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[PMID]:28459979
[Au] Autor:Whitman MC; Engle EC
[Ad] Endereço:F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
[Ti] Título:Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance.
[So] Source:Hum Mol Genet;26(R1):R37-R44, 2017 08 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Unraveling the genetics of the paralytic strabismus syndromes known as congenital cranial dysinnervation disorders (CCDDs) is both informing physicians and their patients and broadening our understanding of development of the ocular motor system. Genetic mutations underlying ocular CCDDs alter either motor neuron specification or motor nerve development, and highlight the importance of modulations of cell signaling, cytoskeletal transport, and microtubule dynamics for axon growth and guidance. Here we review recent advances in our understanding of two CCDDs, congenital fibrosis of the extraocular muscles (CFEOM) and Duane retraction syndrome (DRS), and discuss what they have taught us about mechanisms of axon guidance and selective vulnerability. CFEOM presents with congenital ptosis and restricted eye movements, and can be caused by heterozygous missense mutations in the kinesin motor protein KIF21A or in the ß-tubulin isotypes TUBB3 or TUBB2B. CFEOM-causing mutations in these genes alter protein function and result in axon growth and guidance defects. DRS presents with inability to abduct one or both eyes. It can be caused by decreased function of several transcription factors critical for abducens motor neuron identity, including MAFB, or by heterozygous missense mutations in CHN1, which encodes α2-chimaerin, a Rac-GAP GTPase that affects cytoskeletal dynamics. Examination of the orbital innervation in mice lacking Mafb has established that the stereotypical misinnervation of the lateral rectus by fibers of the oculomotor nerve in DRS is secondary to absence of the abducens nerve. Studies of a CHN1 mouse model have begun to elucidate mechanisms of selective vulnerability in the nervous system.
[Mh] Termos MeSH primário: Axônios/fisiologia
Síndrome da Retração Ocular/genética
Fibrose/genética
Oftalmoplegia/genética
[Mh] Termos MeSH secundário: Animais
Axônios/metabolismo
Anormalidades Congênitas
Síndrome da Retração Ocular/metabolismo
Síndrome da Retração Ocular/patologia
Oftalmopatias Hereditárias/genética
Fibrose/metabolismo
Fibrose/patologia
Seres Humanos
Cinesina/genética
Cinesina/metabolismo
Camundongos
Mutação
Mutação de Sentido Incorreto
Transtornos da Motilidade Ocular/genética
Músculos Oculomotores/anormalidades
Músculos Oculomotores/patologia
Oftalmoplegia/metabolismo
Oftalmoplegia/patologia
Crânio/fisiopatologia
Tubulina (Proteína)/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (KIF21A protein, human); 0 (TUBB3 protein, human); 0 (Tubulin); EC 3.6.4.4 (Kinesin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx168


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[PMID]:27778456
[Au] Autor:Shields M; Sinkar S; Chan W; Crompton J
[Ad] Endereço:The Royal Adelaide Hospital, Adelaide, SA, Australia.
[Ti] Título:Parinaud syndrome: a 25-year (1991-2016) review of 40 consecutive adult cases.
[So] Source:Acta Ophthalmol;95(8):e792-e793, 2017 Dec.
[Is] ISSN:1755-3768
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To characterize the clinical features, aetiology and management of ophthalmic symptoms in adult patients with Parinaud syndrome. METHODS: This is a retrospective, non-comparative observational case series. We reviewed 40 consecutive charts of adult patients with the clinical diagnosis of Parinaud syndrome at the Royal Adelaide Hospital Department of Ophthalmology in Adelaide, South Australia, between 1991 and 2016. Charts were reviewed for the following: (1) demographic information, (2) clinical presentation, (3) neuro-ophthalmology signs, (4) aetiology of Parinaud syndrome, and (5) management. Examination findings were collected at initial evaluation, throughout the course of follow-up, and at last follow-up. RESULTS: All the cases were assessed by one of the authors (JLC). The commonest presenting symptoms were diplopia (67.5%) and blurred vision (25%) followed by visual field defect (12.5%), ataxia (7.5%) and manifest squint (7.5%). The commonest presenting signs were vertical gaze palsy (100%), convergence-retraction nystagmus (87.5%) and light-near dissociation (65.0%). Only 65.0% patients had the classical triad of vertical gaze palsy, convergence-retraction nystagmus and light-near dissociation. Midbrain pathologies including haemorrhage (30.0%), infarction (20.0%) and tumour (15.0%) were the commonest aetiology. Pineal region tumours accounted for 30.0% of presentations. Symptoms were managed conservatively in 45% of cases with temporary occlusion, prisms or refractive correction, and observation in 42.5% of cases. Surgical intervention for refractory diplopia was required in 12.5% of cases, of which 80% reported symptom resolution following surgery. CONCLUSION: Our series highlights the variable clinical presentation of Parinaud syndrome. The classic triad of conjugate upgaze paralysis, convergence-retraction nystagmus and light-near dissociation was only present in 65% of cases. Pineal neoplasms remain an important aetiological consideration; however, primary midbrain pathology including infarction and haemorrhage constituted the majority of our cases and should be considered in all patients. Conservative management approaches for ocular symptoms are sufficient in most cases although surgical treatment of upgaze palsy can be a useful option in refractory cases.
[Mh] Termos MeSH primário: Gerenciamento Clínico
Movimentos Oculares/fisiologia
Previsões
Neuroimagem/métodos
Transtornos da Motilidade Ocular/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Morbidade/tendências
Transtornos da Motilidade Ocular/epidemiologia
Transtornos da Motilidade Ocular/fisiopatologia
Estudos Retrospectivos
Austrália do Sul/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; OBSERVATIONAL STUDY
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/aos.13283


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[PMID]:28466625
[Au] Autor:Gross I; Gross-Tsur V
[Ad] Endereço:Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.
[Ti] Título:Paroxysmal Tonic Upward Gaze at Adolescence: A Girl with Prader-Willi Syndrome.
[So] Source:Isr Med Assoc J;18(11):703-704, 2016 Nov.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Mh] Termos MeSH primário: Ataxia/diagnóstico
Transtornos dos Movimentos/diagnóstico
Transtornos da Motilidade Ocular/diagnóstico
Síndrome de Prader-Willi/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Ataxia/fisiopatologia
Feminino
Seres Humanos
Transtornos dos Movimentos/fisiopatologia
Transtornos da Motilidade Ocular/fisiopatologia
Síndrome de Prader-Willi/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  4 / 3205 MEDLINE  
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[PMID]:28229606
[Au] Autor:Veselý P; Spurná G; Hanák L; Synek S
[Ti] Título:[Disorders of Simple Binocular Vision in Heterophoria and their Spectacle Correction].
[Ti] Título:Poruchy jednoduchého binokulárního videní u heteroforií a jejich resení brýlovou korekcí..
[So] Source:Cesk Slov Oftalmol;72(6):223-225, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:This study deals with evaluation of binocular vision in group of young subjects without eye pathology. We examined at whole 68 subjects with average age 26 years, median 24 years. The sample was divided into two main groups. Group A contains subjects with far and near ortophoria (at whole 26 subjects = 38 %). Group B contains subjects with binocular vision disorder (at whole 42 subjects). One subject had strabismus. The most frequent non-strabismus disorder of binocular vision was convergence insufficiency (13 subjects = 19 %), simple esophoria (12 subjects = 17 %) and simple exophoria (8 subjects = 12 %). We decreased average distance heterophoria value (from 1.02 to 0.36 cm/m esophoria) and near heterophoria value (from 0.60 to 0.31 cm/m exophoria) after proper sphere-cylindrical correction. Result of our study shows that adequate and actual sphere-cylindrical correction can reduce disorder of simple binocular vision.Key words: simple binocular vision, heterophoria, spectacle lenses, convergence insufficiency.
[Mh] Termos MeSH primário: Óculos
Transtornos da Motilidade Ocular/fisiopatologia
Estrabismo/fisiopatologia
Transtornos da Visão/fisiopatologia
Visão Binocular/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Transtornos da Motilidade Ocular/terapia
Estrabismo/terapia
Transtornos da Visão/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


  5 / 3205 MEDLINE  
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[PMID]:27860481
[Au] Autor:Jordáková J
[Ti] Título:[Ocular Motility Disorders with Diplopia Like the first Symptoms of Paranasal Tumours with Orbital Invasion - a Case Report].
[Ti] Título:Porucha motility bulbu s diplopií jako první príznak tumoru prorustajícího do orbity z vedlejsích dutin nosních..
[So] Source:Cesk Slov Oftalmol;72(4):157-163, 2016.
[Is] ISSN:1211-9059
[Cp] País de publicação:Czech Republic
[La] Idioma:cze
[Ab] Resumo:Presentation of two case reports about our experiences with diagnostics of paranasal tumours in patients with diplopia or ocular motility disorders which were the first symptoms of these tumours. Furthermore, the following diagnostic and therapeutic procedure which has been conducted in cooperation with other hospital departments is presented. The first case report is an example of primary paranasal tumour, the second case report represents secondary infiltration of maxillary sinus and orbital invasion. METHODS: A case reports.Key words: diplopia, paranasal tumours, orbital invasion, spinocellulary carcinoma.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/diagnóstico
Diplopia/diagnóstico
Transtornos da Motilidade Ocular/diagnóstico
Neoplasias Orbitárias/diagnóstico
Neoplasias dos Seios Paranasais/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Evisceração do Olho
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Invasividade Neoplásica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


  6 / 3205 MEDLINE  
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[PMID]:29075763
[Au] Autor:Lee JE; Yang HK; Kim JH; Hwang JM
[Ad] Endereço:Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea.
[Ti] Título:Ocular Torsion According to Trochlear Nerve Absence in Unilateral Superior Oblique Palsy.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5526-5531, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To investigate the relationship between objective ocular torsion and the presence or absence of the trochlear nerve in subjects with unilateral superior oblique palsy (SOP). Methods: A total of 159 subjects with congenital and acquired unilateral SOP were reviewed. Eighty-four subjects who had a normal trochlear nerve (present group) and 75 subjects without a trochlear nerve (absent group) were included. Cyclovertical motility parameters and objective ocular torsion were compared between groups, and factors related to ocular torsion were evaluated. Results: The degree of "net" excyclotorsion in the paretic eye was larger in the absent group compared to the present group (P = 0.002). The proportion of net excyclotorsion in the paretic eye was greater in the absent group (11% vs. 37%), while net incyclotorsion was greater in the present group (41% vs. 23%) (P < 0.001). Net excyclotorsion of the paretic eye was associated with absence of the trochlear nerve (P < 0.001) and smaller size of the paretic SO (P < 0.001). Net incyclotorsion of the paretic eye was related with a normal trochlear nerve (P = 0.005), larger size of the paretic SO (P = 0.002), and greater hypertropia during ipsilateral gaze (P = 0.024). Conclusions: The status of the trochlear nerve, paretic SO size, and hypertropia during ipsilateral gaze which reflects the tensile strength of the ipsilateral superior rectus, significantly contribute to ocular torsion in unilateral SOP.
[Mh] Termos MeSH primário: Movimentos Oculares/fisiologia
Transtornos da Motilidade Ocular/etiologia
Músculos Oculomotores/fisiopatologia
Doenças do Nervo Troclear/congênito
Nervo Troclear/anormalidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Transtornos da Motilidade Ocular/diagnóstico
Transtornos da Motilidade Ocular/fisiopatologia
Músculos Oculomotores/inervação
Estudos Retrospectivos
Nervo Troclear/diagnóstico por imagem
Doenças do Nervo Troclear/complicações
Doenças do Nervo Troclear/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171028
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22452


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[PMID]:28984724
[Au] Autor:Ghannam ASB; Subramanian PS
[Ad] Endereço:aDepartment of Ophthalmology bDepartment of Neurology cDepartment of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
[Ti] Título:Neuro-ophthalmic manifestations of cerebrovascular accidents.
[So] Source:Curr Opin Ophthalmol;28(6):564-572, 2017 Nov.
[Is] ISSN:1531-7021
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Ocular functions can be affected in almost any type of cerebrovascular accident (CVA) creating a burden on the patient and family and limiting functionality. The present review summarizes the different ocular outcomes after stroke, divided into three categories: vision, ocular motility, and visual perception. We also discuss interventions that have been proposed to help restore vision and perception after CVA. RECENT FINDINGS: Interventions that might help expand or compensate for visual field loss and visuospatial neglect include explorative saccade training, prisms, visual restoration therapy (VRT), and transcranial direct current stimulation (tDCS). VRT makes use of neuroplasticity, which has shown efficacy in animal models but remains controversial in human studies. SUMMARY: CVAs can lead to decreased visual acuity, visual field loss, ocular motility abnormalities, and visuospatial perception deficits. Although ocular motility problems can be corrected with surgery, vision, and perception deficits are more difficult to overcome. Interventions to restore or compensate for visual field deficits are controversial despite theoretical underpinnings, animal model evidence, and case reports of their efficacies.
[Mh] Termos MeSH primário: Transtornos da Motilidade Ocular/etiologia
Transtornos da Percepção/etiologia
Acidente Vascular Cerebral/complicações
Transtornos da Visão/etiologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Movimentos Oculares/fisiologia
Seres Humanos
Transtornos da Motilidade Ocular/fisiopatologia
Transtornos da Motilidade Ocular/terapia
Transtornos da Percepção/fisiopatologia
Transtornos da Percepção/terapia
Acidente Vascular Cerebral/fisiopatologia
Acidente Vascular Cerebral/terapia
Estimulação Transcraniana por Corrente Contínua
Transtornos da Visão/fisiopatologia
Transtornos da Visão/terapia
Acuidade Visual/fisiologia
Campos Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/ICU.0000000000000414


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[PMID]:28767569
[Au] Autor:Lee SH; Chung I; Choi DS; Shin IW; Kim S; Kang S; Kim JY; Chung YK; Sohn JT
[Ad] Endereço:aDepartment of Anesthesiology and Pain Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital bDepartment of Ophthalmology, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital cDepartment of Radiology & Gyeongnam Cerebrovascular Center, Gyeongsang National University Hospital dInstitute of Health Sciences, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, Republic of Korea.
[Ti] Título:Visual loss due to optic nerve infarction and central retinal artery occlusion after spine surgery in the prone position: A case report.
[So] Source:Medicine (Baltimore);96(31):e7379, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Visual loss after spine surgery in the prone position is a serious complication. Several cases of central retinal artery occlusion with ophthalmoplegia after spine surgery have been reported in patients with ophthalmic arteries fed by the internal carotid artery (ICA) in a normal manner. PATIENT CONCERNS: A 74-year-old man developed visual loss after undergoing a spinal decompression and fusion operation in the prone position that lasted approximately 5 hours. DIAGNOSES: We detected an extremely rare case of visual loss due to optic nerve infarction and central retinal artery occlusion through fundoscopic examination, fluorescein angiogram, brain magnetic resonance imaging, and magnetic resonance angiography. The patient's visual loss may have been caused by compromised retrograde collateral circulation of the ophthalmic artery from branches of the external carotid artery in the presence of proximal ICA occlusion after a spinal operation in the prone position. INTERVENTIONS: To recover movement of the left extraocular muscles, the patient received intravenous injections of methylprednisolone for 3 days and then oral prednisolone for 6 days. OUTCOMES: Twenty days after the treatment, the motion of the left extraocular muscles was significantly improved. However, recovery from the left visual loss did not occur until 4 months after the operation. LESSONS: In high-risk patients with retrograde collateral circulation of the ophthalmic artery from the external carotid artery due to proximal ICA occlusion, various measures, including the use of a head fixator to provide a position completely free of direct compression of the head and face, should be considered to decrease the risk of postoperative visual loss.
[Mh] Termos MeSH primário: Descompressão Cirúrgica
Neuropatia Óptica Isquêmica/etiologia
Complicações Pós-Operatórias
Fusão Vertebral
Transtornos da Visão/etiologia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
Transtornos da Motilidade Ocular/diagnóstico por imagem
Transtornos da Motilidade Ocular/tratamento farmacológico
Transtornos da Motilidade Ocular/etiologia
Neuropatia Óptica Isquêmica/diagnóstico por imagem
Neuropatia Óptica Isquêmica/tratamento farmacológico
Posicionamento do Paciente
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/tratamento farmacológico
Decúbito Ventral
Transtornos da Visão/diagnóstico por imagem
Transtornos da Visão/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007379


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[PMID]:28726664
[Au] Autor:Tkemaladze T; Melikishvili G; Kherkheulidze V; Melikishvili A; Davitaia T
[Ad] Endereço:1MediClubGeorgia Medical Center, Department of Pediatrics; 2Tbilisi State Medical University, Department of Molecular and Medical Genetics; 3St Christopher's Hospital for Children, Philadelphia, PA, U.S.A.; 4M. Iashvili Children Central Hospital, Uronephrology Department, Tbilisi, Georgia.
[Ti] Título:EXPANDED PHENOTYPE OF TMEM67 GENE MUTATION (CASE REPORT).
[So] Source:Georgian Med News;(267):100-103, 2017 Jun.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:Human ciliopathies are a class of multi-organ genetic disorders caused by defects of proteins expressed at the primary cilium, an organelle present on the cell surface of almost all cell types. Thus far, dozens of causative genes for ciliopathies have been identified and many of them are known to cause allelic disease. Of particular interest is the TMEM67 gene, encoding the transmembrane protein meckelin. The involvement of the mutant TMEM67 gene is known to be associated with a broad range of clinical presentations, namely Joubert syndrome 6 (JBTS6), nephronophthisis 11 (NPHP11), Bardet-Biedel syndrome (BBS), COACH syndrome, and lethal Meckel syndrome type 3 (MKS3). Here we present a case of a 3-year-old boy with compound heterozygous missense mutations in the TMEM67 gene manifesting features of both JBTS and NPHP syndromes, with neonatal onset of end-stage renal disease (ESRD) and associated microcephaly. Such a phenotype has not been reported to date, thus highlighting the diversity of ciliopathies and expanding the phenotype of the TMEM67 gene.
[Mh] Termos MeSH primário: Ciliopatias/genética
Proteínas de Membrana/genética
[Mh] Termos MeSH secundário: Doenças Cerebelares/genética
Pré-Escolar
Seres Humanos
Nefropatias/genética
Doenças Renais Císticas/genética
Falência Renal Crônica/genética
Masculino
Microcefalia/genética
Mutação
Transtornos da Motilidade Ocular/genética
Fenótipo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (TMEM67 protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


  10 / 3205 MEDLINE  
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[PMID]:28708670
[Au] Autor:Kelbsch CB; Maeda F; Strasser T; Peters TM; Wilhelm BJC; Wilhelm HM
[Ad] Endereço:Pupil Research Group at the Centre for Ophthalmology (CK, FM, TS, TP, BW, HW), University of Tübingen, Tübingen, Germany; Department of Orthoptics and Visual Sciences (FM), Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata, Japan; and Institute for Ophthalmic Research (TS), University of Tübingen, Tübingen, Germany.
[Ti] Título:Color Pupillography in Dorsal Midbrain Syndrome.
[So] Source:J Neuroophthalmol;37(3):247-252, 2017 Sep.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study was to evaluate the pupil response to chromatic stimuli in patients with lesions in the dorsal midbrain and possibly gain new insights into the afferent pupillary pathways. METHODS: Color pupillography was performed in 5 patients with dorsal midbrain syndrome (DMS), and their results were compared with those of 20 healthy control subjects. We used full-field red stimuli (605 nm) that primarily address the rod/cone system and blue stimuli (420 nm) that preferentially activate intrinsically photosensitive retinal ganglion cells (ipRGCs) directly, with a duration of 4 seconds and a stimulus intensity of 28 lx corneal illumination under mesopic conditions. One eye was stimulated, and the consensual pupil response was recorded and analyzed. RESULTS: The pupillary light reflex in patients with DMS was reduced, differed in shape, and showed a prolonged latency time compared to normal subjects. The blue response was less affected than the red response: the mean maximal relative amplitude (M) was 15.8% (SD = 7.8) in patients with DMS compared with 43.0% (SD = 5.5) in normal subjects for red stimulation, and M = 40.8%, SD = 8.4 (DMS) with M = 58.3%, SD = 4.8 (normals) for blue stimulation. The reduction was 63% for red stimulation but only 30% for blue stimulation in patients with DMS. Moreover, there was a preserved postillumination pupil response to blue stimulation in DMS patients. CONCLUSIONS: In DMS, the melanopsin-mediated ipRGC pathway appeared relatively preserved.
[Mh] Termos MeSH primário: Técnicas de Diagnóstico Oftalmológico
Mesencéfalo/fisiopatologia
Transtornos da Motilidade Ocular/diagnóstico
Pupila/fisiologia
Reflexo Pupilar/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos da Motilidade Ocular/fisiopatologia
Estimulação Luminosa
Opsinas de Bastonetes/metabolismo
Síndrome
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Rod Opsins); 0 (melanopsin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000527



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