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  1 / 23 MEDLINE  
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[PMID]:28847125
[Au] Autor:Khalili H; Derakhshan N; Ghaffarpasand F; Heydari ST
[Ad] Endereço:Neurosurgery Department, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:In Reply to the Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries: A Randomized Double-Blind Placebo-Controlled Clinical Trial".
[So] Source:World Neurosurg;105:1021, 2017 09.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Método Duplo-Cego
Glibureto
[Mh] Termos MeSH secundário: Contusão Encefálica
Lesões Encefálicas
Lesões Encefálicas Traumáticas
Contusões
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
SX6K58TVWC (Glyburide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  2 / 23 MEDLINE  
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[PMID]:28847124
[Au] Autor:Garg K; Singh PM
[Ad] Endereço:Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India. Electronic address: kanwaljeet84@gmail.com.
[Ti] Título:Letter to the Editor Regarding "Effects of Oral Glibenclamide on Brain Contusion Volume and Functional Outcome of Patients with Moderate and Severe Traumatic Brain Injuries: A Randomized Double-Blind Placebo-Controlled Clinical Trial".
[So] Source:World Neurosurg;105:1020, 2017 09.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Método Duplo-Cego
Glibureto
[Mh] Termos MeSH secundário: Contusão Encefálica
Lesões Encefálicas
Lesões Encefálicas Traumáticas
Contusões
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
SX6K58TVWC (Glyburide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  3 / 23 MEDLINE  
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[PMID]:28435118
[Au] Autor:Samuthrat T; Ye K; Tong Y
[Ad] Endereço:Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
[Ti] Título:Transoral Intracranial Injury via Middle Skull Base by a Blunt Chopstick in a Child.
[So] Source:World Neurosurg;103:952.e11-952.e17, 2017 Jul.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transoral penetrating injury from a blunt-tipped chopstick is unusual and should be promptly dealt with because it is associated with high morbidity and mortality. CASE DESCRIPTION: We report a case of a 2-year-old girl who sustained a transoral penetrating brain injury after falling onto a bamboo chopstick, which penetrated through the hard palate and eventually led to middle skull base fracture as well as temporal lobe laceration and contusion. The chopstick was successfully extracted via a transoral approach followed by administration of empirical antibiotics and anticonvulsants. The postoperative course was uneventful, and a 2-year follow-up evaluation revealed a favorable outcome. CONCLUSIONS: Preoperative and postoperative imaging and extensive monitoring of the patient's condition are mandatory for evaluation of possible development of complications. An optimal result can be obtained by a tailored management and treatment approach for each specific patient.
[Mh] Termos MeSH primário: Contusão Encefálica/diagnóstico por imagem
Lesões Encefálicas Traumáticas/diagnóstico por imagem
Lesões Encefálicas/diagnóstico por imagem
Encéfalo/diagnóstico por imagem
Corpos Estranhos/diagnóstico por imagem
Traumatismos Cranianos Penetrantes/diagnóstico por imagem
Base do Crânio/diagnóstico por imagem
Fraturas Cranianas/diagnóstico por imagem
Lobo Temporal/lesões
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Corpos Estranhos/cirurgia
Seres Humanos
Base do Crânio/lesões
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  4 / 23 MEDLINE  
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[PMID]:27923323
[Au] Autor:Zhao CC; Wang CF; Li WP; Lin Y; Tang QL; Feng JF; Mao Q; Gao GY; Jiang JY
[Ad] Endereço:1 Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai Institute of Head Trauma, Shanghai, People's Republic of China .
[Ti] Título:Mild Hypothermia Promotes Pericontusion Neuronal Sprouting via Suppressing Suppressor of Cytokine Signaling 3 Expression after Moderate Traumatic Brain Injury.
[So] Source:J Neurotrauma;34(8):1636-1644, 2017 Apr 15.
[Is] ISSN:1557-9042
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mild therapeutic hypothermia is a candidate for the treatment of traumatic brain injury (TBI). However, the role of mild hypothermia in neuronal sprouting after TBI remains obscure. We used a fluid percussion injury (FPI) model to assess the effect of mild hypothermia on pericontusion neuronal sprouting after TBI in rats. Male Sprague-Dawley rats underwent FPI or sham surgery, followed by mild hypothermia treatment (33°C) or normothermia treatment (37°C) for 3 h. All the rats were euthanized at 7 days after FPI. Neuronal sprouting that was confirmed by an increase in growth associated protein-43 (GAP-43) expression was evaluated using immunofluorescence and Western blot assays. The expression levels of several intrinsic and extrinsic sprouting-associated genes such as neurite outgrowth inhibitor A (NogoA), phosphatase and tensin homolog (PTEN), and suppressor of cytokine signaling 3 (SOCS3) were analyzed by quantitative real-time polymerase chain reaction (RT-PCR). Our results revealed that mild hypothermia significantly increased the expression level of GAP-43 and dramatically suppressed the expression level of interleukin-6 (IL-6) and SOCS3 at 7 days after FPI in the ipsilateral cortex compared with that of the normothermia TBI group. These data suggest that post-traumatic mild hypothermia promotes pericontusion neuronal sprouting after TBI. Moreover, the mechanism of hypothermia-induced neuronal sprouting might be partially associated with decreased levels of SOCS3.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/metabolismo
Lesões Encefálicas Traumáticas/terapia
Córtex Cerebral/metabolismo
Proteína GAP-43/metabolismo
Hipotermia Induzida/métodos
Interleucina-6/metabolismo
Neurônios/metabolismo
Proteína 3 Supressora da Sinalização de Citocinas/metabolismo
[Mh] Termos MeSH secundário: Animais
Contusão Encefálica/metabolismo
Contusão Encefálica/terapia
Modelos Animais de Doenças
Masculino
Proteínas Nogo/metabolismo
PTEN Fosfo-Hidrolase/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GAP-43 Protein); 0 (Interleukin-6); 0 (Nogo Proteins); 0 (Socs3 protein, rat); 0 (Suppressor of Cytokine Signaling 3 Protein); EC 3.1.3.67 (PTEN Phosphohydrolase); EC 3.1.3.67 (Pten protein, rat)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1089/neu.2016.4759


  5 / 23 MEDLINE  
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[PMID]:27903013
[Au] Autor:Korf EM; Tronnier VM; Gliemroth J; Küchler JN
[Ad] Endereço:Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany.
[Ti] Título:Isoflurane-Associated Mydriasis Mimicking Blown Pupils in a Patient Treated in a Neurointensive Care Unit.
[So] Source:J Neurol Surg A Cent Eur Neurosurg;78(4):403-406, 2017 Jul.
[Is] ISSN:2193-6323
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We report a misinterpretation of bilateral mydriasis as blown pupils related to elevated intracranial pressure (ICP) under volatile sedation with isoflurane (Anesthetic Conserving Device [AnaConDa], Hudson RCI, Uppland Vasby, Sweden) in a 59-year-old patient with a severe traumatic brain injury with frontal contusion. The patient showed bilateral mydriasis and a missing light reflex 8 hours after changing sedation from intravenous treatment with midazolam and esketamine to volatile administration of isoflurane. Because cranial computed tomography ruled out signs of cerebral herniation, we assumed the bilateral mydriasis was caused by isoflurane and reduced the isoflurane supply. Upon this reduction the mydriasis regressed, suggesting the observed mydriasis was related to an overdose of isoflurane. Intensivists should be aware of the reported phenomenon to avoid unnecessary diagnostic investigations that might harm the patient. We recommend careful control of the isoflurane dose when fixed and dilated pupils appear in patients without other signs of elevated ICP.
[Mh] Termos MeSH primário: Anestésicos Inalatórios/efeitos adversos
Lesões Encefálicas Traumáticas/terapia
Sedação Profunda
Hipertensão Intracraniana/diagnóstico
Isoflurano/efeitos adversos
Midríase/induzido quimicamente
[Mh] Termos MeSH secundário: Contusão Encefálica/complicações
Contusão Encefálica/tratamento farmacológico
Contusão Encefálica/terapia
Lesões Encefálicas Traumáticas/complicações
Lesões Encefálicas Traumáticas/tratamento farmacológico
Cuidados Críticos
Diagnóstico Diferencial
Lobo Frontal
Seres Humanos
Hipertensão Intracraniana/etiologia
Masculino
Meia-Idade
Midríase/etiologia
Respiração Artificial
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1594237


  6 / 23 MEDLINE  
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[PMID]:27799012
[Au] Autor:Szczygielski J; Müller A; Mautes AE; Sippl C; Glameanu C; Schwerdtfeger K; Steudel WI; Oertel J
[Ad] Endereço:1 Department of Neurosurgery, Saarland University Medical Center and Saarland University Faculty of Medicine , Homburg/Saar, Germany .
[Ti] Título:Selective Brain Hypothermia Mitigates Brain Damage and Improves Neurological Outcome after Post-Traumatic Decompressive Craniectomy in Mice.
[So] Source:J Neurotrauma;34(8):1623-1635, 2017 Apr 15.
[Is] ISSN:1557-9042
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypothermia and decompressive craniectomy (DC) have been considered as treatment for traumatic brain injury. The present study investigates whether selective brain hypothermia added to craniectomy could improve neurological outcome after brain trauma. Male CD-1 mice were assigned into the following groups: sham; DC; closed head injury (CHI); CHI followed by craniectomy (CHI+DC); and CHI+DC followed by focal hypothermia (CHI+DC+H). At 24 h post-trauma, animals were subjected to Neurological Severity Score (NSS) test and Beam Balance Score test. At the same time point, magnetic resonance imaging using a 9.4 Tesla scanner and subsequent volumetric evaluation of edema and contusion were performed. Thereafter, the animals were sacrificed and subjected to histopathological analysis. According to NSS, there was a significant impairment among all the groups subjected to trauma. Animals with both trauma and craniectomy performed significantly worse than animals with craniectomy alone. This deleterious effect disappeared when additional hypothermia was applied. BBS was significantly worse in the CHI and CHI+DC groups, but not in the CHI+DC+H group, compared to the sham animals. Edema and contusion volumes were significantly increased in CHI+DC animals, but not in the CHI+DC+H group, compared to the DC group. Histopathological analysis showed that neuronal loss and contusional blossoming could be attenuated by application of selective brain hypothermia. Selective brain cooling applied post-trauma and craniectomy improved neurological function and reduced structural damage and may be therefore an alternative to complication-burdened systemic hypothermia. Clinical studies are recommended in order to explore the potential of this treatment.
[Mh] Termos MeSH primário: Edema Encefálico/terapia
Lesões Encefálicas Traumáticas/terapia
Craniectomia Descompressiva/métodos
Hipotermia Induzida/métodos
[Mh] Termos MeSH secundário: Animais
Contusão Encefálica/diagnóstico por imagem
Contusão Encefálica/terapia
Edema Encefálico/diagnóstico por imagem
Lesões Encefálicas Traumáticas/diagnóstico por imagem
Terapia Combinada
Imagem por Ressonância Magnética
Masculino
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE
[do] DOI:10.1089/neu.2016.4615


  7 / 23 MEDLINE  
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[PMID]:27473209
[Au] Autor:Allison RZ; Nakagawa K; Hayashi M; Donovan DJ; Koenig MA
[Ad] Endereço:Division of Neurosurgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
[Ti] Título:Derivation of a Predictive Score for Hemorrhagic Progression of Cerebral Contusions in Moderate and Severe Traumatic Brain Injury.
[So] Source:Neurocrit Care;26(1):80-86, 2017 Feb.
[Is] ISSN:1556-0961
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUNDS: After traumatic brain injury (TBI), hemorrhagic progression of contusions (HPCs) occurs frequently. However, there is no established predictive score to identify high-risk patients for HPC. METHODS: Consecutive patients who were hospitalized (2008-2013) with non-penetrating moderate or severe TBI were studied. The primary outcome was HPC, defined by both a relative increase in contusion volume by ≥30 % and an absolute increase by ≥10 mL on serial imaging. Logistic regression models were created to identify independent risk factors for HPC. The HPC Score was then derived based on the final model. RESULTS: Among a total of 286 eligible patients, 61 (21 %) patients developed HPC. On univariate analyses, HPC was associated with older age, higher initial blood pressure, antiplatelet medications, anticoagulants, subarachnoid hemorrhage (SAH) subdural hematoma (SDH), skull fracture, frontal contusion, larger contusion volume, and shorter interval from injury to initial CT. In the final model, SAH (OR 6.33, 95 % CI, 1.80-22.23), SDH (OR 3.46, 95 % CI, 1.39-8.63), and skull fracture (OR 2.67, 95 % CI, 1.28-5.58) were associated with HPC. Based on these factors, the HPC Score was derived (SAH = 2 points, SDH = 1 point, and skull fracture = 1 point). This score had an area under the receiver operating curve of 0.77. Patients with a score of 0-2 had a 4.0 % incidence of HPC, while patients with a score of 3-4 had a 34.6 % incidence of HPC. CONCLUSIONS: A simple HPC Score was developed for early risk stratification of HPC in patients with moderate or severe TBI.
