Base de dados : MEDLINE
Pesquisa : C10.228.140.430.520 [Categoria DeCS]
Referências encontradas : 63 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 7 ir para página                  

  1 / 63 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28331857
[Au] Autor:Ruhnau J; Schulze J; Dressel A; Vogelgesang A
[Ad] Endereço:Department of Neurology, University Medicine Greifswald, Greifswald, Germany.
[Ti] Título:Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke.
[So] Source:J Immunol Res;2017:5140679, 2017.
[Is] ISSN:2314-7156
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Immune cells can significantly predict and affect the clinical outcome of stroke. In particular, the neutrophil-to-lymphocyte ratio was shown to predict hemorrhagic transformation and the clinical outcome of stroke; however, the immunological mechanisms underlying these effects are poorly understood. Neutrophils are the first cells to invade injured tissue following focal brain ischemia. In these conditions, their proinflammatory properties enhance tissue damage and may promote ischemic incidences by inducing thrombus formation. Therefore, they constitute a potential target for therapeutic approaches and prevention of stroke. Indeed, in animal models of focal brain ischemia, neutrophils have been targeted with successful results. However, even in brain lesions, neutrophils also exert beneficial effects, because they are involved in triggering immunological removal of cell debris. Furthermore, intact neutrophil function is essential for maintaining immunological defense against bacterial infections. Several studies have demonstrated that stroke-derived neutrophils displayed impaired bacterial defense capacity. Because infections are known to impair the clinical course of stroke, therapeutic interventions that target neutrophils should preserve or even restore their function outside the central nervous system (CNS). This complex situation requires well-tailored therapeutic approaches that can effectively tackle immune cell invasion in the brain but avoid increasing poststroke infections.
[Mh] Termos MeSH primário: Encefalite/etiologia
Neutrófilos/imunologia
Acidente Vascular Cerebral/complicações
Trombose/etiologia
[Mh] Termos MeSH secundário: Animais
Isquemia Encefálica/etiologia
Isquemia Encefálica/patologia
Encefalite/metabolismo
Encefalite/patologia
Encefalite/terapia
Seres Humanos
Encefalite Infecciosa
Contagem de Leucócitos
Infiltração de Neutrófilos
Neutrófilos/metabolismo
Neutrófilos/patologia
Oxirredução
Estresse Oxidativo
Espécies Reativas de Oxigênio/metabolismo
Acidente Vascular Cerebral/imunologia
Acidente Vascular Cerebral/metabolismo
Acidente Vascular Cerebral/terapia
Trombose/metabolismo
Trombose/patologia
Trombose/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Reactive Oxygen Species)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1155/2017/5140679


  2 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28226078
[Au] Autor:Silva HM; Vinaud MC; Lino RS
[Ad] Endereço:Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia GO, Brasil.
[Ti] Título:Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis.
[So] Source:Arq Neuropsiquiatr;75(2):96-102, 2017 Feb.
[Is] ISSN:1678-4227
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Methods: BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results: The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema. The IL-4-KO animals, in the late phase of the infection, showed lower intensity of ventriculomegaly, encephalitis, and meningitis, and greater survival of the parasites in comparison with the WT animals. Conclusion: The absence of IL-4 induced lower inflammatory infiltration, ventriculomegaly and perivasculitis in experimental NCC.
[Mh] Termos MeSH primário: Encéfalo/parasitologia
Cysticercus/fisiologia
Encefalite Infecciosa/parasitologia
Interleucina-4/sangue
Neurocisticercose/parasitologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Interações Hospedeiro-Parasita
Encefalite Infecciosa/sangue
Camundongos
Camundongos Endogâmicos BALB C
Neurocisticercose/sangue
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
207137-56-2 (Interleukin-4)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


