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[PMID]:29480825
[Au] Autor:Jang SH; Jang WH
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Daegu.
[Ti] Título:The allocentric neglect due to injury of the inferior fronto-occipital fasciculus in a stroke patient: A case report.
[So] Source:Medicine (Baltimore);97(2):e9295, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a patient who developed allocentric neglect due to injury of the inferior fronto-occipital fasciculus (IFOF) following intracranial hemorrhage, diagnosed using diffusion tensor tractography (DTT). PATIENT CONCERNS: Her cognition seemed normal (A 17-year-old, right-handed female patient). However, in spite of a normal visual field, her perception was missing on the left side, and she had no awareness of her deficit. She was unable to perceive the left side in each of 2 objects, regardless of position of the 2 objects, and failed at detail exploration of the left side of 1 object. In addition, the line bisection test, the most representative neglect test, did not reveal any abnormality. DIAGNOSES: She was diagnosed with an intracerebral hemorrhage (right thalamus), intraventricular hemorrhage, and subarachnoid hemorrhage due to arteriovenous malformation in the right thalamus. INTERVENTIONS: Seven weeks after onset, she began rehabilitation. Consequently, the apple cancellation test to discriminate between allocentric and egocentric neglect was performed, with the result of severe allocentric neglect. OUTCOMES: The right superior longitudinal fasciculus and inferior longitudinal fasciculus were well-reconstructed without definite injury compared with those of the left side. However, the right IFOF was discontinued in the anterior portion around the frontal lobe. LESSONS: Allocentric neglect due to injury of IFOF was demonstrated in a stroke patient using DTT. It appears that DTT would be helpful in demonstrating the neglect type and pathway in patients with neglect.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Hemorragia Cerebral/complicações
Malformações Arteriovenosas Intracranianas/complicações
Transtornos da Percepção/etiologia
Acidente Vascular Cerebral/complicações
Hemorragia Subaracnóidea/complicações
[Mh] Termos MeSH secundário: Adolescente
Encéfalo/fisiopatologia
Hemorragia Cerebral/diagnóstico por imagem
Hemorragia Cerebral/fisiopatologia
Imagem de Tensor de Difusão
Feminino
Seres Humanos
Malformações Arteriovenosas Intracranianas/diagnóstico por imagem
Malformações Arteriovenosas Intracranianas/fisiopatologia
Vias Neurais/lesões
Vias Neurais/fisiopatologia
Transtornos da Percepção/diagnóstico por imagem
Transtornos da Percepção/fisiopatologia
Transtornos da Percepção/reabilitação
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/fisiopatologia
Hemorragia Subaracnóidea/diagnóstico por imagem
Hemorragia Subaracnóidea/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009295


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[PMID]:29206387
[Ti] Título:Zach's Story: An internal look at provider's AVM experience.
[So] Source:JEMS;41(12):60, 2016 12.
[Is] ISSN:0197-2510
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Pessoal Técnico de Saúde
Malformações Arteriovenosas Intracranianas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29206385
[Au] Autor:Girardeau RP
[Ti] Título:Vascular tangles: Recognizing and understanding arteriovenous malformations.
[So] Source:JEMS;41(12):57-9, 2016 12.
[Is] ISSN:0197-2510
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Serviços Médicos de Emergência
Malformações Arteriovenosas Intracranianas/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Malformações Arteriovenosas Intracranianas/etiologia
Malformações Arteriovenosas Intracranianas/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:28454721
[Au] Autor:Fahed R; Batista AL; Darsaut TE; Gentric JC; Ducroux C; Chaalala C; Roberge D; Bojanowski MW; Weill A; Roy D; Magro E; Raymond J
[Ad] Endereço:Centre Hospitalier de l'Université de Montréal (CHUM), Notre-Dame Hospital, Department of Radiology, 1560 Sherbrooke East, Pavilion Simard, suite Z12909, H2L 4M1 Montreal, Quebec, Canada.
[Ti] Título:The Treatment of Brain Arteriovenous Malformation Study (TOBAS): A preliminary inter- and intra-rater agreement study on patient management.
[So] Source:J Neuroradiol;44(4):247-253, 2017 Jul.
