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| [PMID]: | 29262276 |
| [Au] Autor: | Kulkarni AV; Schiff SJ; Mbabazi-Kabachelor E; Mugamba J; Ssenyonga P; Donnelly R; Levenbach J; Monga V; Peterson M; MacDonald M; Cherukuri V; Warf BC |
| [Ad] Endereço: | From the University of Toronto (A.V.K.) and the Hospital for Sick Children (A.V.K., R.D., J.L.), Toronto; Pennsylvania State University, University Park (S.J.S., V.M., M.P., M.M., V.C.); CURE Children's Hospital of Uganda, Mbale (E.M.-K., J.M., P.S., B.C.W.); and Harvard Medical School and Boston Ch |
| [Ti] Título: | Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda. |
| [So] Source: | N Engl J Med;377(25):2456-2464, 2017 12 21. | | [Is] ISSN: | 1533-4406 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | BACKGROUND: Postinfectious hydrocephalus in infants is a major health problem in sub-Saharan Africa. The conventional treatment is ventriculoperitoneal shunting, but surgeons are usually not immediately available to revise shunts when they fail. Endoscopic third ventriculostomy with choroid plexus cauterization (ETV-CPC) is an alternative treatment that is less subject to late failure but is also less likely than shunting to result in a reduction in ventricular size that might facilitate better brain growth and cognitive outcomes. METHODS: We conducted a randomized trial to evaluate cognitive outcomes after ETV-CPC versus ventriculoperitoneal shunting in Ugandan infants with postinfectious hydrocephalus. The primary outcome was the Bayley Scales of Infant Development, Third Edition (BSID-3), cognitive scaled score 12 months after surgery (scores range from 1 to 19, with higher scores indicating better performance). The secondary outcomes were BSID-3 motor and language scores, treatment failure (defined as treatment-related death or the need for repeat surgery), and brain volume measured on computed tomography. RESULTS: A total of 100 infants were enrolled; 51 were randomly assigned to undergo ETV-CPC, and 49 were assigned to undergo ventriculoperitoneal shunting. The median BSID-3 cognitive scores at 12 months did not differ significantly between the treatment groups (a score of 4 for ETV-CPC and 2 for ventriculoperitoneal shunting; Hodges-Lehmann estimated difference, 0; 95% confidence interval [CI], -2 to 0; P=0.35). There was no significant difference between the ETV-CPC group and the ventriculoperitoneal-shunt group in BSID-3 motor or language scores, rates of treatment failure (35% and 24%, respectively; hazard ratio, 0.7; 95% CI, 0.3 to 1.5; P=0.24), or brain volume (z score, -2.4 and -2.1, respectively; estimated difference, 0.3; 95% CI, -0.3 to 1.0; P=0.12). CONCLUSIONS: This single-center study involving Ugandan infants with postinfectious hydrocephalus showed no significant difference between endoscopic ETV-CPC and ventriculoperitoneal shunting with regard to cognitive outcomes at 12 months. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01936272 .). |
| [Mh] Termos MeSH primário: |
Cauterização
Desenvolvimento Infantil
Plexo Corióideo/cirurgia
Hidrocefalia/cirurgia
Derivação Ventriculoperitoneal
Ventriculostomia
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| [Mh] Termos MeSH secundário: |
Linguagem Infantil
Cognição
Feminino
Seres Humanos
Lactente
Masculino
Destreza Motora
Testes Neuropsicológicos
Uganda
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| [Pt] Tipo de publicação: | COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL |
| [Em] Mês de entrada: | 1801 |
| [Cu] Atualização por classe: | 180207 |
[Lr] Data última revisão:
| 180207 |
| [Sb] Subgrupo de revista: | AIM; IM |
| [Da] Data de entrada para processamento: | 171221 |
| [Cl] Clinical Trial: | ClinicalTrial
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| [St] Status: | MEDLINE |
| [do] DOI: | 10.1056/NEJMoa1707568 |
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