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[PMID]:28742093
[Au] Autor:Hermes D; Nguyen M; Winawer J
[Ad] Endereço:Department of Psychology, New York University, New York, New York, United States of America.
[Ti] Título:Neuronal synchrony and the relation between the blood-oxygen-level dependent response and the local field potential.
[So] Source:PLoS Biol;15(7):e2001461, 2017 Jul.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The most widespread measures of human brain activity are the blood-oxygen-level dependent (BOLD) signal and surface field potential. Prior studies report a variety of relationships between these signals. To develop an understanding of how to interpret these signals and the relationship between them, we developed a model of (a) neuronal population responses and (b) transformations from neuronal responses into the functional magnetic resonance imaging (fMRI) BOLD signal and electrocorticographic (ECoG) field potential. Rather than seeking a transformation between the two measures directly, this approach interprets each measure with respect to the underlying neuronal population responses. This model accounts for the relationship between BOLD and ECoG data from human visual cortex in V1, V2, and V3, with the model predictions and data matching in three ways: across stimuli, the BOLD amplitude and ECoG broadband power were positively correlated, the BOLD amplitude and alpha power (8-13 Hz) were negatively correlated, and the BOLD amplitude and narrowband gamma power (30-80 Hz) were uncorrelated. The two measures provide complementary information about human brain activity, and we infer that features of the field potential that are uncorrelated with BOLD arise largely from changes in synchrony, rather than level, of neuronal activity.
[Mh] Termos MeSH primário: Sincronização Cortical
Hipóxia Encefálica/etiologia
Modelos Neurológicos
Potenciais Sinápticos
Córtex Visual/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Algoritmos
Monitorização Transcutânea dos Gases Sanguíneos
Simulação por Computador
Eletrocorticografia
Feminino
Neuroimagem Funcional
Seres Humanos
Hipóxia Encefálica/sangue
Imagem por Ressonância Magnética
Masculino
Neurônios/metabolismo
Oxigênio/sangue
Análise de Componente Principal
Reprodutibilidade dos Testes
Córtex Visual/irrigação sanguínea
Córtex Visual/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001461


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[PMID]:27773345
[Au] Autor:Clay DE; Linke AC; Cameron DJ; Stojanoski B; Rulisa S; Wasunna A; de Ribaupierre S; Cusack R
[Ad] Endereço:Anatomy and Cell Biology, Western University, London, Ontario, Canada.
[Ti] Título:Evaluating Affordable Cranial Ultrasonography in East African Neonatal Intensive Care Units.
[So] Source:Ultrasound Med Biol;43(1):119-128, 2017 01.
[Is] ISSN:1879-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neuroimaging is a valuable diagnostic tool for the early detection of neonatal brain injury, but equipment and radiologic staff are expensive and unavailable to most hospitals in developing countries. We evaluated an affordable, portable ultrasound machine as a quantitative and qualitative diagnostic tool and to establish whether a novice sonographer could effectively operate the equipment and obtain clinically important information. Cranial ultrasonography was performed on term healthy, pre-term and term asphyxiated neonates in Rwandan and Kenyan hospitals. To evaluate the detection of ventriculomegaly and compression injuries, we measured the size of the lateral ventricles and corpus callosum. The images were also assessed for the presence of other cerebral abnormalities. Measurements were reliable across images, and cases of clinically relevant ventriculomegaly were detected. A novice sonographer had good-to-excellent agreement with an expert. This study demonstrates that affordable equipment and cranial ultrasound protocols can be used in low-resource settings to assess the newborn brain.
[Mh] Termos MeSH primário: Lesões Encefálicas/diagnóstico por imagem
Encéfalo/diagnóstico por imagem
Unidades de Terapia Intensiva Neonatal
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Encéfalo/patologia
Lesões Encefálicas/patologia
Feminino
Seres Humanos
Hipóxia Encefálica/diagnóstico por imagem
Recém-Nascido
Masculino
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29207432
[Au] Autor:Hohmann C; Koch KR; Pfister R; Michels G
[Ad] Endereço:Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Köln.
[Ti] Título:[Sonography of the Optic Nerve: a New Bedside Tool in Intensive Care?]
[Ti] Título:Die Sonografie des Sehnervs: ein neues bettseitiges Diagnostikum in der Intensivmedizin?.
[So] Source:Dtsch Med Wochenschr;142(24):1858-1861, 2017 Dec.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Here, we present the case history of a 76-year old man with out-of-hospital cardiac arrest due to a cardiogenic shock and a consecutive no-flow-time of approximately 10 minutes. After 25 minutes of resuscitation procedures a spontaneous return of circulation could be established. The patient was admitted to our center for emergency coronary angiography. After coronary stenting the patient was admitted to our intensive care unit and treated in accordance with the guidelines on cardiogenic shock due to myocardial infarction. After therapeutic hypothermia and subsequent termination of analgosedation a delayed wake-up reaction could be remarked. In the laboratory chemistry the initial parameter of neuron-specific enolase, a marker for cerebral hypoxia, was increased. Measurement of the optic nerve sheath diameter with a maximum diameter of 7 mm indicated an increased intracranial pressure. In the subsequent CT scan of the brain signs of hypoxic encephalopathy with breakup of grey and white matter differentiation were present. In case of clinical and/or laboratory-chemical indications for hypoxic encephalopathy and/or increased intracranial pressure the bedside-based sonography examination at the intensive care unit should imply an evaluation of the optic nerve in order to initiate early apparative neurological diagnostics.
[Mh] Termos MeSH primário: Ecoencefalografia
Parada Cardíaca/complicações
Parada Cardíaca/diagnóstico por imagem
Hipóxia Encefálica/diagnóstico por imagem
Unidades de Terapia Intensiva
Hipertensão Intracraniana/diagnóstico por imagem
Nervo Óptico/diagnóstico por imagem
Testes Imediatos
Choque Cardiogênico/complicações
Choque Cardiogênico/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Reanimação Cardiopulmonar
Parada Cardíaca/terapia
Seres Humanos
Masculino
Sensibilidade e Especificidade
Choque Cardiogênico/terapia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-121607


