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[PMID]:29351316
[Au] Autor:Yeh CH; Hsieh LP; Lin MC; Wei TS; Lin HC; Chang CC; Hsing CH
[Ad] Endereço:Department of Medicinal Botanicals and Health applications, Da-Yeh University, Changhua, Taiwan.
[Ti] Título:Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia.
[So] Source:PLoS One;13(1):e0191070, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS: BALB/c mice were intraperitoneally (i.p.) injected with Dex (50 ug/kg) or vehicle. One hour later, the mice were injected (i.p.) with Escherichia coli LPS (0.33 mg/kg) or saline (n = 6 in each group). We analyzed the food and water intake, body weight loss, and sucrose preference of the mice for 24h. We also determined microglia activation and cytokines expression in the brains of the mice. In vitro, we determine cytokines expression in LPS-treated BV-2 microglial cells with or without Dex treatment. RESULTS: In the Dex-pretreated mice, LPS-induced sickness behavior (anorexia, weight loss, and social withdrawal) were attenuated and microglial activation was lower than vehicle control. The mRNA expression of TNF-α, MCP-1, indoleamine 2, 3 dioxygenase (IDO), caspase-3, and iNOS were increased in the brain of LPS-challenged mice, which were reduced by Dex but not vehicle. CONCLUSION: Dexmedetomidine diminished LPS-induced neuroinflammation in the mouse brain and modulated the cytokine-associated changes in sickness behavior.
[Mh] Termos MeSH primário: Anedonia/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Dexmedetomidina/farmacologia
Comportamento de Doença/efeitos dos fármacos
Inflamação/induzido quimicamente
Lipopolissacarídeos/toxicidade
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Encéfalo/patologia
Inflamação/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Microglia/efeitos dos fármacos
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipopolysaccharides); 67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191070


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[PMID]:28449907
[Au] Autor:Kalmbach DA; Arnedt JT; Swanson LM; Rapier JL; Ciesla JA
[Ad] Endereço:Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: dkalmbac@med.umich.edu.
[Ti] Título:Reciprocal dynamics between self-rated sleep and symptoms of depression and anxiety in young adult women: a 14-day diary study.
[So] Source:Sleep Med;33:6-12, 2017 May.
[Is] ISSN:1878-5506
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this study was to characterize the day-to-day associations among sleep disturbance, depression, and anxiety in a sample of young adult women. METHODS: One hundred and seventy-one women (20.1 ± 3.3 years) completed in-laboratory baseline assessment followed by daily online surveys across a two-week period. Daily measures included the Mood and Anxiety Symptom Questionnaire-Short Form to assess shared and disorder-specific symptoms of depression and anxiety (general distress, anhedonic depression, and anxious arousal), as well as self-reported total sleep time (TST), sleep-onset latency (SOL), and sleep quality (SQ). RESULTS: Findings supported bidirectional day-to-day relationships between sleep and affective symptoms. When women felt greater general distress (shared features of anxiety and depression), they experienced longer SOL and worse SQ at night. Specificity among depression, anxiety, and sleep disturbance was observed such that higher levels of depression-specific anhedonia presaged longer SOL, shorter TST, and poorer SQ. In the other direction, when women had poor-quality sleep, they later experienced greater anhedonic depression and anxious arousal. The influence of TST on anhedonia was complex such that a single night of short sleep led to less anhedonic depression the next day, whereas women who obtained shorter sleep across the two-week period reported greater anhedonia. CONCLUSIONS: Reciprocal dynamics between nightly sleep disturbance and daily experiences of depression and anxiety may serve as a process by which insomnia, depression, and anxiety develop into comorbid clinical states over time in women. The associations of anhedonic depression with nightly sleep disturbance and chronic short sleep were especially toxic, offering insight into daily mechanisms driving the most prevalent phenotype of comorbid insomnia.
[Mh] Termos MeSH primário: Ansiedade/complicações
Depressão/psicologia
Autorrelato
Transtornos do Sono-Vigília/fisiopatologia
Sono/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anedonia
Ansiedade/fisiopatologia
Depressão/complicações
Depressão/epidemiologia
Feminino
Seres Humanos
Distúrbios do Início e da Manutenção do Sono/complicações
Distúrbios do Início e da Manutenção do Sono/etiologia
Transtornos do Sono-Vigília/epidemiologia
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28460280
[Au] Autor:Da Silva S; Saperia S; Siddiqui I; Fervaha G; Agid O; Daskalakis ZJ; Ravindran A; Voineskos AN; Zakzanis KK; Remington G; Foussias G
[Ad] Endereço:Centre for Addiction and Mental Health, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada. Electronic address: susana.dasilva@camh.ca.