  3 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28183731
[Au] Autor:Engen RM; Killien EY; Davis JL; Symons JM; Hartmann SM
[Ad] Endereço:Departments of Pediatrics, and rachel.engen@seattlechildrens.org.
[Ti] Título: Complicating Hemolytic Uremic Syndrome: Survival Without Surgical Intervention.
[So] Source:Pediatrics;139(3), 2017 Mar.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:is an anaerobic bacterium that causes rapidly progressive myonecrosis, bacteremia, and central nervous system infection. It has been reported as a complication of hemolytic uremic syndrome (HUS) in 8 children worldwide; 5 children died, and the 3 reported survivors had surgically treated disease. We present 3 cases of complicating HUS in children, including the first 2 reported cases of survival without surgical intervention. All patients presented with classic cases of HUS with initial clinical improvement followed by deterioration. Patient 1 had rising fever, tachycardia, and severe abdominal pain 24 hours after admission. She developed large multifocal intraparenchymal cerebral hemorrhages and died 12 hours later. Autopsy revealed intestinal necrosis, myonecrosis, and encephalitis. Patient 2 had new fever, increasing leukocytosis, and severe abdominal pain on hospital day 4. She was diagnosed with bacteremia and treated with metronidazole, meropenem, and clindamycin. Patient 3 had new fever and increasing leukocytosis on hospital day 3; blood cultures grew , and she was treated with penicillin. Patients 2 and 3 improved rapidly and did not require surgery. is a potential co-infection with It thrives in the anaerobic environment of -damaged intestinal mucosa and translocates to cause systemic infection. Fever, tachycardia, a rising white blood cell count, and abdominal pain out of proportion to examination are key findings for which physicians should be vigilant. Timely evaluation by anaerobic blood culture and early initiation of antibiotics are necessary to prevent fatalities.
[Mh] Termos MeSH primário: Infecções por Clostridium/complicações
Síndrome Hemolítico-Urêmica/complicações
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Antibacterianos/uso terapêutico
Bacteriemia/tratamento farmacológico
Bacteriemia/microbiologia
Criança
Pré-Escolar
Infecções por Clostridium/tratamento farmacológico
Clostridium septicum
Feminino
Febre/tratamento farmacológico
Febre/microbiologia
Seres Humanos
Encefalite Infecciosa/microbiologia
Intestinos/patologia
Leucocitose/tratamento farmacológico
Leucocitose/microbiologia
Necrose/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


  4 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28157623
[Au] Autor:Abir B; Malek M; Ridha M
[Ad] Endereço:Department of Neurology, Military Hospital of Instruction of Tunis, Tunisia. Electronic address: abir.fmt@gmail.com.
[Ti] Título:Toxocariasis of the central nervous system: With report of two cases.
[So] Source:Clin Neurol Neurosurg;154:94-97, 2017 Mar.
[Is] ISSN:1872-6968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Toxocariasis is a parasitic infection caused by the roundworms Toxocara canis or Toxocara cati, mostly due to accidental ingestion of embryonated eggs. Clinical manifestations vary and are classified according to the organs affected. Central nervous system involvement is an unusual complication. Here, we report two cases with neurological manifestations, in which there was cerebrospinal fluid (CSF) eosinophilia with marked blood eosinophilia and a positive serology for Toxocara both in serum and CSF. Improvement of signs and symptoms after specific treatment was observed in the two cases.
[Mh] Termos MeSH primário: Eosinofilia/diagnóstico
Encefalite Infecciosa/diagnóstico
Toxocara/patogenicidade
Toxocaríase/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Animais
Eosinofilia/etiologia
Feminino
Seres Humanos
Encefalite Infecciosa/etiologia
Masculino
Meia-Idade
Toxocaríase/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


  5 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28090819
[Au] Autor:Connolly MP; Goodwin E; Schey C; Zummo J
[Ad] Endereço:a Unit of PharmacoEpidemiology & PharmacoEconomics, Department of Pharmacy , University of Groningen , Groningen , The Netherlands.
[Ti] Título:Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis.
[So] Source:Pathog Glob Health;111(1):31-44, 2017 Feb.
[Is] ISSN:2047-7732
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Toxoplasmic encephalitis (TE) is caused by Toxoplasma gondii infection and can be a life-threatening disease in immunocompromised patients. This study evaluated the rate of relapse associated with pyrimethamine-based maintenance therapy (i.e. secondary prophylaxis) in patients with human immunodeficiency virus (HIV) or AIDs treated prior to and after the common use (i.e. 1996) of highly active antiretroviral therapy (HAART) (pre-HAART and post-HAART, respectively). PubMed, Google Scholar, and Cochrane databases were searched to 6 June 2016 using search terms: pyrimethamine, Daraprim, Fansidar, Metakelfin, Fansimef, 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, encephalitis, cerebral, toxoplasmosis, toxoplasmic, and gondii. Single-arm cohort, retrospective, and randomized studies were included. Twenty-six studies with 1,596 patients were included in the analysis; twenty pre-HAART (n = 1,228) studies and six post-HAART (n = 368) were performed. Pooled proportions test for pyrimethamine-based therapy from pre-HAART studies indicated a relapse rate of 19.2% and 18.9% from the fixed-effects and random-effects models, respectively. The relapse rate in the post-HAART studies was 11.1% (fixed and random effects). Continuous therapy was suggestive of lower incidence of relapse compared with intermittent therapy in the pre-HAART era (range, 18.7 to 17.3% vs. 20.9 to 25.6%, respectively). These findings indicate that the likelihood of relapse associated with pyrimethamine-based therepy in patients with HIV and TE decreased after the introduction of HAART to approximately 11%. The findings have important implications as relapse may affect a patient's disease severity and prognosis, increase utilization of health care resources, and result in additional health care expenditure.
[Mh] Termos MeSH primário: Infecções Oportunistas Relacionadas com a AIDS/prevenção & controle
Antiprotozoários/uso terapêutico
Encefalite Infecciosa/prevenção & controle
Pirimetamina/uso terapêutico
Toxoplasmose Cerebral/prevenção & controle
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/uso terapêutico
Terapia Antirretroviral de Alta Atividade
Seres Humanos
Recidiva
Prevenção Secundária/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antiprotozoal Agents); Z3614QOX8W (Pyrimethamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1080/20477724.2016.1273597


