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[PMID]:29400027
[Au] Autor:Montava M; Curto CL; Mancini J; Collin M; Lavieille JP
[Ti] Título:[Comparison of stapes protheses: A prospective analysis of audiometric results obtained after stapedotomy by implantation of a teflon piston and a Soft-CliP® piston].
[So] Source:Rev Laryngol Otol Rhinol (Bord);136(3):97-102, 2015.
[Is] ISSN:0035-1334
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:A wide variety of pistons are available for stapes surgery in otosclerosis. The objective of this work was to analyze the short-term and medium-term results of Soft-CliP® piston in prima­ry stapes surgery and to compare it with a conventional prosthesis. The study was prospective, monocentric, rando­mi­zed, based on efficiency of Soft-CliP® prosthesis (11 patients) versus Causse® Teflon prosthesis (9 patients) in otosclerosis surgery. Epidemiological data, treatment modalities, pure-tone audiometric results and outcome of patients were studied. Mean follow-up was 10 months. Soft-CliP® placement was statisti­cally longer. The mean postoperative air-bone gap was within 10 dB in 73% and 67% of cases at 2 months and in 82% and 89% of cases at medium-term in Soft-CliP® and Teflon groups respectively. A statistically significant decrease in mean air-bone gap and for all frequencies was observed at 2 months and at medium term, with no difference between the 2 groups. The main result was the demonstration of the reliability and safety of Soft-CliP® prosthesis. With a new design, Soft-CliP® place­ment was easy. The biomechanics of ossicular chain should be better preserved, and the risk of incus erosion and necrosis decreased. A study on a larger population in the long-term would validate these results.
[Mh] Termos MeSH primário: Audiometria
Prótese Ossicular
Otosclerose/cirurgia
Cirurgia do Estribo
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Desenho de Prótese
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE


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[PMID]:29298506
[Au] Autor:Malafronte G
[Ad] Endereço:1 S.G. Moscati Hospital Company of National Importance, Avellino, Italy.
[Ti] Título:A New Reversal Steps Stapedotomy.
[So] Source:Ann Otol Rhinol Laryngol;127(3):167-170, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate whether removal of the stapes head and not the entire stapes superstructure prevents footplate complications. STUDY DESIGN: Prospective study. PATIENTS: One hundred and forty-five patients with otosclerosis were included. Patients were divided into 2 groups as follows: Individuals in group 1 (n = 75) underwent removal of the entire stapes superstructure; individuals in group 2 (n = 70) underwent removal of the stapes head only. These 2 groups were further subdivided into 2 subgroups based on the type of otosclerosis. Group 1a included 55 cases of marginal otosclerosis, while group 1b included 15 diffusive and 5 biscuit otosclerosis cases. Group 2a included 51 marginal otosclerosis cases, while group 2b included 14 diffuse and 5 biscuit otosclerosis cases. Estimations were made regarding statistical correlation between type of reversal steps stapedotomy, otosclerosis type, incidence of footplate complications, and hearing results. RESULTS: There were 9 footplate complications in group 1b and no complications in group 2b. This difference was significant. Air-bone gap closure to within 10 dB was achieved in 65% of cases in group 1b and 94.7% in group 2b. This difference was significant. CONCLUSION: The new stapedotomy prevented footplate complications and improved hearing results in diffuse and biscuit otosclerosis.
[Mh] Termos MeSH primário: Otosclerose
Complicações Pós-Operatórias
Cirurgia do Estribo
Estribo/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Perda Auditiva Condutiva/diagnóstico
Perda Auditiva Condutiva/etiologia
Perda Auditiva Condutiva/cirurgia
Testes Auditivos/métodos
Seres Humanos
Itália
Masculino
Meia-Idade
Otosclerose/diagnóstico
Otosclerose/cirurgia
Avaliação de Processos e Resultados (Cuidados de Saúde)
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/prevenção & controle
Cirurgia do Estribo/efeitos adversos
Cirurgia do Estribo/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417751156


