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[PMID]:29443669
[Au] Autor:El-Jawahri AR; Schaefer PW; El Khoury JB; Martinez-Lage M
[Ad] Endereço:From the Departments of Medicine (A.R.E.-J., J.B.E.K.), Radiology (P.W.S.), and Pathology (M.M.-L.), Massachusetts General Hospital, and the Departments of Medicine (A.R.E.-J., J.B.E.K.), Radiology (P.W.S.), and Pathology (M.M.-L.), Harvard Medical School - both in Boston.
[Ti] Título:Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation.
[So] Source:N Engl J Med;378(7):659-669, 2018 Feb 15.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Confusão/etiologia
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Herpesvirus Humano 6/isolamento & purificação
Hospedeiro Imunocomprometido
Meningoencefalite/diagnóstico
Infecções por Roseolovirus/diagnóstico
[Mh] Termos MeSH secundário: Antivirais/uso terapêutico
Autopsia
Diagnóstico Diferencial
Evolução Fatal
Foscarnet/uso terapêutico
Reação Enxerto-Hospedeiro
Seres Humanos
Leucemia Linfocítica Crônica de Células B/terapia
Masculino
Meningoencefalite/complicações
Meningoencefalite/virologia
Meia-Idade
Infecções por Roseolovirus/complicações
Infecções por Roseolovirus/tratamento farmacológico
Transplante Homólogo
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 364P9RVW4X (Foscarnet)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1707556


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[PMID]:28742087
[Au] Autor:Soong L; Shelite TR; Xing Y; Kodakandla H; Liang Y; Trent BJ; Horton P; Smith KC; Zhao Z; Sun J; Bouyer DH; Cai J
[Ad] Endereço:Department of Microbiology and Immunology, Institute of Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America.
[Ti] Título:Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice.
[So] Source:PLoS Negl Trop Dis;11(7):e0005765, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Scrub typhus is a life-threatening disease, due to infection with O. tsutsugamushi, a Gram-negative bacterium that preferentially replicates in endothelial cells and professional phagocytes. Meningoencephalitis has been reported in scrub typhus patients and experimentally-infected animals; however, the neurological manifestation and its underlying mechanisms remain poorly understood. To address this issue, we focused on Orientia tsutsugamushi Karp strain (OtK), and examined host responses in the brain during lethal versus self-healing scrub typhus disease in our newly established murine models. PRINCIPLE FINDINGS: Following inoculation with a lethal dose of OtK, mice had a significant increase in brain transcripts related to pathogen-pattern recognition receptors (TLR2, TLR4, TLR9), type-1 responses (IFN-γ, TNF-α, CXCL9, CXCR3), and endothelial stress/damage such as angiopoietins, but a rapid down-regulation of Tie2. Sublethal infection displayed similar trends, implying the development of type 1-skewed proinflammatory responses in infected brains, independent of time and disease outcomes. Focal hemorrhagic lesions and meningitis were evident in both infection groups, but pathological changes were more diffuse and frequent in lethal infection. At 6-10 days of lethal infection, the cortex and cerebellum sections had increased ICAM-1-positive staining in vascular cells, as well as increased detection of CD45+ leukocytes, CD3+ T cells, IBA1+ phagocytes, and GFAP+ astrocytes, but a marked loss of occludin-positive tight junction staining, implying progressive endothelial activation/damage and cellular recruitment in inflamed brains. Orientia were sparse in the brains, but readily detectable within lectin+ vascular and IBA-1+ phagocytic cells. These CNS alterations were consistent with type 1-skewed, IL-13-suppressed responses in lethally-infected mouse lungs. SIGNIFICANCE: This is the first report of type 1-skewed neuroinflammation and cellular activation, accompanied with vascular activation/damage, during OtK infection in C57BL/6 mice. This study not only enhances our understanding of the pathophysiological mechanisms of scrub typhus, but also correlates the impact of immune and vascular dysfunction on disease pathogenesis.
[Mh] Termos MeSH primário: Encéfalo/patologia
Meningoencefalite/fisiopatologia
Tifo por Ácaros/complicações
Tifo por Ácaros/patologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/imunologia
Citocinas/análise
Modelos Animais de Doenças
Regulação para Baixo
Feminino
Seres Humanos
Inflamação
Pulmão/patologia
Meningoencefalite/microbiologia
Camundongos
Camundongos Endogâmicos C57BL
Orientia tsutsugamushi
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180120
[Lr] Data última revisão:
180120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005765