  6 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28011613
[Au] Autor:Panackal AA; Komori M; Kosa P; Khan O; Hammoud DA; Rosen LB; Browne SK; Lin YC; Romm E; Ramaprasad C; Fries BC; Bennett JE; Bielekova B; Williamson PR
[Ad] Endereço:Laboratory of Clinical Infectious Diseases (LCID), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda,Maryland; anil.panackal@nih.gov.
[Ti] Título:Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults.
[So] Source:Clin Infect Dis;64(3):275-283, 2017 Feb 01.
[Is] ISSN:1537-6591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cryptococcus can cause meningoencephalitis (CM) among previously healthy non-HIV adults. Spinal arachnoiditis is under-recognized, since diagnosis is difficult with concomitant central nervous system (CNS) pathology. METHODS: We describe 6 cases of spinal arachnoiditis among 26 consecutively recruited CM patients with normal CD4 counts who achieved microbiologic control. We performed detailed neurological exams, cerebrospinal fluid (CSF) immunophenotyping and biomarker analysis before and after adjunctive immunomodulatory intervention with high dose pulse corticosteroids, affording causal inference into pathophysiology. RESULTS: All 6 exhibited severe lower motor neuron involvement in addition to cognitive changes and gait disturbances from meningoencephalitis. Spinal involvement was associated with asymmetric weakness and urinary retention. Diagnostic specificity was improved by MRI imaging which demonstrated lumbar spinal nerve root enhancement and clumping or lesions. Despite negative fungal cultures, CSF inflammatory biomarkers, sCD27 and sCD21, as well as the neuronal damage biomarker, neurofilament light chain (NFL), were elevated compared to healthy donor (HD) controls. Elevations in these biomarkers were associated with clinical symptoms and showed improvement with adjunctive high dose pulse corticosteroids. CONCLUSIONS: These data suggest that a post-infectious spinal arachnoiditis is an important complication of CM in previously healthy individuals, requiring heightened clinician awareness. Despite microbiological control, this syndrome causes significant pathology likely due to increased inflammation and may be amenable to suppressive therapeutics.
[Mh] Termos MeSH primário: Aracnoidite/congênito
Cryptococcus
Encefalite Infecciosa/complicações
Meningite Criptocócica/complicações
Meningoencefalite/complicações
[Mh] Termos MeSH secundário: Adulto
Anti-Inflamatórios/uso terapêutico
Aracnoidite/diagnóstico por imagem
Aracnoidite/tratamento farmacológico
Aracnoidite/imunologia
Aracnoidite/microbiologia
Biomarcadores/líquido cefalorraquidiano
Relação CD4-CD8
Feminino
Seres Humanos
Imunossupressores/uso terapêutico
Encefalite Infecciosa/líquido cefalorraquidiano
Encefalite Infecciosa/tratamento farmacológico
Encefalite Infecciosa/imunologia
Angiografia por Ressonância Magnética
Masculino
Meningite Criptocócica/tratamento farmacológico
Meningite Criptocócica/imunologia
Meningoencefalite/líquido cefalorraquidiano
Meningoencefalite/tratamento farmacológico
Meningoencefalite/imunologia
Metotrexato/uso terapêutico
Metilprednisolona/uso terapêutico
Meia-Idade
Exame Neurológico
Pulsoterapia
Tacrolimo/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biomarkers); 0 (Immunosuppressive Agents); WM0HAQ4WNM (Tacrolimus); X4W7ZR7023 (Methylprednisolone); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161225
[St] Status:MEDLINE
[do] DOI:10.1093/cid/ciw739


