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[PMID]: 27464739 [Au] Autor: Grundmann F [Ad] Endereço: Klinik II für Innere Medizin, Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Kerpenerstr. 62, 50937, Köln, Deutschland. franziska.grundmann@uk-koeln.de. [Ti] Título: [Electrolyte disturbances in geriatric patients with focus on hyponatremia]. [Ti] Título: Elektrolytveränderungen im Alter mit Fokus auf Hyponatriämie.. [So] Source: Z Gerontol Geriatr;49(6):477-82, 2016 Aug. [Is] ISSN: 1435-1269 [Cp] País de publicação: Germany [La] Idioma: ger [Ab] Resumo: Disturbances of water and electrolyte balance are commonly encountered in older patients due to a multitude of physiological changes and preexisting morbidities with hyponatremia being the most common disorder. Even mild chronic hyponatremia can lead to cognitive deficits and gait instability and is associated with an increased rate of falls and fractures. Additionally, experimental and epidemiological data suggest that hyponatremia promotes bone resorption and therefore increases the risk of osteoporosis. Furthermore, osteoporosis and sarcopenia can be stimulated by hypomagnesemia. Hypernatremia often only results in unspecific symptoms but the condition is associated with a clearly increased mortality. As electrolyte disturbances have a high prevalence in the geriatric population and can contribute to geriatric syndromes and frailty, relevant electrolyte alterations should be excluded in all geriatric patients, in particular after a change in medication schedules. [Mh] Termos MeSH primário: Transtornos Cognitivos/mortalidade Apraxia da Marcha/mortalidade Hiponatremia/mortalidade Osteoporose/mortalidade Insuficiência Renal Crônica/mortalidade Sarcopenia/mortalidade [Mh] Termos MeSH secundário: Distribuição por Idade Idoso Idoso de 80 Anos ou mais Causalidade Transtornos Cognitivos/diagnóstico Transtornos Cognitivos/terapia Comorbidade Medicina Baseada em Evidências Feminino Apraxia da Marcha/diagnóstico Apraxia da Marcha/terapia Alemanha Seres Humanos Hiponatremia/diagnóstico Hiponatremia/terapia Masculino Osteoporose/diagnóstico Osteoporose/terapia Prevalência Insuficiência Renal Crônica/diagnóstico Insuficiência Renal Crônica/terapia Fatores de Risco Sarcopenia/diagnóstico Sarcopenia/terapia Taxa de Sobrevida Desequilíbrio Hidroeletrolítico/diagnóstico Desequilíbrio Hidroeletrolítico/mortalidade [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160729 [St] Status: MEDLINE [do] DOI: 10.1007/s00391-016-1117-y

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[PMID]: 27332069 [Au] Autor: Pereira FV; Oliveira FF; Schultz RR; Bertolucci PH [Ad] Endereço: Universidade Federal de São Paulo, Universidade Federal de São Paulo, São Paulo SP , Brasil, Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil. [Ti] Título: Balance impairment does not necessarily coexist with gait apraxia in mild and moderate Alzheimer's disease. [So] Source: Arq Neuropsiquiatr;74(6):450-5, 2016 Jun. [Is] ISSN: 1678-4227 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To assess correlations among gait apraxia, balance impairment and cognitive performance in mild (AD1, n = 30) and moderate (AD2, n = 30) AD. METHOD: The following evaluations were undertaken: gait apraxia (Assessment Walking Skills); balance performance (Berg Balance Scale); Clinical Dementia Rating and Mini-mental State Examination (MMSE). RESULTS: While disregarding AD subgroups, Berg Balance Scale and the MMSE correlated significantly with Assessment Walking Skills and 23% of all subjects scored below its cut-off. After stratification, Berg Balance Scale correlated significantly with Assessment Walking Skills in both AD subgroups, and with the MMSE only in AD1. CONCLUSIONS: Balance impairment does not necessarily coexist with gait apraxia. Gait apraxia is more prevalent in moderate AD when compared with mild AD. [Mh] Termos MeSH primário: Doença de Alzheimer/complicações Disfunção Cognitiva/etiologia Apraxia da Marcha/etiologia Equilíbrio Postural/fisiologia [Mh] Termos MeSH secundário: Idoso Doença de Alzheimer/fisiopatologia Disfunção Cognitiva/fisiopatologia Feminino Apraxia da Marcha/diagnóstico Apraxia da Marcha/fisiopatologia Avaliação Geriátrica Seres Humanos Masculino Testes Neuropsicológicos Índice de Gravidade de Doença [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160623 [St] Status: MEDLINE

