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  1 / 11 MEDLINE  
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[PMID]:28726620
[Au] Autor:Murhekar MV
[Ti] Título:Acute Encephalitis Syndrome and Scrub Typhus in India.
[So] Source:Emerg Infect Dis;23(8):1434, 2017 08.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril
Tifo por Ácaros
[Mh] Termos MeSH secundário: Seres Humanos
Índia
Orientia tsutsugamushi
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.3201/eid2308.162028


  2 / 11 MEDLINE  
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[PMID]:28555777
[Au] Autor:Farias-Moeller R; Bartolini L; Staso K; Schreiber JM; Carpenter JL
[Ad] Endereço:Center for Neuroscience, Children's National Health System, George Washington University, Washington, District of Columbia, U.S.A.
[Ti] Título:Early ictal and interictal patterns in FIRES: The sparks before the blaze.
[So] Source:Epilepsia;58(8):1340-1348, 2017 Aug.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Febrile infection-related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy described as explosive onset of super refractory status epilepticus (SRSE) in previously healthy children. We describe electroencephalography (EEG) abnormalities in the hyperacute phase of FIRES, with the aim of contributing to the diagnostic characterization of a syndrome otherwise lacking specific biomarkers. METHODS: This is a retrospective single-center, case series of seven children with FIRES. Cases were identified from a Neurocritical Care database. Patient characteristics and clinical course were obtained from electronic medical records. Electroencephalography recordings were reviewed in two segments: the initial 12 h of recording and the 12 h prior to initiation of a medically induced burst suppression (BS). RESULTS: Fourteen 12-h segments of video-electroencephalography (EEG) recordings were analyzed for commonalities. A beta-delta complex resembling extreme delta brush (EDB) occurred in at least one 12-h segment for all patients. In six patients, seizures were brief and relatively infrequent during the first recording, with a gradual evolution to status epilepticus by the second. We observed a characteristic electrographic seizure pattern in six of seven patients with prolonged focal fast activity at onset. Shifting seizures were seen in four of seven patients. SIGNIFICANCE: The diagnosis of FIRES is typically assigned late in a patient's clinical course, which has broad implications for clinical care and research. We retrospectively analyzed acute EEG features in seven patients with FIRES and discovered three common features: gradual increase in seizure burden, presence of a recurrent EDB, and a typical seizure pattern. Recognition of this pattern may facilitate early diagnosis and treatment.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/complicações
Ritmo Delta/fisiologia
Epilepsia/complicações
[Mh] Termos MeSH secundário: Encefalopatia Aguda Febril/fisiopatologia
Adolescente
Criança
Pré-Escolar
Eletroencefalografia
Epilepsia/fisiopatologia
Feminino
Seres Humanos
Masculino
Estudos Retrospectivos
Fatores de Tempo
Gravação em Vídeo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13801


  3 / 11 MEDLINE  
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[PMID]:28427112
[Au] Autor:Setlakwe EL; Johnson AL
[Ad] Endereço:Department of Clinical Studies-New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, PA, 19348.
[Ti] Título:Acute encephalopathy in a 2-year-old pot-bellied pig following accidental intoxication with clonazepam.
[So] Source:J Vet Emerg Crit Care (San Antonio);27(3):369-372, 2017 May.
[Is] ISSN:1476-4431
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To describe a case of successful management of clonazepam toxicity causing encephalopathy in a pot-bellied pig. CASE SUMMARY: A 2-year-old female pot-bellied pig weighing 13.5 kg was presented for evaluation of clinical signs of acute encephalopathy. Based on the animal's history and clinical signs, a tentative diagnosis of benzodiazepine (BZP) intoxication was made. The results of a urinary drug screening test designed to detect illicit substances in human urine indicated benzodiazepine exposure. Gas chromatography and mass spectrometry analysis later confirmed clonazepam (urinary concentration 496 ng/mL) as the intoxicating substance. The pig responded favorably to treatment which included administration of flumazenil, decontamination with enteral activated charcoal, and intravenous isotonic crystalloid administration. The pig had a rapid improvement in mentation 10 minutes following IV flumazenil administration and was considered mentally appropriate following 24 hours of hospitalization. The pig was discharged from the hospital after 48 hours of care, and was reported to be doing well 6 months later. NEW INFORMATION PROVIDED: Intoxication with prescription benzodiazepines can occur in companion animals and result in clinical signs of acute encephalopathy. Urinary drug screening tests designed for human use may provide rapid results to indicate drug intoxication and guide therapeutic intervention in veterinary species. Administration of flumazenil resulted in a rapid improvement in mentation following clonazepam intoxication in a pot-bellied pig.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/veterinária
Clonazepam/toxicidade
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/veterinária
Doenças dos Suínos/diagnóstico
[Mh] Termos MeSH secundário: Encefalopatia Aguda Febril/diagnóstico
Encefalopatia Aguda Febril/fisiopatologia
Animais
Antídotos/uso terapêutico
Diagnóstico Diferencial
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/fisiopatologia
Emergências/veterinária
Feminino
Flumazenil/uso terapêutico
Infusões Intravenosas/veterinária
Suínos
Doenças dos Suínos/fisiopatologia
Doenças dos Suínos/urina
Porco Miniatura
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Antidotes); 40P7XK9392 (Flumazenil); 5PE9FDE8GB (Clonazepam)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1111/vec.12602


  4 / 11 MEDLINE  
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[PMID]:28264024
[Au] Autor:Bhattarai A; Pant ND; Nepal K; Adhikari S; Sharma M; Parajuli P
[Ad] Endereço:Department of Microbiology, St. Xavier's College, Maitighar, Kathmandu, Nepal.
[Ti] Título:Anti Japanese encephalitis virus IgM positivity among patients with acute encephalitic syndrome admitted to different hospitals from all over Nepal.
[So] Source:PLoS One;12(3):e0173434, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Japanese encephalitis virus (JEV) infection is one of the major public health problems in Nepal because of its increasing disease morbidity and mortality. The main purpose of this study was to determine the anti-JEV IgM positivity among acute encephalitis syndromic cases from all over Nepal. The present study was conducted at National Public Health Laboratory, Kathmandu, Nepal from April 2015 to October 2015. A total of 671 (418 CSF and 253 serum) samples were collected from 625 patients with acute encephalitic syndrome, admitted to different hospitals from all over Nepal. IgM antibody capture enzyme linked immunosorbent assay (ELISA) was used for the detection of anti-JEV IgM positive cases. The rate of anti-JEV IgM positivity was found to be 21.12%. The majority of positive cases (50%) were from the age group below 15 years, with the highest numbers of cases occurring in September (55.30%). Among all the anti-JEV IgM positive cases, higher numbers of cases were males. Geographically, the highest numbers of anti-JEV IgM positive cases were recorded from Terai region. Similarly, largest numbers of anti-JEV IgM positive cases were reported from Kailai district followed by those from Kanchanpur. However, anti-JEV IgM positive cases were also reported from hill districts. Continuation of active surveillance and vector control measures, proper management of diagnostic facilities and expanded program of immunization in JE endemic areas should be strongly emphasized to reduce the endemicity of the disease.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/epidemiologia
Encefalopatia Aguda Febril/imunologia
Vírus da Encefalite Japonesa (Espécie)/imunologia
Hospitalização
Imunoglobulina M/imunologia
[Mh] Termos MeSH secundário: Encefalopatia Aguda Febril/sangue
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Feminino
Geografia Médica
Seres Humanos
Imunoglobulina M/sangue
Lactente
Recém-Nascido
Masculino
Meia-Idade
Nepal/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RETRACTED PUBLICATION
[Nm] Nome de substância:
0 (Immunoglobulin M)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173434


  5 / 11 MEDLINE  
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[PMID]:28027569
[Au] Autor:Neubauer BA
[Ad] Endereço:Department of Pediatric Neurology, University Hospital Giessen, Giessen, Germany.
[Ti] Título:Treatment of Super-Refractory Status Epilepticus in FIRES.
[So] Source:Neuropediatrics;48(1):3-4, 2017 Feb.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/complicações
Estado Epiléptico/etiologia
Estado Epiléptico/terapia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1597615


  6 / 11 MEDLINE  
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[PMID]:27940505
[Au] Autor:Kawai Y; DeMonbrun AG; Chambers RS; Nolan DA; Dolcourt BA; Malas NM; Quasney MW
[Ad] Endereço:Divisions of Pediatric Critical Care Medicine and kawai.yu@mayo.edu.
[Ti] Título:A Previously Healthy Adolescent With Acute Encephalopathy and Decorticate Posturing.
[So] Source:Pediatrics;139(1), 2017 Jan.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 14-year-old previously healthy female was transferred from a local emergency department after being found unresponsive at home. Parental questioning revealed she had fever and pharyngitis 2 weeks before presentation. Past mental health history was negative, including concern for past or present suicidal ideation/attempts, suspected substance use, or toxic ingestion. In the emergency department, she was orotracheally intubated due to a Glasgow Coma Scale of 3. She was hemodynamically stable and euglycemic. Electrocardiogram showed sinus tachycardia. She underwent a noncontrast head computed tomography that was normal and subsequently underwent a lumbar puncture. She had a seizure and was given a loading dose of diazepam and fosphenytoin that led to cessation of extremity movements. She was subsequently transferred to the PICU for additional evaluation. Initial examination without sedation or analgesia demonstrated dilated and minimally responsive pupils, intermittent decorticate posturing, and bilateral lower extremity rigidity and clonus, consistent with a Glasgow Coma Scale of 5. Serum studies were unremarkable with the exception of mild leukocytosis. Chest radiograph only showed atelectasis. She was empirically started on antibiotics to cover for meningitis pending final cerebral spinal fluid test results. The pediatric neurology team was consulted for EEG monitoring, and the patient was eventually sent for computed tomography angiogram and magnetic resonance angiogram/venogram. We will review diagnostic evaluation and management of an adolescent patient with acute encephalopathy with decorticate posturing of unclear etiology.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/induzido quimicamente
Encefalopatia Aguda Febril/etiologia
Encefalopatia Aguda Febril/terapia
Amitriptilina/análogos & derivados
Bupropiona/toxicidade
Estado de Descerebração/induzido quimicamente
Estado de Descerebração/etiologia
Síndrome da Serotonina/diagnóstico
Tentativa de Suicídio
Cloridrato de Venlafaxina/toxicidade
[Mh] Termos MeSH secundário: Encefalopatia Aguda Febril/diagnóstico por imagem
Adolescente
Amitriptilina/toxicidade
Encéfalo/diagnóstico por imagem
Estado de Descerebração/diagnóstico por imagem
Diagnóstico Diferencial
Serviço Hospitalar de Emergência
Feminino
Escala de Coma de Glasgow
Seres Humanos
Unidades de Terapia Intensiva Pediátrica
Comunicação Interdisciplinar
Colaboração Intersetorial
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Automedicação
Tentativa de Suicídio/prevenção & controle
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
01ZG3TPX31 (Bupropion); 1806D8D52K (Amitriptyline); 69O5WQQ5TI (cyclobenzaprine); 7D7RX5A8MO (Venlafaxine Hydrochloride)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  7 / 11 MEDLINE  
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[PMID]:27919115
[Au] Autor:van Baalen A; Vezzani A; Häusler M; Kluger G
[Ad] Endereço:Department of Neuropediatrics, Christian-Albrechts-Universität zu Kiel, University Medical Center Schleswig-Holstein, Kiel, Germany.
[Ti] Título:Febrile Infection-Related Epilepsy Syndrome: Clinical Review and Hypotheses of Epileptogenesis.
[So] Source:Neuropediatrics;48(1):5-18, 2017 Feb.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Febrile infection-related epilepsy syndrome (FIRES, AERRPS, or DESC) is one of the most severe, mostly irreversible, and presumably immune-mediated epileptic encephalopathies affecting healthy children. Refractory status epilepticus or a cluster of seizures start a few days after the onset of an acute febrile illness; however, encephalitis cannot be proved. Sequelae of FIRES are drug-resistant epilepsy and neuropsychological impairments occurring without latency. Clinical knowledge is limited because FIRES is sporadic and extremely rare. Therefore, based on literature and our data, this review includes clinical features, terminology, epidemiology, diagnostic criteria and procedures, differential diagnoses, acute and chronic therapeutic options, and outcome data. Particular attention is paid to the epileptogenesis. We hypothesize that FIRES is an immune but not an autoimmune disease and discuss GABAergic therapy at high doses, avoidance of burst-suppression coma, and early introduction of enteral or even parenteral ketogenic diet as the most promising treatment. The lack of evidence requires both a network and a multinational web-based clinical registry to define the clinical spectrum for improving diagnosis and treatment and at the very least, to clarify the cause of FIRES. We conclude that the term "fulminant inflammatory response epilepsy syndrome" may be more appropriate.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/complicações
Estado Epiléptico/etiologia
Estado Epiléptico/terapia
[Mh] Termos MeSH secundário: Encefalopatia Aguda Febril/epidemiologia
Diagnóstico Diferencial
Seres Humanos
Estado Epiléptico/diagnóstico
Estado Epiléptico/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1597271


  8 / 11 MEDLINE  
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[PMID]:27459916
[Au] Autor:Kuya K; Fujii S; Miyoshi F; Ohno K; Shinohara Y; Maegaki Y; Ogawa T
[Ad] Endereço:Division of Radiology, Department of Pathophysiological Therapeutic Science, Faculty of Medicine, Tottori University, Japan. Electronic address: keita98_1_7@hotmail.co.jp.
[Ti] Título:A case of acute encephalopathy with biphasic seizures and late reduced diffusion: Utility of arterial spin labeling sequence.
[So] Source:Brain Dev;39(1):84-88, 2017 Jan.
[Is] ISSN:1872-7131
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A 1-year-old boy was admitted because of febrile status epilepticus (FSE). A secondary cluster of seizures was seen on day 5 after onset, and the patient eventually displayed developmental delay. Conventional magnetic resonance imaging (MRI) showed no abnormal findings on day 1 after onset, but showed reduced diffusion in the subcortical regions of bilateral frontal lobes on day 5 after onset. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was diagnosed. Arterial spin labeling (ASL) revealed reduced cerebral blood flow (CBF) in bilateral frontal lobes on day 1 after onset and showed increased CBF in the corresponding region in the subacute phase. Outcomes after prolonged febrile seizures are usually good, but mental deficit and/or epilepsy often remain in AESD. Discriminating between these syndromes is difficult, because no useful biomarkers have been identified. Reduced CBF in bilateral frontal lobes was observed on ASL on day 1 of FSE in the present case, and this finding may be predictive of developing AESD.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/diagnóstico por imagem
Circulação Cerebrovascular
Lobo Frontal/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Convulsões Febris/diagnóstico por imagem
[Mh] Termos MeSH secundário: Encefalopatia Aguda Febril/fisiopatologia
Circulação Cerebrovascular/fisiologia
Deficiências do Desenvolvimento/diagnóstico por imagem
Deficiências do Desenvolvimento/etiologia
Diagnóstico Diferencial
Progressão da Doença
Seguimentos
Lobo Frontal/fisiopatologia
Seres Humanos
Lactente
Masculino
Convulsões Febris/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE


  9 / 11 MEDLINE  
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[PMID]:27434885
[Au] Autor:Mirás Veiga A; Moreno DC; Menéndez AI; Siscart IM; Fernández MD; Sánchez EG; González MG; Sáez FG
[Ad] Endereço:Department of Pediatric Intensive Care Unit, Hospital Universitario de Burgos, Burgos, Spain.
[Ti] Título:Effectiveness of Electroconvulsive Therapy for Refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome.
[So] Source:Neuropediatrics;48(1):45-48, 2017 Feb.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Febrile infection-related epilepsy syndrome (FIRES) is a rare condition which evolves into refractory status epilepticus (SE), with poor outcome in most cases. Conventional antiepileptic drugs fail to control SE in FIRES patients. We report the case of a previously healthy 4-year-old boy who was diagnosed with FIRES. One week after pharyngitis and high fever he started seizures, followed by refractory SE. Benzodiazepines, phenytoin, high-dose barbiturates that induce burst suppression, high doses of corticosteroids, plasmapheresis, immunoglobulins, propofol, lidocaine, ketamine, inhaled desflurane, ketogenic diet, lacosamide, and therapeutic hypothermia were tried at different times in a period of 8 weeks, but all of them were ineffective. Electroconvulsive therapy (ECT) has been used in refractory SE in children. We report a case in which ECT was successfully used for treatment of refractory SE in a pediatric patient with FIRES syndrome.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/complicações
Eletroconvulsoterapia/métodos
Estado Epiléptico/etiologia
Estado Epiléptico/terapia
[Mh] Termos MeSH secundário: Anticonvulsivantes/uso terapêutico
Pré-Escolar
Eletroencefalografia
Seres Humanos
Masculino
Estado Epiléptico/líquido cefalorraquidiano
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1584939


  10 / 11 MEDLINE  
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[PMID]:27325387
[Au] Autor:Prakash S; Makwana P; Rathore C; Dave A
[Ad] Endereço:Department of Neurology, Smt B. K. Shah Medical Institute and Research Center, Sumandeep Vidyapeeth, Piparia, Waghodia, Vadodara, Gujarat, 391760, India. drprakashs@yahoo.co.in.
[Ti] Título:Serotonin syndrome presenting as febrile encephalopathy with CSF pleocytosis: a report of three cases.
[So] Source:Neurol Sci;37(9):1561-4, 2016 Sep.
[Is] ISSN:1590-3478
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Serotonin syndrome (SS) is an iatrogenic, drug-induced clinical syndrome caused by serotoninergic hyperstimulation. SS may have protean manifestations and can mimic a variety of medical conditions. Herein, we describe three cases of febrile encephalopathy who were on serotonergic agents. All three cases fulfilled Hunter's criteria for SS and responded to the removal of the offending agents and the administration of cyproheptadine. All three patients had abnormal cerebrospinal fluid (CSF) examinations (pleocytosis in three patients and increased protein in two patients) which returned to normal with therapy. We suggest that SS presenting as febrile encephalopathy may have transient CSF abnormalities. Severe SS is a medical emergency. Therefore, a trial of cyproheptadine can be given in patients fulfilling the SS criteria even in the presence of CSF abnormalities. In parallel, the patients should be investigated for other causes of febrile encephalopathy and CSF pleocytosis.
[Mh] Termos MeSH primário: Encefalopatia Aguda Febril/tratamento farmacológico
Leucocitose/líquido cefalorraquidiano
Leucocitose/complicações
Serotoninérgicos/efeitos adversos
Síndrome da Serotonina/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Serotonin Agents)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE
[do] DOI:10.1007/s10072-016-2638-2



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