  7 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27924792
[Au] Autor:Misra UK; Mani VE; Kalita J
[Ad] Endereço:Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
[Ti] Título:A Cost-Effective Approach to the Diagnosis and Management of Acute Infectious Encephalitis.
[So] Source:Eur Neurol;77(1-2):66-74, 2017.
[Is] ISSN:1421-9913
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:SETTING: A tertiary care teaching hospital in India. OBJECTIVE: To report a syndromic approach to acute encephalitis syndrome (AES) and propose a cost-effective model. STUDY DESIGN: AES patients were categorized by the presence or absence of myalgia/rash into systemic and neurological AES. The patients with systemic AES were investigated for dengue, scrub typhus, leptospira, chikungunya, and malaria, and those with neurological AES were investigated for herpes and Japanese encephalitis (JE). Sensitivity and specificity of syndromic categorization were tested, and cost effectiveness was calculated. RESULTS: There were 210 patients with infectious AES; neurological in 45 and systemic in 165. Specific etiology could be found in 130 (62%) patients, and after excluding 36 patients with co-infections, 94 patients were tested for sensitivity and specificity. Twenty patients had neurological AES (herpes 12, JE 8), and 74 systemic (scrub typhus 42, dengue 20, malaria 6, leptospira 6). The absence of myalgia/rash categorized neurological AES with 100% specificity. In neurological AES, thalamic involvement predicted JE with 100% specificity. In systemic AES, differentiation could not be made between etiologies based on hypotension, thrombocytopenia, and muscle, liver, and kidney dysfunction. In these patients, MRI and acyclovir therapy were warranted, saving cost. By targeted investigations and treatment, the cost was reduced by 70%. CONCLUSIONS: A syndromic approach to AES and goal-directed investigations and treatment substantially reduces the cost of management.
[Mh] Termos MeSH primário: Encefalite Infecciosa/diagnóstico
Encefalite Infecciosa/economia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Índia
Encefalite Infecciosa/classificação
Imagem por Ressonância Magnética
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1159/000453662


  8 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27888402
[Au] Autor:López-Sánchez C; Sulleiro E; Bocanegra C; Romero S; Codina G; Sanz I; Esperalba J; Serra J; Pigrau C; Burgos J; Almirante B; Falcó V
[Ad] Endereço:Infectious Diseases Department, University Hospital Vall d'Hebron, Universidad Autónoma de Barcelona, Paseo de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain.
[Ti] Título:Infectious encephalitis: utility of a rational approach to aetiological diagnosis in daily clinical practice.
[So] Source:Eur J Clin Microbiol Infect Dis;36(4):641-648, 2017 Apr.
[Is] ISSN:1435-4373
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study we attempt to assess the utility of a simplified step-wise diagnostic algorithm to determinate the aetiology of encephalitis in daily clinical practice and to describe the main causes in our setting. This was a prospective cohort study of all consecutive cases of encephalitis in adult patients diagnosed between January 2010 and March 2015 at the University Hospital Vall d'Hebron in Barcelona, Spain. The aetiological study was carried out following the proposed step-wise algorithm. The proportion of aetiological diagnoses achieved in each step was analysed. Data from 97 patients with encephalitis were assessed. Following a simplified step-wise algorithm, a definite diagnosis was made in the first step in 53 patients (55 %) and in 12 additional cases (12 %) in the second step. Overall, a definite or probable aetiological diagnosis was achieved in 78 % of the cases. Herpes virus, L. monocytogenes and M. tuberculosis were the leading causative agents demonstrated, whereas less frequent aetiologies were observed, mainly in immunosuppressed patients. The overall related mortality was 13.4 %. According to our experience, the leading and treatable causes of encephalitis can be identified in a first diagnostic step with limited microbiological studies. L. monocytogenes treatment should be considered on arrival in some patients. Additional diagnostic effort should be made in immunosuppressed patients.
[Mh] Termos MeSH primário: Algoritmos
Técnicas de Laboratório Clínico/métodos
Testes Diagnósticos de Rotina/métodos
Encefalite Infecciosa/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Hospitais Universitários
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Espanha
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE
[do] DOI:10.1007/s10096-016-2840-4


