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Pesquisa : C10.597.404 [Categoria DeCS]
Referências encontradas : 5265 [refinar]
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[PMID]:28456003
[Au] Autor:Röhr D; Halfter H; Schulz JB; Young P; Gess B
[Ad] Endereço:Department of Sleep Medicine and Neuromuscular Disorders, University Hospital Muenster, Muenster, Germany.
[Ti] Título:Sodium-dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation.
[So] Source:Glia;65(7):1186-1200, 2017 Jul.
[Is] ISSN:1098-1136
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peripheral nerve myelination involves rapid production of tightly bound lipid layers requiring cholesterol biosynthesis and myelin protein expression, but also a collagen-containing extracellular matrix providing mechanical stability. In previous studies, we showed a function of ascorbic acid in peripheral nerve myelination and extracellular matrix formation in adult mice. Here, we sought the mechanism of action of ascorbic acid in peripheral nerve myelination using different paradigms of myelination in vivo and in vitro. We found impaired myelination and reduced collagen expression in Sodium-dependent Vitamin C Transporter 2 heterozygous mice (SVCT2 ) during peripheral nerve development and after peripheral nerve injury. In dorsal root ganglion (DRG) explant cultures, hypo-myelination could be rescued by precoating with different collagen types. The activity of the ascorbic acid-dependent demethylating Ten-eleven-translocation (Tet) enzymes was reduced in ascorbic acid deprived and SVCT2 DRG cultures. Further, in ascorbic acid-deprived DRG cultures, methylation of a CpG island in the collagen alpha1 (IV) and alpha2 (IV) bidirectional promoter region was increased compared to wild-type and ascorbic acid treated controls. Taken together, these results provide further evidence for the function of ascorbic acid in myelination and extracellular matrix formation in peripheral nerves and suggest a putative molecular mechanism of ascorbic acid function in Tet-dependent demethylation of collagen promoters.
[Mh] Termos MeSH primário: Colágeno/metabolismo
Desmetilação
Traumatismos dos Nervos Periféricos/genética
Traumatismos dos Nervos Periféricos/fisiopatologia
Remielinização/genética
Transportadores de Sódio Acoplados à Vitamina C/deficiência
[Mh] Termos MeSH secundário: Animais
Ácido Ascórbico/farmacologia
Células Cultivadas
Colágeno/genética
Modelos Animais de Doenças
Feminino
Transtornos Neurológicos da Marcha/etiologia
Gânglios Espinais/citologia
Masculino
Camundongos
Camundongos Transgênicos
Nervos Periféricos/patologia
Nervos Periféricos/ultraestrutura
RNA Mensageiro/metabolismo
Teste de Desempenho do Rota-Rod
Células Receptoras Sensoriais/metabolismo
Células Receptoras Sensoriais/patologia
Transportadores de Sódio Acoplados à Vitamina C/genética
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Slc23a2 protein, mouse); 0 (Sodium-Coupled Vitamin C Transporters); 9007-34-5 (Collagen); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1002/glia.23152


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[PMID]:29390312
[Au] Autor:Jang SH; Lee HD
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
[Ti] Título:Gait recovery by activation of the unaffected corticoreticulospinal tract in a stroke patient: A case report.
[So] Source:Medicine (Baltimore);96(50):e9123, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A 50-year-old man presented with complete paralysis at the onset of a putaminal hemorrhage. PATIENT CONCERNS: The patient presented with complete paralysis of the left upper and lower extremities (Medical Research Council:0/5). DIAGNOSES: Spontaneous intra crebral hemorrhage on putamen. INTERVENTION: He underwent comprehensive rehabilitative therapy from 3 weeks after onset. At 3weeks after onset, he presented with severe weakness of the left extremities. The weakness of his left extremities had recovered as follows at 3 months after onset. Consequently, he was able to walk independently on an even floor. OUTCOMES: On 3-week and 3-month diffusion tensor tractography (DTTs), the right corticospinal tract (CST) and the corticoreticulospinal tract (CRT) showed discontinuations below the lesion. On 3-month DTT, the left CST had become thinner; however, the left CRT had become thicker compared with 3-week DTT (Fig. 1). LESSONS: To the best of our knowledge, this is the first study to demonstrate the activation process of the CRT in the unaffected hemisphere in relation to gait recovery from early to chronic stage of stroke.
