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[PMID]:28334965
[Au] Autor:Vaudano AE; Ruggieri A; Avanzini P; Gessaroli G; Cantalupo G; Coppola A; Sisodiya SM; Meletti S
[Ad] Endereço:Department of Biomedical, Metabolic, and Neural Science, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, OCSE Hospital, Modena, Italy.
[Ti] Título:Photosensitive epilepsy is associated with reduced inhibition of alpha rhythm generating networks.
[So] Source:Brain;140(4):981-997, 2017 Apr 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:See Hamandi (doi:10.1093/awx049) for a scientific commentary on this article.Photosensitivity is a condition in which lights induce epileptiform activities. This abnormal electroencephalographic response has been associated with hyperexcitability of the visuo-motor system. Here, we evaluate if intrinsic dysfunction of this network is present in brain activity at rest, independently of any stimulus and of any paroxysmal electroencephalographic activity. To address this issue, we investigated the haemodynamic correlates of the spontaneous alpha rhythm, which is considered the hallmark of the brain resting state, in photosensitive patients and in people without photosensitivity. Second, we evaluated the whole-brain functional connectivity of the visual thalamic nuclei in the various populations of subjects under investigation. Forty-four patients with epilepsy and 16 healthy control subjects underwent an electroencephalography-correlated functional magnetic resonance imaging study, during an eyes-closed condition. The following patient groups were included: (i) genetic generalized epilepsy with photosensitivity, 16 subjects (mean age 25 ± 10 years); (ii) genetic generalized epilepsy without photosensitivity, 13 patients (mean age 25 ± 11 years); (iii) focal epilepsy, 15 patients (mean age 25 ± 9 years). For each subject, the posterior alpha power variations were convolved with the standard haemodynamic response function and used as a regressor. Within- and between-groups second level analyses were performed. Whole brain functional connectivity was evaluated for two thalamic regions of interest, based on the haemodynamic findings, which included the posterior thalamus (pulvinar) and the medio-dorsal thalamic nuclei. Genetic generalized epilepsy with photosensitivity demonstrated significantly greater mean alpha-power with respect to controls and other epilepsy groups. In photosensitive epilepsy, alpha-related blood oxygen level-dependent signal changes demonstrated lower decreases relative to all other groups in the occipital, sensory-motor, anterior cingulate and supplementary motor cortices. Coherently, the same brain regions demonstrated abnormal connectivity with the visual thalamus only in epilepsy patients with photosensitivity. As predicted, our findings indicate that the cortical-subcortical network generating the alpha oscillation at rest is different in people with epilepsy and visual sensitivity. This difference consists of a decreased alpha-related inhibition of the visual cortex and sensory-motor networks at rest. These findings represent the substrate of the clinical manifestations (i.e. myoclonus) of the photoparoxysmal response. Moreover, our results provide the first evidence of the existence of a functional link between the circuits that trigger the visual sensitivity phenomenon and those that generate the posterior alpha rhythm.
[Mh] Termos MeSH primário: Ritmo alfa
Epilepsia Reflexa/fisiopatologia
Rede Nervosa/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ritmo alfa/genética
Encéfalo/diagnóstico por imagem
Encéfalo/fisiopatologia
Eletroencefalografia
Epilepsias Parciais/diagnóstico por imagem
Epilepsias Parciais/fisiopatologia
Epilepsia Generalizada/diagnóstico por imagem
Epilepsia Generalizada/fisiopatologia
Epilepsia Reflexa/diagnóstico por imagem
Epilepsia Reflexa/genética
Feminino
Hemodinâmica
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Rede Nervosa/diagnóstico por imagem
Oxigênio/sangue
Descanso
Estudos Retrospectivos
Núcleos Talâmicos/diagnóstico por imagem
Núcleos Talâmicos/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx009


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[PMID]:28273589
[Au] Autor:Brna PM; Gordon KG
[Ad] Endereço:Department of Pediatrics, Dalhousie University, Canada. Electronic address: pbrna@dal.ca.
[Ti] Título:"Selfie-epilepsy": A novel photosensitivity.
[So] Source:Seizure;47:5-8, 2017 Apr.
[Is] ISSN:1532-2688
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Photosensitivity is a well-described phenomenon; affecting a relatively small proportion of individuals with epilepsy. Typically people with photosensitive epilepsies are at risk of seizures induced by shimmering natural light, strobe lights and with particular patterns or flicker frequencies on television and video games. METHODS & RESULTS: We present a novel case of photosensitivity captured during video EEG monitoring showing reproducible photosensitivity with the ever-popular social phenomenon; the "selfie." The patient had previously demonstrated photosensitive myoclonus with intermittent photic stimulation on routine EEG. CONCLUSION: This case suggests that taking "selfies" may represent a new area of caution for those with photosensitive epilepsies.