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[PMID]:28904730
[Au] Autor:Mouhadi K; Boulahri T; Rouimi A
[Ad] Endereço:Faculté de Médecine et de Pharmacie, Marrakech, Maroc.
[Ti] Título:[Tuberculous meningoencephalitis revealed by psychiatric disorders: about a case].
[Ti] Título:Méningo-encéphalite tuberculeuse révélée par des troubles psychiatriques: à propos d'un cas..
[So] Source:Pan Afr Med J;27:206, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Tuberculous meningoencephalitis is fairly frequent in endemic countries and it is the most severe form of tuberculosis. Therapeutic failure is common because of diagnostic delay. This delay is primarily due to a wide clinical polymorphism and, in particular, to misleading forms. We here report a rare clinical case of tuberculous meningitis in a patient in prodromal phase of psychosis.
[Mh] Termos MeSH primário: Meningoencefalite/diagnóstico
Transtornos Mentais/diagnóstico
Tuberculose Meníngea/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Tardio
Seres Humanos
Masculino
Meningoencefalite/psicologia
Transtornos Mentais/microbiologia
Tuberculose Meníngea/psicologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.206.12811


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[PMID]:28829736
[Au] Autor:Pradhan F; Burns JD; Agameya A; Patel A; Alfaqih M; Small JE; Ooi W
[Ad] Endereço:Department of Internal Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts.
[Ti] Título:Case Report: Zika Virus Meningoencephalitis and Myelitis and Associated Magnetic Resonance Imaging Findings.
[So] Source:Am J Trop Med Hyg;97(2):340-343, 2017 Aug.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zika virus (ZIKV) has a wide clinical spectrum of associated neurologic disease including microcephaly and Guillain-Barre syndrome but, despite its known neurotropism, ZIKV meningoencephalitis and myelitis have been rare complications. We describe a case of ZIKV meningoencephalitis and probable myelitis and its associated magnetic resonance imaging findings that rapidly resolved during recovery in a previously healthy adult.
[Mh] Termos MeSH primário: Meningoencefalite/diagnóstico
Meningoencefalite/etiologia
Mielite/diagnóstico
Mielite/etiologia
Infecção pelo Zika virus/complicações
Infecção pelo Zika virus/diagnóstico
Zika virus/isolamento & purificação
[Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem
Encéfalo/virologia
Seres Humanos
Imagem por Ressonância Magnética
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0921


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[PMID]:28804111
[Au] Autor:Shimozono K; Hayashi Y; Nishinaka T; Kobayashi S
[Ad] Endereço:Department of Internal Medicine, Otemachi Hospital.
[Ti] Título:An adult case of group A streptococcus meningitis associated with steroid-responsive meningoencephalitis.
[So] Source:Rinsho Shinkeigaku;57(9):499-503, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A previously healthy 80-year-old woman presented to our service in a comatose state. On examination the patient had fever and neck stiffness. Laboratory investigation showed polymorphonuclear pleocytosis in cerebro-spinal fluid (CSF). These findings prompted us to a diagnosis of bacterial or viral meningitis and combination therapy consisting of ceftriaxone, vancomycin and acyclovir was started immediately. Two days later, culture of blood yielded Streptococcus pyogenes (group A streptococcus; GAS). The antibiotic therapy was converted to intravenous ampicillin for 14 days. Fever resolved quickly, however, somnolence persisted. Fluid attenuated inversion recovery image of the brain, taken on the day 29, showed focal hyperintense lesions on the right subcortical area in the temporal and parietal lobes. Three times repeated intravenous steroid pulse therapy (methylprednisolone 1,000 mg/day, 3 days) resulted in complete improvement of her consciousness disturbance. We considered the present case to be a steroid-responsive meningoencephalitis caused by GAS infection.
[Mh] Termos MeSH primário: Ampicilina/administração & dosagem
Antibacterianos/administração & dosagem
Meningites Bacterianas/complicações
Meningites Bacterianas/tratamento farmacológico
Meningoencefalite/complicações
Meningoencefalite/tratamento farmacológico
Metilprednisolona/administração & dosagem
Infecções Estreptocócicas/complicações
Infecções Estreptocócicas/tratamento farmacológico
Streptococcus pyogenes/isolamento & purificação
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Esquema de Medicação
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Meningites Bacterianas/diagnóstico por imagem
Meningoencefalite/diagnóstico por imagem
Pulsoterapia
Infecções Estreptocócicas/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 7C782967RD (Ampicillin); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001022


