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[PMID]:25062304
[Au] Autor:Fang T; Yan R; Fang F
[Ad] Endereço:Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University;
[Ti] Título:Spontaneous out-of-body experience in a child with refractory right temporoparietal epilepsy.
[So] Source:J Neurosurg Pediatr;14(4):396-9, 2014 Oct.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The authors describe the case of a spontaneous out-of-body experience (OBE) in a 15-year-old right-handed boy with intractable epilepsy in whom psychosis had been misdiagnosed. After successful resection of a right temporoparietal focal cortical dysplasia, the OBE and seizures resolved. The authors analyzed the underlying causes of the OBE and discussed the mechanism of the OBE caused by an epileptic lesion.
[Mh] Termos MeSH primário: Cognição
Epilepsia/psicologia
Epilepsia/cirurgia
Malformações do Desenvolvimento Cortical/diagnóstico
Malformações do Desenvolvimento Cortical/psicologia
Lobo Parietal/patologia
Senso de Coerência
Lobo Temporal/patologia
[Mh] Termos MeSH secundário: Adolescente
Erros de Diagnóstico
Eletroencefalografia
Epilepsia/patologia
Epilepsia/fisiopatologia
Epilepsia Parcial Sensorial/diagnóstico
Epilepsia Parcial Sensorial/psicologia
Epilepsia do Lobo Temporal/psicologia
Epilepsia do Lobo Temporal/cirurgia
Seres Humanos
Masculino
Malformações do Desenvolvimento Cortical/fisiopatologia
Malformações do Desenvolvimento Cortical/cirurgia
Lobo Parietal/fisiopatologia
Lobo Parietal/cirurgia
Transtornos Psicóticos/diagnóstico
Lobo Temporal/fisiopatologia
Lobo Temporal/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1502
[Cu] Atualização por classe:150312
[Lr] Data última revisão:
150312
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140726
[St] Status:MEDLINE
[do] DOI:10.3171/2014.6.PEDS13485


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[PMID]:24721199
[Au] Autor:Magini P; Bisulli F; Baldassari S; Stipa C; Naldi I; Licchetta L; Menghi V; Tinuper P; Seri M; Pippucci T
[Ad] Endereço:U.O. Medical Genetics, Polyclinic Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy. Electronic address: pamela.magini@unibo.it.
[Ti] Título:LGI1 microdeletions are not a frequent cause of partial epilepsy with auditory features (PEAF).
[So] Source:Epilepsy Res;108(5):972-7, 2014 Jul.
[Is] ISSN:1872-6844
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Heterozygous mutations of the leucine-rich, glioma-inactivated 1 gene (LGI1) are the major known cause of partial epilepsy with auditory features (PEAF), accounting for roughly 50% of families. Recently, a partial gene microdeletion has been reported in a single family. To assess the contribution of LGI1 microrearrangements to the pathogenesis of PEAF, we screened 50 patients negative for point mutations through multiplex ligation-dependent probe amplification (MLPA) analysis. No cryptic imbalances were found in LGI1, suggesting that LGI1 microdeletions are not a frequent cause of PEAF. Despite the small number of examined patients and the need for replication studies, these findings support the hypothesis that diagnostic screening for LGI1 microrearrangements lacks clinical utility, especially for sporadic cases, and further highlight genetic heterogeneity of familial and sporadic PEAF.
[Mh] Termos MeSH primário: Epilepsia Parcial Sensorial/genética
Proteínas/genética
Deleção de Sequência
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Análise Mutacional de DNA
Feminino
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase Multiplex
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (LGI1 protein, human); 0 (Proteins)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140519
[Lr] Data última revisão:
140519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140412
[St] Status:MEDLINE


