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Pesquisa : C10.228.140.546.399.750.250 [Categoria DeCS]
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  1 / 1616 MEDLINE  
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[PMID]:29371217
[Au] Autor:Jarvis S; Dassan P; Piercy CN
[Ad] Endereço:Imperial College Healthcare NHS Trust, London W12 0HS, UK sheba.jarvis@imperial.ac.uk.
[Ti] Título:Managing migraine in pregnancy.
[So] Source:BMJ;360:k80, 2018 01 25.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Enxaqueca com Aura/tratamento farmacológico
Complicações na Gravidez/tratamento farmacológico
[Mh] Termos MeSH secundário: Acetaminofen/uso terapêutico
Adulto
Analgésicos não Entorpecentes/uso terapêutico
Antieméticos/uso terapêutico
Feminino
Seres Humanos
Gravidez
Sumatriptana/uso terapêutico
Vasoconstritores/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Antiemetics); 0 (Vasoconstrictor Agents); 362O9ITL9D (Acetaminophen); 8R78F6L9VO (Sumatriptan)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k80


  2 / 1616 MEDLINE  
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[PMID]:29384561
[Au] Autor:Gray IN; Cristancho AG; Licht DJ; Liu GT
[Ti] Título:Ocular Dipping in a Patient With Hemiplegic Migraine.
[So] Source:J Pediatr Ophthalmol Strabismus;55:e4-e6, 2018 Jan 31.
[Is] ISSN:1938-2405
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 5-year-old girl presented with acute, rapidly progressive encephalopathy following minor head trauma and was found to have ocular dipping. Her encephalopathy was secondary to a channelopathy caused by a CACNA1A mutation. This is the first reported case of ocular dipping in an encephalopathic child with CACNA1A-confirmed hemiplegic migraine. [J Pediatr Ophthalmol Strabismus. 2018;55:e4-e6.].
[Mh] Termos MeSH primário: Córtex Cerebral/diagnóstico por imagem
Movimentos Oculares/fisiologia
Hemiplegia/complicações
Enxaqueca com Aura/complicações
Nistagmo Patológico/etiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Hemiplegia/diagnóstico
Seres Humanos
Imagem por Ressonância Magnética
Enxaqueca com Aura/diagnóstico
Nistagmo Patológico/diagnóstico
Nistagmo Patológico/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.3928/01913913-20171129-01


  3 / 1616 MEDLINE  
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[PMID]:29357368
[Au] Autor:Yuasa N; Nagata E; Fujii N; Ito M; Tsukamoto H; Takizawa S
[Ad] Endereço:Division of Neurology, Department of Internal Medicine, Isehara Kyodo Hospital, Isehara, Japan.
[Ti] Título:Serum apolipoprotein E may be a novel biomarker of migraine.
[So] Source:PLoS One;13(1):e0190620, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Migraine attacks alter various molecules that might be related to the pathophysiology of migraine, such as serotonin, calcitonin gene-related peptide, and nitric oxide. The underlying pathophysiology of migraine is as yet unclear. We explored key proteins related to the pathogenesis of migraine here. Serum was collected from two patients with migraine with aura (MA) and seven patients with migraine without aura (MO) during attack-free periods and migraine attacks. Samples were analyzed using 2-dimensional gel electrophoresis. Nineteen protein spots were altered between the attack-free versus migraine attack periods. Mass spectrometric analysis was performed to identify the proteins within each of the 19 altered spots. Thirty-six proteins were significantly altered in samples collected during attack-free periods versus migraine attacks. The protein with the statistically most significant MASCOT/Mowse score (268±112) among lipoproteins was apolipoprotein (ApoE). In the MA and MO groups, ApoE protein levels were significantly higher during migraine attack than during the attack-free period (p<0.05). ApoE protein levels were also significantly increased in the MA group during the attack-free period compared to healthy controls and patients with tension type headaches (p<0.01). Migraine alters ApoE levels, especially in MA. ApoE might play an important role in the pathophysiology of migraine, and may act as a diagnostic biomarker of migraine.
[Mh] Termos MeSH primário: Apolipoproteínas E/sangue
Biomarcadores/sangue
Enxaqueca com Aura/sangue
Enxaqueca sem Aura/sangue
[Mh] Termos MeSH secundário: Adulto
Eletroforese em Gel Bidimensional
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Meia-Idade
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190620


  4 / 1616 MEDLINE  
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[PMID]:28747203
[Au] Autor:Shi YJ; Lv J; Han XT; Luo GG
[Ad] Endereço:Department of Neurology, Xi'an Jiaotong University, Xi'an, China.
[Ti] Título:Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis.
[So] Source:BMC Cardiovasc Disord;17(1):203, 2017 07 26.
[Is] ISSN:1471-2261
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The association between patent foramen ovale (PFO) and migraine with aura (MA) is well established. However, the benefits of PFO closure are less certain in patients with migraine without aura (MwoA). METHODS: We systematically searched Pubmed for pertinent clinical studies published from January 2000 to July 2015. The primary end-point was the elimination or significant improvement of migraine symptoms after PFO closure. RESULTS: Upon screening an initial list of 315 publications, we identified eight studies that included 546 patients. Overall, our analysis indicated a significant improvement of migraine in 81% of MA cases compared to only 63% of MwoA cases. The summary odds ratio was 2.5 (95% confidence interval 1.09-5.73), and the benefits of PFO closure were significantly greater for patients with MA compared to patients with MwoA (P = 0.03). CONCLUSIONS: The presence of aura provides a reference standard for the clinical selection of patients with migraine for PFO closure intervention.
[Mh] Termos MeSH primário: Cateterismo Cardíaco
Forame Oval Patente/terapia
Enxaqueca com Aura/prevenção & controle
Enxaqueca sem Aura/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Distribuição de Qui-Quadrado
Feminino
Forame Oval Patente/complicações
Forame Oval Patente/diagnóstico
Forame Oval Patente/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Enxaqueca com Aura/diagnóstico
Enxaqueca com Aura/etiologia
Enxaqueca sem Aura/diagnóstico
Enxaqueca sem Aura/etiologia
Razão de Chances
Seleção de Pacientes
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12872-017-0644-9


  5 / 1616 MEDLINE  
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[PMID]:27774589
[Au] Autor:Calhoun AH
[Ad] Endereço:Carolina Headache Institute, Durham, NC, USA.
[Ti] Título:Hormonal Contraceptives and Migraine With Aura-Is There Still a Risk?
[So] Source:Headache;57(2):184-193, 2017 Feb.
[Is] ISSN:1526-4610
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Unnecessary confusion still surrounds the use of combined hormonal contraceptives (CHCs) in the setting of migraine with aura (MwA). Clearing this confusion is a key issue for headache specialists, since most women with migraine have menstrual-related migraine (MRM), and some CHCs can prevent this particularly severe migraine. Their use, however, is still restricted by current guidelines due to concerns of increased stroke risk - concerns that originated over half a century ago in the era of high dose contraceptives. Yet studies consistently show that stroke risk is not increased with today's very low dose CHCs containing 20-25 µg ethinyl estradiol (EE), and continuous ultra low-dose formulations (10-15 µg EE) may even reduce aura frequency, thereby potentially decreasing stroke risk. This article clarifies the stroke risk of CHCs and examines their impact on migraine. It also examines how stroke risk is altered by the estrogen content of the CHC, by contributing factors such as smoking, age and hypertension, and by aura frequency. And finally, it puts these risks into a meaningful context with a risk/benefit assessment.
[Mh] Termos MeSH primário: Anticoncepcionais Orais Hormonais/efeitos adversos
Enxaqueca com Aura/epidemiologia
Acidente Vascular Cerebral/epidemiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contraceptives, Oral, Hormonal)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/head.12960


  6 / 1616 MEDLINE  
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[PMID]:29059314
[Au] Autor:Chang MY; Phasukkijwatana N; Garrity S; Pineles SL; Rahimi M; Sarraf D; Johnston M; Charles A; Arnold AC
[Ad] Endereço:Stein Eye Institute, University of California, Los Angeles, California, United States.
[Ti] Título:Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5477-5484, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Migraine, particularly with aura, has been associated with ocular and systemic ischemic complications, but there are limited data on the ocular vasculature in migraine. We used optical coherence tomography angiography (OCTA) to assess perfusion of the macula and optic nerve in migraine patients, with (MA) and without (MO) aura, compared to healthy controls (HC). Methods: We recruited 15 MA (mean age 42 years), 12 MO (mean age 46 years), and 22 HC (mean age 39 years) participants from neurology and neuro-ophthalmology clinics. Participants underwent optical coherence tomography and 3 × 3 mm OCTA of the macula and optic nerve. Foveal avascular zone area was automatically measured using AngioVue software, and vessel density was calculated as blood vessel length divided by scan area (mm-1) after skeletonization of OCTA images. Results: On macular OCTA, MA participants had an enlarged foveal avascular zone area when compared with HC (0.300 ± 0.019 vs. 0.220 ± 0.066 mm2, P = 0.006). In addition, superficial foveal vessel density was decreased in MA participants when compared with MO participants (7.8 ± 0.31 vs. 9.3 ± 0.44, P = 0.04) and HC (7.8 ± 0.31 vs. 9.4 ± 0.21 mm-1, P = 0.002). On optic nerve OCTA, the MA participants had reduced superior peripapillary vessel density when compared with the MO participants (12.0 ± 0.45 vs. 14.0 ± 0.38 mm-1, P = 0.031) and HC (12.0 ± 0.45 vs. 14.1 ± 0.53 mm-1, P = 0.035). There were no significant differences between the MO and HC groups. Conclusions: Migraine with, but not without, aura was associated with foveal and peripapillary vascular decrements, which may possibly mediate increased risk of ocular and systemic vascular complications in these patients. OCTA could potentially be useful as a biomarker for migraine with aura.
[Mh] Termos MeSH primário: Fóvea Central/irrigação sanguínea
Enxaqueca com Aura/fisiopatologia
Enxaqueca sem Aura/fisiopatologia
Disco Óptico/irrigação sanguínea
[Mh] Termos MeSH secundário: Adolescente
Adulto
Angiografia por Tomografia Computadorizada
Feminino
Fóvea Central/diagnóstico por imagem
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Disco Óptico/diagnóstico por imagem
Tomografia de Coerência Óptica/métodos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22477


  7 / 1616 MEDLINE  
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[PMID]:28682918
[Au] Autor:Xu JH; Mi HY
[Ad] Endereço:Department of Neurology, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China.
[Ti] Título:A randomized controlled trial of acupressure as an adjunctive therapy to sodium valproate on the prevention of chronic migraine with aura.
[So] Source:Medicine (Baltimore);96(27):e7477, 2017 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The primary objective of the present study was to evaluate the efficacy and safety of using acupressure as an adjunctive therapy to sodium valproate (SV) combined with acupressure (ASV) on the prevention of chronic migraine with aura (CMA). METHODS: A total of 98 patients with CMA were randomly divided into an intervention group and a control group, with 49 patients in each group. The patients in the intervention group received ASV, while the participants in the control group received SV alone. The primary outcome was measured by the numeric rating scale (NRS). The secondary outcomes including frequency of migraine attacks, the times of using analgesics, and quality of life, measured by the short-form 36 Health Survey Scale (SF-36) score. In addition, adverse events (AEs) were also recorded throughout the trial. The outcomes were measured at the end of the 8-week treatment, and 4-week follow-up. RESULTS: After the 8-week treatment and 4-week follow-up, ASV efficacy was not greater than that of SV alone regarding pain relief, as measured using the NRS, and frequency of migraine attacks, consumption of analgesics, and quality of life, as measured using the SF-36. However, ASV can significantly reduce the nausea when compared with SV (P = .04). CONCLUSION: The present results indicate that ASV can decrease migraine-related nausea during treatment, but cannot relieve pain or enhance quality of life in patients with CMA.
[Mh] Termos MeSH primário: Acupressão
Fármacos do Sistema Nervoso Central/uso terapêutico
Enxaqueca com Aura/terapia
Ácido Valproico/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Analgésicos/uso terapêutico
Terapia Combinada
Feminino
Seguimentos
Seres Humanos
Masculino
Medição da Dor
Qualidade de Vida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics); 0 (Central Nervous System Agents); 614OI1Z5WI (Valproic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007477


  8 / 1616 MEDLINE  
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[PMID]:28656458
[Au] Autor:Pisanu C; Preisig M; Castelao E; Glaus J; Pistis G; Squassina A; Del Zompo M; Merikangas KR; Waeber G; Vollenweider P; Mwinyi J; Schiöth HB
[Ad] Endereço:Division of Functional Pharmacology, Department of Neuroscience, BMC, University of Uppsala, Husargatan 3, 75124, Uppsala, Sweden.
[Ti] Título:A genetic risk score is differentially associated with migraine with and without aura.
[So] Source:Hum Genet;136(8):999-1008, 2017 08.
[Is] ISSN:1432-1203
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Although a number of migraine-associated single-nucleotide polymorphisms (SNP) with small effect size have been identified, little is known about the additive impact of these variants on migraine risk, frequency and severity. We investigated to what extent a genetic risk score (GRS) based on recently published, novel migraine-associated SNPs is associated with migraine prevalence, subtypes and severity in a large population-based sample. The sample comprised 446 subjects with migraine and 2511 controls from the CoLaus/PsyCoLaus study. Fifty-four SNPs earlier associated with migraine were selected. SNPs with a low impact on migraine prevalence in our sample were excluded using random forest. We combined the remaining 21 SNPs into a GRS and analyzed the association with migraine using logistic regression models. The GRS was significantly associated with migraine (OR = 1.56, p = 0.02) and migraine without aura (MWOA) (OR = 2.01, p = 0.003), but not with migraine with aura (MWA). The GRS was not associated with migraine frequency, intensity or interference with daily activities. We show that a GRS combining multiple genetic risk variants is associated with MWOA but not MWA, suggesting a different genetic susceptibility background underlying the two forms of migraine.
[Mh] Termos MeSH primário: Enxaqueca com Aura/genética
Enxaqueca sem Aura/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Estudos de Coortes
Feminino
Loci Gênicos
Técnicas de Genotipagem
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Prevalência
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1007/s00439-017-1816-5


  9 / 1616 MEDLINE  
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[PMID]:28430860
[Au] Autor:Hougaard A; Amin FM; Christensen CE; Younis S; Wolfram F; Cramer SP; Larsson HBW; Ashina M
[Ad] Endereço:Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
[Ti] Título:Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura.
[So] Source:Brain;140(6):1633-1642, 2017 Jun 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:See Moskowitz (doi:10.1093/brain/awx099) for a scientific commentary on this article.The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache. We used the sensitive and validated technique of dynamic contrast-enhanced high-field magnetic resonance imaging to simultaneously investigate blood-brain barrier permeability and tissue perfusion in the brainstem (at the level of the lower pons), visual cortex, and brain areas of the anterior, middle and posterior circulation during spontaneous attacks of migraine with aura. Patients reported to our institution to undergo magnetic resonance imaging during the headache phase after presenting with typical visual aura. Nineteen patients were scanned during attacks and on an attack-free day. The mean time from attack onset to scanning was 7.6 h. We found increased brainstem perfusion bilaterally during migraine with aura attacks. Perfusion also increased in the visual cortex and posterior white matter following migraine aura. We found no increase in blood-brain barrier permeability in any of the investigated regions. There was no correlation between blood-brain barrier permeability, brain perfusion, and time from symptom onset to examination or pain intensity. Our findings demonstrate hyperperfusion in brainstem during the headache phase of migraine with aura, while the blood-brain barrier remains intact during attacks of migraine with aura. These data thus contradict the preclinical hypothesis of cortical spreading depression-induced blood-brain barrier disruption as a possible mechanism linking aura and headache.awx089media15422686892001.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/diagnóstico por imagem
Tronco Encefálico/diagnóstico por imagem
Imagem por Ressonância Magnética/métodos
Enxaqueca com Aura/diagnóstico por imagem
Córtex Visual/diagnóstico por imagem
Substância Branca/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Tronco Encefálico/irrigação sanguínea
Feminino
Seres Humanos
Masculino
Meia-Idade
Enxaqueca com Aura/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx089


  10 / 1616 MEDLINE  
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[PMID]:28356463
[Au] Autor:DaSilva AF; Nascimento TD; Jassar H; Heffernan J; Toback RL; Lucas S; DosSantos MF; Bellile EL; Boonstra PS; Taylor JMG; Casey KL; Koeppe RA; Smith YR; Zubieta JK
[Ad] Endereço:From the Headache & Orofacial Pain Effort (H.O.P.E.), Biologic & Materials Sciences Department, School of Dentistry (A.F.D., T.D.N., H.J., R.L.T., S.L., M.F.D.), Translational Neuroimaging Laboratory, Molecular & Behavioral Neuroscience Institute (A.F.D., J.H.. J.-K.Z.), Department of Bi
[Ti] Título:Dopamine D2/D3 imbalance during migraine attack and allodynia in vivo.
[So] Source:Neurology;88(17):1634-1641, 2017 Apr 25.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate in vivo the dynamics of endogenous dopamine (DA) neurotransmission during migraine ictus with allodynia. METHODS: We examined 8 episodic migraineurs and 8 healthy controls (HC) using PET with [ C]raclopride. The uptake measure of [ C]raclopride, nondisplaceable binding potential (BP ), would increase when there was a reduction in endogenous DA release. The opposite is true for a decrease in [ C]raclopride BP . Patients were scanned twice: one PET session was during a spontaneous migraine ictus at rest, followed by a sustained thermal pain threshold (STPT) challenge on the trigeminal region, eliciting an allodynia experience; another was during interictal phase. RESULTS: Striatal BP of [ C]raclopride in migraineurs did not differ from HC. We found a significant increase in [ C]raclopride BP in the striatum region of migraineurs during both headache attack and allodynia relative to interictal phase. However, when compared to the migraine attack at rest, migraineurs during the STPT challenge had a significant sudden reduction in [ C]raclopride BP in the insula. Such directional change was also observed in the caudate of HC relative to the interictal phase during challenge. Furthermore, ictal changes in [ C]raclopride BP in migraineurs at rest were positively correlated with the chronicity of migraine attacks, and negatively correlated with the frequency during challenge. CONCLUSIONS: Our findings demonstrate that there is an imbalanced uptake of [ C]raclopride during the headache attack and ictal allodynia, which indicates reduction and fluctuation in ictal endogenous DA release in migraineurs. Moreover, the longer the history and recurrence of migraine attacks, the lower the ictal endogenous DA release.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Hiperalgesia/metabolismo
Enxaqueca com Aura/metabolismo
Enxaqueca sem Aura/metabolismo
Receptores de Dopamina D2/metabolismo
Receptores de Dopamina D3/metabolismo
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico
Dopamina/metabolismo
Feminino
Temperatura Alta
Seres Humanos
Hiperalgesia/diagnóstico por imagem
Masculino
Enxaqueca com Aura/diagnóstico por imagem
Enxaqueca sem Aura/diagnóstico por imagem
Estimulação Física
Tomografia por Emissão de Pósitrons
Racloprida
Compostos Radiofarmacêuticos
Descanso
Transmissão Sináptica/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DRD2 protein, human); 0 (DRD3 protein, human); 0 (Radiopharmaceuticals); 0 (Receptors, Dopamine D2); 0 (Receptors, Dopamine D3); 430K3SOZ7G (Raclopride); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000003861



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