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[PMID]:28462392
[Au] Autor:Li WC; Zhu XY; Ritson E
[Ad] Endereço:University of St Andrews, St Andrews, Fife KY16 9JP, Scotland.
[Ti] Título:Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behavior in a simple vertebrate, the tadpole. We find that concussion-like behavior can be reliably induced by the mechanosensory stimulation of the head skin without direct physical impacts on the brain. Head skin stimulation activates a cholinergic pathway which then opens G protein-coupled inward-rectifying potassium channels (GIRKs) via postsynaptic M muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion. We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head.
[Mh] Termos MeSH primário: Acetilcolina/metabolismo
Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G/metabolismo
Neurônios/metabolismo
Receptores Muscarínicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Concussão Encefálica/metabolismo
Tronco Encefálico/metabolismo
Seres Humanos
Oócitos/metabolismo
Vertebrados/metabolismo
Xenopus laevis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (G Protein-Coupled Inwardly-Rectifying Potassium Channels); 0 (Receptors, Muscarinic); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29406639
[Au] Autor:Gillooly D
[Ti] Título:Current Recommendations on Management of Pediatric Concussions.
[So] Source:Pediatr Nurs;42(5):217-22, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Concussions are a form of traumatic brain injury (TBI). Concussion is defined by the American Academy of Neurology as a "trauma-induced alteration in mental status that may or may not involve loss of consciousness" (Kirkwood, Yeates, & Wilson, 2012, p. 1360). At least 1.7 million TBIs occur annually, with 75% being in the form of concussion. Almost half a million patients ages 14 years and younger visit emergency rooms annually for TBI (Centers for Disease Control and Prevention [CDC], 2011). Diagnosing a concussion can be difficult because symptoms vary among individuals and may be subtle and vague, and neuro-radiologic imaging studies typically reveal no abnormalities. Due to the varying degree of symptomatology and recovery, there are no specific recommendations on when it is safe for patients to resume normal activity. Complications can arise if a second injury occurs prior to complete healing from the initial concussion. This literature review identifies current recommendations on the screening and management of concussion in the pediatric population. A clear, concise definition of concussion is presented, as well as recommendations for concussion management. Return to play and return to learn guidelines are explored. The nursing role in concussion management is discussed, and future implications are explored.
[Mh] Termos MeSH primário: Concussão Encefálica/enfermagem
Papel do Profissional de Enfermagem
Enfermagem Pediátrica/educação
Enfermagem Pediátrica/normas
[Mh] Termos MeSH secundário: Adulto
Criança
Pré-Escolar
Educação Continuada em Enfermagem
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Guias de Prática Clínica como Assunto
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28094682
[Au] Autor:Caron JG; Rathwell S; Delaney JS; Johnston KM; Ptito A; Bloom GA
[Ad] Endereço:a Department of Kinesiology and Physical Education , McGill University , Montreal , QC , Canada.
[Ti] Título:Development, implementation and assessment of a concussion education programme for high school student-athletes.
[So] Source:J Sports Sci;36(1):48-55, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although experts have noted that adolescent athletes should be educated about concussions to improve their safety, there is no agreement on the most effective strategy to disseminate concussion education. The purpose of this study was to develop, implement and assess a concussion education programme. More precisely, four interactive oral presentations were delivered to high school student-athletes (N = 35, M = 15.94, SD = 0.34) in a large urban centre. Participants completed a questionnaire at three time-points during the season to measure changes in their knowledge (CK) and attitudes (CA) of concussions, and focus group interviews were conducted following the concussion education programme. Questionnaire data revealed participants' post-intervention CK scores were higher than their pre-intervention scores. During the focus groups, the student-athletes said they acquired CK about the role of protective equipment and symptom variability, and in terms of CA, they intended to avoid dangerous in-game collisions in the future. Our study was the first to create and deliver a concussion education intervention across multiple time-points, and to use mixed-methods in its assessment. These findings may be of interest to researchers, practitioners and stakeholders in sport who are invested in making the sport environment safer through concussion education and awareness.
[Mh] Termos MeSH primário: Atletas/psicologia
Traumatismos em Atletas/prevenção & controle
Concussão Encefálica/prevenção & controle
Conhecimentos, Atitudes e Prática em Saúde
Educação Física e Treinamento/métodos
[Mh] Termos MeSH secundário: Adolescente
Feminino
Grupos Focais
Dispositivos de Proteção da Cabeça
Seres Humanos
Masculino
Desenvolvimento de Programas
Avaliação de Programas e Projetos de Saúde
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1280180


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[PMID]:28449903
[Au] Autor:Suzuki Y; Khoury S; El-Khatib H; Chauny JM; Paquet J; Giguère JF; Denis R; Gosselin N; Lavigne GJ; Arbour C
[Ad] Endereço:Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada; Faculty of Dental Medicine, Université de Montréal, Montreal, Quebec, Canada.
