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  1 / 20442 MEDLINE  
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[PMID]:28455321
[Au] Autor:Derdeyn CP; Fiorella D; Lynn MJ; Turan TN; Cotsonis GA; Lane BF; Montgomery J; Janis LS; Chimowitz MI; SAMMPRIS Investigators
[Ad] Endereço:From the Departments of Radiology, Neurology, and Neurosurgery, University of Iowa Hospitals and Clinics (C.P.D.); Department of Neurosurgery, State University of New York, Stony Brook (D.F.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta,
[Ti] Título:Nonprocedural Symptomatic Infarction and In-Stent Restenosis After Intracranial Angioplasty and Stenting in the SAMMPRIS Trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis).
[So] Source:Stroke;48(6):1501-1506, 2017 06.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The purpose of this study was to investigate the frequency of symptomatic in-stent restenosis (ISR) and its contribution to nonprocedural symptomatic infarction in the SAMMPRIS trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis). METHODS: Patients without a periprocedural primary end point were followed up to determine the occurrence of any of the following events: ischemic stroke, cerebral infarct with temporary signs, or transient ischemic attack in the territory of the stented artery. Vascular imaging performed after these events was reviewed for ISR. Annual rates for symptomatic ISR were calculated using Kaplan-Meier estimates. RESULTS: Of 183 patients in the stenting group without a periprocedural primary end point, 27 (14.8%) had a symptomatic infarction (stroke or cerebral infarct with temporary signs) and 16 (8.7%) had transient ischemic attack alone in the territory during a median follow-up of 35.0 months. Of the 27 patients with infarctions, 17 (9.3%) had an ischemic stroke and 10 (5.5%) had a cerebral infarct with temporary signs alone. Adequate vascular imaging to evaluate ISR was available in 24 patients with infarctions (showing ISR in 16 [66.7%]) and in 10 patients with transient ischemic attack alone (showing ISR in 8 [80%]). The 1-, 2-, and 3-year rates (with 95% confidence limits) for symptomatic ISR in the SAMMPRIS stent cohort were 9.6% (6.1%-14.9%), 11.3% (7.5%-17.0%), and 14.0% (9.6%-20.2%), respectively. CONCLUSIONS: Symptomatic ISR occurred in at least 1 of 7 patients in SAMMPRIS by 3 years of follow-up and was likely responsible for the majority of nonprocedural cerebral infarctions. CLINICAL TRIAL REGISTRATION: URL: https://clinicaltrials.gov. Unique identifier: NCT00576693.
[Mh] Termos MeSH primário: Angioplastia com Balão/estatística & dados numéricos
Isquemia Encefálica/epidemiologia
Constrição Patológica/epidemiologia
Doenças Arteriais Intracranianas/epidemiologia
Doenças Arteriais Intracranianas/terapia
Complicações Pós-Operatórias/epidemiologia
Stents/estatística & dados numéricos
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Assistência ao Convalescente
Idoso
Angioplastia com Balão/efeitos adversos
Isquemia Encefálica/diagnóstico
Angiografia Cerebral
Infarto Cerebral/diagnóstico por imagem
Infarto Cerebral/epidemiologia
Constrição Patológica/diagnóstico por imagem
Feminino
Seres Humanos
Doenças Arteriais Intracranianas/diagnóstico por imagem
Ataque Isquêmico Transitório/diagnóstico por imagem
Ataque Isquêmico Transitório/epidemiologia
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Complicações Pós-Operatórias/diagnóstico por imagem
Recidiva
Risco
Stents/efeitos adversos
Acidente Vascular Cerebral/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.116.014537


  2 / 20442 MEDLINE  
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[PMID]:29465539
[Au] Autor:Wang V; Hsieh CC; Huang YL; Chen CP; Hsieh YT; Chao TH
[Ad] Endereço:Department of Neurology, Cardinal Tien Hospital.
[Ti] Título:Different utilization of intensive care services (ICSs) for patients dying of hemorrhagic and ischemic stroke, a hospital-based survey.