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[PMID]:23903052
[Au] Autor:Hashimoto R; Voigt B; Ishimaru Y; Hokao R; Chiba S; Serikawa T; Sasa M; Kuramoto T
[Ad] Endereço:Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
[Ti] Título:Identification of QTLs involved in the development of amygdala kindling in the rat.
[So] Source:Exp Anim;62(3):181-7, 2013.
[Is] ISSN:1881-7122
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Amygdala kindling is useful for modeling human epilepsy development. It has been known that genetic factors are involved in the development of amygdala kindling. The purpose of this study was to identify the loci that are responsible for the development of amygdala kindling. To achieve this, rat strains from a LEXF/FXLE recombinant inbred (RI) strain panel were used. The phenotypes of amygdala kindling-related parameters for seven RI strains and parental LE/Stm and F344/Stm strains were determined. They included the afterdischarge threshold (ADT), the afterdischarge duration (ADD), and the kindling rate, an incidence of development of kindling. Quantitative trait loci (QTL) analysis was performed to identify linkage relationships between these phenotypes and 1,033 SNP markers. Although no significant differences in pre-kindling ADT and ADD were observed, a significant difference in the kindling rate was found for the LEXF/FXLE RI strain. Two QTLs for the amygdala kindling rate (Agkr1 and Agkr2) were identified on rat chromosome 2. These findings clearly prove the existence of genetic influences that are involved in kindling development and suggest that substantial genetic components contribute to the progression of partial seizures into generalized seizures.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/fisiopatologia
Modelos Animais de Doenças
Epilepsia/genética
Excitação Neurológica/genética
Locos de Características Quantitativas/genética
Ratos Endogâmicos
[Mh] Termos MeSH secundário: Animais
Epilepsia Parcial Sensorial/genética
Seres Humanos
Masculino
Fenótipo
Polimorfismo de Nucleotídeo Único
Ratos Endogâmicos F344
Ratos Long-Evans
Convulsões/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1401
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130802
[St] Status:MEDLINE


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[PMID]:23860375
[Au] Autor:Harris S; Bruyns-Haylett M; Kennerley A; Boorman L; Overton PG; Ma H; Zhao M; Schwartz TH; Berwick J
[Ad] Endereço:1] Department of Psychology, University of Sheffield, Sheffield, UK [2] Department of Neurological Surgery, Brain and Spine Center, Brain and Mind Research Institute, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, USA.
[Ti] Título:The effects of focal epileptic activity on regional sensory-evoked neurovascular coupling and postictal modulation of bilateral sensory processing.
[So] Source:J Cereb Blood Flow Metab;33(10):1595-604, 2013 Oct.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While it is known that cortical sensory dysfunction may occur in focal neocortical epilepsy, it is unknown whether sensory-evoked neurovascular coupling is also disrupted during epileptiform activity. Addressing this open question may help to elucidate both the effects of focal neocortical epilepsy on sensory responses and the neurovascular characteristics of epileptogenic regions in sensory cortex. We therefore examined bilateral sensory-evoked neurovascular responses before, during, and after 4-aminopyridine (4-AP, 15 mmol/L, 1 µL) induced focal neocortical seizures in right vibrissal cortex of the rat. Stimulation consisted of electrical pulse trains (16 seconds, 5 Hz, 1.2 mA) presented to the mystacial pad. Consequent current-source density neural responses and epileptic activity in both cortices and across laminae were recorded via two 16-channel microelectrodes bilaterally implanted in vibrissal cortices. Concurrent two-dimensional optical imaging spectroscopy was used to produce spatiotemporal maps of total, oxy-, and deoxy-hemoglobin concentration. Compared with control, sensory-evoked neurovascular coupling was altered during ictal activity, but conserved postictally in both ipsilateral and contralateral vibrissal cortices, despite neurovascular responses being significantly reduced in the former, and enhanced in the latter. Our results provide insights into sensory-evoked neurovascular dynamics and coupling in epilepsy, and may have implications for the localization of epileptogenic foci and neighboring eloquent cortex.
[Mh] Termos MeSH primário: Epilepsia Parcial Sensorial/fisiopatologia
Potenciais Somatossensoriais Evocados/fisiologia
Hemodinâmica/fisiologia
Neocórtex
Vias Neurais/fisiopatologia
Córtex Somatossensorial/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Feminino
Lateralidade Funcional
Hemoglobinas/análise
Microeletrodos
Neocórtex/irrigação sanguínea
Neocórtex/fisiopatologia
Imagem Óptica
Oxigênio/sangue
Estimulação Física
Ratos
Ratos Endogâmicos
Vibrissas/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hemoglobins); S88TT14065 (Oxygen)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130718
[St] Status:MEDLINE
[do] DOI:10.1038/jcbfm.2013.115