[Ti] Título:Individuals with pain need more sleep in the early stage of mild traumatic brain injury.
[So] Source:Sleep Med;33:36-42, 2017 May.
[Is] ISSN:1878-5506
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hypersomnia is frequently reported after mild traumatic brain injury (mTBI), but its cause(s) remain elusive. This study examined sleep/wake activity after mTBI and its association with pain, a comorbidity often associated with insomnia. METHODS: Actigraphy recording was performed for 7 ± 2 consecutive days in 56 individuals at one month post-mTBI (64% male; 38 ± 12 years), 24 individuals at one year post-mTBI (58% male; 44 ± 11years), and in 20 controls (50% male; 37 ± 12 years). Pain intensity and its effect on quality of life was assessed with a visual analogue scale and the Short Form Health Survey (SF-36) bodily pain subscale. RESULTS: Overall, few differences in sleep/wake patterns were found between mTBI patients and controls. However, higher percentages of mTBI individuals with moderate-to-severe pain were found to require more than eight hours of sleep per day (37% vs11%; p = 0.04) and to be frequent nappers (defined as those who took three or more naps per week) (42% vs 22%; p = 0.04) compared to those with mild or no pain at one month postinjury. Correcting for age and depression, The SF-36 score was found to be a significant predictor of sleep duration exceeding eight hours per day at one month (odds ratio = 0.95; 95% confidence interval = 0.92-0.99; p = 0.01), but not at one year post-mTBI. Pain and increased sleep need (in terms of hours per day or napping frequency) were found to co-exist in as much as 29% of mTBI patients at one month postinjury. CONCLUSION: Pain could be associated with more pronounced sleep need in about one-third of mTBI patients during early recovery. Unalleviated pain, found in more than 60% of mTBI patients, should therefore be looked for in all mTBI patients reporting new onset of sleep disorder, not only in those with insomnia.
[Mh] Termos MeSH primário: Concussão Encefálica/complicações
Lesões Encefálicas/complicações
Distúrbios do Sono por Sonolência Excessiva/complicações
Dor/complicações
Transtornos do Sono-Vigília/complicações
Sono/fisiologia
[Mh] Termos MeSH secundário: Actigrafia/métodos
Adulto
Concussão Encefálica/epidemiologia
Concussão Encefálica/fisiopatologia
Lesões Encefálicas/epidemiologia
Comorbidade
Distúrbios do Sono por Sonolência Excessiva/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Dor/epidemiologia
Dor/fisiopatologia
Dor/psicologia
Estudos Prospectivos
Qualidade de Vida
Autorrelato
Índice de Gravidade de Doença
Distúrbios do Início e da Manutenção do Sono/complicações
Transtornos do Sono-Vigília/epidemiologia
Transtornos do Sono-Vigília/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29390491
[Au] Autor:Jang SH; Seo JP
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Taegu, Republic of Korea.
[Ti] Título:Absent-mindedness and injury of the ascending reticular activating system in a patient with mild traumatic brain injury: A case report.
[So] Source:Medicine (Baltimore);96(51):e9289, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: No study on the association of absent-mindedness and injury of the ascending reticular activating system (ARAS) has been reported. We report on a patient who showed absent-mindedness and injury of the ARAS following mild traumatic brain injury. PATIENT CONCERNS: The patient complained of absent-mindedness since the head trauma, which was mainly observed while dining for several (5-10) minutes approximately 3 to 4 times a day: according to the patient's family, he usually stopped eating while holding the spoon in the air for approximately 5∼10 minutes. DIAGNOSES: A 19-year-old man suffered from head trauma resulting from being hit on his head by a falling glass from a large window (1.5 × 2 m, approximately 100 kg) at a cafe. INTERVENTIONS: His absent-mindedness showed slow improvement with the passage of time and had almost disappeared at seven months after onset. OUTCOMES: The lower portion of both lower dorsal ARAS and the upper portion of the left lower ventral ARAS of the patient were thinner, and partial tearing was observed in the right lower ventral ARAS. Decreased neural connectivity of the intralaminar thalamic nucleus to the prefrontal cortex, basal forebrain, parietal cortex, and occipital cortex was detected in both hemispheres. LESSONS: Injury of the ARAS and injury of the cerebral cortex was demonstrated in a patient with absent-mindedness following mild traumatic brain injury. The absent-mindedness in this patient might be related to the injury of the ARAS.