[Mh] Termos MeSH primário: Transtornos Neurológicos da Marcha/reabilitação
Paralisia/reabilitação
Hemorragia Putaminal/complicações
[Mh] Termos MeSH secundário: Imagem de Tensor de Difusão
Transtornos Neurológicos da Marcha/etiologia
Seres Humanos
Masculino
Meia-Idade
Paralisia/etiologia
Recuperação de Função Fisiológica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009123


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[PMID]:29220673
[Au] Autor:Martin S; Chamberlin A; Shinde DN; Hempel M; Strom TM; Schreiber A; Johannsen J; Ousager LB; Larsen MJ; Hansen LK; Fatemi A; Cohen JS; Lemke J; Sørensen KP; Helbig KL; Lessel D; Abou Jamra R
[Ad] Endereço:Institute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.
[Ti] Título:De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.
[So] Source:Am J Hum Genet;101(6):1013-1020, 2017 Dec 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using trio whole-exome sequencing, we have identified de novo heterozygous pathogenic variants in GRIA4 in five unrelated individuals with intellectual disability and other symptoms. GRIA4 encodes an AMPA receptor subunit known as GluR4, which is found on excitatory glutamatergic synapses and is important for learning and memory. Four of the variants are located in the highly conserved SYTANLAAF motif in the transmembrane protein M3, and the fifth is in an extra-cellular domain. Molecular modeling of the altered protein showed that three of the variants in the SYTANLAAF motif orient toward the center of the pore region and most likely lead to disturbance of the gating mechanism. The fourth variant in the SYTANLAAF motif most likely results in reduced permeability. The variant in the extracellular domain potentially interferes with the binding between the monomers. On the basis of clinical information and genetic results, and the fact that other subunits of the AMPA receptor have already been associated with neurodevelopmental disorders, we suggest that pathogenic de novo variants in GRIA4 lead to intellectual disability with or without seizures, gait abnormalities, problems of social behavior, and other variable features.
[Mh] Termos MeSH primário: Transtornos Neurológicos da Marcha/genética
Deficiência Intelectual/genética
Transtornos dos Movimentos/genética
Receptores de AMPA/genética
Convulsões/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Pré-Escolar
Feminino
Seres Humanos
Masculino
Modelos Moleculares
Comportamento Problema
Comportamento Social
Sequenciamento Completo do Exoma
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, AMPA); 0 (glutamate receptor ionotropic, AMPA 4)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


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[PMID]:29226660
[Au] Autor:Nakashima Y; Okazak K; Nakayama K; Okada S; Mizu-uchi H
[Ti] Título:Bone and Joint Diseases in Present and Future.
[So] Source:Fukuoka Igaku Zasshi;108(1):1-7, 2017 01.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:With the increase of elderly population, orthopaedic surgeons need to deal with the diseases related to aging, such as joint disorders and fragility fractures. The number of total joint replacements, for example, is two times more than it was 10 years ago. With these backgrounds, the Japanese Orthopaedic Association (JOA) has proposed the concept of locomotive syndrome; conditions under which the elderly have been receiving care services due to problems of the locomotive organs. To prevent geriatric or disuse syndrome, JOA is currently providing the care‒prevention programs such as the loco-check and loco-training. Recent advances in the orthopaedic fields were cited in this review article, including the topics of new biomaterials, regenerative medicine of cartilage, spinal cord injury and computer assisted orthopaedic surgery. These new technologies and knowledge are changing or have potential to change the future orthopedic medical care.
[Mh] Termos MeSH primário: Doenças Ósseas/cirurgia
Artropatias/cirurgia
[Mh] Termos MeSH secundário: Doenças Ósseas/complicações
Transtornos Neurológicos da Marcha/complicações
Seres Humanos
Artropatias/complicações
Próteses e Implantes
Regeneração
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; ENGLISH ABSTRACT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28448898
[Au] Autor:Eek MN; Zügner R; Stefansdottir I; Tranberg R
[Ad] Endereço:Regional Rehabilitation Centre, Queen Silvia Children's Hospital, Box 21062, SE-418 04 Gothenburg, Sweden. Electronic address: meta.nystrom-eek@vgregion.se.
[Ti] Título:Kinematic gait pattern in children with cerebral palsy and leg length discrepancy: Effects of an extra sole.
[So] Source:Gait Posture;55:150-156, 2017 Jun.
[Is] ISSN:1879-2219
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The gait pattern in children with cerebral palsy (CP) often differs from normal, with slow velocity, problem with foot clearance and increased stress on joints. Several factors, such as muscle tone, impaired motor control, muscle contractures, skeletal deformities and leg length discrepancy affect gait. Leg length discrepancy can be treated surgically or with elevation of the shoe on the short leg. The purpose of this study was to examine whether compensating for leg length discrepancy, with elevation of the sole, leads to a change in movement pattern during walking in children with spastic CP. RESULTS: Ten children with spastic CP, able to walk without aids, and 10 typically developing (TD) children aged between seven and 14 years were assessed with 3D gait analysis: 1) barefoot, 2) with shoes and 3) with an extra sole beneath the shoe for the shorter leg. All children with CP had a leg length discrepancy of more than or equal to 1.0cm. In the barefoot condition, the velocity was slower and the stride length was shorter, in children with CP compared with TD. The stride length and gait velocity increased in children with CP with shoes and shoe+sole and the stance time became more symmetrical. Among children with CP, there was more flexion in the longer leg relative to the short leg during barefoot walking. Differences in the kinematic pattern between the long and the short leg decreased with the extra sole.
[Mh] Termos MeSH primário: Paralisia Cerebral/fisiopatologia
Órtoses do Pé
Transtornos Neurológicos da Marcha/fisiopatologia
Desigualdade de Membros Inferiores/fisiopatologia
Desigualdade de Membros Inferiores/reabilitação
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:29205220
[Au] Autor:Ogrodnik J; Piszczatowski S
[Ad] Endereço:Department of Biocybernetics and Biomedical Engineering, Faculty of Mechanical Engineering, Bialystok University of Technology, Bialystok, Poland.
[Ti] Título:Influence of modified muscle morphology and activity pattern on the results of musculoskeletal system modelling in cerebral palsy patient.
[So] Source:Acta Bioeng Biomech;19(3):63-75, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of the present study was to evaluate the influence of modified morphological parameters of the muscle model and excitation pattern on the results of musculoskeletal system numerical simulation in a cerebral palsy patient. METHODS: The modelling of the musculoskeletal system was performed in the AnyBody Modelling System. The standard model (MoCap) was subjected to modifications consisting of changes in morphological parameters and excitation patterns of selected muscles. The research was conducted with the use of data of a 14-year-old cerebral palsy patient. RESULTS: A reduction of morphological parameters (variant MI) caused a decrease in the value of active force generated by the muscle with changed geometry, and as a consequence the changes in active force generated by other muscles. A simulation of the abnormal excitation pattern (variant MII) resulted in the muscle's additional activity during its lengthening. The simultaneous modification of the muscle morphology and excitation pattern (variant MIII) points to the interdependence of both types of muscle model changes. A significant increase in the value of the reaction force in the hip joint was observed as a consequence of modification of the hip abductor activity. CONCLUSIONS: The morphological parameters and the excitation pattern of modelled muscles have a significant influence on the results of numerical simulation of the musculoskeletal system functioning.