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[PMID]:28753456
[Au] Autor:Ruijter BJ; Hofmeijer J; Meijer HGE; van Putten MJAM
[Ad] Endereço:Clinical Neurophysiology, MIRA - Institute for Biomedical Technology and Technical Medicine, University of Twente, Hallenweg 15, 7522NB Enschede, The Netherlands. Electronic address: b.j.ruijter@utwente.nl.
[Ti] Título:Synaptic damage underlies EEG abnormalities in postanoxic encephalopathy: A computational study.
[So] Source:Clin Neurophysiol;128(9):1682-1695, 2017 Sep.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In postanoxic coma, EEG patterns indicate the severity of encephalopathy and typically evolve in time. We aim to improve the understanding of pathophysiological mechanisms underlying these EEG abnormalities. METHODS: We used a mean field model comprising excitatory and inhibitory neurons, local synaptic connections, and input from thalamic afferents. Anoxic damage is modeled as aggravated short-term synaptic depression, with gradual recovery over many hours. Additionally, excitatory neurotransmission is potentiated, scaling with the severity of anoxic encephalopathy. Simulations were compared with continuous EEG recordings of 155 comatose patients after cardiac arrest. RESULTS: The simulations agree well with six common categories of EEG rhythms in postanoxic encephalopathy, including typical transitions in time. Plausible results were only obtained if excitatory synapses were more severely affected by short-term synaptic depression than inhibitory synapses. CONCLUSIONS: In postanoxic encephalopathy, the evolution of EEG patterns presumably results from gradual improvement of complete synaptic failure, where excitatory synapses are more severely affected than inhibitory synapses. The range of EEG patterns depends on the excitation-inhibition imbalance, probably resulting from long-term potentiation of excitatory neurotransmission. SIGNIFICANCE: Our study is the first to relate microscopic synaptic dynamics in anoxic brain injury to both typical EEG observations and their evolution in time.
[Mh] Termos MeSH primário: Coma/fisiopatologia
Eletroencefalografia/tendências
Parada Cardíaca/fisiopatologia
Hipóxia Encefálica/fisiopatologia
Redes Neurais (Computação)
Sinapses/fisiologia
[Mh] Termos MeSH secundário: Idoso
Coma/diagnóstico
Coma/epidemiologia
Feminino
Parada Cardíaca/diagnóstico
Parada Cardíaca/epidemiologia
Seres Humanos
Hipóxia Encefálica/diagnóstico
Hipóxia Encefálica/epidemiologia
Potenciação de Longa Duração/fisiologia
Masculino
Potenciais da Membrana/fisiologia
Meia-Idade
Países Baixos/epidemiologia
Transmissão Sináptica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE


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[PMID]:28632329
[Au] Autor:Farrell JS; Colangeli R; Wolff MD; Wall AK; Phillips TJ; George A; Federico P; Teskey GC
[Ad] Endereço:Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
[Ti] Título:Postictal hypoperfusion/hypoxia provides the foundation for a unified theory of seizure-induced brain abnormalities and behavioral dysfunction.
[So] Source:Epilepsia;58(9):1493-1501, 2017 Sep.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A recent article by Farrell et al. characterizes the phenomenon, mechanisms, and treatment of a local and severe hypoperfusion/hypoxia event that occurs in brain regions following a focal seizure. Given the well-established role of cerebral ischemia/hypoxia in brain damage and behavioral dysfunction in other clinical settings (e.g., stroke, cerebral vasospasm), we put forward a new theory: postictal hypoperfusion/hypoxia is responsible for the negative consequences associated with seizures. Fortunately, inhibition of two separate molecular targets, cyclooxygenase-2 (COX-2) and l-type calcium channels, can prevent the expression of postictal hypoperfusion/hypoxia. These inhibitors are important experimental tools used to separate the seizure from the resulting hypoperfusion/hypoxia and can allow researchers to address the contribution of this phenomenon to negative outcomes associated with seizures. Herein we address the implications of this postictal stroke-like event in acute behavioral dysfunction (e.g., Todd's paresis) and sudden unexpected death in epilepsy (SUDEP). Moreover, anatomic alterations such as increased blood-brain barrier permeability, glial activation, central inflammation, and neuronal loss could also be a consequence of repeated hypoperfusion/hypoxic events and, in turn, underlie chronic interictal cognitive and behavioral comorbidities (e.g., memory deficits, anxiety, depression, and psychosis) and exacerbate epileptogenesis. Thus these seemingly disparate and clinically important observations may share a common point of origin: postictal hypoperfusion/hypoxia.
[Mh] Termos MeSH primário: Hipóxia Encefálica/fisiopatologia
Convulsões/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/irrigação sanguínea
Encéfalo/fisiopatologia
Canais de Cálcio Tipo L/metabolismo
Ciclo-Oxigenase 2/metabolismo
Seres Humanos
Modelos Biológicos
Convulsões/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Channels, L-Type); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13827


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[PMID]:28542925
[Au] Autor:Nathaniel TI; Stewart B; Williams J; Hood M; Imeh-Nathaniel A
[Ad] Endereço:University of South Carolina School of Medicine, Greenville, SC, USA.
[Ti] Título:A new insight into the ability to resist Ischemic brain injury: Does hibernation matter?: An Editorial comment for 'Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux'.
[So] Source:J Neurochem;142(1):10-13, 2017 Jul.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Read the commented article 'Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis and glutamate efflux' on doi: 10.1111/jnc.13996.
[Mh] Termos MeSH primário: Isquemia Encefálica/fisiopatologia
Glucose/deficiência
Hibernação/fisiologia
Hipocampo/fisiopatologia
Hipóxia Encefálica/fisiopatologia
Sciuridae/fisiologia
[Mh] Termos MeSH secundário: Acidose/fisiopatologia
Trifosfato de Adenosina/metabolismo
Animais
Ácido Glutâmico/metabolismo
Hipocampo/metabolismo
Estações do Ano
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
3KX376GY7L (Glutamic Acid); 8L70Q75FXE (Adenosine Triphosphate); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14022


  7 / 6475 MEDLINE  
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[PMID]:28407001
[Au] Autor:Ruzafa N; Rey-Santano C; Mielgo V; Pereiro X; Vecino E
[Ad] Endereço:Department of Cell Biology and Histology, University of Basque Country UPV/EHU, Leioa, Vizcaya, Spain.
[Ti] Título:Effect of hypoxia on the retina and superior colliculus of neonatal pigs.
[So] Source:PLoS One;12(4):e0175301, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effect of hypoxia on the neonatal pig retina and brain, we analysed the retinal ganglion cells (RGCs) and neurons in the superior colliculus, as well as the response of astrocytes in both these central nervous system (CNS) structures. METHODS: Newborn pigs were exposed to 120 minutes of hypoxia, induced by decreasing the inspiratory oxygen fraction (FiO2: 10-15%), followed by a reoxygenation period of 240 minutes (FiO2: 21-35%). RGCs were quantified using Brn3a, a specific nuclear marker for these cells, and apoptosis was assessed through the appearance of active caspase-3. A morphometric analysis of the cytoskeleton of astrocytes (identified with GFAP) was performed in both the retina and superior colliculus. RESULTS: Hypoxia produced no significant change in the RGCs, although, it did induce a 37.63% increase in the number of active caspase-3 positive cells in the superior colliculus. This increase was particularly evident in the superficial layers of the superior colliculus, where 56.93% of the cells were positive for active caspase-3. In addition, hypoxia induced changes in the morphology of the astrocytes in the superior colliculus but not in the retina. CONCLUSIONS: Hypoxia in the neonatal pig does not affect the retina but it does affect more central structures in the brain, increasing the number of apoptotic cells in the superior colliculus and inducing changes in astrocyte morphology. This distinct sensibility to hypoxia may pave the way to design specific approaches to combat the effects of hypoxia in specific areas of the CNS.
[Mh] Termos MeSH primário: Apoptose
Astrócitos/metabolismo
Hipóxia Encefálica/metabolismo
Hipóxia/metabolismo
Células Ganglionares da Retina/metabolismo
Colículos Superiores/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Astrócitos/patologia
Caspase 3/biossíntese
Hipóxia/patologia
Hipóxia Encefálica/patologia
Células Ganglionares da Retina/patologia
Colículos Superiores/irrigação sanguínea
Colículos Superiores/patologia
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175301