[So] Source:Medicine (Baltimore);97(8):e0017, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The intensive care service (ICS) saves lives and rescues the neurological function of stroke patients. We wondered the different utilization of ICS for patients with ischemic and hemorrhagic stroke, especially those who died within 30 days after stroke.Sixty-seven patients died during 2011 to 2015 due to acute stroke (42 due to intracranial hemorrhage [ICH]; 25 due to cerebral infarct [CI]). The durations of hospital stay (hospital staying days [HSDs]) and ICS staying days (ISDs) and codes of the do-not-resuscitate (DNR) were surveyed among these medical records. Statistics included chi-square and descriptive analyses.In this study, CI patients had a longer HSD (mean 14.3 days), as compared with ICH patients (mean 8.3 days); however, the ICH patients had a higher percentage of early entry within the first 24 hours of admission into ICS than CI group (95.1% vs 60.0%, P = .003). A higher rate of CI patients died in holidays or weekends than those with ICH (44.0% vs 21.4%, P = .051). DNR, requested mainly from direct descendants (children or grandchildren), was coded in all 25 CI patients (100.0%) and 38 ICH patients (90.5%). More cases with early DNR coded within 24 hours after admission occurred in ICH group (47%, 12% in CI patients, P = .003). None of the stroke patient had living wills. Withhold of endotracheal intubation (ETI) occurred among CI patients, more than for ICH patients (76.0% vs 18.4%, P < .005).In conclusion, CI patients longer HSD, ISD, higher mortality within holidays or weekends, and higher ETI withhold; but less percentage of ICS utilization expressed by a lower ISD/HSD ratio. This ICS utilization is a key issue of medical quality for stroke care.
[Mh] Termos MeSH primário: Infarto Cerebral/terapia
Cuidados Críticos/utilização
Hospitais/estatística & dados numéricos
Hemorragias Intracranianas/terapia
Acidente Vascular Cerebral/terapia
[Mh] Termos MeSH secundário: Idoso
Causas de Morte
Infarto Cerebral/mortalidade
Feminino
Hospitalização/estatística & dados numéricos
Seres Humanos
Hemorragias Intracranianas/mortalidade
Masculino
Sistema de Registros
Acidente Vascular Cerebral/mortalidade
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010017


  3 / 20442 MEDLINE  
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[PMID]:28834316
[Au] Autor:Ogunsile FJ; Currie KL; Rodeghier M; Kassim A; DeBaun MR; Sharma D
[Ad] Endereço:Division of Hematology/Oncology, Department of Medicine, Johns Hopkins University Medical Center, Baltimore, Maryland.
[Ti] Título:History of parvovirus B19 infection is associated with silent cerebral infarcts.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The relationship between silent cerebral infarcts (SCIs) and history of parvovirus B19 (B19V) has not been systematically evaluated. As an ancillary study from the Silent Cerebral Infarct Trial (SIT) (NCT00072761), we tested the hypothesis that a history of B19V infection is associated with an increased prevalence of SCIs in children with sickle cell anemia. PROCEDURE: We used a retrospective cross-sectional cohort study design; each participant underwent a brain magnetic resonance imaging (MRI) scan and medical record review for prior B19V infection (n = 958). RESULTS: SCI was present in 30% (287 of 958) of participants and 17% (165 of 958) had a history of B19V infection. Based on prior evidence that low baseline hemoglobin (Hgb) levels are associated with increased odds of SCI, Hgb levels were divided into tertiles (<7.6 g/dl, ≥7.6-≤8.5 g/dl, ≥8.6 g/dl) and multivariable analysis was used to determine the relationship between the joint effect of prior B19V infection, Hgb levels, and SCI. Prior B19V infection and the lowest Hgb tertile were associated with increased risk of SCI (odds ratio [OR] 2.12; 95% CI, 1.17-3.84; P = 0.013); no prior B19V infection and the highest Hgb tertile were associated with a decreased risk (OR 0.56; 95% CI, 0.38-0.84; P = 0.004). CONCLUSIONS: Efforts to decrease the incidence of B19V infection, such as the development of a B19V vaccine, may decrease SCI prevalence.