[Mh] Termos MeSH primário: Concussão Encefálica/complicações
Traumatismos Craniocerebrais/complicações
Núcleos Intralaminares do Tálamo/lesões
Transtornos da Memória/etiologia
[Mh] Termos MeSH secundário: Concussão Encefálica/diagnóstico
Córtex Cerebral/lesões
Traumatismos Craniocerebrais/diagnóstico por imagem
Seguimentos
Seres Humanos
Escala de Gravidade do Ferimento
Masculino
Transtornos da Memória/fisiopatologia
Testes Neuropsicológicos
Índice de Gravidade de Doença
Fatores de Tempo
Tomografia Computadorizada de Emissão de Fóton Único/métodos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009289


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[PMID]:29390470
[Au] Autor:Jang SH; Seo JP
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namgu, Daegu, Republic of Korea.
[Ti] Título:Delayed degeneration of the left fornical crus with verbal memory impairment in a patient with mild traumatic brain injury: A case report.
[So] Source:Medicine (Baltimore);96(51):e9219, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a patient who showed delayed degeneration of the left fornical crus with verbal memory impairment following mild traumatic brain injury (TBI), which was demonstrated by diffusion tensor tractography (DTT). PATIENT CONCERNS:: fter flexion and hyperextension of her head to the opposite side, the patient experienced a dazed feeling for a while at the time of head trauma. The patient's Glasgow Coma Scale score was 15, and mini-mental state examination score was 30. DIAGNOSES: A 50-year-old right-handed female with 12 years of education suffered from head trauma resulting from a car accident. INTERVENTIONS: A The patient showed normal memory function at one year after onset: the Memory Assessment Scale (global memory: 124 (95 percentile (%ile)), verbal memory: 111 (77%ile), and visual memory: 132 (98%ile) (A percentile is a measure used in statistics indicating the value below which a given percentage of observations in a group of observations fall). However, the patient began to experience decline of memory function such as forgetfulness at approximately 1.5 years after onset. On the 2-year evaluation, she showed decrement of memory function (global memory: 108 (70%ile), verbal memory: 86 (18%ile), and visual memory: 129 (97%ile). OUTCOMES: On 1-year DTT, the integrity of the fornix was well preserved between the fornical column and fornical crus. However, on 2-year DTT, a discontinuation was observed in the left fornical crus. LESSONS: Delayed degeneration of the left fornical crus was demonstrated in a patient who showed delayed onset of verbal memory impairment following mild TBI.
[Mh] Termos MeSH primário: Concussão Encefálica/complicações
Imagem de Tensor de Difusão/métodos
Fórnice/diagnóstico por imagem
Fórnice/fisiopatologia
Transtornos da Memória/etiologia
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Concussão Encefálica/diagnóstico
Progressão da Doença
Feminino
Seguimentos
Fórnice/lesões
Escala de Coma de Glasgow
Seres Humanos
Imagem por Ressonância Magnética/métodos
Transtornos da Memória/fisiopatologia
Meia-Idade
Testes Neuropsicológicos
República da Coreia
Medição de Risco
Fatores de Tempo
Comportamento Verbal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009219


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[PMID]:28455786
[Au] Autor:O'Connor KL; Peeters T; Szymanski S; Broglio SP
[Ad] Endereço:NeuroTrauma Research Laboratory, University of Michigan School of Kinesiology, Ann Arbor, MI, USA. kloconn@umich.edu.
[Ti] Título:Individual Impact Magnitude vs. Cumulative Magnitude for Estimating Concussion Odds.
[So] Source:Ann Biomed Eng;45(8):1985-1992, 2017 08.
[Is] ISSN:1573-9686
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Helmeted impact devices have allowed researchers to investigate the biomechanics of head impacts in vivo. While increased impact magnitude has been associated with greater concussion risk, a definitive concussive threshold has not been established. It is likely that concussion risk is not determined by a single impact itself, but a host of predisposing factors. These factors may include genetics, fatigue, and/or prior head impact exposure. The objective of the current paper is to investigate the association between cumulative head impact magnitude and concussion risk. It is hypothesized that increased cumulative magnitudes will be associated with greater concussion risk. This retrospective analysis included participants that were recruited from regional high-schools in Illinois and Michigan from 2007 to 2014 as part of an ongoing study on concussion biomechanics. Across seven seasons, 185 high school football athletes were instrumented with the Head Impact Telemetry system. Out of 185 athletes, 31 (17%) sustained a concussion, with two athletes sustaining two concussions over the study period, yielding 33 concussive events. The system recorded 78,204 impacts for all concussed players. Linear acceleration, rotational acceleration, and head impact telemetry severity profile (HITsp) magnitudes were summed within five timeframes: the day of injury, three days prior to injury, seven days prior to injury, 30 days prior to injury, and prior in-season exposure. Logistic regressions were modeled to explain concussive events based on the singular linear acceleration, rotational acceleration, and HITsp event along with the calculated summations over time. Linear acceleration, rotational acceleration, and HITsp all produced significant models estimating concussion (p < 0.05). The strongest estimators of a concussive impact were the linear acceleration (OR = 1.040, p < 0.05), rotational acceleration (OR = 1.001, p < 0.05), and HITsp (OR = 1.003, p < 0.05) for the singular impact rather than any of the cumulative magnitude calculations. Moreover, no cumulative count measure was significant for linear or rotational acceleration. Results from this investigation support the growing literature indicating cumulative magnitude is not related to concussion likelihood. Cumulative magnitude is a simplistic measure of the total exposure sustained by a player over a given period. However, this measure is limited as it assumes the brain is a static structure unable to undergo self-repair. Future research should consider how biological recovery between impacts may influence concussion risk.
[Mh] Termos MeSH primário: Aceleração
Concussão Encefálica/epidemiologia
Concussão Encefálica/fisiopatologia
Futebol Americano/lesões
Futebol Americano/estatística & dados numéricos
[Mh] Termos MeSH secundário: Traumatismos em Atletas/diagnóstico
Traumatismos em Atletas/epidemiologia
Traumatismos em Atletas/fisiopatologia
Concussão Encefálica/diagnóstico
Seres Humanos
Masculino
Michigan/epidemiologia
Razão de Chances
Prevalência
Prognóstico
Reprodutibilidade dos Testes
Medição de Risco/métodos
Sensibilidade e Especificidade
Estresse Mecânico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s10439-017-1843-3


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[PMID]:28742910
[Au] Autor:Mez J; Daneshvar DH; Kiernan PT; Abdolmohammadi B; Alvarez VE; Huber BR; Alosco ML; Solomon TM; Nowinski CJ; McHale L; Cormier KA; Kubilus CA; Martin BM; Murphy L; Baugh CM; Montenigro PH; Chaisson CE; Tripodis Y; Kowall NW; Weuve J; McClean MD; Cantu RC; Goldstein LE; Katz DI; Stern RA; Stein TD; McKee AC
[Ad] Endereço:Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, Massachusetts2Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
[Ti] Título:Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.
[So] Source:JAMA;318(4):360-370, 2017 07 25.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). Objective: To determine the neuropathological and clinical features of deceased football players with CTE. Design, Setting, and Participants: Case series of 202 football players whose brains were donated for research. Neuropathological evaluations and retrospective telephone clinical assessments (including head trauma history) with informants were performed blinded. Online questionnaires ascertained athletic and military history. Exposures: Participation in American football at any level of play. Main Outcomes and Measures: Neuropathological diagnoses of neurodegenerative diseases, including CTE, based on defined diagnostic criteria; CTE neuropathological severity (stages I to IV or dichotomized into mild [stages I and II] and severe [stages III and IV]); informant-reported athletic history and, for players who died in 2014 or later, clinical presentation, including behavior, mood, and cognitive symptoms and dementia. Results: Among 202 deceased former football players (median age at death, 66 years [interquartile range, 47-76 years]), CTE was neuropathologically diagnosed in 177 players (87%; median age at death, 67 years [interquartile range, 52-77 years]; mean years of football participation, 15.1 [SD, 5.2]), including 0 of 2 pre-high school, 3 of 14 high school (21%), 48 of 53 college (91%), 9 of 14 semiprofessional (64%), 7 of 8 Canadian Football League (88%), and 110 of 111 National Football League (99%) players. Neuropathological severity of CTE was distributed across the highest level of play, with all 3 former high school players having mild pathology and the majority of former college (27 [56%]), semiprofessional (5 [56%]), and professional (101 [86%]) players having severe pathology. Among 27 participants with mild CTE pathology, 26 (96%) had behavioral or mood symptoms or both, 23 (85%) had cognitive symptoms, and 9 (33%) had signs of dementia. Among 84 participants with severe CTE pathology, 75 (89%) had behavioral or mood symptoms or both, 80 (95%) had cognitive symptoms, and 71 (85%) had signs of dementia. Conclusions and Relevance: In a convenience sample of deceased football players who donated their brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE may be related to prior participation in football.
