Base de dados : MEDLINE
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[PMID]:28555605
[Au] Autor:Eeten EV; Faber H; Kunst D
[Ad] Endereço:Department of Otolaryngology, Radboud University Medical Center, Nijmegen, Netherlands. FaberH@zgv.nl.
[Ti] Título:Surgical Treatment for Epstein-Barr Virus Otomastoiditis Complicated by Facial Nerve Paralysis: A Case Report of Two Young Brothers and Review of Literature.
[So] Source:J Int Adv Otol;13(1):143-146, 2017 Apr.
[Is] ISSN:1308-7649
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:We report the case of two young brothers with Epstein-Barr virus (EBV) otomastoiditis complicated by a facial nerve paralysis. The boys, aged 7 months (patient A) and 2 years and 8 months (patient B), were diagnosed with a facial nerve paralysis House-Brackmann (HB) grade IV (A) and V (B). After unsuccessful pharmacological treatment, patient A underwent mastoidectomy and atticoantrotomy and patient B underwent a transmastoidal surgical decompression of the facial nerve. They recovered to HB grades I and II facial nerve palsy (FNP), respectively. Although rare and relatively unknown, EBV should be considered in the differential diagnosis of children with FNP of unknown cause. Surgical intervention may be a viable therapy with good recovery.
[Mh] Termos MeSH primário: Infecções por Vírus Epstein-Barr/complicações
Paralisia Facial
Processo Mastoide
Mastoidite
Otite
Irmãos
[Mh] Termos MeSH secundário: Pré-Escolar
Paralisia Facial/diagnóstico
Paralisia Facial/cirurgia
Paralisia Facial/virologia
Seres Humanos
Lactente
Masculino
Processo Mastoide/cirurgia
Mastoidite/diagnóstico
Mastoidite/cirurgia
Mastoidite/virologia
Otite/diagnóstico
Otite/cirurgia
Otite/virologia
Procedimentos Cirúrgicos Otológicos/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.5152/iao.2017.2788


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[PMID]:28539157
[Ti] Título:This Month in Aerospace Medicine History.
[So] Source:Aerosp Med Hum Perform;88(6):610, 2017 Jun 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Medicina Aeroespacial/história
[Mh] Termos MeSH secundário: Administração Tópica
Doenças Cardiovasculares/sangue
Doenças Cardiovasculares/epidemiologia
Dimetil Sulfóxido/uso terapêutico
Bolsas de Estudo
Depuradores de Radicais Livres/uso terapêutico
História do Século XX
Seres Humanos
Lipídeos/sangue
Otite/tratamento farmacológico
Pilotos/estatística & dados numéricos
Sinusite/tratamento farmacológico
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Lipids); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4832.2017


