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[PMID]:29394920
[Au] Autor:Vanikieti K; Poonyathalang A; Jindahra P; Cheecharoen P; Chokthaweesak W
[Ad] Endereço:Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Bangkok, 10400, Thailand.
[Ti] Título:Occipital lobe infarction: a rare presentation of bilateral giant cavernous carotid aneurysms: a case report.
[So] Source:BMC Ophthalmol;18(1):25, 2018 Feb 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses in the ICA wall, secondary to systemic hypertension. CCAs are considered benign lesions, given the low risk for developing major neurologic morbidities (i.e., subarachnoid hemorrhage, cerebral infarction, or carotid cavernous fistula). Moreover, concurrent presentation with posterior circulation cerebral infarction is even rarer, given different circulation territory from CCA. Here, we report on a patient with bilateral giant CCAs who presented with both typical and atypical symptoms. CASE PRESENTATION: An 88-year-old hypertensive woman presented with acute vertical oblique binocular diplopia, followed by complete ptosis of the right eye. Ophthalmic examination showed dysfunction of the right third, fourth, and sixth cranial nerves. Further examination revealed hypesthesia of the areas supplied by the ophthalmic (V1) and maxillary (V2) branches of the right trigeminal nerve. Bilateral giant cavernous carotid aneurysms, with a concurrent subacute right occipital lobe infarction, were discovered on brain imaging and angiogram. Additionally, a prominent right posterior communicating artery (PCOM) was revealed. Seven months later, clinical improvement with stable radiographic findings was documented without any intervention. CONCLUSIONS: Dysfunction of the third, fourth, and sixth cranial nerves, and the ophthalmic (V ) and maxillary (V ) branches of the trigeminal nerves, should necessitate brain imaging, with special attention given to the cavernous sinus. Despite unilateral symptomatic presentation, bilateral lesions cannot be excluded solely on the basis of clinical findings. CCA should be included in the differential diagnosis of cavernous sinus lesions. Although rare, ipsilateral posterior circulation cerebral infarction (i.e., occipital lobe infarction) can occur in CCA patients, presumably as a result of distal embolization through an ipsilateral, prominent PCOM. Spontaneous clinical improvement with stable radiographic support may occur.
[Mh] Termos MeSH primário: Infarto Encefálico/diagnóstico por imagem
Doenças das Artérias Carótidas/diagnóstico por imagem
Artéria Carótida Interna/diagnóstico por imagem
Trombose do Corpo Cavernoso/diagnóstico por imagem
Aneurisma Intracraniano/diagnóstico por imagem
Lobo Occipital/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Blefaroptose/diagnóstico
Artéria Carótida Interna/patologia
Diplopia/diagnóstico
Feminino
Seres Humanos
Angiografia por Ressonância Magnética
Imagem por Ressonância Magnética
Lobo Occipital/patologia
Campos Visuais
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0687-4


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[PMID]:28467342
[Au] Autor:Zarola F
[Ad] Endereço:Parkinson's Disease Clinical Center Azienda Sanitaria Locale RM H Via Gallerie di Sotto, snc Albano Laziale Roma. florazarola@libero.it.
[Ti] Título:Incidence of vascular brain damage in a population with Parkinson Disease: a clinical statistic study in comparison with a control group of patients afferent to neurological movement disorder outpatients clinic.
[So] Source:Acta Biomed;88(1):95-96, 2017 Apr 28.
[Is] ISSN:0392-4203
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:N/A.
[Mh] Termos MeSH primário: Infarto Encefálico/diagnóstico
Doença de Parkinson Secundária/complicações
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.23750/abm.v88i1.5008


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[PMID]:29213030
[Au] Autor:Alabri H; Lewis WD; Manjila S; Alkhachroum AM; De Georgia MA
[Ad] Endereço:Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.
[Ti] Título:Acute Bilateral Ophthalmoplegia Due to Vertebrobasilar Dolichoectasia: A Report of Two Cases.