[Is] ISSN:0150-9861
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:OBJECT: The best management of brain arteriovenous malformation (bAVM) patients remains unknown. Randomized allocation may be more readily accepted when there is uncertainty and disagreement regarding the management of potential participants. In planning for a trial, we aimed to assess variability and agreement among physicians managing bAVM patients. METHODS: A portfolio composed of 35 patients was sent to 47 clinicians of various specialties managing bAVM patients. For each patient, physicians were asked their best management decision (surgery/embolization/radiosurgery/conservative), their confidence level, and whether they would include the patient in a randomized trial comparing conservative and curative management. Seven physicians, who had access to all images of each patient, independently responded twice, to assess inter and intra-rater agreement using kappa statistics. RESULTS: The inter-rater agreement (30 raters, including 16 neuroradiologists) for best management decision was only "fair" (κ [95%CI]=0.210[0.157; 0.295]). Agreement remained below 'substantial' (κ<.6) between physicians of the same specialty, and when no distinctions were made between various treatments (when responses were dichotomized as conservative versus curative). With access to all images the inter-rater agreement remained fair. The intra-rater agreement reached "substantial" only for the dichotomized decisions. Responding clinicians were willing to include 54.4% of patients (mainly unruptured bAVMs) in a randomized trial. CONCLUSION: There is a lack of agreement among clinicians involved in the management of bAVM patients. In this study a substantial proportion of clinicians were willing to offer randomized allocation of management options to a substantial number of patients.
[Mh] Termos MeSH primário: Malformações Arteriovenosas Intracranianas/diagnóstico por imagem
Malformações Arteriovenosas Intracranianas/terapia
Neuroimagem/métodos
Padrões de Prática Médica
[Mh] Termos MeSH secundário: Adulto
Tomada de Decisões
Feminino
Seres Humanos
Masculino
Meia-Idade
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28953623
[Au] Autor:Zhou Q; Li M; Yi L; He B; Li X; Jiang Y
[Ad] Endereço:aDepartment of Neurosurgery bDepartment of Neurosurgery Neurophysiology Center, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
[Ti] Título:Intraoperative neuromonitoring during brain arteriovenous malformation microsurgeries and postoperative dysfunction: A retrospective follow-up study.
[So] Source:Medicine (Baltimore);96(39):e8054, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To evaluate the effectiveness of intraoperative neuromonitoring (IONM) during arteriovenous malformation (AVM) surgery, we retrospectively analyzed neurologic dysfunction in patients who underwent AVM surgery with (IONM group) and without IONM (non-IONM group). The sensitivity and specificity of short-term neurologic dysfunction were calculated in the IONM group. IONM parameters were obtained in all patients. There was no significant difference in neurologic dysfunction between patients in the IONM and non-IONM groups. The short-term hemiplegia ratio among grade III patients in the IONM group was significantly lower than the non-IONM group. The sensitivity of IONM for predicting short-term neurologic dysfunction in the IONM group was 86.7% with a specificity of 100%. Of the different parameters monitored intraoperatively, the somatosensory-evoked potential (SEP), maximum expiratory pressure (MEP), and brain auditory-evoked potential (BAEP) may be beneficial in grade III and IV patients. The BAEP complemented the SEP and MEP. Electromyography and the visual-evoked potential have promise in preserving cranial nerve and visual function. For grades I and II patients, no SEP monitoring was safe. For grade V patients, further investigation is required to prevent neurologic dysfunction because of highly related risks for disability and postoperative complications. Moreover, a larger sample size is required to demonstrate the usefulness of IONM during awake craniotomies.
[Mh] Termos MeSH primário: Malformações Arteriovenosas Intracranianas/cirurgia
Monitorização Neurofisiológica Intraoperatória/métodos
Microcirurgia/efeitos adversos
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Potenciais Evocados Auditivos do Tronco Encefálico
Potenciais Somatossensoriais Evocados
Feminino
Seguimentos
Hemiplegia/diagnóstico
Seres Humanos
Masculino
Pressões Respiratórias Máximas
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008054


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[PMID]:28949989
[Au] Autor:Raoufi-Rad N; McRobb LS; Lee VS; Bervini D; Grace M; Ukath J; Mchattan J; Sreenivasan VKA; Duong TTH; Zhao Z; Stoodley MA
[Ad] Endereço:Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.
[Ti] Título:In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation.