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[PMID]:28372718
[Au] Autor:Tasche KK; Chang KE
[Ad] Endereço:University of Iowa, Iowa City, IA, USA.
[Ti] Título:Otolaryngologic Emergencies in the Primary Care Setting.
[So] Source:Med Clin North Am;101(3):641-656, 2017 May.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most otolaryngology-related complaints are straightforward and easily recognized and treated. However, given the proximity of the ears, nose, and throat to numerous vital structures in the head and neck, the potential for serious consequences exists if disease processes go unrecognized and untreated. This article serves to familiarize the primary care provider with the clinical presentation of various complications associated with common otolaryngologic complaints. Clinicians who care for patients presenting with otolaryngologic complaints should keep these entities in mind and attempt to rule out any serious complication.
[Mh] Termos MeSH primário: Emergências
Otorrinolaringopatias/complicações
Atenção Primária à Saúde
[Mh] Termos MeSH secundário: Corpos Estranhos/complicações
Seres Humanos
Otite/complicações
Doenças Faríngeas/complicações
Sinusite/complicações
Ferimentos e Lesões/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:28189351
[Au] Autor:Espenel S; Garcia MA; Guy JB; Vallard A; Ben Mrad M; Langrand-Escure J; El Meddeb Hamrouni A; Trone JC; Xia Y; Rancoule C; Magné N
[Ad] Endereço:Département de radiothérapie, institut de cancérologie Lucien-Neuwirth, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
[Ti] Título:[Ototoxicity in head and neck cancers after radiotherapy and chemoradiotherapy: From primary prevention to tertiary prevention].
[Ti] Título:Ototoxicité radio-induite et chimio-induite dans les cancers ORL : de la prévention primaire à la prévention tertiaire..
[So] Source:Cancer Radiother;21(1):77-83, 2017 Feb.
[Is] ISSN:1769-6658
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Each year, 15,000 head and neck cancer are treated in France. Prognosis is steadily improving. Consequently, limitation of late toxicities becomes essential. Ototoxicity is common, disabling and undervalued. We aimed to inventory primary, secondary and tertiary prevention measures to reduce ototoxicity induced by radiotherapy and chemotherapy, as well as its impact on quality of life of patients treated for head and neck cancer. External radiation therapy induced 30 to 40% of ototoxicity, including irreversible sensorineural hearing loss. Primary prevention of this risk is based on limiting the dose to the cochlea: 40Gy in case of radiotherapy alone, 10Gy during concomitant chemoradiotherapy with cisplatin. Dose gradients allowed by intensity-modulated radiotherapy help respecting these limits. Concurrent chemotherapy with high dose cisplatin (100mg/m ) also causes hearing loss by cochlear damages. Prescription of carboplatin-5-fluorouracil combination or cetuximab should be preferred in case of high risk of ototoxicity. This risk must be precisely evaluated before treatment. Ototoxicity monitoring during treatment allows early management, and lower long-term impact. Radiosensitivity predictive tests and research of genetic factors predisposing to chemo-induced ototoxicity should enable optimization of therapeutic choices and monitoring.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Neoplasias de Cabeça e Pescoço/terapia
Perda Auditiva Condutiva/prevenção & controle
Perda Auditiva Neurossensorial/prevenção & controle
Lesões por Radiação/prevenção & controle
Radioterapia de Intensidade Modulada/efeitos adversos
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Quimiorradioterapia/efeitos adversos
Quimiorradioterapia/métodos
Cisplatino/administração & dosagem
Cisplatino/efeitos adversos
Cóclea/efeitos dos fármacos
Cóclea/efeitos da radiação
Terapia Combinada
Dor de Orelha/induzido quimicamente
Dor de Orelha/etiologia
Neoplasias de Cabeça e Pescoço/radioterapia
Perda Auditiva Condutiva/etiologia
Perda Auditiva Neurossensorial/induzido quimicamente
Perda Auditiva Neurossensorial/etiologia
Seres Humanos
Órgãos em Risco
Otite/induzido quimicamente
Otite/etiologia
Prevenção Primária/métodos
Qualidade de Vida
Lesões por Radiação/etiologia
Tolerância a Radiação
Dosagem Radioterapêutica
Prevenção Secundária/métodos
Prevenção Terciária/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


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[PMID]:28093111
[Au] Autor:Teixeira AG; McArt JA; Bicalho RC
[Ad] Endereço:Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
[Ti] Título:Efficacy of tildipirosin metaphylaxis for the prevention of respiratory disease, otitis and mortality in pre-weaned Holstein calves.
[So] Source:Vet J;219:44-48, 2017 Jan.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the efficacy of two metaphylactic approaches (long acting antibiotic injected once at 10 days of life or twice at 10 and 35 days of life) on the prevention of bovine respiratory disease (BRD), otitis and mortality in high-risk group-housed pre-weaned Holstein heifer calves. The antibiotic of choice for the metaphylactic approach was a long acting macrolide (tildipirosin) administered subcutaneously at the base of the neck at a dose of 1 mL per 45 kg body weight. A clinical trial was carried out on one dairy farm with random allocation of newborn calves to one of three treatments: (1) control (CTR); (2) one injection at 10 days of life (M1); and (3) two injections at 10 and 35 days of life (M2). Study heifers (n = 795) were reared in group pens of 25 calves per pen and fed unrestricted acidified non-saleable milk from day 1 to day 65 of life. Cox proportional hazard and general linear mixed models were used to evaluate the effect of treatment on mortality, BRD and otitis, and average daily weight gain. The birth weights, proportions of calves with inadequate transfer of passive immunity, proportions of calves born from primiparous dams and proportions of calves born from assisted parturitions were not different among CTR, M1 and M2 treatments. A significantly lower hazard of being affected with BRD and/or otitis (but not for BRD or otitis alone) was observed for M1 (hazard ratio, HR = 0.70, P = 0.009) and M2 (HR = 0.72, P = 0.01) when compared to the CTR group. Metaphylactic treatments had no effect on mortality, otitis and average daily weight gain during the pre-weaning period.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Antibioticoprofilaxia/veterinária
Complexo Respiratório Bovino/prevenção & controle
Otite/veterinária
Tilosina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Complexo Respiratório Bovino/microbiologia
Bovinos
Feminino
Longevidade/efeitos dos fármacos
Otite/metabolismo
Otite/prevenção & controle
Tilosina/uso terapêutico
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (20,23-dipiperidinyl-mycaminosyl-tylonolide); 0 (Anti-Bacterial Agents); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


