Base de dados : MEDLINE
Pesquisa : C10.228.140.300.510.800 [Categoria DeCS]
Referências encontradas : 5068 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 507 ir para página                         

  1 / 5068 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29245288
[Au] Autor:Han JY; Kim HJ; Shin S; Park J; Lee IG
[Ad] Endereço:aDepartment of PediatricsbDepartment of RadiologycDepartment of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
[Ti] Título:Elevated serum lipoprotein(a) as a risk factor for combined intracranial and extracranial artery stenosis in a child with arterial ischemic stroke: A case report.
[So] Source:Medicine (Baltimore);96(49):e9025, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Stroke is an uncommon disease in childhood with an estimated incidence of 1 to 6 per 100,000 and stenoocclusive arteriopathy is the main risk factor of recurrent pediatric arterial ischemic stroke (AIS). Dyslipidemia may influence strongly before puberty and in late adolescence when plasma levels are naturally highest. PATIENT CONCERNS: An 11-year-old male presented with acute onset seizure, a drowsy mentality, and right hemiplegia. DIAGNOSES: Magnetic resonance (MR) angiogram demonstrated occlusion of distal basilar artery and left vertebral arteries. Serum Lp(a) was significantly increased as 269 nmol/L (normal<75 nmol/L) only. Thus, he was diagnosed as pediatric AIS. INTERVENTIONS: He was started on aspirin (100 mg/day) for secondary stroke prevention and received nicotinic acid (2 g/day) as a Lp(a)-lowering agent. OUTCOMES: Consciousness gradually improved and the patient regained a normal orientation after 2 weeks. The Lp(a) level was reduced to 48 nmol/L after nicotinic acid administration. LESSONS: High Lp(a) level may be considered in the risk profile assessment of pediatric AIS. Niacin and certain inhibitors of cholesteryl ester transfer protein can be considered to reduce Lp(a).
[Mh] Termos MeSH primário: Dislipidemias/complicações
Arteriosclerose Intracraniana/complicações
Lipoproteína(a)/sangue
Acidente Vascular Cerebral/complicações
[Mh] Termos MeSH secundário: Criança
Dislipidemias/tratamento farmacológico
Seres Humanos
Masculino
Niacina/uso terapêutico
Fatores de Risco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipoprotein(a)); 2679MF687A (Niacin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009025


  2 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29030476
[Au] Autor:Mossa-Basha M; Shibata DK; Hallam DK; de Havenon A; Hippe DS; Becker KJ; Tirschwell DL; Hatsukami T; Balu N; Yuan C
[Ad] Endereço:From the Department of Radiology (M.M.-B., D.K.S., D.K.H., D.S.H., N.B., C.Y.), Department of Neurology (K.J.B., D.L.T.), and Department of Surgery (T.H.), University of Washington, Seattle; and Department of Neurology, University of Utah, Salt Lake City (A.D.H.). mmossab@uw.edu.
[Ti] Título:Added Value of Vessel Wall Magnetic Resonance Imaging for Differentiation of Nonocclusive Intracranial Vasculopathies.
