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[PMID]:27166520
[Au] Autor:Yamaguchi Y; Nakazato S; Izumi K; Ieko M; Nomura T; Shimizu H
[Ad] Endereço:Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
[Ti] Título:Rapid remission of severe pain from livedoid vasculopathy by apixaban.
[So] Source:J Eur Acad Dermatol Venereol;31(1):e45-e46, 2017 Jan.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doença Cerebrovascular dos Gânglios da Base/tratamento farmacológico
Inibidores do Fator Xa/uso terapêutico
Dor/tratamento farmacológico
Dor/etiologia
Pirazóis/uso terapêutico
Piridonas/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Livedo Reticular/tratamento farmacológico
Meia-Idade
Dermatopatias Vasculares/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Factor Xa Inhibitors); 0 (Pyrazoles); 0 (Pyridones); 3Z9Y7UWC1J (apixaban)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.13691


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[PMID]:26940316
[Au] Autor:Kleine JF; Beller E; Zimmer C; Kaesmacher J
[Ad] Endereço:Department of Neuroradiology, Klinikum Rechts der Isar, TU München, München, Germany.
[Ti] Título:Lenticulostriate infarctions after successful mechanical thrombectomy in middle cerebral artery occlusion.
[So] Source:J Neurointerv Surg;9(3):234-239, 2017 Mar.
[Is] ISSN:1759-8486
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In stroke due to middle cerebral artery (MCA) occlusion, collaterals may sustain tissue in the peripheral MCA territory, extending the time window for recanalizing therapies. However, MCA occlusions often block some or all of the 'lenticulostriate' (LS) arteries originating from the M1 segment, eliminating blood flow to dependent territories in the striatum, which have no collateral supply. This study examines whether mechanical thrombectomy (MTE) can avert imminent striatal infarction in patients with acute MCA occlusion. METHODS: 279 patients with isolated MCA occlusion subjected to MTE were included. Actual LS occlusions and infarctions were assigned to predefined 'LS occlusion' and 'LS infarct' patterns derived from known LS vascular anatomy. The predictive performance of LS occlusion patterns regarding ensuing infarction in striatal subterritories was assessed by standard statistical measures. RESULTS: LS occlusion patterns predicted infarction in associated striatal subterritories with a positive predictive value (PPV) of 91% and a negative predictive value of 81%. In 15 of the 22 patients who did not develop the predicted striatal infarctions, reassessment of angiographies revealed LS vascular supply variants that explained these 'false positive' LS occlusion patterns, raising the PPV to 96%. Symptom onset to recanalization times were relatively short, but this alone could not account for the false positive LS occlusion patterns in the remaining seven of these patients. CONCLUSIONS: With currently achievable symptom onset to recanalization times, striatal infarctions are determined by MCA occlusion sites and individual vascular anatomy, and cannot normally be averted by MTE, but there are exceptions. Further study of such exceptional cases may yield important insights into the determinants of infarct growth in the hyperacute phase of infarct evolution.
[Mh] Termos MeSH primário: Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Infarto da Artéria Cerebral Média/diagnóstico por imagem
Infarto da Artéria Cerebral Média/terapia
Trombólise Mecânica/tendências
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Doença Cerebrovascular dos Gânglios da Base/etiologia
Estudos de Coortes
Feminino
Seres Humanos
Infarto da Artéria Cerebral Média/complicações
Masculino
Trombólise Mecânica/efeitos adversos
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.1136/neurintsurg-2015-012243


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[PMID]:27452127
[Au] Autor:Park MG; Oh EH; Kim BK; Park KP
[Ad] Endereço:Department of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Mulgeum, Yangsan 626-770, Republic of Korea.
[Ti] Título:Intravenous tissue plasminogen activator in acute branch atheromatous disease: Does it prevent early neurological deterioration?