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[PMID]:28542633
[Au] Autor:Kwacz M; Solyga M; Mrówka M; Kamieniecki K
[Ad] Endereço:Warsaw University of Technology, Institute of Micromechanics and Photonics, Warsaw, Poland.
[Ti] Título:New chamber stapes prosthesis - A preliminary assessment of the functioning of the prototype.
[So] Source:PLoS One;12(5):e0178133, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Piston-stapedotomy is the most common method for hearing restoration in patients with otosclerosis. In this study, we have experimentally examined a prototype of a new chamber stapes prosthesis. The prototype was implanted in a human cadaver temporal bone. The round window vibrations before and after implantation were measured for the acoustic signal (90 dB SPL, 0.8-8 kHz) in the external auditory canal. In comparison with a 0.4-mm piston prosthesis, the chamber prosthesis induced significantly higher vibration of the round window, especially for frequencies above 1.5 kHz. Based on the results, it can be surmised that stapedotomy with a chamber stapes prosthesis could provide better hearing results in comparison with the piston-stapedotomy.
[Mh] Termos MeSH primário: Prótese Ossicular
[Mh] Termos MeSH secundário: Estimulação Acústica
Cadáver
Desenho de Equipamento
Seres Humanos
Lactonas
Otosclerose/fisiopatologia
Otosclerose/cirurgia
Janela da Cóclea/fisiopatologia
Janela da Cóclea/cirurgia
Cirurgia do Estribo/instrumentação
Cirurgia do Estribo/métodos
Osso Temporal/fisiopatologia
Osso Temporal/cirurgia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lactones); 0 (vibralactone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178133


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[PMID]:28485298
[Au] Autor:Czerwinska G; Scierski W; Namyslowski G; Lisowska G; Misiolek M
[Ad] Endereço:Katedra i Oddzial Kliniczny Laryngologii w Zabrzu, SUM w Katowicach, Poland Kierownik: G. Namyslowski.
[Ti] Título:The surgical treatment results of otosclerosis at the Department of Otolaryngology Silesian Medical University in Zabrze in years 2000-2010.
[So] Source:Otolaryngol Pol;71(2):16-21, 2017 Apr 30.
[Is] ISSN:2300-8423
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Otosclerosis is a cause of 5-9% of all hearing loss. The most effective treatment of otoslerosis is stapedotomy. AIM: The aim of this study was to evaluate the results of otosclerosis surgical treatment and to examine the impact of disease stage, time of the signs, age and sex on the results. MATERIAL AND METHODS: 105 patients who underwent operation due to otosclerosis at the Department of Otolaryngology University Hospital in Zabrze at the age of 18-65 were analyzed. In 25 patients stapedotomy was bilateral. 130 cases of treated ears were included in the statistical analysis. The state of hearing after operation was evaluated with regard to guidance of Hearing and Balance Committee of American Academy of Otolaryngology - Head and Neck Surgery and with consideration of suggestions made by European Academy of Otolaryngology and Neurootology. Mean values of bone and air conduction, air bone gap before, one year after treatment, and at least 4 years after surgery were compared. The influence of stage of the disease in terms of Shambaugh index, lasting of signs, age and sex were evaluated with regard to change of mean hearing loss according to Bell Telephone Laboratories. RESULTS: On the basis of hearing examination evaluating improvement in air and bone conduction and reduction of cochlear reserve, very good and good treatment results were obtained in over 90% of patients in short and long term observations. No influence of disease stage, time of signs lasting, age and sex on the results of treatment - with regard to change in mean hearing loss was shown.
[Mh] Termos MeSH primário: Perda Auditiva Condutiva/cirurgia
Otosclerose/cirurgia
Cirurgia do Estribo/métodos
[Mh] Termos MeSH secundário: Adulto
Percepção Auditiva
Condução Óssea
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Polônia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.5604/01.3001.0009.8410


