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[PMID]:29298687
[Au] Autor:Aojula A; Mollan SP; Horsburgh J; Yiangou A; Markey KA; Mitchell JL; Scotton WJ; Keane PA; Sinclair AJ
[Ad] Endereço:Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT, Birmingham, UK.
[Ti] Título:Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension.
[So] Source:BMC Ophthalmol;17(1):257, 2018 Jan 04.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. METHODS: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined. The internal limiting membrane and RNFL thickness of the most severely affected eye was examined for SegE and re-segmented. Using ImageJ, the total area of the RNFL thickness was calculated pre and post re-segmentation and the percentage change was determined. The distribution of RNFL thickness error was qualitatively assessed. RESULTS: Significantly greater SegE (p = 0.009) was present in RNFL thickness total area, assessed using ImageJ, in IIH patients (n = 46, 5% ± 0-58%) compared to controls (n = 14, 1% ± 0-6%). This was particularly evident in moderate to severe optic disc swelling (n = 23, 10% ± 0-58%, p < 0.001). RNFL thickness was unable to be quantified using SDOCT in patients with severe papilloedema. CONCLUSIONS: SegE remain a concern for clinicians using SDOCT to monitor papilloedema in IIH, particularly in the assessment of eyes with moderate to severe oedema. Systematic assessment and manual refinement of SegE is therefore important to ensure the accuracy in longitudinal monitoring of patients.
[Mh] Termos MeSH primário: Fibras Nervosas/patologia
Disco Óptico/patologia
Papiledema/diagnóstico
Pseudotumor Cerebral/diagnóstico
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica/métodos
Campos Visuais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Papiledema/etiologia
Papiledema/fisiopatologia
Pseudotumor Cerebral/complicações
Pseudotumor Cerebral/fisiopatologia
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0652-7


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[PMID]:29420144
[Au] Autor:Gilbert AL; Chwalisz B; Mallery R
[Ad] Endereço:a Department of Neuro-Ophthalmology , Massachusetts Eye & Ear, Harvard Medical School , Boston , MA , USA.
[Ti] Título:Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension.
[So] Source:Semin Ophthalmol;33(1):36-41, 2018.
[Is] ISSN:1744-5205
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There are a number of surgical options for treatment of idiopathic intracranial hypertension (IIH) when it is refractory to medical treatment and weight loss. Optic nerve sheath fenestration (ONSF) is one of these options. Use of this procedure varies among centers due to experience with the procedure and concern for associated complications that can result in severe loss of vision. This review summarizes the literature concerning post-surgical complications of ONSF for IIH.
[Mh] Termos MeSH primário: Cegueira
Descompressão Cirúrgica/efeitos adversos
Procedimentos Neurocirúrgicos/efeitos adversos
Traumatismos do Nervo Óptico/etiologia
Nervo Óptico/cirurgia
Papiledema/cirurgia
Pseudotumor Cerebral/complicações
[Mh] Termos MeSH secundário: Cegueira/epidemiologia
Cegueira/etiologia
Cegueira/fisiopatologia
Seres Humanos
Nervo Óptico/patologia
Traumatismos do Nervo Óptico/diagnóstico
Traumatismos do Nervo Óptico/fisiopatologia
Papiledema/diagnóstico
Papiledema/etiologia
Complicações Pós-Operatórias
Pseudotumor Cerebral/fisiopatologia
Pseudotumor Cerebral/cirurgia
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1080/08820538.2017.1353810


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[PMID]:28926646
[Au] Autor:Chen TC; Yeh CY; Lin CW; Yang CM; Yang CH; Lin IH; Chen PY; Cheng JY; Hu FR
[Ad] Endereço:Department of Ophthalmology, College of Medicine, National Taiwan University, Taipei, Taiwan.
[Ti] Título:Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases.
[So] Source:PLoS One;12(9):e0184927, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON). METHODS: This three-year cohort study was conducted from September 1 2012, to August 31, 2015. Two hundred and forty-one patients with non-glaucomatous acute optic neuropathy were screened, and 42 non-highly myopic patients who had suffered their first episode of unilaterally idiopathic AON were studied. All cases received spectral-domain optical coherence tomography (OCT) examination, general survey, and standard corticosteroid therapy. OCT images were analyzed using a customized MATLAB program for measuring peripapillary choroidal thickness (PCT). Multivariate regression models were constructed to identify factors that are significantly related to peripapillary perfusion. RESULTS: Decreased PCT was found in eyes experiencing AON combined with disc swelling (the ratio of lesion eye PCT/fellow eye PCT was 0.87 ± 0.08; range, from 0.75 to 1.00). In comparison to the healthy fellow eyes, approximately every 26% increase in the thickness of the retinal nerve fiber layer due to axonal swelling was associated with a 10% decreased thickness of PCT. Thinner PCT is also correlated with poorer trough vision, which may lead to poorer final vision. These findings were obvious in patients with optic papillitis but not in patients with retrobulbar neuritis. CONCLUSIONS: Peripapillary vascular hypoperfusion was found in patients experiencing AON combined with disc swelling. These findings are unlike those for other ocular inflammatory diseases but are consistent with cerebral hypoperfusion, which is found in brain demyelinating diseases; thus, these findings may represent a new neurovascular model in this field.
[Mh] Termos MeSH primário: Modelos Biológicos
Neurite Óptica/patologia
[Mh] Termos MeSH secundário: Doença Aguda
Corticosteroides/uso terapêutico
Adulto
Corioide/diagnóstico por imagem
Corioide/fisiologia
Estudos de Coortes
Doenças Desmielinizantes/metabolismo
Doenças Desmielinizantes/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Neurite Óptica/diagnóstico por imagem
Neurite Óptica/tratamento farmacológico
Papiledema/patologia
Análise de Regressão
Retina/patologia
Tomografia de Coerência Óptica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184927


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[PMID]:28780516
[Au] Autor:Chiloiro S; Giampietro A; Bianchi A; Tartaglione T; Capobianco A; Anile C; De Marinis L
[Ad] Endereço:Pituitary UnitDepartment of Endocrinology.
[Ti] Título:DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review.
[So] Source:Eur J Endocrinol;177(6):R275-R285, 2017 Dec.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degrees of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanisms are not well known but seem to be due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in a majority of cases, a neuroradiological findings without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, which delineates from the so called PES syndrome. Headache, irregular menses, overweight/obesity and visual disturbances compose the typical picture of PES syndrome and can be the manifestation of an intracranial hypertension, often associated with PES. Although hyperprolactinemia and growth hormone deficit represent the most common endocrine abnormalities, PES syndrome is characterized by heterogeneity both in clinical manifestation and hormonal alterations and can sometime reach severe extremes, as occurrence of papilledema, cerebrospinal fluid rhinorrhea and worsening of visual acuity. Consequently, a multidisciplinary approach, with the integration of endocrine, neurologic and ophthalmologic expertise, is strongly advocated and recommended for a properly diagnosis, management, treatment and follow-up of PES syndrome and all of the related abnormalities.
[Mh] Termos MeSH primário: Doenças Assintomáticas
Síndrome da Sela Vazia/diagnóstico
Encefalocele/diagnóstico
Hipófise/diagnóstico por imagem
Sela Túrcica/diagnóstico por imagem
Espaço Subaracnóideo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Síndrome da Sela Vazia/diagnóstico por imagem
Síndrome da Sela Vazia/fisiopatologia
Síndrome da Sela Vazia/terapia
Encefalocele/diagnóstico por imagem
Encefalocele/fisiopatologia
Encefalocele/terapia
Hormônio do Crescimento Humano/deficiência
Hormônio do Crescimento Humano/secreção
Seres Humanos
Hiperprolactinemia/etiologia
Hiperprolactinemia/prevenção & controle
Hipertensão Intracraniana/etiologia
Hipertensão Intracraniana/prevenção & controle
Imagem por Ressonância Magnética
Neuroimagem
Papiledema/etiologia
Papiledema/prevenção & controle
Hipófise/fisiopatologia
Hipófise/secreção
Sela Túrcica/fisiopatologia
Índice de Gravidade de Doença
Espaço Subaracnóideo/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
12629-01-5 (Human Growth Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0505