[Mh] Termos MeSH primário: Infarto Cerebral
Eritema Infeccioso
Imagem por Ressonância Magnética
Parvovirus B19 Humano
[Mh] Termos MeSH secundário: Infarto Cerebral/diagnóstico por imagem
Infarto Cerebral/epidemiologia
Infarto Cerebral/etiologia
Infarto Cerebral/virologia
Criança
Pré-Escolar
Eritema Infeccioso/complicações
Eritema Infeccioso/diagnóstico por imagem
Eritema Infeccioso/epidemiologia
Feminino
Seres Humanos
Incidência
Masculino
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26767


  4 / 20442 MEDLINE  
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[PMID]:29269690
[Au] Autor:Kikuno M; Koga M; Kume Y; Ohtsuka T; Hayakawa M; Toyoda K
[Ad] Endereço:Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center.
[Ti] Título:[A case of cardiogenic embolism, which occurred under appropriate warfarin use, treated with thoracoscopic left atrial appendectomy].
[So] Source:Rinsho Shinkeigaku;58(1):9-14, 2018 Jan 26.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 74-year-old man with a past medical history of bradycardiac atrial fibrillation and an old cerebral infarction presented with dysarthria. He had been treated with warfarin and PT-INR on admission was 2.0. MRI of the head revealed an acute ischemic stroke involving the cerebellum and left occipital lobe. Because transesophageal cardiac echography showed a thrombus in the left atrial appendage, anticoagulant treatment with warfarin and heparin was initiated. The thrombus was enlarging; therefore, we changed the anticoagulant therapy to apixaban with heparin on day 11. On day 17, a hemorrhagic cerebral infarction occurred. After the hemorrhage diminished, we treated him with warfarin aiming for a PT-INR between 3 and 4. The thrombus gradually shrank and disappeared on day 110. Finally, a thoracoscopic left atrial appendectomy was performed as a secondary prevention, with no recurrence till date.
[Mh] Termos MeSH primário: Anticoagulantes/administração & dosagem
Procedimentos Cirúrgicos Cardíacos/métodos
Infarto Cerebral/etiologia
Átrios do Coração/cirurgia
Cardiopatias/etiologia
Toracoscopia/métodos
Trombose/etiologia
Varfarina/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Quimioterapia Combinada
Cardiopatias/terapia
Heparina/administração & dosagem
Seres Humanos
Coeficiente Internacional Normatizado
Masculino
Pirazóis/administração & dosagem
Piridonas/administração & dosagem
Recidiva
Síndrome do Nó Sinusal/complicações
Trombose/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants); 0 (Pyrazoles); 0 (Pyridones); 3Z9Y7UWC1J (apixaban); 5Q7ZVV76EI (Warfarin); 9005-49-6 (Heparin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001065


  5 / 20442 MEDLINE  
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[PMID]:28469098
[Au] Autor:Fang XJ; Yu M; Wu Y; Zhang ZH; Wang WW; Wang ZX; Yuan Y
[Ad] Endereço:Department of Neurology, Peking University First Hospital, Beijing 100034, China.
[Ti] Título:Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
[So] Source:Chin Med J (Engl);130(9):1042-1048, 2017 May 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation. We performed enhanced depth imaging optical coherence tomography (EDI-OCT) to evaluate the retinal vessel changes in CADASIL patients and assessed their consonance with brain magnetic resonance imaging (MRI) findings. METHODS: Of 27 genetically confirmed patients and an equal number of controls were recruited at the Peking University First Hospital from January 2015 to August 2016. All patients underwent 7T-MRI of the brain. Fazekas score, number of small infarcts and microbleeds were evaluated. All patients and controls underwent EDI-OCT to measure subfoveal choroidal thickness (SFCT), inner and outer diameters as well as arterial and venous wall thickness, and arterial venous ratio of the inner (AVRin) and outer diameters (AVRout). The relation between retinal vessel changes and Fazekas scores, numbers of small infarcts, or microbleeds was analyzed. Paired t-test was used to compare the SFCT and retinal vessel measurement data between patients and controls. Spearman's correlation was used to investigate the correlation between retinal vessel changes and MRI lesions. RESULTS: In CADASIL patients, mean SFCT (268.37 ± 46.50 µm) and mean arterial inner diameter (93.46 ± 9.70 µm) were significantly lower than that in controls (P < 0.001,P = 0.048, respectively). Mean arterial outer diameter (131.74 ± 10.87 µm), venous inner (128.99 ± 13.62 µm) and outer diameter (164.82 ± 14.77 µm), and mean arterial (19.13 ± 1.85 µm) and venous (17.91 ± 2.76 µm) wall thickness were significantly higher than that in controls (P = 0.023,P = 0.004,P < 0.001,P < 0.001, respectively). Arterial inner diameter (rs= -0.39, P= 0.044), AVRin (rs= -0.65,P < 0.001), and AVRout (rs= -0.56, P= 0.002) showed a negative correlation with the number of small infarcts. Venous inner diameter (rs = 0.46, P= 0.016) showed a positive correlation with the number of small infarcts. Venous inner diameter (rs = 0.59, P= 0.002), outer diameter (rs = 0.47, P= 0.017), showed a positive correlation with the number of cerebral microbleeds (CMBs). AVRin (rs= -0.52, P= 0.007) and AVRout (rs= -0.40, P= 0.048) showed a negative correlation with the number of CMBs. CONCLUSIONS: Measurement of retinal vessels using EDI-OCT correlates moderately well with MRI parameters. EDI-OCT might be a useful evaluation tool for CADASIL patients.
[Mh] Termos MeSH primário: Leucoencefalopatias/patologia
Imagem por Ressonância Magnética/métodos
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Adulto
Encéfalo/metabolismo
CADASIL
Infarto Cerebral/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Mutação
Receptor Notch3/genética
Vasos Retinianos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Notch3)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.204935


  6 / 20442 MEDLINE  
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[PMID]:29443779
[Au] Autor:Zhang J; Xu R; Li Z; Zha W
[Ad] Endereço:Department of Orthopaedics, Mingzhou Hospital of Zhejiang University, Ningbo, Zhejiang Province, China.
[Ti] Título:Cerebral infarction due to malposition of cervical pedicle screw: A case report.
[So] Source:Medicine (Baltimore);97(7):e9937, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Malposition of cervical pedicle screw (CPS) has a risk of vertebral artery (VA) injury which sometimes may cause unexpected and catastrophic outcome. A rare case of delayed onset of cerebral infarction caused by malposition of CPS was reported. PATIENT CONCERNS: A 23-year-old man who underwent a posterior cervical reduction and fusion of C4-5 using CPS fixation and allograft for cervical spine injury is presented. The patient suffered progressively weakness and numbness for both of upper and lower extremities 1 day after the operation. Computed tomography scans revealed bilateral occupation of the pedicle screws in the foramen of C4 and C5 and the magnetic resonance imaging (MRI) displayed several areas of infarction in the brainstem and cerebellum. DIAGNOSES: Plain radiographs of the cervical spine revealed the C4 vertebral body and MRI displayed a disruption of the anterior longitudinal ligament on the level of C4-5 and severe injury to the soft tissues of the cervical spine at admission. Brainstem and cerebellum infarction was diagnosed at postoperative. INTERVENTION: A revision surgery was decided to remove all of the pedicle screws and place lateral mass screws instead. OUTCOMES: The patient felt better on his all of 4 extremities following revision surgery. Fortunately, he was neurologically close to normal at a 3-month follow-up. LESSONS: Delayed onset of cerebral infarction is rarely reported complication caused by malposition of CPS. When a CPS perforates the transverse foramen and causes symptom of cerebral infarction, a revision surgery in time is strongly recommended to prevent further sequelae.
[Mh] Termos MeSH primário: Infarto Cerebral/etiologia
Vértebras Cervicais/lesões
Vértebras Cervicais/cirurgia
Parafusos Pediculares/efeitos adversos
Complicações Pós-Operatórias/etiologia
Fusão Vertebral/efeitos adversos
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Adulto
Infarto Cerebral/cirurgia
Seres Humanos
Masculino
Complicações Pós-Operatórias/cirurgia
Reoperação
Estudos Retrospectivos
Fusão Vertebral/instrumentação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009937


  7 / 20442 MEDLINE  
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[PMID]:29390539
[Au] Autor:Xu F; Liu C; Huang X
[Ad] Endereço:Department of Traditional Chinese Medicine, Xuanwu Hospital Capital Medical University, Beijing, China.
[Ti] Título:Oral contraceptives caused venous sinus thrombosis complicated with cerebral artery infarction and secondary epileptic seizures: A case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9383, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Venous sinus thrombosis is a special type of cerebrovascular disease. Its incidence is low and its symptoms are lack of specificity. And its early diagnosis and treatment are very difficult. PATIENT CONCERNS: This paper reported a rare case of a 43-year-old female who presented with cerebral venous thrombosis (CVT) complicated with cerebral artery infarction and secondary epileptic seizures due to oral contraceptives. DIAGNOSES: The final diagnosis was intracranial venous sinus thrombosis, acute cerebral infarction in the left parietal lobe, intracranial hypertension syndrome, and continuous epilepsy. INTERVENTIONS: The patient recovered well after active treatment. OUTCOMES: Three months after discharge, the muscle strength of the right limb of the patient was significantly increased, and no recurrence of neurological symptoms occurred. LESSONS: In conclusion, early diagnosis, correct evaluation, and standard treatment are still important challenges for CVT. Active treatment is recommended.
[Mh] Termos MeSH primário: Infarto Cerebral/etiologia
Anticoncepcionais Orais Sintéticos/efeitos adversos
Desogestrel/efeitos adversos
Epilepsia/etiologia
Trombose dos Seios Intracranianos/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Infarto Cerebral/diagnóstico
Epilepsia/diagnóstico
Feminino
Seres Humanos
Trombose dos Seios Intracranianos/complicações
Trombose dos Seios Intracranianos/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contraceptives, Oral, Synthetic); 81K9V7M3A3 (Desogestrel)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009383


  8 / 20442 MEDLINE  
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[PMID]:29288767
[Au] Autor:Ward SJ; Castelli F; Reichenbach ZW; Tuma RF
[Ad] Endereço:Lewis Katz School of Medicine at Temple University, United States. Electronic address: saraward@temple.edu.
[Ti] Título:Surprising outcomes in cannabinoid CB1/CB2 receptor double knockout mice in two models of ischemia.
[So] Source:Life Sci;195:1-5, 2018 Feb 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: We tested the hypothesis that CB1/CB2 receptor double knockout would produce significant increases in infarct size and volume and significant worsening in clinical score, using two mouse models, one of permanent ischemia and one of ischemia/reperfusion. MAIN METHODS: Focal cerebral infarcts were created using either photo induced permanent injury or transient middle cerebral artery occlusion. Infarct volume and motor function were evaluated in cannabinoid receptor 1/cannabinoid receptor 2 double knockout mice. KEY FINDINGS: The results surprisingly revealed that CB1/CB2 double knockout mice showed improved outcomes, with the most improvements in the mouse model of permanent ischemia. SIGNIFICANCE: Although the number of individuals suffering from stroke in the United States and worldwide will continue to grow, therapeutic intervention for treatment following stroke remains frustratingly limited. Both the cannabinoid 1 receptor (CB1R) and the cannabinoid 2 receptor (CB2R) have been studied in relationship to stroke. Deletion of the CB2R has been shown to worsen outcome, while selective CB2R agonists have been demonstrated to be neuroprotective following stroke. Although initial studies of CB1R knockout mice demonstrated increased injury following stroke, indicating that activation of the CB1R was neuroprotective, later studies of selective antagonists of the CB1R also demonstrated a protective effect. Surprisingly the double knockout animals had improved outcome. Since the phenotype of the double knockout is not dramatically changed, significant changes in the contribution of other homeostatic pathways in compensation for the loss of these two important receptors may explain these apparently contradictory results.
[Mh] Termos MeSH primário: Isquemia Encefálica/genética
Isquemia Encefálica/fisiopatologia
Receptor CB1 de Canabinoide/genética
Receptor CB2 de Canabinoide/genética
[Mh] Termos MeSH secundário: Animais
Encéfalo/patologia
Isquemia Encefálica/terapia
Infarto Cerebral/etiologia
Infarto Cerebral/genética
Infarto Cerebral/patologia
Circulação Cerebrovascular/genética
Infarto da Artéria Cerebral Média
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fármacos Neuroprotetores/uso terapêutico
Receptor CB1 de Canabinoide/antagonistas & inibidores
Receptor CB2 de Canabinoide/antagonistas & inibidores
Acidente Vascular Cerebral/genética
Acidente Vascular Cerebral/fisiopatologia
Acidente Vascular Cerebral/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CNR1 protein, mouse); 0 (Cnr2 protein, mouse); 0 (Neuroprotective Agents); 0 (Receptor, Cannabinoid, CB1); 0 (Receptor, Cannabinoid, CB2)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  9 / 20442 MEDLINE  
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[PMID]:29369194
[Au] Autor:Zhang L; Nan G; Mao Y; Chi L
[Ad] Endereço:Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.
[Ti] Título:Rapid improvement of angiostenosis due to isolated middle cerebral artery dissection: A case report.
[So] Source:Medicine (Baltimore);97(4):e9695, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Intracranial arterial dissection is a rare cause of ischemic stroke, and isolated middle cerebral artery dissection (MCAD) is extremely rare, having been described only in sparse case reports. The etiology, clinicoradiological features, and treatment strategies are not yet well understood. PATIENT CONCERNS: A 49-year-old man presented with rapidly progressive aphasia and motor disturbance of the right limbs. DIAGNOSES: Neuroimaging evaluation confirmed a diagnosis of MCAD and cerebral infarction. INTERVENTIONS: The patient underwent oral anti-platelet therapy (100 mg aspirin daily). OUTCOMES: The patient recovered to normal status within 2 weeks following antiplatelet treatment. During a follow-up period of 2 years, he remained neurologically asymptomatic and led a virtually normal life. LESSONS: It is crucial for clinicians to be aware of this entity, as the diagnosis of MCAD is quite challenging. Antiplatelet therapy is effective for treating this condition, and the prognosis can be favorable.
[Mh] Termos MeSH primário: Aneurisma Dissecante
Afasia/etiologia
Infarto Cerebral/etiologia
Aneurisma Intracraniano
Artéria Cerebral Média
[Mh] Termos MeSH secundário: Aneurisma Dissecante/complicações
Aneurisma Dissecante/diagnóstico por imagem
Aneurisma Dissecante/tratamento farmacológico
Revascularização Cerebral/métodos
Constrição Patológica
Seres Humanos
Aneurisma Intracraniano/complicações
Aneurisma Intracraniano/diagnóstico por imagem
Aneurisma Intracraniano/tratamento farmacológico
Masculino
Meia-Idade
Artéria Cerebral Média/diagnóstico por imagem
Inibidores da Agregação de Plaquetas/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Platelet Aggregation Inhibitors)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009695


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[PMID]:29332915
[Au] Autor:Aizawa Y; Nakai T; Saito Y; Monno K; Morikawa T; Kogawa R; Hatta T; Tamaki T; Kato M; Arimoto M; Osaka S; Sunagawa K; Tang XY; Tanaka M; Hao H; Hirayama A
[Ad] Endereço:Division of Cardiology, Department of Medicine, Nihon University School of Medicine.
[Ti] Título:Calcified Amorphous Tumor-Induced Acute Cerebral Infarction.
[So] Source:Int Heart J;59(1):240-242, 2018 Jan 27.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We report the case of a 38-year-old woman who was admitted for acute cerebral infarction linked to a cardiac calcified amorphous tumor (CAT) and related mitral annular calcification (MAC). The cardiac mass was removed, and mitral valve replacement surgery was performed. Pathological examination revealed an amorphous accumulation of degenerating material within both lesions, indicating that build-up of calcium along the mitral annulus and subsequent rupture of the fibrotic tissue may be involved in the initiation and progression of CAT.
[Mh] Termos MeSH primário: Calcinose/complicações
Procedimentos Cirúrgicos Cardíacos/métodos
Infarto Cerebral/etiologia
Neoplasias Cardíacas/complicações
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Calcinose/diagnóstico
Calcinose/cirurgia
Infarto Cerebral/diagnóstico
Diagnóstico Diferencial
Ecocardiografia Transesofagiana
Feminino
Neoplasias Cardíacas/diagnóstico
Neoplasias Cardíacas/cirurgia
Seres Humanos
Valva Mitral/patologia
Valva Mitral/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180116
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.17-020



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