[Mh] Termos MeSH primário: Contusão Encefálica/diagnóstico
Lesões Encefálicas Traumáticas/diagnóstico
Progressão da Doença
Hemorragias Intracranianas/diagnóstico
Medição de Risco/métodos
Fraturas Cranianas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Contusão Encefálica/etiologia
Contusão Encefálica/terapia
Lesões Encefálicas Traumáticas/complicações
Lesões Encefálicas Traumáticas/terapia
Seres Humanos
Hemorragias Intracranianas/etiologia
Hemorragias Intracranianas/terapia
Meia-Idade
Prognóstico
Índice de Gravidade de Doença
Fraturas Cranianas/complicações
Fraturas Cranianas/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE
[do] DOI:10.1007/s12028-016-0303-5


  8 / 23 MEDLINE  
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[PMID]:27759956
[Au] Autor:Chio CC; Lin MT; Chang CP; Lin HJ
[Ad] Endereço:Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
[Ti] Título:A positive correlation exists between neurotrauma and TGF-ß1-containing microglia in rats.
[So] Source:Eur J Clin Invest;46(12):1063-1069, 2016 Dec.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transforming growth factor-beta 1 (TGF-ß1) regulates many processes after traumatic brain injury (TBI). Both Neuro AiD™ (MLC601) and astragaloside (AST) attenuate microglia activation in rats with TBI. The purpose of this study was to investigate whether MLC601 or AST improves output of TBI by affecting microglial expression of TGF-ß1. MATERIALS AND METHODS: Adult male Sprague-Dawley rats (120 in number) were used to investigate the contribution of TGF-ß1-containing microglia in the MLC601-mediated or the AST-mediated neuroprotection in the brain trauma condition using lateral fluid percussion injury. RESULTS: Pearson correlation analysis revealed that there was a positive correlation between brain injury (evidenced by both brain contused volume and neurological severity score) and the cortical numbers of TGF-ß1-containing microglia for the rats (n = 12) 4 days post-TBI. MLC601 or AST significantly (P < 0·05) attenuated TBI-induced brain contused volume (119 ± 14 mm or 108 ± 11 mm vs. 160 ± 21 mm ), neurological severity score (7·8 ± 0·3 or 8·1 ± 0·4 vs. 10·2 ± 0·5) and numbers of TGF-ß1-containing microglia (6% ± 2% or 11% ± 3% vs. 79% ± 7%) for the rats 4 days post-TBI. CONCLUSIONS: There was a positive correlation between TBI and cortical numbers of TGF-ß1-containing microglia which could be significantly attenuated by astragaloside or NeuroAiD™ (MLC601) in rats.
[Mh] Termos MeSH primário: Contusão Encefálica/metabolismo
Lesões Encefálicas Traumáticas/metabolismo
Encéfalo/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Microglia/efeitos dos fármacos
Saponinas/farmacologia
Fator de Crescimento Transformador beta1/efeitos dos fármacos
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Encéfalo/patologia
Contusão Encefálica/patologia
Contusão Encefálica/fisiopatologia
Lesões Encefálicas Traumáticas/patologia
Lesões Encefálicas Traumáticas/fisiopatologia
Modelos Animais de Doenças
Imuno-Histoquímica
Masculino
Microglia/metabolismo
Microglia/patologia
Ratos
Ratos Sprague-Dawley
Fator de Crescimento Transformador beta1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Neuroaid); 0 (Saponins); 0 (Tgfb1 protein, mouse); 0 (Transforming Growth Factor beta1); 0 (Triterpenes); 3A592W8XKE (astragaloside A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12693


  9 / 23 MEDLINE  
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[PMID]:27592473
[Au] Autor:Zhang D; Teng J
[Ad] Endereço:Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Jianshe East Road, Jinshui District, Zhengzhou City, Henan, China.