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[PMID]:28031178
[Au] Autor:Kirkham LS; Wiertsema SP; Corscadden KJ; Mateus T; Mullaney GL; Zhang G; Richmond PC; Thornton RB
[Ad] Endereço:School of Paediatrics and Child Health, University of Western Australia, Perth, Australia lea-ann.kirkham@uwa.edu.au.
[Ti] Título:Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides.
[So] Source:Clin Vaccine Immunol;24(3), 2017 Mar.
[Is] ISSN:1556-679X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The pneumococcus is a major otitis media (OM) pathogen, but data are conflicting regarding whether otitis-prone children have impaired humoral immunity to pneumococcal antigens. We and others have shown that otitis-prone and healthy children have similar antibody titers to pneumococcal proteins and polysaccharides (vaccine and nonvaccine types); however, the quality of antibodies from otitis-prone children has not been investigated. Antibody function, rather than titer, is considered to be a better correlate of protection from pneumococcal disease. Therefore, we compared the capacities of antibodies from otitis-prone (cases) and healthy (controls) children to neutralize pneumolysin, the pneumococcal toxin currently in development as a vaccine antigen, and to opsonize pneumococcal vaccine and nonvaccine serotypes. A pneumolysin neutralization assay was conducted on cholesterol-depleted complement-inactivated sera from 165 cases and 61 controls. A multiplex opsonophagocytosis assay (MOPA) was conducted on sera from 20 cases and 20 controls. Neutralizing and opsonizing titers were calculated with antigen-specific IgG titers to determine antibody potency for pneumolysin, pneumococcal conjugate vaccine (PCV) polysaccharides, and non-PCV polysaccharides. There was no significant difference in antibody potencies between cases and controls for the antigens tested. Antipneumolysin neutralizing titers increased with the number of episodes of acute OM, but antibody potency did not. Pneumolysin antibody potency was lower in children colonized with pneumococci than in noncarriers, and this was significant for the otitis-prone group ( < 0.05). The production of functional antipneumococcal antibodies in otitis-prone children demonstrates that they respond to the current PCV and are likely to respond to pneumolysin-based vaccines as effectively as healthy children.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/sangue
Otite/imunologia
Infecções Pneumocócicas/imunologia
Polissacarídeos Bacterianos/imunologia
Estreptolisinas/imunologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/imunologia
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Imunoglobulina G/sangue
Lactente
Masculino
Testes de Neutralização
Proteínas Opsonizantes/sangue
Fagocitose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Bacterial Proteins); 0 (Immunoglobulin G); 0 (Opsonin Proteins); 0 (Polysaccharides, Bacterial); 0 (Streptolysins); 0 (plY protein, Streptococcus pneumoniae)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE


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[PMID]:27956101
[Au] Autor:Takano K; Yamamoto M; Takahashi H; Himi T
[Ad] Endereço:Department of Otolaryngology, Sapporo Medical University School of Medicine, S1W16, Chuo-ku, Sapporo 060-8543, Japan. Electronic address: kent@sapmed.ac.jp.
[Ti] Título:Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease.
[So] Source:Auris Nasus Larynx;44(1):7-17, 2017 Feb.
[Is] ISSN:1879-1476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:IgG4-related disease (IgG4-RD) is a chronic inflammatory disorder, characterized by elevated serum IgG4 levels as well as abundant infiltration of IgG4-positive plasmacytes and fibrosis in various organs, including the head and neck region. In particular, the salivary glands, orbit, and thyroid are common sites of disease involvement. IgG4-RD is diagnosed based on various clinical, serological, and histopathological findings, none of which are pathognomonic. Hence, various differential diagnoses, which exhibit elevated serum IgG4 levels and infiltration of IgG4-postive cells into tissues, need to be excluded, especially malignant diseases and mimicking disorders. Systemic corticosteroids are generally effective in inducing IgG4-RD remission; however, recurrent or refractory cases are common. In addition, although the pathogenic mechanisms of IgG4-RD remain unclear, an antigen-driven inflammatory condition is believed to be involved. Recent studies have indicated the important pathogenic role of B cell/T cell collaboration and innate immunity in this disease. Nevertheless, additional research and discussions are needed to resolve many remaining questions. In this review, we provide an overview of the recent insights on the history, clinical features, diagnosis, and treatment of IgG4-RD in the head and neck region. Furthermore, we have also addressed the pathogenesis of this disease.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Dacriocistite/imunologia
Imunoglobulina G/imunologia
Rinite/imunologia
Sialadenite/imunologia
Sinusite/imunologia
Tireoidite Autoimune/imunologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Doenças Autoimunes/tratamento farmacológico
Hipofisite Autoimune/tratamento farmacológico
Hipofisite Autoimune/imunologia
Dacriocistite/tratamento farmacológico
Seres Humanos
Linfadenite/tratamento farmacológico
Linfadenite/imunologia
Mastoidite/tratamento farmacológico
Mastoidite/imunologia
Neurite (Inflamação)/tratamento farmacológico
Neurite (Inflamação)/imunologia
Otite/tratamento farmacológico
Otite/imunologia
Rinite/tratamento farmacológico
Sialadenite/tratamento farmacológico
Sinusite/tratamento farmacológico
Tireoidite Autoimune/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Immunoglobulin G)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170723
[Lr] Data última revisão:
170723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


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[PMID]:27889361
[Au] Autor:Aksamit TR; O'Donnell AE; Barker A; Olivier KN; Winthrop KL; Daniels MLA; Johnson M; Eden E; Griffith D; Knowles M; Metersky M; Salathe M; Thomashow B; Tino G; Turino G; Carretta B; Daley CL; Bronchiectasis Research Registry Consortium
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. Electronic address: aksamit.timothy@mayo.edu.
[Ti] Título:Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry.
[So] Source:Chest;151(5):982-992, 2017 May.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We sought to describe the characteristics of adult patients with bronchiectasis enrolled in the US Bronchiectasis Research Registry (BRR). METHODS: The BRR is a database of patients with non-cystic-fibrosis bronchiectasis (NCFB) enrolled at 13 sites in the United States. Baseline demographic, spirometric, imaging, microbiological, and therapeutic data were entered into a central Internet-based database. Patients were subsequently analyzed by the presence of NTM. RESULTS: We enrolled 1,826 patients between 2008 and 2014. Patients were predominantly women (79%), white (89%), and never smokers (60%), with a mean age of 64 ± 14 years. Sixty-three percent of the patients had a history of NTM disease or NTM isolated at baseline evaluation for entry into the BRR. Patients with NTM were older, predominantly women, and had bronchiectasis diagnosed at a later age than those without NTM. Gastroesophageal reflux disease (GERD) was more common in those with NTM, whereas asthma, primary immunodeficiency, and primary ciliary dyskinesia were more common in those without NTM. Fifty-one percent of patients had spirometric evidence of airflow obstruction. Patients with NTM were more likely to have diffusely dilated airways and tree-in-bud abnormalities. Pseudomonas and Staphylococcus aureus isolates were cultured less commonly in patients with NTM. Bronchial hygiene measures were used more often in those with NTM, whereas antibiotics used for exacerbations, rotating oral antibiotics, steroid use, and inhaled bronchodilators were more commonly used in those without NTM. CONCLUSIONS: Adult patients with bronchiectasis enrolled in the US BRR are described, with differences noted in demographic, radiographic, microbiological, and treatment variables based on stratification of the presence of NTM.
[Mh] Termos MeSH primário: Bronquiectasia/epidemiologia
Síndromes de Imunodeficiência/epidemiologia
Síndrome de Kartagener/epidemiologia
Infecções por Micobactéria não Tuberculosa/epidemiologia
Sistema de Registros
[Mh] Termos MeSH secundário: Adulto
Afroamericanos/estatística & dados numéricos
Idoso
Animais
Asma/epidemiologia
Pesquisa Biomédica
Bronquiectasia/microbiologia
Bronquiectasia/fisiopatologia
Comorbidade
Grupos Étnicos/estatística & dados numéricos
Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos
Feminino
Volume Expiratório Forçado
Refluxo Gastroesofágico/epidemiologia
Hispano-Americanos/estatística & dados numéricos
Seres Humanos
Seguro Saúde
Masculino
Meia-Idade
Infecções por Micobactéria não Tuberculosa/microbiologia
Micobactérias não Tuberculosas
Otite/epidemiologia
Pseudomonas
Infecções por Pseudomonas/epidemiologia
Rinite/epidemiologia
Sinusite/epidemiologia
Fumar/epidemiologia
Espirometria
Infecções Estafilocócicas/epidemiologia
Staphylococcus aureus
Tomografia Computadorizada por Raios X
Estados Unidos/epidemiologia
Capacidade Vital
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


