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[PMID]:28453783
[Au] Autor:Ferré Á; Poca MA; de la Calzada MD; Moncho D; Romero O; Sampol G; Sahuquillo J
[Ad] Endereço:Clinical Neurophysiology Department, Barcelona, Spain.
[Ti] Título:Sleep-Related Breathing Disorders in Chiari Malformation Type 1: A Prospective Study of 90 Patients.
[So] Source:Sleep;40(6), 2017 Jun 01.
[Is] ISSN:1550-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Study objective: The aim of the present study is to describe the prevalence of sleep disorders in a large group of patients with Chiari malformation type 1 (CM-1) and determine the presence of risk factors associated with these abnormalities. Methods: Prospective study with consecutive patient selection. We included 90 adult patients with CM-1, defined by the presence of a cerebellar tonsillar descent (TD) ≥3 mm. Clinical, neuroradiological studies, and nocturnal polysomnography (PSG) was carried out. In addition, patients were also subclassified into 2 CM subtypes: CM-1, with the obex above the foramen magnum (FM) and CM-1.5, in which along with a TD ≥3 mm, the obex was located below the FM. Results: We observed a high prevalence (50%) of sleep-related breathing disorders (SRBDs) with predominant hypopnea. Only six patients showed a central apnea index of ≥5. Hypoventilation was observed in only three patients. SRBD severity was associated with male sex, older age, excess weight, and the presence of hydrocephalus. No differences in clinical or PSG parameters were found when comparing CM subtypes (CM-1 and CM-1.5). Sleep architecture study showed decreased sleep efficiency with an increase in arousal and waking after sleep onset. The presence of SRBDs was found to be associated with poorer sleep architecture parameters. Conclusions: This study confirms a high prevalence of SRBDs in patients with CM-1 and CM-1.5, with a predominant obstructive component. Nocturnal PSG recordings should be systematically conducted in these patients, especially those who are male, older, or overweight or those who present hydrocephalus.
[Mh] Termos MeSH primário: Malformação de Arnold-Chiari/epidemiologia
Dissonias/epidemiologia
Dissonias/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Distribuição por Idade
Malformação de Arnold-Chiari/classificação
Nível de Alerta
Feminino
Seres Humanos
Hidrocefalia/epidemiologia
Hipoventilação/epidemiologia
Masculino
Sobrepeso/epidemiologia
Polissonografia
Prevalência
Estudos Prospectivos
Fatores de Risco
Caracteres Sexuais
Síndromes da Apneia do Sono/epidemiologia
Síndromes da Apneia do Sono/fisiopatologia
Vigília
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/sleep/zsx069


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[PMID]:28460636
[Au] Autor:Saugier-Veber P; Marguet F; Lecoquierre F; Adle-Biassette H; Guimiot F; Cipriani S; Patrier S; Brasseur-Daudruy M; Goldenberg A; Layet V; Capri Y; Gérard M; Frébourg T; Laquerrière A
[Ad] Endereço:Department of Genetics, Normandie Univ, UNIROUEN, INSERM U1245, Normandy Centre for Genomic and Personalized Medicine, Rouen University Hospital, F76000, Rouen, France.
[Ti] Título:Hydrocephalus due to multiple ependymal malformations is caused by mutations in the MPDZ gene.
[So] Source:Acta Neuropathol Commun;5(1):36, 2017 05 01.
[Is] ISSN:2051-5960
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Congenital hydrocephalus is considered as either acquired due to haemorrhage, infection or neoplasia or as of developmental nature and is divided into two subgroups, communicating and obstructive. Congenital hydrocephalus is either syndromic or non-syndromic, and in the latter no cause is found in more than half of the patients. In patients with isolated hydrocephalus, L1CAM mutations represent the most common aetiology. More recently, a founder mutation has also been reported in the MPDZ gene in foetuses presenting massive hydrocephalus, but the neuropathology remains unknown. We describe here three novel homozygous null mutations in the MPDZ gene in foetuses whose post-mortem examination has revealed a homogeneous phenotype characterized by multiple ependymal malformations along the aqueduct of Sylvius, the third and fourth ventricles as well as the central canal of the medulla, consisting in multifocal rosettes with immature cell accumulation in the vicinity of ependymal lining early detached from the ventricular zone. MPDZ also named MUPP1 is an essential component of tight junctions which are expressed from early brain development in the choroid plexuses and ependyma. Alterations in the formation of tight junctions within the ependyma very likely account for the lesions observed and highlight for the first time that primary multifocal ependymal malformations of the ventricular system is genetically determined in humans. Therefore, MPDZ sequencing should be performed when neuropathological examination reveals multifocal ependymal rosette formation within the aqueduct of Sylvius, of the third and fourth ventricles and of the central canal of the medulla.
[Mh] Termos MeSH primário: Proteínas de Transporte/genética
Epêndima/anormalidades
Doenças Fetais/genética
Hidrocefalia/genética
Mutação com Perda de Função
[Mh] Termos MeSH secundário: Adulto
Epêndima/diagnóstico por imagem
Família
Feminino
Doenças Fetais/diagnóstico por imagem
Doenças Fetais/etiologia
Doenças Fetais/patologia
Homozigoto
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Hidrocefalia/etiologia
Hidrocefalia/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (MPDZ protein, human)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s40478-017-0438-4


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[PMID]:29223275
[Au] Autor:Correa V; Vintch J; Lanks C
[Ad] Endereço:Division of Pulmonary and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance, CA.
[Ti] Título:A 26-Year-Old Man From Mexico With Headaches, Dysuria, and a Right Scrotal Mass.
[So] Source:Chest;152(6):e147-e150, 2017 12.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE PRESENTATION: A 26-year-old man with no medical history was admitted to the hospital for evaluation of his change in mental status. He was noted to be agitated at work and had difficulty walking for 2 days before being brought in to the ED by his family. According to his uncle, the patient had been complaining of a headache and pain with urination for approximately 1 week. He was born in Guerrero, Mexico (a small farm town), and moved to Los Angeles, California, in 2008.
[Mh] Termos MeSH primário: Disuria/etiologia
Cefaleia/etiologia
Hidrocefalia/complicações
Mycobacterium bovis/isolamento & purificação
Escroto/diagnóstico por imagem
Tuberculose dos Genitais Masculinos/diagnóstico
[Mh] Termos MeSH secundário: Adulto
DNA Bacteriano/análise
Diagnóstico Diferencial
Disuria/diagnóstico
Cefaleia/diagnóstico
Seres Humanos
Hidrocefalia/diagnóstico
Imagem por Ressonância Magnética
Masculino
Mycobacterium bovis/genética
Escroto/microbiologia
Tuberculose dos Genitais Masculinos/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


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[PMID]:29390310
[Au] Autor:Jang SH; Chang CH; Jung YJ; Lee HD
[Ad] Endereço:Department of Physical Medicine and Rehabilitation.
[Ti] Título:Recovery of akinetic mutism and injured prefronto-caudate tract following shunt operation for hydrocephalus and rehabilitation: A case report.
[So] Source:Medicine (Baltimore);96(50):e9117, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A 76-year-old female patient was diagnosed with an aneurysmal subarachnoid hemorrhage following rupture of a right posterior communicating artery aneurysm. PATIENT CONCERNS: She was treated surgically with clipping of the aneurysmal neck. Six months after onset, when starting rehabilitation at our hospital, she showed no spontaneous movement or speech. DIAGNOSES:: aneurysmal subarachnoid hemorrhage following rupture of a right posterior communicating artery aneurysm. INTERVENTIONS: During 2 months' rehabilitation, her AM did not improve significantly. As there was no apparent change, she underwent a ventriculo-peritoneal shunt operation for hydrocephalus 8 months after her stroke. After the surgery, she remained in the AM state, but participated in a comprehensive rehabilitative management program similar to that before shunt operation. During 1 month's intensive rehabilitation, her AM gradually improved. At 9 months after onset, she became able to perform some daily activities by herself including eating, washing, and dressing. In addition, she could speak with some fluency. OUTCOMES: On 6-month DTT, the neural connectivity of the caudate nucleus (CN) to the medial prefrontal cortex (PFC, Broadmann area [BA]: 10 and 12) and orbito-frontal cortex (BA 11 and 13) was low in both hemispheres. However, the neural connectivity of the CN to the medial PFC increased on both sides on 9-month DTT. The integrity of the arcuate fasciculus (AF) was preserved in both hemispheres on both 6- and 9-month DTTs. LESSONS: Recovery of AM and injured PCTs was observed in a stroke patient.
[Mh] Termos MeSH primário: Afasia Acinética/etiologia
Afasia Acinética/reabilitação
Núcleo Caudado/lesões
Hidrocefalia/etiologia
Hidrocefalia/cirurgia
Córtex Pré-Frontal/lesões
Hemorragia Subaracnóidea/complicações
Hemorragia Subaracnóidea/cirurgia
Derivação Ventriculoperitoneal
[Mh] Termos MeSH secundário: Atividades Cotidianas
Idoso
Feminino
Seres Humanos
Recuperação de Função Fisiológica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009117


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[PMID]:29384951
[Au] Autor:Ouyang L; Yang F
[Ad] Endereço:Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Cole-Carpenter syndrome-1 with a de novo heterozygous deletion in the P4HB gene in a Chinese girl: A case report.
[So] Source:Medicine (Baltimore);96(52):e9504, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cole-Carpenter syndrome-1 (CLCRP1) is an independent osteogenesis imperfect (OI)-like disorder that manifests as bone fragility, craniosynostosis, ocular proptosis, hydrocephalus, and distinctive facial features. Only 2 types of mutation sites in the P4HB and CRTAP genes have been reported. PATIENT CONCERNS: A 14-month-old Chinese girl presented with prominent ocular proptosis, frontal bossing, craniosynostosis, plump anterior fontanel, growth retardation, osteopenia, and distinctive facial features that were strikingly similar to those in the original 2 cases. DIAGNOSES: Whole-exome sequencing revealed a novel deletion variation in exons 5 to 8 of the P4HB gene, which was found to be heterozygous using fluorogenic quantitative-polymerase chain reaction. LESSONS: This de novo deletion mutation in exons 5 to 8 of the P4HB gene advances our understanding of CLCRP1, expands the mutation spectrum of P4HB, and diversifies the cases reported for this condition.
[Mh] Termos MeSH primário: Craniossinostoses/genética
Anormalidades do Olho/genética
Hidrocefalia/genética
Osteogênese Imperfeita/genética
Pró-Colágeno-Prolina Dioxigenase/genética
Isomerases de Dissulfetos de Proteínas/genética
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Asiático
China
Craniossinostoses/patologia
Anormalidades do Olho/patologia
Feminino
Seres Humanos
Hidrocefalia/patologia
Lactente
Osteogênese Imperfeita/patologia
Deleção de Sequência
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.11.2 (Procollagen-Proline Dioxygenase); EC 5.3.4.1 (P4HB protein, human); EC 5.3.4.1 (Protein Disulfide-Isomerases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009504


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[PMID]:29339864
[Au] Autor:Norkett W; McLone DG; Bowman R
[Ad] Endereço:Ann and Robert H. Lurie Children's Hospital of Chicago.
[Ti] Título:Current Management Strategies of Hydrocephalus in the Child With Open Spina Bifida.
[So] Source:Top Spinal Cord Inj Rehabil;22(4):241-246, 2016.
[Is] ISSN:1945-5763
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Symptomatic hydrocephalus is a common condition associated with myelomeningocele (open spina bifida). Traditionally, hydrocephalus was treated with insertion of a ventriculo-peritoneal (VP) shunt. This has been the standard of treatment since the introduction of the Holter shunt valve for the VP shunt in the late 1950s. Now there are other treatments that offer alternatives to VP shunt diversion for hydrocephalus. This article is a review of hydrocephalus associated with myelomeningocele and its treatment options. Treatment in the form of a VP shunt, endoscopic third ventriculostomy (ETV), and conservative management are discussed.
[Mh] Termos MeSH primário: Hidrocefalia/terapia
Espinha Bífida Cística/terapia
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Terceiro Ventrículo
Resultado do Tratamento
Ventriculostomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1310/sci2204-241


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[PMID]:29369173
[Au] Autor:Jang SH; Chang CH; Jung YJ; Seo YS
[Ad] Endereço:Department of Physical Medicine and Rehabilitation.
[Ti] Título:Restoration of the corticoreticular pathway following shunt operation for hydrocephalus in a stroke patient.
[So] Source:Medicine (Baltimore);97(4):e9512, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a stroke patient who showed restoration of discontinued corticoreticular pathways (CRPs) on serial diffusion tensor tractography (DTT) concurrent with recovery of gait disturbance following shunt operation for hydrocephalus. PATIENT CONCERNS: A 67-year-old female patient underwent stereotactic drainage for management of intraventricular hemorrhage due to a rupture of the left posterior communicating artery. DIAGNOSES: After 4 weeks from onset, the patient exhibited quadriparesis with more severe weakness in the proximal muscles and could not even stand or walk. She underwent comprehensive rehabilitation for 3 weeks. Her quadriparesis, as a result of hydrocephalus, did not improve significantly. INTERVENTIONS: On the pre-op DTT, discontinuations (the right CRP: at subcortical white matter level, and the left CRP: at the midbrain level) of the CRP fibers from the premotor cortex were observed in both hemispheres. OUTCOMES: She underwent a ventriculo-peritoneal shunt operation and her quadriparesis improved, especially the proximal muscles. Consequently, she could walk with mild assistance on an even floor at 5 days and walk on stairs at 4 weeks after the shunt operation. On the post-op DTT, the discontinued CRP fibers were elongated to the premotor cortex in both hemispheres. LESSONS: Restoration of discontinued CRPs concurrent with recovery of gait disturbance following shunt operation for hydrocephalus was demonstrated in a stroke patient.
[Mh] Termos MeSH primário: Hidrocefalia/cirurgia
Quadriplegia/cirurgia
Formação Reticular/cirurgia
Acidente Vascular Cerebral/complicações
Derivação Ventriculoperitoneal/métodos
[Mh] Termos MeSH secundário: Idoso
Hemorragia Cerebral/etiologia
Hemorragia Cerebral/cirurgia
Drenagem/métodos
Feminino
Seres Humanos
Hidrocefalia/etiologia
Quadriplegia/etiologia
Recuperação de Função Fisiológica
Formação Reticular/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009512


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Registro de Ensaios Clínicos
Registro de Ensaios Clínicos
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[PMID]:29262276
[Au] Autor:Kulkarni AV; Schiff SJ; Mbabazi-Kabachelor E; Mugamba J; Ssenyonga P; Donnelly R; Levenbach J; Monga V; Peterson M; MacDonald M; Cherukuri V; Warf BC
[Ad] Endereço:From the University of Toronto (A.V.K.) and the Hospital for Sick Children (A.V.K., R.D., J.L.), Toronto; Pennsylvania State University, University Park (S.J.S., V.M., M.P., M.M., V.C.); CURE Children's Hospital of Uganda, Mbale (E.M.-K., J.M., P.S., B.C.W.); and Harvard Medical School and Boston Ch
[Ti] Título:Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda.
[So] Source:N Engl J Med;377(25):2456-2464, 2017 12 21.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postinfectious hydrocephalus in infants is a major health problem in sub-Saharan Africa. The conventional treatment is ventriculoperitoneal shunting, but surgeons are usually not immediately available to revise shunts when they fail. Endoscopic third ventriculostomy with choroid plexus cauterization (ETV-CPC) is an alternative treatment that is less subject to late failure but is also less likely than shunting to result in a reduction in ventricular size that might facilitate better brain growth and cognitive outcomes. METHODS: We conducted a randomized trial to evaluate cognitive outcomes after ETV-CPC versus ventriculoperitoneal shunting in Ugandan infants with postinfectious hydrocephalus. The primary outcome was the Bayley Scales of Infant Development, Third Edition (BSID-3), cognitive scaled score 12 months after surgery (scores range from 1 to 19, with higher scores indicating better performance). The secondary outcomes were BSID-3 motor and language scores, treatment failure (defined as treatment-related death or the need for repeat surgery), and brain volume measured on computed tomography. RESULTS: A total of 100 infants were enrolled; 51 were randomly assigned to undergo ETV-CPC, and 49 were assigned to undergo ventriculoperitoneal shunting. The median BSID-3 cognitive scores at 12 months did not differ significantly between the treatment groups (a score of 4 for ETV-CPC and 2 for ventriculoperitoneal shunting; Hodges-Lehmann estimated difference, 0; 95% confidence interval [CI], -2 to 0; P=0.35). There was no significant difference between the ETV-CPC group and the ventriculoperitoneal-shunt group in BSID-3 motor or language scores, rates of treatment failure (35% and 24%, respectively; hazard ratio, 0.7; 95% CI, 0.3 to 1.5; P=0.24), or brain volume (z score, -2.4 and -2.1, respectively; estimated difference, 0.3; 95% CI, -0.3 to 1.0; P=0.12). CONCLUSIONS: This single-center study involving Ugandan infants with postinfectious hydrocephalus showed no significant difference between endoscopic ETV-CPC and ventriculoperitoneal shunting with regard to cognitive outcomes at 12 months. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01936272 .).
[Mh] Termos MeSH primário: Cauterização
Desenvolvimento Infantil
Plexo Corióideo/cirurgia
Hidrocefalia/cirurgia
Derivação Ventriculoperitoneal
Ventriculostomia
[Mh] Termos MeSH secundário: Linguagem Infantil
Cognição
Feminino
Seres Humanos
Lactente
Masculino
Destreza Motora
Testes Neuropsicológicos
Uganda
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1707568


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[PMID]:28744710
[Au] Autor:Vishnu Bhat B; Mondal N
[Ad] Endereço:Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India. drvishnubhat@yahoo.com.
[Ti] Título:Outcome of Extreme Preterm Babies Treated with Ventriculo-Peritoneal Shunt for Post Hemorrhagic Hydrocephalus.
[So] Source:Indian J Pediatr;84(9):653-654, 2017 09.
[Is] ISSN:0973-7693
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Hidrocefalia/cirurgia
Derivação Ventriculoperitoneal
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
Recém-Nascido
Doenças do Recém-Nascido
Doenças do Prematuro
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s12098-017-2427-9


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[PMID]:29232410
[Au] Autor:Na MK; Won YD; Kim CH; Kim JM; Cheong JH; Ryu JI; Han MH
[Ad] Endereço:Department of Neurosurgery, Hanyang University Guri Hospital, Gyeongchun-ro, Guri, Gyonggi-do, Korea.
[Ti] Título:Early variations of laboratory parameters predicting shunt-dependent hydrocephalus after subarachnoid hemorrhage.
[So] Source:PLoS One;12(12):e0189499, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Hydrocephalus is a frequent complication following subarachnoid hemorrhage. Few studies investigated the association between laboratory parameters and shunt-dependent hydrocephalus. This study aimed to investigate the variations of laboratory parameters after subarachnoid hemorrhage. We also attempted to identify predictive laboratory parameters for shunt-dependent hydrocephalus. METHODS: Multiple imputation was performed to fill the missing laboratory data using Bayesian methods in SPSS. We used univariate and multivariate Cox regression analyses to calculate hazard ratios for shunt-dependent hydrocephalus based on clinical and laboratory factors. The area under the receiver operating characteristic curve was used to determine the laboratory risk values predicting shunt-dependent hydrocephalus. RESULTS: We included 181 participants with a mean age of 54.4 years. Higher sodium (hazard ratio, 1.53; 95% confidence interval, 1.13-2.07; p = 0.005), lower potassium, and higher glucose levels were associated with higher shunt-dependent hydrocephalus. The receiver operating characteristic curve analysis showed that the areas under the curve of sodium, potassium, and glucose were 0.649 (cutoff value, 142.75 mEq/L), 0.609 (cutoff value, 3.04 mmol/L), and 0.664 (cutoff value, 140.51 mg/dL), respectively. CONCLUSIONS: Despite the exploratory nature of this study, we found that higher sodium, lower potassium, and higher glucose levels were predictive values for shunt-dependent hydrocephalus from postoperative day (POD) 1 to POD 12-16 after subarachnoid hemorrhage. Strict correction of electrolyte imbalance seems necessary to reduce shunt-dependent hydrocephalus. Further large studies are warranted to confirm our findings.
[Mh] Termos MeSH primário: Derivações do Líquido Cefalorraquidiano
Hidrocefalia/etiologia
Hemorragia Subaracnóidea/complicações
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hidrocefalia/patologia
Hidrocefalia/cirurgia
Masculino
Meia-Idade
Curva ROC
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189499



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