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[PMID]:27257624
[Au] Autor:Anttonen T; Herranen A; Virkkala J; Kirjavainen A; Elomaa P; Laos M; Liang X; Ylikoski J; Behrens A; Pirvola U
[Ad] Endereço:Department of Biosciences, University of Helsinki , 00014 Helsinki, Finland.
[Ti] Título:c-Jun N-Terminal Phosphorylation: Biomarker for Cellular Stress Rather than Cell Death in the Injured Cochlea.
[So] Source:eNeuro;3(2), 2016 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prevention of auditory hair cell death offers therapeutic potential to rescue hearing. Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with unsolved mechanisms. We have characterized the c-Jun stress response in the mouse cochlea challenged with acoustic overstimulation and ototoxins, by studying the dynamics of c-Jun N-terminal phosphorylation. It occurred acutely in glial-like supporting cells, inner hair cells, and the cells of the cochlear ion trafficking route, and was rapidly downregulated after exposures. Notably, death-prone outer hair cells lacked c-Jun phosphorylation. As phosphorylation was triggered also by nontraumatic noise levels and none of the cells showing this activation were lost, c-Jun phosphorylation is a biomarker for cochlear stress rather than an indicator of a death-prone fate of hair cells. Preconditioning with a mild noise exposure before a stronger traumatizing noise exposure attenuated the cochlear c-Jun stress response, suggesting that the known protective effect of sound preconditioning on hearing is linked to suppression of c-Jun activation. Finally, mice with mutations in the c-Jun N-terminal phosphoacceptor sites showed partial, but significant, hair cell protection. These data identify the c-Jun stress response as a paracrine mechanism that mediates outer hair cell death.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Células Ciliadas Vestibulares/metabolismo
Perda Auditiva Provocada por Ruído/patologia
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Traumatismos do Nervo Vestibulococlear/patologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Apoptose
Morte Celular/efeitos dos fármacos
Morte Celular/fisiologia
Proteínas de Ligação a DNA/genética
Proteínas de Ligação a DNA/metabolismo
Modelos Animais de Doenças
Feminino
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Canamicina/toxicidade
Masculino
Camundongos
Camundongos Endogâmicos CBA
Camundongos Transgênicos
Ruído/efeitos adversos
Inibidores da Síntese de Proteínas/toxicidade
Fatores de Tempo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Traumatismos do Nervo Vestibulococlear/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (DNA-Binding Proteins); 0 (Gfi1 protein, mouse); 0 (Protein Synthesis Inhibitors); 0 (Transcription Factors); 147336-22-9 (Green Fluorescent Proteins); 59-01-8 (Kanamycin); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE


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[PMID]:25280052
[Au] Autor:Iseli CE; Merwin WH; Klatt-Cromwell C; Hutson KA; Ewend MG; Adunka OF; Fitzpatrick DC; Buchman CA
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, U.S.A.
[Ti] Título:Effect of cochlear nerve electrocautery on the adult cochlear nucleus.
[So] Source:Otol Neurotol;36(4):670-7, 2015 Apr.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:HYPOTHESIS: Electrocauterization and subsequent transection of the cochlear nerve induce greater injury to the cochlear nucleus than sharp transection alone. BACKGROUND: Some studies show that neurofibromatosis Type 2 (NF2) patients fit with auditory brainstem implants (ABIs) fail to achieve speech perception abilities similar to ABI recipients without NF2. Reasons for these differences remain speculative. One hypothesis posits poorer performance to surgically induced trauma to the cochlear nucleus from electrocautery. Sustained electrosurgical depolarization of the cochlear nerve may cause excitotoxic-induced postsynaptic nuclear injury. Equally plausible is that cautery in the vicinity of the cochlear nucleus induces necrosis. METHODS: The cochlear nerve was transected in anesthetized adult gerbils sharply with or without bipolar electrocautery at varying intensities. Gerbils were perfused at 1, 3, 5, and 7 days postoperatively; their brainstem and cochleas were embedded in paraffin and sectioned at 10 µm. Alternate sections were stained with flourescent markers for neuronal injury or Nissl substance. In additional experiments, anterograde tracers were applied directly to a sectioned eighth nerve to verify that fluorescent-labeled profiles seen were terminating auditory nerve fibers. RESULTS: Cochlear nerve injury was observed from 72 hours postoperatively and was identical across cases regardless of surgical technique. Postsynaptic cochlear nucleus injury was not seen after distal transection of the nerve. By contrast, proximal transection was associated with trauma to the cochlear nucleus. CONCLUSION: Distal application of bipolar electrocautery seems safe for the cochlear nucleus. Application near the root entry zone must be used cautiously because this may compromise nuclear viability needed to support ABI stimulation.