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[PMID]: 27113598 [Au] Autor: Zhao Y; Nonnekes J; Storcken EJ; Janssen S; van Wegen EE; Bloem BR; Dorresteijn LD; van Vugt JP; Heida T; van Wezel RJ [Ad] Endereço: Biomedical Signal and Systems Group, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. 217, 7500, AE, Enschede, The Netherlands. yan.zhao@utwente.nl. [Ti] Título: Feasibility of external rhythmic cueing with the Google Glass for improving gait in people with Parkinson's disease. [So] Source: J Neurol;263(6):1156-65, 2016 Jun. [Is] ISSN: 1432-1459 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: New mobile technologies like smartglasses can deliver external cues that may improve gait in people with Parkinson's disease in their natural environment. However, the potential of these devices must first be assessed in controlled experiments. Therefore, we evaluated rhythmic visual and auditory cueing in a laboratory setting with a custom-made application for the Google Glass. Twelve participants (mean age = 66.8; mean disease duration = 13.6 years) were tested at end of dose. We compared several key gait parameters (walking speed, cadence, stride length, and stride length variability) and freezing of gait for three types of external cues (metronome, flashing light, and optic flow) and a control condition (no-cue). For all cueing conditions, the subjects completed several walking tasks of varying complexity. Seven inertial sensors attached to the feet, legs and pelvis captured motion data for gait analysis. Two experienced raters scored the presence and severity of freezing of gait using video recordings. User experience was evaluated through a semi-open interview. During cueing, a more stable gait pattern emerged, particularly on complicated walking courses; however, freezing of gait did not significantly decrease. The metronome was more effective than rhythmic visual cues and most preferred by the participants. Participants were overall positive about the usability of the Google Glass and willing to use it at home. Thus, smartglasses like the Google Glass could be used to provide personalized mobile cueing to support gait; however, in its current form, auditory cues seemed more effective than rhythmic visual cues. [Mh] Termos MeSH primário: Óculos Apraxia da Marcha/reabilitação Marcha Aplicativos Móveis Doença de Parkinson/reabilitação Equipamentos de Autoajuda [Mh] Termos MeSH secundário: Estimulação Acústica/métodos Idoso Fenômenos Biomecânicos Sinais (Psicologia) Estudos de Viabilidade Feminino Apraxia da Marcha/etiologia Apraxia da Marcha/fisiopatologia Seres Humanos Entrevistas como Assunto Masculino Meia-Idade Doença de Parkinson/complicações Doença de Parkinson/fisiopatologia Periodicidade Estimulação Luminosa/métodos Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170405 [Lr] Data última revisão: 170405 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160427 [St] Status: MEDLINE [do] DOI: 10.1007/s00415-016-8115-2

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[PMID]: 26930369 [Au] Autor: Anderson-Mooney AJ; Schmitt FA; Head E; Lott IT; Heilman KM [Ad] Endereço: University of Kentucky College of Medicine, Department of Neurology, 740 S. Limestone, Suite B-101, Lexington, KY 40536, United States. Electronic address: amelia.anderson@uky.edu. [Ti] Título: Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. [So] Source: Brain Cogn;104:48-57, 2016 Apr. [Is] ISSN: 1090-2147 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Down syndrome (DS) is the most common genetic cause of intellectual disability in children. With aging, DS is associated with an increased risk for Alzheimer's disease (AD). The development of AD neuropathology in individuals with DS can result in further disturbances in cognition and behavior and may significantly exacerbate caregiver burden. Early detection may allow for appropriate preparation by caregivers. Recent literature suggests that declines in gait