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  1 / 43 MEDLINE  
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[PMID]:28596064
[Au] Autor:Spencer PS; Schmutzhard E; Winkler AS
[Ad] Endereço:Department of Neurology, School of Medicine, and Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA. Electronic address: spencer@ohsu.edu.
[Ti] Título:Nodding Syndrome in the Spotlight - Placing Recent Findings in Perspective.
[So] Source:Trends Parasitol;33(7):490-492, 2017 07.
[Is] ISSN:1471-5007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nodding syndrome (NS) is a debated scientific topic. A recently published study suggests that NS is an autoimmune disorder based on findings of cross-reacting antibodies between neuronal structures and a protein present in Onchocerca volvulus (OV). In our opinion, the proposed causal relationship between OV infection and NS has yet to be demonstrated and, instead, OV infection in NS may be opportunistic.
[Mh] Termos MeSH primário: Síndrome do Cabeceio/etiologia
Síndrome do Cabeceio/imunologia
Oncocercose/complicações
Oncocercose/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Anti-Helmínticos/sangue
Autoanticorpos/sangue
Doenças Autoimunes/sangue
Doenças Autoimunes/diagnóstico
Doenças Autoimunes/parasitologia
Diagnóstico Diferencial
Seres Humanos
Síndrome do Cabeceio/complicações
Síndrome do Cabeceio/diagnóstico
Onchocerca volvulus/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Helminth); 0 (Autoantibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


  2 / 43 MEDLINE  
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[PMID]:28288182
[Au] Autor:Nannyonga B; Sumpter DJ
[Ad] Endereço:Department of Mathematics, School of Physical Sciences College of Natural Sciences, Makerere University, Kampala, Uganda.
[Ti] Título:Modelling optimal allocation of resources in the context of an incurable disease.
[So] Source:PLoS One;12(3):e0172401, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nodding syndrome has affected and led to the deaths of children between the ages of 5 and 15 in Northern Uganda since 2009. There is no reliable explanation of the disease, and currently the only treatment is through a nutritional programme of vitamins, combined with medication to prevent symptoms. In the absence of a proper medical treatment, we develop a dynamic compartmental model to plan the management of the syndrome and to curb its effects. We use incidence data from 2012 and 2013 from Pader, Lamwo and Kitgum regions of Uganda to parameterize the model. The model is then used to look at how to best plan the nutritional programme in terms of first getting children on to the programme through outreach, and then making sure they remain on the programme, through follow-up. For the current outbreak of nodding disease, we estimate that about half of available resources should be put into outreach. We show how to optimize the balance between outreach and follow-up in this particular example, and provide a general methodology for allocating resources in similar situations. Given the uncertainty of parameter estimates in such situations, we perform a robustness analysis to identify the best investment strategy. Our analysis offers a way of using available data to determine the best investment strategy of controlling nodding syndrome.
[Mh] Termos MeSH primário: Alocação de Recursos para a Atenção à Saúde
Modelos Econômicos
Síndrome do Cabeceio/terapia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Surtos de Doenças
Seres Humanos
Síndrome do Cabeceio/epidemiologia
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172401


  3 / 43 MEDLINE  
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[PMID]:28209852
[Au] Autor:Vogel G
[Ti] Título:Parasitic worm may trigger mystery nodding syndrome.
[So] Source:Science;355(6326):678, 2017 Feb 17.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Autoantígenos/imunologia
Autoimunidade
Proteínas do Citoesqueleto/imunologia
Doenças Negligenciadas/complicações
Síndrome do Cabeceio/imunologia
Síndrome do Cabeceio/parasitologia
Oncocercose Ocular/complicações
[Mh] Termos MeSH secundário: Animais
Autoanticorpos/sangue
Criança
Pré-Escolar
Controle de Doenças Transmissíveis
Proteínas de Helminto/imunologia
Seres Humanos
Ivermectina/administração & dosagem
Doenças Negligenciadas/parasitologia
Doenças Negligenciadas/prevenção & controle
Síndrome do Cabeceio/sangue
Onchocerca volvulus/imunologia
Oncocercose Ocular/parasitologia
Oncocercose Ocular/prevenção & controle
Sudão do Sul/epidemiologia
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Autoantigens); 0 (Cytoskeletal Proteins); 0 (Helminth Proteins); 0 (LMOD1 protein, human); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1126/science.355.6326.678


