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[PMID]:29499674
[Au] Autor:Casas P; Ascaso FJ; Vicente E; Tejero-Garcés G; Adiego MI; Cristóbal JA
[Ad] Endereço:Department of Ophthalmology, Hospital Clínico Universitario "Lozano Blesa", San Juan Bosco 15, ES-50009, Zaragoza, Spain. paulacasaspascual@hotmail.com.
[Ti] Título:Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls.
[So] Source:BMC Ophthalmol;18(1):66, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT). METHODS: This prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients. RESULTS: OSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters. We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024). CONCLUSIONS: Retinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Doenças do Nervo Óptico/etiologia
Células Ganglionares da Retina/patologia
Apneia Obstrutiva do Sono/complicações
Transtornos da Visão/etiologia
Campos Visuais
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/diagnóstico
Estudos Prospectivos
Apneia Obstrutiva do Sono/diagnóstico
Tomografia de Coerência Óptica
Transtornos da Visão/diagnóstico
Testes de Campo Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0728-z


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[PMID]:29390337
[Au] Autor:González Saldaña N; Galvis Trujillo DM; Borbolla Pertierra AM; Mondragón Pineda AI; Juárez Olguín H
[Ad] Endereço:Department of Infectology, National Institute of Pediatrics.
[Ti] Título:Linezolid-associated optic neuropathy in a pediatric patient with Mycobacterium nonchromogenicum: A case report.
[So] Source:Medicine (Baltimore);96(50):e9200, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Toxic optic neuropathies are alterations of the optic nerve and can be caused by environmental, pharmacological, or nutritional agents. CASE: It is about a 7-year-old male patient, a native of the State of Mexico, Mexico who was diagnosed with cervical mycobacterial lymphadenitis that required management with linezolid. OBSERVATIONS: After 7 months of treatment, visual acuity of the left eye decreased and was accompanied by headache. Neuroinfection and other central nervous system affections were discarded. An adverse effect related to treatment with linezolid was suspected, and linezolid was suspended. The symptoms subsided after discontinuation; however, the patient continued to show decreased visual acuity of the left eye, assessed by his ability to count 2 fingers. The right eye remained unaffected. CONCLUSIONS: Neurotoxicity can be decreased by reducing the total dose of linezolid or by administrating it in an intermittent form. To avoid progression and loss of vision, we suggest frequent periodic ophthalmological evaluation in patients treated with linezolid.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Linezolida/efeitos adversos
Linfadenite/tratamento farmacológico
Linfadenite/microbiologia
Infecções por Micobactéria não Tuberculosa/tratamento farmacológico
Infecções por Micobactéria não Tuberculosa/microbiologia
Doenças do Nervo Óptico/induzido quimicamente
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Masculino
Micobactérias não Tuberculosas
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); ISQ9I6J12J (Linezolid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009200


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[PMID]:29397523
[Au] Autor:Robson AG; Nilsson J; Li S; Jalali S; Fulton AB; Tormene AP; Holder GE; Brodie SE
[Ad] Endereço:Department of Electrophysiology, Moorfields Eye Hospital, 162 City Road, London, UK. anthony.robson@moorfields.nhs.uk.
[Ti] Título:ISCEV guide to visual electrodiagnostic procedures.
[So] Source:Doc Ophthalmol;136(1):1-26, 2018 02.
[Is] ISSN:1573-2622
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Clinical electrophysiological testing of the visual system incorporates a range of noninvasive tests and provides an objective indication of function relating to different locations and cell types within the visual system. This document developed by the International Society for Clinical Electrophysiology of Vision provides an introduction to standard visual electrodiagnostic procedures in widespread use including the full-field electroretinogram (ERG), the pattern electroretinogram (pattern ERG or PERG), the multifocal electroretinogram (multifocal ERG or mfERG), the electrooculogram (EOG) and the cortical-derived visual evoked potential (VEP). The guideline outlines the basic principles of testing. Common clinical presentations and symptoms are described with illustrative examples and suggested investigation strategies.
[Mh] Termos MeSH primário: Eletrodiagnóstico/normas
Eletroculografia
Eletrofisiologia/organização & administração
Eletrorretinografia/métodos
Potenciais Evocados Visuais
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Seres Humanos
Agências Internacionais
Doenças do Nervo Óptico/diagnóstico
Doenças Retinianas/diagnóstico
Sociedades Médicas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180205
[St] Status:MEDLINE
[do] DOI:10.1007/s10633-017-9621-y