may serve as an early marker of AD-related cognitive disorders; however, this relationship has not been examined in individuals with DS. The theory regarding gait dyspraxia and cognitive decline in the general population is reviewed, and potential applications to the population with individuals with DS are highlighted. Challenges and benefits in the line of inquiry are discussed. In particular, it appears that gait declines in aging individuals with DS may be associated with known declines in frontoparietal gray matter, development of AD-related pathology, and white matter losses in tracts critical to motor control. These changes are also potentially related to the cognitive and functional changes often observed during the same chronological period as gait declines in adults with DS. Gait declines may be an early marker of cognitive change, related to the development of underlying AD-related pathology, in individuals with DS. Future investigations in this area may provide insight into the clinical changes associated with development of AD pathology in both the population with DS and the general population, enhancing efforts for optimal patient and caregiver support and propelling investigations regarding safety/quality of life interventions and disease-modifying interventions. [Mh] Termos MeSH primário: Envelhecimento Doença de Alzheimer/fisiopatologia Transtornos Cognitivos/fisiopatologia Síndrome de Down/fisiopatologia Apraxia da Marcha/fisiopatologia [Mh] Termos MeSH secundário: Doença de Alzheimer/patologia Doença de Alzheimer/psicologia Cognição Transtornos Cognitivos/patologia Transtornos Cognitivos/psicologia Síndrome de Down/patologia Síndrome de Down/psicologia Apraxia da Marcha/patologia Seres Humanos Doenças do Sistema Nervoso Qualidade de Vida Risco Substância Branca/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW [Em] Mês de entrada: 1611 [Cu] Atualização por classe: 170403 [Lr] Data última revisão: 170403 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160302 [St] Status: MEDLINE

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[PMID]: 26886230 [Au] Autor: Rinaldi LA; Simoni D; Maresca M; Monaco V; Matucci-Cerinic M; Melchiorre D [Ad] Endereço: Unit of Gerontology and Geriatric Medicine, Department of Experimental and Clinical Medicine, University of Florence, Italy. [Ti] Título: Gait abnormalities in early rheumatoid arthritis with temporomandibular joint involvement. [So] Source: Clin Exp Rheumatol;34(3):561, 2016 May-Jun. [Is] ISSN: 0392-856X [Cp] País de publicação: Italy [La] Idioma: eng [Mh] Termos MeSH primário: Artrite Reumatoide Apraxia da Marcha Articulação Temporomandibular [Mh] Termos MeSH secundário: Adulto Artrite Reumatoide/complicações Artrite Reumatoide/diagnóstico Artrite Reumatoide/fisiopatologia Diagnóstico Precoce Intervenção Médica Precoce Feminino Apraxia da Marcha/diagnóstico Apraxia da Marcha/etiologia Seres Humanos Masculino Equilíbrio Postural Articulação Temporomandibular/diagnóstico por imagem Articulação Temporomandibular/patologia Ultrassonografia [Pt] Tipo de publicação: LETTER [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 170112 [Lr] Data última revisão: 170112 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160218 [St] Status: MEDLINE

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[PMID]: 26624899 [Au] Autor: Magnin E; Sagawa Y; Chamard L; Berger E; Moulin T; Decavel P [Ad] Endereço: Regional Memory Centre (CMRR), Department of Neurology, University Hospital of Besanx00E7;on, Besanx00E7;on, France. [Ti] Título: Verbal Fluencies and Fampridine Treatment in Multiple Sclerosis. [So] Source: Eur Neurol;74(5-6):243-50, 2015. [Is] ISSN: 1421-9913 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIMS: Fampridine is sometimes reported to improve cognition and especially the information-processing speed. Motor improvement might be a confounding factor. The aim of this study was to evaluate the effects of fampridine on verbal fluencies in patients with multiple sclerosis (MS). METHODS: Fifty MS patients were included in a prospective monocentric open label trial with a mean Expanded Disability Status Scale of 5.3 ± 1.1. Assessments of verbal