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Pesquisa : C10.597.606.150.500.300.200.100 [Categoria DeCS]
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[PMID]:27422538
[Au] Autor:Cohen L; Dehaene S; McCormick S; Durant S; Zanker JM
[Ad] Endereço:Inserm, U 1127, F-75013 Paris, France; Sorbonne Universités, UPMC University, Paris 06, UMR S 1127, F-75013 Paris, France; AP-HP, Hôpital de la Pitié Salpêtrière, Department of Neurology, F-75013 Paris, France; CNRS, UMR 7225, F-75013 Paris, France; Institut du Cerveau et de la Moelle épinière, ICM,
[Ti] Título:Brain mechanisms of recovery from pure alexia: A single case study with multiple longitudinal scans.
[So] Source:Neuropsychologia;91:36-49, 2016 Oct.
[Is] ISSN:1873-3514
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pure alexia is an acquired reading disorder, typically due to a left occipito-temporal lesion affecting the Visual Word Form Area (VWFA). It is unclear whether the VWFA acts as a unique bottleneck for reading, or whether alternative routes are available for recovery. Here, we address this issue through the single-case longitudinal study of a neuroscientist who experienced pure alexia and participated in 17 behavioral, 9 anatomical, and 9 fMRI assessment sessions over a period of two years. The origin of the impairment was assigned to a small left fusiform lesion, accompanied by a loss of VWFA responsivity and by the degeneracy of the associated white matter pathways. fMRI experiments allowed us to image longitudinally the visual perception of words, as compared to other classes of stimuli, as well as the mechanisms of letter-by-letter reading. The progressive improvement of reading was not associated with the re-emergence of a new area selective to words, but with increasing responses in spared occipital cortex posterior to the lesion and in contralateral right occipital cortex. Those regions showed a non-specific increase of activations over time and an increase in functional correlation with distant language areas. Those results confirm the existence of an alternative occipital route for reading, bypassing the VWFA, but they also point to its key limitation: the patient remained a slow letter-by-letter reader, thus supporting the critical importance of the VWFA for the efficient parallel recognition of written words.
[Mh] Termos MeSH primário: Alexia Pura/fisiopatologia
Encéfalo/fisiopatologia
Reconhecimento Visual de Modelos/fisiologia
Leitura
Recuperação de Função Fisiológica/fisiologia
[Mh] Termos MeSH secundário: Alexia Pura/diagnóstico por imagem
Alexia Pura/etiologia
Alexia Pura/reabilitação
Encéfalo/diagnóstico por imagem
Seres Humanos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Acidente Vascular Cerebral/complicações
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/fisiopatologia
Reabilitação do Acidente Vascular Cerebral
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170505
[Lr] Data última revisão:
170505
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE


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[PMID]:26970141
[Au] Autor:Petersen A; Vangkilde S; Fabricius C; Iversen HK; Delfi TS; Starrfelt R
[Ad] Endereço:Department of Psychology, University of Copenhagen, Denmark. Electronic address: anders.petersen@psy.ku.dk.
[Ti] Título:Visual attention in posterior stroke and relations to alexia.
[So] Source:Neuropsychologia;92:79-89, 2016 Nov.
[Is] ISSN:1873-3514
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Impaired visual attention is common following strokes in the territory of the middle cerebral artery, particularly in the right hemisphere, while attentional effects of more posterior lesions are less clear. Commonly, such deficits are investigated in relation to specific syndromes like visual agnosia or pure alexia. The aim of this study was to characterize visual processing speed and apprehension span following posterior cerebral artery (PCA) stroke. In addition, the relationship between these attentional parameters and single word reading is investigated, as previous studies have suggested that reduced visual speed and span may explain pure alexia. Eight patients with unilateral PCA strokes (four left hemisphere, four right hemisphere) were selected on the basis of lesion location, rather than the presence of any visual symptoms. Visual attention was characterized by a whole report paradigm allowing for hemifield-specific measurements of processing speed and apprehension span. All patients showed reductions in visual span contralateral to the lesion site, and four patients showed bilateral reductions in visual span despite unilateral lesions (2L; 2R). Six patients showed selective deficits in visual span, though processing speed was unaffected in the same field (ipsi- or contralesionally). Only patients with right hemifield reductions in visual span were impaired in reading, and this could follow either right or left lateralized stroke and was irrespective of visual field impairments. In conclusion, visual span may be affected bilaterally by unilateral PCA-lesions. Reductions in visual span may also be confined to one hemifield, and may be affected in spite of preserved visual processing speed. Furthermore, reduced span in the right visual field seems to be related to reading impairment in this group, regardless of lesion lateralization.
[Mh] Termos MeSH primário: Alexia Pura/etiologia
Atenção
Infarto da Artéria Cerebral Posterior/complicações
Infarto da Artéria Cerebral Posterior/psicologia
Percepção Visual
[Mh] Termos MeSH secundário: Idoso
Alexia Pura/diagnóstico por imagem
Encéfalo/diagnóstico por imagem
Feminino
Lateralidade Funcional
Seres Humanos
Infarto da Artéria Cerebral Posterior/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Testes Neuropsicológicos
Tempo de Reação
Leitura
Testes de Campo Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE


  3 / 87 MEDLINE  
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[PMID]:26397830
[Au] Autor:Robinson JS; Collins RL; Mukhi SV
[Ad] Endereço:a Mental Health Care Line , Michael E. DeBakey Veterans Affairs Medical Center , Houston , Texas.
[Ti] Título:Alexia Without Agraphia in a Right-Handed Individual Following Right Occipital Stroke.
[So] Source:Appl Neuropsychol Adult;23(1):65-9, 2016.
[Is] ISSN:2327-9109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alexia without agraphia is a disconnection syndrome that typically involves damage to the occipital lobe, with splenium involvement, in the dominant left hemisphere. We describe an exceptionally rare case of a right-handed individual displaying this deficit following a right-sided occipital stroke. A report of a single case of a 65-year-old man is presented with data from appointments with the neurology and neuropsychology departments that occurred approximately 10 and 12 months following the patient's stroke. During the evaluation, he exhibited a marked deficit in his ability to read, with vision grossly intact. His ability to write single words and short phrases from dictation was intact, but he was later unable to read them. This case demonstrates the complexity of the organization of language in the human brain. Although a large majority of individuals exhibit language dominance in their left hemispheres, it remains possible that some right-handed individuals may show atypical organization of language. This highlights the need for clinicians to consider atypical cortical organization when observed deficits may not necessarily match expected lesions within the cortex.
[Mh] Termos MeSH primário: Alexia Pura/patologia
Alexia Pura/psicologia
Lobo Occipital/patologia
Acidente Vascular Cerebral/patologia
Acidente Vascular Cerebral/psicologia
[Mh] Termos MeSH secundário: Idoso
Alexia Pura/complicações
Lateralidade Funcional
Seres Humanos
Masculino
Testes Neuropsicológicos
Acidente Vascular Cerebral/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151218
[Lr] Data última revisão:
151218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150924
[St] Status:MEDLINE
[do] DOI:10.1080/23279095.2014.973495


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[PMID]:26745321
[Au] Autor:Johnson RL; Raphail AM
[Ad] Endereço:a Department of Psychology , Neuroscience Program, Skidmore College , Saratoga Springs , NY , USA.
[Ti] Título:Untangling letter confusability and word length effects in pure alexia.
[So] Source:Cogn Neuropsychol;32(7-8):442-56, 2015 Oct-Dec.
[Is] ISSN:1464-0627
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pure alexia is an acquired neuropsychological disorder that follows damage to the occipito-temporal lobe. This brain damage results in a severe reading impairment in which previously literate individuals are no longer able to efficiently read words, but are still able to perform other language tasks. The present study sought to identify factors of words that make it more difficult for pure alexic individuals to read, such as letter confusability and word length. Eye-tracking methodology was paired with a naming task to examine whether word length or letter confusability is a better predictor of processing difficulty. It was found that word length was a significant predictor of reading time, while summed letter confusability was not significant. This study contradicts some previous research and shows that when an orthogonal set of stimuli is used, letter confusability is not a significant factor driving this reading impairment in all individuals with pure alexia.
[Mh] Termos MeSH primário: Alexia Pura/fisiopatologia
Linguagem
Leitura
[Mh] Termos MeSH secundário: Idoso
Movimentos Oculares
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160109
[St] Status:MEDLINE
[do] DOI:10.1080/02643294.2015.1113945


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[PMID]:26211290
[Au] Autor:Nau JY
[Ti] Título:["Alexia without agraphia? So, it was the calcarine sulcus!"].
[Ti] Título:"L'alexie sans agraphie? C'est donc une calcarine"!.
[So] Source:Rev Med Suisse;11(477):1260-1, 2015 Jun 03.
[Is] ISSN:1660-9379
[Cp] País de publicação:Switzerland
[La] Idioma:fre
[Mh] Termos MeSH primário: Autopsia/tendências
Neurologia
[Mh] Termos MeSH secundário: Academias e Institutos/história
Academias e Institutos/tendências
Alexia Pura/patologia
Atitude do Pessoal de Saúde
Autopsia/utilização
Causas de Morte
Patologia Legal
França
História do Século XX
História do Século XXI
Seres Humanos
Neurologia/educação
Neurologia/história
Neurologia/tendências
Lobo Occipital/patologia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; NEWS
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150727
[Lr] Data última revisão:
150727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE


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[PMID]:26110814
[Au] Autor:Kim ES; Rising K; Rapcsak SZ; Beeson PM
[Ti] Título:Treatment for Alexia With Agraphia Following Left Ventral Occipito-Temporal Damage: Strengthening Orthographic Representations Common to Reading and Spelling.
[So] Source:J Speech Lang Hear Res;58(5):1521-37, 2015 Oct.
[Is] ISSN:1558-9102
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Damage to left ventral occipito-temporal cortex can give rise to written language impairment characterized by pure alexia/letter-by-letter (LBL) reading, as well as surface alexia and agraphia. The purpose of this study was to examine the therapeutic effects of a combined treatment approach to address concurrent LBL reading with surface alexia/agraphia. METHOD: Simultaneous treatment to address slow reading and errorful spelling was administered to 3 individuals with reading and spelling impairments after left ventral occipito-temporal damage due to posterior cerebral artery stroke. Single-word reading/spelling accuracy, reading latencies, and text reading were monitored as outcome measures for the combined effects of multiple oral re-reading treatment and interactive spelling treatment. RESULTS: After treatment, participants demonstrated faster and more accurate single-word reading and improved text-reading rates. Spelling accuracy also improved, particularly for untrained irregular words, demonstrating generalization of the trained interactive spelling strategy. CONCLUSION: This case series characterizes concomitant LBL with surface alexia/agraphia and demonstrates a successful treatment approach to address both the reading and spelling impairment.
[Mh] Termos MeSH primário: Agrafia/terapia
Alexia Pura/terapia
Infarto da Artéria Cerebral Posterior/complicações
Terapia da Linguagem/métodos
Lobo Temporal
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Agrafia/etiologia
Alexia Pura/etiologia
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Satisfação do Paciente
Leitura
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150626
[St] Status:MEDLINE
[do] DOI:10.1044/2015_JSLHR-L-14-0286


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[PMID]:26009564
[Au] Autor:Whitlock JB; Robinson GT; Whitlock JP; Dredla BK; Barrett KM
[Ad] Endereço:From the Departments of Neurology (J.B.W., G.T.R., K.M.B.), Radiology (J.P.W.), and Internal Medicine (B.K.D.), Mayo Clinic, Jacksonville, FL.
[Ti] Título:Mystery Case: A 21-year-old man with visual loss following marijuana use.
[So] Source:Neurology;84(21):e165-9, 2015 May 26.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alexia Pura/etiologia
Erros de Diagnóstico
Hemianopsia/etiologia
Infarto da Artéria Cerebral Posterior/complicações
Infarto da Artéria Cerebral Posterior/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Corpo Caloso/patologia
Seres Humanos
Infarto da Artéria Cerebral Posterior/patologia
Masculino
Fumar Maconha/efeitos adversos
Córtex Visual/patologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150526
[Lr] Data última revisão:
150526
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150527
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000001627


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[PMID]:25708175
[Au] Autor:Bao JY; Rubino C; Taylor AJ; Barton JJ
[Ad] Endereço:Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology) and Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, Canada.
[Ti] Título:The effects of homonymous hemianopia in experimental studies of alexia.
[So] Source:Neuropsychologia;70:156-64, 2015 Apr.
[Is] ISSN:1873-3514
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pure alexia is characterized by an increased word-length effect in reading. However, this disorder is usually accompanied by right homonymous hemianopia, which itself can cause a mildly increased word-length effect. Some alexic studies have used hemianopic patients with modest word-length effects: it is not clear (a) whether they had pure alexia and (b) if not, whether their results could be explained by the field defect. Our goal was to determine if impairments in visual processing claimed to be related to alexia could be replicated in homonymous hemianopia alone. Twelve healthy subjects performed five experiments used in two prior studies of alexia, under both normal and simulated hemianopic conditions, using a gaze-contingent display generated by an eye-tracker. We replicated the increased word-length effect for reading time with right homonymous hemianopia, and showed a similar effect for a lexical decision task. Simulated hemianopia impaired scanning accuracy for letter or number strings, and slowed object part processing, though the effect of configuration was not greater under hemianopic viewing. Hemianopia impaired the identification of words whose letters appeared and disappeared sequentially on the screen, with better performance on a cumulative presentation in which the letters remained on the screen. The reporting of trigrams was less accurate with hemianopia, though syllabic structure did not influence the results. We conclude that some impairments that have been attributed to the processing defects underlying alexia may actually be due to right homonymous hemianopia. Our results underline the importance of considering the contribution of accompanying low-level visual impairments when studying high-level processes.
[Mh] Termos MeSH primário: Alexia Pura/complicações
Atenção/fisiologia
Hemianopsia/etiologia
Orientação/fisiologia
Campos Visuais/fisiologia
[Mh] Termos MeSH secundário: Adulto
Alexia Pura/etiologia
Análise de Variância
Tomada de Decisões
Feminino
Fixação Ocular
Seres Humanos
Masculino
Estimulação Luminosa
Leitura
Fatores de Tempo
Vocabulário
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150419
[Lr] Data última revisão:
150419
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150225
[St] Status:MEDLINE


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[PMID]:25700186
[Au] Autor:Mares I; Custodio P; Fonseca J; Bentes C; Guerreiro M; Guimarães N; Pavão Martins I
[Ad] Endereço:a Language Research Laboratory, Institute of Molecular Medicine (IMM), Faculty of Medicine , University of Lisbon (FMUL) , Lisbon , Portugal.
[Ti] Título:To read or not to read: a neurophysiological study.
[So] Source:Neurocase;21(6):793-801, 2015.
[Is] ISSN:1465-3656
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pure alexia (PA) has been associated with visual deficits or a failure to activate the visual word form area (VWFA). We report a patient with pure alexia due to posterior cortical atrophy, in whom event-related potentials revealed a delay in the P100 component and an absent N170 compared with controls. Furthermore, there was a tendency for a larger delay in P100 latencies associated with incorrectly read words. This suggests that some cases of PA might result from deficits in visual perception, signaled by the P100 early potential which could lead to an inability to consistently activate the VWFA, marked by the absent N170.
[Mh] Termos MeSH primário: Alexia Pura/fisiopatologia
Encéfalo/patologia
Encéfalo/fisiopatologia
Leitura
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Alexia Pura/etiologia
Alexia Pura/patologia
Atrofia
Eletroencefalografia
Potenciais Evocados Visuais
Feminino
Seres Humanos
Masculino
Meia-Idade
Lobo Occipital/patologia
Lobo Occipital/fisiopatologia
Lobo Parietal/patologia
Lobo Parietal/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150822
[Lr] Data última revisão:
150822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150221
[St] Status:MEDLINE
[do] DOI:10.1080/13554794.2015.1013137


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[PMID]:25511797
[Au] Autor:Lacey EH; Jiang X; Friedman RB; Snider SF; Parra LC; Huang Y; Turkeltaub PE
[Ad] Endereço:Department of Neurology, Georgetown University, 4000 Reservoir Road, NW Building D, 165, Washington, DC 20057, USA; MedStar National Rehabilitation Hospital, USA. Electronic address: EHL4@georgetown.edu.
[Ti] Título:Transcranial direct current stimulation for pure alexia: effects on brain and behavior.
[So] Source:Brain Stimul;8(2):305-7, 2015 Mar-Apr.
[Is] ISSN:1876-4754
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alexia Pura/terapia
Córtex Cerebral/fisiologia
Estimulação Transcraniana por Corrente Contínua
[Mh] Termos MeSH secundário: Idoso
Mapeamento Encefálico
Terapia Combinada
Seres Humanos
Terapia da Linguagem
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; LETTER; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1505
[Cu] Atualização por classe:160518
[Lr] Data última revisão:
160518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141217
[St] Status:MEDLINE



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