[Mh] Termos MeSH primário: Paralisia Cerebral/patologia
Paralisia Cerebral/fisiopatologia
Transtornos Neurológicos da Marcha/fisiopatologia
Modelos Biológicos
Contração Muscular
Músculo Esquelético/patologia
Músculo Esquelético/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Simulação por Computador
Feminino
Transtornos Neurológicos da Marcha/patologia
Articulação do Quadril/fisiopatologia
Seres Humanos
Força Muscular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:29205208
[Au] Autor:Guzik A; Druzbicki M; Przysada G; Kwolek A; Brzozowska-Magon A; Sobolewski M
[Ad] Endereço:Institute of Physiotherapy, University of Rzeszów, Rzeszów, Poland.
[Ti] Título:Relationships between walking velocity and distance and the symmetry of temporospatial parameters in chronic post-stroke subjects.
[So] Source:Acta Bioeng Biomech;19(3):147-154, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Subjects with post-stroke hemiparesis frequently present with asymmetric gait patterns. Symmetry, reflecting similarities in temporospatial, kinematic parameters, is an important measure of gait assessment. The study was designed to examine the relationships between asymmetry of temporal, spatial and kinematic gait parameters and walking velocity and distance. METHODS: Temporospatial and kinematic gait parameters were examined in a group of 50 chronic post-stroke subjects and in a group of 25 healthy controls. Symmetry ratio was calculated for all the parameters. Gait velocity was measured during 10-metre test, the walking distance during 2-Minute Walk Test, and balance during Up and Go Test. RESULTS: The relationship between stance phase duration symmetry and gait speed was at a moderate level (r = -0.43, p = 0.0173). There was a moderate relationship between swing phase symmetry and walking velocity and distance. The findings did not show a significant correlation between step length symmetry versus gait speed and distance. CONCLUSIONS: There is a mild relationship between self-selected gait velocity and walking distance versus temporal parameters symmetry. The findings do not confirm a relationship between self-selected gait velocity and walking distance versus spatial and kinematic parameters as well as balance. Likewise, no evidence confirms that asymmetry of temporal, spatial, kinematic gait parameters changes with the age of post-stroke subjects or is related to the length of time from stroke onset. Given the above, gait symmetry may be recognized as an important indicator of the level of gait control in post-stroke patients because it enables unique gait assessment, independent from other parameters.
[Mh] Termos MeSH primário: Lateralidade Funcional
Transtornos Neurológicos da Marcha/fisiopatologia
Paresia/fisiopatologia
Esforço Físico
Acidente Vascular Cerebral/fisiopatologia
Velocidade de Caminhada
[Mh] Termos MeSH secundário: Doença Crônica
Simulação por Computador
Feminino
Transtornos Neurológicos da Marcha/etiologia
Seres Humanos
Perna (Membro)/fisiopatologia
Masculino
Meia-Idade
Modelos Biológicos
Paresia/etiologia
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Análise Espaço-Temporal
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


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[PMID]:27776271
[Au] Autor:Morel E; Allali G; Laidet M; Assal F; Lalive PH; Armand S
[Ad] Endereço:Willy Taillard Laboratory of Kinesiology, University Geneva Hospitals and Geneva University, Geneva, Switzerland.
[Ti] Título:Gait Profile Score in multiple sclerosis patients with low disability.
[So] Source:Gait Posture;51:169-173, 2017 01.
[Is] ISSN:1879-2219
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gait abnormalities are subtle in multiple sclerosis (MS) patients with low disability and need to be better determined. As a biomechanical approach, the Gait Profile Score (GPS) is used to assess gait quality by combining nine gait kinematic variables in one single value. This study aims i) to establish if the GPS can detect gait impairments and ii) to compare GPS with discrete spatiotemporal and kinematic parameters in low-disabled MS patients. METHOD: Thirty-four relapsing-remitting MS patients with an Expanded Disability Status Scale (EDSS) score ≤2 (mean age 36.32±8.72 years; 12 men, 22 women; mean EDSS 1.19±0.8) and twenty-two healthy controls (mean age 36.85±7.87 years; 6 men, 16 women) matched for age, weight, height, body mass index and gender underwent an instrumented gait analysis. RESULTS: No significant difference in GPS values and in spatiotemporal parameters was found between patients and controls. However patients showed a significant alteration at the ankle and pelvis level. CONCLUSION: GPS fails to identify gait abnormalities in low-disabled MS patients, although kinematic analysis revealed subtle gait alterations. Future studies should investigate other methods to assess gait impairments with a gait score in low-disabled MS patients.
[Mh] Termos MeSH primário: Avaliação da Deficiência
Transtornos Neurológicos da Marcha/fisiopatologia
Marcha
Esclerose Múltipla Recidivante-Remitente/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Valor Preditivo dos Testes
Índice de Gravidade de Doença
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:27770681
[Au] Autor:Tangen GG; Bergland A; Engedal K; Mengshoel AM
[Ad] Endereço:Department of Health Sciences, University of Oslo, Pb 1089 Blindern, 0317 Oslo, Norway; Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Pb 2136, 3103 Tønsberg, Norway; Department of Geriatric Medicine, Oslo University Hospital, Pb 4956 Nydalen, 0424 Oslo, Norway. Elec
[Ti] Título:The importance of parkinsonian signs for gait and balance in patients with Alzheimer's disease of mild degree.
[So] Source:Gait Posture;51:159-161, 2017 01.
[Is] ISSN:1879-2219
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Parkinsonian signs are common in patients with Alzheimer's disease (AD) of mild degree and predict functional decline, but their relationship with gait speed and balance is unclear. The aims of this study were to describe characteristics of patients with parkinsonian signs among 98 patients with AD of mild degree (with no comorbid Parkinson's disease), and to examine associations between parkinsonian signs with gait speed and balance. A cross sectional study at a memory clinic was conducted. Presence of each parkinsonian sign (bradykinesia, rigidity and tremor) was derived from the UPDRS, regular gait speed was recorded over 10m and balance were assessed using the Mini-Balance Evaluation Systems Test (Mini-BESTest). Bradykinesia was present in 30.6% of the sample, rigidity in 13.3% and tremor only in one patient. Patients with bradykinesia were older, had worse cognitive impairment and worse gait and balance performance than those without bradykinesia. More men than women had rigidity. Bradykinesia was significantly associated with mini-BESTest after adjusting for demographic factors (p<0.001, explaining 13.3% of the variance), but was not significantly associated with gait speed. Rigidity was not associated with either gait speed or balance. We conclude that assessment of bradykinesia should be included in examination of balance control in patients with AD of mild degree.
[Mh] Termos MeSH primário: Doença de Alzheimer/fisiopatologia
Transtornos Neurológicos da Marcha/fisiopatologia
Marcha
Hipocinesia/fisiopatologia
Doença de Parkinson/fisiopatologia
Equilíbrio Postural
[Mh] Termos MeSH secundário: Idoso
Doença de Alzheimer/complicações
Estudos Transversais
Feminino
Transtornos Neurológicos da Marcha/complicações
Seres Humanos
Hipocinesia/complicações
Masculino
Doença de Parkinson/complicações
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29281574
[Au] Autor:AbdelRazek MA; Venna N
[Ad] Endereço:Harvard University, Cambridge, MA razek2@hotmail.com.
[Ti] Título:Ventriculoperitoneal-Shunt Placement for Normal-Pressure Hydrocephalus.
[So] Source:N Engl J Med;377(26):e35, 2017 12 28.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hidrocefalia de Pressão Normal/cirurgia
Derivação Ventriculoperitoneal
[Mh] Termos MeSH secundário: Idoso
Encéfalo/diagnóstico por imagem
Feminino
Transtornos Neurológicos da Marcha/etiologia
Seres Humanos
Hidrocefalia de Pressão Normal/complicações
Hidrocefalia de Pressão Normal/diagnóstico por imagem
Imagem por Ressonância Magnética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1701226



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