[So] Source:PLoS One;12(9):e0185393, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Focussed radiosurgery may provide a means of inducing molecular changes on the luminal surface of diseased endothelium to allow targeted delivery of novel therapeutic compounds. We investigated the potential of ionizing radiation to induce surface expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) on endothelial cells (EC) in vitro and in vivo, to assess their suitability as vascular targets in irradiated arteriovenous malformations (AVMs). Cultured brain microvascular EC were irradiated by linear accelerator at single doses of 0, 5, 15 or 25 Gy and expression of ICAM-1 and VCAM-1 measured by qRT-PCR, Western, ELISA and immunocytochemistry. In vivo, near-infrared (NIR) fluorescence optical imaging using Xenolight 750-conjugated ICAM-1 or VCAM-1 antibodies examined luminal biodistribution over 84 days in a rat AVM model after Gamma Knife surgery at a single 15 Gy dose. ICAM-1 and VCAM-1 were minimally expressed on untreated EC in vitro. Doses of 15 and 25 Gy stimulated expression equally; 5 Gy was not different from the unirradiated. In vivo, normal vessels did not bind or retain the fluorescent probes, however binding was significant in AVM vessels. No additive increases in probe binding were found in response to radiosurgery at a dose of 15 Gy. In summary, radiation induces adhesion molecule expression in vitro but elevated baseline levels in AVM vessels precludes further induction in vivo. These molecules may be suitable targets in irradiated vessels without hemodynamic derangement, but not AVMs. These findings demonstrate the importance of using flow-modulated, pre-clinical animal models for validating candidate proteins for vascular targeting in irradiated AVMs.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Molécula 1 de Adesão Intercelular/metabolismo
Malformações Arteriovenosas Intracranianas/metabolismo
Malformações Arteriovenosas Intracranianas/cirurgia
Radiocirurgia/métodos
Molécula 1 de Adesão de Célula Vascular/metabolismo
[Mh] Termos MeSH secundário: Animais
Endotélio Vascular/citologia
Endotélio Vascular/metabolismo
Masculino
Camundongos
Dosagem Radioterapêutica
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vascular Cell Adhesion Molecule-1); 126547-89-5 (Intercellular Adhesion Molecule-1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185393


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[PMID]:28906387
[Au] Autor:Friedmann AJ
[Ad] Endereço:Department of Kinesiology, Recreation, and Sport, Indiana State University, Terre Haute, IN, USA.
[Ti] Título:A nearly full-recovery from AVM hemorrhagic stroke 17 years after insult using a new integrated neurodevelopmental approach: A case report.
[So] Source:Medicine (Baltimore);96(37):e8026, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONAL: With the prevalence of stroke increasing in the USA and the world along with increased survival and longevity due to medical advancements, it has become increasingly necessary to look at the chronic phase of stroke recovery. Previous paradigms of stroke treatment have proven ineffective when looking at 10, 15, or 20 years of survival post insult. PATIENT CONCERNS: The patient, being a young man just out of high school, was concerned with his overall morbidity. He was highly concerned with the quality of life he could expect as a stroke survivor with a life expectancy of 60 years or more. DIAGNOSES: C was diagnosed with a hemorrhagic AVM stroke that impacted several regions of the brain, particularly the right occipital and temporal lobes as well as bilateral motor control. C experienced severe hpertonicity of the musculature and significant vertigo. INTERVENTIONS: This study investigated a novel approach to chronic-phase stroke rehabilitation using traditional child motor-learning techniques, play, and proprioceptive-building activities in addition to current stroke rehabilitation techniques. During an initial six-month period, followed by a three-year period, the participant used motor-developmental learning activities as well as traditional strength, gait, and balance training. During the initial phase of treatment, clinically-significant improvements were recorded along with self-reported lifestyle enhancements. These gains continued throughout the three-and-a-half year process. OUTCOMES: C regained the ability to free-walk in small bouts and went from the use of a walker to canes. He regained use of his hands and removed a large partion of his vertigo. Of specific interest was the participant's ability to progress from using a walker to driving, returning to school, and starting a family. LESSONS: This study lays the groundwork for future studies into this type of therapeutic approach as well as highlighting the ability of chronic-phase stroke patients to recover well into the second decade post stroke. After the initial six month period, as gains were being observed, a more formal measurement process was begun for a second six-month period. Initial measurements of progress were taken every six weeks using the Fugl-Meyer test, the Berg Balance Test, the Barthel Index, and the Stroke Specific Quality Of Life scale. Results showed clinically significant improvements in all areas of recovery.