[Ti] Título:Investigating consummatory and anticipatory pleasure across motivation deficits in schizophrenia and healthy controls.
[So] Source:Psychiatry Res;254:112-117, 2017 Aug.
[Is] ISSN:1872-7123
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Anhedonia has traditionally been considered a characteristic feature of schizophrenia, but the true nature of this deficit remains elusive. This study sought to investigate consummatory and anticipatory pleasure as it relates to motivation deficits. Eighty-four outpatients with schizophrenia and 81 healthy controls were administered the Temporal Experience of Pleasure Scale (TEPS), as well as a battery of clinical and cognitive assessments. Multivariate analyses of variance were used to examine the experience of pleasure as a function of diagnosis, and across levels of motivation deficits (i.e. low vs. moderate. vs. high) in schizophrenia. Hierarchical regression analyses were also conducted to evaluate the predictive value of amotivation in relation to the TEPS. There were no significant differences between schizophrenia and healthy control groups for either consummatory or anticipatory pleasure. Within the schizophrenia patients, only those with high levels of amotivation were significantly impaired in consummatory and anticipatory pleasure compared to low and moderate groups, and compared to healthy controls. Further, our results revealed that amotivation significantly predicts both consummatory and anticipatory pleasure, with no independent contribution of group. Utilizing study samples with a wide range of motivation deficits and incorporating objective paradigms may provide a more comprehensive understanding of hedonic deficits.
[Mh] Termos MeSH primário: Antecipação Psicológica/fisiologia
Comportamento Consumatório/fisiologia
Motivação/fisiologia
Prazer/fisiologia
Esquizofrenia/fisiopatologia
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Adulto
Anedonia/fisiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Esquizofrenia/diagnóstico
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29179735
[Au] Autor:Foyet HS; Tchinda Deffo S; Koagne Yewo P; Antioch I; Zingue S; Asongalem EA; Kamtchouing P; Ciobica A
[Ad] Endereço:Department of Biological Sciences, Faculty of Science, University of Maroua, Cameroon, P.O. Box: 814, Maroua, Cameroon. fharquins@gmail.com.
[Ti] Título:Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats.
[So] Source:BMC Complement Altern Med;17(1):502, 2017 Nov 28.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stress, regardless of its nature is nowadays recognized as one of the major risk factors for neuropsychiatric diseases, such as mood and anxiety disorders. The brain compared with other organs is more vulnerable to oxidative damage mainly due to its high rate of oxygen consumption, abundant lipid content, and relative insufficiency of antioxidant enzymes. Thus, the identification of neural mechanisms underlying resistance and vulnerability to stress is of crucial importance in understanding the pathophysiology of neuropsychiatric disorders and in developing new treatments, since the existing ones are for several reasons subject to increasing limitations. This study was aimed to assess the effects of hydromethanolic extract of Ficus sycomorus stem bark on depression, anxiety and memory impairment induced by unpredictable chronic mild stress (UCMS) in rats. METHODS: These effects were studied using anxiety-related behavior, depression-related behavior, anhedonia-like behavior and the Y maze task. Sucrose test was performed twice (before and after UCMS) to assess anhedonia in rats. Liquid chromatography-mass spectrometry analysis of the extract were performed. The antioxidant activities of the extract were assessed using total glutathione (GSH) content and malondialdehyde (MDA) level (lipid peroxidation) in the rat temporal lobe homogenates. RESULTS: The extract of F. sycomorus in a dose of 100 mg/kg significantly increased the sucrose consumption and the swimming time which had been reduced by the unpredictable chronic mild stress (p < 0.001). The extract also significantly reduced (p < 0.01) the latency time in the novelty-suppressed feeding test. In the elevated plus-maze, the extract (100 and 200 mg/kg) significantly reduced (p < 0.01) the time and the number of entries into the closed arms. The treatment with the extracts also significantly increased alternation in the Y-maze (p < 0.01 for 100 mg/kg). The extract significantly increased the total GSH content and reduced MDA level in rat temporal lobe. For the LC-MS analysis, the major compound in the extract was a flavonoid with formula C H O . CONCLUSIONS: F. sycomorus reversed the harmful effects of UCMS on mood and behaviors in rats and it possesses an antidepressant property that is at least in part mediated through the oxidative pathway.