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[PMID]:29381959
[Au] Autor:Wu PC; Tien PT; Li YH; Chen RY; Cho DY
[Ad] Endereço:Division of Rheumatology and Immunology, Department of Internal Medicine, China Medical University Hospital.
[Ti] Título:IgG4-related cerebral pseudotumor with perineural spreading along branches of the trigeminal nerves causing compressive optic neuropathy: A case report.
[So] Source:Medicine (Baltimore);96(47):e8709, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is characterized by tumor-like lesions, a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has been described in a variety of organ systems; however, it rarely involves the central nervous system. PATIENT CONCERNS: A 17-year-old woman visited our clinic with a complaint of blurred vision for the past 5 months. She also reported a painless right submandibular mass that had been present for 1 year. Her best-corrected visual acuity (BCVA) was 2.0 LogMAR, with an almost total visual field defect in the right eye. DIAGNOSES: Magnetic resonance imaging (MRI) revealed lobulated parasellar tumors with perineural spreading along branches of the trigeminal nerves causing right optic nerve compression. A craniotomy with tumor removal and submandibular gland biopsy was performed. Histopathological analysis of the tumor revealed stromal fibrosis with atypical lymphoid infiltrations. Histopathological and immunohistochemical analysis of the submandibular gland confirmed the diagnosis of IgG4-RD. INTERVENTIONS: The patient was administered 500mg/d of pulse methylprednisolone for 3 days, 500mg of intravenous rituximab every 2 weeks (for a total of 2 doses), and 500mg of intravenous pulse cyclophosphamide every month (for a total of 3 doses). OUTCOMES: Two months after the initiation of immunosuppressive therapy, the patient's BCVA returned to 0.1 LogMAR with visual field defect recovery. The follow-up MRI showed the almost complete disappearance of the previously contrast-enhanced lesions. LESSONS: Herein, we report a rare case of IgG4-RD presenting as a parasellar tumor and present a review of the related literature. Based on the case report, we propose that aggressive therapy with glucocorticoid, rituximab, and cyclophosphamide may potentially be useful for treating such cases.
[Mh] Termos MeSH primário: Imunoglobulina G/imunologia
Doenças do Nervo Óptico/imunologia
Pseudotumor Cerebral/imunologia
Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Metilprednisolona/uso terapêutico
Doenças do Nervo Óptico/tratamento farmacológico
Doenças do Nervo Óptico/cirurgia
Pseudotumor Cerebral/tratamento farmacológico
Pseudotumor Cerebral/cirurgia
Rituximab/uso terapêutico
Glândula Submandibular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 4F4X42SYQ6 (Rituximab); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008709


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[PMID]:29242987
[Au] Autor:Baneke AJ; Williams KM; Mahroo OA; Mohamed M; Hammond CJ
[Ad] Endereço:Department of Ophthalmology, King's College London, St Thomas' Hospital Campus, Westminster Bridge Road, London, SE1 7EH, UK. alexbaneke@yahoo.co.uk.
[Ti] Título:A twin study of cilioretinal arteries, tilted discs and situs inversus.
[So] Source:Graefes Arch Clin Exp Ophthalmol;256(2):333-340, 2018 Feb.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To establish the prevalence and heritability of cilioretinal arteries (CRAs), tilted discs (TDs) and situs inversus (SI). METHODS: Fundus photos from the Twins UK Adult Twin registry twin database were analyzed: 1812 individuals, 526 complete monozygotic (MZ) twin pairs and 336 complete dizygotic (DZ) pairs. Images were assessed non-stereoscopically on a computer screen by the same ophthalmologist for presence of CRAs, TDs or SI. Prevalence figures, probandwise concordances and heritabilities were calculated. RESULTS: Prevalence of a CRA in subjects' right eyes was 28.6% (26.5-30.8). Prevalence of subjects with a CRA in at least one eye was 45.0% (42.6-47.5), with a TD in at least one eye was 1.2% (0.8-1.9), and with SI at least one eye was 0.5% (0.3-1.0). There was no association between birth weight and presence of CRA. Concordance for CRA in at least one eye (MZ twins) was 60% (95% CI 55-64), and (DZ) was 45% (95% CI 39-51). Heritability for CRAs in at least one eye was 49.4% (95% CI 38.1-59.7) and for both eyes was 32.9% (95% CI 10.4-53.3). We were unable to calculate meaningful heritabilities or concordances for TDs and situs SI, due to insufficient numbers. CONCLUSIONS: The presence of CRAs appears to be moderately heritable, with greater variance explained by individual environmental factors or even stochastic events. They were not associated with low birth weight. Future genetic research and studies of birth/lifecourse cohorts may offer further insights into the etiology of congenital papillovascular abnormalities.
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Artérias Ciliares/patologia
Doenças em Gêmeos/genética
Disco Óptico/anormalidades
Doenças do Nervo Óptico/genética
Artéria Retiniana/patologia
Situs Inversus/genética
[Mh] Termos MeSH secundário: Doenças em Gêmeos/diagnóstico
Feminino
Predisposição Genética para Doença
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/diagnóstico
Sistema de Registros
Situs Inversus/diagnóstico
Gêmeos Monozigóticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; TWIN STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3859-7


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[PMID]:28452838
[Au] Autor:Cheng YC; Shen JH; Chao AN; Chen KJ
[Ad] Endereço:Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tayouan, Taiwan.
[Ti] Título:Later Development of Posterior Staphyloma in Choroidal Osteoma With Choroidal Neovascularization.
[So] Source:Retina;37(8):e95-e96, 2017 Aug.
[Is] ISSN:1539-2864
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Coristoma/complicações
Neoplasias da Coroide/complicações
Neovascularização de Coroide/complicações
Disco Óptico/patologia
Doenças do Nervo Óptico/etiologia
Osteoma/complicações
[Mh] Termos MeSH secundário: Coristoma/diagnóstico
Corioide/patologia
Neoplasias da Coroide/diagnóstico
Neovascularização de Coroide/diagnóstico
Diagnóstico Diferencial
Angiofluoresceinografia
Seguimentos
Fundo de Olho
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/diagnóstico
Osteoma/diagnóstico
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1097/IAE.0000000000001683


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[PMID]:29238020
[Au] Autor:Tsumura Y; Masuda H; Nishina S; Kobayashi T; Ono H; Kato H; Abe J; Ishiguro A
[Ad] Endereço:National Center for Child Health and Development, Department of Postgraduate Education and Training.
[Ti] Título:[Prolonged optic disc swelling in Kawasaki disease - A case report and literature review].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(5):377-381, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  Kawasaki disease (KD), an acute childhood panvasculitis, presents a variety of ocular complications as well as conjunctival injection among the principal symptoms. However, most pediatricians are unfamiliar with the ophthalmological complications of KD. A 2-year-old girl was referred to us from the ophthalmology department due to injected bulbar conjunctivae and optic disc swelling. She had familial exudative vitreoretinopathy as an underlying disease and the ocular findings had been made by chance while the patient was receiving an eye examination. Although she was afebrile at the time of her first medical interview, KD was diagnosed based on the presence of four of the principal symptoms including fever and dilatation of the coronary arteries. Intravenous immunoglobulin (IVIG) therapy was administered on Day 15 from the onset of fever. After IVIG administration, her laboratory test results showed rapid improvement but her optic disc swelling continued for six months. Eye complications in KD generally occur in the anterior segment, and recovery occurs within two months. Past reports have shown that in three of seven KD cases with optic disc involvement, optic disc swelling lasted over two months. This is the second case in which the condition lasted six months.
[Mh] Termos MeSH primário: Síndrome de Linfonodos Mucocutâneos/complicações
Disco Óptico/patologia
Doenças do Nervo Óptico/etiologia
Doenças do Nervo Óptico/patologia
[Mh] Termos MeSH secundário: Pré-Escolar
Túnica Conjuntiva/patologia
Feminino
Seres Humanos
Imunoglobulinas Intravenosas/administração & dosagem
Achados Incidentais
Síndrome de Linfonodos Mucocutâneos/terapia
Fatores de Tempo
Resultado do Tratamento
Vitreorretinopatia Proliferativa/complicações
Vitreorretinopatia Proliferativa/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.377


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[PMID]:29261845
[Au] Autor:Lee WJ; Kim YK; Park KH; Jeoung JW
[Ad] Endereço:Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:Evaluation of Ganglion Cell-Inner Plexiform Layer Thinning in Eyes With Optic Disc Hemorrhage: A Trend-Based Progression Analysis.
[So] Source:Invest Ophthalmol Vis Sci;58(14):6449-6456, 2017 Dec 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate the rate of change in ganglion cell-inner plexiform layer (GCIPL) thickness measured by optical coherence tomography (OCT) using a trend-based approach in early-stage glaucomatous eyes with disc hemorrhage (DH) and to compare the GCIPL thinning rate with that in glaucomatous eyes without DH. Methods: This prospective observational study included 46 patients with early-stage open-angle glaucoma and DH who underwent serial spectral-domain OCT measurements for at least 30 months. The GCIPL thinning rate was determined in the global, superior, or inferior hemiretinas and in six macular sectors by linear regression and was compared between glaucomatous eyes with DH and fellow glaucomatous eyes without DH and between glaucomatous eyes with DH and non-DH glaucomatous control eyes. Results: The GCIPL thinning rate (mean ± standard deviation) was significantly more rapid in glaucomatous eyes with DH than in fellow eyes without DH in the inferior hemiretina (-1.07 ± 0.75 vs. -0.44 ± 0.54 µm/y, P = 0.001), inferotemporal sector (-1.13 ± 1.00 vs. -0.61 ± 0.66 µm/y, P = 0.028), and inferior sector (-1.33 ± 0.79 vs. -0.42 ± 0.78 µm/y, P < 0.001). The GCIPL thinning rate was significantly more rapid in glaucomatous eyes with DH than in glaucomatous controls without DH in the global area (-0.78 ± 0.85 vs. -0.32 ± 0.48 µm/y, P = 0.002), the inferior hemiretina (-1.00 ± 0.94 vs. -0.37 ± 0.67 µm/y, P < 0.001), and the inferotemporal sector (-1.31 ± 1.07 vs. -0.34 ± 0.75 µm/y, P < 0.001). Conclusions: The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH. DH could be associated with progression of glaucoma in terms of GCIPL thinning.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Aberto/diagnóstico
Disco Óptico/irrigação sanguínea
Doenças do Nervo Óptico/diagnóstico
Hemorragia Retiniana/diagnóstico
Segmento Interno das Células Fotorreceptoras da Retina/patologia
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Progressão da Doença
Seguimentos
Glaucoma de Ângulo Aberto/fisiopatologia
Seres Humanos
Pressão Intraocular
Fibras Nervosas/patologia
Disco Óptico/patologia
Doenças do Nervo Óptico/etiologia
Estudos Prospectivos
Hemorragia Retiniana/etiologia
Acuidade Visual
Campos Visuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22547


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[PMID]:29217027
[Au] Autor:Ozturker ZK; Munro K; Gupta N
[Ad] Endereço:Glaucoma Unit, University of Toronto, Toronto, Ont.; Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ont.
[Ti] Título:Optic disc hemorrhages in glaucoma and common clinical features.
[So] Source:Can J Ophthalmol;52(6):583-591, 2017 Dec.
[Is] ISSN:1715-3360
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze optic nerve head stereophotographs for the presence of optic disc hemorrhages, and to describe bleeding patterns and patient characteristics. DESIGN: Retrospective, cross-sectional study. PARTICIPANTS: 1113 optic nerve stereophotograph pairs of 562 consecutive patients. METHODS: Stereophotographs were systematically reviewed for the presence of a disc hemorrhage with careful documentation of optic nerve head features. All charts of patients with hemorrhage were subsequently studied for demographic information and clinical data. RESULTS: Disc hemorrhages were observed in 7.1% of patients with optic disc photography. Most patients had open-angle glaucoma (57.5%) with focal ischemic phenotype of the optic disc (66.7%). The mean vertical and horizontal cup-disc ratios were 0.82 ± 0.14 and 0.76 ± 0.14, respectively. The ß-zone peripapillary atrophy was observed in 48.9% of patients. The most common location was the inferotemporal region of the disc (60.8%), and most were flame or splinter shaped (70.6%). Disc hemorrhages were found either superficial to or within the retinal nerve fibre layer (72.5%), and in association with a notch (64.4%). The average intraocular pressure was 17.3 ± 4.9 mm Hg, and most hemorrhages were associated with early visual field defects (42.5%). CONCLUSIONS: Optic disc hemorrhages in patients with glaucoma were most frequently observed inferiorly in association with a notch. Most eyes with a disc hemorrhage had an intraocular pressure within normal range and had either early or no visual field loss. These findings highlight the importance of careful examination of the optic nerve head to look for the presence of a disc hemorrhage as an important biomarker of glaucoma damage.
[Mh] Termos MeSH primário: Glaucoma de Ângulo Fechado/diagnóstico
Glaucoma de Ângulo Aberto/diagnóstico
Glaucoma de Baixa Tensão/diagnóstico
Disco Óptico/patologia
Doenças do Nervo Óptico/diagnóstico
Hemorragia Retiniana/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Seres Humanos
Pressão Intraocular
Masculino
Meia-Idade
Doenças do Nervo Óptico/classificação
Fotografia
Estudos Retrospectivos
Tonometria Ocular
Campos Visuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29187926
[Au] Autor:Daldoul N; Knani L; Gatfaoui F; Mahjoub H
[Ad] Endereço:Service d'Ophtalmologie, CHU Farhat Hached, Sousse, Tunisie.
[Ti] Título:[Management of moderate and severe dysthyroid orbitopathy: about 22 cases].
[Ti] Título:Prise en charge des orbitopathies dysthyroidiennes modérées et sévères: à propos de 22 cas..
[So] Source:Pan Afr Med J;27:257, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Our study aimed to describe the therapeutic management of moderate and severe dysthyroid orbitopathies and to evaluate the factors associated with optic neuropathy as well as the prognostic factors of poor visual outcome using a statistical analysis. We conducted a retrospective study of 22 patients presenting with moderate to severe dysthyroid orbitopathy in at least one eye and hospitalized in the Department of Ophthalmology at the University Hospital Farhat Hached, Sousse over the period from 1998 to 2015. Therapeutic indications were based on activity and severity criteria of the Eugogo (European Group On Graves' Orbitopathy) as well as on the assessment of prognostic factors of poor visual outcome. The average age of our patients was 40 years, with a slight male predominance (54.5%). 68.2% of patients were euthyroid, 18.2% had a history of smoking. The most significantly associated factor with neuropathy was a compression in the orbital apex (p = 0.03). Treatment was based on intravenous corticosteroid therapy and/or orbital decompression based on disease activity and severity. Overall evolution after treatment was marked by an improvement in inflammatory signs and by the reduction of exophthalmia. Visual prognosis was worse in elderly patients (p = 0.0001), male sex (p = 0.03) and treated by iratherapy (p = 0.04). Given the limits of a retrospective study, our results were generally consistent with the literature. The assessment and the management of dysthyroid orbitopathy are not well understood. Cohort, probably multicenter studies should be conducted to improve its management.
[Mh] Termos MeSH primário: Exoftalmia/terapia
Oftalmopatia de Graves/terapia
Doenças do Nervo Óptico/terapia
[Mh] Termos MeSH secundário: Administração Intravenosa
Corticosteroides/administração & dosagem
Adulto
Fatores Etários
Idoso
Descompressão Cirúrgica/métodos
Exoftalmia/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças do Nervo Óptico/etiologia
Prognóstico
Estudos Retrospectivos
Índice de Gravidade de Doença
Resultado do Tratamento
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.257.13008



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