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[PMID]:28727859
[Au] Autor:Lee AG; Mader TH; Gibson CR; Tarver W
[Ad] Endereço:Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas.
[Ti] Título:Space Flight-Associated Neuro-ocular Syndrome.
[So] Source:JAMA Ophthalmol;135(9):992-994, 2017 Sep 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station. These clinical findings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts. The clinical findings of SANS have been correlated with structural changes on intraorbital and intracranial magnetic resonance imaging and in-flight and terrestrial ultrasonographic studies and ocular optical coherence tomography. Further study of SANS is ongoing for consideration of future manned missions to space, including a return trip to the moon or Mars.
[Mh] Termos MeSH primário: Doenças da Coroide/etiologia
Hiperopia/etiologia
Doenças do Nervo Óptico/etiologia
Papiledema/etiologia
Voo Espacial
Transtornos da Visão/etiologia
Ausência de Peso/efeitos adversos
[Mh] Termos MeSH secundário: Astronautas
Doenças da Coroide/diagnóstico
Seres Humanos
Hiperopia/diagnóstico
Pressão Intracraniana
Pressão Intraocular
Imagem por Ressonância Magnética
Fibras Nervosas/patologia
Doenças do Nervo Óptico/diagnóstico
Papiledema/diagnóstico
Células Ganglionares da Retina/patologia
Punção Espinal
Tomografia de Coerência Óptica
Transtornos da Visão/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.2396


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[PMID]:28606265
[Au] Autor:Li B; Ye JJ; Zhang MF; Li DH
[Ad] Endereço:Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China.
[Ti] Título:[The fundus manifestations and SD-OCT findings of patients with acute Vogt-Koyanagi-Harada disease].
[So] Source:Zhonghua Yan Ke Za Zhi;53(6):436-439, 2017 Jun 11.
[Is] ISSN:0412-4081
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To conclude the characteristics of fundus appearance and spectral domain optical coherence tomography(SD-OCT) findings of patients with acute Vogt-Koyanagi-Harada (VKH) disease. The clinical data of 17 patients (34 eyes) diagnosed of acute VKH in Peking Union Medical College Hospital from Jan. 2012 to Dec. 2014 were studied retrospectively.Examinations included visual acuity, slit lamp, fundus, color fundus pictures, FFA and SD-OCT. Eight men and 9 women were enrolled with mean age of (40.5±11.6) years old ranging from 26.0 to 62.0 years old. Vision acuity of their first consultations were as follows: 14 eyes (41.2%) were below 0.01-0.09, 17 eyes(50%) were among 0.1-0.3, 3 eyes (8.8%) were among 0.4-0.7. All patients were divided into 3 groups according to their fundus appearance: 14 eyes (41.2%) were optic disc swelling-type, 10 eyes (29.4%) were retinal detachment type and 10 eyes(29.4%)were mixed type. Subretinal fluid and serous retinal detachment appears in SD-OCT of all 34 eyes, with highly reflective signals in detached area. Other common characters were also noticeable, suh as RPE folds(19 eyes, 55.9%), subretinal septa (16 eyes, 47.1%) and internal limiting membrane(ILM) fluctuation (8 eyes, 23.5%). In addition, SD-OCT features were in accordance with multilobular dye pooling at late period of FFA. SD-OCT of acute VKH presents some typical features: subretinal fluid and serous retinal detachment, RPE folds, ILM fluctuation, and subretinal septa. .
[Mh] Termos MeSH primário: Fundo de Olho
Tomografia de Coerência Óptica
Síndrome Uveomeningoencefálica/diagnóstico por imagem
[Mh] Termos MeSH secundário: Doença Aguda
Adulto
Feminino
Angiofluoresceinografia
Seres Humanos
Masculino
Meia-Idade
Papiledema/diagnóstico por imagem
Retina/diagnóstico por imagem
Descolamento Retiniano/diagnóstico por imagem
Estudos Retrospectivos
Microscopia com Lâmpada de Fenda
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0412-4081.2017.06.008


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[PMID]:28549088
[Au] Autor:Gampa A; Vangipuram G; Shirazi Z; Moss HE
[Ad] Endereço:Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States.
[Ti] Título:Quantitative Association Between Peripapillary Bruch's Membrane Shape and Intracranial Pressure.
[So] Source:Invest Ophthalmol Vis Sci;58(5):2739-2745, 2017 May 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to determine if there is a quantitative relationship between chronic intracranial pressure (ICP) and peripapillary Bruch's membrane (pp-BM) shape and to determine whether change in pp-BM shape can be detected within 1 hour after ICP lowering by lumbar puncture (LP). Methods: In this study, 30° nasal-temporal optical coherence tomography B-scans were obtained within 1 hour before and after LP in 39 eyes from 20 patients (age = 23-86 years, 75% female, ICP [opening pressure] = 10-55 cm H2O). A total of 16 semi-landmarks defined pp-BM on each image. Geometric morphometric analysis identified principal components of shape in the image set. Generalized estimating equation models, accounting for within-subject correlation, were used to identify principal components that were associated with chronic ICP (comparing pre-LP images between eyes) and/or acute ICP changes (comparing pre- and post-LP images within eyes). The pp-BM width and anterior pp-BM location were calculated directly from each image and were studied in the same manner. Results: Principal component 1 scalar variable on pre-LP images was associated with ICP (P < 0.0005). Principal component 4 magnitude changed within eyes after LP (P = 0.003). For both principal components 1 and 4, lower ICP corresponded with a more posterior position of pp-BM. Chronic ICP was associated with both pp-BM width (6.81 µm/cm H2O; P = 0.002) and more anterior location of temporal and nasal pp-BM margins (3.41, 3.49 µm/cm H2O; P < 0.0005, 0.002). Conclusions: This study demonstrates a quantitative association between pp-BM shape and chronic ICP level. Changes in pp-BM shape are detectable within 1 hour of lowering ICP. pp-BM shape may be a useful marker for chronic ICP level and acute ICP changes. Further study is needed to determine how pp-BM shape changes relate to clinical markers of papilledema.
[Mh] Termos MeSH primário: Lâmina Basilar da Corioide/patologia
Hipertensão Intracraniana/fisiopatologia
Pressão Intracraniana/fisiologia
Papiledema/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Hipertensão Intracraniana/cirurgia
Masculino
Meia-Idade
Disco Óptico/patologia
Papiledema/cirurgia
Punção Espinal
Tomografia de Coerência Óptica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-21592


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[PMID]:28533846
[Au] Autor:Bakayoko S; Guirou N; Coulibaly B; Traoré J
[Ad] Endereço:Centre Hospitalier Universitaire, Institut d'Ophtalmologie Tropicale d'Afrique, Boulevard du Peuple, Bamako, Mali, Boulevard du Peuple, Bamako, Mali.
[Ti] Título:[Bilateral papilledema secondary to intracranial hypertension in an adolescent girl].
[Ti] Título:Å’dème papillaire bilatéral secondaire à une hypertension intracrânienne chez une adolescente..
[So] Source:Pan Afr Med J;26:123, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Papilledema is a fluid and/or axonal swelling of the optic nerve head due to a blockage of axoplasmic flow at the level of the cribriform plate. We report the case of a 17-year old adolescent girl with bilateral papilledema secondary to idiopathic intracranial hypertension.
[Mh] Termos MeSH primário: Disco Óptico/patologia
Papiledema/etiologia
Pseudotumor Cerebral/complicações
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.26.123.11463


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[PMID]:28431433
[Au] Autor:Sun MH; Shariati MA; Liao YJ
[Ad] Endereço:Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, United States 2Department of Ophthalmology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
[Ti] Título:Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation.
[So] Source:Invest Ophthalmol Vis Sci;58(4):2296-2305, 2017 Apr 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Diabetes mellitus (DM) is one of the most important risk factors for nonarteritic anterior ischemic optic neuropathy (AION). In this study, we investigated for the first time the impact of experimental AION in a DM model. Methods: We induced a photochemical thrombosis model of AION after streptozotocin-induced DM and performed serial optical coherence tomography (OCT), morphometric analyses, and VEGF levels in the retina and sera. Results: Compared with non-DM animals, experimental AION in DM mice led to significantly greater retinal swelling on day 1 and worse thinning at week 3 on OCT measurements. Greater retinal swelling on OCT in DM-AION eyes was associated with significantly increased loss of brain-specific homeobox/POU domain protein 3A (Brn3A+) retinal ganglion cells at week 3. In acute AION, there was greater inflammation as seen by an increase in ionized calcium-binding adapter molecule 1 (Iba1+)-activated microglia. On day 1, there was increase in vascular endothelial growth factor (VEGF) level in nondiabetic AION retinae and sera, but the VEGF level was the highest in the diabetic AION group, which decreased to nondiabetic levels after insulin treatment. The decrease in retinal and serum VEGF levels after insulin treatment correlated with a reduction in retinal swelling. Conclusions: In the setting of hyperglycemia, AION led to greater acute, postischemic microglial activation and elevation of VEGF levels, which likely contributed to greater retinal swelling acutely and worse retinal thinning and loss of retinal ganglion cells chronically. Treatment of hyperglycemia with insulin reduced VEGF levels and retinal swelling, consistent with the idea that VEGF is an important factor in postischemic swelling and that good glycemic control following AION may lead to better visual outcome.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/complicações
Disco Óptico/patologia
Neuropatia Óptica Isquêmica/etiologia
Papiledema/etiologia
Retina/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
Acuidade Visual
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Diabetes Mellitus Experimental/metabolismo
Camundongos Endogâmicos C57BL
Disco Óptico/irrigação sanguínea
Neuropatia Óptica Isquêmica/diagnóstico
Neuropatia Óptica Isquêmica/metabolismo
Papiledema/diagnóstico
Papiledema/metabolismo
Retina/patologia
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-20308


  10 / 3711 MEDLINE  
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[PMID]:28391369
[Au] Autor:García-Montesinos J; Muñoz-Negrete FJ; de Juan V; Rebolleda G
[Ad] Endereço:Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Carretera de Colmenar Viejo, km. 9.100, 28034, Madrid, Spain. jmontesinos86@hotmail.com.
[Ti] Título:Relationship between lamina cribrosa displacement and trans-laminar pressure difference in papilledema.
[So] Source:Graefes Arch Clin Exp Ophthalmol;255(6):1237-1243, 2017 Jun.
[Is] ISSN:1435-702X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to describe morphological changes in lamina cribrosa (LC), prelaminar tissue thickness (PTT) and Bruch's membrane opening (BMO) in eyes affected by papilledema and correlate them with trans-LC-pressure difference (TLCD). METHODS: This was a prospective study, including twelve eyes newly diagnosed of papilledema. Eyes underwent scanning with Spectralis-OCT with enhanced depth imaging to compare BMO, anterior LC surface position (LC depth-LCD-) and PTT before and after oedema resolution. Correlation analysis between these parameters and TLCD was performed. RESULTS: TLCD inversely correlated with LCD at baseline and directly with LC reversal movement after lowering cerebrospinal fluid pressure (CSFP) (ρ -0.739, p = 0.006; ρ 0.844, p = 0.001 respectively). At onset, RNFL thickening and BMO were significantly larger in eyes with TLCD > -9.2 mmHg (group 2) compared with TLCD < -9.2 mmHg (group 1) [p = 0.007, p = 0.041 respectively]. A significant RNFL and BMO shrinking were observed, but they were significantly larger in group 2. The magnitude of LC displacement following oedema resolution was significantly larger and in the opposite direction in group 2 vs group 1 (-68.7 µm vs 19.5 µm, p = 0.016). TLCD correlated with RNFL thickening at baseline (ρ 0.667, p = 0.018) and with RNFL thinning at last visit (ρ 0.673, p = 0.017). TLCD correlated with mean deviation (MD) (ρ 0.712, p = 0.014) and visual field index (VFI) (ρ -0.657, p = 0.028) at onset. MD and VFI were worse in group 2. CONCLUSIONS: LC position was significantly related to TLCD in papilledema. Eyes with higher TCLD showed significantly larger backward LC movement, BMO shrinking and RNFL thinning after lowering CSFP compared with eyes with lower TLCD, where LC movement occurred in the opposite direction.
[Mh] Termos MeSH primário: Lâmina Basilar da Corioide/patologia
Pressão Intraocular
Disco Óptico/patologia
Papiledema/fisiopatologia
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica/métodos
Campos Visuais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Fibras Nervosas/patologia
Papiledema/diagnóstico
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE
[do] DOI:10.1007/s00417-017-3661-6



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