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[PMID]:28449099
[Au] Autor:Allagnat F; Dubuis C; Lambelet M; Le Gal L; Alonso F; Corpataux JM; Déglise S; Haefliger JA
[Ad] Endereço:Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
[Ti] Título:Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation.
[So] Source:Cardiovasc Res;113(7):805-816, 2017 Jun 01.
[Is] ISSN:1755-3245
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aims: Intimal hyperplasia (IH) is an abnormal response to vessel injury characterized by the dedifferentiation, migration, and proliferation of quiescent vascular smooth muscle cells (VSMC) to form a neointima layer. Vascular connexins (Cx) are involved in the pathophysiology of various vascular diseases, and Cx43, the main Cx expressed in VSMC, has been shown to promote VSMC proliferation and IH. The aim of this study was to investigate the participation of another Cx, namely Cx37, in the formation of the neointima layer. Methods and results: Wild-type (WT) and Cx37-deficient (Cx37-/-) C57BL/6J mice were subjected to carotid artery ligation (CAL), a model of vessel injury and IH. The neointima developed linearly in WT until 28 days post surgery. In contrast, the neointima layer was almost absent 14 days after surgery in Cx37-/- mice, and twice as more developed after 28 days compared to WT mice. This large neointima formation correlated with a two-fold increase in cell proliferation in the media and neointima regions between 14 and 28 days in Cx37-/- mice compared to WT mice. The CAL triggered Cx43 overexpression in the media and neointima layers of ligated carotids in WT mice, and selectively up-regulated Cx37 expression in the media layer, but not in the neointima layer. The de novo expression of Cx37 in human primary VSMC reduced cell proliferation and P-Akt levels, in association with lower Cx43 levels, whereas Cx43 overexpression increased P-Akt levels. Conclusion: The presence of Cx37 in the media layer of injured arteries restrains VSMC proliferation and limits the development of IH, presumably by interfering with the pro-proliferative effect of Cx43 and the Akt pathway.
[Mh] Termos MeSH primário: Lesões das Artérias Carótidas/metabolismo
Estenose das Carótidas/metabolismo
Proliferação Celular
Conexinas/metabolismo
Músculo Liso Vascular/metabolismo
Miócitos de Músculo Liso/metabolismo
Neointima
[Mh] Termos MeSH secundário: Idoso
Animais
Artérias Carótidas/metabolismo
Artérias Carótidas/patologia
Artérias Carótidas/cirurgia
Lesões das Artérias Carótidas/genética
Lesões das Artérias Carótidas/patologia
Estenose das Carótidas/genética
Estenose das Carótidas/patologia
Células Cultivadas
Conexina 43/metabolismo
Conexinas/deficiência
Conexinas/genética
Modelos Animais de Doenças
Feminino
Seres Humanos
Hiperplasia
Ligadura
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Músculo Liso Vascular/patologia
Miócitos de Músculo Liso/patologia
Fosforilação
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Connexin 43); 0 (Connexins); 0 (connexin 37); 0 (connexin 43 protein, rat); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1093/cvr/cvx079


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[PMID]:28455318
[Au] Autor:Rantner B; Kollerits B; Roubin GS; Ringleb PA; Jansen O; Howard G; Hendrikse J; Halliday A; Gregson J; Eckstein HH; Calvet D; Bulbulia R; Bonati LH; Becquemin JP; Algra A; Brown MM; Mas JL; Brott TG; Fraedrich G; Carotid Stenosis Trialists' Collaboration
[Ad] Endereço:From the Department of Vascular Surgery (B.R., G.F.) and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology (B.K.), Medical University of Innsbruck, Austria; Cardiovascular Associates of the Southeast, Birmingham, AL (G.S.R.); Department of Neurolog
[Ti] Título:Early Endarterectomy Carries a Lower Procedural Risk Than Early Stenting in Patients With Symptomatic Stenosis of the Internal Carotid Artery: Results From 4 Randomized Controlled Trials.
[So] Source:Stroke;48(6):1580-1587, 2017 06.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Patients undergoing carotid endarterectomy (CEA) for symptomatic stenosis of the internal carotid artery benefit from early intervention. Heterogeneous data are available on the influence of timing of carotid artery stenting (CAS) on procedural risk. METHODS: We investigated the association between timing of treatment (0-7 days and >7 days after the qualifying neurological event) and the 30-day risk of stroke or death after CAS or CEA in a pooled analysis of individual patient data from 4 randomized trials by the Carotid Stenosis Trialists' Collaboration. Analyses were done per protocol. To obtain combined estimates, logistic mixed models were applied. RESULTS: Among a total of 4138 patients, a minority received their allocated treatment within 7 days after symptom onset (14% CAS versus 11% CEA). Among patients treated within 1 week of symptoms, those treated by CAS had a higher risk of stroke or death compared with those treated with CEA: 8.3% versus 1.3%, risk ratio, 6.7; 95% confidence interval, 2.1 to 21.9 (adjusted for age at treatment, sex, and type of qualifying event). For interventions after 1 week, CAS was also more hazardous than CEA: 7.1% versus 3.6%, adjusted risk ratio, 2.0; 95% confidence interval, 1.5 to 2.7 ( value for interaction with time interval 0.06). CONCLUSIONS: In randomized trials comparing stenting with CEA for symptomatic carotid artery stenosis, CAS was associated with a substantially higher periprocedural risk during the first 7 days after the onset of symptoms. Early surgery is safer than stenting for preventing future stroke. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00190398; URL: http://www.controlled-trials.com. Unique identifier: ISRCTN57874028; Unique identifier: ISRCTN25337470; URL: http://www.clinicaltrials.gov. Unique identifier: NCT00004732.
[Mh] Termos MeSH primário: Artéria Carótida Interna/cirurgia
Estenose das Carótidas/cirurgia
Endarterectomia das Carótidas/efeitos adversos
Procedimentos Endovasculares/efeitos adversos
Avaliação de Processos e Resultados (Cuidados de Saúde)/estatística & dados numéricos
Stents/efeitos adversos
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Idoso
Estenose das Carótidas/epidemiologia
Endarterectomia das Carótidas/estatística & dados numéricos
Procedimentos Endovasculares/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Meia-Idade
Stents/estatística & dados numéricos
Acidente Vascular Cerebral/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.116.016233


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[PMID]:29324900
[Au] Autor:Roberts JM; Maniskas ME; Fraser JF; Bix GJ
[Ad] Endereço:Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America.
[Ti] Título:Internal carotid artery stenosis: A novel surgical model for moyamoya syndrome.
[So] Source:PLoS One;13(1):e0191312, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Moyamoya is a cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries. There are two forms: Disease and Syndrome, with each characterized by the sub-population it affects. Moyamoya syndrome (MMS) is more prominent in adults in their 20's-40's, and is often associated with autoimmune diseases. Currently, there are no surgical models for inducing moyamoya syndrome, so our aim was to develop a new animal model to study this relatively unknown cerebrovascular disease. Here, we demonstrate a new surgical technique termed internal carotid artery stenosis (ICAS), to mimic MMS using micro-coils on the proximal ICA. We tested for Moyamoya-like vasculopathies by fluorescently labelling the mouse cerebrovasculature with Di I for visualization and analysis of vessel diameter at the distal ICA and anastomoses on the cortical surface. Results show a significant narrowing of the distal ICA and anterior cerebral artery (ACA) in the Circle of Willis, as observed in humans. There is also a significant decrease in the number of anastomoses between the middle cerebral artery (MCA) and the ACA in the watershed region of the cortex. While further characterization is needed, this ICAS model can be applied to transgenic mice displaying co-morbidities as observed within the Moyamoya syndrome population, allowing a better understanding of the disease and development of novel treatments.
[Mh] Termos MeSH primário: Artéria Carótida Interna/cirurgia
Estenose das Carótidas/cirurgia
Doença de Moyamoya/cirurgia
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Modelos Animais de Doenças
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191312


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[PMID]:27771154
[Au] Autor:Barbieri M; Marfella R; Esposito A; Rizzo MR; Angellotti E; Mauro C; Siniscalchi M; Chirico F; Caiazzo P; Furbatto F; Bellis A; D'Onofrio N; Vitiello M; Ferraraccio F; Paolisso G; Balestrieri ML
[Ad] Endereço:Department of Medical, Surgical, Neurological, Aging and Metabolic Sciences, Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy. Electronic address: michelangela.barbieri@unina2.it.
[Ti] Título:Incretin treatment and atherosclerotic plaque stability: Role of adiponectin/APPL1 signaling pathway.
[So] Source:J Diabetes Complications;31(2):295-303, 2017 Feb.
[Is] ISSN:1873-460X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: Glucagon like peptide 1 (GLP-1) analogues and dipeptidyl peptidase IV (DPP-4) inhibitors reduce atherosclerosis progression in type 2 diabetes mellitus (T2DM) patients and are associated with morphological and compositional characteristics of stable plaque phenotype. GLP-1 promotes the secretion of adiponectin which exerts anti-inflammatory effects through the adaptor protein PH domain and leucine zipper containing 1 (APPL1). The potential role of APPL1 expression in the evolution of atherosclerotic plaque in TDM2 patients has not previously evaluated. METHODS: The effect of incretin therapy in the regulation of adiponectin/APPL1 signaling was evaluated both on carotid plaques of asymptomatic diabetic (n=71) and non-diabetic patients (n=52), and through in vitro experiments on endothelial cell (EC). RESULTS: Atherosclerotic plaques of T2DM patients showed lower adiponectin and APPL1 levels compared with non-diabetic patients, along with higher oxidative stress, tumor necrosis factor-α (TNF-α), vimentin, and matrix metalloproteinase-9 (MMP-9) levels. Among T2DM subjects, current incretin-users presented higher APPL1 and adiponectin content compared with never incretin-users. Similarly, in vitro observations on endothelial cells co-treated with high-glucose (25mM) and GLP-1 (100nM) showed a greater APPL1 protein expression compared with high-glucose treatment alone. CONCLUSIONS: Our findings suggest a potential role of adiponectin/APPL1 signaling in mediating the effect of incretin in the prevention of atherosclerosis progression or plaque vulnerability in T2DM.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transdução de Sinal/agonistas
Adiponectina/metabolismo
Diabetes Mellitus Tipo 2/tratamento farmacológico
Angiopatias Diabéticas/prevenção & controle
Incretinas/uso terapêutico
Placa Aterosclerótica/prevenção & controle
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Idoso
Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/uso terapêutico
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Estenose das Carótidas/complicações
Estenose das Carótidas/epidemiologia
Estenose das Carótidas/prevenção & controle
Estenose das Carótidas/cirurgia
Células Cultivadas
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/patologia
Angiopatias Diabéticas/epidemiologia
Angiopatias Diabéticas/patologia
Angiopatias Diabéticas/cirurgia
Endarterectomia das Carótidas
Endotélio Vascular/efeitos dos fármacos
Endotélio Vascular/imunologia
Endotélio Vascular/metabolismo
Endotélio Vascular/patologia
Feminino
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Incretinas/farmacologia
Itália/epidemiologia
Masculino
Estresse Oxidativo/efeitos dos fármacos
Placa Aterosclerótica/complicações
Placa Aterosclerótica/epidemiologia
Placa Aterosclerótica/patologia
Fatores de Risco
Prevenção Secundária
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (APPL1 protein, human); 0 (Adaptor Proteins, Signal Transducing); 0 (Adiponectin); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Incretins); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28454636
[Au] Autor:Udesh R; Mehta A; Gleason T; Thirumala PD
[Ad] Endereço:Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
[Ti] Título:Carotid artery disease and perioperative stroke risk after surgical aortic valve replacement: A nationwide inpatient sample analysis.
[So] Source:J Clin Neurosci;42:91-96, 2017 Aug.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:To study the role of carotid stenosis (CS) and cerebrovascular disease as independent risk factors for perioperative stroke following surgical aortic valve replacement (SAVR). The National Inpatient Sample (NIS) database was used for our study. All patients who underwent SAVR from 1999 to 2011 were identified using ICD-9 codes. Univariate and multivariate analysis of baseline characteristics, Elixhauser comorbidities and other covariates were examined to identify independent predictors of perioperative strokes following SAVR. Data on 50,979 patients who underwent SAVR from 1999 to 2011 was obtained. The mean age of the study cohort was 60.5. The study patients were predominantly Caucasian (79.3%) and males (60.01%). The incidence of perioperative stroke was 2.48%. CS (OR 1.8, 95%CI 1.1-2.8, p=0.009) and cerebral arterial occlusion (OR 3.4, 95% CI 1.3-8.9) significantly increased perioperative stroke risk following SAVR. Infective endocarditis (OR 4.6, 95%CI 3.8-5.6, p=0.00) and neurological disorders (OR 4.8, 95% CI 4-5.8, p=0.00) appeared to be the strongest risk factors for strokes. Other risk factors found to be significant predictors of perioperative strokes (p<0.05) were - age, higher VWR scores, CS, cerebral arterial occlusion, infective endocarditis, DM, HTN, renal failure, neurological disorders, coagulopathy and hypothyroidsm. In conclusion, perioperative stroke risk has remained more or less constant despite advancements in surgical techniques with risk having gone up in patients <65years of age. CS and cerebral arterial occlusion significantly increase stroke risk following SAVR. Improved patient selection with pre-operative risk stratification and institution of preventive strategies are necessary to improve operative outcomes following SAVR.
