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[PMID]:28460084
[Au] Autor:van der Meulen PM; Barendregt AM; Cuadrado E; Magro-Checa C; Steup-Beekman GM; Schonenberg-Meinema D; Van den Berg JM; Li QZ; Baars PA; Wouters D; Voskuyl AE; Ten Berge IRJM; Huizinga TWJ; Kuijpers TW
[Ad] Endereço:Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital Academic Medical Center.
[Ti] Título:Protein array autoantibody profiles to determine diagnostic markers for neuropsychiatric systemic lupus erythematosus.
[So] Source:Rheumatology (Oxford);56(8):1407-1416, 2017 Aug 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: The aim was to investigate the association between autoantibodies (autoAbs) and neuropsychiatric (NP) involvement in patients with SLE and to evaluate whether any autoAb or a combination of these autoAbs could indicate the underlying pathogenic process. Methods: Using a multiplexed protein array for 94 antigens, we compared the serum autoAb profiles of 69 NPSLE patients, 203 SLE patients without NP involvement (non-NPSLE) and 51 healthy controls. Furthermore, we compared the profiles of NPSLE patients with clinical inflammatory (n = 38) and ischaemic (n = 31) NP involvement. Results: In total, 75 IgG and 47 IgM autoAbs were associated with SLE patients in comparison with healthy controls. Comparing NPSLE with non-NPSLE and healthy control sera, 9 IgG (amyloid, cardiolipin, glycoprotein 2, glycoprotein 210, heparin, heparan sulphate, histone H2A, prothrombin protein and vimentin) and 12 IgM (amyloid, cardiolipin, centromere protein A, collagen II, histones H2A and H2B, heparan sulphate, heparin, mitochondrial 2, nuclear Mi-2, nucleoporin 62 and vimentin) autoAbs were present at significantly different levels in NPSLE. The combination of IgG autoAbs against heparan sulphate, histone H2B and vimentin could differentiate NPSLE from non-NPSLE (area under the curve 0.845, 99.97% CI: 0.756, 0.933; P < 0.0001). Compared with non-NPSLE, four IgG and seven IgM autoAbs were significantly associated with inflammatory NPSLE. In ischaemic NPSLE, three IgG and three IgM autoAbs were significantly different from non-NPSLE patients. Conclusion: In our cohort, the presence of high levels of anti-heparan sulphate and anti-histone H2B combined with low levels of anti-vimentin IgG autoAbs is highly suggestive of NPSLE. These results need to be validated in external cohorts.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Vasculite Associada ao Lúpus do Sistema Nervoso Central/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Autoanticorpos/imunologia
Biomarcadores/sangue
Estudos de Casos e Controles
Feminino
Heparitina Sulfato/imunologia
Histonas/imunologia
Seres Humanos
Imunoglobulina G/imunologia
Vasculite Associada ao Lúpus do Sistema Nervoso Central/imunologia
Masculino
Meia-Idade
Análise Serial de Proteínas
Vimentina/imunologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Biomarkers); 0 (Histones); 0 (Immunoglobulin G); 0 (Vimentin); 9050-30-0 (Heparitin Sulfate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex073


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[PMID]:29367524
[Au] Autor:Ichinose K
[Ad] Endereço:Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences.
[Ti] Título:[Unmet needs in systemic lupus erythematosus].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(6):396-407, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple lesions that cause inflammation and the production of autoantibodies. Lupus nephritis (LN) and neuropsychiatric SLE (NPSLE) are common organ-threatening manifestations of SLE and result in significant morbidity and mortality. In the last 30 years, steroids and immunosuppressive drugs have improved the prognosis of patients with SLE, and today the 5-year survival rate exceeds 90%. However, the treatment of SLE still largely depends on these medications and sometimes results in death due to complications. In recent years, biologic agents and low-molecular-weight compounds have emerged that are expected to be effective against refractory LN and NPSLE. For the diagnosis of SLE, the classification revised in 1997 proposed by the American College of Rheumatology and the classification standards of the Systemic Lupus International Collaborating Clinics 2012 classification criteria have been used, but they are not necessarily useful for early diagnosis. New biomarkers are needed for the early diagnosis of SLE. In this article, we summarize the unmet needs of diagnosis and treatment with SLE, especially those with LN and NPSLE, with data from our own experiences.
[Mh] Termos MeSH primário: Lúpus Eritematoso Sistêmico
[Mh] Termos MeSH secundário: Animais
Biomarcadores
Diagnóstico Precoce
Feminino
Seres Humanos
Lúpus Eritematoso Sistêmico/diagnóstico
Lúpus Eritematoso Sistêmico/tratamento farmacológico
Lúpus Eritematoso Sistêmico/imunologia
Nefrite Lúpica
Vasculite Associada ao Lúpus do Sistema Nervoso Central
Masculino
Camundongos
Terapia de Alvo Molecular
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.396


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[PMID]:28457083
[Au] Autor:Brogna C; Manna R; Contaldo I; Romeo DM; Stefanini MC; Chiaretti A; Mercuri E; Mariotti P
[Ad] Endereço:Department of Pediatric Neurology, Catholic University, Gemelli Hospital, Rome, Italy.
[Ti] Título:Intravenous immunoglobulin for Pediatric Neuropsychiatric Lupus Triggered by Epstein-Barr Virus Cerebral Infection.
[So] Source:Isr Med Assoc J;18(12):763-766, 2016 Dec.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Mh] Termos MeSH primário: Viroses do Sistema Nervoso Central/complicações
Infecções por Vírus Epstein-Barr/complicações
Imunoglobulinas Intravenosas/administração & dosagem
Vasculite Associada ao Lúpus do Sistema Nervoso Central/tratamento farmacológico
[Mh] Termos MeSH secundário: Viroses do Sistema Nervoso Central/virologia
Criança
Seres Humanos
Fatores Imunológicos/administração & dosagem
Vasculite Associada ao Lúpus do Sistema Nervoso Central/virologia
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous); 0 (Immunologic Factors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29036223
[Au] Autor:Asano T; Ito H; Kariya Y; Hoshi K; Yoshihara A; Ugawa Y; Sekine H; Hirohata S; Yamaguchi Y; Sato S; Kobayashi H; Migita K; Ohira H; Hashimoto Y; Watanabe H
[Ad] Endereço:Department of Rheumatology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
[Ti] Título:Evaluation of blood-brain barrier function by quotient alpha2 macroglobulin and its relationship with interleukin-6 and complement component 3 levels in neuropsychiatric systemic lupus erythematosus.
[So] Source:PLoS One;12(10):e0186414, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although quotient of alpha2 macroglobulin (Qα2MG) was previously reported to be useful for the evaluation of blood-brain barrier (BBB) function, it is not commonly used. We therefore evaluated BBB function among the various subsets of neuropsychiatric systemic lupus erythematosus (NPSLE) using quotient Q α2MG. Furthermore, we determined the correlation between Q α2MG and cerebrospinal (CSF) interleukin (IL)-6 level and quotient complement component 3 (Q C3). To determine intrathecal production of C3, the C3 index (Q C3/Q α2MG) was also calculated. Fifty-six patients with SLE were included in this study. Of these, 48 were diagnosed with NPSLE, consisting of 30 diffuse NPSLE patients (acute confusional state (ACS): n = 14, non-ACS: n = 16) and 18 patients with focal NPSLE. CSF IL-6 concentration, and paired serum and CSF levels of α2MG and C3, were measured by enzyme-linked immuno solvent assay (ELISA). The Q α2MG, Q C3, and C3 index were then calculated. Q α2MG, Q C3, and IL-6 concentrations in the CSF were significantly elevated in NPSLE compared with non-NPSLE. Among the subsets of NPSLE, significant increases in Q α2MG, CSF IL-6, and Q C3 were observed in ACS compared with non-ACS or focal NPSLE. There was a positive correlation between CSF IL-6 level and Q α2MG, as well as between Q C3 and Q α2MG, in diffuse NPSLE. There were no significant differences in C3 index between NPSLE and non-NPSLE, as well as among the subgroups of NPSLE. Our study suggests that BBB disruption is present in ACS, and elevated levels of IL-6 and C3 in CSF in diffuse NPSLE, especially in ACS, might result from their entry to the CSF from the systemic circulation through the damaged BBB, as well as increased intrathecal production. Furthermore, Q α2MG might be useful for the evaluation of BBB integrity.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/metabolismo
Complemento C3/líquido cefalorraquidiano
Interleucina-6/líquido cefalorraquidiano
Vasculite Associada ao Lúpus do Sistema Nervoso Central/líquido cefalorraquidiano
alfa-Macroglobulinas/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Glucose/líquido cefalorraquidiano
Seres Humanos
Vasculite Associada ao Lúpus do Sistema Nervoso Central/sangue
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (C3 protein, human); 0 (Complement C3); 0 (Interleukin-6); 0 (alpha-Macroglobulins); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186414


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[PMID]:28807492
[Au] Autor:Lei HW; Wang JY; Dang QJ; Yang F; Liu X; Zhang JH; Li Y
[Ad] Endereço:Department of Rheumatology and Immunology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China.
[Ti] Título:Neuropsychiatric involvement in lupus is associated with the Nogo-a/NgR1 pathway.
[So] Source:J Neuroimmunol;311:22-28, 2017 Oct 15.
[Is] ISSN:1872-8421
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Neuroinflammation- and neurodegeneration-induced nerve injury may represent important components of neuropsychiatric lupus (NPSLE). Myelin-associated neurite outgrowth inhibitor (Nogo)-a and its receptor, NgR1, limit recovery of the adult central nervous system after injury. We detected a soluble Nogo-a product in the cerebral spinal fluid of patients with NPSLE. In a mouse model of lupus, aging was associated with an increase in Nogo-a positive neurons, diminished myelin sheaths, enhanced pro-inflammatory cytokines, and impaired cognition and memory. Treatment with the Nogo-66 antagonist promoted myelin repair, improved cognition and memory, and downregulated pro-inflammatory factors. Our data imply the Nogo-a/NgR1 pathway is involved in NPSLE.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Vasculite Associada ao Lúpus do Sistema Nervoso Central/metabolismo
Vasculite Associada ao Lúpus do Sistema Nervoso Central/patologia
Proteínas Nogo/metabolismo
Receptor Nogo 1/metabolismo
Transdução de Sinais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Animais
Encéfalo/patologia
Citocinas/genética
Citocinas/metabolismo
Modelos Animais de Doenças
Feminino
Seres Humanos
Vasculite Associada ao Lúpus do Sistema Nervoso Central/tratamento farmacológico
Vasculite Associada ao Lúpus do Sistema Nervoso Central/genética
Masculino
Aprendizagem em Labirinto/fisiologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Meia-Idade
Proteínas da Mielina/uso terapêutico
Neurônios/metabolismo
Proteínas Nogo/genética
Receptor Nogo 1/genética
Fragmentos de Peptídeos/uso terapêutico
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Myelin Proteins); 0 (NEP1-40 protein, human); 0 (Nogo Proteins); 0 (Nogo Receptor 1); 0 (Peptide Fragments)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


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[PMID]:28614301
[Au] Autor:Bialas AR; Presumey J; Das A; van der Poel CE; Lapchak PH; Mesin L; Victora G; Tsokos GC; Mawrin C; Herbst R; Carroll MC
[Ad] Endereço:Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
[Ti] Título:Microglia-dependent synapse loss in type I interferon-mediated lupus.
[So] Source:Nature;546(7659):539-543, 2017 06 22.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of patients with SLE experience neuropsychiatric symptoms that range from anxiety, depression and cognitive impairment to seizures and, in rare cases, psychosis-collectively this is referred to as central nervous system (CNS) lupus. In some cases, certain autoantibodies, such as anti-NMDAR or anti-phospholipid antibodies, promote CNS lupus. However, in most patients, the mechanisms that underlie these symptoms are unknown. CNS lupus typically presents at lupus diagnosis or within the first year, suggesting that early factors contributing to peripheral autoimmunity may promote CNS lupus symptoms. Here we report behavioural phenotypes and synapse loss in lupus-prone mice that are prevented by blocking type I interferon (IFN) signalling. Furthermore, we show that type I IFN stimulates microglia to become reactive and engulf neuronal and synaptic material in lupus-prone mice. These findings and our observation of increased type I IFN signalling in post-mortem hippocampal brain sections from patients with SLE may instruct the evaluation of ongoing clinical trials of anifrolumab, a type I IFN-receptor antagonist. Moreover, identification of IFN-driven microglia-dependent synapse loss, along with microglia transcriptome data, connects CNS lupus with other CNS diseases and provides an explanation for the neurological symptoms observed in some patients with SLE.
[Mh] Termos MeSH primário: Interferon Tipo I/imunologia
Vasculite Associada ao Lúpus do Sistema Nervoso Central/imunologia
Vasculite Associada ao Lúpus do Sistema Nervoso Central/patologia
Microglia/imunologia
Microglia/patologia
Sinapses/patologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais/uso terapêutico
Comportamento Animal
Modelos Animais de Doenças
Feminino
Hipocampo/metabolismo
Hipocampo/patologia
Seres Humanos
Interferon Tipo I/antagonistas & inibidores
Vasculite Associada ao Lúpus do Sistema Nervoso Central/psicologia
Masculino
Camundongos
Microglia/metabolismo
Fenótipo
Transdução de Sinais
Sinapses/imunologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Interferon Type I); 0 (anifrolumab)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1038/nature22821


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[PMID]:28428121
[Au] Autor:Stock AD; Gelb S; Pasternak O; Ben-Zvi A; Putterman C
[Ad] Endereço:Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave. F701, Bronx, NY 10461, United States.
[Ti] Título:The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface.
[So] Source:Autoimmun Rev;16(6):612-619, 2017 Jun.
[Is] ISSN:1873-0183
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Experts have previously postulated a linkage between lupus associated vascular pathology and abnormal brain barriers in the immunopathogenesis of neuropsychiatric lupus. Nevertheless, there are some discrepancies between the experimental evidence, or its interpretation, and the working hypotheses prevalent in this field; specifically, that a primary contributor to neuropsychiatric disease in lupus is permeabilization of the blood brain barrier. In this commonly held view, any contribution of the other known brain barriers, including the blood-cerebrospinal fluid and meningeal barriers, is mostly excluded from the discussion. In this review we will shed light on some of the blood brain barrier hypotheses and try to trace their roots. In addition, we will suggest new research directions to allow for confirmation of alternative interpretations of the experimental evidence linking the pathology of intra-cerebral vasculature to the pathogenesis of neuropsychiatric lupus.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/imunologia
Vasculite Associada ao Lúpus do Sistema Nervoso Central/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


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[PMID]:28394236
[Au] Autor:Ribeiro FM; Signorelli F
[Ad] Endereço:1 Rheumatology Department, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:The role of infections in neuropsychiatric lupus.
[So] Source:Lupus;26(5):490-496, 2017 Apr.
[Is] ISSN:1477-0962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Opportunistic infections can cause manifestations that resemble neuropsychiatric systemic lupus erythematosus and they can also trigger lupus flares. Therefore, central nervous system infections as differential diagnosis in neuropsychiatric systemic lupus erythematosus may be difficult, leading to delayed diagnosis and specific treatment. Central nervous system infection in systemic lupus erythematosus is not common but, if left misdiagnosed and not treated promptly, can be fatal. Complementary diagnosis tests are generally non-specific and disappointing. Caution with immunosuppressive drug treatment should be emphasized while an opportunistic infection cannot be ruled out. In this review, we discuss the various types of central nervous system infections reported in systemic lupus erythematosus patients, highlighting the importance of their early recognition in order to improve morbidity and mortality. Prevention with vaccination is a recommended approach.
[Mh] Termos MeSH primário: Doenças do Sistema Nervoso Central/microbiologia
Lúpus Eritematoso Sistêmico/tratamento farmacológico
Vasculite Associada ao Lúpus do Sistema Nervoso Central/diagnóstico
Infecções Oportunistas/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Diagnóstico Precoce
Feminino
Seres Humanos
Imunossupressores/efeitos adversos
Imunossupressores/uso terapêutico
Lúpus Eritematoso Sistêmico/complicações
Masculino
Infecções Oportunistas/complicações
Exacerbação dos Sintomas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1177/0961203317691375