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[PMID]:22998002
[Au] Autor:Marynissen T; Govers N; Vydt T
[Ad] Endereço:Dept. of Cardiology, St.-Maarten Hospital, Mechelen and Duffel, Belgium. thomas.marynissen@student.kuleuven.be
[Ti] Título:Ictal asystole: case report with review of literature.
[So] Source:Acta Cardiol;67(4):461-4, 2012 Aug.
[Is] ISSN:0001-5385
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cardiac arrhythmias are frequently observed during epileptic seizures. Mostly they are benign, but severe bradycardia and asystole occur in 0.27-0.5% of patients who have seizures on video-EEG monitoring units. Especially patients with partial seizures involving the insular, orbital frontal and anterior temporal lobe regions, are at risk. Ictal bradycardia could be a cause of SUDEP (sudden unexpected death in epilepsy) and pacemaker insertion might therefore improve survival in selected cases, although more research is needed to prove this. We present a case of prolonged ictal asystole in a patient with newly diagnosed partial epilepsy originating from the temporal lobe.
[Mh] Termos MeSH primário: Arritmias Cardíacas/complicações
Epilepsia Parcial Sensorial/complicações
Epilepsia do Lobo Temporal/complicações
[Mh] Termos MeSH secundário: Bradicardia/complicações
Eletrocardiografia
Parada Cardíaca
Seres Humanos
Masculino
Meia-Idade
Transtornos do Olfato/etiologia
Inconsciência/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1210
[Cu] Atualização por classe:170511
[Lr] Data última revisão:
170511
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120925
[St] Status:MEDLINE


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[PMID]:22642646
[Au] Autor:Ponnusamy A; Marques JL; Reuber M
[Ad] Endereço:Department of Clinical Neurophysiology, Royal Hallamshire Hospital, Sheffield, United Kingdom. athi.ponnusamy@sth.nhs.uk
[Ti] Título:Comparison of heart rate variability parameters during complex partial seizures and psychogenic nonepileptic seizures.
[So] Source:Epilepsia;53(8):1314-21, 2012 Aug.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Psychogenic nonepileptic seizures (PNES) superficially resemble epileptic seizures. Little is known about ictal autonomic nervous system (ANS) activity changes in epilepsy and PNES. This study compares ictal heart rate variability (HRV) parameters as a reflection of ANS tone in epileptic seizures and PNES, and explores differences between interictal and ictal ANS tone in both patient groups. METHODS: Ictal HRV parameters were extracted from single-lead electrocardiography (ECG) data collected during video-electroencephalography (EEG) recordings of 26 patients with medically refractory temporal lobe epilepsy and 24 age- and sex-matched patients with PNES. One seizure per patient in a resting, wake, supine state was analyzed. Interictal ECG data were available for comparison from 14 patients in both groups. HRV parameters in time and frequency domains were analyzed (low frequency [LF], high frequency [HF], standard deviation of all consecutive normal R wave intervals [SDNN], square root of the mean of the sum of the squares of differences between adjacent normal R wave intervals [RMSSD]). CVI (cardiovagal index), CSI (cardiosympathetic index), and ApEn (approximate entropy) were calculated from Lorenz plots. KEY FINDINGS: There were significant differences between ictal HRV measures during epileptic and nonepileptic seizures in the time and frequency domains. CSI (p < 0.001) was higher in epileptic seizures. Time interval between two consecutive R waves in the ECG (RR interval) (p = 0.002), LF (p = 0.02), HF (p = 0.003), and RMSSD (p = 0.003) were significantly lower during epileptic seizures. Binary logistic regression yielded a significant model based on the differences in CSI classifying 88% of patients with epilepsy and 73% of patients with PNES correctly. The comparison between resting and ictal states in both seizure disorders revealed significant differences in RR interval (epilepsy p < 0.001, PNES p = 0.01), CSI (epilepsy p < 0.001, PNES p = 0.02), HF (epilepsy p = 0.002, PNES p = 0.03), and RMSSD (epilepsy p = 0.004, PNES p = 0.04). In patients with epilepsy there were also significant differences in ictal versus interictal mean values of ApEn (p = 0.03) and LF (p = 0.04). Although CSI was significantly higher, the other parameters were lower during the seizures. Stepwise binary regression in the 14 patients with epilepsy produced a significant model differentiating resting state from seizures in 100% of cases. The same statistical approach did not yield a significant model in the PNES group. SIGNIFICANCE: Our results show greater ANS activation in epileptic seizures than in PNES. The biggest ictal HRV changes associated with epileptic seizures (CSI, HF, and RMSSD) reflect high sympathetic system activation and reduced vagal tone. The reduced ApEn also reflects a high sympathetic tone. The observed ictal alterations of HRV patterns may be a more specific marker of epileptic seizures than heart rate changes alone. These altered HRV patterns could be used to detect seizures and also to differentiate epileptic seizures from PNES. Larger studies are justified with intergroup and intragroup comparisons between ictal and resting states.
[Mh] Termos MeSH primário: Epilepsia Parcial Sensorial/fisiopatologia
Frequência Cardíaca/fisiologia
Convulsões/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Encéfalo/fisiopatologia
Eletroencefalografia
Epilepsia Parcial Sensorial/etiologia
Feminino
Coração/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Convulsões/etiologia
Gravação em Vídeo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1210
[Cu] Atualização por classe:120813
[Lr] Data última revisão:
120813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120531
[St] Status:MEDLINE
[do] DOI:10.1111/j.1528-1167.2012.03518.x


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[PMID]:22000619
[Au] Autor:El Assasse L; En-Nafaa I; Amraoui F; Chaouir S; Amil T; Darbi A
[Ti] Título:[Rasmussen's encephalitis of the adult: a case report].
[Ti] Título:Encéphalite de Rasmussen chez l'adulte : à propos d'un cas..
[So] Source:J Radiol;92(10):942-4, 2011 Oct.
[Is] ISSN:1773-0384
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Córtex Cerebral/patologia
Eletroencefalografia
Encefalite/diagnóstico
Epilepsia Motora Parcial/diagnóstico
Epilepsia Parcial Sensorial/diagnóstico
Interpretação de Imagem Assistida por Computador
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Adulto
Atrofia
Diagnóstico Diferencial
Dominância Cerebral/fisiologia
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1205
[Cu] Atualização por classe:111017
[Lr] Data última revisão:
111017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111018
[St] Status:MEDLINE
[do] DOI:10.1016/j.jradio.2011.05.011


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[PMID]:21488712
[Au] Autor:Simoens S
[Ad] Endereço:Research Centre for Pharmaceutical Care and Pharmaco-economics, Katholieke Universiteit Leuven, Onderwijs en Navorsing 2, Herestraat 49, 3000 Leuven, Belgium. steven.simoens@pharm.kuleuven.be
[Ti] Título:Budget impact analysis of adjunctive therapy with lacosamide for partial-onset epileptic seizures in Belgium.
[So] Source:J Med Econ;14(3):299-304, 2011.
[Is] ISSN:1941-837X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aims to compute the budget impact of lacosamide, a new adjunctive therapy for partial-onset seizures in epilepsy patients from 16 years of age who are uncontrolled and having previously used at least three anti-epileptic drugs from a Belgian healthcare payer perspective. METHODS: The budget impact analysis compared the 'world with lacosamide' to the 'world without lacosamide' and calculated how a change in the mix of anti-epileptic drugs used to treat uncontrolled epilepsy would impact drug spending from 2008 to 2013. Data on the number of patients and on the market shares of anti-epileptic drugs were taken from Belgian sources and from the literature. Unit costs of anti-epileptic drugs originated from Belgian sources. The budget impact was calculated from two scenarios about the market uptake of lacosamide. RESULTS: The Belgian target population is expected to increase from 5333 patients in 2008 to 5522 patients in 2013. Assuming that the market share of lacosamide increases linearly over time and is taken evenly from all other anti-epileptic drugs (AEDs), the budget impact of adopting adjunctive therapy with lacosamide increases from €5249 (0.1% of reference drug budget) in 2008 to €242,700 (4.7% of reference drug budget) in 2013. Assuming that 10% of patients use standard AED therapy plus lacosamide, the budget impact of adopting adjunctive therapy with lacosamide is around €800,000-900,000 per year (or 16.7% of the reference drug budget). CONCLUSIONS: Adjunctive therapy with lacosamide would raise drug spending for this patient population by as much as 16.7% per year. However, this budget impact analysis did not consider the fact that lacosamide reduces costs of seizure management and withdrawal. The literature suggests that, if savings in other healthcare costs are taken into account, adjunctive therapy with lacosamide may be cost saving.
[Mh] Termos MeSH primário: Acetamidas/economia
Anticonvulsivantes/economia
Orçamentos/tendências
Epilepsia Parcial Sensorial/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetamidas/administração & dosagem
Acetamidas/uso terapêutico
Adolescente
Anticonvulsivantes/administração & dosagem
Anticonvulsivantes/uso terapêutico
Bélgica
Custos de Medicamentos/tendências
Epilepsia Parcial Sensorial/epidemiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetamides); 0 (Anticonvulsants); 563KS2PQY5 (lacosamide)
[Em] Mês de entrada:1109
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110415
[St] Status:MEDLINE
[do] DOI:10.3111/13696998.2011.577852


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[PMID]:21145169
[Au] Autor:Chen WT; Wang SJ; Fuh JL; Lin CP; Ko YC; Lin YY
[Ad] Endereço:Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
[Ti] Título:Persistent ictal-like visual cortical excitability in chronic migraine.
[So] Source:Pain;152(2):254-8, 2011 Feb.
[Is] ISSN:1872-6623
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Episodic migraine (EM) may evolve into the more disabling chronic migraine (CM, monthly migraine days ≥ 8 and headache days ≥ 15) with unknown mechanism. Aiming to elucidate the pathophysiology of CM and its relationship with EM, this study characterized the visual cortical responses in CM and EM. Neuromagnetic visual-evoked responses to left-hemifield checkerboard reversals were obtained in patients with EM (interictal or ictal states), CM (interictal) and age-matched controls. For each subject, the 1500 evoked responses were sequentially divided into 30 blocks and percentage changes of P100m amplitude in blocks 2, 9, 16, 23, and 30 compared to the first block were computed to assess habituation. At the end of visual stimulation (block 30), P100m amplitude was decreased (habituated) in the controls (n=32) (35.2±2.6nAm vs. 41.9±2.7, p=0.005) but increased (potentiated) in the interictal state of EM (n=29) (39.7±3.8 vs. 33.5±3.0, p=0.007). In CM (n=25), P100m was habituated (46.5±2.9 vs. 51.6±3.7, p=0.013) but higher at the initial block than in those of the interictal state of EM (p=0.001). These CM features also characterized the P100m in the ictal state of EM (n=9). There was no difference of P100m between CM and ictal state of EM. In conclusion, patients with CM demonstrate a persistent ictal-like excitability pattern of the visual cortex between migraine attacks which may implicate central inhibitory dysfunction.
[Mh] Termos MeSH primário: Potenciais Evocados Visuais/fisiologia
Habituação Psicofisiológica/fisiologia
Transtornos de Enxaqueca/fisiopatologia
Córtex Visual/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Epilepsia Parcial Sensorial/complicações
Epilepsia Parcial Sensorial/diagnóstico
Epilepsia Parcial Sensorial/fisiopatologia
Feminino
Seres Humanos
Masculino
Transtornos de Enxaqueca/diagnóstico
Transtornos de Enxaqueca/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1112
[Cu] Atualização por classe:110117
[Lr] Data última revisão:
110117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101215
[St] Status:MEDLINE
[do] DOI:10.1016/j.pain.2010.08.047


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[PMID]:20712852
[Au] Autor:Baskerville JR
[Ad] Endereço:(jerry@jrbaskerville.com) CHRISTUS Spohn Memorial Hospital EM Residency Program Corpus Christi, TX Supervising Editor: Brian Zink, MD.
[Ti] Título:Observer and subject bias: lessons from procrustes.
[So] Source:Acad Emerg Med;17(9):1032, 2010 Sep.
[Is] ISSN:1553-2712
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Epilepsia Parcial Sensorial/diagnóstico
[Mh] Termos MeSH secundário: Competência Clínica
Diagnóstico Diferencial
Seres Humanos
Variações Dependentes do Observador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1102
[Cu] Atualização por classe:100914
[Lr] Data última revisão:
100914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100818
[St] Status:MEDLINE
[do] DOI:10.1111/j.1553-2712.2010.00833.x



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