[So] Source:J Clin Neurosci;33:194-197, 2016 Nov.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Early neurological deterioration (END) and poor outcome frequently occur in lenticulostriate artery (LSA) infarction due to branch atheromatous disease (BAD). We evaluate whether the tissue plasminogen activator (tPA) can prevent END and improve the outcome by comparing with anti-platelet treatment in LSA infarction due to BAD. We enrolled the patients with LSA infarction due to BAD who arrived at the hospital within 24h from onset, and divided those into two groups by whether tPA was given or not. END and good outcome (modified Rankin score: 0-1) at 3months were examined between two groups. Consecutive 35 patients of LSA infarction due to BAD enrolled in this study. Nine patients were given tPA (tPA group) and 26 patients antiplatelets only (non-tPA group). Patients in tPA group showed no symptomatic hemorrhage. END occurred in 68.6% (24/35) of all patients, 66.7% (6/9) of tPA group and 69.2% (18/26) of non-tPA group (p=0.886). The proportion of good outcome at 3months were 25.7% in all patients, 22.2% (2/9) in tPA group and 26.9% (7/26) in non-tPA (p=0.781). tPA did not adequately prevent END, and did not show better outcome in LSA infarction due to BAD compared with antiplatelet therapy only. More effective treatment strategies are needed for prevention of END and favourable outcome in BAD.
[Mh] Termos MeSH primário: Fibrinolíticos/uso terapêutico
Doenças do Sistema Nervoso/prevenção & controle
Placa Aterosclerótica/tratamento farmacológico
Ativador de Plasminogênio Tecidual/uso terapêutico
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Doença Cerebrovascular dos Gânglios da Base/complicações
Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Imagem de Difusão por Ressonância Magnética
Progressão da Doença
Feminino
Fibrinolíticos/administração & dosagem
Seres Humanos
Infusões Intravenosas
Hemorragias Intracranianas/etiologia
Hemorragias Intracranianas/prevenção & controle
Masculino
Meia-Idade
Placa Aterosclerótica/diagnóstico por imagem
Placa Aterosclerótica/etiologia
Inibidores da Agregação de Plaquetas/uso terapêutico
Estudos Retrospectivos
Acidente Vascular Cerebral/etiologia
Acidente Vascular Cerebral/terapia
Ativador de Plasminogênio Tecidual/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fibrinolytic Agents); 0 (Platelet Aggregation Inhibitors); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


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[PMID]:27425175
[Au] Autor:Niimi M; Abo M; Miyano S; Sasaki N; Hara T; Yamada N
[Ad] Endereço:Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: pomardon2010@gmail.com.
[Ti] Título:Comparison of Functional Outcome between Lacunar Infarction and Branch Atheromatous Disease in Lenticulostriate Artery Territory.
[So] Source:J Stroke Cerebrovasc Dis;25(9):2271-5, 2016 Sep.
[Is] ISSN:1532-8511
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Branch atheromatous disease (BAD) is differentiated from lacunar infarction (LI). BAD is often associated with neurological deterioration in the acute stage, but outcome of BAD patients in the chronic stage is unclear. We aimed to explore the outcome of BAD in the lenticulostriate artery (LSA) territory in comparison with those of LI from the viewpoint of activities of daily living (ADLs). METHODS: We retrospectively investigated patients who were admitted within 3 days after stroke onset. The patients underwent daily rehabilitation during hospitalization. BAD in LSA territory was defined by the presence of lesion representing 3 or more consecutive horizontal slices in magnetic resonance imaging. Patients having atrial fibrillation or more than 50% stenosis of the large artery in magnetic resonance angiography were excluded. We retrieved data on clinical characteristics and evaluation from medical records. RESULTS: Subjects were 41 BAD and 35 LI patients. There was little difference in baseline characteristics. The National Institutes of Health Stroke Scale score was significantly higher in BAD patients (P < .05). The Barthel Index (BI) score and the Brunnstrom recovery stage were lower in BAD patients at admission (P < .05 and P < .05). Hospital stay was longer in BAD patients (P < .01), but the BI score at discharge was not different. To ambulate, 8 BAD and 1 LI patients depended on orthoses (P < .05), and 21 BAD and 7 LI patients used canes (P < .01). Multivariable analysis demonstrated that BAD lesion was correlated with AFO use independent of age and sex. CONCLUSIONS: BAD patients can obtain ADLs similar to LI patients. However, many BAD patients require canes and/or orthoses.