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[PMID]:27426073
[Au] Autor:Morris DO; Davis MF; Palmeiro BS; O'Shea K; Rankin SC
[Ad] Endereço:Department of Clinical Studies - Philadelphia, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA.
[Ti] Título:Molecular and epidemiological characterization of canine Pseudomonas otitis using a prospective case-control study design.
[So] Source:Vet Dermatol;28(1):118-e25, 2017 Feb.
[Is] ISSN:1365-3164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen of the canine ear canal and occupies aquatic habitats in the environment. Nosocomial and zoonotic transmission of P. aeruginosa have been documented, including clonal outbreaks. HYPOTHESIS/OBJECTIVES: The primary objective of this study was to assess various environmental exposures as potential risk factors for canine Pseudomonas otitis. It was hypothesized that isolates derived from infected ears would be clonal to isolates derived from household water sources and the mouths of human and animal companions of the study subjects. ANIMALS: Seventy seven privately owned dogs with otitis were enrolled, along with their human and animal household companions, in a case-control design. METHODS: Data on potential risk factors for Pseudomonas otitis were collected. Oral cavities of all study subjects, their human and animal companions, and household water sources were sampled. Pulsed field gel electrophoresis was used to estimate clonal relatedness of P. aeruginosa isolates. RESULTS: In a multivariate model, visiting a dog park was associated with 77% increased odds of case status (P = 0.048). Strains clonal to the infection isolates were obtained from subjects' mouths (n = 18), companion pets' mouths (n = 5), pet owners' mouths (n = 2), water bowls (n = 7) and water taps (n = 2). Clonally related P. aeruginosa isolates were obtained from dogs that had no clear epidemiological link. CONCLUSIONS AND CLINICAL IMPORTANCE: Genetic homology between otic and environmental isolates is consistent with a waterborne source for some dogs, and cross-contamination with other human and animal members within some households.
[Mh] Termos MeSH primário: Doenças do Cão/microbiologia
Otite/veterinária
Infecções por Pseudomonas/veterinária
Pseudomonas aeruginosa/genética
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Doenças do Cão/epidemiologia
Cães
Eletroforese em Gel de Campo Pulsado/veterinária
Seres Humanos
Masculino
Otite/epidemiologia
Otite/microbiologia
Estudos Prospectivos
Infecções por Pseudomonas/epidemiologia
Infecções por Pseudomonas/microbiologia
Pseudomonas aeruginosa/isolamento & purificação
Fatores de Risco
Zoonoses/epidemiologia
Zoonoses/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1111/vde.12347


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[PMID]:27481884
[Au] Autor:Torretta S; Marchisio P; Rinaldi V; Gaffuri M; Pascariello C; Drago L; Baggi E; Pignataro L
[Ad] Endereço:Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy sara.torretta@gmail.com.
[Ti] Título:Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations.
[So] Source:Int J Immunopathol Pharmacol;29(3):438-42, 2016 Sep.
[Is] ISSN:2058-7384
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hyaluronic acid (HA) treatment has been successfully performed in patients with recurrent upper airway infections or rhinitis. The aim of this study was to assess the efficacy and safety of the topical nasal administration of an HA-based compound by investigating its effects in children with recurrent or chronic middle ear inflammations and chronic adenoiditis. A prospective, single-blind, 1:1 randomised controlled study was performed to compare otoscopy, tympanometry and pure-tone audiometry in children which received the daily topical administration of normal 0.9% sodium chloride saline solution (control group) or 9 mg of sodium hyaluronate in 3 mL of a 0.9% sodium saline solution. The final analysis was based on 116 children (49.1% boys; mean age, 62.9 ± 17.9 months): 58 in the control group and 58 in the study group. At the end of follow-up, the prevalence of patients with impaired otoscopy was significantly lower in the study group (P value = 0.024) compared to baseline but not in the control group. In comparison with baseline, the prevalence of patients with impaired tympanometry at the end of the follow-up period was significantly lower in the study group (P value = 0.047) but not in the control group. The reduction in the prevalence of patients with conductive hearing loss (CHL) (P value = 0.008) and those with moderate CHL (P value = 0.048) was significant in the study group, but not in the control group. The mean auditory threshold had also significantly improved by the end of treatment in the study group (P value = 0.004) but not in the control group. Our findings confirm the safety of intermittent treatment with a topical nasal sodium hyaluronate solution and are the first to document its beneficial effect on clinical and audiological outcomes in children with recurrent or chronic middle ear inflammations associated with chronic adenoiditis.
[Mh] Termos MeSH primário: Doença Crônica/tratamento farmacológico
Ácido Hialurônico/administração & dosagem
Otite/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Intranasal
Administração Tópica
Audiometria de Tons Puros/métodos
Limiar Auditivo/efeitos dos fármacos
Estudos de Casos e Controles
Pré-Escolar
Feminino
Seres Humanos
Masculino
Estudos Prospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
9004-61-9 (Hyaluronic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1177/0394632016656012



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