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[PMID]:28394235
[Au] Autor:Clark KE; Clark CN; Rahman A
[Ad] Endereço:1 Centre for Rheumatology, Division of Medicine, University College London, London, UK.
[Ti] Título:A critical analysis of the tools to evaluate neuropsychiatric lupus.
[So] Source:Lupus;26(5):504-509, 2017 Apr.
[Is] ISSN:1477-0962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neuropsychiatric symptoms occur commonly in patients with systemic lupus erythematosus, but they are not always due to active disease. It is crucial to identify cases that are due to active systemic lupus erythematosus so that appropriate treatment can be instituted. There is no single serological or imaging test that distinguishes active neuropsychiatric systemic lupus erythematosus from neuropsychiatric manifestations caused by other factors such as infection. Most patients with neuropsychiatric systemic lupus erythematosus have generalised features of disease activity. Raised anti-dsDNA and low C3 complement levels are often seen, but are not an invariable guide. The presence of antiphospholipid antibodies is more suggestive of thrombotic than inflammatory causation. A number of other autoantibody tests have been proposed as biomarkers for neuropsychiatric systemic lupus erythematosus, but results in clinical studies have been inconsistent and none has so far entered routine clinical practice. Cerebrospinal fluid features and magnetic resonance imaging appearances are non-specific in neuropsychiatric systemic lupus erythematosus, but are useful in excluding other causes of neuropsychiatric symptoms. Newer magnetic resonance imaging sequences show promise for distinguishing new neuropsychiatric systemic lupus erythematosus activity from previous damage and recent research suggests these may correlate with changes in cognitive function in patients with systemic lupus erythematosus. However, formal cognitive testing is seldom carried out in the acute setting.
[Mh] Termos MeSH primário: Disfunção Cognitiva/diagnóstico
Lúpus Eritematoso Sistêmico/complicações
Vasculite Associada ao Lúpus do Sistema Nervoso Central/diagnóstico por imagem
Neuroimagem/métodos
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Seres Humanos
Lúpus Eritematoso Sistêmico/líquido cefalorraquidiano
Lúpus Eritematoso Sistêmico/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1177/0961203317690242


  10 / 705 MEDLINE  
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[PMID]:28394237
[Au] Autor:Pikman R; Kivity S; Levy Y; Arango MT; Chapman J; Yonath H; Shoenfeld Y; Gofrit SG
[Ad] Endereço:1 Israel Defense Forces Medical Corps, Ramat Gan, Israel.
[Ti] Título:Neuropsychiatric SLE: from animal model to human.
[So] Source:Lupus;26(5):470-477, 2017 Apr.
[Is] ISSN:1477-0962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Animal models are a key element in disease research and treatment. In the field of neuropsychiatric lupus research, inbred, transgenic and disease-induced mice provide an opportunity to study the pathogenic routes of this multifactorial illness. In addition to achieving a better understanding of the immune mechanisms underlying the disease onset, supplementary metabolic and endocrine influences have been discovered and investigated. The ever-expanding knowledge about the pathologic events that occur at disease inception enables us to explore new drugs and therapeutic approaches further and to test them using the same animal models. Discovery of the molecular targets that constitute the pathogenic basis of the disease along with scientific advancements allow us to target these molecules with monoclonal antibodies and other specific approaches directly. This novel therapy, termed "targeted biological medication" is a promising endeavor towards producing drugs that are more effective and less toxic. Further work to discover additional molecular targets in lupus' pathogenic mechanism and to produce drugs that neutralize their activity is needed to provide patients with safe and efficient methods of controlling and treating the disease.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Vasculite Associada ao Lúpus do Sistema Nervoso Central/patologia
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Autoanticorpos/metabolismo
Citocinas/metabolismo
Predisposição Genética para Doença
Seres Humanos
Vasculite Associada ao Lúpus do Sistema Nervoso Central/genética
Vasculite Associada ao Lúpus do Sistema Nervoso Central/metabolismo
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Cytokines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1177/0961203317694261



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