  4 / 43 MEDLINE  
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[PMID]:28182652
[Au] Autor:Föger K; Gora-Stahlberg G; Sejvar J; Ovuga E; Jilek-Aall L; Schmutzhard E; Kaiser C; Winkler AS
[Ad] Endereço:Department of Neurology, Technical University of Munich, Munich, Germany.
[Ti] Título:Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome.
[So] Source:PLoS Negl Trop Dis;11(2):e0005201, 2017 Feb.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nakalanga syndrome is a condition that was described in Uganda and various other African countries decades ago. Its features include growth retardation, physical deformities, endocrine dysfunction, mental impairment, and epilepsy, amongst others. Its cause remains obscure. Nodding syndrome is a neurological disorder with some features in common with Nakalanga syndrome, which has been described mainly in Uganda, South Sudan, and Tanzania. It has been considered an encephalopathy affecting children who, besides head nodding attacks, can also present with stunted growth, delayed puberty, and mental impairment, amongst other symptoms. Despite active research over the last years on the pathogenesis of Nodding syndrome, to date, no convincing single cause of Nodding syndrome has been reported. In this review, by means of a thorough literature search, we compare features of both disorders. We conclude that Nakalanga and Nodding syndromes are closely related and may represent the same condition. Our findings may provide new directions in research on the cause underlying this neurological disorder.
[Mh] Termos MeSH primário: Síndrome do Cabeceio/etiologia
Síndrome do Cabeceio/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Sudão
Tanzânia
Uganda
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005201


  5 / 43 MEDLINE  
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[PMID]:27765294
[Au] Autor:Spencer PS; Mazumder R; Palmer VS; Oregon-Uganda Research Team on Nodding Syndrome
[Ad] Endereço:Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: spencer@ohsu.edu.
[Ti] Título:Response to R. Colebunders: Helminth infections in Nodding syndrome.
[So] Source:J Neurol Sci;372:441, 2017 Jan 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Helmintíase/complicações
Helmintos/patogenicidade
Síndrome do Cabeceio/complicações
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Síndrome do Cabeceio/parasitologia
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 43 MEDLINE  
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[PMID]:27745691
[Au] Autor:Colebunders R; Suykerbuyk P; Jacob ST; van Oijen M
[Ad] Endereço:Global Health Institute, University of Antwerp, Antwerp, Belgium.
[Ti] Título:Nodding syndrome, other forms of epilepsy, and the Nakalanga syndrome most likely directly or indirectly caused by Onchocerca volvulus.
[So] Source:J Neurol Sci;372:439-440, 2017 Jan 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Síndrome do Cabeceio/etiologia
Onchocerca volvulus/patogenicidade
Oncocercose/complicações
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