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[PMID]:28318477
[Au] Autor:Kanona H; Rana I; Offiah C; Patel N
[Ad] Endereço:Department of Otolaryngology,Whipps Cross University Hospital,London,UK.
[Ti] Título:Importance of a dedicated neuroradiologist in reporting high-resolution computed tomography for otosclerosis: a retrospective comparison study of 40 patients.
[So] Source:J Laryngol Otol;131(6):492-496, 2017 Jun.
[Is] ISSN:1748-5460
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study aimed to compare the reporting of high-resolution computed tomography of temporal bones for otosclerosis by general radiologists and a neuroradiologist within a local National Health Service Trust. METHODS: A retrospective case review of 36 high-resolution temporal bone computed tomography images obtained between 2008 and 2015 from 40 otosclerosis patients (surgically confirmed) was performed in a district general hospital setting. The main outcome measures were correct identification of otosclerosis by high-resolution computed tomography and adherence to the petrous temporal bone imaging protocol. RESULTS: Correct diagnosis rates were significantly different when made by general radiologists vs a neuroradiologist (p < 0.0001; two-tailed Fisher's exact test). None of the high-resolution computed tomography scans adhered to the temporal bone imaging protocol. CONCLUSION: The use of high-resolution computed tomography for suspected otosclerosis is helpful for diagnosis, disease staging, obtaining informed consent, surgical planning and prognosis. This study suggests that radiological detection of otosclerotic changes by high-resolution computed tomography of the temporal bone is significantly better when performed by a dedicated neuroradiologist than by a general radiologist. Use of a standardised temporal bone computed tomography protocol is recommended to provide consistently high-quality images for maximising disease detection.
[Mh] Termos MeSH primário: Erros de Diagnóstico/estatística & dados numéricos
Neurorradiografia/métodos
Otosclerose/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Fidelidade a Diretrizes
Seres Humanos
Masculino
Meia-Idade
Neurologistas
Neurorradiografia/normas
Otosclerose/cirurgia
Osso Petroso/diagnóstico por imagem
Radiologistas
Estudos Retrospectivos
Osso Temporal/diagnóstico por imagem
Tomografia Computadorizada por Raios X/normas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1017/S0022215117000561


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[PMID]:28252592
[Au] Autor:Vishnyakov VV; Svistushkin VM; Sin'kov EV
[Ad] Endereço:V.M. Evdokimov Moscow State Medical Stomatological University, Moscow, Russia, 127473.
[Ti] Título:[The application of the modern high-energy laser technologies for the surgical treatment of the patients presenting with otosclerosis].
[Ti] Título:Sovremennye vysokoénergeticheskie lazernye tekhnologii pri khirurgicheskom lechenii bol'nykh otosklerozom..
[So] Source:Vestn Otorinolaringol;82(1):56-58, 2017.
[Is] ISSN:0042-4668
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The objective of the present study was to determine the optimal parameters of radiation of the CO2 laser during the surgical intervention for the treatment of the patients presenting with otosclerosis. The experimental part of the study was carried out with the use of the isolated temporal bones. Under the clinical conditions, the patients with the tympanic and mixed forms of otosclerosis underwent stapedoplasty with the use of the CO2 laser. It was shown that the use of the CO2 laser at different stages of stapedoplasty considerably reduces the risk of development of the post-operative complications. It is concluded that the proposed stapedoplastic technique makes it possible to decrease the duration of post-surgical rehabilitation of the patients suffering from otosclerosis.
[Mh] Termos MeSH primário: Terapia a Laser/métodos
Otosclerose/cirurgia
Avaliação de Processos e Resultados (Cuidados de Saúde)
Cirurgia do Estribo/métodos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.17116/otorino201782156-58


