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[PMID]:29352316
[Au] Autor:Myers KA; McGlade A; Neubauer BA; Lal D; Berkovic SF; Scheffer IE; Hildebrand MS
[Ad] Endereço:Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.
[Ti] Título:KANSL1 variation is not a major contributing factor in self-limited focal epilepsy syndromes of childhood.
[So] Source:PLoS One;13(1):e0191546, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: KANSL1 haploinsufficiency causes Koolen-de Vries syndrome (KdVS), characterized by dysmorphic features and intellectual disability; amiable personality, congenital malformations and seizures also commonly occur. The epilepsy phenotypic spectrum in KdVS is broad, but most individuals have focal seizures with some having a phenotype resembling the self-limited focal epilepsies of childhood (SFEC). We hypothesized that variants in KANSL1 contribute to pathogenesis of SFEC. MATERIALS AND METHODS: We screened KANSL1 for single nucleotide variants in 90 patients with SFEC. We then screened a cohort of 208 patients with two specific SFEC syndromes, childhood epilepsy with centrotemporal spikes (CECTS) and atypical childhood epilepsy with centrotemporal spikes (ACECTS) for KANSL1 variants. The second cohort was also used to evaluate minor allelic variants that appeared overrepresented in the initial cohort. RESULTS: One variant, p.Lys104Thr, was predicted damaging and appeared overrepresented in our 90-patient cohort compared to Genome Aggregation Database (gnomAD) allele frequency (0.217 to 0.116, with no homozygotes in gnomAD). However, there was no difference in p.Lys104Thr allele frequency in the follow-up CECTS/ACECTS cohort and controls. Four rare KANSL1 variants of uncertain significance were identified in the CECTS/ACECTS cohort. DISCUSSION: Our data do not support a major role for KANSL1 variants in pathogenesis of SFEC.
[Mh] Termos MeSH primário: Síndromes Epilépticas/genética
Proteínas Nucleares/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/genética
Substituição de Aminoácidos
Criança
Deleção Cromossômica
Cromossomos Humanos Par 17/genética
Estudos de Coortes
Bases de Dados Genéticas
Epilepsias Parciais/genética
Epilepsia Rolândica/genética
Síndromes Epilépticas/etiologia
Frequência do Gene
Variação Genética
Seres Humanos
Deficiência Intelectual/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (KANSL1 protein, human); 0 (Nuclear Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191546


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[PMID]:28801973
[Au] Autor:Wickens S; Bowden SC; D'Souza W
[Ad] Endereço:Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
[Ti] Título:Cognitive functioning in children with self-limited epilepsy with centrotemporal spikes: A systematic review and meta-analysis.
[So] Source:Epilepsia;58(10):1673-1685, 2017 Oct.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: It is now well appreciated that benign epilepsy with centrotemporal spikes (BECTS, or more recently, ECTS) is associated with a range of cognitive and behavioral disturbances. Despite our improved understanding of cognitive functioning in ECTS, there have been to date no efforts to quantitatively synthesize the available literature within a comprehensive cognitive framework. METHODS: The present systematic review and meta-analysis was conducted according to PRISMA guidelines. Forty-two case-control samples met eligibility criteria comprising a total of 1,237 children with ECTS and 1,137 healthy control children. Univariate, random-effects meta-analyses were conducted on eight cognitive factors in accordance with the Cattell-Horn-Carroll model of intelligence. RESULTS: Overall, children with ECTS demonstrated significantly lower scores on neuropsychological tests across all cognitive factors compared to healthy controls. Observed effects ranged from 0.42 to 0.81 pooled standard deviation units, with the largest effect for long-term storage and retrieval and the smallest effect for visual processing. SIGNIFICANCE: The results of the present meta-analysis provide the first clear evidence that children with ECTS display a profile of pervasive cognitive difficulties and thus challenge current conceptions of ECTS as a benign disease or of limited specific or localized cognitive effect.
[Mh] Termos MeSH primário: Cognição
Epilepsia Rolândica/psicologia
[Mh] Termos MeSH secundário: Criança
Epilepsia/psicologia
Seres Humanos
Testes Neuropsicológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13865