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[PMID]:28722617
[Au] Autor:Brulliard C; Traversier N; Allyn J; Schaeffer C; Bouchet B; Allou N
[Ad] Endereço:Réanimation Polyvalente, Centre Hospitalier Universitaire Félix Guyon, Saint Denis, France.
[Ti] Título:Case Report: Disseminated Infection with Meningoencephalitis in a Traveler Secondary to Marine Injury in Madagascar.
[So] Source:Am J Trop Med Hyg;97(4):1043-1044, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Marine microorganisms such as spp., spp., and spp. can cause sepsis secondary to a wound infection in the context of swimming. These microorganisms are most often susceptible to fluoroquinolones. Here, we report a unique case of bacteremia associated with meningoencephalitis and disseminated via hematogenous spread secondary to a skin injury. The patient suffered the injury while swimming in saline water during a cruise holiday in Madagascar, and she was initially treated with amoxicillin. The neurological evolution was unsatisfactory. Better knowledge of such infections (and especially of the context in which they occur), as well as greater familiarity with the susceptibility profile of different marine microorganisms would have allowed health professionals to provide presumptive microbiological diagnosis and effective treatment earlier.
[Mh] Termos MeSH primário: Amoxicilina/uso terapêutico
Antibacterianos/uso terapêutico
Infecções por Bactérias Gram-Negativas/complicações
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Meningoencefalite/tratamento farmacológico
Meningoencefalite/etiologia
Ferimentos e Lesões/complicações
[Mh] Termos MeSH secundário: Adulto
Animais
Feminino
Infecções por Bactérias Gram-Negativas/diagnóstico
Seres Humanos
Madagáscar
Meningoencefalite/diagnóstico
Água do Mar/microbiologia
Sepse/tratamento farmacológico
Sepse/etiologia
Shewanella/efeitos dos fármacos
Natação
Viagem
Resultado do Tratamento
Infecção dos Ferimentos/tratamento farmacológico
Infecção dos Ferimentos/etiologia
Ferimentos e Lesões/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 804826J2HU (Amoxicillin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.17-0175