[Mh] Termos MeSH primário: Doença Cerebrovascular dos Gânglios da Base/complicações
Placa Aterosclerótica/etiologia
Acidente Vascular Cerebral Lacunar/etiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Imagem de Difusão por Ressonância Magnética
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Placa Aterosclerótica/diagnóstico por imagem
Estudos Retrospectivos
Índice de Gravidade de Doença
Acidente Vascular Cerebral Lacunar/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE


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[PMID]:27344149
[Au] Autor:Alarcon A; Martinez-Biarge M; Cabañas F; Quero J; García-Alix A
[Ad] Endereço:Neonatal Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
[Ti] Título:A Prognostic Neonatal Neuroimaging Scale for Symptomatic Congenital Cytomegalovirus Infection.
[So] Source:Neonatology;110(4):277-285, 2016.
[Is] ISSN:1661-7819
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Congenital cytomegalovirus (cCMV) can cause brain inflammation/destruction and teratogenic effects. The only validated neuroimaging prognostic categorization for symptomatic cCMV available is based on destructive lesions seen on computed tomography (CT). OBJECTIVE: The aim of this study was to establish the predictive ability of a comprehensive neonatal neuroimaging scale in symptomatic cCMV. METHODS: Twenty-six infants were studied by neonatal cranial ultrasound scans (US; n = 25), CT (n = 11) and magnetic resonance imaging (MRI; n = 9). A previously validated neuroimaging scale comprising calcifications, ventriculomegaly and atrophy was compared to a newly proposed system adding cerebral dysgenesis and white matter disease. The findings were graded from 0 to 3. Neurodevelopmental assessment included motor and cognitive functions, epilepsy, vision, hearing and behavioral disorders. RESULTS: Both scales showed a significant association with outcome (p < 0.005). Our scale was more accurate in predicting death or moderate-severe disability (area under the curve for scores ≥2, 0.88 ± 0.06 vs. 0.80 ± 0.08). All 5 infants with normal neuroimaging survived with intact neurological function. While our scale was highly associated with outcome in patients studied by MRI, it was unable to predict unfavorable outcomes in 2 patients with mildly abnormal US and/or CT. CONCLUSIONS: A comprehensive scale based on US and MRI predicts neurodevelopment in symptomatic cCMV. Significant destructive lesions are associated with a poor prognosis. While a strictly normal cranial US predicts a favorable outcome, in case of subtle US abnormalities, MRI is crucial for prognostication.
[Mh] Termos MeSH primário: Infecções por Citomegalovirus/congênito
Infecções por Citomegalovirus/diagnóstico por imagem
Deficiências do Desenvolvimento/diagnóstico
Substância Branca/patologia
[Mh] Termos MeSH secundário: Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Paralisia Cerebral/diagnóstico por imagem
Cognição
Ecoencefalografia
Feminino
Seres Humanos
Recém-Nascido
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Malformações do Desenvolvimento Cortical/diagnóstico por imagem
Neuroimagem
Prognóstico
Estudos Prospectivos
Índice de Gravidade de Doença
Espanha
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160627
[St] Status:MEDLINE


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[PMID]:27148776
[Au] Autor:Barrea C; Vigouroux T; Karam J; Milet A; Vaessen S; Misson JP
[Ad] Endereço:Division of Child Neurology, Department of Pediatrics, Centre Hospitalier Régional, Liège, Belgium.
[Ti] Título:Horner Syndrome in Children: A Clinical Condition with Serious Underlying Disease.