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[PMID]:28762475
[Au] Autor:Ciumas C; Laurent A; Saignavongs M; Ilski F; de Bellescize J; Panagiotakaki E; Ostrowsky-Coste K; Arzimanoglou A; Herbillon V; Ibarrola D; Ryvlin P
[Ad] Endereço:Translational and Integrative Group in Epilepsy Research (TIGER), INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, University Lyon 1, Lyon, France.
[Ti] Título:Behavioral and fMRI responses to fearful faces are altered in benign childhood epilepsy with centrotemporal spikes (BCECTS).
[So] Source:Epilepsia;58(10):1716-1727, 2017 Oct.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We hypothesized that children with benign childhood epilepsy with centrotemporal spikes (BCECTS) might have altered social cognitive skills and underlying neural networks. METHODS: We studied 13 patients with BCECTS and 11 age-matched controls using event-related functional magnetic resonance imaging (fMRI) with an emotional discrimination task consisting of viewing happy, fearful, scrambled, and neutral faces. Behavioral performance measured during the task was correlated with clinical variables and behavioral ratings. RESULTS: In comparison with age-matched controls, children with BCECTS performing a fearful faces detection task showed significantly reduced bilateral fMRI activation in the insular cortex, caudate, and lentiform nuclei, as well as increased response time. The percentage of errors made by children with BCECTS correlated negatively with age, a finding not observed in controls. In patients, accuracy positively correlated with time since the last seizure. The above abnormalities were not observed during happy faces detection task, except for a slower response in children with BCECTS as compared to controls. SIGNIFICANCE: Our study suggests that BCECTS is associated with altered social cognition network and function, particularly for the identification of fearful faces. The age dependency of some of these findings supports the view that a delayed maturation of spiking cortical regions might underlie the cognitive dysfunction observed in BCECTS.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Epilepsia Rolândica/fisiopatologia
Reconhecimento Facial/fisiologia
Medo
Felicidade
Percepção Social
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Núcleo Caudado/fisiopatologia
Córtex Cerebral/fisiopatologia
Criança
Corpo Estriado/fisiopatologia
Epilepsia Rolândica/psicologia
Potenciais Evocados
Expressão Facial
Feminino
Neuroimagem Funcional
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Convulsões
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13858


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[PMID]:28391031
[Au] Autor:Verly M; Gerrits R; Lagae L; Sunaert S; Rommel N; Zink I
[Ad] Endereço:Dept. Neurosciences, ExpORL, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: marjolein.verly@kuleuven.be.
[Ti] Título:Evaluation of the language profile in children with rolandic epilepsy and developmental dysphasia: Evidence for distinct strengths and weaknesses.
[So] Source:Brain Lang;170:18-28, 2017 Jul.
[Is] ISSN:1090-2155
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Although benign, rolandic epilepsy (RE) or benign childhood epilepsy with centro-temporal spikes is often associated with language impairment. Recently, fronto-rolandic EEG abnormalities have been described in children with developmental dysphasia (DD), suggesting an interaction between language impairment and interictal epileptiform discharges. To investigate if a behavioral-linguistic continuum between RE and DD exists, a clinical prospective study was carried out to evaluate the language profile of 15 children with RE and 22 children with DD. Language skills were assessed using an extensive, standardized test battery. Language was found to be impaired in both study groups, however RE and DD were associated with distinct language impairment profiles. Children with RE had difficulties with sentence comprehension, semantic verbal fluency and auditory short-term memory, which are unrelated to age of epilepsy onset and laterality of epileptic focus. In children with DD, sentence comprehension and verbal fluency were among their relative strengths, whereas sentence and lexical production constituted relative weaknesses.
[Mh] Termos MeSH primário: Afasia/complicações
Afasia/fisiopatologia
Epilepsia Rolândica/complicações
Epilepsia Rolândica/fisiopatologia
Transtornos da Linguagem/complicações
Transtornos da Linguagem/fisiopatologia
Linguagem
[Mh] Termos MeSH secundário: Idade de Início
Afasia/diagnóstico
Criança
Pré-Escolar
Compreensão
Eletroencefalografia
Epilepsia Rolândica/diagnóstico
Feminino
Lateralidade Funcional
Seres Humanos
Testes de Linguagem
Linguística
Masculino
Memória de Curto Prazo
Testes Neuropsicológicos
Estudos Prospectivos
Semântica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