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Martelli, Celina Maria Turchi
Texto completo SciELO Brasil
[PMID]:28700057
[Au] Autor:Tassara MP; Guilarde AO; Rocha BAMD; Féres VCR; Martelli CMT
[Ad] Endereço:Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
[Ti] Título:Neurological manifestations of dengue in Central Brazil.
[So] Source:Rev Soc Bras Med Trop;50(3):379-382, 2017 May-Jun.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: : The incidence of dengue has increased throughout the 2000s with a consequent global increase in atypical clinical forms. METHODS: : This study reports a series of cases of neurological dengue out of 498 confirmed cases of laboratory dengue in Goiânia, Brazil. Cases were confirmed based on viral RNA detection via polymerase chain reaction or IgM antibody capture. RESULTS: : Neurological symptoms occurred in 5.6% of cases, including paresthesia (3.8%), encephalitis (2%), encephalopathy (1%), seizure (0.8%), meningoencephalitis (0.4%), and paresis (0.4%). DENV-3 was the predominant circulating serotype (93%). CONCLUSIONS: : We reported dengue cases with neurological manifestations in endemic area.
[Mh] Termos MeSH primário: Dengue/complicações
Encefalite Viral/virologia
Meningoencefalite/virologia
Parestesia/virologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Anticorpos Antivirais/sangue
Brasil/epidemiologia
Pré-Escolar
Dengue/epidemiologia
Vírus da Dengue/genética
Vírus da Dengue/imunologia
Encefalite Viral/epidemiologia
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Masculino
Meningoencefalite/epidemiologia
Meia-Idade
Parestesia/epidemiologia
Reação em Cadeia da Polimerase
RNA Viral/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (RNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28628941
[Au] Autor:Wilson MR; Suan D; Duggins A; Schubert RD; Khan LM; Sample HA; Zorn KC; Rodrigues Hoffman A; Blick A; Shingde M; DeRisi JL
[Ad] Endereço:Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA.
[Ti] Título:A novel cause of chronic viral meningoencephalitis: Cache Valley virus.
[So] Source:Ann Neurol;82(1):105-114, 2017 Jul.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Immunodeficient patients are particularly vulnerable to neuroinvasive infections that can be challenging to diagnose. Metagenomic next generation sequencing can identify unusual or novel microbes and is therefore well suited for investigating the etiology of chronic meningoencephalitis in immunodeficient patients. METHODS: We present the case of a 34-year-old man with X-linked agammaglobulinemia from Australia suffering from 3 years of meningoencephalitis that defied an etiologic diagnosis despite extensive conventional testing, including a brain biopsy. Metagenomic next generation sequencing of his cerebrospinal fluid and brain biopsy tissue was performed to identify a causative pathogen. RESULTS: Sequences aligning to multiple Cache Valley virus genes were identified via metagenomic next generation sequencing. Reverse transcription polymerase chain reaction and immunohistochemistry subsequently confirmed the presence of Cache Valley virus in the brain biopsy tissue. INTERPRETATION: Cache Valley virus, a mosquito-borne orthobunyavirus, has only been identified in 3 immunocompetent North American patients with acute neuroinvasive disease. The reported severity ranges from a self-limiting meningitis to a rapidly fatal meningoencephalitis with multiorgan failure. The virus has never been known to cause a chronic systemic or neurologic infection in humans. Cache Valley virus has also never previously been detected on the Australian continent. Our research subject traveled to North and South Carolina and Michigan in the weeks prior to the onset of his illness. This report demonstrates that metagenomic next generation sequencing allows for unbiased pathogen identification, the early detection of emerging viruses as they spread to new locales, and the discovery of novel disease phenotypes. Ann Neurol 2017;82:105-114.
[Mh] Termos MeSH primário: Encéfalo/virologia
Vírus Bunyamwera/patogenicidade
Encefalite Viral/virologia
Meningoencefalite/virologia
[Mh] Termos MeSH secundário: Adulto
Vírus Bunyamwera/genética
Encefalite Viral/líquido cefalorraquidiano
Seres Humanos
Masculino
Meningoencefalite/líquido cefalorraquidiano
Metagenômica
Análise de Sequência de DNA
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24982