[Ti] Título:Nrf2 knockout: The effect on neurological dysfunction and the activation of glial cells of mice after brain injury.
[So] Source:Pak J Pharm Sci;29(4 Suppl):1365-9, 2016 Jul.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:To investigate the protective role and possible mechanisms of Nrf2 gene in cerebral trauma in mice. The types Nrf2(-/-) and Nrf2(+/+) mice were confirmed by PCR, and the model of closed head injury was established. The severity of injury and the effect of the injury on neurological status were assessed by Neurological Severity Score (NSS) and fatality rate, and the activated conditions of microglia and astrocyte around the injured area were observed by immunohistochemical method. Compared with Nrf2(+/+) mice, the nerve dysfunction of the Nrf2(-/-) mice was obviously more severe (P<0.01). On the first day after injury, the activation of microglia around the injured area increased significantly in Nrf2 (-/-) mice, the difference was more significant on the third day, and there was still statistical difference until the 7th day (P<0.05). Moreover, On the days 1, 3, 7 after injury, the activation of astrocyte around the injured area also increased in Nrf2(-/-) mice, however, there was statistical difference only on the 3rd day (P<0.05). Nrf2 gene knockout can aggravate the nerve dysfunction after cerebral trauma, and this effect is achieved, at least partly, possibly via the effect of Nrf2 on glial activation.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/genética
Lesões Encefálicas Traumáticas/patologia
Ativação de Macrófagos/genética
Fator 2 Relacionado a NF-E2/genética
Doenças do Sistema Nervoso/genética
Neuroglia
[Mh] Termos MeSH secundário: Animais
Astrócitos/patologia
Contusão Encefálica/genética
Contusão Encefálica/patologia
Lesões Encefálicas Traumáticas/mortalidade
Imuno-Histoquímica
Masculino
Camundongos
Camundongos Endogâmicos ICR
Camundongos Knockout
Doenças do Sistema Nervoso/mortalidade
Doenças do Sistema Nervoso/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160905
[St] Status:MEDLINE


  10 / 23 MEDLINE  
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[PMID]:27591733
[Au] Autor:Sparvero LJ; Amoscato AA; Fink AB; Anthonymuthu T; New LA; Kochanek PM; Watkins S; Kagan VE; Bayir H
[Ad] Endereço:Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
[Ti] Título:Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury.
[So] Source:J Neurochem;139(4):659-675, 2016 Nov.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Traumatic brain injury (TBI) leads to changes in ion fluxes, alterations in mitochondrial function, and increased generation of reactive oxygen species, resulting in secondary tissue damage. Mitochondria play important signaling roles in coordination of multiple metabolic platforms in addition to their well-known role in bioenergetics. Mitochondrial signaling strongly depends on cardiolipin (CL), a mitochondria-specific structurally unusual anionic phospholipid containing four fatty acyl chains. While our previous reports indicated that CL is selectively oxidized and presents itself as a target for the redox therapy following TBI, the topography of changes of CL in the injured brain remained to be defined. Here, we present a matrix-assisted laser desorption/ionization imaging study which reports regio-specific changes in CL, in a controlled cortical impact model of TBI in rats. Matrix-assisted laser desorption/ionization imaging revealed that TBI caused early decreases in CL in the contusional cortex, ipsilateral hippocampus, and thalamus with the most highly unsaturated CL species being most susceptible to loss. Phosphatidylinositol was the only other lipid species that exhibited a significant decrease, albeit to a lesser extent than CL. Signals for other lipids remained unchanged. This is the first study evaluating the spatial distribution of CL loss after acute brain injury. We propose that the CL loss may constitute an upstream mechanism for CL-driven signaling in different brain regions as an early response mechanism and may also underlie the bioenergetic changes that occur in hippocampal, cortical, and thalamic mitochondria after TBI.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/diagnóstico por imagem
Cardiolipinas
Córtex Cerebral/diagnóstico por imagem
Hipocampo/diagnóstico por imagem
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Tálamo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Animais
Contusão Encefálica/diagnóstico por imagem
Contusão Encefálica/metabolismo
Lesões Encefálicas Traumáticas/metabolismo
Cardiolipinas/metabolismo
Córtex Cerebral/metabolismo
Hipocampo/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Tálamo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiolipins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160904
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.13840



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