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[PMID]:28384699
[Au] Autor:Doumlele K; Friedman D; Buchhalter J; Donner EJ; Louik J; Devinsky O
[Ad] Endereço:Department of Neurology, New York University School of Medicine, New York.
[Ti] Título:Sudden Unexpected Death in Epilepsy Among Patients With Benign Childhood Epilepsy With Centrotemporal Spikes.
[So] Source:JAMA Neurol;74(6):645-649, 2017 Jun 01.
[Is] ISSN:2168-6157
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Children with benign epilepsy with centrotemporal spikes (BECTS) have traditionally been considered to have a uniformly good prognosis. However, benign may be a misnomer because BECTS is linked to cognitive deficits, a more severe phenotype with intractable seizures, and the potential for sudden unexpected death in epilepsy (SUDEP). Objective: To determine if cases of BECTS are present in the North American SUDEP Registry (NASR). Design, Setting, and Participants: The NASR is a clinical and biospecimen repository established in 2011 to promote SUDEP research. The NASR database, which includes medical records, results of electroencephalographic tests, and interviews with family members of patients with epilepsy who died suddenly without other identifiable causes of death, was queried from June 3, 2011, to June 3, 2016, for cases of BECTS. The patients with epilepsy had died suddenly without other identifiable causes of death (eg, drowning, trauma, exposure to toxic substances, or suicide); SUDEP classification was determined by the consensus of 2 epileptologists. Main Outcomes and Measures: Cases of SUDEP among children who received a diagnosis of BECTS among patients reported in the NASR. Results: Three boys (median age at death, 12 years; range, 9-13 years) who received a diagnosis of BECTS by their pediatric epileptologist or neurologists were identified among 189 cases reported in the NASR. The median age of epilepsy onset was 5 years (range, 3-11 years), and the median duration of epilepsy was 4 years (range, 1-10 years). Two deaths were definite SUDEP, and 1 was probable SUDEP. Independent review of clinical and electroencephalographic data supported the diagnosis of BECTS in all 3 patients. None of the patients was prescribed antiseizure drugs, either owing to physician recommendation or mutual decision by the physician and parents. All 3 patients were found dead in circumstances typical of SUDEP. The 3 patients spanned the spectrum of BECTS severity: 1 had only a few seizures, 1 had more than 30 focal motor seizures, and 1 had 4 witnessed generalized tonic-clonic seizures and approximately 30 suspected generalized tonic-clonic seizures. Conclusions and Relevance: Sudden unexpected death in epilepsy is a very rare outcome in BECTS that clinicians should consider discussing in appropriate circumstances and possibly factoring into treatment decisions.
[Mh] Termos MeSH primário: Morte Súbita/epidemiologia
Epilepsia Rolândica/mortalidade
Sistema de Registros/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Criança
Epilepsia Rolândica/epidemiologia
Epilepsia Rolândica/fisiopatologia
Seres Humanos
Masculino
América do Norte/epidemiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1001/jamaneurol.2016.6126