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[PMID]:28151457
[Au] Autor:Alzhrani F; Mokhatrish MM; Al-Momani MO; Alshehri H; Hagr A; Garadat SN
[Ti] Título:Effectiveness of stapedotomy in improving hearing sensitivity for 53 otosclerotic patients: retrospective review.
[So] Source:Ann Saudi Med;37(1):49-55, 2017 Jan-Feb.
[Is] ISSN:0975-4466
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Otosclerosis is a common cause of progressive hearing impairment that causes fixation of the stapes. Surgical intervention is the preferred treatment approach to ameliorate the conductive hearing loss associated with stapedial otosclerosis. However, given that it is a difficult and delicate procedure, the surgery may fail for a number of reasons. Therefore, it is very important to evaluate the success rate of the surgical approach used in each regional center. OBJECTIVE: To examine the effectiveness of stapedotomy in improving hearing sensitivity for otosclerotic patients at King Abdul Aziz University Hospital in Riyadh. DESIGN: Retrospective chart review with an analysis of pre- and postoperative surgical treatment. SETTING: Tertiary referral otolaryngology clinic. PATIENTS AND METHODS: All cases who underwent stapedotomy between 1997 and 2009 were retrospectively reviewed. Preoperative and postoperative audiometric assessments were conducted using conventional pure tone audiometry. Differences were analyzed by two-way repeated measures ANOVA. MAIN OUTCOME MEASURE(S): Pre- and postoperative pure tone thresholds for air and bone conduction. RESULT: Fifty-three patients underwent stapedotomy. Stapedotomy yielded significant improvements in mean (SD) postoperative air-conduction thresholds of about 18.7 (11.7) dB (P < .0001) and mean (SD) post.operative bone-conduction thresholds of about 2 (7.2) dB (P < .05). Additionally, a significant correlation was found between improvement in air-conduction thresholds and the size of preoperatve air-bone gap (P < .01) About 70%of patients achieved an air-bone gap of 20 dB or better. None of the cases examined in this study exhibited sensorineural hearing loss or adverse complications following stapedotomy. CONCLUSIONS: Stapedotomy is a safe and effective treatment option for patients with otosclerosis. Given that the majority of participants in this study exhibited mixed hearing loss preoperatively, the results further suggest that stapedotomy can also be effective in improving thresholds for these patients. LIMITATIONS: The sample size was relatively small.
[Mh] Termos MeSH primário: Perda Auditiva Condutiva/cirurgia
Otosclerose/cirurgia
Cirurgia do Estribo/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Audiometria de Tons Puros
Condução Óssea
Feminino
Audição
Perda Auditiva Condutiva/etiologia
Perda Auditiva Condutiva/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Otosclerose/complicações
Otosclerose/fisiopatologia
Período Pós-Operatório
Estudos Retrospectivos
Estribo/fisiopatologia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.5144/0256-4947.2017.49


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[PMID]:28090791
[Au] Autor:Yamashita K; Hiwatashi A; Togao O; Kondo M; Kikuchi K; Inoguchi T; Maehara J; Kyuragi Y; Honda H
[Ad] Endereço:1 Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:Additive value of "otosclerosis-weighted" images for the CT diagnosis of fenestral otosclerosis.
[So] Source:Acta Radiol;58(10):1215-1221, 2017 Oct.
[Is] ISSN:1600-0455
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background Otosclerotic foci are usually seen as minute low-density lesions and this may be attributed to relatively low sensitivity on visual assessment using computed tomography (CT). Otosclerotic foci can be detected by using the accurate region of interest (ROI) setting, while small ROI settings by less-experienced radiologists may result in false negative findings. Purpose To evaluate the diagnostic ability of our proposed method ("otosclerosis-weighted" imaging [OWI]), which is based on reversing the density, compared with conventional CT (CCT) imaging alone. Material and Methods Temporal bone CTs of consecutive patients with otosclerosis were analyzed. Gender- and age-matched control participants were also included. All CT images were obtained using a 64-detector row scanner. OWI was obtained by extracting the temporal bone region using the threshold technique and reversing the density (black to white). Four independent radiologists took part in two reading sessions. In the first session, the observers read only CCT imaging. In the second session, they read OWI along with the CCT imaging. Sensitivity was assessed for the four readers. Results Thirty temporal bones of 25 patients with otosclerosis (3 men, 22 women; mean age, 53.9 ± 9.0 years) and 30 temporal bones of 30 control participants (4 men, 26 women; mean age, 44.0 ± 16.2 years) were included. For all observers, reading with a combination of the two methods was associated with a higher sensitivity (63.3-80.0%) than with conventional CT images alone (30.0-60.0%; P < 0.05, each). Conclusion Application of our proposed method based on threshold value may help detect foci of fenestral otosclerosis.
[Mh] Termos MeSH primário: Otosclerose/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Osso Temporal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1177/0284185116687172