[So] Source:Am J Case Rep;18:1302-1308, 2017 Dec 07.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Vertebrobasilar dolichoectasia (VBD) is a complex progressive arterial disease characterized by dilation, elongation, and tortuosity of the vertebral and basilar arteries, and may be congenital or acquired. VBD may lead to progressive compression of the brainstem, cranial nerve abnormalities, and intracranial hemorrhage, but may also be associated with arterial thrombosis, with ischemic stroke as the most common clinical outcome. CASE REPORT Two cases of VBD are presented, both with acute bilateral ophthalmoplegia and cranial nerve palsies, and vertebrobasilar arterial thrombosis that resulted in ischemic stroke. CONCLUSIONS VBD is a complex arterial disease with a variety of clinical manifestation, with bilateral ophthalmoplegia being a rare presentation. Clinical management of VBD is a challenge as there are no current management guidelines. Therefore, clinical management of cases of VBD should be individualized to balance the risks and benefits of treatment options for each patient.
[Mh] Termos MeSH primário: Infarto Encefálico/etiologia
Trombose Intracraniana/etiologia
Oftalmoplegia/etiologia
Insuficiência Vertebrobasilar/complicações
[Mh] Termos MeSH secundário: Doença Aguda
Idoso
Infarto Encefálico/diagnóstico por imagem
Doenças dos Nervos Cranianos/etiologia
Feminino
Seres Humanos
Trombose Intracraniana/diagnóstico por imagem
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:29283333
[Au] Autor:Andrabi SS; Parvez S; Tabassum H
[Ad] Endereço:Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India.
[Ti] Título:Neurosteroids and Ischemic Stroke: Progesterone a Promising Agent in Reducing the Brain Injury in Ischemic Stroke.
[So] Source:J Environ Pathol Toxicol Oncol;36(3):191-205, 2017.
[Is] ISSN:2162-6537
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Progesterone (P4), a well-known neurosteroid, is produced by ovaries and placenta in females and by adrenal glands in both sexes. Progesterone is also synthesized by central nervous system (CNS) tissues to perform various vital neurological functions in the brain. Apart from performing crucial reproductive functions, it also plays a pivotal role in neurogenesis, regeneration, cognition, mood, inflammation, and myelination in the CNS. A substantial body of experimental evidence from animal models documents the neuroprotective role of P4 in various CNS injury models, including ischemic stroke. Extensive data have revealed that P4 elicits neuroprotection through multiple mechanisms and systems in an integrated manner to prevent neuronal and glial damage, thus reducing mortality and morbidity. Progesterone has been described as safe for use at the clinical level through different routes in several studies. Data regarding the neuroprotective role of P4 in ischemic stroke are of great interest due to their potential clinical implications. In this review, we succinctly discuss the biosynthesis of P4 and distribution of P4 receptors (PRs) in the brain. We summarize our work on the general mechanisms of P4 mediated via the modulation of different PR and neurotransmitters. Finally, we describe the neuroprotective mechanisms of P4 in ischemic stroke models and related clinical prospects.
[Mh] Termos MeSH primário: Isquemia Encefálica/tratamento farmacológico
Fármacos Neuroprotetores/uso terapêutico
Neurotransmissores/uso terapêutico
Progesterona/uso terapêutico
Acidente Vascular Cerebral/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Infarto Encefálico/prevenção & controle
Seres Humanos
Progesterona/metabolismo
Progesterona/farmacologia
Receptores de Progesterona/fisiologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Neuroprotective Agents); 0 (Neurotransmitter Agents); 0 (Receptors, Progesterone); 4G7DS2Q64Y (Progesterone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1615/JEnvironPatholToxicolOncol.2017017156


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[PMID]:28681915
[Au] Autor:Lu H; Ma K; Jin L; Zhu H; Cao R
[Ad] Endereço:Intensive Care Unit of Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
[Ti] Título:17ß-estradiol rescues damages following traumatic brain injury from molecule to behavior in mice.
[So] Source:J Cell Physiol;233(2):1712-1722, 2018 Feb.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Traumatic brain injury (TBI) is a public health concern, and causes cognitive dysfunction, emotional disorders, and neurodegeration, as well. The currently available treatments are all symptom-oriented with unsatifying efficacy. It is highly demanded to understand its underlying mechanisms. Controlled cortical impact (CCI) was used to induce TBI in aged female mice subjected to ovariectomy. Brain damages were assessed with neurological severity score, brain infarction and edema. Morris water maze and elevated plus maze were applied to evaluate the levels of anxiety. Apoptosis in the hippocampus was assayed with Fluoro-Jade B staining and TUNEL staining. Western blot was employed to measure the expression of NMDA receptor subunits and phosphorylation of ERK1/2, and biochemical assays were used to estimate oxidative stress. 17beta-Estradiol (E2) was intraperitoneally administered at 10-80 µg/kg once per day for 7 consecutive days before or after CCI. Chronic administration of E2 both before and immediately after CCI conferred neuroprotection, reducing neurological severity score, brain infarction, and edema in TBI mice. Additionally, E2 improved many aspects of deleterious effects of TBI on the hippocampus, including neuronal apoptosis, dysfunction in spatial memory, reduction in NR2B, enhancement of oxidative stress, and activation of ERK1/2 pathway. The present study provides clue for the notion that E2 has therapeutic potential for both prevention and intervention of TBI-induced brain damages.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Edema Encefálico/tratamento farmacológico
Infarto Encefálico/tratamento farmacológico
Lesões Encefálicas Traumáticas/tratamento farmacológico
Estradiol/farmacologia
Hipocampo/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Edema Encefálico/metabolismo
Edema Encefálico/fisiopatologia
Edema Encefálico/psicologia
Infarto Encefálico/metabolismo
Infarto Encefálico/fisiopatologia
Infarto Encefálico/psicologia
Lesões Encefálicas Traumáticas/metabolismo
Lesões Encefálicas Traumáticas/fisiopatologia
Lesões Encefálicas Traumáticas/psicologia
Cognição/efeitos dos fármacos
Citoproteção
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Feminino
Hipocampo/metabolismo
Hipocampo/patologia
Hipocampo/fisiopatologia
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Camundongos Endogâmicos C57BL
Degeneração Neural
Ovariectomia
Estresse Oxidativo/efeitos dos fármacos
Fosforilação
Receptores de N-Metil-D-Aspartato/metabolismo
Índice de Gravidade de Doença
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NR2B NMDA receptor); 0 (Neuroprotective Agents); 0 (Receptors, N-Methyl-D-Aspartate); 4TI98Z838E (Estradiol); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.26083


  6 / 3925 MEDLINE  
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[PMID]:29068982
[Au] Autor:Jang SH; Lee HD
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
[Ti] Título:Delayed recovery of the affected finger extensors at chronic stage in a stroke patient: A case report.
[So] Source:Medicine (Baltimore);96(43):e8023, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A 33-year-old male presented with complete weakness of the right extremities due to corona radiata infarct. PATIENT CONCERNS: The main concerns of the patient is recovery of hand function especially related to finger extension. DIAGNOSES: Right corona radiata infarct. INTERVENTIONS: He underwent physical therapy and occupational therapy at the outpatient clinic of the rehabilitation department of the same university hospital until 2 years after onset. In addition, he underwent neuromuscular electrical stimulation for the right finger extensors continuously until 4 years after onset. OUTCOMES: At 6 months after onset, the weakness of his right side recovered to subnormal state except for the right finger extensors which were completely weak. At 1.5 years after onset, the right finger extensors began to show slow and continuous recovery. At 4 years after onset, the patient showed motor recovery in the right finger extensors to the extent that he was able to move against gravity. Discontinuation of the left corticospinal tract was observed on 2-month diffusion tensor tractography (DTT); however, the integrity of this discontinuation had recovered to the primary motor cortex on 4-year DTT. On 2-month transcranial magnetic stimulation (TMS), no motor-evoked potential was evoked; in contrast, motor-evoked potentials were obtained at the right-hand muscle on 4-year TMS study. LESSONS: We demonstrated unusual delayed and long-term recovery of the affected finger extensors in a patient with corona radiata infarct using DTT and TMS.
[Mh] Termos MeSH primário: Infarto Encefálico/fisiopatologia
Infarto Encefálico/reabilitação
Dedos/fisiopatologia
Reabilitação do Acidente Vascular Cerebral/métodos
[Mh] Termos MeSH secundário: Adulto
Infarto Encefálico/diagnóstico por imagem
Imagem de Tensor de Difusão
Terapia por Estimulação Elétrica
Dedos/diagnóstico por imagem
Seres Humanos
Masculino
Recuperação de Função Fisiológica/fisiologia
Fatores de Tempo
Estimulação Magnética Transcraniana
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008023


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[PMID]:28974628
[Au] Autor:Gory B; Piotin M; Haussen DC; Steglich-Arnholm H; Holtmannspötter M; Labreuche J; Taschner C; Eiden S; Nogueira RG; Papanagiotou P; Boutchakova M; Siddiqui A; Lapergue B; Dorn F; Cognard C; Killer-Oberpfalzer M; Mangiafico S; Ribo M; Behme D; Spiotta AM; Mazighi M; Turjman F; TITAN Investigators
[Ad] Endereço:From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; Univer
[Ti] Título:Thrombectomy in Acute Stroke With Tandem Occlusions From Dissection Versus Atherosclerotic Cause.
[So] Source:Stroke;48(11):3145-3148, 2017 Nov.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Tandem steno-occlusive lesions were poorly represented in randomized trials and represent a major challenge for endovascular thrombectomy in acute anterior circulation strokes. The impact of the cervical carotid lesion cause (ie, atherosclerotic versus dissection) on outcome of tandem patients endovascularly treated remains to be assessed. METHODS: We retrospectively analyzed individual data of prospectively collected consecutive tandem patients treated with endovascular thrombectomy. The primary outcome was favorable outcome at 90 days (modified Rankin Scale score of 0-2). Secondary efficacy outcomes included successful reperfusion (modified Thrombolysis in Cerebrovascular Infarction scores of 2b-3), time to reperfusion, and safety outcomes encompassed procedural complications, symptomatic intracerebral hemorrhage, and 90-day mortality. RESULTS: Among the 295 included patients, 65 had cervical carotid dissection and 230 had cervical carotid atherosclerotic cause. The rate of favorable outcome was 56.3% in the dissection group versus 47.6% in the atherosclerotic arm (center-, age-, and admission National Institutes of Health Stroke Scale-adjusted odds ratio, 1.08; 95% confidence interval, 0.50-2.30; =0.85). No significant differences were observed in secondary outcomes. The rates of successful reperfusion, symptomatic intracerebral hemorrhage, and 90-day mortality were 78.5% versus 74.5% ( =0.13), 4.6% versus 5.2% ( =1.0), and 7.8% versus 15.3% ( =0.94) in the dissection versus atherosclerotic groups, respectively. The median procedural time was 76 minutes (interquartile range, 52-95 minutes) in the dissection group and 67 minutes (interquartile range, 45-98 minutes) in the atherosclerotic group ( =0.24). CONCLUSIONS: We found no differences in the outcomes of patients with anterior circulation tandem atherosclerotic and dissection lesions treated with endovascular thrombectomy. Further studies are warranted.
[Mh] Termos MeSH primário: Infarto Encefálico
Dissecação da Artéria Carótida Interna
Hemorragia Cerebral
Procedimentos Endovasculares
Acidente Vascular Cerebral
Trombectomia
[Mh] Termos MeSH secundário: Doença Aguda
Idoso
Infarto Encefálico/fisiopatologia
Infarto Encefálico/cirurgia
Dissecação da Artéria Carótida Interna/fisiopatologia
Dissecação da Artéria Carótida Interna/cirurgia
Hemorragia Cerebral/fisiopatologia
Hemorragia Cerebral/cirurgia
Seres Humanos
Arteriosclerose Intracraniana/fisiopatologia
Arteriosclerose Intracraniana/cirurgia
Meia-Idade
Estudos Retrospectivos
Acidente Vascular Cerebral/fisiopatologia
Acidente Vascular Cerebral/cirurgia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.018264


  8 / 3925 MEDLINE  
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Wajngarten, Mauricio
Lotufo, Paulo A
Texto completo SciELO Brasil
[PMID]:28954006
[Au] Autor:Squarzoni P; Tamashiro-Duran JH; Duran FLS; Leite CC; Wajngarten M; Scazufca M; Menezes PR; Lotufo PA; Alves TCTF; Busatto GF
[Ad] Endereço:Departamento de Psiquiatria, Instituto de Psiquiatria (IPQ), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
[Ti] Título:High frequency of silent brain infarcts associated with cognitive deficits in an economically disadvantaged population.
[So] Source:Clinics (Sao Paulo);72(8):474-480, 2017 Aug.
[Is] ISSN:1980-5322
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE:: Using magnetic resonance imaging, we aimed to assess the presence of silent brain vascular lesions in a sample of apparently healthy elderly individuals who were recruited from an economically disadvantaged urban region (São Paulo, Brazil). We also wished to investigate whether the findings were associated with worse cognitive performance. METHODS:: A sample of 250 elderly subjects (66-75 years) without dementia or neuropsychiatric disorders were recruited from predefined census sectors of an economically disadvantaged area of Sao Paulo and received structural magnetic resonance imaging scans and cognitive testing. A high proportion of individuals had very low levels of education (4 years or less, n=185; 21 with no formal education). RESULTS:: The prevalence of at least one silent vascular-related cortical or subcortical lesion was 22.8% (95% confidence interval, 17.7-28.5), and the basal ganglia was the most frequently affected site (63.14% of cases). The subgroup with brain infarcts presented significantly lower levels of education than the subgroup with no brain lesions as well as significantly worse current performance in cognitive test domains, including memory and attention (p<0.002). CONCLUSIONS:: Silent brain infarcts were present at a substantially high frequency in our elderly sample from an economically disadvantaged urban region and were significantly more prevalent in subjects with lower levels of education. Covert cerebrovascular disease significantly contributes to cognitive deficits, and in the absence of magnetic resonance imaging data, this cognitive impairment may be considered simply related to ageing. Emphatic attention should be paid to potentially deleterious effects of vascular brain lesions in poorly educated elderly individuals from economically disadvantaged environments.
[Mh] Termos MeSH primário: Doenças Assintomáticas/epidemiologia
Infarto Encefálico/complicações
Infarto Encefálico/epidemiologia
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/etiologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Análise de Variância
Infarto Encefálico/fisiopatologia
Brasil/epidemiologia
Disfunção Cognitiva/fisiopatologia
Feminino
Seres Humanos
Testes de Inteligência
Imagem por Ressonância Magnética
Masculino
Testes Neuropsicológicos
Prevalência
Escalas de Graduação Psiquiátrica
Valores de Referência
Medição de Risco
Fatores de Risco
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28922851
[Au] Autor:Mehta RI; Tsymbalyuk N; Ivanova S; Stokum JA; Woo K; Gerzanich V; Simard JM
[Ad] Endereço:Department of Pathology and Laboratory Medicine; Center for Neurotherapeutics Discovery, Department of Neuroscience; Center for Translational Neuromedicine, University of Rochester, Rochester, New York; Department of Pathology; Department of Neurosurgery; Department of Physiology, University of Mary
[Ti] Título:α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke.
[So] Source:J Neuropathol Exp Neurol;76(10):898-907, 2017 10 01.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In nutrient restricted environments, the yeast endosulfines Igo1/2 are activated via TORC1 inhibition and function critically to initiate and coordinate the cellular stress response that promotes survival. We examined expression of αEnsa, the mammalian homolog of yeast endosulfines, in rat stroke. Prominent neuronal upregulation of αEnsa was identified in 3 patterns within the ischemic gradient: (1) neurons in GFAP-/HSF1+ cortex showed upregulation and near-complete nuclear translocation of αEnsa protein within hours of ischemic onset; (2) neurons in GFAP+/HSF1+ cortex showed upregulation in cytoplasm and nuclei that persisted for days; (3) neurons in GFAP+/HSF1- cortex showed delayed cytosolic-only upregulation that persisted for days. Findings were corroborated using in situ hybridization for ENSA mRNA. Rapamycin treatment was found to reduce infarct size and behavioral deficits and, in GFAP+/HSF1+ zones, enhance αEnsa neuronal nuclear translocation and mitigate cell death, relative to controls. Based on the conservation of TOR signaling across species, and on the finding that the Rim15-Igo1/2-PP2A module is triggered by substrate deprivation in eukaryotic yeast, we speculate that αEnsa is activated by substrate deprivation, functioning through the homologous MASTL-αEnsa/ARPP19-PP2A module to promote neuronal survival. In conjunction with recent studies suggesting a neuroprotective role, our data highlight a potential function for αEnsa within ischemic brain.
[Mh] Termos MeSH primário: Encéfalo/patologia
Regulação da Expressão Gênica/fisiologia
Neurônios/metabolismo
Peptídeos/metabolismo
Acidente Vascular Cerebral/patologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Infarto Encefálico/tratamento farmacológico
Infarto Encefálico/patologia
Moléculas de Adesão Celular/metabolismo
Chaperonina 60/metabolismo
Modelos Animais de Doenças
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Imunossupressores/farmacologia
Masculino
Proteínas Mitocondriais/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Neurônios/efeitos dos fármacos
Peptídeos/genética
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Ratos
Ratos Wistar
Sirolimo/farmacologia
Somatostatina/metabolismo
Acidente Vascular Cerebral/tratamento farmacológico
Acidente Vascular Cerebral/fisiopatologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Adhesion Molecules); 0 (Chaperonin 60); 0 (Esam protein, rat); 0 (Hspd1 protein, rat); 0 (Immunosuppressive Agents); 0 (Mitochondrial Proteins); 0 (Nerve Tissue Proteins); 0 (Peptides); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (endosulfine); 51110-01-1 (Somatostatin); W36ZG6FT64 (Sirolimus)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1093/jnen/nlx074


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[PMID]:28816948
[Au] Autor:Yanagiha K; Ishii K; Ueno T; Marushima A; Tamaoka A
[Ad] Endereço:aDepartment of Neurology bDepartment of Rehabilitation Medicine, University of Tsukuba Hospital cDepartment of Emergency and Critical Care Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
[Ti] Título:Medial medullary infarction caused by antineutrophil cytoplasmic antibody-related vasculitis: Case report and review of the literature.
[So] Source:Medicine (Baltimore);96(33):e7722, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Medial medullary infarction accounts for less than 1% of brain infarctions, and medial medullary infarctions is very rarely caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. PATIENT CONCERNS: We report the case of a 76-year-old man at low risk of arteriosclerosis who presented with disorders on the left side including gaze-evoked nystagmus, paralysis of the extremities, pyramidal signs, sensory disturbance, and dysesthesia. Brain magnetic resonance imaging also showed right medial medullary infarction. DIAGNOSES: Medial medullary infarction caused by ANCA-related vasculitis was diagnosed based on mild renal dysfunction and high levels of blood leukocytes, C-reactive protein (CRP), and myeloperoxidase (MPO)-ANCA. INTERVENTIONS AND OUTCOMES: He underwent two 3-day courses of steroid pulse therapy involving daily 1000 mg doses of methylpredonine. He then received 30 mg/day (0.5 mg/kg/day) of prednisolone (PSL) without other immunosuppressants. Levels of MPO-ANCA and the inflammatory marker CRP decreased rapidly a month after admission. Once MPO-ANCA became undetectable, the PSL dose was carefully reduced to 10 mg/day. To treat his paralysis, we provided rehabilitation with a Hybrid Assistive Limb five times starting at a month post-onset. His Barthel index score rose from 45 to 70 points. LESSONS: Medullary infarction is mostly caused by arteriosclerosis and vertebral arterial dissection. When systemic inflammatory findings are obtained, ANCA-associated vasculitis should be considered a potential cause, and steroid pulse therapy should be promptly administered.
[Mh] Termos MeSH primário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/complicações
Infarto Encefálico/diagnóstico
Infarto Encefálico/etiologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Idoso
Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/tratamento farmacológico
Infarto Encefálico/diagnóstico por imagem
Proteína C-Reativa/análise
Seres Humanos
Imunossupressores/uso terapêutico
Contagem de Leucócitos
Imagem por Ressonância Magnética
Masculino
Bulbo/patologia
Peroxidase/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Immunosuppressive Agents); 9007-41-4 (C-Reactive Protein); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007722



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