  7 / 43 MEDLINE  
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[PMID]:27653888
[Au] Autor:Spencer PS; Mazumder R; Palmer VS; Lasarev MR; Stadnik RC; King P; Kabahenda M; Kitara DL; Stadler D; McArdle B; Tumwine JK; other Members of the Oregon-Uganda Nodding Syndrome Research Team
[Ad] Endereço:Global Health Center (former), Oregon Health & Science University, Portland, OR, USA; Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, US
[Ti] Título:Environmental, dietary and case-control study of Nodding Syndrome in Uganda: A post-measles brain disorder triggered by malnutrition?
[So] Source:J Neurol Sci;369:191-203, 2016 Oct 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nodding Syndrome (NS) is an epileptic encephalopathy characterized by involuntary vertical head nodding, other types of seizures, and progressive neurological deficits. The etiology of the east African NS epidemic is unknown. In March 2014, we conducted a case-control study of medical, nutritional and other risk factors associated with NS among children (aged 5-18years) of Kitgum District, northern Uganda (Acholiland). Data on food availability, rainfall, and prevalent disease temporally related to the NS epidemic were also analyzed. In NS Cases, the mean age of reported head nodding onset was 7.6years (range 1-17years). The epidemiologic curve of NS incidence spanned 2000-2013, with peaks in 2003 and 2008. Month of onset of head nodding was non-uniform, with all-year-aggregated peaks in April and June when food availability was low. Families with one or more NS Cases had been significantly more dependent on emergency food and, immediately prior to head nodding onset in the child, subsistence on moldy plant materials, specifically moldy maize. Medical history revealed a single significant association with NS, namely prior measles infection. NS is compared with the post-measles disorder subacute sclerosing panencephalitis, with clinical expression triggered by factors associated with poor nutrition.
[Mh] Termos MeSH primário: Encefalopatias/etiologia
Meio Ambiente
Desnutrição/complicações
Sarampo
Síndrome do Cabeceio/epidemiologia
Síndrome do Cabeceio/etiologia
[Mh] Termos MeSH secundário: Adolescente
Antropometria
Encefalopatias/epidemiologia
Estudos de Casos e Controles
Criança
Dieta/efeitos adversos
Feminino
Seres Humanos
Masculino
Desnutrição/epidemiologia
Inquéritos e Questionários
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


  8 / 43 MEDLINE  
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[PMID]:27642461
[Au] Autor:Obol JH; Arony DA; Wanyama R; Moi KL; Bodo B; Odong PO; Odida M
[Ad] Endereço:Department of Public Health, Faculty of Medicine, Gulu University, P.O Box 166, Gulu.
[Ti] Título:Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda.
[So] Source:Pan Afr Med J;24:123, 2016.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Nodding syndrome was first reported in Uganda in 2003 among internally displaced populations. Risk factors for the syndrome remain unknown. We therefore explored vitamin B6 deficiency and resulting high 3-hydroxykynurenine (3-HK) levels as risk factor for nodding syndrome in Northern Uganda. METHODS: Case-control study conducted in Gulu and Amuru districts. Cases were children/young adults with nodding syndrome. Healthy children/young adults were recruited as controls from same community as cases. Data on socio-demographic and other risk factors was collected using questionnaires. Whole blood was collected in EDTA tubes for assay of 3-HK and vitamin B6 using sandwich ELISA. Conditional logistic regression model was used to assess associations. RESULTS: 66 cases and 73 controls were studied. Factors associated with nodding syndrome were being positive for 3-HK (AOR=4.50, p=0.013), vitamin B6 concentration below mean (AOR=7.22, P=0.001), child being taken care of by mother only (AOR=5.43, p=0.011), child being taken care of by guardian (AOR=5.90, p=0.019) and child consuming relief food at weaning (AOR=4.05, p=0.021). CONCLUSION: Having low vitamin B6 concentration which leads to a build up of 3-hydroxykynurenine concentration in cases as a main risk factor. Therefore, cases should be treated with vitamin B6 and community members should be sensitise to ensure adequate dietary intake of vitamin B6 so that the risk of nodding syndrome among children is averted. We encourage future prospective intervention study to be conducted to assess the effect of low vitamin B6 on the development of nodding syndrome via raised 3-HK concentration.
[Mh] Termos MeSH primário: Cinurenina/análogos & derivados
Síndrome do Cabeceio/sangue
Deficiência de Vitamina B 6/complicações
Vitamina B 6/sangue
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
Pré-Escolar
Feminino
Seres Humanos
Cinurenina/sangue
Modelos Logísticos
Masculino
Síndrome do Cabeceio/etiologia
Fatores de Risco
Inquéritos e Questionários
Uganda
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
27723548JL (3-hydroxykynurenine); 343-65-7 (Kynurenine); 8059-24-3 (Vitamin B 6)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160920
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2016.24.123.8409