[Mh] Termos MeSH primário: Anedonia/efeitos dos fármacos
Comportamento Animal/efeitos dos fármacos
Química Encefálica/efeitos dos fármacos
Ficus/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Depressão
Modelos Animais de Doenças
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Ratos
Ratos Wistar
Estresse Psicológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2012-9


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[PMID]:29059254
[Au] Autor:Harlé KM; Guo D; Zhang S; Paulus MP; Yu AJ
[Ad] Endereço:Department of Psychiatry, UCSD, La Jolla, CA, United States of America.
[Ti] Título:Anhedonia and anxiety underlying depressive symptomatology have distinct effects on reward-based decision-making.
[So] Source:PLoS One;12(10):e0186473, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Depressive pathology, which includes both heightened negative affect (e.g., anxiety) and reduced positive affect (e.g., anhedonia), is known to be associated with sub-optimal decision-making, particularly in uncertain environments. Here, we use a computational approach to quantify and disambiguate how individual differences in these affective measures specifically relate to different aspects of learning and decision-making in reward-based choice behavior. Fifty-three individuals with a range of depressed mood completed a two-armed bandit task, in which they choose between two arms with fixed but unknown reward rates. The decision-making component, which chooses among options based on current expectations about reward rates, is modeled by two different decision policies: a learning-independent Win-stay/Lose-shift (WSLS) policy that ignores all previous experiences except the last trial, and Softmax, which prefers the arm with the higher expected reward. To model the learning component for the Softmax choice policy, we use a Bayesian inference model, which updates estimated reward rates based on the observed history of trial outcomes. Softmax with Bayesian learning better fits the behavior of 55% of the participants, while the others are better fit by a learning-independent WSLS strategy. Among Softmax "users", those with higher anhedonia are less likely to choose the option estimated to be most rewarding. Moreover, the Softmax parameter mediates the inverse relationship between anhedonia and overall monetary gains. On the other hand, among WSLS "users", higher state anxiety correlates with increasingly better ability of WSLS, relative to Softmax, to explain subjects' trial-by-trial choices. In summary, there is significant variability among individuals in their reward-based, exploratory decision-making, and this variability is at least partly mediated in a very specific manner by affective attributes, such as hedonic tone and state anxiety.
[Mh] Termos MeSH primário: Anedonia
Ansiedade/psicologia
Tomada de Decisões
Depressão/psicologia
Recompensa
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171024
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186473


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[PMID]:28617831
[Au] Autor:Chiu PY; Wang CW; Tsai CT; Li SH; Lin CL; Lai TJ
[Ad] Endereço:Department of Neurology, Show Chwan Memorial Hospital, Changhua, Taiwan.
[Ti] Título:Depression in dementia with Lewy bodies: A comparison with Alzheimer's disease.
[So] Source:PLoS One;12(6):e0179399, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Depression is highly associated with dementia, and this study will compare the frequencies, severity, and symptoms of depression between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). METHODS: Frequency of depression was determined according to the DSM-IV criteria for major depression or the National Institute of Mental Health criteria for depression in AD (NIMH-dAD). Severity of depression were assessed using the Hamilton Depression Rating Scale, the Cornell Scale for Depression in Dementia, and the depression subscale in Neuropsychiatric Inventory. The rates of depressive symptoms were compared between AD and DLB. RESULTS: A total of 312 patients were investigated (AD/DLB = 241/71). The frequency of major depression was significantly higher (p = 0.017) in DLB (19.7%) than in AD (8.7%). The higher frequency of depression in DLB was not reproduced by using the NIMH-dAD criteria (DLB: AD = 43.7%: 33.2%; p = 0.105). The severity of depression was higher in DLB than in AD according to the Hamilton Depression Rating Scale (p < 0.001) and the Cornell Scale for Depression in Dementia (p < 0.001). Among depressive symptoms, pervasive anhedonia had the highest odds ratio in DLB compared with AD. CONCLUSION: This is the first study using the NIMH-dAD criteria to investigate the frequency of depression in DLB. Our study shows that co-morbid major depression is more frequent in DLB than in AD. Pervasive anhedonia had the greatest value for the differential diagnosis of depression between DLB and AD.
[Mh] Termos MeSH primário: Doença de Alzheimer
Anedonia
Depressão
Doença por Corpos de Lewy
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/diagnóstico
Doença de Alzheimer/fisiopatologia
Doença de Alzheimer/psicologia
Depressão/diagnóstico
Depressão/fisiopatologia
Depressão/psicologia
Feminino
Seres Humanos
Doença por Corpos de Lewy/diagnóstico
Doença por Corpos de Lewy/fisiopatologia
Doença por Corpos de Lewy/psicologia
Masculino
Meia-Idade
Taiwan
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179399


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[PMID]:28581544
[Au] Autor:Chodkiewicz J; Miniszewska J; Strzelczyk D; Gasior K
[Ad] Endereço:Zaklad Psychologii Zdrowia, Instytut Psychologii UL.
[Ti] Título:Polish Adaptation of the Psychache Scale by Ronald Holden and Co-workers.
[Ti] Título:Polska adaptacja Skali Bólu Psychicznego Ronalda Holdena i wspólpracowników..
[So] Source:Psychiatr Pol;51(2):369-381, 2017 Apr 30.
[Is] ISSN:2391-5854
[Cp] País de publicação:Poland
[La] Idioma:eng; pol
[Ab] Resumo:OBJECTIVES: The conducted study was aimed at making a Polish adaptation of the Scale of Psychache by Ronald Holden and co-workers. The scale is a self-assessment method which comprises 13 statements and is designed to assess subjectively experienced psychological pain. METHODS: 300 persons were examined - undergraduates and postgraduates of the University of Lodz and the Technical University of Lodz. The group of the study participants consisted of 185 women and 115 men. Moreover, there were examined 150 alcohol addicted men, 50 co-addicted women and 50 major depressive episode (MDE) patients. RESULTS: The Polish version of the Scale is a reliable and valid tool. The exploratory and confirmatory factor analysis has proved the existence of one factor. The internal consistency, assessed on the basis of Cronbach's alpha, equalled 0.93. The method displays positive and statistically significant relationships to levels of depression, hopelessness, anxiety, anhedonia and negative relations to levels of optimism, life satisfaction, and positive orientation. Alcohol addicted men with presently diagnosed suicidal thoughts were characterised by a significantly higher level of psychological pain as compared to alcoholics without such thoughts. A higher level of psychache was also reported in people with depression who have a history of attempted suicide compared with those who have not attempted suicide. CONCLUSIONS: The effect of the conducted adaptation works on the Psychache Scale speaks for recommending the method for scientific research and use in therapeutic practice.
[Mh] Termos MeSH primário: Sintomas Afetivos/diagnóstico
Ansiedade/diagnóstico
Depressão/diagnóstico
Inquéritos e Questionários/normas
[Mh] Termos MeSH secundário: Adulto
Alcoolismo/diagnóstico
Anedonia
Feminino
Seres Humanos
Masculino
Polônia
Valor Preditivo dos Testes
Psicometria
Reprodutibilidade dos Testes
Ideação Suicida
Suicídio/psicologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


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[PMID]:28399104
[Au] Autor:Kananovich PS; Barkhatova AN
[Ad] Endereço:Mental Health Research Center, Moscow, Russia.
[Ti] Título:[A history and overview of anhedonia in endogenous mental disorders].
[Ti] Título:Évoliutsiia vzgliadov na fenomen angedonii pri éndogennoi psikhicheskoi patologii..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(3):96-101, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Anhedonia is the inability to experience pleasure. This disorder is heterogeneous across psychiatric disorders and is difficult for measuring and submitting to scientific analysis. Over the last several decades there has been increasing interest in the role that anhedonia plays in various psychopathologies. This article reviews the recent literature on anhedonia and its psychopathological features, which are important for prognosis in affective disorders and schizophrenia. Attempts to dissect various subtypes of anhedonia observed in negative syndrome and depression are reviewed as well.
[Mh] Termos MeSH primário: Anedonia
Psicologia do Esquizofrênico
[Mh] Termos MeSH secundário: Depressão/psicologia
Transtorno Depressivo/psicologia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171173196-101


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[PMID]:28336340
[Au] Autor:Faron-Górecka A; Kusmider M; Szafran-Pilch K; Kolasa M; Zurawek D; Gruca P; Papp M; Solich J; Pabian P; Dziedzicka-Wasylewska M
[Ad] Endereço:Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna Street 12, Kraków 31-343, Poland. Electronic address: gorecka@if-pan.krakow.pl.
[Ti] Título:Basal prolactin levels in rat plasma correlates with response to antidepressant treatment in animal model of depression.
[So] Source:Neurosci Lett;647:147-152, 2017 Apr 24.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Prolactin (PRL) has been shown to be altered by psychotropic drugs, including antidepressant drugs (ADs). Many studies have focused on the response to antidepressant treatment (especially related to the serotonergic system) using the fenfluramine test (PRF), however some data suggest lack of correlation between PRF and prediction of clinical response to ADs. In our study we have investigated the hypothesis that basal plasma level of prolactin is a better predictor of antidepressant treatment. We have used Chronic Mild Stress (CMS) - the animal model of depression. Rats are exposed to CMS in combination with imipramine (IMI) treatment for 5 consecutive weeks. Blood samples were collected from the rat tail vein three times: before the CMS procedure, after 2 weeks of stress and after the complete CMS procedure (after 5 weeks of stress and IMI treatment). The PRL level in plasma was determined using the commercially available ELISA kit. In CMS, anhedonia in rats is manifested by reduced consumption of sucrose solution while administration of antidepressant drugs reverses anhedonia. Some animals (ca.30%) did not respond to antidepressant therapy and were considered treatment-resistant. There was no correlation between basal PRL levels and stress response, however, from the results obtained by Spearman Rank Correlation analysis we have observed a significant negative correlation between basal PRL levels before the CMS procedure and behavioral response to IMI administration. The obtained results indicate that the basal PRL level in rat plasma correlates with a good response to treatment in the animal model of depression.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Depressão/tratamento farmacológico
Imipramina/uso terapêutico
Prolactina/sangue
[Mh] Termos MeSH secundário: Anedonia/efeitos dos fármacos
Animais
Depressão/sangue
Depressão/psicologia
Masculino
Ratos
Estresse Psicológico/sangue
Estresse Psicológico/tratamento farmacológico
Estresse Psicológico/psicologia
Sacarose/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 57-50-1 (Sucrose); 9002-62-4 (Prolactin); OGG85SX4E4 (Imipramine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28334960
[Au] Autor:Rothkirch M; Tonn J; Köhler S; Sterzer P
[Ad] Endereço:Visual Perception Laboratory, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Neural mechanisms of reinforcement learning in unmedicated patients with major depressive disorder.
[So] Source:Brain;140(4):1147-1157, 2017 Apr 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:According to current concepts, major depressive disorder is strongly related to dysfunctional neural processing of motivational information, entailing impairments in reinforcement learning. While computational modelling can reveal the precise nature of neural learning signals, it has not been used to study learning-related neural dysfunctions in unmedicated patients with major depressive disorder so far. We thus aimed at comparing the neural coding of reward and punishment prediction errors, representing indicators of neural learning-related processes, between unmedicated patients with major depressive disorder and healthy participants. To this end, a group of unmedicated patients with major depressive disorder (n = 28) and a group of age- and sex-matched healthy control participants (n = 30) completed an instrumental learning task involving monetary gains and losses during functional magnetic resonance imaging. The two groups did not differ in their learning performance. Patients and control participants showed the same level of prediction error-related activity in the ventral striatum and the anterior insula. In contrast, neural coding of reward prediction errors in the medial orbitofrontal cortex was reduced in patients. Moreover, neural reward prediction error signals in the medial orbitofrontal cortex and ventral striatum showed negative correlations with anhedonia severity. Using a standard instrumental learning paradigm we found no evidence for an overall impairment of reinforcement learning in medication-free patients with major depressive disorder. Importantly, however, the attenuated neural coding of reward in the medial orbitofrontal cortex and the relation between anhedonia and reduced reward prediction error-signalling in the medial orbitofrontal cortex and ventral striatum likely reflect an impairment in experiencing pleasure from rewarding events as a key mechanism of anhedonia in major depressive disorder.
[Mh] Termos MeSH primário: Transtorno Depressivo Maior/psicologia
Aprendizagem
Reforço (Psicologia)
[Mh] Termos MeSH secundário: Adulto
Anedonia
Transtorno Depressivo Maior/fisiopatologia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Córtex Pré-Frontal/fisiopatologia
Escalas de Graduação Psiquiátrica
Desempenho Psicomotor
Punição
Recompensa
Estriado Ventral/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx025



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