestibulo-ocular reflex was similar. SIGNIFICANCE: This study is the first to use an electrophysiological test to evaluate the retrolabyrinthine function of patients with unilateral Meniere's disease.
[Mh] Termos MeSH primário: Resposta Galvânica da Pele/fisiologia
Doença de Meniere/fisiopatologia
Degeneração Neural/fisiopatologia
Potenciais Evocados Miogênicos Vestibulares/fisiologia
Nervo Vestibular/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Audiometria/métodos
Eletromiografia/métodos
Feminino
Seres Humanos
Masculino
Doença de Meniere/diagnóstico
Meia-Idade
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


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[PMID]:28687425
[Au] Autor:Naganawa S; Sone M
[Ad] Endereço:Department of Radiology, Nagoya University Graduate School of Medicine, Japan. Electronic address: naganawa@med.nagoya-u.ac.jp.
[Ti] Título:Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences.
[So] Source:Am J Otolaryngol;38(5):637-638, 2017 Sep - Oct.
[Is] ISSN:1532-818X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hidropisia Endolinfática
Gadolínio DTPA
[Mh] Termos MeSH secundário: Meios de Contraste
Seres Humanos
Imagem Tridimensional
Imagem por Ressonância Magnética
Doença de Meniere
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Contrast Media); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE


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[PMID]:28623066
[Au] Autor:Tarnutzer AA; Bockisch CJ; Buffone E; Weber KP
[Ad] Endereço:Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland. Electronic address: alexander.tarnutzer@access.uzh.ch.
[Ti] Título:Association of posterior semicircular canal hypofunction on video-head-impulse testing with other vestibulo-cochlear deficits.
[So] Source:Clin Neurophysiol;128(8):1532-1541, 2017 Aug.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The video-head-impulse test (vHIT) provides a functional assessment of all six semicircular canals (SCC). Occasionally isolated loss of the posterior canal(s) (ILPC) is diagnosed, though this finding is poorly characterized. Here we assessed how accurate that diagnosis is by measuring the co-occurrence of abnormalities on caloric irrigation, vestibular-evoked myogenic-potentials and audiometry. METHODS: We identified 52 patients with ILPC (unilateral=40, bilateral=12). We determined vHIT-gains and saccade-amplitudes and correlated vHIT-findings with other vestibulo-cochlear tests. RESULTS: The most frequent diagnoses were history of vestibular neuritis (13/52), Menière's disease (12/52) and vertigo/dizziness of unclear origin (13/52). Unilateral ILPC on vHIT was accompanied by a deficient horizontal canal on calorics, saccular and/or utricular deficits ipsilesionally in 33/40 (83%), while ipsilesional hearing-loss was noted in 24/40 (60%). Involvement of other sensors was highest for vestibular schwannoma (100%) and history of vestibular neuritis (92%). Bilateral deficits in ≥1 vestibulo-cochlear sensor(s) were noted in 2/12 cases with bilateral ILPC. CONCLUSIONS: >80% of patients with unilateral ILPC had additional deficits of other parts of the vestibular organ, while this rate was ≤20% for patients with bilateral ILPC. SIGNIFICANCE: Dizzy patients should receive testing of the posterior canals and if abnormalities are observed, additional vestibulo-cochlear testing should be obtained.
[Mh] Termos MeSH primário: Cóclea/fisiopatologia
Teste do Impulso da Cabeça/métodos
Canais Semicirculares/fisiopatologia
Vestíbulo do Labirinto/fisiopatologia
Gravação em Vídeo/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Tontura/diagnóstico
Tontura/fisiopatologia
Feminino
Seres Humanos
Masculino
Doença de Meniere/diagnóstico
Doença de Meniere/fisiopatologia
Meia-Idade
Neuroma Acústico/diagnóstico
Neuroma Acústico/fisiopatologia
Estudos Retrospectivos
Neuronite Vestibular/diagnóstico
Neuronite Vestibular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170618
[St] Status:MEDLINE


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[PMID]:28594693
[Au] Autor:Pullen RL
[Ad] Endereço:Richard L. Pullen, Jr., is a professor of nursing at Texas Tech University Health Sciences Center School of Nursing in Lubbock, Tex.
[Ti] Título:Navigating the challenges of Meniere disease.
[So] Source:Nursing;47(7):38-45, 2017 07.
[Is] ISSN:1538-8689
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doença de Meniere/enfermagem
[Mh] Termos MeSH secundário: Gentamicinas/administração & dosagem
Seres Humanos
Injeção Intratimpânica
Masculino
Doença de Meniere/complicações
Doença de Meniere/fisiopatologia
Meia-Idade
Avaliação em Enfermagem
Diagnóstico de Enfermagem
Educação de Pacientes como Assunto
Vertigem/tratamento farmacológico
Vertigem/etiologia
Vertigem/enfermagem
Vertigem/psicologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gentamicins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1097/01.NURSE.0000520504.06428.ce