phonological and semantic fluencies were repeated twice (within 1 week) before fampridine treatment and twice after fampridine treatment in order to have the maximal practice effect. Gait velocity and fatigue (visual analogical scale) were also assessed. Distribution into gait responders, gait non-responders, fluency responders and fluency non-responders, was described. RESULTS: Verbal fluencies were significantly higher after fampridine treatment. No correlation was observed between phonological fluency improvement and semantic fluency improvement. Gait responders and gait non-responders did not present significant differences in verbal fluency performance and fatigue score. No correlation between gait velocity improvement and fatigue improvement compared with verbal fluency improvement was observed. CONCLUSION: Our results suggest that fampridine could have a selective procognitive effect on phonological fluency in MS, even in the gait non-responder patients. [Mh] Termos MeSH primário: 4-Aminopiridina/uso terapêutico Transtornos Cognitivos/tratamento farmacológico Apraxia da Marcha/tratamento farmacológico Esclerose Múltipla/tratamento farmacológico Distúrbios da Fala/tratamento farmacológico Medida da Produção da Fala Comportamento Verbal/efeitos dos fármacos [Mh] Termos MeSH secundário: Adulto Avaliação da Deficiência Feminino França Seres Humanos Masculino Meia-Idade Estudos Prospectivos [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE [Nm] Nome de substância: BH3B64OKL9 (4-Aminopyridine) [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 160115 [Lr] Data última revisão: 160115 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151202 [St] Status: MEDLINE [do] DOI: 10.1159/000442348

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[PMID]: 26438353 [Au] Autor: Adorno A; Alafaci C; Sanfilippo F; Cafarella D; Scordino M; Granata F; Grasso G; Salpietro FM [Ad] Endereço: Department of Neurosurgery - AOOR Papardo-Piemonte, Contrada Papardo, 98158, Messina, Italy. aleadorno@yahoo.it. [Ti] Título: Malignant teratoma in Klippel-Feil syndrome: a case report and review of the literature. [So] Source: J Med Case Rep;9:229, 2015 Oct 04. [Is] ISSN: 1752-1947 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Klippel-Feil syndrome is characterized by a congenital fusion of cervical vertebrae. Intracranial teratomas are nongerminomatous germ cell tumors and they account for 0.3 to 0.9% of all intracranial tumors. Teratomas with malignant transformation refer to lesions which give rise to malignant cancer of somatic type. The association between tumors of dermoid origin and Klippel-Feil malformation is extremely rare. Only 23 other cases have so far been reported, and only one case of dermoid tumor with areas of dedifferentiation on squamous cell carcinoma has been described. CASE PRESENTATION: We report the case of a 72-year-old white man with a 2-year history of gait and balance disturbances. A brain magnetic resonance imaging revealed a fourth ventricle neoplastic process with infiltrative features. He was operated through a suboccipital craniectomy with a C1 laminotomy and bilateral vertebral artery transposition. At 6-months follow-up, magnetic resonance imaging showed an early regrowth of the fourth ventricle tumor, with the same radiological features. CONCLUSIONS: Patients with Klippel-Feil malformation could develop posterior fossa dermoid tumors. The malignant potential of such tumors must be considered and surgery is recommended. Particular attention must be focused on the histopathological analysis in order to identify possible foci of malignant transformation. [Mh] Termos MeSH primário: Vértebras Cervicais/patologia Fossa Craniana Posterior/patologia Síndrome de Klippel-Feil/diagnóstico Teratoma/diagnóstico [Mh] Termos MeSH secundário: Idoso Vértebras Cervicais/anormalidades Vértebras Cervicais/diagnóstico por imagem Fossa Craniana Posterior/anormalidades Fossa Craniana Posterior/diagnóstico por imagem Fossa Craniana Posterior/cirurgia Cisto Dermoide/patologia Apraxia da Marcha/etiologia Seres Humanos Síndrome de Klippel-Feil/complicações Síndrome de Klippel-Feil/diagnóstico por imagem Síndrome de Klippel-Feil/patologia Imagem por Ressonância Magnética Masculino Teratoma/diagnóstico por imagem Teratoma/patologia Teratoma/cirurgia Tomografia Computadorizada por Raios X Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151007 [St] Status: MEDLINE [do] DOI: 10.1186/s13256-015-0700-y

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[PMID]: 26355909 [Au] Autor: Avecillas-Chasín JM; Brin JR; Lopez-Ibor L; Gomez G; Rodriguez-Boto G [Ad] Endereço: Department of Neurosurgery, Institute of Neurological Sciences, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain. Electronic address: josue.avecillas@salud.madrid.org. [Ti] Título: Multiple spinal arteriovenous fistulas: A case-based review. [So] Source: Clin Neurol Neurosurg;139:6-11, 2015 Dec. [Is] ISSN: 1872-6968 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The occurrence of multiple spinal dural arteriovenous fistulas (AVFs) is rare. The majority of cases reported are synchronous and the lesions are mainly found at different spinal levels. Metachronous AVFs have been defined as lesions that manifest in a temporal sequence after treatment of a first AVF. In this report, we present two distinct cases of multiple spinal AVFs. Also, we review the main features of the cases previously reported, with emphasis on the proposed theories for the origin of multiple AVFs. In patients with failure to improve after treatment of a spinal DAVF, a whole-spine angiographic examination is mandatory, not only to ascertain the complete closure of the treated fistula, but also to look for a possible second lesion at a different spinal level. [Mh] Termos MeSH primário: Malformações Vasculares do Sistema Nervoso Central/diagnóstico Medula Espinal/patologia [Mh] Termos MeSH secundário: Idoso Angiografia Malformações Vasculares do Sistema Nervoso Central/complicações Malformações Vasculares do Sistema Nervoso Central/terapia Vértebras Cervicais Embolização Terapêutica Apraxia da Marcha/etiologia Seres Humanos Imagem por Ressonância Magnética Masculino Meia-Idade Parestesia/etiologia Medula Espinal/irrigação sanguínea Vértebras Torácicas Incontinência Urinária/etiologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1609 [Cu] Atualização por classe: 151128 [Lr] Data última revisão: 151128 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150911 [St] Status: MEDLINE

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[PMID]: 25378916 [Au] Autor: Stenhagen M; Ekström H; Nordell E; Elmståhl S [Ad] Endereço: Department of Health Sciences, Division of Geriatric Medicine, Lund University, Skåne University Hospital, Malmö, Sweden. [Ti] Título: Both deterioration and improvement in activities of daily living are related to falls: a 6-year follow-up of the general elderly population study Good Aging in Skåne. [So] Source: Clin Interv Aging;9:1839-46, 2014. [Is] ISSN: 1178-1998 [Cp] País de publicação: New Zealand [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To determine the relationship between long-term change in activities of daily living (ADL) and falls in the elderly and to identify characteristics of groups at risk for falls. METHODS: This was a 6-year, prospective cohort study using data from the Good Aging in Skåne study in southern Sweden, involving 1,540 elderly subjects, including the oldest-old (age, 60-93 years). The subjects were recruited from the general population. ADL was measured at a baseline and follow-up assessment, using Sonn and Åsberg's revised scale and the ADL staircase. Falls were recorded in a period of 6 months before the follow-up assessment. The association between falls and change in ADL was calculated using adjusted, multiple logistic regression analysis and presented in odds ratios (ORs). RESULTS: Thirteen percent of the study population reported one or several falls in the measured period. Over the course of 6 years, one in four participants changed their ADL status, and parts of this category had an increased risk for falls compared with those who stayed independent in ADL or who had no change in the ADL staircase. Groups with different characteristics had a prominent risk for falls: those with a reduction of two to eight steps in the ADL staircase (OR, 4.05; 95% confidence interval [CI], 1.62-10.11) and those becoming independent from dependency in instrumental ADL (OR, 4.13; 95% CI, 1.89-9.00). The former group had advanced age with a greater burden of cognitive impairment, gait disability, arrhythmia, and fall risk medications. The latter group had a higher prevalence of ischemic heart disease and low walking speed. CONCLUSION: Both deterioration and improvement in ADL over the course of 6 years increased the risk for falls in a general elderly population. Interventional efforts may require different strategies, as groups with different characteristics were at risk. Those at risk with improved ADL function may have a history of sufficient burden of comorbidity combined with obtained mobility for exposure to a fall event. [Mh] Termos MeSH primário: Acidentes por Quedas/estatística & dados numéricos Atividades Cotidianas/classificação [Mh] Termos MeSH secundário: Acidentes por Quedas/prevenção & controle Fatores Etários Idoso Idoso de 80 Anos ou mais Doença de Alzheimer/epidemiologia Arritmias Cardíacas/epidemiologia Estudos de Coortes Comorbidade Feminino Marcha Apraxia da Marcha/epidemiologia Seres Humanos Estudos Longitudinais Masculino Meia-Idade Isquemia Miocárdica/epidemiologia Estudos Prospectivos Fatores de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1504 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141108 [St] Status: MEDLINE [do] DOI: 10.2147/CIA.S70075

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[PMID]: 25336936 [Au] Autor: Kwon Y; Park SH; Kim JW; Ho Y; Jeon HM; Bang MJ; Jung GI; Lee SM; Eom GM; Koh SB; Lee JW; Jeon HS [Ad] Endereço: Biomedical Engineering, Konkuk University, Chungju, Korea. [Ti] Título: A practical method for the detection of freezing of gait in patients with Parkinson's disease. [So] Source: Clin Interv Aging;9:1709-19, 2014. [Is] ISSN: 1178-1998 [Cp] País de publicação: New Zealand [La] Idioma: eng [Ab] Resumo: PURPOSE: Freezing of gait (FOG), increasing the fall risk and limiting the quality of life, is common at the advanced stage of Parkinson's disease, typically in old ages. A simple and unobtrusive FOG detection system with a small calculation load would make a fast presentation of on-demand cueing possible. The purpose of this study was to find a practical FOG detection system. PATIENTS AND METHODS: A sole-mounted sensor system was developed for an unobtrusive measurement of acceleration during gait. Twenty patients with Parkinson's disease participated in this study. A simple and fast time-domain method for the FOG detection was suggested and compared with the conventional frequency-domain method. The parameters used in the FOG detection were optimized for each patient. RESULTS: The calculation load was 1,154 times less in the time-domain method than the conventional method, and the FOG detection performance was comparable between the two domains (P=0.79) and depended on the window length (P<0.01) and dimension of sensor information (P=0.03). CONCLUSION: A minimally constraining sole-mounted sensor system was developed, and the suggested time-domain method showed comparable FOG detection performance to that of the conventional frequency-domain method. Three-dimensional sensor information and 3-4-second window length were desirable. The suggested system is expected to have more practical clinical applications. [Mh] Termos MeSH primário: Aceleração Apraxia da Marcha/diagnóstico Doença de Parkinson/diagnóstico [Mh] Termos MeSH secundário: Acelerometria/instrumentação Acidentes por Quedas Idoso Idoso de 80 Anos ou mais Feminino Apraxia da Marcha/complicações Apraxia da Marcha/psicologia Seres Humanos Masculino Meia-Idade Doença de Parkinson/complicações Doença de Parkinson/psicologia Qualidade de Vida/psicologia Fatores de Risco Processamento de Sinais Assistido por Computador/instrumentação Suporte de Carga [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1504 [Cu] Atualização por classe: 151029 [Lr] Data última revisão: 151029 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 141023 [St] Status: MEDLINE [do] DOI: 10.2147/CIA.S69773

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