Base de dados : MEDLINE
Pesquisa : C10.228.662 [Categoria DeCS]
Referências encontradas : 13597 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1360 ir para página                         

  1 / 13597 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28469563
[Au] Autor:Kerr MSD; Sacré P; Kahn K; Park HJ; Johnson M; Lee J; Thompson S; Bulacio J; Jones J; González-Martínez J; Liégeois-Chauvel C; Sarma SV; Gale JT
[Ad] Endereço:Department of Biomedical Engineering, Johns Hopkins UniversityBaltimore, MD, USA.
[Ti] Título:The Role of Associative Cortices and Hippocampus during Movement Perturbations.
[So] Source:Front Neural Circuits;11:26, 2017.
[Is] ISSN:1662-5110
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Although motor control has been extensively studied, most research involving neural recordings has focused on primary motor cortex, pre-motor cortex, supplementary motor area, and cerebellum. These regions are involved during normal movements, however, associative cortices and hippocampus are also likely involved during perturbed movements as one must detect the unexpected disturbance, inhibit the previous motor plan, and create a new plan to compensate. Minimal data is available on these brain regions during such "robust" movements. Here, epileptic patients implanted with intracerebral electrodes performed reaching movements while experiencing occasional unexpected force perturbations allowing study of the fronto-parietal, limbic and hippocampal network at unprecedented high spatial, and temporal scales. Areas including orbitofrontal cortex (OFC) and hippocampus showed increased activation during perturbed trials. These results, coupled with a visual novelty control task, suggest the hippocampal MTL-P300 novelty response is modality independent, and that the OFC is involved in modifying motor plans during robust movement.
[Mh] Termos MeSH primário: Mapeamento Encefálico
Córtex Cerebral/fisiopatologia
Potenciais Evocados Visuais/fisiologia
Hipocampo/fisiopatologia
Transtornos dos Movimentos/patologia
[Mh] Termos MeSH secundário: Adulto
Eletroencefalografia
Epilepsia/complicações
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Transtornos dos Movimentos/etiologia
Vias Neurais/fisiopatologia
Testes Neuropsicológicos
Estimulação Luminosa
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.3389/fncir.2017.00026


  2 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28468925
[Au] Autor:Wang YL; Lin GH; Huang YJ; Chen MH; Hsieh CL
[Ad] Endereço:From the Department of Rehabilitation, Chi Mei Medical Center, Tainan, Taiwan (Y.-L.W.); Center of General Education, Southern Taiwan University of Science and Technology, Tainan (Y.-L.W.); School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei (G.-H.L., Y.-J.H., C.-
[Ti] Título:Refining 3 Measures to Construct an Efficient Functional Assessment of Stroke.
[So] Source:Stroke;48(6):1630-1635, 2017 06.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The Fugl-Meyer Assessment motor scale, Postural Assessment Scale for Stroke patients, and Barthel Index are widely used to assess patients' upper extremity and lower extremity motor function, balance, and basic activities of daily living after stroke, respectively. However, these 3 measures (72 items) require a great amount of time for assessment. Therefore, we aimed to develop an efficient test, the Functional Assessment of Stroke (FAS). METHODS: The FAS was constructed from 4 short-form tests of the Fugl-Meyer Assessment-upper extremity, Fugl-Meyer Assessment-lower extremity, Postural Assessment Scale for Stroke patients, and Barthel Index based on the results of Rasch analyses and the items' content. We examined the psychometric properties of the FAS, including Rasch reliability, concurrent validity, convergent validity, known-group validity, and responsiveness. RESULTS: The FAS contained 29 items (10, 6, 8, and 5 items for the 4 short-form tests, respectively). The FAS demonstrated high Rasch reliability (0.92-0.94), concurrent validity ( =0.90-0.97 with the original tests), convergent validity ( =0.62-0.94 with the 5-scale Fugl-Meyer Assessment), and known-group validity (significant difference in the FAS scores among 3 groups of disability levels; <0.001). In addition, the responsiveness of the FAS (standardized response mean=0.55-1.93) was similar or significantly superior to those of the original tests (standardized response mean=0.46-1.39). CONCLUSIONS: The FAS contains 29 items and has sufficient Rasch reliability, validities, and responsiveness. These findings support that the FAS is efficient for reliably and validly assessing upper extremity/lower extremity motor function, balance, and basic activities of daily living and for sensitively detecting change in those functions in patients with stroke.
[Mh] Termos MeSH primário: Atividades Cotidianas
Extremidade Inferior/fisiopatologia
Transtornos dos Movimentos/diagnóstico
Equilíbrio Postural/fisiologia
Índice de Gravidade de Doença
Acidente Vascular Cerebral/diagnóstico
Extremidade Superior/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos dos Movimentos/etiologia
Psicometria/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.116.015516


  3 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29220673
[Au] Autor:Martin S; Chamberlin A; Shinde DN; Hempel M; Strom TM; Schreiber A; Johannsen J; Ousager LB; Larsen MJ; Hansen LK; Fatemi A; Cohen JS; Lemke J; Sørensen KP; Helbig KL; Lessel D; Abou Jamra R
[Ad] Endereço:Institute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.
[Ti] Título:De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.
[So] Source:Am J Hum Genet;101(6):1013-1020, 2017 Dec 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using trio whole-exome sequencing, we have identified de novo heterozygous pathogenic variants in GRIA4 in five unrelated individuals with intellectual disability and other symptoms. GRIA4 encodes an AMPA receptor subunit known as GluR4, which is found on excitatory glutamatergic synapses and is important for learning and memory. Four of the variants are located in the highly conserved SYTANLAAF motif in the transmembrane protein M3, and the fifth is in an extra-cellular domain. Molecular modeling of the altered protein showed that three of the variants in the SYTANLAAF motif orient toward the center of the pore region and most likely lead to disturbance of the gating mechanism. The fourth variant in the SYTANLAAF motif most likely results in reduced permeability. The variant in the extracellular domain potentially interferes with the binding between the monomers. On the basis of clinical information and genetic results, and the fact that other subunits of the AMPA receptor have already been associated with neurodevelopmental disorders, we suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features.
[Mh] Termos MeSH primário: Transtornos Neurológicos da Marcha/genética
Deficiência Intelectual/genética
Transtornos dos Movimentos/genética
Receptores de AMPA/genética
Convulsões/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Pré-Escolar
Feminino
Seres Humanos
Masculino
Modelos Moleculares
Comportamento Problema
Comportamento Social
Sequenciamento Completo do Exoma
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, AMPA); 0 (glutamate receptor ionotropic, AMPA 4)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  4 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29211113
[Au] Autor:Felício CM; Lima MDRF; Medeiros APM; Ferreira JTL
[Ad] Endereço:Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - USP - Ribeirão Preto (SP), Brazil.
[Ti] Título:Orofacial Myofunctional Evaluation Protocol for older people: validity, psychometric properties, and association with oral health and age.
[So] Source:Codas;29(6):e20170042, 2017 Dec 04.
[Is] ISSN:2317-1782
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To develop a comprehensive assessment protocol for identifying, classifying and grading changes in stomatognathic system components and functions of older people, to determine its psychometric properties and verify its association with oral health and age. METHODS: The content validity of the Orofacial Myofunctional Evaluation with Scores for Elders protocol (OMES-Elders) was established based on the literature. The protocol contains three domains: appearance/posture, mobility, and functions of the stomatognathic system. Eighty-two healthy elder volunteers (mean age 69±7.24 years) were evaluated using the OMES-Elders. A test-screening for orofacial disorders (reference) was used to analyze the concurrent validity (correlation test), sensitivity, specificity and accuracy (Receiver Operating Characteristic Curve: ROC curve) of the OMES-Elders. The association of the OMES-Elders scores with the Oral Health Index (OHX) and age in the sample was tested. RESULTS: There was a significant correlation between the OMES-Elders and the reference test (p < 0.001). Reliability coefficients ranged from good (0.89) to excellent (0.99). The OMES-Elders protocol had a sensitivity of 82.9%, specificity of 83.3% and accuracy of 0.83. The scores of the protocol were significantly lower in individuals with worse oral health (OHX ≤ 61%), although individuals with adequate oral health (OHX ≥ 90%) also had myofunctional impairments. The predictors OHX and age explained, respectively, 33% and 30% of the variance in the OMES-Elders total score. CONCLUSION: As the first specific orofacial myofunctional evaluation of older people, the OMES-Elders protocol proved to be valid, reliable and its total score was associated with oral health and age.
[Mh] Termos MeSH primário: Protocolos Clínicos
Transtornos de Deglutição/diagnóstico
Transtornos dos Movimentos/diagnóstico
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Músculos Faciais/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Terapia Miofuncional
Saúde Bucal
Psicometria
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  5 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460362
[Au] Autor:Oustwani CS; Korutz AW; Lester MS; Kianirad Y; Simuni T; Hijaz TA
[Ad] Endereço:Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
[Ti] Título:Can loss of the swallow tail sign help distinguish between Parkinson Disease and the Parkinson-Plus syndromes?
[So] Source:Clin Imaging;44:66-69, 2017 Jul - Aug.
[Is] ISSN:1873-4499
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine if loss of the swallow tail sign (STS) can distinguish Parkinson Disease (PD) from the Parkinson-Plus syndromes. METHODS: Twenty-five patients with PD, 21 with Parkinson-Plus syndromes, and 14 control patients were included. Presence of the STS was assessed. RESULTS: The STS was present in 79% of controls, statistically greater than the PD/Parkinson-Plus patients. There was no difference in the presence of the STS between the PD/Parkinson-Plus subgroups or when scanning at 1.5 T or 3 T. CONCLUSIONS: Loss of the STS could not distinguish between PD and Parkinson-Plus patients. The STS can be identified at both 1.5 T and 3 T.
[Mh] Termos MeSH primário: Transtornos dos Movimentos/diagnóstico
Doença de Parkinson/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Diferencial
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Transtornos dos Movimentos/diagnóstico por imagem
Doença de Parkinson/diagnóstico por imagem
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  6 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27773422
[Au] Autor:Sadighi ZS; Zabrowski J; Boop FA; Broniscer A; Gajjar A; Khan RB
[Ad] Endereço:Division of Neurology, Department of Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee. Electronic address: zsila.sadighi@stjude.org.
[Ti] Título:Clinical Characteristics and Long-Term Outcomes of Movement Disorders in Childhood Thalamic Tumors.
[So] Source:Pediatr Neurol;65:71-77, 2016 Dec.
[Is] ISSN:1873-5150
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We studied the outcomes of movement disorders that were associated with childhood thalamic tumors. METHODS: We retrospectively reviewed 83 children with thalamic tumors treated at our institution from 1996 to 2013 to document the incidence and outcome of movement disorders. Magnetic resonance imaging was used to analyze the involvement of thalamic nuclei, and three instruments were used to rate the severity of the disorders. RESULTS: Nine (11%) patients had one or more of the following movement disorders: postural tremor, resting tremor, ballism, dystonia, myoclonus, and athetosis. Median age at tumor diagnosis was seven years (range, 0.25 to 11 years), and the average age at movement disorder onset was eight years (range, 1.5 to 11 years). Movement disorders developed at a median of 1.5 months (range, 0 to 4 months) after surgical resection. The severity of the disorders was either unchanged or slightly improved during follow-up. The red nuclei were the only thalamic structures that showed tumor involvement in all nine patients. CONCLUSIONS: No specific injury of the thalamic nuclei was associated with movement disorders in children with thalamic tumors, and the severity of these disorders did not change over time.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/cirurgia
Transtornos dos Movimentos/diagnóstico por imagem
Transtornos dos Movimentos/cirurgia
Tálamo/diagnóstico por imagem
Tálamo/cirurgia
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/complicações
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Transtornos dos Movimentos/etiologia
Estudos Retrospectivos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  7 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27779314
[Au] Autor:Jacquier D; Newman CJ
[Ad] Endereço:Paediatric Neurology and Neurorehabilitation Unit, Department of Paediatrics, University Hospital of Lausanne, Lausanne, Switzerland.
[Ti] Título:Co-sleeping in school-aged children with a motor disability: a comparative population-based study.
[So] Source:Dev Med Child Neurol;59(4):420-426, 2017 04.
[Is] ISSN:1469-8749
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To determine the prevalence and determinants of co-sleeping in school-aged children with a motor disability compared with the school-aged general population. METHOD: A questionnaire on demographic characteristics and co-sleeping habits, along with the Sleep Disturbance Scale for Children (SDSC), was sent to parents of children aged between 4 years and 18 years followed in our tertiary paediatric neurorehabilitation clinic, and to school-aged children in a representative sample of state schools. RESULT: We analysed responses for 245 children with motor disability (142 males, 103 females; mean age 10y 6mo, standard deviation [SD] 3y 10mo, range 4-18y) and 2891 of the general population (1484 males, 1497 females; mean age [SD] 9y 6mo [3y 5mo], range 4-18y) (response rates 37% and 26% respectively). Cerebral palsy was the most common diagnosis among children with motor disability. Weekly co-sleeping was significantly more common in children with motor disability than in the general population (11.8% vs 7.9% respectively, p=0.032). Special care of the child with motor disability at night, mainly addressing epilepsy, was reported as a cause of co-sleeping by two-thirds of parents. Factors associated with co-sleeping in the motor disability group were age, housing crowding, severe visual impairment, and pathological sleep according to the SDSC. INTERPRETATION: Co-sleeping is common among children with motor disability. It is influenced by personal and medical factors, as well as the requirements for special care at night. Therefore, health professionals should explore sleeping arrangements in families of children with motor disability.
[Mh] Termos MeSH primário: Dissonias/epidemiologia
Hábitos
Transtornos dos Movimentos/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Criança
Pré-Escolar
Planejamento em Saúde Comunitária
Estudos Transversais
Dissonias/psicologia
Feminino
Seres Humanos
Masculino
Pais/psicologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171209
[Lr] Data última revisão:
171209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/dmcn.13300


  8 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27773446
[Au] Autor:Finsterer J; Zarrouk-Mahjoub S
[Ad] Endereço:Krankenanstalt Rudolfstiftung, Vienna, Austria. Electronic address: fipaps@yahoo.de.
[Ti] Título:Mitochondrial movement disorders.
[So] Source:Rev Neurol (Paris);172(11):716-717, 2016 11.
[Is] ISSN:0035-3787
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Mitocôndrias
Doenças Mitocondriais
[Mh] Termos MeSH secundário: Seres Humanos
Movimento
Transtornos dos Movimentos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  9 / 13597 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28466625
[Au] Autor:Gross I; Gross-Tsur V
[Ad] Endereço:Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.
[Ti] Título:Paroxysmal Tonic Upward Gaze at Adolescence: A Girl with Prader-Willi Syndrome.
[So] Source:Isr Med Assoc J;18(11):703-704, 2016 Nov.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Mh] Termos MeSH primário: Ataxia/diagnóstico
Transtornos dos Movimentos/diagnóstico
Transtornos da Motilidade Ocular/diagnóstico
Síndrome de Prader-Willi/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Ataxia/fisiopatologia
Feminino
Seres Humanos
Transtornos dos Movimentos/fisiopatologia
Transtornos da Motilidade Ocular/fisiopatologia
Síndrome de Prader-Willi/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  10 / 13597 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29069568
[Au] Autor:Dwivedi R; Ramanujam B; Chandra PS; Sapra S; Gulati S; Kalaivani M; Garg A; Bal CS; Tripathi M; Dwivedi SN; Sagar R; Sarkar C; Tripathi M
[Ad] Endereço:From the Departments of Neurology (R.D., B.R., Manjari Tripathi), Neurosurgery (P.S.C.), Pediatrics (S.S., S.G.), Biostatistics (M.K., S.N.D.), Neuro-Radiology (A.G.), Nuclear Medicine (C.S.B., Madhavi Tripathi), Psychiatry (R.S.), and Pathology (C.S.), All India Institute of Medical Sciences, New D
[Ti] Título:Surgery for Drug-Resistant Epilepsy in Children.
[So] Source:N Engl J Med;377(17):1639-1647, 2017 10 26.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials. METHODS: In this single-center trial, we randomly assigned 116 patients who were 18 years of age or younger with drug-resistant epilepsy to undergo brain surgery appropriate to the underlying cause of epilepsy along with appropriate medical therapy (surgery group, 57 patients) or to receive medical therapy alone (medical-therapy group, 59 patients). The patients in the medical-therapy group were assigned to a waiting list for surgery. The primary outcome was freedom from seizures at 12 months. Secondary outcomes were the score on the Hague Seizure Severity scale, the Binet-Kamat intelligence quotient, the social quotient on the Vineland Social Maturity Scale, and scores on the Child Behavior Checklist and the Pediatric Quality of Life Inventory. RESULTS: At 12 months, freedom from seizures occurred in 44 patients (77%) in the surgery group and in 4 (7%) in the medical-therapy group (P<0.001). Between-group differences in the change from baseline to 12 months significantly favored surgery with respect to the score on the Hague Seizure Severity scale (difference, 19.4; 95% confidence interval [CI], 15.8 to 23.1; P<0.001), on the Child Behavior Checklist (difference, 13.1; 95% CI, 10.7 to 15.6; P<0.001), on the Pediatric Quality of Life Inventory (difference, 21.9; 95% CI, 16.4 to 27.6; P<0.001), and on the Vineland Social Maturity Scale (difference, 4.7; 95% CI, 0.4 to 9.1; P=0.03), but not on the Binet-Kamat intelligence quotient (difference, 2.5; 95% CI, -0.1 to 5.1; P=0.06). Serious adverse events occurred in 19 patients (33%) in the surgery group, including hemiparesis in 15 (26%). CONCLUSIONS: In this single-center trial, children and adolescents with drug-resistant epilepsy who had undergone epilepsy surgery had a significantly higher rate of freedom from seizures and better scores with respect to behavior and quality of life than did those who continued medical therapy alone at 12 months. Surgery resulted in anticipated neurologic deficits related to the region of brain resection. (Funded by the Indian Council of Medical Research and others; Clinical Trial Registry-India number, CTRI/2010/091/000525 .).
[Mh] Termos MeSH primário: Lobectomia Temporal Anterior
Anticonvulsivantes/uso terapêutico
Epilepsia/tratamento farmacológico
Epilepsia/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Lobectomia Temporal Anterior/efeitos adversos
Criança
Comportamento Infantil
Pré-Escolar
Disfunção Cognitiva/etiologia
Resistência a Medicamentos
Feminino
Seres Humanos
Lactente
Estimativa de Kaplan-Meier
Masculino
Transtornos dos Movimentos/etiologia
Paresia/etiologia
Complicações Pós-Operatórias
Qualidade de Vida
Convulsões/prevenção & controle
Inquéritos e Questionários
Lobo Temporal/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anticonvulsants)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1615335



página 1 de 1360 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde