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  1 / 10565 MEDLINE  
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[PMID]:29472200
[Au] Autor:Davies BM; Mowforth OD; Smith EK; Kotter MR
[Ad] Endereço:Academic neurosurgery unit, Department of Clinical Neurosurgery, University of Cambridge, Cambridge, UK.
[Ti] Título:Degenerative cervical myelopathy.
[So] Source:BMJ;360:k186, 2018 02 22.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Vértebras Cervicais
Imagem por Ressonância Magnética
Doenças da Medula Espinal/diagnóstico
Doenças da Medula Espinal/terapia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Progressão da Doença
Seres Humanos
Exame Neurológico
Encaminhamento e Consulta
Doenças da Medula Espinal/epidemiologia
Doenças da Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180224
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k186


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[PMID]:29390372
[Au] Autor:Notani N; Miyazaki M; Yoshiiwa T; Ishihara T; Kanezaki S; Tsumura H
[Ad] Endereço:Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, Japan.
[Ti] Título:Dynamic paraspinal muscle impingement causing acute hemiplegia after C1 posterior arch laminectomy: A case report.
[So] Source:Medicine (Baltimore);96(50):e9264, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Acute neurological deficits following spinal surgery commonly result from epidural hematoma, surgical trauma, vascular compromise, and graft or hardware impingement, with the cause identified by magnetic resonance imaging (MRI). We present a rare case of dynamic paraspinal muscle impingement after C1 posterior arch laminectomy, which was diagnosed by myelography, with no significant findings on MRI. PATIENT CONCERNS: An 81-year-old, severely obese male, was referred to our department for the treatment of vertebral disease of the lumbar spine. The patient presented with bilateral weakness and numbness of the upper extremities and gait disturbances. Based on MRI, a diagnosis of retro-odontoid pseudotumor was made, and C1 posterior arch laminectomy, in combination with C4 partial laminectomy and C5 to C6 laminoplasty, was performed. On postoperative day 3, the patient's neurological status deteriorated, with right upper extremity and right lower extremity weakness increasing with neck extension. Although there was no evidence of epidural hematoma formation on MRI, obstruction of the flow of contrast medium by an external posterior compression in neck extension at the level of C1 was identified by myelography. Revision surgery was performed and local muscle swelling at the surgical site identified with no hematoma formation. Occiput to C3 fixation, with instrumentation, was performed. OUTCOMES: Muscle strength of the right upper extremity and lower extremities recovered postsurgery, and the patient has continued to improve function 3 years after surgery, with no further neurological episodes. LESSONS: Dynamic paraspinal muscle impingement following C1 laminectomy in a muscular man was diagnosed by myelography, with no significant findings on standard MRI. CONCLUSION: The possibility of dynamic paraspinal muscle impingement should be considered in patients developing acute, progressive, neurological deficits after posterior cervical decompression, with myelography being the imaging method of choice for diagnosis.
[Mh] Termos MeSH primário: Vértebras Cervicais/cirurgia
Hemiplegia/etiologia
Processo Odontoide/cirurgia
Músculos Paraespinais/cirurgia
Complicações Pós-Operatórias/etiologia
Doenças da Medula Espinal/diagnóstico
Doenças da Medula Espinal/cirurgia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Seres Humanos
Laminectomia
Imagem por Ressonância Magnética
Masculino
Mielografia
Procedimentos Neurocirúrgicos
Recuperação de Função Fisiológica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009264


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[PMID]:29390447
[Au] Autor:Xu JX; Wang CG; Zhou CW; Tang Q; Li JW; Xu HZ; Mao FM; Tian NF
[Ad] Endereço:Zhejiang Spine Research Center, Department of Spine Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
[Ti] Título:Cervical myelopathy caused by invaginated laminae of the axis associated with occipitalizaion of the atlas: Case report and literature review.
[So] Source:Medicine (Baltimore);96(51):e9156, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: In previous studies, few cases of cervical myelopathy caused by invaginated anomalous laminae of the axis have been reported, and none of them was combined with occipitalization of the atlas. PATIENT CONCERNS: A 28-year-old male was brought to our hospital with motor and sensory impairments of the extremities after a car accident. DIAGNOSES: MRI showed the spinal cord was markedly compressed at the C2/3 level. Reconstructed CT scans revealed an invaginated laminae of axis into the spinal canal as well as atlas assimilation. INTERVENTIONS: The patient was successfully managed with surgical treatment by removal of the anomalous osseous structure as well as fixation and fusion. OUTCOMES: The patient had a rapid recovery after the operation. He regained the normal strength of his 4 extremities and the numbness of his extremities disappeared. He returned to his normal work 3 months after the surgery without any symptoms. LESSONS: Invaginated laminae of axis combined with occipitalization of the atlas is a rare deformity. MRI and reconstructed CT scans are useful for both diagnosing and surgical planning of this case. Surgical removal of the laminae results in a satisfactory outcome. The pathogenesis of this anomaly could be the fusion sequence error of the 4 chondrification centers in the embryological term.
[Mh] Termos MeSH primário: Vértebra Cervical Áxis/anormalidades
Vértebra Cervical Áxis/diagnóstico por imagem
Compressão da Medula Espinal/diagnóstico por imagem
Doenças da Medula Espinal/etiologia
[Mh] Termos MeSH secundário: Adulto
Descompressão Cirúrgica
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Compressão da Medula Espinal/cirurgia
Doenças da Medula Espinal/diagnóstico por imagem
Doenças da Medula Espinal/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009156


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[PMID]:29384855
[Au] Autor:Zeng J; Duan Y; Yang Y; Wang B; Hong Y; Lou J; Ning N; Liu H
[Ad] Endereço:Department of Orthopedics.
[Ti] Título:Anterior corpectomy and reconstruction using dynamic cervical plate and titanium mesh cage for cervical spondylotic myelopathy: A minimum 5-year follow-up study.
[So] Source:Medicine (Baltimore);97(5):e9724, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anterior cervical corpectomy and fusion (ACCF) is an effective surgical technique for cervical spondylotic myelopathy (CSM). However, no data exist regarding long-term outcomes after ACCF with the dynamic cervical plate for CSM. This study aimed to provide minimum 5-year clinical and radiographic outcomes of anterior corpectomy and reconstruction using dynamic cervical plate and titanium mesh cage (TMC) for CSM.Thirty-five patients who underwent single- or 2-level ACCF with dynamic cervical plate and TMC for the treatment of CSM were retrospectively investigated. The Japanese Orthopedic Association (JOA) score was used to assess the clinical outcome. Radiographic evaluations included TMC subsidence, fusion status, cervical lordosis, segmental angle, and segmental height.Twenty-eight patients underwent single-level and 7 patients underwent 2-level corpectomy with a mean follow-up period of 69.5 months. The average preoperative JOA score was 11.3 ±â€Š3.0 and improved significantly to 14.2 ±â€Š2.0 at the last follow-up (P < .001). Both cervical lordosis (P = .013) and segmental angle (P = .001) were significantly increased toward lordosis at the last follow-up. The TMC subsidence rate was 31.4% (n = 11) at the last follow-up. There was no significant difference in JOA recovery rate between subsidence and no subsidence group (P = .43). All patients obtained solid fusion at 1-year follow-up.Anterior corpectomy and reconstruction with dynamic cervical plate and TMC might be an effective method for the treatment of CSM at a minimum 5-year follow-up. It can maintain or restore cervical sagittal alignment. Subsidence of the TMC did not influence the clinical outcome.
[Mh] Termos MeSH primário: Placas Ósseas
Vértebras Cervicais/cirurgia
Procedimentos Ortopédicos
Procedimentos Cirúrgicos Reconstrutivos
Doenças da Medula Espinal/cirurgia
Espondilose/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Vértebras Cervicais/diagnóstico por imagem
Feminino
Seguimentos
Seres Humanos
Lordose/diagnóstico por imagem
Lordose/cirurgia
Masculino
Meia-Idade
Complicações Pós-Operatórias
Estudos Retrospectivos
Doenças da Medula Espinal/diagnóstico por imagem
Espondilose/diagnóstico por imagem
Titânio
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
D1JT611TNE (Titanium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009724


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[PMID]:29381941
[Au] Autor:Wang F; Hou HT; Wang P; Zhang JT; Shen Y
[Ad] Endereço:Department of Spine Surgery, The Third Hospital of Hebei Medical University, The Key Laboratory of Orthopedic Biomechanics of Hebei Province.
[Ti] Título:Symptomatic adjacent segment disease after single-lever anterior cervical discectomy and fusion: Incidence and risk factors.
[So] Source:Medicine (Baltimore);96(47):e8663, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to determine the incidence and risk factors of symptomatic adjacent segment disease (ASD) following single-lever anterior cervical discectomy and fusion (ACDF) for cervical degenerative diseases.From January 2000 to December 2010, a total of 582 patients with cervical radiculopathy and myelopathy who had undergone single-lever ACDF surgery in the authors' institution were reviewed retrospectively. Patients who had a revision surgery for symptomatic ASD were selected for this study. The authors analyzed the incidence for ASD after single-lever ACDF. And univariate analysis and logistic regression analysis were performed to identify the risk factors of ASD.Among the 582 patients, 36 patients received subsequent surgical management for ASD after initial single-lever ACDF for an overall prevalence of 6.2%. The average onset time of ASD was 8.5 (2-15) years. The univariate analysis showed that there were no significant differences in sex, duration of disease, BMI, DM, smoking, operative levels, and follow-up period (P > .05) between the 2 groups with and without ASD. There were statistically significant differences in age at the time of operation (χ = 4.361, P = .037), and developmental canal stenosis (χ = 4.181, P = .041) between patients with and without ASD. The variables of age at the time of operation and developmental canal stenosis were included in a logistic regression model. The logistic regression analysis revealed that age at the time of operation ≤50 years (P = .045, OR = 3.015, 95% CI = 1.024-8.882) and developmental canal stenosis (P = .042, OR = 2.797, 95% CI = 1.039-7.527) were the risk factors for ASD after single-lever ACDF.In the present study, the incidence of symptomatic ASD after single-lever ACDF was 6.2%. And the age at the time of operation ≤50 years and developmental canal stenosis were the risk factors for ASD. The patients ≤50 years old at the time of operation or with developmental canal stenosis are more likely to develop ASD after surgery, and the risk of reoperation will increase.
[Mh] Termos MeSH primário: Discotomia/efeitos adversos
Degeneração do Disco Intervertebral
Complicações Pós-Operatórias
Radiculopatia/cirurgia
Reoperação/estatística & dados numéricos
Doenças da Medula Espinal/cirurgia
Fusão Vertebral/efeitos adversos
Estenose Espinal
[Mh] Termos MeSH secundário: Fatores Etários
Vértebras Cervicais/diagnóstico por imagem
Vértebras Cervicais/patologia
Vértebras Cervicais/cirurgia
China/epidemiologia
Discotomia/métodos
Feminino
Seres Humanos
Incidência
Degeneração do Disco Intervertebral/diagnóstico
Degeneração do Disco Intervertebral/epidemiologia
Degeneração do Disco Intervertebral/etiologia
Degeneração do Disco Intervertebral/cirurgia
Masculino
Meia-Idade
Avaliação de Processos e Resultados (Cuidados de Saúde)
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/cirurgia
Estudos Retrospectivos
Fatores de Risco
Fusão Vertebral/métodos
Estenose Espinal/diagnóstico
Estenose Espinal/epidemiologia
Estenose Espinal/etiologia
Estenose Espinal/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008663


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[PMID]:29245216
[Au] Autor:Birnbaum J; Lalji A; Piccione EA; Izbudak I
[Ad] Endereço:aDivision of Rheumatology and Department of Neurology, The Johns Hopkins University School of MedicinebThe Johns Hopkins University School of Medicine, Baltimore, MDcDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NEdDivision of Neuroradiology, Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD.
[Ti] Título:Magnetic resonance imaging of the spinal cord in the evaluation of 3 patients with sensory neuronopathies: Diagnostic assessment, indications of treatment response, and impact of autoimmunity: A case report.
[So] Source:Medicine (Baltimore);96(49):e8483, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Sensory neuronopathy can be a devastating peripheral nervous system disorder. Profound loss in joint position is associated with sensory ataxia, and reflects degeneration of large-sized dorsal root ganglia. Prompt recognition of sensory neuronopathies may constitute a therapeutic window to intervene before there are irreversible deficits. However, nerve-conduction studies may be unrevealing early in the disease course. In such cases, the appearance of dorsal column lesions on spinal-cord MRI can help in the diagnosis. However, most studies have not defined whether such dorsal column lesions may occur within earlier as well as chronic stages of sensory neuronopathies, and whether serial MRI studies can be used to help assess treatment efficacy. In this case-series of three sensory neuronopathy patients, we report clinical characteristics, immunological markers, nerve-conduction and skin-biopsy studies, and neuroimaging features. PATIENT CONCERNS: All three patients presented with characteristic features of sensory neuronopathy with abnormal spinal-cord MRI studies. Radiographic findings included non-enhancing lesions in the dorsal columns that were longitudinally extensive (spanning ≥ 3 vertebral segments). DIAGNOSES: All patients had anti-Ro/SS-A and/or anti-La/SS-B antibodies, with patients one and two having Sjögren's syndrome. MRI findings were similar when performed in the earlier stages of a sensory neuronopathy (patient one, after four months) and chronic stages (patients two and three, after five and three years, respectively). INTERVENTIONS: Patient one was treated with rituximab combined with intravenous immunoglobulin therapy. OUTCOMES: Patient one was initially wheelchair-bound and had improved ambulation after treatment. In this patient, serial MRI studies revealed partial resolution of dorsal column lesions, associated with decreased sensory ataxia and improved nerve-conduction studies. LESSONS: In addition to vitamin B12 and copper deficiency, it is important to include sensory neuronopathies in the differential diagnosis of dorsal column lesions. MRI spinal-cord lesions have similar appearances in the earlier as well as chronic phases of a sensory neuronopathy, and therefore suggest that such dorsal column lesions may reflect inflammatory as well as a gliotic burden of injury. MRI may also be a useful longitudinal indicator of treatment response.
[Mh] Termos MeSH primário: Gânglios Espinais/diagnóstico por imagem
Neuropatias Hereditárias Sensoriais e Autônomas/diagnóstico por imagem
Imagem por Ressonância Magnética
Doenças da Medula Espinal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Anticorpos Antinucleares/sangue
Autoimunidade
Feminino
Neuropatias Hereditárias Sensoriais e Autônomas/imunologia
Seres Humanos
Meia-Idade
Exame Neurológico/métodos
Doenças da Medula Espinal/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (SS-A antibodies); 0 (SS-B antibodies)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008483


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[PMID]:28984755
[Au] Autor:Liu HM; Dong C; Zhang YZ; Tian YY; Chen HX; Zhang S; Li N; Gu P
[Ad] Endereço:aDepartment of Neurology, the First Hospital of Hebei Medical University bBrain Ageing and Cognitive Neuroscience Laboratory of Hebei, Shijiazhuang, Hebei, China.
[Ti] Título:Clinical and imaging features of spinal cord type of neuro Behçet disease: A case report and systematic review.
[So] Source:Medicine (Baltimore);96(40):e7958, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONAL: To investigate the clinical and MRI characteristics of spinal cord nerve Behçet's disease. PATIENT CONCERNS: One patient with spinal cord nerve Behçet's disease was admitted to our hospital at October 20, 2015. DIAGNOSE: Spinal cord nerve Behçet's disease. INTERVENTIONS: Retrospective analysis was performed on such case as well as 16 cases of spinal cord nerve Behçet's disease reported in China or abroad. OUTCOMES: Seventeen cases of spinal cord type of neuro Behçet's disease include 13 men and 4 women, with an average age of onset of 34.8 years old. The mean time from Behçet's disease symptoms to spinal cord involvement were 10.8 years. The initial symptom in one case was spinal cord injury, and another 4 cases had a recurrence course. The most common performance of spinal cord injury was sensory disturbance (82.4%), following by weakness (76.5%), sphincter or sexual dysfunction (58.8%), and pain in back, backside of neck or lower chest (29.4%). The number of cells was slightly increased or the protein level was increased in cerebrospinal fluid test. And the water channel protein antibody and oligoclonal band of serum levels were all negative. The spinal cord injury involved more than 3 vertebral bodies in 10 cases, and involved more than half of spinal cord in sagittal plane in 8 cases. In acute stage, shock therapy with large dose of glucocorticoid was generally applied both in China and abroad. LESSONS: The clinical features of spinal cord nerve Behçet's disease were various, making it easily misdiagnosed. Longitudinal extensive transverse myelitis performs as a characteristic manifestation.
[Mh] Termos MeSH primário: Síndrome de Behçet/diagnóstico por imagem
Síndrome de Behçet/patologia
Imagem por Ressonância Magnética/métodos
Doenças da Medula Espinal/diagnóstico por imagem
Doenças da Medula Espinal/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Síndrome de Behçet/complicações
Síndrome de Behçet/etiologia
China
Erros de Diagnóstico
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Medula Espinal/diagnóstico por imagem
Medula Espinal/patologia
Doenças da Medula Espinal/etiologia
Traumatismos da Medula Espinal/diagnóstico por imagem
Traumatismos da Medula Espinal/etiologia
Traumatismos da Medula Espinal/patologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007958


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[PMID]:28977080
[Au] Autor:Salomão R; Canêdo NHS; Abrão GP; Lima C; Acioly MA
[Ad] Endereço:Division of Neurosurgery, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
[Ti] Título:Foix-Alajouanine syndrome mimicking a spinal cord tumor.
[So] Source:Rev Assoc Med Bras (1992);63(7):564-565, 2017 Jul.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Subacute necrotizing myelopathy (SNM) or Foix-Alajouanine syndrome is a rare disease characterized by progressive neurological dysfunction caused by a spinal dural arteriovenous fistula (AVF). Radiological diagnosis is usually suspected when there is intramedullary nonspecific enhancement and perimedullary flow voids. Ring-enhancement is rarely reported in the scope of AVF, which poses a diagnostic challenge and raises the suspicion of a spinal cord tumor. In such situations, biopsy can be required and delay proper diagnosis. We report the case of a patient with SNM, who underwent biopsy on the assumption of it being a spinal cord tumor.
[Mh] Termos MeSH primário: Fístula Arteriovenosa/diagnóstico por imagem
Doenças da Medula Espinal/diagnóstico por imagem
Neoplasias da Medula Espinal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Angiografia
Fístula Arteriovenosa/patologia
Biópsia
Diagnóstico Diferencial
Feminino
Seres Humanos
Medula Espinal/diagnóstico por imagem
Medula Espinal/patologia
Doenças da Medula Espinal/patologia
Doenças da Medula Espinal/cirurgia
Neoplasias da Medula Espinal/patologia
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE


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[PMID]:28939758
[Au] Autor:Sorcini D; Bruscoli S; Frammartino T; Cimino M; Mazzon E; Galuppo M; Bramanti P; Al-Banchaabouchi M; Farley D; Ermakova O; Britanova O; Izraelson M; Chudakov D; Biagioli M; Sportoletti P; Flamini S; Raspa M; Scavizzi F; Nerlov C; Migliorati G; Riccardi C; Bereshchenko O
[Ad] Endereço:Department of Medicine, University of Perugia, Perugia 06132, Italy.
[Ti] Título:Wnt/ß-Catenin Signaling Induces Integrin α4ß1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.
[So] Source:J Immunol;199(9):3031-3041, 2017 Nov 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mechanisms leading to autoimmune and inflammatory diseases in the CNS have not been elucidated. The environmental triggers of the aberrant presence of CD4 T cells in the CNS are not known. In this article, we report that abnormal ß-catenin expression in T cells drives a fatal neuroinflammatory disease in mice that is characterized by CNS infiltration of T cells, glial activation, and progressive loss of motor function. We show that enhanced ß-catenin expression in T cells leads to aberrant and Th1-biased T cell activation, enhanced expression of integrin α4ß1, and infiltration of activated T cells into the spinal cord, without affecting regulatory T cell function. Importantly, expression of ß-catenin in mature naive T cells was sufficient to drive integrin α4ß1 expression and CNS migration, whereas pharmacologic inhibition of integrin α4ß1 reduced the abnormal T cell presence in the CNS of ß-catenin-expressing mice. Together, these results implicate deregulation of the Wnt/ß-catenin pathway in CNS inflammation and suggest novel therapeutic strategies for neuroinflammatory disorders.
[Mh] Termos MeSH primário: Integrina alfa4beta1/imunologia
Doenças da Medula Espinal/imunologia
Medula Espinal/imunologia
Células Th1/imunologia
Via de Sinalização Wnt/imunologia
beta Catenina/imunologia
[Mh] Termos MeSH secundário: Animais
Inflamação/genética
Inflamação/imunologia
Inflamação/patologia
Integrina alfa4beta1/genética
Camundongos
Camundongos Knockout
Medula Espinal/patologia
Doenças da Medula Espinal/genética
Doenças da Medula Espinal/patologia
Células Th1/patologia
Via de Sinalização Wnt/genética
beta Catenina/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Integrin alpha4beta1); 0 (beta Catenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700247


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[PMID]:28904658
[Au] Autor:Bouchahda H; El Mhabrech H; Hamouda HB; Ghanmi S; Bouchahda R; Soua H
[Ad] Endereço:Department of Gynecology Obstetric, University of Monastir, Tahar Sfar University Hospital, 5111 Mahdia, Tunisia.
[Ti] Título:Prenatal diagnosis of caudal regression syndrome and omphalocele in a fetus of a diabetic mother.
[So] Source:Pan Afr Med J;27:128, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:The caudal regression syndrome is defined as total or partial agenesis of the sacrum and lumbar spine, frequently associated with other developmental malformations (orthopedic, neurological, genito-urinary, gastrointestinal…). Prenatal diagnosis is possible through fetal ultrasound (US) and magnetic resonance imaging (MRI). A case of fetal caudal regression syndrome with omphalocele from a diabetic mother is presented, demonstrating the sonographic, MRI, CT and X-Ray features diagnostic. We will also discuss neonatal findings, risk factors and prognosis of this condition.
[Mh] Termos MeSH primário: Hérnia Umbilical/diagnóstico por imagem
Vértebras Lombares/diagnóstico por imagem
Diagnóstico Pré-Natal/métodos
Sacro/anormalidades
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Vértebras Lombares/anormalidades
Imagem por Ressonância Magnética/métodos
Gravidez
Gravidez em Diabéticas
Prognóstico
Fatores de Risco
Sacro/diagnóstico por imagem
Doenças da Medula Espinal/diagnóstico por imagem
Síndrome
Ultrassonografia Pré-Natal/métodos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.128.12041



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