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[PMID]: 29408878 [Au] Autor: Freundt-Revilla J; Heinrich F; Zoerner A; Gesell F; Beyerbach M; Shamir M; Oevermann A; Baumgärtner W; Tipold A [Ad] Endereço: Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany. [Ti] Título: The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis. [So] Source: PLoS One;13(2):e0187197, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Endocannabinoids (ECs) are involved in immunomodulation, neuroprotection and control of inflammation in the central nervous system (CNS). Activation of cannabinoid type 2 receptors (CB2) is known to diminish the release of pro-inflammatory factors and enhance the secretion of anti-inflammatory cytokines. Furthermore, the endocannabinoid 2-arachidonoyl glycerol (2-AG) has been proved to induce the migration of eosinophils in a CB2 receptor-dependent manner in peripheral blood and activate neutrophils independent of CB activation in humans. The aim of the current study was to investigate the influence of the endocannabinoid system in two different CNS inflammatory diseases of the dog, i.e. Steroid-Responsive Meningitis-Arteritis (SRMA) and Intraspinal Spirocercosis (IS). The two main endocannabinoids, anandamide (AEA) and 2-AG, were quantified by mass spectrometry in CSF and serum samples of dogs affected with Steroid- Responsive Meningitis-Arteritis in the acute phase (SRMA A), SRMA under treatment with prednisolone (SRMA Tr), intraspinal Spirocercosis and healthy dogs. Moreover, expression of the CB2 receptor was evaluated in inflammatory lesions of SRMA and IS and compared to healthy controls using immunohistochemistry (IHC). Dogs with SRMA A showed significantly higher concentrations of total AG and AEA in serum in comparison to healthy controls and in CSF compared to SRMA Tr (p<0.05). Furthermore, dogs with IS displayed the highest ECs concentrations in CSF, being significantly higher than in CSF samples of dogs with SRMA A (p<0.05). CSF samples that demonstrated an eosinophilic pleocytosis had the highest levels of ECs, exceeding those with neutrophilic pleocytosis, suggesting that ECs have a major effect on migration of eosinophils in the CSF. Furthermore, CB2 receptor expression was found in glial cells in the spinal cord of healthy dogs, whereas in dogs with SRMA and IS, CB2 was strongly expressed not only in glial cells but also on the cellular surface of infiltrating leukocytes (i.e. neutrophils, eosinophils, lymphocytes, plasma cells, and macrophages) at lesion sites. The present study revealed an upregulated endocannabinoid system in dogs with inflammatory CNS diseases, highlighting the endocannabinoid system as a potential target for treatment of inflammatory CNS diseases. [Mh] Termos MeSH primário: Arterite/veterinária Doenças do Cão/fisiopatologia Endocanabinoides/fisiologia Meningite/veterinária Doenças da Coluna Vertebral/veterinária Infecções por Spirurida/veterinária [Mh] Termos MeSH secundário: Animais Arterite/sangue Arterite/líquido cefalorraquidiano Arterite/fisiopatologia Cromatografia Líquida Doenças do Cão/sangue Doenças do Cão/líquido cefalorraquidiano Cães Endocanabinoides/sangue Endocanabinoides/líquido cefalorraquidiano Espectrometria de Massas Meningite/sangue Meningite/líquido cefalorraquidiano Meningite/fisiopatologia Doenças da Coluna Vertebral/sangue Doenças da Coluna Vertebral/líquido cefalorraquidiano Doenças da Coluna Vertebral/fisiopatologia Infecções por Spirurida/sangue Infecções por Spirurida/líquido cefalorraquidiano Infecções por Spirurida/fisiopatologia Espectrometria de Massas em Tandem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Endocannabinoids) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180207 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0187197

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[PMID]: 28468135 [Au] Autor: Burakgazi G; Bayarogullari H; Öztürk F; Arli C; Motor VK; Yanmaz R; Atci N [Ad] Endereço: *Department of Radiology †Department of Ear, Nose, and Throat ‡Department of Infectious Diseases, Mustafa Kemal University Medical School, Hatay §Department of Radiology, Gaziantep Special Love Hospital, Gaziantep, Turkey. [Ti] Título: Radiological Imaging of Rare Intracranial Complications Secondary to Otitis Media and Mastoiditis. [So] Source: J Craniofac Surg;28(3):620-624, 2017 May. [Is] ISSN: 1536-3732 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Acute otitis media used to cause fatal results because of its intracranial complications before the introduction of potent and effective antibiotics. After the introduction of antibiotics, complications have started to be observed more frequently as a result of chronic otitis media and especially in children. Because clinical findings changed and became indistinct, the diagnosis of otitis and mastoiditis has been made occasionally with imaging findings only after complications occurred. Multidetector computed tomography and magnetic resonance imaging are efficient and sufficient methods in the rapid diagnosis and should be immediately referred methods. [Mh] Termos MeSH primário: Abscesso Encefálico/diagnóstico por imagem Imagem por Ressonância Magnética Mastoidite/complicações Meningite/diagnóstico por imagem Tomografia Computadorizada Multidetectores Otite Média/complicações Tromboflebite/diagnóstico por imagem [Mh] Termos MeSH secundário: Doença Aguda Adolescente Adulto Idoso Abscesso Encefálico/etiologia Criança Doença Crônica Feminino Seres Humanos Masculino Mastoidite/diagnóstico por imagem Meningite/etiologia Meia-Idade Otite Média/diagnóstico por imagem Estudos Retrospectivos Tromboflebite/etiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180202 [Lr] Data última revisão: 180202 [Sb] Subgrupo de revista: D [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1097/SCS.0000000000003391

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[PMID]: 29229308 [Au] Autor: Mangus LM; Beck SE; Queen SE; Brill SA; Shirk EN; Metcalf Pate KA; Muth DC; Adams RJ; Gama L; Clements JE; Mankowski JL [Ad] Endereço: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland. [Ti] Título: Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus-Infected Macaques Receiving Antiretroviral Therapy. [So] Source: Am J Pathol;188(1):125-134, 2018 01. [Is] ISSN: 1525-2191 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A retrospective neuropathologic review of 30 SIV-infected pigtailed macaques receiving combination antiretroviral therapy (cART) was conducted. Seventeen animals with lymphocyte-dominant inflammation in the brain and/or meninges that clearly was morphologically distinct from prototypic SIV encephalitis and human immunodeficiency virus encephalitis were identified. Central nervous system (CNS) infiltrates in cART-treated macaques primarily comprised CD20 B cells and CD3 T cells with fewer CD68 macrophages. Inflammation was associated with low levels of SIV RNA in the brain as shown by in situ hybridization, and generally was observed in animals with episodes of cerebrospinal fluid (CSF) viral rebound or sustained plasma and CSF viremia during treatment. Although the lymphocytic CNS inflammation in these macaques shared morphologic characteristics with uncommon immune-mediated neurologic disorders reported in treated HIV patients, including CNS immune reconstitution inflammatory syndrome and neurosymptomatic CSF escape, the high prevalence of CNS lesions in macaques suggests that persistent adaptive immune responses in the CNS also may develop in neuroasymptomatic or mildly impaired HIV patients yet remain unrecognized given the lack of access to CNS tissue for histopathologic evaluation. Continued investigation into the mechanisms and outcomes of CNS inflammation in cART-treated, SIV-infected macaques will advance our understanding of the consequences of residual CNS HIV replication in patients on cART, including the possible contribution of adaptive immune responses to HIV-associated neurocognitive disorders. [Mh] Termos MeSH primário: Antirretrovirais/uso terapêutico Encéfalo/patologia Encefalite/patologia Linfócitos/patologia Meningite/patologia Síndrome de Imunodeficiência Adquirida dos Símios/patologia [Mh] Termos MeSH secundário: Animais Encefalite/complicações Inflamação/patologia Macaca nemestrina Masculino Meningite/complicações Síndrome de Imunodeficiência Adquirida dos Símios/complicações Síndrome de Imunodeficiência Adquirida dos Símios/tratamento farmacológico Vírus da Imunodeficiência Símia Carga Viral [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL [Nm] Nome de substância: 0 (Anti-Retroviral Agents) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180131 [Lr] Data última revisão: 180131 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE

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[PMID]: 29240825 [Au] Autor: Santiago-Tirado FH; Doering TL [Ad] Endereço: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America. [Ti] Título: False friends: Phagocytes as Trojan horses in microbial brain infections. [So] Source: PLoS Pathog;13(12):e1006680, 2017 12. [Is] ISSN: 1553-7374 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Meningite/imunologia Meningite/microbiologia Fagócitos/imunologia Fagócitos/microbiologia [Mh] Termos MeSH secundário: Encéfalo/imunologia Encéfalo/microbiologia Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180102 [Lr] Data última revisão: 180102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171215 [St] Status: MEDLINE [do] DOI: 10.1371/journal.ppat.1006680

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[PMID]: 28949969 [Au] Autor: Al-Janabi H; Manca A; Coast J [Ad] Endereço: Health Economics Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom. [Ti] Título: Predicting carer health effects for use in economic evaluation. [So] Source: PLoS One;12(9):e0184886, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Illnesses and interventions can affect the health status of family carers in addition to patients. However economic evaluation studies rarely incorporate data on health status of carers. OBJECTIVES: We investigated whether changes in carer health status could be 'predicted' from the health data of those they provide care to (patients), as a means of incorporating carer outcomes in economic evaluation. METHODS: We used a case study of the family impact of meningitis, with 497 carer-patient dyads surveyed at two points. We used regression models to analyse changes in carers' health status, to derive predictive algorithms based on variables relating to the patient. We evaluated the predictive accuracy of different models using standard model fit criteria. RESULTS: It was feasible to estimate models to predict changes in carers' health status. However, the predictions generated in an external testing sample were poorly correlated with the observed changes in individual carers' health status. When aggregated, predictions provided some indication of the observed health changes for groups of carers. CONCLUSIONS: At present, a 'one-size-fits-all' predictive model of carer outcomes does not appear possible and further research aimed to identify predictors of carer's health status from (readily available) patient data is recommended. In the meanwhile, it may be better to encourage the targeted collection of carer data in primary research to enable carer outcomes to be better reflected in economic evaluation. [Mh] Termos MeSH primário: Cuidadores Economia [Mh] Termos MeSH secundário: Família Nível de Saúde Seres Humanos Meningite/enfermagem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170927 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0184886

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[PMID]: 28885354 [Au] Autor: Sulaiman T; Salazar L; Hasbun R [Ad] Endereço: Department of Internal Medicine, Section of Infectious Diseases, UT Health McGovern Medical School, TX, USA. [Ti] Título: Acute versus subacute community-acquired meningitis: Analysis of 611 patients. [So] Source: Medicine (Baltimore);96(36):e7984, 2017 Sep. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Community-acquired meningitis can be classified into acute and subacute presentations by the duration of illness of ≤ or >5 days, respectively. There are currently no studies comparing the clinical features, management decisions, etiologies, and outcomes between acute and subacute presentations.It is a retrospective study of adults with community-acquired meningitis hospitalized in Houston, TX between January 2005 and January 2010. An adverse clinical outcome was defined as a Glasgow Outcome Scale score of ≤4.A total of 611 patients were identified, of which 458 (75%) were acute and 153 subacute (25%). The most common etiologies were unknown in 418 (68.4%), viral in 94 (15.4%), bacterial in 47 (7.7%), fungal in 42 patients (6.9%), and other noninfectious etiologies in 6 (1%). Patients with subacute meningitis were more likely to be immunosuppressed or have comorbidities, had fungal etiologies, and had higher rates of hypoglycorrachia and abnormal neurological findings (P <.05). Patients with an acute presentation were more likely to be treated empirically with intravenous antibiotics and had higher cerebrospinal fluid pleocytosis and serum white blood cell counts (P <.05). On logistic regression, age >65 years and abnormal neurological findings were predictive of an adverse clinical outcome in both acute and subacute meningitis, whereas fever was also a significant prognostic factor in acute meningitis. (P <.05).Acute and subacute meningitis differ in regards to clinical presentations, etiologies, laboratory findings, and management decisions, but did not differ in rates of adverse clinical outcomes. Future studies including thoroughly investigated patients with new diagnostic molecular methods may show different results and outcomes. [Mh] Termos MeSH primário: Meningite/fisiopatologia Meningite/terapia [Mh] Termos MeSH secundário: Doença Aguda Adolescente Adulto Idoso Idoso de 80 Anos ou mais Infecções Comunitárias Adquiridas/epidemiologia Infecções Comunitárias Adquiridas/etiologia Infecções Comunitárias Adquiridas/fisiopatologia Infecções Comunitárias Adquiridas/terapia Feminino Escala de Resultado de Glasgow Seres Humanos Modelos Logísticos Masculino Meningite/epidemiologia Meningite/etiologia Meia-Idade Estudos Retrospectivos Texas Fatores de Tempo Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170918 [Lr] Data última revisão: 170918 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170909 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000007984

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[PMID]: 28802374 [Au] Autor: Verma RK; Kaur N [Ad] Endereço: Department of Otolaryngology, Head and Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address: roshanverma@hotmail.com. [Ti] Título: Secondary encephalocele in infant following subdural empyema repaired endoscopically-A case report. [So] Source: Int J Pediatr Otorhinolaryngol;100:211-215, 2017 Sep. [Is] ISSN: 1872-8464 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: Subdural empyema (SDE) is an uncommon entity, mostly associated with meningitis and can be life threatening in infants. Rarely, a subdural empyema can lead to nasal encephalocele which can be challenging situation to manage especially in infant. We present a case of 7 month old infant who presented with subdural empyema that led to formation of nasal encaphalocele after 4 months which was managed endoscopic route. [Mh] Termos MeSH primário: Empiema Subdural/complicações Encefalocele/etiologia Meningite/complicações [Mh] Termos MeSH secundário: Encefalocele/cirurgia Endoscopia Seres Humanos Lactente Masculino [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170907 [Lr] Data última revisão: 170907 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170814 [St] Status: MEDLINE

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[PMID]: 28791846 [Au] Autor: Kepka A; Janas RM; Pancewicz SA; Swierzbinska R [Ad] Endereço: Department of Biochemistry, Radioimmunology and Experimental Medicine, the Children's Memorial Health Institute, Warszawa, Poland. [Ti] Título: Serum carnitine and acyl-carnitine in patients with meningitis due to tick-borne encephalitis virus infection. [So] Source: Adv Clin Exp Med;26(2):277-280, 2017 Mar-Apr. [Is] ISSN: 1899-5276 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: BACKGROUND: Hard ticks are the main vectors of tick-borne encephalitis virus (TBEV). Free carnitine (FC) and acylcarnitines (AC) have the basic role in ß-oxidation as well as the modulation of immune and nervous system. Homeostasis of carnitines in the TBE patients was not studied so far. OBJECTIVES: This study aimed to evaluate FC and AC serum concentrations in patients with meningitis due to TBEV infection before and after 14 ± 3 days of treatment. MATERIAL AND METHODS: The study was performed in 14 patients aged 48 ± 29 years that were divided a posteriori (based on their FC level before and after treatment) into 2 subgroups: 1-8 and 9-14. Diagnosis was based on the neurological, serological and pleocytosis evaluation. RESULTS: The FC level in patients 1-8 before treatment (24.1 ± 8.1) was significantly lower than in patients post-treatment (34.4 ± 8.3), lower than in the control group (40.5 ± 7.6), and lower than in patients 9-14 before treatment (40.0 ± 13.5) but not lower than in the patients 9-14 after treatment (24.7 ± 7.3 µmol/L), respectively, p < 0.05. AC concentration in the patients 1-8 before treatment (4.7 ± 2.2) was apparently lower than in patients post-treatment (9.5 ± 3.9 µmol/L) but the values were not significantly different. In patients 9-14 before treatment the AC concentration (16.3 ± 12.6) was higher than in patients after treatment (5.3 ± 4.0 µmol/L), but the difference was not statistically significant. CONCLUSIONS: FC and AC homeostasis in circulation was disturbed in the patients with meningitis due to TBEV infection patients. The mean levels of FC and AC in 60% of the patients were below the normal range but normalized after treatment whereas in 40% of the patients they were near or at a normal range and significantly decreased after treatment. Explanation of this intriguing finding and its clinical significance is not easy without further studies. [Mh] Termos MeSH primário: Carnitina/análogos & derivados Carnitina/sangue Vírus da Encefalite Transmitidos por Carrapatos/isolamento & purificação Encefalite Transmitida por Carrapatos/sangue Meningite/sangue [Mh] Termos MeSH secundário: Adulto Idoso Animais Anticorpos Antivirais/sangue Anticorpos Antivirais/imunologia Vírus da Encefalite Transmitidos por Carrapatos/imunologia Vírus da Encefalite Transmitidos por Carrapatos/fisiologia Encefalite Transmitida por Carrapatos/complicações Encefalite Transmitida por Carrapatos/virologia Feminino Seres Humanos Imunoglobulina G/sangue Imunoglobulina G/imunologia Imunoglobulina M/sangue Imunoglobulina M/imunologia Masculino Meningite/complicações Meningite/terapia Meia-Idade Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Antibodies, Viral); 0 (Immunoglobulin G); 0 (Immunoglobulin M); 0 (acylcarnitine); S7UI8SM58A (Carnitine) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170908 [Lr] Data última revisão: 170908 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170810 [St] Status: MEDLINE [do] DOI: 10.17219/acem/63006

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[PMID]: 28723776 [Au] Autor: Huang Y; Chen J; Gui L [Ad] Endereço: aDepartment of Neurology bDepartment of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery, Southwest Hospital, The Third Military Medical University, Chongqing, China. [Ti] Título: A case of idiopathic hypertrophic pachymeningitis presenting with chronic headache and multiple cranial nerve palsies: A case report. [So] Source: Medicine (Baltimore);96(29):e7549, 2017 Jul. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Idiopathic hypertrophic pachymeningitis (IHP) is a rare condition, characterized by a chronic fibrosing inflammatory process usually involving either the intracranial or spinal dura mater, but rarely both. Here, we report a rare case of IHP affecting both the intracranial and spinal dura mater. We also discussed the diagnosis, management, and outcome of IHP. PATIENT CONCERNS: We reviewed the case of a 60-year-old woman presenting with chronic headache, multiple cranial nerve palsies and gait disturbance. Magnetic resonance imaging (MRI) of her head revealed thickened and contrast-enhanced dura in the craniocervical region as well as obstructive hydrocephalus and cerebellar tonsillar herniation. The patient had a suboccipital craniectomy and posterior decompression through C1 plus a total laminectomy. The dura was partially resected to the extent of the bony decompression, and a duroplasty was performed. DIAGNOSES: Microscopic examination of the surgically resected sample showed chronic inflammatory changes, lymphoplasmacytic cell infiltration, fibrous tissue hyperplasia, and hyaline degeneration. Blood tests to evaluate the secondary causes of hypertrophic pachymeningitis (HP) were unremarkable. INTERVENTIONS: Steroid was used to treat suspected IHP. OUTCOMES: Postoperatively, the patient showed gradual improvement in her headache, glossolalia, and bucking. Prior to discharge, a follow-up MRI showed improvement of the dura mater thickening. LESSONS: IHP is a chronic inflammatory disorder of the dura mater that usually causes neurological deficits. Clinical manifestations of IHP, MRI findings, and laboratory abnormalities are the essential components for making an accurate diagnosis. When the radiological or laboratory evaluation is uncertain, but neurological deficits are present, a prompt surgical approach should be considered. Postoperative steroid therapy and close observation for recurrence are necessary to ensure a good long-term outcome. [Mh] Termos MeSH primário: Doenças dos Nervos Cranianos/complicações Doenças dos Nervos Cranianos/diagnóstico Transtornos da Cefaleia/complicações Transtornos da Cefaleia/diagnóstico Meningite/complicações Meningite/diagnóstico [Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem Doenças dos Nervos Cranianos/patologia Doenças dos Nervos Cranianos/terapia Diagnóstico Diferencial Dura-Máter/diagnóstico por imagem Dura-Máter/patologia Dura-Máter/cirurgia Feminino Transtornos da Cefaleia/patologia Transtornos da Cefaleia/terapia Seres Humanos Meningite/patologia Meningite/terapia Meia-Idade [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170808 [Lr] Data última revisão: 170808 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170721 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000007549

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[PMID]: 28683957 [Au] Autor: Ballivet de Régloix S; Maurin O; Crambert A; Genestier L; Bonfort G; Pons Y [Ad] Endereço: Hôpital d'instruction des Armées-Percy, service d'ORL et de chirurgie cervico-faciale, 101, avenue Henri-Barbusse, 92140 Clamart, France. Electronic address: stanbdr@msn.com. [Ti] Título: [Complications of sinusitis]. [Ti] Título: Complications des sinusites.. [So] Source: Presse Med;46(7-8 Pt 1):655-659, 2017 Jul - Aug. [Is] ISSN: 2213-0276 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: The complications of sinusitis are essentially secondary to ethmoidal and frontal sinusitis, occurring in patients weakened, particularly in case of immunodeficiency or anatomical defects. The gravity is due to the risk of spreading infection in intracranial tissues and orbital cavity. The diagnosis is always to discuss any symptomatology resistant to treatment and the appearance of orbital or neurological signs. The scanner and MRI contribute greatly to the orientation and diagnostic evaluation of the extent of the lesions. Treatment is based on prolonged antibiotic therapy and surgery and requires a multidisciplinary approach involving ENT, ophthalmologist, neurosurgeon and anesthesiologist resuscitator. [Mh] Termos MeSH primário: Sinusite/complicações [Mh] Termos MeSH secundário: Abscesso Encefálico/etiologia Empiema/etiologia Seres Humanos Meningite/etiologia Mucocele/etiologia Celulite Orbitária/etiologia Osteomielite/etiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170911 [Lr] Data última revisão: 170911 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170708 [St] Status: MEDLINE

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