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[PMID]:28760912
[Au] Autor:Parrino L; Pavesi G
[Ad] Endereço:From the Sleep Disorders Center (L.P.) and Unit of Neurology (G.P.), Azienda Ospedaliero-Universitaria di Parma, Italy. liborio.parrino@unipr.it.
[Ti] Título:When sleep-related hypermotor epilepsy (SHE) met Charles Darwin and Francis Galton.
[So] Source:Neurology;89(5):502-505, 2017 Aug 01.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep-related hypermotor epilepsy (SHE) is characterized by short-lasting seizures patterned by repetitive and stereotyped motor events in the same person. In autosomal dominant SHE, genetic factors play a well-known key role. In Charles Darwin quotes a plausible example of SHE illustrated by his cousin Sir Francis Galton: "the gentleman…lay fast asleep on his back in bed, raising his right arm slowly in front of his face, up to his forehead, and then dropping it with a jerk, so that the wrist fell heavily on the bridge of his nose. The trick did not occur every night, but occasionally, and was independent of any ascertained cause. Sometimes it was repeated incessantly for an hour or more." Similar manifestations during sleep occurred also in the patient's son and granddaughter, suggesting an autosomal inheritance without sex relationship. Differential diagnosis with REM behavior disorder and other parasomnias is discussed. To our knowledge, this could be the first description of a stereotyped SHE pattern with genetic transmission.
[Mh] Termos MeSH primário: Epilepsia Motora Parcial/história
Transtornos do Sono-Vigília/história
[Mh] Termos MeSH secundário: Livros/história
Epilepsia Motora Parcial/genética
Predisposição Genética para Doença
História do Século XIX
História do Século XX
Seres Humanos
Transtornos do Sono-Vigília/genética
Reino Unido
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Darwin C; Galton F
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004134


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[PMID]:28502693
[Au] Autor:Morris SA; Rollo M; Rollo P; Johnson J; Grant GA; Friedman E; Kalamangalam G; Tandon N
[Ad] Endereço:Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
[Ti] Título:Prolonged Blood-Brain Barrier Disruption Following Laser Interstitial Ablation in Epilepsy: A Case Series with a Case Report of Postablation Optic Neuritis.
[So] Source:World Neurosurg;104:467-475, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Laser interstitial thermal therapy has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in >1000 patients, the long-term effects of photothermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed clinical and radiographic courses of 13 patients undergoing laser ablation for focal epilepsy by the senior author (N.T.). Only patients with nonenhancing lesions and patients who had a delayed postoperative magnetic resonance imaging (MRI) scan with gadolinium administration approximately 6 months after ablation were considered. Volumetric estimates of the amount of enhancement immediately after ablation and on the delayed MRI scan were made. RESULTS: Median interval between surgery and delayed postoperative MRI scan was 6 months (range, 5-8 months). In 12 of 13 cases, persistent enhancement was seen, consistent with prolonged blood-brain barrier dysfunction. Enhancement, when present, was 9%-67% (mean 30%). There was no correlation between the time from surgery and the relative percentage of postoperative enhancement on MRI. The blood-brain barrier remained compromised to gadolinium contrast for up to 8 months after thermal therapy. There were no adverse events from surgical intervention; however, 1 patient developed delayed optic neuritis. CONCLUSIONS: Prolonged incompetence of the blood-brain barrier produced by thermal ablation may provide a path for delivery of macromolecules into perilesional tissue, which could be exploited for therapeutic benefit, but rarely it may result in autoimmune central nervous system inflammatory conditions.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/fisiologia
Epilepsia Resistente a Medicamentos/fisiopatologia
Epilepsia Resistente a Medicamentos/cirurgia
Epilepsias Parciais/fisiopatologia
Epilepsias Parciais/cirurgia
Epilepsia Parcial Complexa/fisiopatologia
Epilepsia Parcial Complexa/cirurgia
Epilepsia Motora Parcial/fisiopatologia
Epilepsia Motora Parcial/cirurgia
Epilepsia do Lobo Temporal/fisiopatologia
Epilepsia do Lobo Temporal/cirurgia
Hemianopsia/diagnóstico
Hemianopsia/fisiopatologia
Terapia a Laser/métodos
Neurite Óptica/diagnóstico
Neurite Óptica/fisiopatologia
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/fisiopatologia
Técnicas Estereotáxicas
Cirurgia Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Coortes
Angiografia por Tomografia Computadorizada
Meios de Contraste
Feminino
Gadolínio
Seres Humanos
Interpretação de Imagem Assistida por Computador
Terapia a Laser/instrumentação
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Estudos Prospectivos
Cirurgia Assistida por Computador/instrumentação
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


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[PMID]:28387951
[Au] Autor:Jobst BC; Kapur R; Barkley GL; Bazil CW; Berg MJ; Bergey GK; Boggs JG; Cash SS; Cole AJ; Duchowny MS; Duckrow RB; Edwards JC; Eisenschenk S; Fessler AJ; Fountain NB; Geller EB; Goldman AM; Goodman RR; Gross RE; Gwinn RP; Heck C; Herekar AA; Hirsch LJ; King-Stephens D; Labar DR; Marsh WR; Meador KJ; Miller I; Mizrahi EM; Murro AM; Nair DR; Noe KH; Olejniczak PW; Park YD; Rutecki P; Salanova V; Sheth RD; Skidmore C; Smith MC; Spencer DC; Srinivasan S; Tatum W; Van Ness P; Vossler DG; Wharen RE; Worrell GA; Yoshor D; Zimmerman RS; Skarpaas TL; Morrell MJ
[Ad] Endereço:Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, U.S.A.
[Ti] Título:Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas.
[So] Source:Epilepsia;58(6):1005-1014, 2017 Jun.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Evaluate the seizure-reduction response and safety of brain-responsive stimulation in adults with medically intractable partial-onset seizures of neocortical origin. METHODS: Patients with partial seizures of neocortical origin were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline. Safety was assessed based on reported adverse events. Additional analyses considered safety and seizure reduction according to lobe and functional area (e.g., eloquent cortex) of seizure onset. RESULTS: There were 126 patients with seizures of neocortical onset. The average follow-up was 6.1 implant years. The median percent seizure reduction was 70% in patients with frontal and parietal seizure onsets, 58% in those with temporal neocortical onsets, and 51% in those with multilobar onsets (last observation carried forward [LOCF] analysis). Twenty-six percent of patients experienced at least one seizure-free period of 6 months or longer and 14% experienced at least one seizure-free period of 1 year or longer. Patients with lesions on magnetic resonance imaging (MRI; 77% reduction, LOCF) and those with normal MRI findings (45% reduction, LOCF) benefitted, although the treatment response was more robust in patients with an MRI lesion (p = 0.02, generalized estimating equation [GEE]). There were no differences in the seizure reduction in patients with and without prior epilepsy surgery or vagus nerve stimulation. Stimulation parameters used for treatment did not cause acute or chronic neurologic deficits, even in eloquent cortical areas. The rates of infection (0.017 per patient implant year) and perioperative hemorrhage (0.8%) were not greater than with other neurostimulation devices. SIGNIFICANCE: Brain-responsive stimulation represents a safe and effective treatment option for patients with medically intractable epilepsy, including adults with seizures of neocortical onset, and those with onsets from eloquent cortex.
[Mh] Termos MeSH primário: Córtex Cerebral/fisiopatologia
Estimulação Encefálica Profunda/métodos
Epilepsia Resistente a Medicamentos/fisiopatologia
Epilepsia Resistente a Medicamentos/terapia
Terapia por Estimulação Elétrica/métodos
Eletroencefalografia
Neocórtex/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Mapeamento Encefálico
Estimulação Encefálica Profunda/instrumentação
Terapia por Estimulação Elétrica/instrumentação
Eletrodos Implantados
Epilepsias Parciais/fisiopatologia
Epilepsias Parciais/terapia
Epilepsia Parcial Complexa/fisiopatologia
Epilepsia Parcial Complexa/terapia
Epilepsia Motora Parcial/fisiopatologia
Epilepsia Motora Parcial/terapia
Epilepsia Tônico-Clônica/fisiopatologia
Epilepsia Tônico-Clônica/terapia
Estudos de Viabilidade
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13739


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[PMID]:28378422
[Au] Autor:Dugan P; Carlson C; Jetté N; Wiebe S; Bunch M; Kuzniecky R; French J
[Ad] Endereço:Department of Neurology, New York University Langone Medical Center, New York, New York, U.S.A.
[Ti] Título:Derivation and initial validation of a surgical grading scale for the preliminary evaluation of adult patients with drug-resistant focal epilepsy.
[So] Source:Epilepsia;58(5):792-800, 2017 May.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Presently, there is no simple method at initial presentation for identifying a patient's likelihood of progressing to surgery and a favorable outcome. The Epilepsy Surgery Grading Scale (ESGS) is a three-tier empirically derived mathematical scale with five categories: magnetic resonance imaging (MRI), electroencephalography (EEG), concordance (between MRI and EEG), semiology, and IQ designed to stratify patients with drug-resistant focal epilepsy based on their likelihood of proceeding to resective epilepsy surgery and achieving seizure freedom. METHODS: In this cross-sectional study, we abstracted data from the charts of all patients admitted to the New York University Langone Medical Center (NYULMC) for presurgical evaluation or presented in surgical multidisciplinary conference (MDC) at the NYU Comprehensive Epilepsy Center (CEC) from 1/1/2007 to 7/31/2008 with focal epilepsy, who met minimal criteria for treatment resistance. We classified patients into ESGS Grade 1 (most favorable), Grade 2 (intermediate), and Grade 3 (least favorable candidates). Three cohorts were evaluated: all patients, patients presented in MDC, and patients who had resective surgery. The primary outcome measure was proceeding to surgery and seizure freedom. RESULTS: Four hundred seven patients met eligibility criteria; 200 (49.1%) were presented in MDC and 113 (27.8%) underwent surgery. A significant difference was observed between Grades 1 and 3, Grades 1 and 2, and Grades 2 and 3 for all presurgical patients, and those presented in MDC, with Grade 1 patients having the highest likelihood of both having surgery and becoming seizure-free. There was no difference between Grades 1 and 2 among patients who had resective surgery. SIGNIFICANCE: These results demonstrate that by systematically using basic information available during initial assessment, patients with drug-resistant epilepsy may be successfully stratified into clinically meaningful groups with varied prognosis. The ESGS may improve communication, facilitate decision making and early referral to a CEC, and allow patients and physicians to better manage expectations.
[Mh] Termos MeSH primário: Algoritmos
Anticonvulsivantes/uso terapêutico
Epilepsia Resistente a Medicamentos/classificação
Epilepsia Resistente a Medicamentos/cirurgia
Eletroencefalografia
Epilepsia Motora Parcial/classificação
Epilepsia Motora Parcial/cirurgia
Inteligência
Imagem por Ressonância Magnética
Avaliação de Resultados (Cuidados de Saúde)/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Anticonvulsivantes/efeitos adversos
Estudos de Coortes
Epilepsia Resistente a Medicamentos/diagnóstico
Epilepsia Resistente a Medicamentos/tratamento farmacológico
Epilepsia Motora Parcial/diagnóstico
Epilepsia Motora Parcial/tratamento farmacológico
Feminino
Seres Humanos
Funções Verossimilhança
Masculino
Prognóstico
Encaminhamento e Consulta/estatística & dados numéricos
Medição de Risco/estatística & dados numéricos
Lobo Temporal/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13730


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[PMID]:28295226
[Au] Autor:Strzelczyk A; Zöllner JP; Willems LM; Jost J; Paule E; Schubert-Bast S; Rosenow F; Bauer S
[Ad] Endereço:Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University, Frankfurt am Main, Germany.
[Ti] Título:Lacosamide in status epilepticus: Systematic review of current evidence.
[So] Source:Epilepsia;58(6):933-950, 2017 Jun.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The intravenous formulation of lacosamide (LCM) and its good overall tolerability and safety favor the use in status epilepticus (SE). The aim of this systematic review was to identify and evaluate studies reporting on the use of LCM in SE. METHODS: We performed a systematic literature search of electronic databases using a combined search strategy from 2008 until October 2016. Using a standardized assessment form, information on the study design, methodologic framework, data sources, efficacy, and adverse events attributed to LCM were extracted from each publication and systematically reported. RESULTS: In total, 522 SE episodes (51.7% female) in 486 adults and 36 children and adolescents were evaluated with an overall LCM efficacy of 57%. Efficacy was comparable between use in nonconvulsive (57%; 82/145) and generalized-convulsive (61%; 30/49; p = 0.68) SE, whereas overall success rate was better in focal motor SE (92%; 34/39, p = 0.013; p < 0.001). The efficacy with later positioning of LCM decreased from 100% to 20%. The main adverse events during treatment of SE are dizziness, abnormal vision, diplopia, and ataxia. Overall, lacosamide is well tolerated and has no clinically relevant drug-drug interactions. SIGNIFICANCE: The available data regarding the use of LCM in SE are promising, with a success rate of 57%. The strength of LCM is the lack of interaction potential and the option for intravenous use in emergency situations requiring rapid uptitration.
[Mh] Termos MeSH primário: Acetamidas/uso terapêutico
Estado Epiléptico/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetamidas/efeitos adversos
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Epilepsia Motora Parcial/tratamento farmacológico
Feminino
Seres Humanos
Lactente
Recém-Nascido
Infusões Intravenosas
Masculino
Meia-Idade
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Acetamides); 563KS2PQY5 (lacosamide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13716


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[PMID]:27455832
[Au] Autor:Thiarawat P; Wangtheraprasert A; Jitprapaikulsan J
[Ti] Título:Vagoglossopharyngeal Neuralgia Occurred Concomitantly with Ipsilateral Hemifacial Spasm and Versive Seizure-Like Movement: A First Case Report.
[So] Source:J Med Assoc Thai;99(1):106-10, 2016 Jan.
[Is] ISSN:0125-2208
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:Vagoglossopharyngeal neuralgia (VGPN) is a very rare condition. VGPN with convulsive like attack is even rarer All of the cases had their head turned to the opposite side of facial pain. Hemifacial spasm occurring concurrently with VGPN has never been reported. Herein, we present the first case of VGPN that had ipsilateral hemifacial spasm and versive seizure-like movement to the same side of facial pain. We reported a 71-year-old man presenting with multiple episodes of intermittent sharp shooting pain arising on the right middle neck, followed by hemifacial spasm on right face. Then the patient became syncope while his head and gaze turned to the same side of the painful neck. Electrocardiography showed sinus arrest. Interictal Electroencephalography was normal. This patient initially responded to pregabalin for two weeks, then the symptoms became worse. Microvascular decompression and carbamazepine resulted in the complete remission of all symptoms after six months of follow-up. We could not explain the pathophysiology of unilateral versive seizure like movement.
[Mh] Termos MeSH primário: Epilepsia Motora Parcial/complicações
Doenças do Nervo Glossofaríngeo/complicações
Espasmo Hemifacial/complicações
Neuralgia/complicações
Parada Sinusal Cardíaca/complicações
Síncope/complicações
Doenças do Nervo Vago/complicações
[Mh] Termos MeSH secundário: Idoso
Carbamazepina/uso terapêutico
Eletrocardiografia
Eletroencefalografia
Epilepsia Motora Parcial/diagnóstico
Epilepsia Motora Parcial/terapia
Doenças do Nervo Glossofaríngeo/diagnóstico
Doenças do Nervo Glossofaríngeo/terapia
Espasmo Hemifacial/diagnóstico
Espasmo Hemifacial/terapia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Cirurgia de Descompressão Microvascular/métodos
Neuralgia/diagnóstico
Neuralgia/terapia
Parada Sinusal Cardíaca/diagnóstico
Parada Sinusal Cardíaca/terapia
Síncope/diagnóstico
Síncope/terapia
Doenças do Nervo Vago/diagnóstico
Doenças do Nervo Vago/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
33CM23913M (Carbamazepine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160726
[Lr] Data última revisão:
160726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


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[PMID]:27379499
[Au] Autor:Berti de Marinis G; Novello S; Ferrari S; Barzon I; Cortella I; Businaro MA; Fabris F; Lombardi AM
[Ad] Endereço:Emergency Department, University Hospital of Padova, Via Giustiniani n.2, 35128, Padua, Italy. giulia.bdm@gmail.com.
[Ti] Título:Correlation between ADAMTS13 activity and neurological impairment in acute thrombotic microangiopathy patients.
[So] Source:J Thromb Thrombolysis;42(4):586-92, 2016 Nov.
[Is] ISSN:1573-742X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Differential diagnosis between thrombotic thrombocytopenic purpura (TTP) and other thrombotic microangiopathies (TMA) is usually difficult because of frequently overlapping clinical presentations. Severely depressed ADAMTS13 activity (<10 %) seems distinctive for TTP because of its pathogenetic role. However a long debate exists in the literature about its sensibility and specificity. Our aim was to search for clinical differences between TMA patients referred to our laboratory, comparing them for protease activity <10 versus ≥10 %. ADAMTS13 activity ≥10 % patients (n = 73) showed a higher prevalence of drug- (p = 0.005) and cancer-associated (p < 0.001) TMA. Mean platelet count and renal dysfunction prevalence was lower (p < 0.001), while neurological impairment was more frequent (p = 0.001) in the <10 % ADAMTS13 activity group (n = 109), confirming previous literature findings. When taken neurological manifestations singularly, epilepsy (p = 0.04), focal motor deficit (p < 0.001) and cranial nerve palsy (p = 0.007) were more frequent in the <10 % activity group. In our case series, a <10 % ADAMTS13 activity depicts a group of patients with clinical features similar to TTP patients. Focal motor impairment or epileptic manifestations could further address toward a TTP diagnosis. Studies about treatment efficacy and follow-up are advised to determine whether laboratory findings can guide therapeutic decisions.
[Mh] Termos MeSH primário: Proteína ADAMTS13/sangue
Doenças dos Nervos Cranianos/sangue
Epilepsia Motora Parcial/sangue
Microangiopatias Trombóticas/sangue
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Idoso
Doenças dos Nervos Cranianos/etiologia
Epilepsia Motora Parcial/etiologia
Feminino
Seres Humanos
Nefropatias/sangue
Masculino
Volume Plaquetário Médio
Meia-Idade
Neoplasias/sangue
Microangiopatias Trombóticas/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.87 (ADAMTS13 Protein); EC 3.4.24.87 (ADAMTS13 protein, human)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE
[do] DOI:10.1007/s11239-016-1395-7


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[PMID]:26898965
[Au] Autor:Anzellotti F; Capasso M; Frazzini V; Onofrj M
[Ad] Endereço:SS Annunziata Hospital of Chieti- Neurology, Chieti, Abruzzo, Italy.
[Ti] Título:Olanzapine-related repetitive focal seizures with lingual dystonia.
[So] Source:Epileptic Disord;18(1):83-6, 2016 Mar.
[Is] ISSN:1950-6945
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Olanzapine-related seizures have rarely been reported despite associated proconvulsant risk factors described in the literature: myoclonic status, increased frequency of seizures, tonic-clonic seizures, as well as fatal status epilepticus. We present a psychiatric patient who developed repetitive focal motor seizures and lingual dystonia when olanzapine was added for psychomotor agitation and aggressiveness. Olanzapine was immediately suspended and the seizures progressively disappeared. A control EEG showed no paroxysmal discharges. Olanzapine shares some pharmacological similarities with clozapine, a neuroleptic with a high risk of dose-dependent seizures. This adverse effect should be taken into account, and olanzapine should be used with caution if concomitant circumstances decrease the seizure threshold. [Published with video sequence online].
[Mh] Termos MeSH primário: Antipsicóticos/efeitos adversos
Benzodiazepinas/efeitos adversos
Distonia/induzido quimicamente
Epilepsia Motora Parcial/induzido quimicamente
Convulsões/induzido quimicamente
[Mh] Termos MeSH secundário: Distonia/tratamento farmacológico
Eletroencefalografia/métodos
Epilepsia Motora Parcial/diagnóstico
Epilepsia Motora Parcial/tratamento farmacológico
Seres Humanos
Masculino
Meia-Idade
Convulsões/complicações
Convulsões/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 12794-10-4 (Benzodiazepines); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160223
[St] Status:MEDLINE
[do] DOI:10.1684/epd.2016.0805


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[PMID]:26660199
[Au] Autor:Sitthinamsuwan B; Usui N; Tottori T; Terada K; Kondo A; Matsuda K; Baba K; Inoue Y
[Ad] Endereço:National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.
[Ti] Título:Seizures with tonic posturing: Semiologic difference between supplementary sensorimotor area (SSMA) origin and extra-SSMA origin.
[So] Source:Epilepsia;57(2):e39-44, 2016 Feb.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In seizures with tonic posturing, differentiation of seizures originating in SSMA from seizures originating in cortices other than SSMA and spreading to SSMA has not been previously attempted. Twenty-two patients were studied with intractable focal epilepsy with tonic limb posturing as the most prominent semiology, who underwent resective surgery and obtained favorable postoperative seizure outcomes. These 22 patients were divided into an SSMA group (N = 12) and an extra-SSMA group (N = 10), according to the location of resection. Resection area in the extra-SSMA group was located in the dorsolateral frontal or prefrontal area in four patients, the frontal operculum (insula) in two, the parietal cortex in three, and the temporoparietal cortex in one patient. Video-recorded seizures were carefully reviewed. Tonic posturing characteristics and the presence or absence of accompanying symptoms were compared between groups. Incidence of preservation of consciousness was significantly higher in the SSMA group (p < 0.001). Patients in the SSMA group demonstrated a propensity for having unilateral or bilateral asymmetrical tonic limb posturing. In contrast, patients in the extra-SSMA group had a statistically significantly higher incidence of bilateral symmetrical tonic limb posturing (p < 0.05). These findings may be helpful in identifying seizure origin.
[Mh] Termos MeSH primário: Epilepsia Resistente a Medicamentos/fisiopatologia
Epilepsia Motora Parcial/fisiopatologia
Lobo Parietal/fisiopatologia
Córtex Pré-Frontal/fisiopatologia
Córtex Sensório-Motor/fisiopatologia
Lobo Temporal/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Neoplasias Encefálicas/complicações
Criança
Pré-Escolar
Epilepsia Resistente a Medicamentos/etiologia
Epilepsia Resistente a Medicamentos/cirurgia
Eletroencefalografia
Epilepsias Parciais/etiologia
Epilepsias Parciais/fisiopatologia
Epilepsias Parciais/cirurgia
Epilepsia Motora Parcial/etiologia
Epilepsia Motora Parcial/cirurgia
Feminino
Lobo Frontal/fisiopatologia
Lobo Frontal/cirurgia
Gliose/complicações
Hemangioma Cavernoso do Sistema Nervoso Central/complicações
Seres Humanos
Malformações Arteriovenosas Intracranianas/complicações
Imagem por Ressonância Magnética
Masculino
Malformações do Desenvolvimento Cortical/complicações
Lobo Parietal/cirurgia
Córtex Pré-Frontal/cirurgia
Córtex Sensório-Motor/cirurgia
Lobo Temporal/cirurgia
Gravação em Vídeo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160206
[Lr] Data última revisão:
160206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13283


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[PMID]:26380424
[Au] Autor:Dömötör J; Clemens B
[Ti] Título:[FOCAL MOTOR SEIZURES AND STATUS EPILEPTICUS PROVOKED BY MIRTAZAPINE].
[Ti] Título:MIRTAZAPIN ÁLTAL PROVOKÁLT FOKÁLIS MOTOROS ROHAMOK ÉS STATUS EPILEPTICUS..
[So] Source:Ideggyogy Sz;68(7-8):286-8, 2015 Jul 30.
[Is] ISSN:0019-1442
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:The seizure-provoking effect of the tetracyclic antidepressant mirtazapine is not a well-known adverse effect of the drug. The authors report on a 39-year-old non-epileptic patient who had been treated for depression with the usual daily dose of mirtazapine. Having increased the daily dose of the drug from 30 to 45 milligrams he experienced a few clonic seizures of the right lower limb. This symptom and insomnia erroneously intended the patient to further increase the daily dose of mirtazapine, which immediately resulted in the evolution of focal clonic status epilepticus in the same limb. After admission, this condition was recorded by video-EEG and abolished by intravenous administration of levetiracetam after the intravenous clonazepam had been ineffective. Discontinuation of mirtazapine and administration of carbamazepine resulted in completely seizure-free state that persisted even after carbamazepine treatment was terminated. The clinical and laboratory data indicate the seizure-provoking effect of mirtazapine in the reported case.
[Mh] Termos MeSH primário: Antidepressivos Tricíclicos/efeitos adversos
Epilepsia Motora Parcial/induzido quimicamente
Mianserina/análogos & derivados
Estado Epiléptico/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Anticonvulsivantes/administração & dosagem
Antidepressivos Tricíclicos/administração & dosagem
Carbamazepina/administração & dosagem
Eletroencefalografia/métodos
Epilepsia Motora Parcial/tratamento farmacológico
Epilepsia Motora Parcial/fisiopatologia
Seres Humanos
Masculino
Mianserina/administração & dosagem
Mianserina/efeitos adversos
Piracetam/administração & dosagem
Piracetam/análogos & derivados
Estado Epiléptico/tratamento farmacológico
Estado Epiléptico/fisiopatologia
Gravação em Vídeo
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Antidepressive Agents, Tricyclic); 230447L0GL (etiracetam); 250PJI13LM (Mianserin); 33CM23913M (Carbamazepine); A051Q2099Q (mirtazapine); ZH516LNZ10 (Piracetam)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150918
[Lr] Data última revisão:
150918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150919
[St] Status:MEDLINE



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