[Mh] Termos MeSH primário: Implante Auditivo de Tronco Encefálico
Nervo Coclear/cirurgia
Núcleo Coclear/patologia
Eletrocoagulação/efeitos adversos
Eletrocoagulação/métodos
Traumatismos do Nervo Vestibulococlear/complicações
[Mh] Termos MeSH secundário: Animais
Implante Auditivo de Tronco Encefálico/efeitos adversos
Implante Auditivo de Tronco Encefálico/métodos
Implantes Auditivos de Tronco Encefálico
Nervo Coclear/lesões
Modelos Animais de Doenças
Gerbillinae
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150313
[Lr] Data última revisão:
150313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141004
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0000000000000588


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[PMID]:24306235
[Au] Autor:Ying T; Thirumala P; Chang Y; Habeych M; Crammond D; Balzer J
[Ad] Endereço:Department of Neurological Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
[Ti] Título:Emprical factors associated with Brainstem auditory evoked potential monitoring during microvascular decompression for hemifacial spasm and its correlation to hearing loss.
[So] Source:Acta Neurochir (Wien);156(3):571-5, 2014 Mar.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cranial nerve VIII is at risk during microvascular decompression (MVD) for hemifacial spasm (HFS). The primary aim of this study is to evaluate the empirical factors associated with brainstem auditory evoked potential monitoring and its correlation to post operative hearing loss (HL) after MVD for HFS. METHODS: Pre-operative and post-operative audiogram data and BAEP from ninety-four patients who underwent MVD for HFS were analyzed. Pure tone audiometry (PTA) and Speech Discrimination Score (SDS) were performed on all patients before and after surgery. Intraoperative neurophysiological data were reviewed independently. HL was assessed using the AAO-HNS classification system for non-serviceable hearing loss (Class C/D), defined as PTA >50 dB and/or SDS <50% within the speech range of frequencies. RESULTS: Patients with HL had higher rates of loss in the amplitude of wave V and prolongation in the interpeak latency of peak I-V latency during MVD. Gender, age, side, and MVD duration did not increase the risk of HL. There was no correlation between successive number of BAEP changes (reflective of the number of surgical attempts) and HL. There was no association between the speed of recovery of BAEPs and HL. CONCLUSIONS: Patients with new post-operative HL have a faster rate of change in the amplitude of wave V and the interpeak I-V latency during intraoperative BAEP monitoring for HFS. Our alarm criteria to inform the surgeon about impending nerve injury might have to be modified and prospectively tested to prevent rapid change in BAEPs.
[Mh] Termos MeSH primário: Potenciais Evocados Auditivos do Tronco Encefálico
Perda Auditiva/prevenção & controle
Espasmo Hemifacial/cirurgia
Cirurgia de Descompressão Microvascular/métodos
Monitorização Intraoperatória/métodos
Traumatismos do Nervo Vestibulococlear/diagnóstico
Traumatismos do Nervo Vestibulococlear/prevenção & controle
[Mh] Termos MeSH secundário: Audiometria de Tons Puros
Surdez/diagnóstico
Surdez/prevenção & controle
Feminino
Perda Auditiva/diagnóstico
Seres Humanos
Complicações Intraoperatórias/diagnóstico
Complicações Intraoperatórias/etiologia
Complicações Intraoperatórias/prevenção & controle
Masculino
Cirurgia de Descompressão Microvascular/efeitos adversos
Meia-Idade
Estudos Retrospectivos
Traumatismos do Nervo Vestibulococlear/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140213
[Lr] Data última revisão:
140213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131206
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-013-1957-9


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[PMID]:24113829
[Au] Autor:Yuan Y; Shi F; Yin Y; Tong M; Lang H; Polley DB; Liberman MC; Edge AS
[Ad] Endereço:Department of Otology and Laryngology, Harvard Medical School, Boston, MA, 02115, USA.
[Ti] Título:Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy.
[So] Source:J Assoc Res Otolaryngol;15(1):31-43, 2014 Feb.
[Is] ISSN:1438-7573
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ouabain application to the round window can selectively destroy type-I spiral ganglion cells, producing an animal model of auditory neuropathy. To assess the long-term effects of this deafferentation on synaptic organization in the organ of Corti and cochlear nucleus, and to ask whether surviving cochlear neurons show any post-injury plasticity in the adult, we quantified the peripheral and central synapses of type-I neurons at posttreatment times ranging from 1 to 3 months. Measures of normal DPOAEs and greatly reduced auditory brainstem responses (ABRs) confirmed the neuropathy phenotype. Counts of presynaptic ribbons and postsynaptic glutamate receptor patches in the inner hair cell area decreased with post-exposure time, as did counts of cochlear nerve terminals in the cochlear nucleus. Although these counts provided no evidence of new synapse formation via branching from surviving neurons, the regular appearance of ectopic neurons in the inner hair cell area suggested that neurite extension is not uncommon. Correlations between pathophysiology and histopathology showed that ABR thresholds are very insensitive to even massive neural degeneration, whereas the amplitude of ABR wave 1 is a better metric of synaptic degeneration.
[Mh] Termos MeSH primário: Nervo Coclear/patologia
Degeneração Neural/induzido quimicamente
Plasticidade Neuronal/efeitos dos fármacos
Ouabaína/efeitos adversos
Ouabaína/farmacologia
Sinapses/efeitos dos fármacos
Traumatismos do Nervo Vestibulococlear/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Cóclea/efeitos dos fármacos
Cóclea/inervação
Cóclea/fisiopatologia
Nervo Coclear/efeitos dos fármacos
Modelos Animais de Doenças
Inibidores Enzimáticos/efeitos adversos
Inibidores Enzimáticos/farmacologia
Feminino
Camundongos
Camundongos Endogâmicos CBA
Degeneração Neural/patologia
Degeneração Neural/fisiopatologia
Órgão Espiral/patologia
Órgão Espiral/fisiopatologia
Terminações Pré-Sinápticas/efeitos dos fármacos
Terminações Pré-Sinápticas/parasitologia
Receptores de Glutamato/efeitos dos fármacos
Receptores de Glutamato/fisiologia
Sinapses/patologia
Fatores de Tempo
Traumatismos do Nervo Vestibulococlear/patologia
Traumatismos do Nervo Vestibulococlear/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Receptors, Glutamate); 5ACL011P69 (Ouabain)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131012
[St] Status:MEDLINE
[do] DOI:10.1007/s10162-013-0419-7


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[PMID]:23451756
[Au] Autor:Thirumala PD; Ilangovan P; Habeych M; Crammond DJ; Balzer J
[Ad] Endereço:Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. thirumalapd@upmc.edu
[Ti] Título:Analysis of interpeak latencies of brainstem auditory evoked potential waveforms during microvascular decompression of cranial nerve VII for hemifacial spasm.
[So] Source:Neurosurg Focus;34(3):E6, 2013 Mar.
[Is] ISSN:1092-0684
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECT: Microvascular decompression (MVD) of the facial nerve is an effective treatment for patients with hemifacial spasm. Intraoperative monitoring of brainstem auditory evoked potentials (BAEPs) during MVD can reduce the incidence of hearing loss. In this study the authors' goal was to evaluate changes in interpeak latencies (IPLs) of Waves I-V, Waves III-V, and Waves I-III of BAEP Waveforms I, III, and V during MVD and correlate them with postoperative hearing loss. To date, no such study has been performed. Hearing loss is defined as nonuseful hearing (Class C/D), which is a pure tone average of more than 50 dB and/or speech discrimination score of less than 50%. METHODS: The authors performed a retrospective analysis of IPLs of BAEPs in 93 patients who underwent intraoperative BAEP monitoring during MVD. Patients who did not have hearing loss were in Class A/B and those who had hearing loss were in Class C/D. RESULTS: Binary logistic regression analysis of independent IPL variables was performed. A maximum change in IPLs of Waves I-III and Waves I-V and on-skin change in IPLs of Waves I-V increases the odds of hearing loss. However, on adjusting the same variables for loss of response, change in IPLs did not increase the odds of hearing loss. CONCLUSIONS: Changes in IPL measurements did not increase the odds of postoperative hearing loss. This information might be helpful in evaluating the value of IPLs as alarm criteria during MVD to prevent hearing loss.