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[PMID]:28328980
[Au] Autor:Plomgaard AM; Alderliesten T; Austin T; van Bel F; Benders M; Claris O; Dempsey E; Fumagalli M; Gluud C; Hagmann C; Hyttel-Sorensen S; Lemmers P; van Oeveren W; Pellicer A; Petersen TH; Pichler G; Winkel P; Greisen G
[Ad] Endereço:Department of Neonatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
[Ti] Título:Early biomarkers of brain injury and cerebral hypo- and hyperoxia in the SafeBoosC II trial.
[So] Source:PLoS One;12(3):e0173440, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The randomized clinical trial, SafeBoosC II, examined the effect of monitoring of cerebral oxygenation by near-infrared spectroscopy combined with a guideline on treatment when cerebral oxygenation was out of the target range. Data on cerebral oxygenation was collected in both the intervention and the control group. The primary outcome was the reduction in the burden of cerebral hypo- and hyperoxia between the two groups. In this study we describe the associations between the burden of cerebral hypo- and hyperoxia, regardless of allocation to intervention or control group, and the biomarkers of brain injury from birth till term equivalent age that was collected as secondary and explorative outcomes in the SafeBoosC II trial. METHODS: Cerebral oxygenation was continuously monitored during the first 72h of life in 166 extremely preterm infants. Cranial ultrasound was performed at day 1,4,7,14, and 35 and at term. Electroencephalogram (EEG) was recorded at 64h. Blood-samples taken at 6 and 64 hours were analysed for the brain injury biomarkers; S100beta, brain-fatty-acid-binding-protein, and neuroketal. All analyses were conducted post hoc. RESULTS: Significantly more infants with a cerebral burden of hypoxia within the 4th quartile versus infants within quartile 1-3 were diagnosed with severe intracranial haemorrhage (11/39 versus 11/117, p = 0.003), had low burst rate on EEG (12/28 versus 21/103, p = 0.015), or died (14/41 versus 18/123, p = 0.006), whereas none of these events were significantly associated with cerebral hyperoxia. The blood biomarkers were not significantly associated with the burden of cerebral hypo- or hyperoxia. CONCLUSIONS: The explorative analysis showed that early burden of cerebral hypoxia, but not hyperoxia was significantly associated with low brain electrical activity and severe intracranial haemorrhage while none of the three blood biomarkers were associated with the burden of either cerebral hypo- or hyperoxia.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Lesões Encefálicas/diagnóstico
Lesões Encefálicas/metabolismo
Hiperóxia/diagnóstico
Hiperóxia/metabolismo
Hipóxia Encefálica/diagnóstico
Hipóxia Encefálica/metabolismo
[Mh] Termos MeSH secundário: Eletroencefalografia/métodos
Feminino
Idade Gestacional
Seres Humanos
Lactente Extremamente Prematuro/metabolismo
Recém-Nascido
Masculino
Monitorização Fisiológica/métodos
Oximetria/métodos
Oxigênio/metabolismo
Espectroscopia de Luz Próxima ao Infravermelho/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173440


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[PMID]:28245682
[Au] Autor:Kovács K; Szakmár E; Méder Ü; Kolossváry M; Bagyura Z; Lamboy L; Élo Z; Szabó A; Szabó M; Jermendy Á
[Ad] Endereço:I. Gyermekgyógyászati Klinika, Újszülött Intenzív Osztály, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Bókay János u. 53-54., 1083.
[Ti] Título:[Hypothermia treatment in asphyxiated neonates - a single center experience in Hungary].
[Ti] Título:Terápiás hypothermia alkalmazása az asphyxiás újszülöttek kezelésében ­ egy hazai neonatológiai centrum eredményei..
[So] Source:Orv Hetil;158(9):331-339, 2017 Mar.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:INTRODUCTION AND AIM: We aimed to analyze patient characteristics of term neonates with hypoxic-ischemic encephalopathy treated with hypothermia at the 3rd level Neonatal Intensive Care Unit of the 1st Department of Pediatrics, Semmelweis University. METHOD: We conducted a retrospective cohort analysis between 2013-2015, including 97 asphyxiated neonates with HIE who received hypothermia treatment, using our in-house developed novel registry database. RESULTS: 59.8% of neonates were born with Cesarean section and the first blood gas analysis showed a pH of 7.0 ± 0.2, pCO 55.9 ± 27.3 mmHg, base deficit 16.7 ± 7.2 mmol/l, and lactate levels of 13.3 ± 4.7 mmol/l (x ± SD). Hypothermia treatment was started during neonatal transport in 93.7% of the cases, at 2.5 ± 0.3 hours of age. Multiorgan failure associated with the perinatal asphyxia was present in 83.2% of the patients. Patients received intensive therapy for a median of 10.8 days, 61.3% of neonates were discharged home directly, 32.2% required further hospital treatment, and 6.5% died. CONCLUSION: Our novel registry database allowed for a quick, user-friendly and time-efficient analysis of patient characteristics in neonates with HIE. This registry could aid institutional audit work and prospective clinical data collection. Orv. Hetil., 2017, 158(9), 331-339.
[Mh] Termos MeSH primário: Asfixia Neonatal/terapia
Hipotermia Induzida/métodos
Hipóxia Encefálica/prevenção & controle
[Mh] Termos MeSH secundário: Índice de Apgar
Estudos de Coortes
Feminino
Idade Gestacional
Seres Humanos
Hungria
Recém-Nascido
Unidades de Terapia Intensiva Neonatal
Masculino
Oxigênio/uso terapêutico
Estudos Retrospectivos
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30661


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[PMID]:28228417
[Au] Autor:Jung S; Boie G; Doerr HG; Trollmann R
[Ad] Endereço:Division of Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; and.
[Ti] Título:Oxygen-sensitive regulation and neuroprotective effects of growth hormone-dependent growth factors during early postnatal development.
[So] Source:Am J Physiol Regul Integr Comp Physiol;312(4):R539-R548, 2017 Apr 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perinatal hypoxia severely disrupts metabolic and somatotrophic development, as well as cerebral maturational programs. Hypoxia-inducible transcription factors (HIFs) represent the most important endogenous adaptive mechanisms to hypoxia, activating a broad spectrum of growth factors that contribute to cell survival and energy homeostasis. To analyze effects of systemic hypoxia and growth hormone (GH) therapy (rhGH) on HIF-dependent growth factors during early postnatal development, we compared protein (using ELISA) and mRNA (using quantitative RT PCR) levels of growth factors in plasma and brain between normoxic and hypoxic mice (8% O , 6 h; postnatal , P7) at P14. Exposure to hypoxia led to reduced body weight ( < 0.001) and length ( < 0.04) compared with controls and was associated with significantly reduced plasma levels of mouse GH ( < 0.01) and IGF-1 ( < 0.01). RhGH abrogated these hypoxia-induced changes of the GH/IGF-1 axis associated with normalization of weight and length gain until P14 compared with controls. In addition, rhGH treatment increased cerebral IGF-1, IGF-2, IGFBP-2, and erythropoietin mRNA levels, resulting in significantly reduced apoptotic cell death in the hypoxic, developing mouse brain. These data indicate that rhGH may functionally restore hypoxia-induced systemic dysregulation of the GH/IGF-1 axis and induce upregulation of neuroprotective, HIF-dependent growth factors in the hypoxic developing brain.
[Mh] Termos MeSH primário: Envelhecimento/metabolismo
Hormônio do Crescimento/administração & dosagem
Hipóxia Encefálica/tratamento farmacológico
Hipóxia Encefálica/metabolismo
Peptídeos e Proteínas de Sinalização Intercelular/administração & dosagem
Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Envelhecimento/efeitos dos fármacos
Animais
Animais Recém-Nascidos
Feminino
Hormônio do Crescimento/metabolismo
Hormônio do Crescimento Humano/administração & dosagem
Hipóxia
Peptídeos e Proteínas de Sinalização Intercelular/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Fármacos Neuroprotetores/administração & dosagem
Fármacos Neuroprotetores/metabolismo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Intercellular Signaling Peptides and Proteins); 0 (Neuroprotective Agents); 12629-01-5 (Human Growth Hormone); 9002-72-6 (Growth Hormone); S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00477.2016



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