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[PMID]:28438128
[Au] Autor:Lohitharajah J; Malavige N; Arambepola C; Wanigasinghe J; Gamage R; Gunaratne P; Ratnayake P; Chang T
[Ad] Endereço:Department of Pathophysiology, Eastern University, Colombo, Sri Lanka.
[Ti] Título:Viral aetiologies of acute encephalitis in a hospital-based South Asian population.
[So] Source:BMC Infect Dis;17(1):303, 2017 Apr 24.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population. METHODS: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Cerebrospinal fluid and serum were tested for conventional and emerging encephalitogenic viruses. Specific nucleic acid amplification and antibody assays were used to identify viruses. Plaque reduction neutralization test was done to confirm the diagnosis of West Nile virus (WNV). RESULTS: Patients' age ranged from 1 month to 73 years (mean = 24.91; SD = 21.33) with a male:female ratio of 1.75:1. A viral aetiology was identified in only 27.3%. These included dengue virus (40.7%), Japanese encephalitis virus (25.9%), varicella zoster virus, WNV and probable Epstein Barr virus (11.1% each). None were positive for herpes simplex viruses or cytomegalovirus. Screening for bacterial aetiologies was negative for all patients. There were no distinguishable clinical or laboratory findings between the different viral aetiologies. The case fatality rate was 7%, which was higher among patients with an identified viral aetiology. CONCLUSIONS: A viral aetiology was identified in only about a quarter of patients with encephalitis. Dengue virus accounted for the majority.
[Mh] Termos MeSH primário: Anticorpos Antivirais/sangue
Vírus da Dengue/imunologia
Vírus da Encefalite Japonesa (Espécie)/imunologia
Encefalite Viral/virologia
Herpesvirus Humano 3/imunologia
Meningoencefalite/virologia
Vírus do Nilo Ocidental/imunologia
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Estudos Transversais
Vírus da Dengue/isolamento & purificação
Vírus da Encefalite Japonesa (Espécie)/isolamento & purificação
Encefalite Viral/imunologia
Feminino
Herpesvirus Humano 3/isolamento & purificação
Seres Humanos
Lactente
Masculino
Meningoencefalite/imunologia
Meia-Idade
Sri Lanka/epidemiologia
Vírus do Nilo Ocidental/isolamento & purificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2403-z


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[PMID]:28267222
[Au] Autor:Cornelis I; Volk HA; Van Ham L; De Decker S
[Ad] Endereço:Clinical Science and Services, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL97TA, UK.
[Ti] Título:Clinical presentation, diagnostic findings and outcome in dogs diagnosed withpresumptive spinal-only meningoen-cephalomyelitis of unknown origin.
[So] Source:J Small Anim Pract;58(3):174-182, 2017 Mar.
[Is] ISSN:1748-5827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone. METHODS: Medical records were reviewed for dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin between 2006 and 2015. RESULTS: 21 dogs were included; the majority presented with an acute (43%) or chronic (52%) onset of neurological signs. Ambulatory paresis was the most common neurological presentation (67%). Neurological examination most commonly revealed a T3-L3 myelopathy, and spinal hyperaesthesia was a common finding (71%). A spinal cord lesion was visible in 90% of cases on magnetic resonance imaging. Eighteen lesions (86%) showed parenchymal contrast enhancement and 17 lesions (81%) showed contrast enhancement of overlying meninges. All dogs were treated with immunosuppressive doses of glucocorticosteroids, sometimes combined with cytosine arabinoside. At time of data capture, 10/21 dogs (48%) had died or been euthanased because of the condition. Overall median survival time was 669 days. CLINICAL SIGNIFICANCE: Meningoencephalomyelitis of unknown origin should be considered in the differential diagnosis of dogs presenting with a progressive myelopathy. Magnetic resonance imaging features can possibly help to distinguish presumptive meningoencephalomyelitis of unknown origin from other more common spinal diseases. Overall, long-term survival is guarded, approximately 50% of dogs will die or be euthanased despite appropriate therapy.
[Mh] Termos MeSH primário: Doenças do Cão/diagnóstico
Encefalomielite/veterinária
Meningoencefalite/veterinária
Doenças da Medula Espinal/veterinária
Medula Espinal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Animais
Citarabina/uso terapêutico
Doenças do Cão/tratamento farmacológico
Cães
Encefalomielite/diagnóstico
Encefalomielite/tratamento farmacológico
Feminino
Glucocorticoides/uso terapêutico
Imunossupressores/uso terapêutico
Imagem por Ressonância Magnética/veterinária
Masculino
Meningoencefalite/diagnóstico
Meningoencefalite/tratamento farmacológico
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Immunosuppressive Agents); 04079A1RDZ (Cytarabine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1111/jsap.12622



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