[Mh] Termos MeSH primário: Malformações Arteriovenosas Intracranianas/complicações
Hemorragias Intracranianas/complicações
Reabilitação do Acidente Vascular Cerebral/métodos
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Seguimentos
Seres Humanos
Masculino
Indução de Remissão
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008026


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[PMID]:28878048
[Au] Autor:Mohr JP; Overbey JR; von Kummer R; Stefani MA; Libman R; Stapf C; Parides MK; Pile-Spellman J; Moquete E; Moy CS; Vicaut E; Moskowitz AJ; Harkness K; Cordonnier C; Biondi A; Houdart E; Berkefeld J; Klijn CJM; Barreau X; Kim H; Hartmann A; International ARUBA Investigators
[Ad] Endereço:From Columbia University Medical Center (J.P.M.); Icahn School of Medicine at Mount Sinai (J.R.O., M.K.P., E.M., A.J.M.), New York, NY; University Hospital Dresden (R.v.K.), Germany; Federal University of Rio Grande do Sul (M.A.S.), Porto Alegre, Brazil; North Shore-Long Island Jewish Medical Center
[Ti] Título:Functional impairments for outcomes in a randomized trial of unruptured brain AVMs.
[So] Source:Neurology;89(14):1499-1506, 2017 Oct 03.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA). METHODS: We used the initial results of a nonblinded, randomized, controlled, parallel-group trial involving adults ≥18 years of age with an unruptured brain arteriovenous malformation (AVM) to compare the effects of medical management (MM) with or without interventional therapy (IT) on functional impairment, defined by a primary outcome of death or symptomatic stroke causing modified Rankin Scale (mRS) score ≥2. ARUBA closed recruitment on April 15, 2013. RESULTS: After a median of 33.3 months of follow-up (interquartile range 16.3-49.8 months), of the 223 enrolled in the trial, those in the MM arm were less likely to experience primary outcomes with an mRS score ≥2 than those who underwent IT. The results applied for both those as randomized (MM n = 109 vs IT n = 114) (hazard ratio [HR] 0.25, 95% confidence interval [CI] 0.11-0.57, = 0.001) and as treated (MM n = 125 vs IT n = 98) (HR 0.10, 95% CI 0.04-0.28, < 0.001). Functional impairment for the outcomes showed no significant difference by Spetzler-Martin grade for MM but was more frequent with increasing grades for IT ( < 0.001). CONCLUSION: Death or stroke with functional impairment in ARUBA after a median follow-up of 33 months was significantly lower for those in the MM arm both as randomized and as treated compared with those with IT. Functional severity of outcomes was lower in the MM arm, regardless of Spetzler-Martin grades. CLINICALTRIALSGOV IDENTIFIER: NCT00389181. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for adults with unruptured brain AVMs, interventional management compared to MM increases the risk of disability and death over ≈3 years.
[Mh] Termos MeSH primário: Embolização Terapêutica/efeitos adversos
Malformações Arteriovenosas Intracranianas/tratamento farmacológico
Malformações Arteriovenosas Intracranianas/cirurgia
Complicações Pós-Operatórias/etiologia
Resultado do Tratamento
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seguimentos
Seres Humanos
Malformações Arteriovenosas Intracranianas/diagnóstico por imagem
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004532


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[PMID]:28855391
[Au] Autor:Chen X; Cooke DL; Saloner D; Nelson J; Su H; Lawton MT; Hess C; Tihan T; Zhao Y; Kim H
[Ad] Endereço:From Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research (X.C., J.N., H.S., H.K.), Department of Radiology and Biomedical Imaging (D.L.C., D.S., C.H.), Department of Neurological Surgery (M.T.L.), and Department of Pathology (T.T.), University of California, San Fran
[Ti] Título:Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages.
[So] Source:Stroke;48(10):2881-2884, 2017 Oct.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Silent microhemorrhage (hemosiderin) has been observed in resected brain arteriovenous malformations (bAVM) tissue and may represent a subgroup at increased risk for clinical hemorrhage. Previous studies suggest that ruptured bAVMs have faster flow and shorter mean transit time of contrast in blood vessels than unruptured bAVMs. We hypothesized that flow would be faster in unruptured AVMs with hemosiderin compared with those without hemosiderin. METHODS: We selected unruptured, supratentorial bAVMs >3.5 cc with pathology specimens. Hemodynamic features were evaluated using color-coding angiography, including contrast mean transit time of AVM nidus, time to peak (TTP) of feeding artery (FA) and draining vein (DV), and the ratio (TTP DV/FA). Characteristics of 9 cases with hemosiderin and 16 without hemosiderin were compared using 2-sample tests and Fisher exact tests. RESULTS: No difference in FA TTP and DV TTP was observed between groups. However, cases with hemosiderin had significantly shorter mean transit time compared with those without hemosiderin (1.11±0.28 versus 1.64±0.55 seconds; =0.013) and a lower ratio of DV TTP/FA TTP (1.48±0.32 versus 1.94±0.61; =0.045). Presence of venous varix was significantly associated with hemosiderin ( =0.003). No other clinical or angioarchitectural factors were associated with hemosiderin. CONCLUSIONS: Shorter mean transit time through the AVM nidus, lower DV TTP/FA TTP, and the high prevalence of venous varices suggests that high flow is an important feature of unruptured bAVMs with hemosiderin.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Hemorragia Cerebral/diagnóstico por imagem
Malformações Arteriovenosas Intracranianas/diagnóstico por imagem
Microvasos/diagnóstico por imagem
Microvasos/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Angiografia Digital/métodos
Hemorragia Cerebral/epidemiologia
Feminino
Seres Humanos
Malformações Arteriovenosas Intracranianas/epidemiologia
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017785


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[PMID]:28802071
[Au] Autor:Huang J; Song J; Qu M; Wang Y; An Q; Song Y; Yan W; Wang B; Wang X; Zhang S; Chen X; Zhao B; Liu P; Xu T; Zhang Z; Greenberg DA; Wang Y; Gao P; Zhu W; Yang GY
[Ad] Endereço:Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai JiaoTong University School of Medicine, Shanghai, China.
[Ti] Título:MicroRNA-137 and microRNA-195* inhibit vasculogenesis in brain arteriovenous malformations.
[So] Source:Ann Neurol;82(3):371-384, 2017 Sep.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Brain arteriovenous malformations (AVMs) are the most common cause of nontraumatic intracerebral hemorrhage in young adults. The genesis of brain AVM remains enigmatic. We investigated microRNA (miRNA) expression and its contribution to the pathogenesis of brain AVMs. METHODS: We used a large-scale miRNA analysis of 16 samples including AVMs, hemangioblastoma, and controls to identify a distinct AVM miRNA signature. AVM smooth muscle cells (AVMSMCs) were isolated and identified by flow cytometry and immunohistochemistry, and candidate miRNAs were then tested in these cells. Migration, tube formation, and CCK-8-induced proliferation assays were used to test the effect of the miRNAs on phenotypic properties of AVMSMCs. A quantitative proteomics approach was used to identify protein expression changes in AVMSMCs treated with miRNA mimics. RESULTS: A distinct AVM miRNA signature comprising a large portion of lowly expressed miRNAs was identified. Among these miRNAs, miR-137 and miR-195* levels were significantly decreased in AVMs and constituent AVMSMCs. Experimentally elevating the level of these microRNAs inhibited AVMSMC migration, tube formation, and survival in vitro and the formation of vascular rings in vivo. Proteomics showed the protein expression signature of AVMSMCs and identified downstream proteins regulated by miR-137 and miR-195* that were key signaling proteins involved in vessel development. INTERPRETATION: Our results indicate that miR-137 and miR-195* act as vasculogenic suppressors in AVMs by altering phenotypic properties of AVMSMCs, and that the absence of miR-137 and miR-195* expression leads to abnormal vasculogenesis. Ann Neurol 2017;82:371-384.
[Mh] Termos MeSH primário: Fístula Arteriovenosa/patologia
Hemangioblastoma/patologia
Malformações Arteriovenosas Intracranianas/patologia
MicroRNAs/metabolismo
Neovascularização Patológica/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fístula Arteriovenosa/genética
Fístula Arteriovenosa/metabolismo
Movimento Celular/fisiologia
Proliferação Celular/fisiologia
Feminino
Perfilação da Expressão Gênica
Hemangioblastoma/genética
Hemangioblastoma/metabolismo
Seres Humanos
Malformações Arteriovenosas Intracranianas/genética
Malformações Arteriovenosas Intracranianas/metabolismo
Masculino
MicroRNAs/genética
Meia-Idade
Neovascularização Patológica/genética
Neovascularização Patológica/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN137 microRNA, human); 0 (MIRN195 microRNA, human); 0 (MicroRNAs)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1002/ana.25015



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