  9 / 43 MEDLINE  
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[PMID]:27471850
[Au] Autor:Atim P; Ochola E; Ssendagire S; Rutebemberwa E
[Ad] Endereço:Department of Health Policy, Planning and Management, Makerere University School of Public Health, Kampala, Uganda.
[Ti] Título:Health Seeking Behaviours among Caretakers of Children with Nodding Syndrome in Pader District - Northern Uganda: A Mixed Methods Study.
[So] Source:PLoS One;11(7):e0159549, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nodding syndrome is a neurological disorder which had affected about 3000 children with over 170 deaths in northern Uganda by 2012. With limited data on health seeking, the study aimed to assess the health seeking behavior and associated factors among caretakers of children with nodding syndrome in Pader district. METHODS: A mixed methods cross sectional study was conducted in July 2013 among 249 caretakers of children with nodding syndrome in three sub-counties of Pader. Respondents were consecutively interviewed using semi-structured questionnaires. Eleven key informants were additionally interviewed. We determined the associations of various factors with health care seeking and obtained adjusted odds ratios and 95% confidence intervals using logistic regression model. Quantitative data was analysed using Stata version 12 while qualitative data was analysed manually and quotes reported. RESULTS: Most caretakers, 78.3% (195/249) sought care first from a health facility, 12.9% (32/249) visited traditional healers and 8.8% (22/249) self-medicated. Of those who sought care from a health facility, 50% sought care after a month. Factors associated with improved care seeking included: Time taken to reach care 1-3 hours; adjusted odds ratio = 6.4 (95% CI = 2.96-14.03), time spent in care above five years; adjusted odds ratio = 12.0 (95% CI: 1.24-117.73) and changed care seeking place; adjusted odds ratio = 17.2 (95% CI: 3.64-81.67). CONCLUSION/ RECOMMENDATION: Caretakers sought care from multiple places. One in five caretakers still sought care outside a formal health facility. Many respondents who sought care first from health facilities went late, at least one month after symptoms onset. Factors associated with health seeking included distance, duration in treatment and not having changing care provider. There is need for massive sensitization of community to enhance prompt care seeking. More research is needed to elucidate the cause, thus finding the treatment for nodding syndrome, to prevent "wandering in hope".
[Mh] Termos MeSH primário: Cuidadores
Síndrome do Cabeceio/terapia
Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Estudos Transversais
Seres Humanos
Uganda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0159549


  10 / 43 MEDLINE  
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[PMID]:27444776
[Au] Autor:Nakigudde J; Mutamba BB; Bazeyo W; Musisi S; James O
[Ad] Endereço:Department of Psychiatry, Makerere College of Health Sciences, P.O. Box 7072, Kampala, Uganda. janetnakigudde@gmail.com.
[Ti] Título:An exploration of caregiver burden for children with nodding syndrome (lucluc) in Northern Uganda.
[So] Source:BMC Psychiatry;16:255, 2016 Jul 22.
[Is] ISSN:1471-244X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Caregivers of patients with chronic illnesses are often uncompensated for work that is physically demanding, time consuming and emotionally and economically draining. This is particularly true for caregivers of children with nodding syndrome, an emergent neurological disorder of unknown etiology in resource poor settings in Africa. We aimed to explore perceptions of caregivers regarding challenges that a typical caregiver faces when caring for a child with nodding syndrome. METHODS: We used a qualitative exploratory study design with focus group discussions and in-depth interviews to collect data. We analyzed data using the qualitative analysis software package of NVivo and thematic query building. RESULTS: Emergent themes centered on burden of care with emotional agony as the most prominent. Subthemes reflecting the burden of care giving included child and caregiver safety concerns, burnout, social isolation and rejection, and homicidal ideation. Caregivers also complained of physical and financial constraints associated with the care of children with nodding syndrome. CONCLUSIONS: The findings point to a high burden of care for caregivers of children with nodding syndrome and suggests the need to incorporate community-based psychosocial and mental health care services for the caregivers of affected children into the national health system response.
[Mh] Termos MeSH primário: Adaptação Psicológica
Cuidadores/psicologia
Cuidado da Criança/psicologia
Efeitos Psicossociais da Doença
Síndrome do Cabeceio
[Mh] Termos MeSH secundário: Adulto
Criança
Feminino
Grupos Focais
Seres Humanos
Masculino
Meia-Idade
Pesquisa Qualitativa
Uganda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160723
[St] Status:MEDLINE
[do] DOI:10.1186/s12888-016-0955-x



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