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[PMID]:29343683
[Au] Autor:Meng X; Grötsch B; Luo Y; Knaup KX; Wiesener MS; Chen XX; Jantsch J; Fillatreau S; Schett G; Bozec A
[Ad] Endereço:Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91054, Erlangen, Germany.
[Ti] Título:Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.
[So] Source:Nat Commun;9(1):251, 2018 01 17.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in B lymphocytes are poorly defined. Here, we show that hypoxia-inducible factor-1α (HIF-1α) contributes to IL-10 production by B cells. HIF-1α regulates IL-10 expression, and HIF-1α-dependent glycolysis facilitates CD1d CD5 B cells expansion. Mice with B cell-specific deletion of Hif1a have reduced number of IL-10-producing B cells, which result in exacerbated collagen-induced arthritis and experimental autoimmune encephalomyelitis. Wild-type CD1d CD5 B cells, but not Hif1a-deficient CD1d CD5 B cells, protect recipient mice from autoimmune disease, while the protective function of Hif1a-deficient CD1d CD5 B cells is restored when their defective IL-10 expression is genetically corrected. Taken together, this study demonstrates the key function of the hypoxia-associated transcription factor HIF-1α in driving IL-10 expression in CD1d CD5 B cells, and in controlling their protective activity in autoimmune disease.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Linfócitos B/metabolismo
Subunidade alfa do Fator 1 Induzível por Hipóxia/fisiologia
Interleucina-10/metabolismo
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/imunologia
Artrite Experimental/metabolismo
Doenças Autoimunes/metabolismo
Encefalomielite/imunologia
Encefalomielite/metabolismo
Subunidade alfa do Fator 1 Induzível por Hipóxia/genética
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoxia-Inducible Factor 1, alpha Subunit); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02683-x


  2 / 2337 MEDLINE  
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[PMID]:28697873
[Au] Autor:James KE; Smith WA; Packham AE; Conrad PA; Pusterla N
[Ad] Endereço:Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, CA, 95616, USA. Electronic address: kjames@ucdavis.edu.
[Ti] Título:Toxoplasma gondii seroprevalence and association with equine protozoal myeloencephalitis: A case-control study of Californian horses.
[So] Source:Vet J;224:38-43, 2017 Jun.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:While toxoplasmosis is not commonly considered a clinical disease of equines, previous seroprevalence studies have reported differing background rates of Toxoplasma gondii infection in horses globally. The objective of this study was to evaluate possible associations between T. gondii seroprevalence and clinical signs of equine protozoal myeloencephalitis (EPM) in horses. Using a case-control study design, 720 Californian horses with neurologic signs compatible with EPM were compared to healthy, non-neurologic horses for the presence of T. gondii antibodies (using indirect fluorescent antibody tests [IFAT]). Toxoplasma gondii seroprevalence among cases and controls was determined at standard serum cut-offs: 40, 80, 160, 320, and 640. At a T. gondii titre cut-off of 320, horses with clinical signs compatible with EPM had 3.55 times the odds of a seropositive test compared to those without clinical signs (P<0.01) when adjusted for covariates. When restricted to the autumn season and at the same titre cut-off, an EPM suspect horse had 6.4 times the odds of testing seropositive to T. gondii, compared to non-neurologic horses. The association between high T. gondii titres and clinical signs compatible with EPM is potentially reflective of toxoplasmosis in equines. Serologic testing of cerebrospinal fluid and isolation of T. gondii in EPM suspect cases should be considered. Future studies investigating the relationship between T. gondii and EPM are warranted.
[Mh] Termos MeSH primário: Anticorpos Antiprotozoários/sangue
Encefalomielite/veterinária
Doenças dos Cavalos/parasitologia
Toxoplasma/imunologia
Toxoplasmose Animal/epidemiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antiprotozoários/líquido cefalorraquidiano
California/epidemiologia
Estudos de Casos e Controles
Encefalomielite/parasitologia
Feminino
Técnica Indireta de Fluorescência para Anticorpo/veterinária
Cavalos
Masculino
Estações do Ano
Estudos Soroepidemiológicos
Toxoplasma/isolamento & purificação
Toxoplasmose Animal/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


  3 / 2337 MEDLINE  
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[PMID]:28684423
[Au] Autor:Chen J; Martindale JL; Cramer C; Gorospe M; Atasoy U; Drew PD; Yu S
[Ad] Endereço:From the Arkansas Biosciences Institute, Department of Biological Sciences, Arkansas State University, Jonesboro, Arkansas 72467, jing.chen@jefferson.edu.
[Ti] Título:The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.
[So] Source:J Biol Chem;292(35):14532-14543, 2017 Sep 01.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS). Whereas many cytokines and their receptors are potently regulated via post-transcriptional mechanisms in response to various stimuli, how CCR6 expression is post-transcriptionally regulated in Th17 cells is unknown. Here, using RNA-binding protein HuR conditional knock-out (KO) and wild-type (WT) mice, we present evidence that HuR post-transcriptionally regulates CCR6 expression by binding to and stabilizing mRNA and by promoting CCR6 translation. We also found that HuR down-regulates several microRNA expressions, which could target the 3'-UTR of Ccr6 mRNA for decay. Accordingly, knock-out of HuR reduced CCR6 expression on Th17 cells and impaired their migration to CNS compared with the response of WT Th17 cells and thereby ameliorated EAE. Together, these findings highlight how HuR contributes to Th17 cell-mediated autoimmune neuroinflammation and support the notion that targeting HuR might be a potential therapeutic intervention for managing autoimmune disorders of the CNS.
[Mh] Termos MeSH primário: Proteína Semelhante a ELAV 1/metabolismo
Regulação da Expressão Gênica
RNA Mensageiro/metabolismo
Receptores CCR6/agonistas
Linfócitos T Auxiliares-Indutores/metabolismo
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas
Animais
Doenças Autoimunes do Sistema Nervoso/imunologia
Doenças Autoimunes do Sistema Nervoso/metabolismo
Doenças Autoimunes do Sistema Nervoso/patologia
Linhagem Celular
Movimento Celular
Células Cultivadas
Sistema Nervoso Central/imunologia
Sistema Nervoso Central/metabolismo
Sistema Nervoso Central/patologia
Proteína Semelhante a ELAV 1/antagonistas & inibidores
Proteína Semelhante a ELAV 1/genética
Encefalomielite/imunologia
Encefalomielite/metabolismo
Encefalomielite/patologia
Seres Humanos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Camundongos Transgênicos
MicroRNAs/metabolismo
Biossíntese de Proteínas
Interferência de RNA
Estabilidade de RNA
Receptores CCR6/antagonistas & inibidores
Receptores CCR6/genética
Receptores CCR6/metabolismo
Linfócitos T Auxiliares-Indutores/citologia
Linfócitos T Auxiliares-Indutores/imunologia
Linfócitos T Auxiliares-Indutores/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (CCR6 protein, mouse); 0 (ELAV-Like Protein 1); 0 (ELAVL1 protein, human); 0 (Elavl1 protein, mouse); 0 (MicroRNAs); 0 (RNA, Messenger); 0 (Receptors, CCR6)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.782771


  4 / 2337 MEDLINE  
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[PMID]:28615429
[Au] Autor:Hacohen Y; Mankad K; Chong WK; Barkhof F; Vincent A; Lim M; Wassmer E; Ciccarelli O; Hemingway C
[Ad] Endereço:From the Department of Paediatric Neurology (Y.H., C.H.), Great Ormond Street Hospital for Children; Department of Neuroinflammation (Y.H., O.C.), Queen Square MS Centre, UCL Institute of Neurology; Department of Clinical Neuroscience (Y.H.), UCL Institute of Child Health; Paediatric Neuroradiology
[Ti] Título:Diagnostic algorithm for relapsing acquired demyelinating syndromes in children.
[So] Source:Neurology;89(3):269-278, 2017 Jul 18.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To establish whether children with relapsing acquired demyelinating syndromes (RDS) and myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) show distinctive clinical and radiologic features and to generate a diagnostic algorithm for the main RDS for clinical use. METHODS: A panel reviewed the clinical characteristics, MOG-Ab and aquaporin-4 (AQP4) Ab, intrathecal oligoclonal bands, and Epstein-Barr virus serology results of 110 children with RDS. A neuroradiologist blinded to the diagnosis scored the MRI scans. Clinical, radiologic, and serologic tests results were compared. RESULTS: The findings showed that 56.4% of children were diagnosed with multiple sclerosis (MS), 25.4% with neuromyelitis optica spectrum disorder (NMOSD), 12.7% with multiphasic disseminated encephalomyelitis (MDEM), and 5.5% with relapsing optic neuritis (RON). Blinded analysis defined baseline MRI as typical of MS in 93.5% of children with MS. Acute disseminated encephalomyelitis presentation was seen only in the non-MS group. Of NMOSD cases, 30.7% were AQP4-Ab positive. MOG-Ab were found in 83.3% of AQP4-Ab-negative NMOSD, 100% of MDEM, and 33.3% of RON. Children with MOG-Ab were younger, were less likely to present with area postrema syndrome, and had lower disability, longer time to relapse, and more cerebellar peduncle lesions than children with AQP4-Ab NMOSD. A diagnostic algorithm applicable to any episode of CNS demyelination leads to 4 main phenotypes: MS, AQP4-Ab NMOSD, MOG-Ab-associated disease, and antibody-negative RDS. CONCLUSIONS: Children with MS and AQP4-Ab NMOSD showed features typical of adult cases. Because MOG-Ab-positive children showed notable and distinctive clinical and MRI features, they were grouped into a unified phenotype (MOG-Ab-associated disease), included in a new diagnostic algorithm.
[Mh] Termos MeSH primário: Algoritmos
Tomada de Decisão Clínica
Encefalomielite/diagnóstico
Esclerose Múltipla/diagnóstico por imagem
Neuromielite Óptica/diagnóstico
Neurite Óptica/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Aquaporina 4/imunologia
Autoanticorpos/sangue
Encéfalo/diagnóstico por imagem
Criança
Pré-Escolar
Encefalomielite/sangue
Encefalomielite/diagnóstico por imagem
Encefalomielite/imunologia
Feminino
Seguimentos
Herpesvirus Humano 4
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Esclerose Múltipla/sangue
Esclerose Múltipla/imunologia
Glicoproteína Mielina-Oligodendrócito/imunologia
Neuromielite Óptica/sangue
Neuromielite Óptica/diagnóstico por imagem
Neuromielite Óptica/imunologia
Bandas Oligoclonais
Neurite Óptica/sangue
Neurite Óptica/diagnóstico por imagem
Neurite Óptica/imunologia
Recidiva
Estudos Retrospectivos
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aquaporin 4); 0 (Autoantibodies); 0 (MOG protein, human); 0 (Myelin-Oligodendrocyte Glycoprotein); 0 (Oligoclonal Bands)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004117


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[PMID]:28531865
[Au] Autor:Baxter VK; Glowinski R; Braxton AM; Potter MC; Slusher BS; Griffin DE
[Ad] Endereço:W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: vkbaxter
[Ti] Título:Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis.
[So] Source:Virology;508:134-149, 2017 Aug.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Infection of weanling C57BL/6 mice with the TE strain of Sindbis virus (SINV) causes nonfatal encephalomyelitis associated with hippocampal-based memory impairment that is partially prevented by treatment with 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist (Potter et al., J Neurovirol 21:159, 2015). To determine the mechanism(s) of protection, lymph node and central nervous system (CNS) tissues from SINV-infected mice treated daily for 1 week with low (0.3mg/kg) or high (0.6mg/kg) dose DON were examined. DON treatment suppressed lymphocyte proliferation in cervical lymph nodes resulting in reduced CNS immune cell infiltration, inflammation, and cell death compared to untreated SINV-infected mice. Production of SINV-specific antibody and interferon-gamma were also impaired by DON treatment with a delay in virus clearance. Cessation of treatment allowed activation of the antiviral immune response and viral clearance, but revived CNS pathology, demonstrating the ability of the immune response to mediate both CNS damage and virus clearance.
[Mh] Termos MeSH primário: Infecções por Alphavirus/tratamento farmacológico
Infecções por Alphavirus/imunologia
Antivirais/administração & dosagem
Diazo-Oxo-Norleucina/administração & dosagem
Encefalomielite/tratamento farmacológico
Encefalomielite/imunologia
Glutamina/antagonistas & inibidores
Vírus Sindbis/fisiologia
[Mh] Termos MeSH secundário: Infecções por Alphavirus/patologia
Infecções por Alphavirus/virologia
Animais
Encefalomielite/patologia
Encefalomielite/virologia
Seres Humanos
Interferon gama/genética
Interferon gama/imunologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Vírus Sindbis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 03J0H273KZ (Diazooxonorleucine); 0RH81L854J (Glutamine); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


  6 / 2337 MEDLINE  
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[PMID]:28509641
[Au] Autor:James KE; Smith WA; Conrad PA; Packham AE; Guerrero L; Ng M; Pusterla N
[Ti] Título:Seroprevalences of anti-Sarcocystis neurona and anti-Neospora hughesi antibodies among healthy equids in the United States.
[So] Source:J Am Vet Med Assoc;250(11):1291-1301, 2017 Jun 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To describe the general seroprevalence of anti-Sarcocystis neurona and anti-Neospora hughesi antibodies among healthy equids by use of indirect fluorescent antibody tests and determine potential risk factors for seropositivity. DESIGN Cross-sectional study. SAMPLE Whole blood samples collected from 5,250 equids (1 sample/animal) across 18 states in the United States during October 2013. PROCEDURES Information regarding potential risk factors (geographic region, breed, primary use, sex, and age) was collected along with the blood samples. For each equid, an indirect fluorescent antibody test was used to determine serum titers of antibody against each of the 2 protozoal parasites. Mixed-effects logistic regression models were created to determine ORs for seropositivity. RESULTS The overall seroprevalence of anti-S neurona and anti-N hughesi antibodies in the tested equids was 78% and 34%, respectively. Of the equids, 31% were seropositive and 18% were seronegative for antibodies against both parasites. Factors associated with equids being seropositive for anti-S neurona antibodies were residence in the South, warmblood breed, and age > 5 years. Seroprevalence of anti-N hughesi antibodies did not differ among equids in different states across the country, but warmblood breed and age > 5 years were associated with seropositivity. CONCLUSIONS AND CLINICAL RELEVANCE With regard to risk factors for S neurona and N hughesi exposure and antibody response among tested equids, older age was not unexpected; however, the influences of warmblood breed and geographic location on seropositivity for anti-S neurona antibody but not for anti-N hughesi antibody deserve further investigation.
[Mh] Termos MeSH primário: Coccidiose/veterinária
Encefalomielite/veterinária
Doenças dos Cavalos/epidemiologia
Neospora/isolamento & purificação
Sarcocystis/isolamento & purificação
Sarcocistose/veterinária
[Mh] Termos MeSH secundário: Animais
Anticorpos Antiprotozoários/sangue
Coccidiose/epidemiologia
Coccidiose/parasitologia
Estudos Transversais
Encefalomielite/epidemiologia
Encefalomielite/parasitologia
Feminino
Doenças dos Cavalos/sangue
Doenças dos Cavalos/parasitologia
Cavalos
Masculino
Neospora/imunologia
Prevalência
Fatores de Risco
Sarcocystis/imunologia
Sarcocistose/epidemiologia
Sarcocistose/parasitologia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Protozoan)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.11.1291


  7 / 2337 MEDLINE  
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[PMID]:28363039
[Au] Autor:Edwards EE; Dangoudoubiyam S; Hoppes SM; Porter BF
[Ti] Título:GRANULOMATOUS FILARIAL ENCEPHALOMYELITIS CAUSED BY CHANDLERELLA QUISCALI IN A NORTHERN CRESTED CARACARA (CARACARA CHERIWAY).
[So] Source:J Zoo Wildl Med;48(1):237-240, 2017 Mar.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A northern crested caracara (Caracara cheriway) was presented after being found nonambulatory in a field. On physical examination, the bird had severe hind-limb paresis. The bird did not improve after 10 days of hospitalization and was euthanized. Histologic examination of the cerebrum and spinal cord revealed multiple adult filarial nematodes surrounded by granulomatous inflammation with several multinucleated giant cells. These parasites were confirmed to be Chandlerella quiscali with polymerase chain reaction. This is the first report of C. quiscali in a bird of prey.
[Mh] Termos MeSH primário: Doenças das Aves/parasitologia
Helmintíase do Sistema Nervoso Central/veterinária
Encefalomielite/veterinária
Falconiformes
Filariose/veterinária
Filarioidea/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Helmintíase do Sistema Nervoso Central/parasitologia
Helmintíase do Sistema Nervoso Central/patologia
Filariose/parasitologia
Filarioidea/classificação
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1638/2016-0123.1


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[PMID]:28325183
[Au] Autor:Maxwell LK
[Ad] Endereço:Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74078, USA. Electronic address: lk.maxwell@okstate.edu.
[Ti] Título:Antiherpetic Drugs in Equine Medicine.
[So] Source:Vet Clin North Am Equine Pract;33(1):99-125, 2017 Apr.
[Is] ISSN:1558-4224
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since vaccination may not prevent disease, antiherpetic drugs have been investigated for the therapy of several equine herpesviruses. Drug efficacy has been assessed in horses with disease, but most evidence is in vitro, in other species, or empirical. Oral valacyclovir is most often administered in the therapy of equine herpesvirus type-1 (EHV-1) to protect adult horses from equine herpesvirus myeloencephalopathy, while oral acyclovir is frequently administered for EHV-5 infection in the therapy of equine multinodular pulmonary fibrosis. Other antiherpetic drugs are promising but require further investigation. Several topical drugs are also empirically used in the therapy of equine viral keratitis.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Infecções por Herpesviridae/veterinária
Doenças dos Cavalos/tratamento farmacológico
Doenças dos Cavalos/virologia
[Mh] Termos MeSH secundário: Animais
Encefalomielite/tratamento farmacológico
Encefalomielite/veterinária
Encefalomielite/virologia
Infecções por Herpesviridae/tratamento farmacológico
Herpesvirus Equídeo 1/isolamento & purificação
Cavalos
Fibrose Pulmonar/tratamento farmacológico
Fibrose Pulmonar/veterinária
Fibrose Pulmonar/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiviral Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28267222
[Au] Autor:Cornelis I; Volk HA; Van Ham L; De Decker S
[Ad] Endereço:Clinical Science and Services, The Royal Veterinary College, University of London, Hatfield, Hertfordshire, AL97TA, UK.
[Ti] Título:Clinical presentation, diagnostic findings and outcome in dogs diagnosed withpresumptive spinal-only meningoen-cephalomyelitis of unknown origin.
[So] Source:J Small Anim Pract;58(3):174-182, 2017 Mar.
[Is] ISSN:1748-5827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone. METHODS: Medical records were reviewed for dogs diagnosed with presumptive spinal-only meningoencephalomyelitis of unknown origin between 2006 and 2015. RESULTS: 21 dogs were included; the majority presented with an acute (43%) or chronic (52%) onset of neurological signs. Ambulatory paresis was the most common neurological presentation (67%). Neurological examination most commonly revealed a T3-L3 myelopathy, and spinal hyperaesthesia was a common finding (71%). A spinal cord lesion was visible in 90% of cases on magnetic resonance imaging. Eighteen lesions (86%) showed parenchymal contrast enhancement and 17 lesions (81%) showed contrast enhancement of overlying meninges. All dogs were treated with immunosuppressive doses of glucocorticosteroids, sometimes combined with cytosine arabinoside. At time of data capture, 10/21 dogs (48%) had died or been euthanased because of the condition. Overall median survival time was 669 days. CLINICAL SIGNIFICANCE: Meningoencephalomyelitis of unknown origin should be considered in the differential diagnosis of dogs presenting with a progressive myelopathy. Magnetic resonance imaging features can possibly help to distinguish presumptive meningoencephalomyelitis of unknown origin from other more common spinal diseases. Overall, long-term survival is guarded, approximately 50% of dogs will die or be euthanased despite appropriate therapy.
[Mh] Termos MeSH primário: Doenças do Cão/diagnóstico
Encefalomielite/veterinária
Meningoencefalite/veterinária
Doenças da Medula Espinal/veterinária
Medula Espinal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Animais
Citarabina/uso terapêutico
Doenças do Cão/tratamento farmacológico
Cães
Encefalomielite/diagnóstico
Encefalomielite/tratamento farmacológico
Feminino
Glucocorticoides/uso terapêutico
Imunossupressores/uso terapêutico
Imagem por Ressonância Magnética/veterinária
Masculino
Meningoencefalite/diagnóstico
Meningoencefalite/tratamento farmacológico
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Immunosuppressive Agents); 04079A1RDZ (Cytarabine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1111/jsap.12622


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[PMID]:28161037
[Au] Autor:Pusterla N; Tobin T
[Ad] Endereço:Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA. Electronic address: npusterla@ucdavis.edu.
[Ti] Título:Therapeutics for Equine Protozoal Myeloencephalitis.
[So] Source:Vet Clin North Am Equine Pract;33(1):87-97, 2017 Apr.
[Is] ISSN:1558-4224
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Equine protozoal myeloencephalitis is an infectious disease of the central nervous system caused by Sarcocystis neurona or Neospora hughesi. Affected horses routinely present with progressive and asymmetrical neurologic deficits. The diagnosis relies on the presence of neurologic signs, ruling out other neurologic disorders, and the detection of intrathecally derived antibodies to either S neurona and/or N hughesi. Recommended treatment is use of an FDA-approved anticoccidial drug formulation. Medical and supportive treatment is provided based on the severity of neurologic deficits and complications. This article focuses on recent data related to diagnosis, pharmacologic treatment, and prevention.
[Mh] Termos MeSH primário: Antiprotozoários/uso terapêutico
Encefalomielite/veterinária
Doenças dos Cavalos/tratamento farmacológico
Doenças dos Cavalos/parasitologia
Sarcocistose/veterinária
[Mh] Termos MeSH secundário: Animais
Encefalomielite/tratamento farmacológico
Encefalomielite/parasitologia
Cavalos
Neospora/isolamento & purificação
Sarcocystis/isolamento & purificação
Sarcocistose/tratamento farmacológico
Sarcocistose/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiprotozoal Agents)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE



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