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[PMID]:29227072
[Au] Autor:Tanoue Y; Shiose A
[Ti] Título:The Present Situation and Clinical Topics of Ventricular Assist Device and Heart Transplantation in Japan.
[So] Source:Fukuoka Igaku Zasshi;107(12):213-22, 2016 12.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Surgical treatment for heart failure includes coronary artery bypass grafting to ischemic heart disease, valvular disease surgery such as mitral valvuloplasty, left ventricular restoration, ventricular assist device (VAD), and heart transplantation. In addition, HeartSheet which is regenerative medicine using autologous skeletal myoblast sheets has been started from the spring of 2016. Formal insurance reimbursement of implantable LVAD was obtained in April 2011, and the life prognosis of patients with severe heart failure improved markedly. However, the indication for implantable LVAD is limited to bridge use for heart transplantation. Implantable LVAD cannot be implanted in patients over 65 years old under health insurance because the adaptive age of heart transplantation in Japan is under 65 years old. It is a problem that the indication of implantable LVAD is identical to that of heart transplantation. Clinical trial of destination therapy is in progress for the purpose of optimizing the implantable LVAD indication. I strongly pray that VAD treatment including destination therapy (DT) and transplant medical treatment based on good intentions will be accepted socially as general treatment.
[Mh] Termos MeSH primário: Cardiopatias/cirurgia
Transplante de Coração
Coração Auxiliar
[Mh] Termos MeSH secundário: Morte Encefálica
Seres Humanos
Japão
Doadores de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; ENGLISH ABSTRACT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28457388
[Au] Autor:Dibo FHA; Gravena ÂAF; de Freitas RA; Dell'Agnolo CM; de Almeida Benguella E; Pelloso SM; de Barros Carvalho MD
[Ad] Endereço:Postgraduate Program in Health Sciences, State University of Maringá, Paraná, Brazil. Electronic address: opniq@bol.com.br.
[Ti] Título:Brain Death: Knowledge of Future Brazilian Physicians.
[So] Source:Transplant Proc;49(4):750-755, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Thousands of people die on the waiting list for transplants. The shortage of organs and tissues for transplantation is considered a serious global problem. Brain death (BD) is the main source of organs for transplantations. OBJECTIVE: Given that BD is assessed by medical staff and that this diagnosis is ethically relevant, the goal of this work was to analyze the knowledge of 5th- and 6th-year medical students of Southern Brazil regarding the process of determining BD. METHOD: This observational, cross-sectional study was conducted between September 2013 and March 2014. RESULTS: A total of 635 students participated in the study, with 337 (53.1%) from public and 298 (46.9%) from private schools. Approximately 333 (52.4%) attended the 6th year of the medical program. The mean age of the students was 25.4 ± 3.56 years, with a prevalence of females of 54.6% (347) and a prevalence of Catholic religion of 61.7% (392); 84.2% of the students reported not feeling confident performing the BD protocol. A low percentage (15.7%) correctly answered 75% or more of the questions about BD, a criterion used to determine sufficient knowledge of BD. Approximately 45% (282) of respondents were not able to identify the patients who were candidates for the BD protocol. Analyzing the medical students' knowledge at the end of the program can provide information about the quality of undergraduate education on the topic of determining BD. CONCLUSION: It was concluded that 5th- and 6th-year medical students of Paraná State have little knowledge about the BD protocol.
[Mh] Termos MeSH primário: Morte Encefálica/diagnóstico
Conhecimentos, Atitudes e Prática em Saúde
Estudantes de Medicina
[Mh] Termos MeSH secundário: Adulto
Brasil
Estudos Transversais
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28457385
[Au] Autor:Baroncelli F; Alberione MC; Cacciotti V; Artusio D; Vergano M; Livigni S
[Ad] Endereço:Scuola di Specializzazione in Anestesia, Rianimazione e Terapia Intensiva, Università degli Studi di Torino, Torino, Italy.
[Ti] Título:Blood Lactate Concentrations Before and After Withdrawal of Life-Sustaining Treatments in Controlled Donation After Circulatory Death: A Case Report From Italy.
[So] Source:Transplant Proc;49(4):740-742, 2017 May.
[Is] ISSN:1873-2623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 20-minute hands-off period with isoelectric electrocardiography (ECG) monitoring is currently required for the declaration of cardiac death in Italy, thus prolonging the warm ischemia time (WIT) during donation after circulatory death (DCD). Normothermic regional perfusion (NRP) can be a valid tool to optimize organ perfusion as a bridge to donation. A 62-year-old woman with catastrophic brain injury due to massive intracranial hemorrage, not fulfilling brain death criteria, underwent controlled DCD after withdrawal of life-sustaining therapies (WLST). NRP was established after a functional WIT of 43 minutes. Despite concerns regarding a prolonged WIT imposed by the national legislation on declaration of cardiac death, NRP was successful in restoring an adequate perfusion to liver and kidneys, as evidenced by a sustained reduction in blood lactate concentration. Liver and kidneys were successfully transplanted after ex vivo machine perfusion.
[Mh] Termos MeSH primário: Morte Encefálica/diagnóstico
Ácido Láctico/sangue
Preservação de Órgãos/métodos
Coleta de Tecidos e Órgãos/métodos
Isquemia Quente
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Itália
Meia-Idade
Perfusão
Doadores de Tecidos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28742700
[Au] Autor:Kalisvaart M; de Haan JE; Polak WG; Metselaar HJ; Wijnhoven BPL; IJzermans JNM; de Jonge J
[Ad] Endereço:*Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands †Department of Adult Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands ‡Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
[Ti] Título:Comparison of Postoperative Outcomes Between Donation After Circulatory Death and Donation After Brain Death Liver Transplantation Using the Comprehensive Complication Index.
[So] Source:Ann Surg;266(5):772-778, 2017 11.
[Is] ISSN:1528-1140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To test the total burden of complications in the early postoperative period after liver transplantation (LT) between donation after circulatory death (DCD) and donation after brain death (DBD) grafts with the novel Comprehensive Complication Index (CCI). BACKGROUND: LT is complex surgery and the increasing use of high-risk grafts is pressuring current postoperative outcomes. DCD grafts in particular are associated with ischemic-type biliary lesions (ITBL) with subsequent impaired graft survival rates. METHODS: Retrospective single-center study of all LT since the start of DCD program (2001-2015). CCI (at hospital discharge and after 6 months) was the result of all complications weighted by their Clavien-Dindo grade. A multiple logistic regression model was used to identify factors associated with a complex postoperative course (CCI at 6 months >60). RESULTS: In total, 441 cases were included: 115 DCD and 326 DBD grafts. Median in-hospital CCI was comparable for both groups (DCD 38.2; DBD 36.7; P = 0.429). Six-month postoperative median CCI was significantly higher for DCD grafts (53.4 vs 47.2; P = 0.041). Moreover, more DCD recipients underwent retransplantation for ITBL in this period (4% vs 1%; P = 0.031). Logistic regression identified recipient BMI (P = 0.046), recipient warm ischemia time (odds ratio, OR, 1.032; 95% CI, 1.008-1.056; P = 0.008), and DCD graft (OR 3.913; 95% CI 1.200-12.767; P = 0.024) as risk factors for a CCI >60. CONCLUSIONS: This analysis shows a comparable complication rate during the index hospital stay for DCD and DBD LT, but the CCI increases significantly for DCD recipients in 6 months after transplantation. Reduction of biliary complications, especially ITBL, is needed to improve the outcomes for DCD grafts.
[Mh] Termos MeSH primário: Morte Encefálica
Seleção do Doador/métodos
Transplante de Fígado
Complicações Pós-Operatórias/etiologia
Doadores de Tecidos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seguimentos
Sobrevivência de Enxerto
Seres Humanos
Estimativa de Kaplan-Meier
Transplante de Fígado/mortalidade
Modelos Logísticos
Masculino
Meia-Idade
Avaliação de Resultados (Cuidados de Saúde)
Complicações Pós-Operatórias/epidemiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1097/SLA.0000000000002419


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[PMID]:28749083
[Au] Autor:Menegat L; Simas R; Caliman JM; Zanoni FL; Jacysyn JF; da Silva LFF; Borelli P; Moreira LFP; Sannomiya P
[Ad] Endereço:Heart Institute (InCor), LIM 11, University of São Paulo Medical School, São Paulo, SP, Brazil.
[Ti] Título:Evidence of bone marrow downregulation in brain-dead rats.
[So] Source:Int J Exp Pathol;98(3):158-165, 2017 06.
[Is] ISSN:1365-2613
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Experimental findings support the evidence of a persistent leucopenia triggered by brain death (BD). This study aimed to investigate leucocyte behaviour in bone marrow and blood after BD in rats. BD was induced using intracranial balloon catheter inflation. Sham-operated (SH) rats were trepanned only. Thereafter bone marrow cells were harvested every six hours from the femoral cavity and used for total and differential counts. They were analysed further by flow cytometry to characterize lymphocyte subsets, granulocyte adhesion molecules expression and apoptosis/necrosis [annexin V/propidium iodide (PI) protocol]. BD rats exhibited a reduction in bone marrow cells due to a reduction in lymphocytes (40%) and segmented cells (45%). Bone marrow lymphocyte subsets were similar in BD and SH rats (CD3, P = 0.1; CD4, P = 0.4; CD3/CD4, P = 0.4; CD5, P = 0.4, CD3/CD5, P = 0.2; CD8, P = 0.8). Expression of L-selectin and beta -integrins on granulocytes did not differ (CD11a, P = 0.9; CD11b/c, P = 0.7; CD62L, P = 0.1). There were no differences in the percentage of apoptosis and necrosis (Annexin V, P = 0.73; PI, P = 0.21; Annexin V/PI, P = 0.29). In conclusion, data presented suggest that the downregulation of the bone marrow is triggered by brain death itself, and it is not related to changes in lymphocyte subsets, granulocyte adhesion molecules expression or apoptosis and necrosis.
[Mh] Termos MeSH primário: Células da Medula Óssea/patologia
Morte Encefálica/patologia
[Mh] Termos MeSH secundário: Animais
Apoptose
Células da Medula Óssea/imunologia
Células da Medula Óssea/metabolismo
Morte Encefálica/imunologia
Morte Encefálica/metabolismo
Moléculas de Adesão Celular/metabolismo
Modelos Animais de Doenças
Regulação para Baixo
Granulócitos/metabolismo
Hemodinâmica/fisiologia
Contagem de Leucócitos
Leucopenia/etiologia
Subpopulações de Linfócitos/imunologia
Masculino
Necrose
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cell Adhesion Molecules)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1111/iep.12234


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[PMID]:28985863
[Au] Autor:Resnick S; Seamon MJ; Holena D; Pascual J; Reilly PM; Martin ND
[Ad] Endereço:Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[Ti] Título:Early declaration of death by neurologic criteria results in greater organ donor potential.
[So] Source:J Surg Res;218:29-34, 2017 Oct.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aggressive management of patients prior to and after determination of death by neurologic criteria (DNC) is necessary to optimize organ recovery, transplantation, and increase the number of organs transplanted per donor (OTPD). The effects of time management are understudied but potentially pivotal component. The objective of this study was to analyze specific time points (time to DNC, time to procurement) and the time intervals between them to better characterize the optimal timeline of organ donation. METHODS: Using data over a 5-year time period (2011-2015) from the largest US OPO, all patients with catastrophic brain injury and donated transplantable organs were retrospectively reviewed. Active smokers were excluded. Maximum donor potential was seven organs (heart, lungs [2], kidneys [2], liver, and pancreas). Time from admission to declaration of DNC and donation was calculated. Mean time points stratified by specific organ procurement rates and overall OTPD were compared using unpaired t-test. RESULTS: Of 1719 Declaration of Death by Neurologic Criteria organ donors, 381 were secondary to head trauma. Smokers and organs recovered but not transplanted were excluded leaving 297 patients. Males comprised 78.8%, the mean age was 36.0 (±16.8) years, and 87.6% were treated at a trauma center. Higher donor potential (>4 OTPD) was associated with shorter average times from admission to brain death; 66.6 versus 82.2 hours, P = 0.04. Lung donors were also associated with shorter average times from admission to brain death; 61.6 versus 83.6 hours, P = 0.004. The time interval from DNC to donation varied minimally among groups and did not affect donation rates. CONCLUSIONS: A shorter time interval between admission and declaration of DNC was associated with increased OTPD, especially lungs. Further research to identify what role timing plays in the management of the potential organ donor and how that relates to donor management goals is needed.
[Mh] Termos MeSH primário: Morte Encefálica
Transplante de Órgãos/estatística & dados numéricos
Gerenciamento do Tempo
Doadores de Tecidos/estatística & dados numéricos
Obtenção de Tecidos e Órgãos/métodos
[Mh] Termos MeSH secundário: Adulto
Lesões Encefálicas
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Tempo
Obtenção de Tecidos e Órgãos/organização & administração
Obtenção de Tecidos e Órgãos/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:28947546
[Au] Autor:Rao V; Dhanani S; MacLean J; Payne C; Paltser E; Humar A; Zaltzman J
[Ad] Endereço:Division of Cardiovascular Surgery (Rao), Peter Munk Cardiac Centre, University of Toronto, Toronto, Ont.; Division of Critical Care (Dhanani), Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ont.; Trillium Gift of Life Network (MacLean, Payne, Paltser); Multiorgan Transplant U
[Ti] Título:Effect of organ donation after circulatory determination of death on number of organ transplants from donors with neurologic determination of death.
[So] Source:CMAJ;189(38):E1206-E1211, 2017 Sep 25.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To increase the available pool of organ donors, Ontario introduced donation after circulatory determination of death (DCD) in 2006. Other jurisdictions have reported a decrease in donations involving neurologic determination of death (NDD) after implementation of DCD, with a drop in organ yield and quality. In this study, we examined the effect of DCD on overall transplant activity in Ontario. METHODS: We examined deceased donor and organ transplant activity during 3 distinct 4-year eras: pre-DCD (2002/03 to 2005/06), early DCD (2006/07 to 2009/10) and recent DCD (2010/11 to 2013/14). We compared these donor groups by categorical characteristics. RESULTS: Donation increased by 57%, from 578 donors in the pre-DCD era to 905 donors in the recent DCD era, with a 21% proportion (190/905) of DCD donors in the recent DCD era. However, overall NDD donation also increased. The mean length of hospital stay before declaration for NDD was 2.7 days versus 6.0 days before withdrawal of life support and subsequent asystole in cases of DCD. The average organ yield was 3.73 with NDD donation versus 2.58 with DCD ( < 0.001). Apart from hearts, all organs from DCD donors were successfully transplanted. From the pre-DCD era to the recent DCD era, transplant activity in each era increased for all solid-organ recipients, including heart (from 158 to 216), kidney (from 821 to 1321), liver (from 477 to 657) and lung (from 160 to 305). INTERPRETATION: Implementation of DCD in Ontario led to increased transplant activity for all solid-organ recipients. There was no evidence that the use of DCD was pre-empting potential NDD donation. In contrast to groups receiving other organs, heart transplant candidates have not yet benefited from DCD.
[Mh] Termos MeSH primário: Doenças do Sistema Nervoso
Doadores de Tecidos/estatística & dados numéricos
Obtenção de Tecidos e Órgãos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Morte Encefálica
Morte
Sobrevivência de Enxerto
Seres Humanos
Ontário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.161043


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[PMID]:28932926
[Au] Autor:Tang Y; Han M; Chen M; Wang X; Ji F; Zhao Q; Zhang Z; Ju W; Wang D; Guo Z; He X
[Ad] Endereço:Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Er Road, Guangzhou, 510080, China.
[Ti] Título:Donor Indocyanine Green Clearance Test Predicts Graft Quality and Early Graft Prognosis After Liver Transplantation.
[So] Source:Dig Dis Sci;62(11):3212-3220, 2017 Nov.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transplantation centers have given much attention to donor availability. However, no reliable quantitative methods have been employed to accurately assess graft quality before transplantation. Here, we report that the indocyanine green (ICG) clearance test is a valuable index for liver grafts. METHODS: We performed the ICG clearance test on 90 brain-dead donors within 6 h before organ procurement between March 2015 and November 2016. We also analyzed the relationship between graft liver function and early graft survival after liver transplantation (LT). RESULTS: Our results suggest that the ICG retention rate at 15 min (ICGR15) of donors before procurement was independently associated with 3-month graft survival after LT. The best donor ICGR15 cutoff value was 11.0%/min, and we observed a significant increase in 3-month graft failure among patients with a donor ICGR15 above this value. On the other hand, a donor ICGR15 value of ≤ 11.0%/min could be used as an early assessment index of graft quality because it provides additional information to the transplant surgeon or organ procurement organization members who must maintain or improve organ function to adapt the LT. CONCLUSION: An ICG clearance test before liver procurement might be an effective quantitative method to predict graft availability and improve early graft prognosis after LT.
[Mh] Termos MeSH primário: Morte Encefálica/diagnóstico
Seleção do Doador
Corantes Fluorescentes/farmacocinética
Verde de Indocianina/farmacocinética
Testes de Função Hepática/métodos
Transplante de Fígado/métodos
Doadores de Tecidos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Área Sob a Curva
Morte Encefálica/fisiopatologia
Tomada de Decisão Clínica
Feminino
Corantes Fluorescentes/administração & dosagem
Sobrevivência de Enxerto
Seres Humanos
Verde de Indocianina/administração & dosagem
Transplante de Fígado/efeitos adversos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Curva ROC
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorescent Dyes); IX6J1063HV (Indocyanine Green)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-017-4765-x


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[PMID]:28926566
[Au] Autor:Zens TJ; Danobeitia JS; Chlebeck PJ; Zitur LJ; Odorico S; Brunner K; Coonen J; Capuano S; D'Alessandro AM; Matkowskyj K; Zhong W; Torrealba J; Fernandez L
[Ad] Endereço:University of Wisconsin Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
[Ti] Título:Guidelines for the management of a brain death donor in the rhesus macaque: A translational transplant model.
[So] Source:PLoS One;12(9):e0182552, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The development of a translatable brain death animal model has significant potential to advance not only transplant research, but also the understanding of the pathophysiologic changes that occur in brain death and severe traumatic brain injury. The aim of this paper is to describe a rhesus macaque model of brain death designed to simulate the average time and medical management described in the human literature. METHODS: Following approval by the Institutional Animal Care and Use Committee, a brain death model was developed. Non-human primates were monitored and maintained for 20 hours after brain death induction. Vasoactive agents and fluid boluses were administered to maintain hemodynamic stability. Endocrine derangements, particularly diabetes insipidus, were aggressively managed. RESULTS: A total of 9 rhesus macaque animals were included in the study. The expected hemodynamic instability of brain death in a rostral to caudal fashion was documented in terms of blood pressure and heart rate changes. During the maintenance phase of brain death, the animal's temperature and hemodynamics were maintained with goals of mean arterial pressure greater than 60mmHg and heart rate within 20 beats per minute of baseline. Resuscitation protocols are described so that future investigators may reproduce this model. CONCLUSION: We have developed a reproducible large animal primate model of brain death which simulates clinical scenarios and treatment. Our model offers the opportunity for researchers to have translational model to test the efficacy of therapeutic strategies prior to human clinical trials.
[Mh] Termos MeSH primário: Morte Encefálica/fisiopatologia
Modelos Animais de Doenças
[Mh] Termos MeSH secundário: Algoritmos
Animais
Pressão Sanguínea/efeitos dos fármacos
Morte Encefálica/veterinária
Hidratação
Guias como Assunto
Frequência Cardíaca/efeitos dos fármacos
Hemodinâmica/efeitos dos fármacos
Rim/patologia
Fígado/patologia
Macaca mulatta
Monitorização Fisiológica
Pâncreas/patologia
Doadores de Tecidos
Vasoconstritores/farmacologia
Ventiladores Mecânicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasoconstrictor Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182552


  10 / 7914 MEDLINE  
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[PMID]:28870982
[Au] Autor:Dahrenmöller C; Reding R
[Ad] Endereço:Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels 1200, Belgium carola.dahrenmoller@uclouvain.be.
[Ti] Título:Understanding the effect of corticosteroid pretreatment in brain-dead organ donors: new mechanistic insights for improvement of organ quality in liver transplantation.
[So] Source:Clin Sci (Lond);131(18):2377-2379, 2017 Sep 15.
[Is] ISSN:1470-8736
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Transplant surgeons are currently faced with the challenge to accept marginal liver transplants due to steatosis or old age. Improving organ quality by implementing a selective organ protective donor management could be the first step towards a graft of enhanced quality. However, the molecular mechanisms of such treatments are still poorly understood. Glucocorticoid medication in donor medicine has been carried out and discussed for a long time. In a recent study published in , Jiménez-Castro et al. [Clin. Sci. (2017) 131, 733-746] demonstrate how liver histology and transplant liver function can be improved by administration of glucocorticoids to brain-dead donor rats with steatotic livers. This work illustrates the need for further trials in order to selectively improve the quality of steatotic livers with a potential for liver transplantation.
[Mh] Termos MeSH primário: Morte Encefálica
Glucocorticoides/uso terapêutico
Transplante de Fígado/métodos
Fígado/efeitos dos fármacos
Doadores de Tecidos
[Mh] Termos MeSH secundário: Glucocorticoides/farmacologia
Seres Humanos
Fígado/patologia
Preservação de Órgãos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1042/CS20170178



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