[Mh] Termos MeSH primário: Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia
Doenças do Nervo Facial/cirurgia
Perda Auditiva Neurossensorial/prevenção & controle
Espasmo Hemifacial/cirurgia
Complicações Intraoperatórias/prevenção & controle
Cirurgia de Descompressão Microvascular
Monitorização Intraoperatória/métodos
Síndromes de Compressão Nervosa/cirurgia
Traumatismos do Nervo Vestibulococlear/prevenção & controle
Nervo Vestibulococlear/fisiopatologia
[Mh] Termos MeSH secundário: Audiometria de Tons Puros
Eletromiografia
Nervo Facial/cirurgia
Doenças do Nervo Facial/complicações
Perda Auditiva Neurossensorial/diagnóstico
Perda Auditiva Neurossensorial/epidemiologia
Espasmo Hemifacial/etiologia
Seres Humanos
Incidência
Complicações Intraoperatórias/diagnóstico
Complicações Intraoperatórias/epidemiologia
Síndromes de Compressão Nervosa/complicações
Cuidados Pós-Operatórios
Valor Preditivo dos Testes
Cuidados Pré-Operatórios
Tempo de Reação
Estudos Retrospectivos
Traumatismos do Nervo Vestibulococlear/diagnóstico
Traumatismos do Nervo Vestibulococlear/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1308
[Cu] Atualização por classe:130304
[Lr] Data última revisão:
130304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130305
[St] Status:MEDLINE
[do] DOI:10.3171/2012.12.FOCUS12393


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[PMID]:22122955
[Au] Autor:Lindblad AC; Rosenhall U; Olofsson A; Hagerman B
[Ad] Endereço:Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. anncat.lindblad@ki.se
[Ti] Título:The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: a controlled trial.
[So] Source:Noise Health;13(55):392-401, 2011 Nov-Dec.
[Is] ISSN:1463-1741
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:In military outdoor shooting training, with safety measures enforced, the risk of a permanent, noise-induced hearing loss is very small. But urban warfare training performed indoors, with reflections from walls, might increase the risk. A question is whether antioxidants can reduce the negative effects of noise on human hearing as it does on research animals. Hearing tests were performed on a control group of 23 military officers before and after a shooting session in a bunker-like room. The experiments were repeated on another group of 11 officers with peroral adminstration of N-acetyl-cysteine (NAC), directly after the shooting. The measurements performed were tone thresholds; transient-evoked otoacoustic emissions, with and without contralateral noise; and psycho-acoustical modulation transfer function (PMTF), thresholds for brief tones in modulated noise. Effects from shooting on hearing thresholds were small, but threshold behavior supports use of NAC treatment. On the PMTF, shooting without NAC gave strong effects. Those effects were like those from continuous noise, which means that strict safety measures should be enforced. The most striking finding was that the non-linearity of the cochlea, that was strongly reduced in the group without NAC, as manifested by the PMTF-results, was practically unchanged in the NAC-group throughout the study. NAC treatment directly after shooting in a bunkerlike room seems to give some protection of the cochlea.
[Mh] Termos MeSH primário: Acetilcisteína/uso terapêutico
Limiar Auditivo/efeitos dos fármacos
Perda Auditiva Provocada por Ruído/prevenção & controle
Traumatismos do Nervo Vestibulococlear/prevenção & controle
[Mh] Termos MeSH secundário: Acetilcisteína/farmacologia
Adulto
Análise de Variância
Audiometria
Estudos de Casos e Controles
Feminino
Depuradores de Radicais Livres/farmacologia
Depuradores de Radicais Livres/uso terapêutico
Perda Auditiva Provocada por Ruído/etiologia
Seres Humanos
Masculino
Meia-Idade
Militares
Estresse Oxidativo/efeitos dos fármacos
Estudos Prospectivos
Espécies Reativas de Oxigênio/efeitos adversos
Suécia
Traumatismos do Nervo Vestibulococlear/complicações
Traumatismos do Nervo Vestibulococlear/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0 (Reactive Oxygen Species); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1203
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111130
[St] Status:MEDLINE
[do] DOI:10.4103/1463-1741.90293


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[PMID]:21947792
[Au] Autor:Kilpatrick LA; Zhu J; Lee FS; Lang H
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA. kilpatri@musc.edu
[Ti] Título:Role of stromal cell-derived factor-1 expression in the injured mouse auditory nerve.
[So] Source:Otolaryngol Head Neck Surg;145(6):1007-15, 2011 Dec.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The degeneration of hair cells and spiral ganglion neurons (SGNs) is an important pathologic process in the development of sensorineural hearing loss. In a murine model, predictable and reproducible damage to SGNs occurs through the application of ouabain to the round window. Recent evidence has shown that the chemokine stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant of hematopoietic stem cells (HSCs) and provides trophic support to injured tissues during development and maturation. The hypothesis for the current study is that expression of SDF-1 plays an important role in protecting SGNs and preventing further degeneration in the setting of cochlear injury. STUDY DESIGN: Prospective, controlled. SETTING: Academic research laboratory. SUBJECT AND METHODS: Auditory brainstem response (ABR) and the expression of SDF-1 mRNA and protein were examined 1, 3, 7, 14, and 30 days after application of ouabain in 35 adult mice. RESULTS: Following ouabain application, real-time reverse-transcription polymerase chain reaction for SDF demonstrates increased mRNA expression following ouabain injury in nontransplanted mice. A significant increase in SDF protein expression was also observed using immunolabeling techniques and Western blot analysis. CONCLUSIONS: SDF-1 expression is increased in the auditory nerve following cochlear injury. Further knowledge about the cochlear microenvironment, including SDF-1, is critical to maximizing HSC engraftment in the injured cochlea and providing a therapeutic option for sensorineural hearing loss.
[Mh] Termos MeSH primário: Quimiocina CXCL12/metabolismo
Nervo Coclear/lesões
Perda Auditiva Neurossensorial/metabolismo
Traumatismos do Nervo Vestibulococlear/patologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Quimiocina CXCL12/genética
Nervo Coclear/patologia
Intervalos de Confiança
Modelos Animais de Doenças
Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia
Regulação da Expressão Gênica
Perda Auditiva Neurossensorial/patologia
Imuno-Histoquímica
Camundongos
Camundongos Endogâmicos CBA
Ouabaína/farmacologia
Distribuição Aleatória
Valores de Referência
Traumatismos do Nervo Vestibulococlear/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chemokine CXCL12); 5ACL011P69 (Ouabain)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110928
[St] Status:MEDLINE
[do] DOI:10.1177/0194599811416778


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[PMID]:21299996
[Au] Autor:Sindou M
[Ad] Endereço:Department of Neurosurgery, University of Lyon, France. marc.sindou@chu-lyon.fr
[Ti] Título:Operative strategies for minimizing hearing loss associated with microvascular decompression for trigeminal neuralgia.
[So] Source:World Neurosurg;74(1):111-2, 2010 Jul.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Descompressão Cirúrgica/métodos
Perda Auditiva Neurossensorial/prevenção & controle
Microcirurgia/métodos
Complicações Pós-Operatórias/prevenção & controle
Neuralgia do Trigêmeo/cirurgia
[Mh] Termos MeSH secundário: Artérias/cirurgia
Cerebelo/irrigação sanguínea
Descompressão Cirúrgica/efeitos adversos
Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia
Traumatismos do Nervo Facial/prevenção & controle
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem Tridimensional
Complicações Intraoperatórias/prevenção & controle
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Microcirurgia/efeitos adversos
Monitorização Intraoperatória/métodos
Complicações Pós-Operatórias/etiologia
Fatores de Risco
Traumatismos do Nervo Vestibulococlear
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Em] Mês de entrada:1103
[Cu] Atualização por classe:160519
[Lr] Data última revisão:
160519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110209
[St] Status:MEDLINE
[do] DOI:10.1016/j.wneu.2010.06.008


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[PMID]:20856161
[Au] Autor:Corrales CE; Monfared A; Jackler RK
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
[Ti] Título:Facial and vestibulocochlear nerve avulsion at the fundus of the internal auditory canal in a child without a temporal bone fracture.
[So] Source:Otol Neurotol;31(9):1508-10, 2010 Dec.