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[PMID]:28583226
[Au] Autor:Patel VA; Oberman BS; Zacharia TT; Isildak H
[Ad] Endereço:Department of Surgery, Division of Otolaryngology - Head and Neck Surgery,Pennsylvania State University, College of Medicine,Hershey,USA.
[Ti] Título:Magnetic resonance imaging findings in Ménière's disease.
[So] Source:J Laryngol Otol;131(7):602-607, 2017 Jul.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To identify and evaluate cranial magnetic resonance imaging findings associated with Ménière's disease. METHODS: Seventy-eight patients with a documented diagnosis of Ménière's disease and 35 controls underwent 1.5 T or 3 T magnetic resonance imaging of the brain. Patients also underwent otological, vestibular and audiometric examinations. RESULTS: Lack of visualisation of the left and right vestibular aqueducts was identified as statistically significant amongst Ménière's disease patients (left, p = 0.0001, odds ratio = 0.02; right, p = 0.0004, odds ratio = 0.03). Both vestibular aqueducts were of abnormal size in the Ménière's disease group, albeit with left-sided significance (left, p = 0.008, odds ratio = 10.91; right, p = 0.49, odds ratio = 2.47). CONCLUSION: Lack of vestibular aqueduct visualisation on magnetic resonance imaging was statistically significant in Ménière's disease patients compared to the general population. The study findings suggest that magnetic resonance imaging can be useful to rule out retrocochlear pathology and provide radiological data to support the clinical diagnosis of Ménière's disease.
[Mh] Termos MeSH primário: Imagem por Ressonância Magnética
Doença de Meniere/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Valores de Referência
Estudos Retrospectivos
Aqueduto Vestibular/anormalidades
Aqueduto Vestibular/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001086


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[PMID]:28534686
[Au] Autor:Chiarella G; Russo D; Monzani F; Petrolo C; Fattori B; Pasqualetti G; Cassandro E; Costante G
[Ti] Título:HASHIMOTO THYROIDITIS AND VESTIBULAR DYSFUNCTION.
[So] Source:Endocr Pract;23(7):863-868, 2017 Jul.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this review was to analyze the existing literature concerning the relationship between Hashimoto thyroiditis (HT) and vestibular dysfunction. METHODS: We used electronic databases (PubMed, EMBASE, Cochrane Library) to search and collect all published articles about the association between HT and vestibular disorders. RESULTS: Several observational and retrospective studies have postulated a relationship between thyroid autoimmunity and vestibular disorders. In most cases, an appropriate control group was lacking, and the impact of thyroid functional status could not precisely be established. In recent years, two well-designed prospective studies have provided convincing evidence that the association is not random. One article reported that patients with Ménière disease (MD) had a significantly higher prevalence of positive anti-thyroid autoantibody as compared to healthy controls. Moreover, more than half of MD patients had either positive anti-thyroid or non-organ-specific autoantibody titers, compared to less than 30% of both patients with unilateral vestibular paresis without cochlear involvement and healthy controls. Another study found that patients with benign paroxysmal positional vertigo (BPPV) had significantly higher serum thyroid-stimulating hormone and antithyroid autoantibody levels than healthy controls. Additionally, almost one-fifth of euthyroid patients with HT had signs of BPPV. CONCLUSION: The published results indicate that patients with MD or BPPV are potential candidates to also develop HT. Thus, in HT patients, the presence of even slight symptoms or signs potentially related to vestibular lesions should be carefully investigated. ABBREVIATIONS: AITD = autoimmune thyroid disease; BPPV = benign paroxysmal positional vertigo; EH = endolymphatic hydrops; HT = Hashimoto thyroiditis; L-T = L-thyroxine; MD = Ménière disease; PS = Pendred syndrome; Tg = thyroglobulin; TPO = thyroid peroxidase; TSH = thyroid-stimulating hormone.
[Mh] Termos MeSH primário: Autoanticorpos/imunologia
Vertigem Posicional Paroxística Benigna/imunologia
Doença de Hashimoto/imunologia
Doença de Meniere/imunologia
[Mh] Termos MeSH secundário: Doenças Autoimunes/complicações
Doenças Autoimunes/imunologia
Vertigem Posicional Paroxística Benigna/complicações
Doença de Hashimoto/complicações
Seres Humanos
Doença de Meniere/complicações
Doenças Vestibulares/complicações
Doenças Vestibulares/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantibodies)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.4158/EP161635.RA


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[PMID]:28502274
[Au] Autor:Schneiders SMD; Rainsbury JW; Hensen EF; Irving RM
[Ad] Endereço:Department of ENT Surgery,Queen Elizabeth Hospital,Birmingham,UK.
[Ti] Título:Superior petrosal sinus causing superior canal dehiscence syndrome.
[So] Source:J Laryngol Otol;131(7):593-597, 2017 Jul.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine signs and symptoms for superior canal dehiscence syndrome caused by the superior petrosal sinus. METHODS: A review of the English-language literature on PubMed and Embase databases was conducted, in addition to a multi-centre case series report. RESULTS: The most common symptoms of 17 patients with superior petrosal sinus related superior canal dehiscence syndrome were: hearing loss (53 per cent), aural fullness (47 per cent), pulsatile tinnitus (41 per cent) and pressure-induced vertigo (41 per cent). The diagnosis was made by demonstration of the characteristic bony groove of the superior petrosal sinus and the 'cookie bite' out of the superior semicircular canal on computed tomography imaging. CONCLUSION: Pulsatile tinnitus, hearing loss, aural fullness and pressure-induced vertigo are the most common symptoms in superior petrosal sinus related superior canal dehiscence syndrome. Compared to superior canal dehiscence syndrome caused by the more common apical location of the dehiscence, pulsatile tinnitus and exercise-induced vertigo are more frequent, while sound-induced vertigo and autophony are less frequent. There is, however, considerable overlap between the two subtypes. The distinction cannot as yet be made on clinical signs and symptoms alone, and requires careful analysis of computed tomography imaging.
[Mh] Termos MeSH primário: Seio Cavernoso
Doenças do Labirinto/diagnóstico
Doenças do Labirinto/etiologia
Canais Semicirculares
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Aumento da Imagem
Interpretação de Imagem Assistida por Computador
Masculino
Doença de Meniere/diagnóstico
Doença de Meniere/etiologia
Meia-Idade
Equilíbrio Postural/fisiologia
Transtornos das Sensações/diagnóstico
Transtornos das Sensações/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117001013



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