[Mh] Termos MeSH primário: Encéfalo/fisiopatologia
Epilepsia Reflexa/fisiopatologia
Fotografia
Smartphone
[Mh] Termos MeSH secundário: Adolescente
Diagnóstico Diferencial
Eletroencefalografia
Epilepsia Reflexa/diagnóstico
Seres Humanos
Estimulação Luminosa/efeitos adversos
Comportamento Social
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE


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[PMID]:28215998
[Au] Autor:Poleon S; Szaflarski JP
[Ad] Endereço:University of Alabama at Birmingham, Department of Neurology and UAB Epilepsy Center, Birmingham, AL, USA. Electronic address: shrvon17@uab.edu.
[Ti] Título:Photosensitivity in generalized epilepsies.
[So] Source:Epilepsy Behav;68:225-233, 2017 Mar.
[Is] ISSN:1525-5069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Photosensitivity, which is the hallmark of photosensitive epilepsy (PSE), is described as an abnormal EEG response to visual stimuli known as a photoparoxysmal response (PPR). The PPR is a well-recognized phenomenon, occurring in 2-14% of patients with epilepsy but its pathophysiology is not clearly understood. PPR is electrographically described as 2-5Hz spike, spike-wave, or slow wave complexes with frontal and paracentral prevalence. Diagnosis of PPR is confirmed using intermittent photic stimulation (IPS) as well as video monitoring. The PPR can be elicited by certain types of visual stimuli including flicker, high contrast gratings, moving patterns, and rapidly modulating luminance patterns which may be encountered during e.g., watching television, playing video games, or attending discotheques. Photosensitivity may present in different idiopathic (genetic) epilepsy syndromes e.g. juvenile myoclonic epilepsy (JME) as well as non-IGE syndromes e.g. severe myoclonic epilepsy of infancy. Consequently, PPR is present in patients with diverse seizure types including absence, myoclonic, and generalized tonic-clonic (GTC) seizures. Across syndromes, abnormalities in structural connectivity, functional connectivity, cortical excitability, cortical morphology, and behavioral and neuropsychological function have been reported. Treatment of photosensitivity includes antiepileptic drug administration, and the use of non-pharmacological agents, e.g. tinted or polarizing glasses, as well as occupational measures, e.g. avoidance of certain stimuli.
[Mh] Termos MeSH primário: Anticonvulsivantes/uso terapêutico
Epilepsia Generalizada/diagnóstico
Epilepsia Reflexa/diagnóstico
Estimulação Luminosa
[Mh] Termos MeSH secundário: Eletroencefalografia
Epilepsia Generalizada/tratamento farmacológico
Epilepsia Generalizada/fisiopatologia
Epilepsia Reflexa/tratamento farmacológico
Epilepsia Reflexa/fisiopatologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28135595
[Au] Autor:Sarkisova KY; Fedotova IB; Surina NM; Nikolaev GM; Perepelkina OV; Kostina ZA; Poletaeva II
[Ad] Endereço:Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia. Electronic address: karine.online@yandex.ru.
[Ti] Título:Genetic background contributes to the co-morbidity of anxiety and depression with audiogenic seizure propensity and responses to fluoxetine treatment.
[So] Source:Epilepsy Behav;68:95-102, 2017 Mar.
[Is] ISSN:1525-5069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Anxiety and depression are the most frequent comorbidities of different types of convulsive and non-convulsive epilepsies. Increased anxiety and depression-like phenotype have been described in the genetic absence epilepsy models as well as in models of limbic epilepsy and acquired seizure models, suggesting a neurobiological connection. However, whether anxiety and/or depression are comorbid to audiogenic epilepsy remains unclear. The aim of this study was to investigate whether anxiety or depression-like behavior can be found in rat strains with different susceptibility to audiogenic seizures (AS) and whether chronic fluoxetine treatment affects this co-morbidity. METHODS: Behavior in the elevated plus-maze and the forced swimming test was studied in four strains: Wistar rats non-susceptible to AS; Krushinsky-Molodkina (KM) strain, selectively bred for AS propensity from outbred Wistar rats; and a selection lines bred for maximal AS expression (strain "4") and for a lack of AS (strain "0") from KM×Wistar F2 hybrids. Effects of chronic antidepressant treatment on AS and behavior were also evaluated. RESULTS: Anxiety and depression levels were higher in KM rats (with AS) compared with Wistar rats (without AS), indicating the comorbidity with AS. However, in strains "4" and "0" with contrasting AS expression, but with a genetic background close to KM rats, anxiety and depression were not as divergent as in KMs versus Wistars. Fluoxetine treatment exerted an antidepressant effect in all rat strains irrespective of its effect on AS. CONCLUSIONS: Genetic background contributes substantively to the co-morbidity of anxiety and depression with AS propensity.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Ansiedade/genética
Depressão/genética
Epilepsia Reflexa/genética
Fluoxetina/uso terapêutico
Patrimônio Genético
Convulsões/genética
[Mh] Termos MeSH secundário: Animais
Ansiedade/complicações
Depressão/complicações
Modelos Animais de Doenças
Epilepsia Reflexa/complicações
Masculino
Ratos
Ratos Wistar
Convulsões/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 01K63SUP8D (Fluoxetine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


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[PMID]:28114705
[Au] Autor:Kobayashi Y; Ishikawa N; Tani H; Fujii Y; Kobayashi M
[Ad] Endereço:Department of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan.
[Ti] Título:Recurrence of Epileptic Spasms as Reflex Seizures Induced by Eating: A Case Report and Literature Review.
[So] Source:Neuropediatrics;48(2):119-122, 2017 Apr.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Eating epilepsy (EE) is a rare form of reflex epilepsy in which seizures are induced by eating. It is known that most patients with eating seizures, in fact, suffer from symptomatic temporal lobe epilepsy (TLE), whereas only a few patients with epileptic spasms induced by eating (E-ES) have been reported. The patient was an 8-year-old girl whose magnetic resonance imaging (MRI) of the head detected dysgenesis of the corpus callosum, cerebellar hypogenesis, marked cerebral asymmetry, broad polymicrogyria, periventricular heterotopia, and closed lip-type schizencephaly. She experienced E-ES as the second form of recurrent seizures after the first recurrence of spontaneous ES. After E-ES occurred, the EEG findings in the right hemisphere, predominantly over the right centrotemporal region, were clearly exacerbated, although the interictal EEG originally showed left-side-dominant asymmetric hypsarrhythmia. The ictal EEG of the E-ES showed diffuse large triphasic (negative-positive-negative) potentials, predominantly over the right centrotemporoparietal region. This is a unique case because the E-ES were recurrent ES, although the previous ES were spontaneous, which may provide insight into the mechanism of E-ES.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Encéfalo/fisiopatologia
Epilepsia Reflexa/diagnóstico por imagem
Epilepsia Reflexa/fisiopatologia
[Mh] Termos MeSH secundário: Anticonvulsivantes/uso terapêutico
Encéfalo/efeitos dos fármacos
Criança
Epilepsia Reflexa/tratamento farmacológico
Feminino
Seres Humanos
Recidiva
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.1055/s-0037-1598111


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[PMID]:28042998
[Au] Autor:Verbeek N; Kasteleijn-Nolst Trenité D; Wassenaar M; van Campen J; Sonsma A; Gunning WB; de Weerd A; Knoers N; Spetgens W; Gutter T; Leijten F; Brilstra E
[Ad] Endereço:Department of Genetics, University Medical Center Utrecht, The Netherlands.
[Ti] Título:Photosensitivity in Dravet syndrome is under-recognized and related to prognosis.
[So] Source:Clin Neurophysiol;128(2):323-330, 2017 Feb.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To detect determinants for photoparoxysmal EEG response (PPR) in SCN1A-related Dravet syndrome (DS). METHODS: Data were studied from nationwide medical histories and EEGs of DS-patients (n=53; 31 males, age 2-19years). Detailed questionnaires on visual stimuli were completed by parents (n=49). RESULTS: PPR was found in 22 patients (42%; median age 1.25yr), and repeatedly in 17%. PPR (17% of 249 intermittent photic stimulation (IPS)-EEGs) occurred more often with optimal IPS protocols (OR 2.11 [95%CI 1.09-4.13]) and in EEGs showing spontaneous epileptiform abnormalities (OR 5.08 [95%CI 2.05-12.55]). PPR-positive patients tended to be younger at first (p=0.072) and second seizure (p=0.049), showed severe intellectual disability (p=0.042), and had more often spontaneous occipital epileptiform abnormalities (p<0.001). Clinical sensitivity was reported in medical files in 22% of patients and by parents in 43% (self-induction 24%). Clinical or EEG proven visual sensitivity was detected in 65% of cases. CONCLUSIONS: Sensitivity to visual stimuli is very common in DS and more often noticed by parents than confirmed by EEG. Detection of PPR improves with repetitive tests using accurate IPS protocols. SIGNIFICANCE: Photosensitivity is an important feature in DS and seems to be a marker of the severity of the disorder. Therefore repeated standardized IPS should be encouraged.
[Mh] Termos MeSH primário: Epilepsias Mioclônicas/diagnóstico
Epilepsia Reflexa/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Eletroencefalografia
Epilepsias Mioclônicas/complicações
Epilepsias Mioclônicas/genética
Epilepsias Mioclônicas/fisiopatologia
Epilepsia Reflexa/epidemiologia
Epilepsia Reflexa/fisiopatologia
Feminino
Seres Humanos
Lactente
Masculino
Canal de Sódio Disparado por Voltagem NAV1.1/genética
Estimulação Luminosa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NAV1.1 Voltage-Gated Sodium Channel); 0 (SCN1A protein, human)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:28001116
[Au] Autor:Shell L; Scariano R; Rishniw M
[Ti] Título:Features of stimulus-specific seizures in dogs with reflex epilepsy: 43 cases (2000-2014).
[So] Source:J Am Vet Med Assoc;250(1):75-78, 2017 Jan 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To describe the occurrence and management of reflex epilepsy (ie, seizure activity triggered by exposure to specific locations or situations) in dogs. DESIGN Retrospective case series. ANIMALS 43 client-owned dogs. PROCEDURES Discussions by veterinarians participating in the Veterinary Information Network online community for the years 2000 through 2014 were reviewed to identify dogs with a diagnosis of reflex epilepsy and seizure activity in response to stimuli. History, signalment (including age at onset), the specific stimulus or stimuli that provoked seizures, treatments, and any concurrent neurologic diagnoses were recorded. RESULTS A variety of breeds were affected. Median age at onset was 5 years (range, 3 months to 11 years). Reflex seizures were reported as being repeatedly triggered by visits to a veterinary clinic (35/43 dogs), grooming facility (24/43 dogs), or boarding facility (13/43 dogs) and, less commonly, by other situations (eg, pet store or car ride). Over half of the dogs (24/43) had multiple triggers. Eight (19%) dogs had seizures at other times that were not induced by location or a specific situation. A variety of sedatives and maintenance antiepileptic drugs administered to affected dogs failed to prevent the stimulus-specific seizure activity. CONCLUSIONS AND CLINICAL RELEVANCE Results of the present study suggested that seizures provoked by specific situations or locations occur in dogs with reflex epilepsy and that common triggers were visits to veterinary and grooming facilities. Further studies are necessary to elucidate the characteristics of reflex epilepsy in dogs and to determine the most effective means to manage these patients.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Epilepsia Reflexa/veterinária
[Mh] Termos MeSH secundário: Animais
Anticonvulsivantes/uso terapêutico
Doenças do Cão/tratamento farmacológico
Cães
Epilepsia Reflexa/tratamento farmacológico
Epilepsia Reflexa/patologia
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.1.75


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[PMID]:27912171
[Au] Autor:Bauer PR; Gorgels K; Spetgens W; van Klink NE; Leijten FS; Sander JW; Visser GH; Zijlmans M
[Ad] Endereço:Stichting Epilepsie Instellingen Nederland (SEIN), Achterweg 5, 2103 SW Heemstede, The Netherlands; Stichting Epilepsie Instellingen Nederland (SEIN), Dr. Denekampweg 20, 8025 BV Zwolle, The Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Institute of Neurology,
[Ti] Título:The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity.
[So] Source:Clin Neurophysiol;128(1):176-182, 2017 Jan.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Up to 30% of people with juvenile myoclonic epilepsy (JME) have photoparoxysmal responses (PPR). Recent studies report on structural and pathophysiological differences between people with JME with (JME+PPR) and without PPR (JME-PPR). We investigated whether electrophysiological features outside photic stimulation differ between these subtypes. METHODS: We analysed EEG recordings of people with JME at a tertiary epilepsy centre and an academic hospital. Photosensitivity was assessed in a drug-naïve condition. We compared the occurrence and involvement of posterior electrodes for focal abnormalities and generalised spike-wave activity in the EEG outside photic stimulation between JME+PPR and JME-PPR. RESULTS: We included EEG recordings of 18 people with JME+PPR and 21 with JME-PPR. People with JME-PPR had less focal abnormalities in the posterior brain regions than people with JME+PPR (19% vs 55%, p<0.05). There was no difference in the distribution of generalised spike-wave activity between people with JME+PPR and JME-PPR. CONCLUSION: This study demonstrates electrophysiological correlates of the previously described structural and physiological differences between JME+PPR and JME-PPR. SIGNIFICANCE: Findings support the hypothesis that posterior interictal EEG abnormalities reflect localised cortical hyperexcitability, which makes patients with JME more sensitive to photic stimuli.
[Mh] Termos MeSH primário: Potenciais de Ação
Mapeamento Encefálico/métodos
Eletroencefalografia/métodos
Epilepsia Reflexa/fisiopatologia
Epilepsia Mioclônica Juvenil/fisiopatologia
Estimulação Luminosa/métodos
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adolescente
Adulto
Criança
Epilepsia Reflexa/diagnóstico
Feminino
Seres Humanos
Masculino
Epilepsia Mioclônica Juvenil/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:27903764
[Au] Autor:Maguire M
[Ti] Título:Epilepsy and music: practical notes.
[So] Source:Pract Neurol;17(2):86-95, 2017 Apr.
[Is] ISSN:1474-7766
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Music processing occurs via a complex network of activity far beyond the auditory cortices. This network may become sensitised to music or may be recruited as part of a temporal lobe seizure, manifesting as either musicogenic epilepsy or ictal musical phenomena. The idea that sound waves may directly affect brain waves has led researchers to explore music as therapy for epilepsy. There is limited and low quality evidence of an antiepileptic effect with the Mozart Sonata K.448. We do not have a pathophysiological explanation for the apparent dichotomous effect of music on seizures. However, clinicians should consider musicality when treating patients with antiepileptic medication or preparing patients for epilepsy surgery. Carbamazepine and oxcarbazepine each may cause a reversible altered appreciation of pitch. Surgical cohort studies suggest that musical memory and perception may be affected, particularly following right temporal lobe surgery, and discussion of this risk should form part of presurgical counselling.
[Mh] Termos MeSH primário: Epilepsia Reflexa/terapia
Epilepsia/terapia
Musicoterapia/métodos
Música
[Mh] Termos MeSH secundário: Anticonvulsivantes/uso terapêutico
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE
[do] DOI:10.1136/practneurol-2016-001487


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[PMID]:27170668
[Au] Autor:Kiziltan ME; Gündüz A; Coskun T; Delil S; Pazarci N; Özkara Ç; Yeni N
[Ad] Endereço:1 Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.
[Ti] Título:Startle Response in Progressive Myoclonic Epilepsy.
[So] Source:Clin EEG Neurosci;48(2):123-129, 2017 Mar.
[Is] ISSN:2169-5202
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cortical reflex myoclonus is a typical feature of progressive myoclonic epilepsy (PME) in which it is accompanied by other types of mostly drug-resistant seizures and progressive neurological signs. Although PME is characterized by cortical hyperexcitability, studies have demonstrated atrophy and degenerative changes in the brainstem in various types of PME. Thus, we have questioned whether any stimuli may trigger a hyperactive response of brainstem reticular formation in PME and investigated the startle reflex in individuals with PME. We recorded the auditory startle response (ASR) and the startle response to somatosensory inputs (SSS) in patients with PME, and compared the results with healthy volunteers and patients with other types of drug-resistant epilepsy. All patients were using antiepileptic drugs (AEDs), 12 were on multiple AEDs. The probability of ASR was significantly lower and mean onset latency was longer in patients with PME compared with other groups. SSS responses over all muscles were low in both the PME and drug-resistant epilepsy groups; however, the differences were not statistically significant. The presence of a response over the biceps brachii muscle was zero in the PME group and showed a borderline difference compared with the other groups. Decreased probability and prolonged latencies of ASR in PME indicate inhibition of reflex circuit. A trend for decreased responses of SSS suggests hypoactive SSS in both PME and other epilepsy groups. Hypoactive ASR in PME and hypoactive SSS in both PME and other epilepsies may be attributed to the degeneration of pontine reticular nuclei in PME and functional inhibition by AEDs in both disorders.
[Mh] Termos MeSH primário: Estimulação Acústica/métodos
Epilepsia Reflexa/fisiopatologia
Epilepsias Mioclônicas Progressivas/fisiopatologia
Inibição Neural
Tempo de Reação
Reflexo de Sobressalto
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160513
[St] Status:MEDLINE
[do] DOI:10.1177/1550059416646292



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