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[PMID]:28351718
[Au] Autor:Xiong W; Zhou D
[Ad] Endereço:Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
[Ti] Título:Progress in unraveling the genetic etiology of rolandic epilepsy.
[So] Source:Seizure;47:99-104, 2017 Apr.
[Is] ISSN:1532-2688
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Rolandic epilepsy (RE), or benign epilepsy of childhood with centrotemporal spikes (BECT), is the most frequent idiopathic partial epilepsy syndrome of childhood, where the "idiopathic" implies a genetic predisposition. Although RE has long been presumed to have a genetic component, clinical and genetic studies have shown a complex inheritance pattern. Furthermore, the underlying major genetic influence in RE has been challenged by recent reports of twin studies. Meanwhile, many genes or loci have been shown to be associated the RE/atypical RE (ARE) spectrum, with a higher frequency of causative variants in ARE. However, a full understanding of the genetic basis in the more common forms of the RE spectrum remains elusive.
[Mh] Termos MeSH primário: Epilepsia Rolândica/genética
[Mh] Termos MeSH secundário: Epilepsia Rolândica/etiologia
Epilepsia Rolândica/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28121917
[Au] Autor:Liu MJ; Su XJ; Md XS; Wu GF; Zhang YQ; Gao L; Wang W; Liao JX; Wang H; Mai JN; Gao JY; Shu XM; Huang SP; Zhang L; Zou LP
[Ad] Endereço:aDepartment of Pediatrics, Chinese PLA General Hospital bCenter of Epilepsy, Beijing Institute for Brain Disorders, Beijing cDepartment of Neurology, Wuhan Children's Hospital Wuhan Shi, Hubei Sheng dDepartment of Neurology, Tianjin Children's Hospital, Tianjin eDepartment of Pediatrics, Henan Province People's Hospital, Henan fDepartment of Neurology, Harbin Children's Hospital, Heilongjiang Sheng gDepartment of Neurology, Shenzhen Children's Hospital, Shenzhen Shi, Guangdong Sheng hDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang Shi, Liaoning Sheng iDepartment of Neurology, Guangzhou Women's and Children's Medical Center, Guangzhou jDepartment of Neurology, Tangshan Women's Children's Hospital, Tangshan Shi, Hebei Sheng kDepartment of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi lDepartment of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an mDepartment of Pediatrics, Linyi People's Hospital, Linyi, China.
[Ti] Título:Clinical features of benign epilepsy of childhood with centrotemporal spikes in chinese children.
[So] Source:Medicine (Baltimore);96(4):e5623, 2017 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This multicenter clinical trial was conducted to examine current practice of benign epilepsy with centrotemporal spikes and especially address the question that in what circumstances 1 antiepileptic drug (AED) should be preferred.Twenty-five medical centers participate in this clinical trial. The general information, clinical information, and treatment status were collected under the guidance of clinicians and then analyzed. Difference between different treatment groups was compared, and usefulness of the most commonly used AEDs was evaluated.A total of 1817 subjects were collected. The average age of the subject was 8.81 years. The average age of onset is 6.85 years (1-14 years). Male-to-female ratio is 1.13:1. A total of 62.9% of the patients are receiving monotherapies, and 10.6% are receiving multidrug therapy. Both age and course of disease of treated rolandic epilepsy (RE) patients are significantly different from those of untreated patients. Bilateral findings on electroencephalography (EEG) are less seen in patients with monotherapy compared with patients with multidrug therapy. Except for 25.4% patients not taking any AEDs, oxcarbazepine (OXC), sodium valproate (VPA), and levetiracetam (LEV) are the most commonly used 3 AEDs. VPA and LEV are commonly used in add-on therapy. OXC and LEV are more effective as monotherapy than VPA.Age of onset of Chinese RE patients is 6.85 years. Bilateral findings on EEG could be a risk factor to require multidrug therapy. In Chinese patients, OXC, VPA, and LEV are most commonly used AEDs as monotherapy and OXC and LEV are more effective than VPA.
[Mh] Termos MeSH primário: Anticonvulsivantes/administração & dosagem
Carbamazepina/análogos & derivados
Epilepsia Rolândica/tratamento farmacológico
Piracetam/análogos & derivados
Ácido Valproico/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Idade de Início
Encéfalo/fisiopatologia
Carbamazepina/administração & dosagem
Criança
Pré-Escolar
China
Quimioterapia Combinada
Eletroencefalografia
Epilepsia Rolândica/fisiopatologia
Feminino
Seres Humanos
Masculino
Piracetam/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anticonvulsants); 230447L0GL (etiracetam); 33CM23913M (Carbamazepine); 614OI1Z5WI (Valproic Acid); VZI5B1W380 (oxcarbazepine); ZH516LNZ10 (Piracetam)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000005623


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[PMID]:28110926
[Au] Autor:Eom TH; Shin JH; Kim YH; Chung SY; Lee IG; Kim JM
[Ad] Endereço:Department of Pediatric Neurology, College of Medicine, The Catholic University of Korea, Banpo-daero 222, Seoul 06591, Republic of Korea.
[Ti] Título:Distributed source localization of interictal spikes in benign childhood epilepsy with centrotemporal spikes: A standardized low-resolution brain electromagnetic tomography (sLORETA) study.
[So] Source:J Clin Neurosci;38:49-54, 2017 Apr.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Benign childhood epilepsy with centrotemporal spikes (BCECTS), also known as Rolandic epilepsy, is the most common benign childhood epilepsy. Centrotemporal spikes are characteristic findings on electroencephalography (EEG). Though the condition is considered benign, many studies have reported some degree of neuropsychological impairment in individuals with BCECTS. There is also growing evidence from neuroimaging studies that BCECTS may affect a larger portion of the brain than originally thought. We performed distributed source localization analysis of interictal spikes in BCECTS. Current-source density (CSD) of the maximal negative peak of the interictal spikes averaged from each of 20 EEG epochs in 11 patients with BCECTS was measured using standardized low-resolution brain electromagnetic tomography (sLORETA). Rolandic area was included in the distribution of the CSD in all of the patients. The significant CSD and its maximal point were distributed in multiple cortical regions over the Rolandic area. It is suggested that the widespread cortical distribution of interictal spikes seen in this study may be associated with atypical presentation and a variety of comorbidities of BCECTS. Our results imply that BCECTS represents a deviation from normal development during a critical period of brain maturation and that children with BECTS might be more likely to need special medical attention.
[Mh] Termos MeSH primário: Córtex Cerebral/diagnóstico por imagem
Córtex Cerebral/fisiopatologia
Eletroencefalografia/métodos
Epilepsia Rolândica/diagnóstico por imagem
Epilepsia Rolândica/fisiopatologia
Magnetoencefalografia/métodos
Tomografia/métodos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE


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[PMID]:27780283
[Au] Autor:Gogou M; Haidopoulou K; Eboriadou M; Pavlou E
[Ad] Endereço:2nd Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, University General Hospital AHEPA, Thessaloniki, Greece.
[Ti] Título:Sleep Disturbances in Children with Rolandic Epilepsy.
[So] Source:Neuropediatrics;48(1):30-35, 2017 Feb.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to investigate through polysomnography sleep quality in children with rolandic epilepsy and compare sleep variables between these children and healthy controls. Our study population included 15 children with rolandic epilepsy and 27 healthy children who underwent overnight polysomnography. Parameters about sleep architecture and sleep respiratory events were recorded and analyzed. The level of statistical significance was set at 0.05. Patients and controls did not differ in basic epidemiological traits. The percentage of sleep stage rapid eye movement was significantly lower in the epilepsy group. Moreover, the mean value of the obstructive apnea index and the obstructive apnea-hypopnea index was significantly higher in children with rolandic epilepsy compared with healthy children. Longest apnea duration and basal Spo during sleep had also the trend to be higher and lower, respectively, in children with epilepsy. Children with rolandic epilepsy exhibit alterations in sleep architecture, as well as in sleep respiratory patterns. Therefore, sleep quality should be routinely considered in the long-term follow-up of these children.
[Mh] Termos MeSH primário: Epilepsia Rolândica/complicações
Transtornos do Sono-Vigília/etiologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Estudos Transversais
Feminino
Hemoglobinas/metabolismo
Seres Humanos
Masculino
Polissonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1593611


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[PMID]:27631414
[Au] Autor:Ji GJ; Yu Y; Miao HH; Wang ZJ; Tang YL; Liao W
[Ad] Endereço:From the Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei, China (G.J.J.); Collaborative Innovation Centre of Neuropsychiatric Disorders and Mental Health, Anhui Province, China (G.J.J.); Department of Psychology, School of Education (G.J.J.,
[Ti] Título:Decreased Network Efficiency in Benign Epilepsy with Centrotemporal Spikes.
[So] Source:Radiology;283(1):186-194, 2017 Apr.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To investigate the functional connectome alterations in benign epilepsy with centrotemporal spikes with respect to the occurrence of interictal epileptic discharges (IEDs) during functional magnetic resonance (MR) imaging. Materials and Methods This prospective study was approved by the local institutional review board and was HIPAA compliant. All participants were consecutively enrolled with written informed consent. Forty-three right-handed patients were classified into IED (n = 20, 13 girls and seven boys; mean age ± standard deviation, 9.00 years ± 1.95) and non-IED (n = 23, 11 girls and 12 boys; mean age, 10.22 years ± 2.13) groups on the basis of electroencephalographic data simultaneously recorded during resting-state functional MR imaging at 3.0 T. The functional connectome features (estimated with graph theoretical analysis) in patient groups and control subjects who were matched for sex, age, and education level (n = 28, all right-handed, 13 girls and 15 boys; mean age, 10.00 years ± 2.31) were compared by using one-way analysis of variance. Results Patients with IEDs and those without IEDs showed consistently abnormal global topology in their functional networks (ie, decreased global efficiency; P < .05) relative to that of control subjects, with no differences between the two patient groups (P > .05). Decreased regional efficiency and connectivity strength were observed in the patients with IEDs and those without (mainly in the perirolandic and frontal areas) relative to control subjects (P < .05). Moreover, the altered functional features significantly correlated with clinical characteristics (ie, disease duration and age at symptom onset, P < .05). Conclusion These findings suggest that decreased global and regional efficiency are prominent functional deficits in children with benign epilepsy with centrotemporal spikes and can be readily identified with resting-state functional MR imaging, irrespective of IEDs. RSNA, 2016 Online supplemental material is available for this article.
[Mh] Termos MeSH primário: Conectoma/métodos
Epilepsia Rolândica/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Córtex Cerebral
Criança
Estudos Transversais
Eletroencefalografia/métodos
Epilepsia Rolândica/diagnóstico
Epilepsia Rolândica/diagnóstico por imagem
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Rede Nervosa/diagnóstico por imagem
Rede Nervosa/fisiopatologia
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2016160422



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