[Mh] Termos MeSH primário: Traumatismos em Atletas/patologia
Encéfalo/patologia
Encefalopatia Traumática Crônica/patologia
Futebol Americano/lesões
[Mh] Termos MeSH secundário: Adulto
Idoso
Atletas
Traumatismos em Atletas/complicações
Concussão Encefálica/epidemiologia
Causas de Morte
Encefalopatia Traumática Crônica/diagnóstico
Encefalopatia Traumática Crônica/etiologia
Transtornos Cognitivos/etiologia
Seres Humanos
Masculino
Transtornos Mentais/etiologia
Meia-Idade
Índice de Gravidade de Doença
Transtornos Relacionados ao Uso de Substâncias/etiologia
Estados Unidos
Proteínas tau/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (tau Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.8334


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[PMID]:28452602
[Au] Autor:Walter A; Finelli K; Bai X; Arnett P; Bream T; Seidenberg P; Lynch S; Johnson B; Slobounov S
[Ad] Endereço:a Penn State Center for Sport Concussion , Pennsylvania State University , University Park , Pennsylvania.
[Ti] Título:Effect of Enzogenol® Supplementation on Cognitive, Executive, and Vestibular/Balance Functioning in Chronic Phase of Concussion.
[So] Source:Dev Neuropsychol;42(2):93-103, 2017.
[Is] ISSN:1532-6942
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study examined the feasibility of Enzogenol® as a potential treatment modality for concussed individuals with residual symptoms in the chronic phase. Forty-two student-athletes with history of sport-related concussion were enrolled, comparing Enzogenol® versus placebo. Testing was conducted using virtual reality (VR) and electroencephalography (EEG), with neuropsychological (NP) tasks primarily used to induce cognitive challenges. After six weeks, the Enzogenol® group showed enhanced frontal-midline theta, and decreased parietal theta power, indicating reduced mental fatigue. Subjects enrolled in the Enzogenol® group also self-reported reduced mental fatigue and sleep problems. This suggests that Enzogenol® has the potential to improve brain functioning in the chronic phase of concussion.
[Mh] Termos MeSH primário: Traumatismos em Atletas/tratamento farmacológico
Concussão Encefálica/tratamento farmacológico
Cognição/efeitos dos fármacos
Função Executiva/efeitos dos fármacos
Flavonoides/uso terapêutico
Equilíbrio Postural/efeitos dos fármacos
Quercetina/análogos & derivados
[Mh] Termos MeSH secundário: Adolescente
Atletas
Traumatismos em Atletas/diagnóstico
Traumatismos em Atletas/psicologia
Concussão Encefálica/diagnóstico
Concussão Encefálica/psicologia
Eletroencefalografia
Feminino
Flavonoides/farmacologia
Seres Humanos
Masculino
Fadiga Mental/tratamento farmacológico
Fadiga Mental/psicologia
Testes Neuropsicológicos
Quercetina/farmacologia
Quercetina/uso terapêutico
Sono/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonoids); 0 (enzogenol); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/87565641.2016.1256404


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[PMID]:28452601
[Au] Autor:Salazar CL; Mulligan K; Webbe F
[Ad] Endereço:a Psychology , Florida Institute of Technology , Melbourne , Florida.
[Ti] Título:Updating the Rey Dot Counting Test for Use in Collegiate Baseline Concussion Testing.
[So] Source:Dev Neuropsychol;42(2):83-92, 2017.
[Is] ISSN:1532-6942
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Athletes occasionally attempt to lower their baseline scores to mask the effects of a concussion during post-trauma assessment, a phenomenon known as sandbagging. In order to help prevent this from occurring, the Rey Dot Counting Test (DCT) was examined as a potential measure to be added to a Division II university screening battery. Investigators utilized samples of athletes at baseline and non-athlete students instructed to provide honest effort or suppressed effort, either naïvely or coached. The results support the use of the DCT as a valid measure of suboptimal performance when using modified norms established from collegiate populations.
[Mh] Termos MeSH primário: Traumatismos em Atletas/diagnóstico
Concussão Encefálica/diagnóstico
Testes Neuropsicológicos
[Mh] Termos MeSH secundário: Atletas
Traumatismos em Atletas/psicologia
Concussão Encefálica/psicologia
Feminino
Seres Humanos
Masculino
Estudantes
Universidades
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/87565641.2017.1303701



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