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[PMID]:28068300
[Au] Autor:Vandevoorde A; Williams MT; Ukkola-Pons E; Daval M; Ayache D
[Ad] Endereço:*Department of Otolaryngology, Head and Neck Surgery†Department of Medical Imaging, Fondation A. de Rothschild, Paris, France.
[Ti] Título:Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome.
[So] Source:Otol Neurotol;38(2):168-172, 2017 Feb.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sensorineural complications of stapes surgery are rare but potentially serious. Imaging is usually performed to identify an underlying cause, such as excessive intravestibular penetration of the prosthesis or pneumolabyrinth suggesting perilymphatic fistula. Unfortunately, there is very little data in an unselected series of uneventful patients.The aim of this study was to analyze the depth of prosthesis penetration within the vestibule and the rate of pneumolabyrinth the day or the day after the procedure by performing a cone beam computed tomography of the temporal bone in a cohort of unselected patients, and to correlate imaging findings to clinical outcome. METHODS: A prospective monocentric study was conducted in a tertiary referral medical center. A cone beam computed tomography was performed in 80 consecutive patients having undergone stapes surgery for otosclerosis, the day or the day after the procedure. Penetration length and location of the prosthesis within the vestibule, as well as presence or absence of a pneumolabyrinth, were recorded, and compared with clinical data (vertigo, nystagmus, hearing measurement). RESULTS: Pneumolabyrinth was found in 15% of the patients. The mean penetration length of the prosthesis within the vestibule was 1 mm (0-1.9 mm). No serious complication occurred during the study period. No correlations were found when comparing imaging findings to clinical outcome. CONCLUSION: Our results do not support empirically insights into detrimental effects of postoperative pneumolabyrinth or too long prosthesis after stapes surgery. Further studies are needed to better understand the causes of postoperative complications of stapes surgery.
[Mh] Termos MeSH primário: Tomografia Computadorizada de Feixe Cônico
Audição
Otosclerose/diagnóstico por imagem
Cirurgia do Estribo/efeitos adversos
Osso Temporal/diagnóstico por imagem
Vestíbulo do Labirinto/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Nistagmo Patológico/diagnóstico por imagem
Nistagmo Patológico/etiologia
Otosclerose/cirurgia
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/etiologia
Período Pós-Operatório
Estudos Prospectivos
Osso Temporal/cirurgia
Resultado do Tratamento
Vertigem/diagnóstico por imagem
Vertigem/etiologia
Vestíbulo do Labirinto/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001306


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[PMID]:27851656
[Au] Autor:Kaya S; Paparella MM; Cureoglu S
[Ad] Endereço:*Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, U.S.A. †Department of Otolaryngology-Head and Neck Surgery, Gebze Fatih State Hospital, Gebze, Kocaeli, Turkey ‡Paparella Ear Head & Neck Institute, Minneapolis, Minnesota, U.S.A.
[Ti] Título:Does Otosclerosis Affect Dark and Transitional Cells in the Human Vestibular Labyrinth?
[So] Source:Otol Neurotol;38(2):234-238, 2017 Feb.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HYPOTHESIS: The density of vestibular dark cells (DCs) and vestibular transitional cells (TCs) can be quantitatively decreased in human temporal bones with otosclerosis. BACKGROUND: Previous reports have shown that otosclerosis can lead to vestibular symptoms. METHODS: We examined 61 human temporal bone specimens from 52 deceased donors with otosclerosis group-with and without endosteal involvement (EI), and with and without endolymphatic hydrops (EH)-versus 25 specimens from 18 age-matched controls. Using light microscopy, we evaluated the nonsensory epithelium of the lateral semicircular canal (LSC) and posterior semicircular canal (PSC) of the human vestibular labyrinth, focusing on the density of DCs and TCs. RESULTS: In both the LSC and the PSC, as compared with the control group, the mean density of DCs significantly decreased in the EI (+) group, in the EI (+) and EH (+) subgroup, and in the EI (+) and EH (-) subgroup (p < 0.05). In addition, we found a significant difference in the mean density of DCs between the EI (+) group and the EI (-) group in the LSC and in the PSC (p < 0.05). But we found no significant difference in the mean density of TCs in any of the otosclerosis groups or subgroups as compared with the control group (p > 0.05). CONCLUSION: We found a decrease in the density of DCs associated with EI in human temporal bone specimens with otosclerosis, regardless of the presence of EH. This decrease might cause damage in ion and water transportation, leading to vestibular symptoms.
[Mh] Termos MeSH primário: Otosclerose/complicações
Vestíbulo do Labirinto/patologia
[Mh] Termos MeSH secundário: Adulto
Células Epiteliais/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Osso Temporal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000001272



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