[So] Source:Stroke;48(11):3026-3033, 2017 Nov.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Our goal is to determine the added value of intracranial vessel wall magnetic resonance imaging (IVWI) in differentiating nonocclusive vasculopathies compared with luminal imaging alone. METHODS: We retrospectively reviewed images from patients with both luminal and IVWI to identify cases with clinically defined intracranial vasculopathies: atherosclerosis (intracranial atherosclerotic disease), reversible cerebral vasoconstriction syndrome, and inflammatory vasculopathy. Two neuroradiologists blinded to clinical data reviewed the luminal imaging of defined luminal stenoses/irregularities and evaluated the pattern of involvement to make a presumed diagnosis with diagnostic confidence. Six weeks later, the 2 raters rereviewed the luminal imaging in addition to IVWI for the pattern of wall involvement, presence and pattern of postcontrast enhancement, and presumed diagnosis and confidence. Analysis was performed on per-lesion and per-patient bases. RESULTS: Thirty intracranial atherosclerotic disease, 12 inflammatory vasculopathies, and 12 reversible cerebral vasoconstriction syndrome patients with 201 lesions (90 intracranial atherosclerotic disease, 64 reversible cerebral vasoconstriction syndrome, and 47 inflammatory vasculopathy lesions) were included. For both per-lesion and per-patient analyses, there was significant diagnostic accuracy improvement with luminal imaging+IVWI when compared with luminal imaging alone (per-lesion: 88.8% versus 36.1%; <0.001 and per-patient: 96.3% versus 43.5%; <0.001, respectively). There was substantial interrater diagnostic agreement for luminal imaging+IVWI (κ=0.72) and only slight agreement for luminal imaging (κ=0.04). Although there was a significant correlation for both luminal and IVWI pattern of wall involvement with diagnosis, there was a stronger correlation for IVWI finding of lesion eccentricity and intracranial atherosclerotic disease diagnosis than for luminal imaging (κ=0.69 versus 0.18; <0.001). CONCLUSIONS: IVWI can significantly improve the differentiation of nonocclusive intracranial vasculopathies when combined with traditional luminal imaging modalities.
[Mh] Termos MeSH primário: Arteriosclerose Intracraniana/diagnóstico por imagem
Angiografia por Ressonância Magnética/métodos
Vasculite do Sistema Nervoso Central/diagnóstico por imagem
Vasoespasmo Intracraniano/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.018227


  3 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28974628
[Au] Autor:Gory B; Piotin M; Haussen DC; Steglich-Arnholm H; Holtmannspötter M; Labreuche J; Taschner C; Eiden S; Nogueira RG; Papanagiotou P; Boutchakova M; Siddiqui A; Lapergue B; Dorn F; Cognard C; Killer-Oberpfalzer M; Mangiafico S; Ribo M; Behme D; Spiotta AM; Mazighi M; Turjman F; TITAN Investigators
[Ad] Endereço:From the Department of Interventional Neuroradiology, Hospices Civils de Lyon, France (B.G., F.T.); Department of Interventional Neuroradiology, Rothschild Foundation, Paris, France (M.P., M.M.); Departments of Neurology (H.S.A.) and Neuroradiology (M.H.), Rigshospitalet, Copenhagen, Denmark; Univer
[Ti] Título:Thrombectomy in Acute Stroke With Tandem Occlusions From Dissection Versus Atherosclerotic Cause.
[So] Source:Stroke;48(11):3145-3148, 2017 Nov.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Tandem steno-occlusive lesions were poorly represented in randomized trials and represent a major challenge for endovascular thrombectomy in acute anterior circulation strokes. The impact of the cervical carotid lesion cause (ie, atherosclerotic versus dissection) on outcome of tandem patients endovascularly treated remains to be assessed. METHODS: We retrospectively analyzed individual data of prospectively collected consecutive tandem patients treated with endovascular thrombectomy. The primary outcome was favorable outcome at 90 days (modified Rankin Scale score of 0-2). Secondary efficacy outcomes included successful reperfusion (modified Thrombolysis in Cerebrovascular Infarction scores of 2b-3), time to reperfusion, and safety outcomes encompassed procedural complications, symptomatic intracerebral hemorrhage, and 90-day mortality. RESULTS: Among the 295 included patients, 65 had cervical carotid dissection and 230 had cervical carotid atherosclerotic cause. The rate of favorable outcome was 56.3% in the dissection group versus 47.6% in the atherosclerotic arm (center-, age-, and admission National Institutes of Health Stroke Scale-adjusted odds ratio, 1.08; 95% confidence interval, 0.50-2.30; =0.85). No significant differences were observed in secondary outcomes. The rates of successful reperfusion, symptomatic intracerebral hemorrhage, and 90-day mortality were 78.5% versus 74.5% ( =0.13), 4.6% versus 5.2% ( =1.0), and 7.8% versus 15.3% ( =0.94) in the dissection versus atherosclerotic groups, respectively. The median procedural time was 76 minutes (interquartile range, 52-95 minutes) in the dissection group and 67 minutes (interquartile range, 45-98 minutes) in the atherosclerotic group ( =0.24). CONCLUSIONS: We found no differences in the outcomes of patients with anterior circulation tandem atherosclerotic and dissection lesions treated with endovascular thrombectomy. Further studies are warranted.
[Mh] Termos MeSH primário: Infarto Encefálico
Dissecação da Artéria Carótida Interna
Hemorragia Cerebral
Procedimentos Endovasculares
Acidente Vascular Cerebral
Trombectomia
[Mh] Termos MeSH secundário: Doença Aguda
Idoso
Infarto Encefálico/fisiopatologia
Infarto Encefálico/cirurgia
Dissecação da Artéria Carótida Interna/fisiopatologia
Dissecação da Artéria Carótida Interna/cirurgia
Hemorragia Cerebral/fisiopatologia
Hemorragia Cerebral/cirurgia
Seres Humanos
Arteriosclerose Intracraniana/fisiopatologia
Arteriosclerose Intracraniana/cirurgia
Meia-Idade
Estudos Retrospectivos
Acidente Vascular Cerebral/fisiopatologia
Acidente Vascular Cerebral/cirurgia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.018264


  4 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28945817
[Au] Autor:Lee SJ; Lee DG
[Ad] Endereço:Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
[Ti] Título:Distribution of atherosclerotic stenosis determining early neurologic deterioration in acute ischemic stroke.
[So] Source:PLoS One;12(9):e0185314, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Early neurologic deterioration (END) during the acute stage of stroke is clinically important because of its association with poor outcomes. The purpose of this study was (1) to investigate variables associated with END, (2) to determine the distribution of atherosclerotic stenosis associated with END, and (3) to clarify the relationship between END and clinical outcomes. METHODS: 516 patients with acute ischemic stroke were included. The median follow-up period was 31.7 months. END was defined as a ≥2 point increase in the National Institutes of Health Stroke Scale (NIHSS), ≥1 point increase in level of consciousness or motor item of the NIHSS, or the development of any new neurological deficits during the first 72 hours of hospitalization. A signal loss on 1.5-T magnetic resonance angiography exceeding 50% was considered to be significant for the categorization of stenosis pattern. RESULTS: The prevalence of END was 19.0%. END was associated with intracranial atherosclerotic stenosis (IAS) together with large artery atherosclerosis (LAA) subtype. In particular, stenosis of basilar artery or posterior cerebral artery was independently associated with END. Lesion growth or hypoperfusion was more accountable for END in patients with IAS, whereas intracerebral hemorrhage or edema/herniation was more frequently observed in END patients without IAS. Patients with END had a higher rate of mortality, but a similar rate of further vascular events compared to patients without END. CONCLUSION: Pre-stroke IAS and LAA subtype could determine the development of END during the acute stage of ischemic stroke.
[Mh] Termos MeSH primário: Isquemia Encefálica/patologia
Arteriosclerose Intracraniana/patologia
Acidente Vascular Cerebral/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Isquemia Encefálica/diagnóstico por imagem
Isquemia Encefálica/fisiopatologia
Feminino
Seres Humanos
Arteriosclerose Intracraniana/diagnóstico por imagem
Arteriosclerose Intracraniana/fisiopatologia
Angiografia por Ressonância Magnética
Masculino
Meia-Idade
Prognóstico
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Fatores de Risco
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185314


  5 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28939676
[Au] Autor:Baek JH; Yoo J; Song D; Kim YD; Nam HS; Heo JH
[Ad] Endereço:From the Department of Neurology, Yonsei University College of Medicine (J.-H.B., J.Y., D.S., Y.D.K., H.S.N., J.H.H.) and Department of Neurology, National Medical Center (J.-H.B.), Seoul, Republic of Korea.
[Ti] Título:The Protective Effect of Middle Cerebral Artery Calcification on Symptomatic Middle Cerebral Artery Infarction.
[So] Source:Stroke;48(11):3138-3141, 2017 Nov.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The presence of intracranial artery calcification is associated with an increased risk for stroke. However, calcified atherosclerotic plaques are also known to be less vulnerable to rupture. Given this discrepancy, we investigated whether the vulnerability of intracranial arterial atherosclerosis differed based on the presence or absence of calcification. METHODS: We considered consecutive patients with acute stroke in the unilateral middle cerebral artery (MCA) territory. Patients with any stenotic MCAs were included in this study. Symptomatic MCA was defined as the occurrence of infarctions relevant to the stenotic MCA. The presence of calcification in the MCA was evaluated on noncontrast thin-section computed tomography images using a 3dimensional software package. Generalized estimating equations were used to compare the frequency of calcification between symptomatic and asymptomatic stenosis. RESULTS: Of the 1066 MCAs examined in 533 patients, 645 MCAs were stenotic and were included in the study. Among the 645 stenotic MCAs, 406 MCAs (62.9%) were symptomatic. Calcification was observed in 36 MCAs (5.6%). Calcification in the MCA was more frequently observed in the asymptomatic group (7.9% versus 4.2%; =0.032). On multivariable analysis, the presence of calcification in MCA atherosclerosis was less frequent in the symptomatic group (odds ratio, 0.46; 95% confidence interval, 0.23-0.92; =0.027). CONCLUSIONS: This study showed that calcified atherosclerosis in the MCA was less frequently symptomatic.
[Mh] Termos MeSH primário: Infarto da Artéria Cerebral Média
Arteriosclerose Intracraniana
Artéria Cerebral Média
Sistema de Registros
Calcificação Vascular
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Seres Humanos
Infarto da Artéria Cerebral Média/epidemiologia
Infarto da Artéria Cerebral Média/patologia
Infarto da Artéria Cerebral Média/fisiopatologia
Arteriosclerose Intracraniana/epidemiologia
Arteriosclerose Intracraniana/patologia
Arteriosclerose Intracraniana/fisiopatologia
Masculino
Meia-Idade
Artéria Cerebral Média/patologia
Artéria Cerebral Média/fisiopatologia
Estudos Retrospectivos
Calcificação Vascular/epidemiologia
Calcificação Vascular/patologia
Calcificação Vascular/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017821


  6 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28830976
[Au] Autor:Saber H; Yakoob MY; Shi P; Longstreth WT; Lemaitre RN; Siscovick D; Rexrode KM; Willett WC; Mozaffarian D
[Ad] Endereço:From the Department of Neurology, Wayne State University School of Medicine, Detroit, MI (H.S.); Department of Epidemiology (H.S., M.Y.Y., W.C.W.) and Department of Nutrition (W.C.W.), Harvard T.H. Chan School of Public Health, Boston, MA; Tufts Friedman School of Nutrition Science and Policy, Bosto
[Ti] Título:Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts.
[So] Source:Stroke;48(10):2678-2685, 2017 Oct.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The associations of individual long-chain n-3 polyunsaturated fatty acids with incident ischemic stroke and its main subtypes are not well established. We aimed to investigate prospectively the relationship of circulating eicosapentaenoic acid, docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with risk of total ischemic, atherothrombotic, and cardioembolic stroke. METHODS: We measured circulating phospholipid fatty acids at baseline in 3 separate US cohorts: CHS (Cardiovascular Health Study), NHS (Nurses' Health Study), and HPFS (Health Professionals Follow-Up Study). Ischemic strokes were prospectively adjudicated and classified into atherothrombotic (large- and small-vessel infarctions) or cardioembolic by imaging studies and medical records. Risk according to fatty acid levels was assessed using Cox proportional hazards (CHS) or conditional logistic regression (NHS, HPFS) according to study design. Cohort findings were pooled using fixed-effects meta-analysis. RESULTS: A total of 953 incident ischemic strokes were identified (408 atherothrombotic, 256 cardioembolic, and 289 undetermined subtypes) during median follow-up of 11.2 years (CHS) and 8.3 years (pooled, NHS and HPFS). After multivariable adjustment, lower risk of total ischemic stroke was seen with higher DPA (highest versus lowest quartiles; pooled hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.58-0.92) and DHA (HR, 0.80; 95% CI, 0.64-1.00) but not eicosapentaenoic acid (HR, 0.94; 95% CI, 0.77-1.19). DHA was associated with lower risk of atherothrombotic stroke (HR, 0.53; 95% CI, 0.34-0.83) and DPA with lower risk of cardioembolic stroke (HR, 0.58; 95% CI, 0.37-0.92). Findings in each individual cohort were consistent with pooled results. CONCLUSIONS: In 3 large US cohorts, higher circulating levels of DHA were inversely associated with incident atherothrombotic stroke and DPA with cardioembolic stroke. These novel findings suggest differential pathways of benefit for DHA, DPA, and eicosapentaenoic acid.
[Mh] Termos MeSH primário: Isquemia Encefálica/sangue
Doenças Cardiovasculares/sangue
Ácidos Graxos Ômega-3/sangue
Embolia Intracraniana/sangue
Trombose Intracraniana/sangue
Acidente Vascular Cerebral/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Isquemia Encefálica/diagnóstico
Isquemia Encefálica/epidemiologia
Doenças Cardiovasculares/diagnóstico
Doenças Cardiovasculares/epidemiologia
Estudos de Casos e Controles
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Incidência
Arteriosclerose Intracraniana/sangue
Arteriosclerose Intracraniana/diagnóstico
Arteriosclerose Intracraniana/epidemiologia
Embolia Intracraniana/diagnóstico
Embolia Intracraniana/epidemiologia
Trombose Intracraniana/diagnóstico
Trombose Intracraniana/epidemiologia
Masculino
Meia-Idade
Estudos Prospectivos
Distribuição Aleatória
Fatores de Risco
Acidente Vascular Cerebral/diagnóstico
Acidente Vascular Cerebral/epidemiologia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Fatty Acids, Omega-3)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.018235


  7 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28798260
[Au] Autor:Kim BS; Chung PW; Park KY; Won HH; Bang OY; Chung CS; Lee KH; Kim GM
[Ad] Endereço:From the Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea (B.-S.K.); Department of Neurology, Samsung Medical Center (B.-S.K., O.Y.B., C.-S.C., K.H.L., G.-M.K) and Department of Neurology, Kangbuk Samsung Hospital (P.-W.C.), Sungkyunkwan University School of Medicine, Seoul
[Ti] Título:Burden of Intracranial Atherosclerosis Is Associated With Long-Term Vascular Outcome in Patients With Ischemic Stroke.
[So] Source:Stroke;48(10):2819-2826, 2017 Oct.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Ischemic stroke patients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS: This was a retrospective cohort study analyzing data from a prospective stroke registry enrolling consecutive patients with acute ischemic stroke or transient ischemic attack. A total of 1081 patients were categorized into no ICAS, single ICAS, and advanced ICAS (ICAS ≥2 different intracranial arteries) groups. Primary and secondary end points were time to occurrence of recurrent ischemic stroke and composite vascular outcome, respectively. Study end points by ICAS burden were compared using Cox proportional hazards models in overall and propensity-matched patients. RESULTS: ICAS was present in 405 patients (37.3%). During a median 5-year follow-up, recurrent stroke and composite vascular outcome occurred in 6.8% and 16.8% of patients, respectively. As the number of ICAS increased, the risk for study end points increased after adjustment of potential covariates (hazard ratio per 1 increase in ICAS, 1.19; 95% confidence interval, 1.01-1.42 for recurrent ischemic stroke and hazard ratio, 1.18; 95% confidence interval, 1.05-1.33 for composite vascular outcome). The hazard ratios (95% confidence interval) for recurrent stroke and composite vascular outcome in patients with advanced ICAS compared with those without ICAS were 1.56 (0.88-2.74) and 1.72 (1.17-2.53), respectively, in the overall patients. The corresponding values in the propensity-matched patients were 1.28 (0.71-2.30) and 1.95 (1.27-2.99), respectively. CONCLUSIONS: ICAS burden was independently associated with the risk of subsequent composite vascular outcome in patients with ischemic stroke. These findings suggest that ICAS burden can reflect the risk of long-term vascular outcome.
[Mh] Termos MeSH primário: Isquemia Encefálica/diagnóstico por imagem
Efeitos Psicossociais da Doença
Arteriosclerose Intracraniana/diagnóstico por imagem
Acidente Vascular Cerebral/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Isquemia Encefálica/epidemiologia
Estudos de Coortes
Feminino
Seres Humanos
Arteriosclerose Intracraniana/epidemiologia
Estudos Longitudinais
Masculino
Meia-Idade
Estudos Prospectivos
Sistema de Registros
Estudos Retrospectivos
Acidente Vascular Cerebral/epidemiologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170812
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017806


  8 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28734077
[Au] Autor:Mahdessian H; Perisic Matic L; Lengquist M; Gertow K; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Hamsten A; Eriksson P; Hedin U; Mälarstig A; IMPROVE study group
[Ad] Endereço:Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
[Ti] Título:Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke.
[So] Source:J Intern Med;282(5):429-444, 2017 Nov.
[Is] ISSN:1365-2796
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ischaemic stroke and coronary heart disease are important contributors to the global disease burden and share atherosclerosis as the main underlying cause. Recent evidence from a genome-wide association study (GWAS) suggested that single nucleotide polymorphisms (SNP) near the MMP12 gene at chromosome 11q22.3 were associated with large-vessel ischaemic stroke. Here, we evaluated and extended these results by examining the relationship between MMP12 and atherosclerosis in clinical and experimental studies. METHODS AND RESULTS: Plasma concentrations of MMP12 were measured at baseline in 3394 subjects with high-risk for cardiovascular disease (CVD) using the Olink ProSeek CVD I array. The plasma MMP12 concentration showed association with incident cardiovascular and cerebrovascular events (130 and 67 events, respectively, over 36 months) and carotid intima-media thickness progression (P = 3.6 × 10 ). A GWAS of plasma MMP12 concentrations revealed that SNPs rs499459, rs613084 and rs1892971 at chr11q22.3 were independently associated with plasma MMP12 (P < 5 × 10 ). The lead SNPs showed associations with mRNA levels of MMP12 and adjacent MMPs in atherosclerotic plaques. MMP12 transcriptomic and proteomic levels were strongly significantly increased in carotid plaques compared with control arterial tissue and in plaques from symptomatic versus asymptomatic patients. By combining immunohistochemistry and proximity ligation assay, we demonstrated that MMP12 localizes to CD68 + macrophages and interacts with elastin in plaques. MMP12 silencing in human THP-1-derived macrophages resulted in reduced macrophage migration. CONCLUSIONS: Our study supports the notion that MMP12 is implicated in large-artery atherosclerotic stroke, functionally by enhancing elastin degradation and macrophage invasion in plaques.
[Mh] Termos MeSH primário: Arteriosclerose Intracraniana/genética
Metaloproteinase 12 da Matriz/genética
Acidente Vascular Cerebral/genética
[Mh] Termos MeSH secundário: Espessura Intima-Media Carotídea
Feminino
Seres Humanos
Masculino
Metaloproteinase 12 da Matriz/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.65 (Matrix Metalloproteinase 12)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE
[do] DOI:10.1111/joim.12655


  9 / 5068 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28723788
[Au] Autor:Wang MY; Liu YS; Li K; Liu YJ; Wang F
[Ad] Endereço:Department of Intervention Therapy, First Affiliated Hospital of Dalian Medical University, Dalian, China.
[Ti] Título:Protective effect of the microcatheter placed at the normal vertebral artery in intracranial stent-assisted angioplasty for vertebral artery stenosis: A case report.
[So] Source:Medicine (Baltimore);96(29):e7569, 2017 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A carefully designed intracranial stent-assisted angioplasty (SAA) is presented here that may prevent subsequent branch artery occlusion. PATIENT CONCERNS: A 72-year-old man with a 3-month history of progressive and intermittent vertigo without any obvious trigger, accompanied by nausea. DIAGNOSES: Intracranial atherosclerotic disease. INTERVENTIONS: the patient underwent intracranial SAA in accordance with the procedure described here. OUTCOMES: The patient's paroxysmal vertigo completely subsided, with no complications during the short-term follow-up. LESSONS: This novel intracranial SAA procedure is safe and may reduce the risk of subsequent artery occlusion.
[Mh] Termos MeSH primário: Angioplastia com Balão
Arteriosclerose Intracraniana/cirurgia
Stents
Artéria Vertebral/cirurgia
Insuficiência Vertebrobasilar/cirurgia
[Mh] Termos MeSH secundário: Idoso
Cateteres de Demora
Seres Humanos
Arteriosclerose Intracraniana/complicações
Arteriosclerose Intracraniana/diagnóstico
Arteriosclerose Intracraniana/tratamento farmacológico
Masculino
Artéria Vertebral/diagnóstico por imagem
Insuficiência Vertebrobasilar/complicações
Insuficiência Vertebrobasilar/diagnóstico
Insuficiência Vertebrobasilar/tratamento farmacológico
Vertigem/diagnóstico
Vertigem/tratamento farmacológico
Vertigem/etiologia
Vertigem/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007569


  10 / 5068 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28701579
[Au] Autor:Harteveld AA; van der Kolk AG; van der Worp HB; Dieleman N; Zwanenburg JJM; Luijten PR; Hendrikse J
[Ad] Endereço:From the Department of Radiology (A.A.H., A.G.v.d.K., N.D., J.J.M.Z., P.R.L., J.H.) and Department of Neurology and Neurosurgery (H.B.v.d.W.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands. a.a.harteveld-2@umcutrecht.nl.
[Ti] Título:Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging: Patients With Posterior Circulation Ischemia Versus Healthy Controls.
[So] Source:Stroke;48(9):2601-2604, 2017 Sep.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Vessel wall magnetic resonance imaging sequences have been developed to directly visualize the intracranial vessel wall, enabling detection of vessel wall changes, including those that have not yet caused luminal narrowing. In this study, vessel wall lesion burden was assessed in patients with recent posterior circulation ischemia using 7T-magnetic resonance imaging and compared with matched healthy controls. METHODS: Fifty subjects (25 patients and 25 matched healthy controls) underwent 7T-magnetic resonance imaging with an intracranial vessel wall sequence before and after contrast administration. Two raters scored the presence and contrast enhancement of arterial wall lesions in individual segments of the circle of Willis and its primary branches. Total burden and distribution of vessel wall lesions and lesion characteristics (configuration, thickening pattern, and contrast enhancement) were compared both between and within both groups. RESULTS: Overall, vessel wall lesion burden and distribution were comparable between patients and controls. Regarding individual arterial segments, only vessel wall lesions in the posterior cerebral artery were more frequently observed in patients (18.0%) than in controls (5.4%; =0.003). Many of these lesions showed enhancement, both in patients (48.9%) and in controls (43.5%; =0.41). In patients, the proportion of enhancing lesions was higher in the posterior circulation (53.3%) than in the anterior circulation (20.6%; =0.008). CONCLUSIONS: Although overall intracranial vessel wall lesion burden and contrast enhancement were comparable between patients with recent posterior circulation ischemia and healthy controls, this study also revealed significant differences between the 2 groups, suggesting an association between posterior circulation lesion burden/enhancement and ischemic events. CLINICAL TRIAL REGISTRATION: URL: http://www.trialregister.nl. Unique identifier: NTR5688.
[Mh] Termos MeSH primário: Artéria Cerebral Anterior/diagnóstico por imagem
Isquemia Encefálica/diagnóstico por imagem
Círculo Arterial do Cérebro/diagnóstico por imagem
Arteriosclerose Intracraniana/diagnóstico por imagem
Artéria Cerebral Posterior/diagnóstico por imagem
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Meios de Contraste
Seres Humanos
Ataque Isquêmico Transitório/diagnóstico por imagem
Imagem por Ressonância Magnética
Acidente Vascular Cerebral/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017868



página 1 de 507 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde