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[PMID]:28453858
[Au] Autor:McCormack SE; Li D; Kim YJ; Lee JY; Kim SH; Rapaport R; Levine MA
[Ad] Endereço:Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
[Ti] Título:Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome.
[So] Source:J Clin Endocrinol Metab;102(7):2501-2507, 2017 Jul 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Pituitary stalk interruption syndrome (PSIS, ORPHA95496) is a congenital defect of the pituitary gland characterized by the triad of a very thin/interrupted pituitary stalk, an ectopic (or absent) posterior pituitary gland, and hypoplasia or aplasia of the anterior pituitary gland. Complex genetic patterns of inheritance of this disorder are increasingly recognized. Objective: The objective of this study was to identify a genetic cause of PSIS in an affected child. Methods: Whole exome sequencing (WES) was performed by using standard techniques, with prioritized genetic variants confirmed via Sanger sequencing. To investigate the effects of one candidate variant on mutant WDR11 function, Western blotting and coimmunofluorescence were used to assess binding capacity, and leptomycin B exposure along with immunofluorescence was used to assess nuclear localization. Results: We describe a child who presented in infancy with combined pituitary hormone deficiencies and whose brain imaging demonstrated a small anterior pituitary, ectopic posterior pituitary, and a thin, interrupted stalk. WES demonstrated heterozygous missense mutations in two genes required for pituitary development, a known loss-of-function mutation in PROKR2 (c.253C>T;p.R85C) inherited from an unaffected mother, and a WDR11 (c.1306A>G;p.I436V) mutation inherited from an unaffected father. Mutant WDR11 loses its capacity to bind to its functional partner, EMX1, and to localize to the nucleus. Conclusions: WES in a child with PSIS and his unaffected family implicates a digenic mechanism of inheritance. In cases of hypopituitarism in which there is incomplete segregation of a monogenic genotype with the phenotype, the possibility that a second genetic locus is involved should be considered.
[Mh] Termos MeSH primário: Predisposição Genética para Doença
Hipopituitarismo/genética
Proteínas de Membrana/genética
Mutação
Hipófise/anormalidades
Proteínas Proto-Oncogênicas/genética
Receptores Acoplados a Proteínas-G/genética
Receptores de Peptídeos/genética
[Mh] Termos MeSH secundário: Exoma/genética
Genótipo
Heterozigoto
Seres Humanos
Hipopituitarismo/congênito
Hipopituitarismo/patologia
Recém-Nascido
Masculino
Linhagem
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (PROKR2 protein, human); 0 (Proto-Oncogene Proteins); 0 (Receptors, G-Protein-Coupled); 0 (Receptors, Peptide); 0 (WDR11 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2017-00332


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[PMID]:29217803
[Au] Autor:Vyas V; Kumar A; Jain V
[Ad] Endereço:Department of Pediatrics,AIIMS, Jodhpur; and #Division of Pediatric Endocrinology, Department of Pediatrics, AIIMS, New Delhi; India. Correspondence to: Dr Vandana Jain, Professor, Division of Pediatric Endocrinology, Department of Pediatrics, All India Institute of Medical Sciences, NewDelhi 110029. drvandanajain@gmail.com.
[Ti] Título:Growth Hormone Deficiency in Children: From Suspecting to Diagnosing.
[So] Source:Indian Pediatr;54(11):955-960, 2017 Nov 15.
[Is] ISSN:0974-7559
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Isolated Growth hormone deficiency is an important and treatable cause of short stature. However, it is often difficult to diagnose the condition with certainty due to the lack of a single robust diagnostic test. Short children, other than those with the classical phenotype of immature chubby facies, truncal obesity and micropenis in boys, or those with history of cranial lesions with known association with hypopituitarism, should be evaluated for growth hormone deficiency only after excluding the other more common conditions. These children typically have height markedly below that expected for their midparental height with low height velocity and delayed bone age. Growth hormone levels should be checked by provocative testing, after ensuring that the child is euthyroid, and after priming with sex steroids if indicated. Low levels of Insulin-like growth factor 1 and Insulin-like growth factor binding protein 3 and pituitary abnormalities on neuroimaging provide important corroborative evidence to the diagnosis.
[Mh] Termos MeSH primário: Transtornos do Crescimento
Hormônio do Crescimento Humano/deficiência
Hipopituitarismo
[Mh] Termos MeSH secundário: Estatura/fisiologia
Criança
Feminino
Transtornos do Crescimento/diagnóstico
Transtornos do Crescimento/etiologia
Transtornos do Crescimento/fisiopatologia
Seres Humanos
Hipopituitarismo/diagnóstico
Hipopituitarismo/etiologia
Hipopituitarismo/fisiopatologia
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12629-01-5 (Human Growth Hormone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29182204
[Au] Autor:García-Castro JM; García-Martín A; Guirao-Arrabal E; Carrillo-Alascio PL
[Ad] Endereço:Unidad de Medicina Interna, Hospital La Inmaculada, Almería, España.
[Ti] Título:[Long QT syndrome and polymorphic ventricular tachycardia due to hypopituitarism. Report of one case].
[Ti] Título:Síndrome de QT largo y taquicardia ventricular en torsade de pointes secundarios a hipopituitarismo: una asociación a tener en cuenta. Caso clínico..
[So] Source:Rev Med Chil;145(7):941-944, 2017 Jul.
[Is] ISSN:0717-6163
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:Symptoms of hypopituitarism are usually chronic and nonspecific, but rarely the disease can have acute and life threatening manifestations. We report a 53 years old female with a pituitary adenoma that was admitted to our hospital because of syncope. The electrocardiogram showed sinus bradycardia with a prolonged QT interval. Frequent runs of non-sustained polymorphic ventricular tachycardia were noted on telemetry. The patient had a history of severe acute headaches in the previous days and laboratory tests revealed severe secondary hypothyroidism, adrenal insufficiency and a decrease in pituitary hormones. A magnetic resonance imaging of the head showed changes in the size and contrast enhancement of the adenoma. A diagnosis of hypopituitarism secondary to pituitary apoplexy was made and treatment with hydrocortisone and, subsequently, levothyroxine was started. Hormonal disorders such as hypothyroidism, adrenal insufficiency or hypopituitarism should be considered as unusual causes for reversible cardiomyopathy, long QT syndrome and ventricular arrhythmias.
[Mh] Termos MeSH primário: Adenoma/complicações
Hipopituitarismo/complicações
Síndrome do QT Longo/etiologia
Neoplasias Hipofisárias/complicações
Taquicardia Ventricular/etiologia
[Mh] Termos MeSH secundário: Eletrocardiografia
Feminino
Seres Humanos
Síndrome do QT Longo/diagnóstico
Imagem por Ressonância Magnética
Meia-Idade
Taquicardia Ventricular/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29095270
[Au] Autor:Gilis-Januszewska A; Kluczynski L; Wilusz M; Pantoflinski J; Turek-Jabrocka R; Pach D; Hubalewska-Dydejczyk A
[Ad] Endereço:aDepartment of Endocrinology, Jagiellonian University Medical College bDepartment of Endocrinology, University Hospital, Kraków, Poland.
[Ti] Título:Pituitary insufficiency following traumatic thoracic injury in an adolescent male patient: A case report and literature review.
[So] Source:Medicine (Baltimore);96(44):e8406, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence. We also review the literature of similar cases. PATIENT CONCERNS: We present a case of a 24-years-old male. In 2007, at the age of 15 he underwent a severe traffic accident followed by thoracic injury with concussion, hemothorax and dissection of the aorta requiring aortic stent-graft implantation. DIAGNOSES: During the post-traumatic period, transient polydipsia and polyuria symptoms were observed. The patient had no medical history of any serious disease before the accident, his growth and pubertal development was normal. After the accident the patient did not undergo any routine medical check-ups. In 2013 gonadal axis deficiency was diagnosed during investigation of libido problems. Following the diagnosis testosterone replacement therapy was initiated. INTERVENTIONS: Further endocrinological investigation was carried out in 2016. The patient's main complaints were decreased mood and poor physical fitness. BMI was 27.34 kg/m, with a tendency to abdominal fat distribution. The patient's height is 160 cm, while Mid Parental Height (MPH) is 173.5 cm. Decreased bone density was found in DEXA examination. Serum growth hormone level (GH) was normal while insulin-like growth factor-1 (IGF-1) level was below normal. Insulin tolerance test (ITT) and low levels of IGF-1 confirmed somatotropic axis deficiency. Nuclear magnetic resonance (NMR) of the hypothalamo-pituitary region showed no abnormalities. PROP 1 and other common genetic mutations associated with GH deficits were excluded. Testosterone treatment was continued. The patient increased physical activity and implemented diet. OUTCOMES: The patient has lost weight, improved physical activity performance and is feeling better. The procedure to start GH supplementation is now in process. LESSONS: Based on our case and available literature we suggest that adolescent patients after traumatic brain injuries may require precise investigation and strict monitoring due to the possibility of unrecognized hypopituitarism.
[Mh] Termos MeSH primário: Acidentes de Trânsito
Androgênios/uso terapêutico
Terapia de Reposição Hormonal/métodos
Hipopituitarismo/etiologia
Testosterona/uso terapêutico
Traumatismos Torácicos/complicações
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Hipopituitarismo/tratamento farmacológico
Masculino
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androgens); 3XMK78S47O (Testosterone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008406


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[PMID]:28860331
[Au] Autor:Tan CL; Alavi SA; Baldeweg SE; Belli A; Carson A; Feeney C; Goldstone AP; Greenwood R; Menon DK; Simpson HL; Toogood AA; Gurnell M; Hutchinson PJ
[Ad] Endereço:Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB20QQ, UK.
[Ti] Título:The screening and management of pituitary dysfunction following traumatic brain injury in adults: British Neurotrauma Group guidance.
[So] Source:J Neurol Neurosurg Psychiatry;88(11):971-981, 2017 Nov.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pituitary dysfunction is a recognised, but potentially underdiagnosed complication of traumatic brain injury (TBI). Post-traumatic hypopituitarism (PTHP) can have major consequences for patients physically, psychologically, emotionally and socially, leading to reduced quality of life, depression and poor rehabilitation outcome. However, studies on the incidence of PTHP have yielded highly variable findings. The risk factors and pathophysiology of this condition are also not yet fully understood. There is currently no national consensus for the screening and detection of PTHP in patients with TBI, with practice likely varying significantly between centres. In view of this, a guidance development group consisting of expert clinicians involved in the care of patients with TBI, including neurosurgeons, neurologists, neurointensivists and endocrinologists, was convened to formulate national guidance with the aim of facilitating consistency and uniformity in the care of patients with TBI, and ensuring timely detection or exclusion of PTHP where appropriate. This article summarises the current literature on PTHP, and sets out guidance for the screening and management of pituitary dysfunction in adult patients with TBI. It is hoped that future research will lead to more definitive recommendations in the form of guidelines.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/diagnóstico
Lesões Encefálicas Traumáticas/terapia
Hipopituitarismo/diagnóstico
Hipopituitarismo/terapia
Programas de Rastreamento
[Mh] Termos MeSH secundário: Insuficiência Adrenal/diagnóstico
Insuficiência Adrenal/fisiopatologia
Insuficiência Adrenal/terapia
Adulto
Lesões Encefálicas Traumáticas/fisiopatologia
Diagnóstico Precoce
Intervenção Médica Precoce
Feminino
Seguimentos
Seres Humanos
Hipopituitarismo/fisiopatologia
Síndrome de Secreção Inadequada de HAD/diagnóstico
Síndrome de Secreção Inadequada de HAD/fisiopatologia
Síndrome de Secreção Inadequada de HAD/terapia
Masculino
Admissão do Paciente
Testes de Função Hipofisária
Adeno-Hipófise/fisiopatologia
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2016-315500


  6 / 5725 MEDLINE  
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[PMID]:28780520
[Au] Autor:Silva PPB; Amlashi FG; Yu EW; Pulaski-Liebert KJ; Gerweck AV; Fazeli PK; Lawson E; Nachtigall LB; Biller BMK; Miller KK; Klibanski A; Bouxsein M; Tritos NA
[Ad] Endereço:Neuroendocrine Unit.
[Ti] Título:Bone microarchitecture and estimated bone strength in men with active acromegaly.
[So] Source:Eur J Endocrinol;177(5):409-420, 2017 Nov.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Both acromegaly and adult growth hormone deficiency (GHD) are associated with increased fracture risk. Sufficient data are lacking regarding cortical bone microarchitecture and bone strength, as assessed by microfinite element analysis (µFEA). OBJECTIVE: To elucidate both cortical and trabecular bone microarchitecture and estimated bone strength in men with active acromegaly or GHD compared to healthy controls. DESIGN AND SUBJECTS: Cross-sectional study at a clinical research center, including 48 men (16 with acromegaly, 16 with GHD and 16 healthy controls). OUTCOME MEASURES: Areal bone mineral density (aBMD), cortical and trabecular bone microarchitecture and estimated bone strength (µFEA) at the radius and tibia. RESULTS: aBMD was not different between the 3 groups at any skeletal site. At the radius, patients with acromegaly had greater cortical area ( < 0.0001), cortical thickness ( = 0.0038), cortical pore volume ( < 0.0001) and cortical porosity ( = 0.0008), but lower trabecular bone density ( = 0.0010) compared to controls. At the tibia, patients with acromegaly had lower trabecular bone density ( = 0.0082), but no differences in cortical bone microstructure. Compressive strength and failure load did not significantly differ between groups. These findings persisted after excluding patients with hypogonadism. Bone microarchitecture was not deficient in patients with GHD. CONCLUSIONS: Both cortical and trabecular microarchitecture are altered in men with acromegaly. Our data indicate that GH excess is associated with distinct effects in cortical vs trabecular bone compartments. Our observations also affirm the limitations of aBMD testing in the evaluation of patients with acromegaly.
[Mh] Termos MeSH primário: Acromegalia/diagnóstico por imagem
Densidade Óssea/fisiologia
Rádio (Anatomia)/diagnóstico por imagem
[Mh] Termos MeSH secundário: Absorciometria de Fóton/métodos
Acromegalia/sangue
Adulto
Estudos Transversais
Hormônio do Crescimento Humano/sangue
Seres Humanos
Hipopituitarismo/sangue
Hipopituitarismo/diagnóstico por imagem
Masculino
Meia-Idade
Rádio (Anatomia)/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12629-01-5 (Human Growth Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0468


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[PMID]:28765432
[Au] Autor:Jolobe OMP
[Ad] Endereço:Manchester Medical Society, Manchester, UK.
[Ti] Título:Getting to the heart of hypopituitarism.
[So] Source:Clin Med (Lond);17(4):383-384, 2017 07.
[Is] ISSN:1473-4893
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Coração
Hipopituitarismo
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.7861/clinmedicine.17-4-383


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[PMID]:28693060
[Au] Autor:Wei Q; Zang L; Li YJ; Gu WJ; Jin N; Guo QH; Du J; Ba JM; Lyu ZH; Lu JM; Dou JT; Mu YM; Yang GQ
[Ad] Endereço:Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
[Ti] Título:[An analysis of four cases of misdiagnosed primary lymphocytic hypophysitis].
[So] Source:Zhonghua Nei Ke Za Zhi;56(7):512-515, 2017 Jul 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To improve the differential diagnosis of sellar region mass, 4 cases with sellar mass and misdiagnosed as lymphocytic hypophysitis (LYH) were reviewed retrospectively.The 4 patients (2 male and 2 female) aged 20-60 years old were all presented with symptoms of headache, polydipsia and polyuria.Biochemical studies confirmed the diagnoses of central diabetes insipidus and hypopituitarism.Head MRI scans showed LYH like image for all the cases, and, thus, high dose methylprednisolone pulse therapy (HDMPT) was applied to the patients.Their symptoms deteriorated and the sellar mass enlarged after a short period of partial improvement.Operations were performed in all the patients.Histology study showed craniopharyngioma with abscess, primary abscess, secondary hypophysitis caused by Wegener's granulomatosis, and germinoma with secondary hypophysitis, respectively.In conclusion, surgery or biopsy is necessary for those who presented with sellar region mass and was suspected to be with LYH, but with poor response or even worse after HDMPT.
[Mh] Termos MeSH primário: Diabetes Insípido/complicações
Germinoma/complicações
Hipofisite/complicações
Hipopituitarismo/etiologia
Imagem por Ressonância Magnética
Doenças da Hipófise/etiologia
[Mh] Termos MeSH secundário: Abscesso
Adulto
Biópsia
Feminino
Germinoma/patologia
Cefaleia
Seres Humanos
Hipofisite/diagnóstico
Hipopituitarismo/diagnóstico por imagem
Hipopituitarismo/patologia
Masculino
Meia-Idade
Doenças da Hipófise/diagnóstico por imagem
Doenças da Hipófise/patologia
Estudos Retrospectivos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2017.07.008


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[PMID]:28625907
[Au] Autor:Bertulli L; Bertani GA; Gianelli U; Mantovani G; Rampini PM; Locatelli M
[Ad] Endereço:Unit of Neurosurgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: lorenzo.bertulli@studenti.unimi.it.
[Ti] Título:Long-Standing Isolated Autoimmune Hypothalamitis Diagnosed with Endoscopic Transventricular Biopsy.
[So] Source:World Neurosurg;105:1036.e5-1036.e9, 2017 Sep.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Autoimmune hypothalamitis, which is among the causes of acquired central diabetes insipidus, has seldom been described in the literature. This condition is probably provoked by the production of anti-vasopressin-secreting cell antibodies and antihypothalamus antibodies and is often associated with pituitary or polyendocrine autoimmunity. Correct diagnosis and immediate treatment are essential to avoid the progression of the pathologic process. CASE DESCRIPTION: A woman diagnosed with central diabetes insipidus 12 years ago, who had panhypopituitarism and mild memory deficit, came to our attention. She refused radiologic studies. Magnetic resonance imaging performed in our unit showed a contrast-enhancing hypothalamic lesion. Lumbar puncture was negative for neoplastic markers. We decided to perform a biopsy of the lesion to obtain a histopathologic examination of the tissue and chose an endoscopic transventricular approach to reach the floor of the third ventricle. Autoimmune hypothalamitis was diagnosed and treatment with steroids and azathioprine was started. The lesion size decreased and was stable after 17 months of follow-up. CONCLUSIONS: The endoscopic transventricular approach has proved to be an effective and safe way to obtain tissue samples for histopathologic examination from a region that is usually difficult to reach; it also gives direct visualization of the lesion, which makes sampling easier. The lesion size decreased after treatment but no clinical improvement was detected, either on the cognitive or on the endocrinologic side.
[Mh] Termos MeSH primário: Doenças Autoimunes/diagnóstico
Doenças Autoimunes/cirurgia
Endoscopia/métodos
Doenças Hipotalâmicas/diagnóstico
Doenças Hipotalâmicas/cirurgia
[Mh] Termos MeSH secundário: Idoso
Doenças Autoimunes/complicações
Biópsia
Transtornos Cognitivos/diagnóstico por imagem
Transtornos Cognitivos/etiologia
Diabetes Insípido/fisiopatologia
Feminino
Fluordesoxiglucose F18/farmacocinética
Seres Humanos
Hipopituitarismo/complicações
Hipopituitarismo/diagnóstico por imagem
Hipopituitarismo/etiologia
Doenças Hipotalâmicas/complicações
Antígeno Ki-67/metabolismo
Imagem por Ressonância Magnética
Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ki-67 Antigen); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


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[PMID]:28603206
[Au] Autor:Iwama S; Arima H
[Ad] Endereço:Research Center of Health, Physical Fitness and Sports, Nagoya University.
[Ti] Título:Clinical practice and mechanism of endocrinological adverse events associated with immune checkpoint inhibitors.
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(2):90-94, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Immune checkpoint inhibitors, used for cancer immunotherapy, show anti-tumor effects through T cell activations. Monoclonal antibodies against cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed cell death (PD)-1, or PD-ligand 1 which is a ligand of PD-1 have been shown to be effective in the treatments of advanced cancers including malignant melanoma, non-small cell lung cancer, and renal cell carcinoma. However, these drugs also have immune-related adverse events (irAEs). The irAEs, which have unique characteristics different from those seen in conventional cytotoxic anti-tumor medicines, are observed in the several tissues such as skin, gastrointestinal tract, liver, lung, muscle, nerve and endocrine systems. To safely use immune checkpoint inhibitors, it is quite important to understand the characteristics of irAEs and to manage them in clinical practice. In this review, we focus on clinical characteristics and pathogenesis of adverse events in the pituitary gland.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/efeitos adversos
Doenças da Hipófise/etiologia
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/uso terapêutico
Antígeno CTLA-4/imunologia
Seres Humanos
Hipofisite/etiologia
Hipofisite/terapia
Hipopituitarismo/epidemiologia
Hipopituitarismo/etiologia
Ipilimumab
Neoplasias/tratamento farmacológico
Doenças da Hipófise/terapia
Receptor de Morte Celular Programada 1/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (CTLA-4 Antigen); 0 (Ipilimumab); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 31YO63LBSN (nivolumab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.90



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