[Is] ISSN:1537-4505
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe a case of facial, vestibular, and cochlear nerve avulsion secondary to blunt trauma without an associated temporal bone fracture. STUDY DESIGN: Clinical capsule report. SETTING: University hospital. PATIENT: A 3.5-year-old girl presented with immediate facial nerve paralysis and complete deafness after being struck by an automobile. High-resolution computed tomography demonstrated a depressed occipital bone fracture with no visible fracture of the temporal bone. Magnetic resonance imaging sequence raised the question of VIIth nerve bundle discontinuity at the distal end of the internal auditory canal. INTERVENTION: The patient underwent a posterior fossa craniotomy via a translabyrinthine approach 9 months after the initial injury, and facial and auditory nerve avulsion at the fundus was confirmed at the time of surgery. The proximal segment of the facial nerve had formed a traumatic neuroma, which was resected, and primarily anastomosed to the rerouted distal segment. MAIN OUTCOME MEASURES: Facial nerve function. RESULTS: Patient has regained facial function to Grade III/VI House-Brackmann with no asymmetry at rest. CONCLUSION: An unusual pattern of injury is described. We suggest that in patients presenting with facial nerve paralysis secondary to blunt trauma, without an associated temporal bone fracture, high-resolution magnetic resonance imaging is recommended to evaluate internal auditory canal discontinuity of the VIIth and VIIIth nerve complexes. A potential mechanism of avulsion is explained.
[Mh] Termos MeSH primário: Orelha Interna/patologia
Nervo Facial/patologia
Osso Temporal/patologia
Nervo Vestibulococlear/patologia
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Audiometria
Pré-Escolar
Surdez/etiologia
Surdez/patologia
Doenças do Nervo Facial/etiologia
Doenças do Nervo Facial/patologia
Feminino
Seres Humanos
Procedimentos Cirúrgicos Otológicos
Tomografia Computadorizada por Raios X
Traumatismos do Nervo Vestibulococlear
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1103
[Cu] Atualização por classe:111117
[Lr] Data última revisão:
111117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100922
[St] Status:MEDLINE
[do] DOI:10.1097/MAO.0b013e3181f0c848


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[PMID]:19404569
[Au] Autor:Ozer FD; Duransoy YK; Camlar M
[Ad] Endereço:Department of Neurosurgery, Izmir Training and Research Hospital, Arikent Sitesi C-7 Blok D:9 Narlidere, 35360 Izmir, Turkey.
[Ti] Título:Atypic geniculate neuralgia: atypic anatomic correlation of cranial nerve roots and AICA.
[So] Source:Acta Neurochir (Wien);151(8):1003-4; discussion 1004, 2009 Aug.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Geniculate neuralgia is a rare cause of craniofacial pains. The anterior inferior cerebellar artery is the offending vessel which compress nervus intermedius in the patients with typical geniculate neuralgia. We report a patient whose pain was atypical for either geniculate neuralgia and trigeminal neuralgia. At operation the anterior inferior cerebellar artery was coursing with the nerves and was separated. After the decompression the pain resolved immediately.
[Mh] Termos MeSH primário: Artéria Basilar/patologia
Doenças do Nervo Facial/patologia
Nervo Facial/patologia
Dor Facial/patologia
Herpes Zoster da Orelha Externa/patologia
[Mh] Termos MeSH secundário: Adulto
Artéria Basilar/fisiopatologia
Artéria Basilar/cirurgia
Descompressão Cirúrgica/métodos
Nervo Facial/fisiopatologia
Nervo Facial/cirurgia
Doenças do Nervo Facial/etiologia
Doenças do Nervo Facial/fisiopatologia
Dor Facial/etiologia
Dor Facial/fisiopatologia
Feminino
Perda Auditiva Neurossensorial/etiologia
Herpes Zoster da Orelha Externa/etiologia
Herpes Zoster da Orelha Externa/fisiopatologia
Seres Humanos
Procedimentos Neurocirúrgicos/métodos
Complicações Pós-Operatórias/etiologia
Resultado do Tratamento
Procedimentos Cirúrgicos Vasculares/métodos
Vertigem/etiologia
Nervo Vestibulococlear/cirurgia
Traumatismos do Nervo Vestibulococlear
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:0910
[Cu] Atualização por classe:111117
[Lr] Data última revisão:
111117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090501
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-009-0367-5



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