  9 / 63 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27885885
[Au] Autor:Tauber SC; Eiffert H; Brück W; Nau R
[Ad] Endereço:a Department of Neurology , RWTH University Hospital , Aachen , Germany.
[Ti] Título:Septic encephalopathy and septic encephalitis‬‬.
[So] Source:Expert Rev Anti Infect Ther;15(2):121-132, 2017 Feb.
[Is] ISSN:1744-8336
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: During the last two decades, septic encephalopathy (SE) was recognized as a clinically relevant problem with a high prevalence in patients at admission and during their hospital stay. SE is a condition associated with increased mortality and morbidity such as long-term cognitive impairment. Areas covered: This review illustrates the pathophysiology of sepsis-associated encephalopathy and encephalitis involving blood-brain-barrier dysfunction and neuroinflammation caused by endothelial and microglial activation by endogenous or pathogen-derived compounds, hypoxia by impaired microvascular regulation and septic shock as well as imbalance of neurotransmitters. The continuum between septic-embolic and septic-metastatic encephalitis and SE is underlined by histological findings. The options of technical examinations and biomarkers to diagnose SE are discussed together with established therapeutic options as well as current experimental approaches. Expert commentary: An outlook for clinicians is provided including promising diagnostic approaches by means of new imaging techniques. Clinical trials with drugs already established for other indications such as statins, erythropoietin and minocycline are warranted in the future.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/fisiopatologia
Encefalopatias/etiologia
Encefalite Infecciosa/etiologia
Sepse/complicações
[Mh] Termos MeSH secundário: Biomarcadores/análise
Barreira Hematoencefálica/diagnóstico por imagem
Barreira Hematoencefálica/imunologia
Encefalopatias/diagnóstico por imagem
Encefalopatias/mortalidade
Encefalopatias/prevenção & controle
Citocinas/imunologia
Homeostase
Seres Humanos
Encefalite Infecciosa/diagnóstico por imagem
Encefalite Infecciosa/mortalidade
Encefalite Infecciosa/prevenção & controle
Neurotransmissores/metabolismo
Sepse/diagnóstico por imagem
Sepse/mortalidade
Sepse/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cytokines); 0 (Neurotransmitter Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1080/14787210.2017.1265448


  10 / 63 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27613638
[Au] Autor:Hamamoto Filho PT; Fabro AT; Rodrigues MV; Bazan R; Vulcano LC; Biondi GF; Zanini MA
[Ad] Endereço:Department of Neurology, Psychology and Psychiatry; Botucatu Medical School, UNESP - Univ. Estadual Paulista, Botucatu, SP, Brazil. pthamamotof@hotmail.com.
[Ti] Título:Taenia crassiceps injection into the subarachnoid space of rats simulates radiological and morphological features of racemose neurocysticercosis.
[So] Source:Childs Nerv Syst;33(1):119-123, 2017 Jan.
[Is] ISSN:1433-0350
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Neurocysticercosis is a major public health concern. Although its eradication appears feasible, the disease remains endemic in developing countries and has emerged again in Europe and in the USA. Basic studies on neurocysticercosis are needed to better understand the pathophysiologic mechanisms and, consequently, to improve treatment perspectives. Much has been published on experimental parenchymal neurocysticercosis, but there are no experimental models of racemose neurocysticercosis. METHODS: Cysts of Taenia crassiceps were injected into the subarachnoid space of 11 rats. After 4 months, magnetic resonance imaging (MRI) was performed to verify the occurrence of ventricular dilatation and the distribution of cysts in the cerebrospinal fluid compartments. The histologic assessment was done focusing on changes in the ependyma, choroid plexus, and brain parenchyma. RESULTS: MRI and histologic assessment confirmed the findings similar to those seen in human racemose neurocysticercosis including enlargement of the basal cisterns, hydrocephalus, and inflammatory infiltration through the ependyma and choroid plexus into cerebrospinal fluid spaces. CONCLUSIONS: We developed a simple model of racemose neurocysticercosis by injecting cysts of T. crassiceps into the subarachnoid space of rats. This model can help understand the pathophysiologic mechanisms of the disease.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Encefalite Infecciosa
Neurocisticercose
[Mh] Termos MeSH secundário: Animais
Ratos
Ratos Wistar
Espaço Subaracnóideo/patologia
Taenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE
[do] DOI:10.1007/s00381-016-3239-3



página 1 de 7 ir para página                  
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde