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[PMID]:29386451
[Au] Autor:Kodama H
[Ad] Endereço:Department of Health and Dietetics, Faculty of Health and Medical Sciences, Teikyo Heisei University.
[Ti] Título:[Recent Trends of Trace Element Studies in Clinical Medicine in Japan].
[So] Source:Nihon Eiseigaku Zasshi;73(1):75-82, 2018.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Deficiencies of selenium and iodine are observed in patients who receive special formulas of milk and enteral formula with low selenium and iodine concentrations, respectively. In contrast, neonatal transient hypothyroidism due to excess intake of iodine in pregnant women has also reported in Japan. It is expected that collaborative studies by researchers and clinicians will contribute to clarify the detail mechanism, diagnosis and treatment of these abnormalities.
[Mh] Termos MeSH primário: Medicina Clínica/tendências
Oligoelementos
[Mh] Termos MeSH secundário: Cobre/deficiência
Feminino
Degeneração Hepatolenticular
Seres Humanos
Hipotireoidismo
Recém-Nascido
Japão
Masculino
Síndrome dos Cabelos Torcidos
Gravidez
Selênio/deficiência
Oligoelementos/deficiência
Zinco/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Trace Elements); 789U1901C5 (Copper); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.73.75


  2 / 953 MEDLINE  
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[PMID]:29419699
[Au] Autor:Peng CH; Hsu CH; Wang NL; Lee HC; Lin SP; Chan WT; Yeung CY; Jiang CB
[Ad] Endereço:Department of Pediatric Gastroenterology, Hepatology and Nutrition.
[Ti] Título:Spontaneous retroperitoneal hemorrhage in Menkes disease: A rare case report.
[So] Source:Medicine (Baltimore);97(6):e9869, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Menkes disease (MD), also known as Menkes kinky hair disease, is a fatal neurodegenerative disease caused by a defect in copper metabolism. The symptoms involve multiple organ systems, such as the brain, lung, gastrointestinal tract, urinary tract, connective tissue, and skin. There is currently no cure for this disease entity, and patients with the classic form of MD usually die from complications between 6 months and 3 years of age. Intracranial hemorrhage secondary to tortuous intracranial arteries is a well-known complication of MD, but spontaneous retroperitoneal hemorrhage, to the best of our knowledge, has never been reported in a patient with MD. Herein, we describe the first case of retroperitoneal hematoma as a complication of MD in a 4-year-old boy. PATIENT CONCERNS: A 4-year-old Taiwanese male patient with MD was referred to the hospital and presented with a palpable epigastric mass. DIAGNOSES: On the basis of the findings of ultrasonography and enhanced computed tomography, the diagnosis was retroperitoneal hematoma. INTERVENTIONS: Interventions included laparotomy with evacuation of the hematoma, manual compression, and suture of the bleeding vessels. OUTCOMES: There were no postoperative complications. LESSONS: This case emphasizes that bleeding in patients with MD is possible at any site in the body owing to the unstable structure of the connective tissues. Timely diagnosis with proper imaging studies can lead to prompt and appropriate management and save patients from this life-threatening condition.
[Mh] Termos MeSH primário: Hematoma
Hemostasia Cirúrgica/métodos
Síndrome dos Cabelos Torcidos/complicações
Espaço Retroperitoneal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Pré-Escolar
Hematoma/diagnóstico
Hematoma/etiologia
Seres Humanos
Laparotomia/métodos
Masculino
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Ultrassonografia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009869


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[PMID]:28397223
[Au] Autor:Shi X; Lin X; Ke Z; Chen S; Wu B; Mo G
[Ad] Endereço:Department of Pediatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China. shixiaorong1@163.com.
[Ti] Título:[Analysis of clinical features and genetic mutations in a Chinese family affected with Menkes disease].
[So] Source:Zhonghua Yi Xue Yi Chuan Xue Za Zhi;34(2):220-223, 2017 Apr 10.
[Is] ISSN:1003-9406
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To delineate the clinical features and potential mutation of the ATP7A gene in a family affected with Menkes disease. METHODS: Clinical data of a patient and his family members were analyzed. Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA) assays were performed to detect the mutation of the ATP7A gene. RESULTS: The patient was admitted at the age of 5 months due to severe epilepsy and marked delayed psychomotor development. Significantly light complexion, pudgy cheeks and sparse fuzzy wooly hair were noted. Cranial magnetic resonance imaging and angiography revealed cortical atrophy, leukoencephalopathy and circuitous of intracranial vessels. The plasma ceruloplasmin was decreased. MLPA has identified a deletion spanning exons 8 to 12 of the ATP7A gene. His mother was found to be a heterozygous carrier of the same mutation. CONCLUSION: The clinical features and a novel mutation of the ATP7A gene of the family have been delineated.
[Mh] Termos MeSH primário: Adenosina Trifosfatases/genética
Proteínas de Transporte de Cátions/genética
Síndrome dos Cabelos Torcidos/genética
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático/genética
China
ATPases Transportadoras de Cobre
Análise Mutacional de DNA
Éxons
Feminino
Heterozigoto
Seres Humanos
Lactente
Masculino
Mutação
Linhagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cation Transport Proteins); EC 3.6.1.- (Adenosine Triphosphatases); EC 3.6.3.54 (ATP7A protein, human); EC 3.6.3.54 (Copper-transporting ATPases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1003-9406.2017.02.015


  4 / 953 MEDLINE  
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[PMID]:28271632
[Au] Autor:Morrell A; Tallino S; Yu L; Burkhead JL
[Ad] Endereço:Department of Biological Sciences Anchorage, University of Alaska Anchorage, Anchorage, Alaska.
[Ti] Título:The role of insufficient copper in lipid synthesis and fatty-liver disease.
[So] Source:IUBMB Life;69(4):263-270, 2017 Apr.
[Is] ISSN:1521-6551
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The essential transition metal copper is important in lipid metabolism, redox balance, iron mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases where copper homeostasis is disrupted, including Menkes disease and Wilson disease, indicate the importance of copper balance to human health. The severe consequences of insufficient copper supply are illustrated by Menkes disease, caused by mutation in the X-linked ATP7A gene encoding a protein that transports copper from intestinal epithelia into the bloodstream and across the blood-brain barrier. Inadequate copper supply to the body due to poor diet quality or malabsorption can disrupt several molecular level pathways and processes. Though much of the copper distribution machinery has been described and consequences of disrupted copper handling have been characterized in human disease as well as animal models, physiological consequences of sub-optimal copper due to poor nutrition or malabsorption have not been extensively studied. Recent work indicates that insufficient copper may be important in a number of common diseases including obesity, ischemic heart disease, and metabolic syndrome. Specifically, marginal copper deficiency (CuD) has been reported as a potential etiologic factor in diseases characterized by disrupted lipid metabolism such as non-alcoholic fatty-liver disease (NAFLD). In this review, we discuss the available data suggesting that a significant portion of the North American population may consume insufficient copper, the potential mechanisms by which CuD may promote lipid biosynthesis, and the interaction between CuD and dietary fructose in the etiology of NAFLD. © 2016 IUBMB Life, 69(4):263-270, 2017.
[Mh] Termos MeSH primário: Cobre/metabolismo
Metabolismo dos Lipídeos/genética
Lipídeos/biossíntese
Hepatopatia Gordurosa não Alcoólica/metabolismo
[Mh] Termos MeSH secundário: Adenosina Trifosfatases/genética
Adenosina Trifosfatases/metabolismo
Barreira Hematoencefálica/metabolismo
Proteínas de Transporte de Cátions/genética
Proteínas de Transporte de Cátions/metabolismo
ATPases Transportadoras de Cobre
Dieta
Seres Humanos
Ferro/metabolismo
Lipídeos/genética
Fígado/metabolismo
Fígado/patologia
Síndrome dos Cabelos Torcidos/genética
Síndrome dos Cabelos Torcidos/metabolismo
Hepatopatia Gordurosa não Alcoólica/dietoterapia
Hepatopatia Gordurosa não Alcoólica/genética
Hepatopatia Gordurosa não Alcoólica/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cation Transport Proteins); 0 (Lipids); 789U1901C5 (Copper); E1UOL152H7 (Iron); EC 3.6.1.- (Adenosine Triphosphatases); EC 3.6.3.54 (ATP7A protein, human); EC 3.6.3.54 (Copper-transporting ATPases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1002/iub.1613


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[PMID]:28119449
[Au] Autor:Mercer SW; Wang J; Burke R
[Ad] Endereço:From the School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.
[Ti] Título: Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease.
[So] Source:J Biol Chem;292(10):4113-4122, 2017 Mar 10.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Copper is an essential biometal, and several inherited diseases are directly associated with a disruption to normal copper homeostasis. The best characterized are the copper deficiency and toxicity disorders Menkes and Wilson diseases caused by mutations in the p-type Cu-ATPase genes and , respectively. Missense mutations in the C-terminal portion of have also been shown to cause distal motor neuropathy, whereas polymorphisms in are associated with increased risk of Alzheimer's disease. We have generated a single, model for studying multiple pathogenic mutations in ATP7 proteins using , which has a single orthologue of ATP7A and ATP7B. Four pathogenic mutations and two mutations were introduced into a genomic rescue construct containing an in-frame C-terminal GFP tag. Analysis of the wild type transgene confirmed that ATP7 is expressed at the basolateral membrane of larval midgut copper cells and that the transgene can rescue a normally early lethal deletion allele to adulthood. Analysis of the transgenes containing pathogenic mutations showed that the function of ATP7 was affected, to varying degrees, by all six of the mutations investigated in this study. Of particular interest, the ATP7B Alzheimer's disease susceptibility allele was found, for the first time, to be a loss of function allele. This system allows us to assess the severity of individual / mutations in an invariant genetic background and has the potential to be used to screen for therapeutic compounds able to restore function to faulty copper transport proteins.
[Mh] Termos MeSH primário: Doença de Alzheimer/etiologia
Proteínas de Transporte de Cátions/genética
Drosophila melanogaster/genética
Degeneração Hepatolenticular/etiologia
Síndrome dos Cabelos Torcidos/etiologia
Neurônios Motores/patologia
Mutação/genética
[Mh] Termos MeSH secundário: Animais
ATPases Transportadoras de Cobre
Modelos Animais de Doenças
Drosophila melanogaster/crescimento & desenvolvimento
Drosophila melanogaster/metabolismo
Feminino
Masculino
Neurônios Motores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP7 protein, Drosophila); 0 (Cation Transport Proteins); EC 3.6.3.54 (Copper-transporting ATPases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.756163


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[PMID]:27002302
[Au] Autor:Caccavale S; Bove D; Bove RM; LA Montagna M
[Ad] Endereço:Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy.
[Ti] Título:Ataxia telangiectasia, Menkes kinky hair disease and neurocutaneous melanosis.
[So] Source:G Ital Dermatol Venereol;152(1):58-65, 2017 02.
[Is] ISSN:1827-1820
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:This article explores three neurocutaneous syndromes (NCSs), i.e. genetic disorders producing developmental abnormalities of the skin and an increased risk of neurological complications. In this review, different aspects of ataxia telangiectasia, Menkes kinky hair disease and neurocutaneous melanosis are examined: clinical features, genetic defect, mutation spectrum, pathogenesis, and neurobiological basis; indications for clinical practice are also provided to the readers. The aim of this review is to stress the importance of cooperation among dermatologists, neurologists and psychiatrists, in order to provide patients suffering from these diseases with timely diagnosis and targeted treatments.
[Mh] Termos MeSH primário: Ataxia Telangiectasia/fisiopatologia
Melanose/fisiopatologia
Síndrome dos Cabelos Torcidos/fisiopatologia
Síndromes Neurocutâneas/fisiopatologia
[Mh] Termos MeSH secundário: Ataxia Telangiectasia/diagnóstico
Ataxia Telangiectasia/terapia
Comportamento Cooperativo
Seres Humanos
Comunicação Interdisciplinar
Melanose/diagnóstico
Melanose/terapia
Síndrome dos Cabelos Torcidos/diagnóstico
Síndrome dos Cabelos Torcidos/terapia
Síndromes Neurocutâneas/diagnóstico
Síndromes Neurocutâneas/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.23736/S0392-0488.16.05083-5


  7 / 953 MEDLINE  
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[PMID]:25771438
[Au] Autor:Lin YJ; Ho CS; Hsu CH; Lin JL; Chuang CK; Tsai JD; Chiu NC; Lin HY; Lin SP
[Ad] Endereço:Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
[Ti] Título:A Truncating De Novo Point Mutation in a Young Infant with Severe Menkes Disease.
[So] Source:Pediatr Neonatol;58(1):89-92, 2017 Feb.
[Is] ISSN:2212-1692
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Menkes disease is a rare neurodegenerative disorder caused by mutations in ATP7A gene. Deficiency in copper-dependent enzymes results in the unique kinky hair appearance, neurodegeneration, developmental delay, seizures, failure to thrive and other connective tissue or organ abnormalities. Other than biochemical tests, DNA-based diagnosis is now playing an important role. More than two hundred mutations in ATP7A gene were identified. Early copper supplementation can help improve neurological symptoms, but not non-neurological problems. Further molecular studies are needed to identify additional mutation types and to understand the mechanism of pathogenesis. This may help in discovering the possible treatment measures to cure the disease. We present a case with the clinical features and biochemical findings, abnormal brain magnetic resonance imaging as well as the effects of treatment with copper-histidine. Direct sequencing of ATP7A gene revealed a de novo point mutation which resulted in an early stop codon with truncated protein.
[Mh] Termos MeSH primário: Adenosina Trifosfatases/genética
Proteínas de Transporte de Cátions/genética
Síndrome dos Cabelos Torcidos/diagnóstico
Síndrome dos Cabelos Torcidos/genética
Mutação Puntual/genética
[Mh] Termos MeSH secundário: ATPases Transportadoras de Cobre
Histidina/análogos & derivados
Histidina/uso terapêutico
Seres Humanos
Lactente
Masculino
Síndrome dos Cabelos Torcidos/tratamento farmacológico
Compostos Organometálicos/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cation Transport Proteins); 0 (Organometallic Compounds); 4QD397987E (Histidine); 9078K3MO9U (copper histidine); EC 3.6.1.- (Adenosine Triphosphatases); EC 3.6.3.54 (ATP7A protein, human); EC 3.6.3.54 (Copper-transporting ATPases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150316
[St] Status:MEDLINE


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[PMID]:27631241
[Au] Autor:Weng SC; Hsu CH; Wang NL; Lin SP; Jiang CB
[Ad] Endereço:aDepartment of Pediatric Gastroenterology, Hepatology and Nutrition bDepartment of Neonatology cDepartment of Pediatric General Surgery and Urology dDepartment of Genetics and Metabolism, MacKay Children's Hospital, Taipei eDepartment of Medicine, MacKay Medical College, New Taipei City fDivision of Biochemical Genetics, Department of Medical Research, MacKay Memorial Hospital gDepartment of Early Childhood Care, National Taipei University of Nursing and Health Sciences hMacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.
[Ti] Título:Recurrent spontaneous subserosal hematoma of ileum causing intestinal obstruction in a patient with menkes disease: A case report.
[So] Source:Medicine (Baltimore);95(37):e4842, 2016 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Menkes disease (MD) is a disorder of copper metabolism due to ATP7A gene mutation that leads to severe copper deficiency. Deformed blood vessels can be found in many parts of the body, and intracranial hematoma is generally reported. METHODS: We report a Taiwanese boy with MD who had recurrent spontaneous subserosal hematoma of ileum presenting as intestinal obstruction, with the 2 episodes 23 months apart. The patient returned to the usual physical status after surgical removal of the hematoma. RESULTS: The defective copper metabolism causes dysfunction of a plenty of copper-dependent enzymes, giving rise to unique kinky hair appearance, progressive neurodegeneration, and connective tissue abnormalities. To our knowledge, this is the first report on recurrent subserosal hemorrhage of intestine in MD. CONCLUSION: Owing to the fragile structure of blood vessels, subserosal hematoma should be considered when patients with MD having intestinal obstruction.
[Mh] Termos MeSH primário: Hematoma/complicações
Doenças do Íleo/etiologia
Obstrução Intestinal/etiologia
Síndrome dos Cabelos Torcidos/complicações
[Mh] Termos MeSH secundário: Pré-Escolar
Seres Humanos
Masculino
Recidiva
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004842


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[PMID]:27609945
[Au] Autor:Wacks NP; Schoppel K; Sell PJ; Guggina T
[Ad] Endereço:Family Medicine Residency Program.
[Ti] Título:Opening Pandora's Box: A Chest Radiograph in a 5-Month-Old With Bronchiolitis.
[So] Source:Hosp Pediatr;6(10):642-645, 2016 10.
[Is] ISSN:2154-1663
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bronquiolite/diagnóstico
Maus-Tratos Infantis
Síndrome dos Cabelos Torcidos
Administração dos Cuidados ao Paciente
Radiografia Torácica/métodos
Fraturas das Costelas
[Mh] Termos MeSH secundário: Maus-Tratos Infantis/diagnóstico
Maus-Tratos Infantis/ética
Maus-Tratos Infantis/terapia
Diagnóstico Diferencial
Seres Humanos
Achados Incidentais
Lactente
Masculino
Síndrome dos Cabelos Torcidos/diagnóstico
Síndrome dos Cabelos Torcidos/fisiopatologia
Síndrome dos Cabelos Torcidos/terapia
Administração dos Cuidados ao Paciente/ética
Administração dos Cuidados ao Paciente/métodos
Valor Preditivo dos Testes
Fraturas das Costelas/diagnóstico por imagem
Fraturas das Costelas/etiologia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


  10 / 953 MEDLINE  
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[PMID]:27455805
[Au] Autor:Shimizu N
[Ti] Título:[Copper metabolism and genetic disorders].
[So] Source:Nihon Rinsho;74(7):1151-5, 2016 Jul.
[Is] ISSN:0047-1852
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Copper is one of essential trace elements. Copper deficiency lead to growth and developmental failure and/or neurological dysfunction. However, excess copper is also problems for human life. There are two disorders of inborn error of copper metabolism, Menkes disease and Wilson disease. Menkes disease is an X linked recessive disorder with copper deficiency and Wilson disease is an autosomal recessive disorder with copper accumulation. These both disorders result from the defective functioning of copper transport P-type ATPase, ATP7A of Menkes disease and ATP7B of Wilson disease. In this paper, the author describes about copper metabolism of human, and clinical feature, diagnosis and treatment of Menkes disease and Wilson disease.
[Mh] Termos MeSH primário: Cobre/metabolismo
Predisposição Genética para Doença
Degeneração Hepatolenticular/metabolismo
Síndrome dos Cabelos Torcidos/metabolismo
[Mh] Termos MeSH secundário: Degeneração Hepatolenticular/diagnóstico
Degeneração Hepatolenticular/tratamento farmacológico
Degeneração Hepatolenticular/genética
Seres Humanos
Síndrome dos Cabelos Torcidos/diagnóstico
Síndrome dos Cabelos Torcidos/tratamento farmacológico
Síndrome dos Cabelos Torcidos/genética
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
789U1901C5 (Copper)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE



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