[So] Source:Neuropediatrics;47(4):268-72, 2016 Aug.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Aim Horner syndrome corresponds to the clinical triad of miosis, ptosis, and facial anhidrosis. These symptoms are related to injury of the oculosympathetic chain. In children, Horner syndrome is classified as congenital or acquired. While the diagnosis is made through clinical examination, there is some debate regarding the use of imaging modalities and the extent of anatomical coverage required. Methods Here, we describe two cases of children with acute Horner syndrome. We then review the literature about the different etiology and discuss the interest of some investigations. Results Case 1: An 8-month-old girl without personal or familial history, has presented a right acquired Horner syndrome without additional signs. Frontal chest radiography and ultrasonography of the neck and the abdomen was first achieved and returned normal. The cerebral and cervical magnetic resonance imaging (MRI) with angiographic sequences performed in a second time was also normal. Finally, an enhanced thoracic computed tomography (CT)-scan demonstrated a mass at the right pulmonary apex. Case 2: A 9-year-old boy without personal or familial history has presented an acute headache with loss of consciousness during a basketball competition. Upon waking up, the child has right hemiplegia, aphasia, and left Horner syndrome. The cerebral CT scan realized in the first line was normal. The MRI with angiographic sequences demonstrated M1 left carotid dissection with homolateral white matter infarction. Conclusion Imaging studies seem critical in delineating the nature and extent of any underlying pathology along the oculosympathetic pathway in children presenting a Horner syndrome. In these patients, a history of trauma or surgery may reduce the need for extensive systemic evaluation. Without such anamnesis, a decision to proceed with further evaluation is made with consideration of the relative incidence of tumor, especially neuroblastoma, or other treatable lesions. In this condition, MRI is the more sensitive and recommended investigation.
[Mh] Termos MeSH primário: Dissecação da Artéria Carótida Interna/complicações
Síndrome de Horner/etiologia
Neoplasias Pulmonares/complicações
Neuroblastoma/complicações
[Mh] Termos MeSH secundário: Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Doença Cerebrovascular dos Gânglios da Base/etiologia
Infarto Encefálico/diagnóstico por imagem
Infarto Encefálico/etiologia
Dissecação da Artéria Carótida Interna/diagnóstico por imagem
Criança
Feminino
Seres Humanos
Lactente
Neoplasias Pulmonares/diagnóstico por imagem
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Masculino
Neuroblastoma/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1584085


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[PMID]:26937385
[Au] Autor:Ishaque M; Manning JH; Woolsey MD; Franklin CG; Tullis EW; Fox PT
[Ad] Endereço:Research Imaging Institute, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229, USA; Department of Radiological Sciences, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
[Ti] Título:Lenticulostriate arterial distribution pathology may underlie pediatric anoxic brain injury in drowning.
[So] Source:Neuroimage Clin;11:167-72, 2016.
[Is] ISSN:2213-1582
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Drowning is a leading cause of neurological morbidity and mortality in young children. Anoxic brain injury (ABI) can result from nonfatal drowning and typically entails substantial neurological impairment. The neuropathology of drowning-induced pediatric ABI is not well established. Specifically, quantitative characterization of the spatial extent and tissue distribution of anoxic damage in pediatric nonfatal drowning has not previously been reported but could clarify the underlying pathophysiological processes and inform clinical management. To this end, we used voxel-based morphometric (VBM) analyses to quantify the extent and spatial distribution of consistent, between-subject alterations in gray and white matter volume. Whole-brain, high-resolution T1-weighted MRI datasets were acquired in 11 children with chronic ABI and 11 age- and gender-matched neurotypical controls (4-12 years). Group-wise VBM analyses demonstrated predominantly central subcortical pathology in the ABI group in both gray matter (bilateral basal ganglia nuclei) and white matter (bilateral external and posterior internal capsules) (P < 0.001); minimal damage was found outside of these deep subcortical regions. These highly spatially convergent gray and white matter findings reflect the vascular distribution of perforating lenticulostriate arteries, an end-arterial watershed zone, and suggest that vascular distribution may be a more important determinant of tissue loss than oxygen metabolic rate in pediatric ABI. Further, these results inform future directions for diagnostic and therapeutic modalities.
[Mh] Termos MeSH primário: Doença Cerebrovascular dos Gânglios da Base/patologia
Afogamento/fisiopatologia
Substância Cinzenta/patologia
Hipóxia Encefálica/etiologia
Hipóxia Encefálica/patologia
[Mh] Termos MeSH secundário: Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Doença Cerebrovascular dos Gânglios da Base/etiologia
Estudos de Casos e Controles
Pré-Escolar
Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Hipóxia Encefálica/diagnóstico por imagem
Imagem Tridimensional
Lactente
Imagem por Ressonância Magnética
Masculino
Substância Branca/diagnóstico por imagem
Substância Branca/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170301
[Lr] Data última revisão:
170301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160304
[St] Status:MEDLINE
[do] DOI:10.1016/j.nicl.2016.01.019


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[PMID]:26797370
[Au] Autor:Chen YC; Li YH; Lu J; Li WB; Wang JB
[Ad] Endereço:1 Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yi Shan Rd, Shanghai, China, 200233.
[Ti] Título:Correlation Between the Reduction in Lenticulostriate Arteries Caused by Hypertension and Changes in Brain Metabolism Detected With MRI.
[So] Source:AJR Am J Roentgenol;206(2):395-400, 2016 Feb.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hypertension can alter the vascular structure, mechanics, and function of small arteries and arterioles. It remains unknown whether microvascular changes are associated with brain metabolism. The purpose of this study was to analyze the correlation between the reduction in small arteries and changes in brain metabolism in patients with hypertension. SUBJECTS AND METHODS: The study population comprised 50 patients with hypertension and 50 volunteers without hypertension. The two groups underwent 3-T 3D time-of-flight MR angiography, and the numbers of lenticulostriate arteries (LSAs) were determined for both groups. Single-voxel proton MR spectroscopic data on the basal ganglia regions were also acquired. The ratios of N-acetylaspartate to creatine (NAA/Cr), myo-inositol to creatine (Mi/Cr), and choline to creatine (Cho/Cr) were measured. Statistical analysis was performed to evaluate the differences between the two groups with respect to metabolite ratios. RESULTS: The average total number of LSA stems on both sides in patients with hypertension was 5.12 ± 0.98 compared with 6.10 ± 0.95 in volunteers without hypertension (p < 0.0001). The NAA/Cr ratio decreased according to a reduction in the number of LSAs in the hypertension group, which was significantly reduced when the number of LSAs was 3 or fewer. CONCLUSION: Hypertension can lead to a statistically significant reduction in NAA/Cr ratio in the basal ganglia regions when the number of LSAs decreases to a certain extent. Reduced numbers of LSAs correlated with brain metabolism changes caused by hypertension, which can provide important insights for understanding the pathophysiologic mechanism of hypertension and may be valuable in evaluating this disease.
[Mh] Termos MeSH primário: Doença Cerebrovascular dos Gânglios da Base/diagnóstico
Corpo Estriado/irrigação sanguínea
Hipertensão/complicações
[Mh] Termos MeSH secundário: Adulto
Doença Cerebrovascular dos Gânglios da Base/etiologia
Doença Cerebrovascular dos Gânglios da Base/metabolismo
Encéfalo/metabolismo
Encéfalo/patologia
Núcleo Caudado/irrigação sanguínea
Núcleo Caudado/metabolismo
Núcleo Caudado/patologia
Corpo Estriado/metabolismo
Corpo Estriado/patologia
Feminino
Seres Humanos
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160122
[Lr] Data última revisão:
160122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.15.14514


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[PMID]:26742641
[Au] Autor:Li Y; Chen Z; Su X; Zhang X; Wang P; Zhu Y; Xu Q; Xu J; Tong S
[Ad] Endereço:School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
[Ti] Título:Functional lateralization in cingulate cortex predicts motor recovery after basal ganglia stroke.
[So] Source:Neurosci Lett;613:6-12, 2016 Feb 02.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The basal ganglia (BG) is involved in higher order motor control such as movement planning and execution of complex motor synergies. Neuroimaging study on stroke patients specifically with BG lesions would help to clarify the consequence of BG damage on motor control. In this paper, we performed a longitudinal study in the stroke patients with lesions in BG regions across three motor recovery stages, i.e., less than 2week (Session 1), 1-3m (Session 2) and more than 3m (Session 3). The patients showed an activation shift from bilateral hemispheres during early sessions (<3m) to the ipsilesional cortex in late session (>3m), suggesting a compensation effect from the contralesional hemisphere during motor recovery. We found that the lateralization of cerebellum(CB) for affected hand task correlated with patients' concurrent Fugl-Meyer index (FMI) in Session 2. Moreover, the cingulate cortex lateralization index in Session 2 was shown to significantly correlate with subsequent FMI change between Session 3 and Session 2, which serves as a prognostic marker for motor recovery. Our findings consolidated the close interactions between BG and CB during the motor recovery after stroke. The dominance of activation in contralateral cingulate cortex was associated with a better motor recovery, suggesting the important role of ipsilesional attention modulation in the early stage after BG stroke.
[Mh] Termos MeSH primário: Doença Cerebrovascular dos Gânglios da Base/fisiopatologia
Lateralidade Funcional
Giro do Cíngulo/fisiopatologia
Destreza Motora
Acidente Vascular Cerebral/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Neuroimagem
Reabilitação do Acidente Vascular Cerebral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160109
[St] Status:MEDLINE


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[PMID]:26704207
[Au] Autor:Saito A; Kon H; Nakamura T; Sasaki T
[Ad] Endereço:Department of Neurosurgery, Aomori Prefectural Central Hospital, Aomori, Japan. Electronic address: satsushi2002@yahoo.co.jp.
[Ti] Título:A Dissecting Aneurysm of the Distal Medial Lenticulostriate Artery: Case Report.
[So] Source:World Neurosurg;89:725.e1-4, 2016 May.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Medial lenticulostriate artery (MLSA) aneurysms are rare; to our knowledge, only 2 cases without an association with moyamoya disease have been documented. We treated a ruptured dissecting aneurysm of the distal MLSA surgically using a tube retractor. CASE DESCRIPTION: A 66-year-old woman suffered a sudden-onset disturbance in consciousness. Computed tomography showed diffuse subarachnoid hemorrhage and a dense intraventricular hematoma associated with acute hydrocephalus. She underwent emergent ventricular drainage. Angiography revealed a 3-mm distal MLSA aneurysm. On repeat angiographs, the aneurysm had not disappeared. Because the stenotic, narrow structure of the proximal portion of the MLSA disallowed the endovascular approach, we performed direct surgery via the transventricular approach using a tube retractor. The aneurysm on the intraventricular surface of the anterior horn of the lateral ventricle adjacent to the caudate nucleus was exposed. We resected the aneurysm under transcranial motor-evoked potential monitoring because neck clipping would have endangered the patency of the MLSA. Her postoperative course was uneventful. The pathologic diagnosis was ruptured dissecting aneurysm. CONCLUSIONS: There is no definitive strategy to treat distal MLSA aneurysms. Our experience illustrates that natural healing of the vessel wall cannot be expected in all cases. Therefore, less-invasive direct surgical as well as endovascular treatment should not be ruled out in patients with ruptured distal MLSA aneurysms.
[Mh] Termos MeSH primário: Aneurisma Roto/diagnóstico por imagem
Aneurisma Roto/cirurgia
Doença Cerebrovascular dos Gânglios da Base/diagnóstico por imagem
Doença Cerebrovascular dos Gânglios da Base/cirurgia
[Mh] Termos MeSH secundário: Idoso
Aneurisma Roto/complicações
Doença Cerebrovascular dos Gânglios da Base/complicações
Angiografia Cerebral
Feminino
Seres Humanos
Tomógrafos Computadorizados
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE



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