[Mh] Termos MeSH primário: Estenose da Valva Aórtica/epidemiologia
Valva Aórtica/cirurgia
Estenose das Carótidas/epidemiologia
Transtornos Cerebrovasculares/epidemiologia
Complicações Intraoperatórias/epidemiologia
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Comorbidade
Feminino
Próteses Valvulares Cardíacas
Seres Humanos
Incidência
Pacientes Internados
Masculino
Meia-Idade
Fatores de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28462683
[Au] Autor:Howard VJ; Meschia JF; Lal BK; Turan TN; Roubin GS; Brown RD; Voeks JH; Barrett KM; Demaerschalk BM; Huston J; Lazar RM; Moore WS; Wadley VG; Chaturvedi S; Moy CS; Chimowitz M; Howard G; Brott TG; CREST-2 study investigators
[Ad] Endereço:2 Department of Epidemiology (VJH), University of Alabama at Birmingham, Birmingham, AL, USA.
[Ti] Título:Carotid revascularization and medical management for asymptomatic carotid stenosis: Protocol of the CREST-2 clinical trials.
[So] Source:Int J Stroke;12(7):770-778, 2017 10.
[Is] ISSN:1747-4949
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rationale Trials conducted decades ago demonstrated that carotid endarterectomy by skilled surgeons reduced stroke risk in asymptomatic patients. Developments in carotid stenting and improvements in medical prevention of stroke caused by atherothrombotic disease challenge understanding of the benefits of revascularization. Aim Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) will test whether carotid endarterectomy or carotid stenting plus contemporary intensive medical therapy is superior to intensive medical therapy alone in the primary prevention of stroke in patients with high-grade asymptomatic carotid stenosis. Methods and design CREST-2 is two multicenter randomized trials of revascularization plus intensive medical therapy versus intensive medical therapy alone. One trial randomizes patients to carotid endarterectomy plus intensive medical therapy versus intensive medical therapy alone; the other, to carotid stenting plus intensive medical therapy versus intensive medical therapy alone. The risk factor targets of centrally directed intensive medical therapy are LDL cholesterol <70 mg/dl and systolic blood pressure <140 mmHg. Study outcomes The primary outcome is the composite of stroke and death within 44 days following randomization and stroke ipsilateral to the target vessel thereafter, up to four years. Change in cognition and differences in major and minor stroke are secondary outcomes. Sample size Enrollment of 1240 patients in each trial provides 85% power to detect a treatment difference if the event rate in the intensive medical therapy alone arm is 4.8% higher or 2.8% lower than an anticipated 3.6% rate in the revascularization arm. Discussion Management of asymptomatic carotid stenosis requires contemporary randomized trials to address whether carotid endarterectomy or carotid stenting plus intensive medical therapy is superior in preventing stroke beyond intensive medical therapy alone. Whether carotid endarterectomy or carotid stenting has favorable effects on cognition will also be tested. Trial registration United States National Institutes of Health Clinicaltrials.gov NCT02089217.
[Mh] Termos MeSH primário: Estenose das Carótidas/cirurgia
Endarterectomia das Carótidas
Acidente Vascular Cerebral/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estenose das Carótidas/complicações
Cognição
Feminino
Seres Humanos
Masculino
Meia-Idade
Risco
Acidente Vascular Cerebral/etiologia
Resultado do Tratamento
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1177/1747493017706238


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[PMID]:29205297
[Au] Autor:Lokuge K; de Waard DD; Halliday A; Gray A; Bulbulia R; Mihaylova B
[Ad] Endereço:Health Economics Research Centre, University of Oxford, Oxford, UK.
[Ti] Título:Meta-analysis of the procedural risks of carotid endarterectomy and carotid artery stenting over time.
[So] Source:Br J Surg;105(1):26-36, 2018 Jan.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stroke/death rates within 30 days of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in RCTs inform current clinical guidelines. However, the risks may have changed in recent years with wider use of effective stroke prevention therapies, especially statins, improved patient selection and growing operator expertise. The aim of this study was to investigate whether the procedural stroke/death risks from CEA and CAS have changed over time. METHODS: MEDLINE and Embase were searched systematically from inception to May 2016 for observational cohort studies of CEA and CAS. Studies included reported on more than 1000 patients, with 30-day outcomes after the procedure according to patients' symptom status (recent stroke or transient ischaemic attack). Restricted maximum likelihood random-effects and meta-regressions methods were used to synthesize procedural stroke/death rates of CEA and CAS according to year of study recruitment completion. RESULTS: Fifty-one studies, including 223 313 patients undergoing CEA and 72 961 undergoing CAS, were reviewed. Procedural stroke/death risks of CEA decreased over time in symptomatic and asymptomatic patients. Risks were substantially lower in studies completing recruitment in 2005 or later, both in symptomatic (5·11 per cent before 2005 versus 2·68 per cent from 2005 onwards; P = 0·002) and asymptomatic (3·17 versus 1·50 per cent; P < 0·001) patients. Procedural stroke/death rates of CAS did not change significantly over time (4·77 per cent among symptomatic and 2·59 per cent among asymptomatic patients). There was substantial heterogeneity in event rates and recruitment periods were long. CONCLUSIONS: Risks of procedural stroke/death following CEA appear to have decreased substantially. There was no evidence of a change in stroke/death rates following CAS.
[Mh] Termos MeSH primário: Estenose das Carótidas/cirurgia
Endarterectomia das Carótidas
Complicações Pós-Operatórias
Stents
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Endarterectomia das Carótidas/efeitos adversos
Endarterectomia das Carótidas/mortalidade
Seres Humanos
Modelos Estatísticos
Complicações Pós-Operatórias/epidemiologia
Risco
Stents/efeitos adversos
Acidente Vascular Cerebral/epidemiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10717


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[PMID]:28461597
[Au] Autor:Calvet D; Amar L; Rossi GP; Laurent S; Dominiczak AF; Turc G; Barigou M; Jennings G; Guzik T; Touyz RM
[Ad] Endereço:From the Department of Neurology, Centre Hospitalier Sainte-Anne, Université Paris Descartes, INSERM U894, DHU Neurovasc, Sorbonne Paris Cité, France (D.C., G.T.); University Paris Descartes, AP-HP, Hospital Europeen Georges Pompidou, France (L.A.); Clinica dell'Ipertensione, Department of Medicine,
[Ti] Título:Case of Asymptomatic Carotid Artery Stenosis in a Hypertensive Patient.
[So] Source:Hypertension;69(6):985-991, 2017 06.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Estenose das Carótidas/complicações
Hipertensão/complicações
[Mh] Termos MeSH secundário: Idoso
Anlodipino/uso terapêutico
Anti-Hipertensivos/uso terapêutico
Estenose das Carótidas/diagnóstico por imagem
Estenose das Carótidas/tratamento farmacológico
Diuréticos/uso terapêutico
Ecocardiografia Doppler
Seres Humanos
Hipertensão/tratamento farmacológico
Masculino
Perindopril/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Diuretics); 1J444QC288 (Amlodipine); Y5GMK36KGY (Perindopril)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.09330


  9 / 14053 MEDLINE  
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[PMID]:29340674
[Au] Autor:Lichtman JH; Howard G; Brott TG
[Ad] Endereço:Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
[Ti] Título:Trends in Carotid Revascularization Procedures-Reply.
[So] Source:JAMA;319(3):308-309, 2018 01 16.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Estenose das Carótidas
Endarterectomia das Carótidas
[Mh] Termos MeSH secundário: Seres Humanos
Stents
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19781


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[PMID]:29340671
[Au] Autor:Hussain MA; Bhatt DL; Al-Omran M
[Ad] Endereço:Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Trends in Carotid Revascularization Procedures.
[So] Source:JAMA;319(3):307-308, 2018 01 16.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Estenose das Carótidas
Endarterectomia das Carótidas
[Mh] Termos MeSH secundário: Seres Humanos
Stents
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.19773



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