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[PMID]:29204259
[Au] Autor:Kolesnik AM; Jones EJH; Garg S; Green J; Charman T; Johnson MH; EDEN-BASIS Team;
[Ad] Endereço:Centre for Brain and Cognitive Development and Department of Psychology, Birkbeck, University of London, Malet Street, London, WC1E 7HX UK.
[Ti] Título:Early development of infants with neurofibromatosis type 1: a case series.
[So] Source:Mol Autism;8:62, 2017.
[Is] ISSN:2040-2392
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: Prospective studies of infants at familial risk for autism spectrum disorder (ASD) have yielded insights into the earliest signs of the disorder but represent heterogeneous samples of unclear aetiology. Complementing this approach by studying cohorts of infants with monogenic syndromes associated with high rates of ASD offers the opportunity to elucidate the factors that lead to ASD. Methods: We present the first report from a prospective study of ten 10-month-old infants with neurofibromatosis type 1 (NF1), a monogenic disorder with high prevalence of ASD or ASD symptomatology. We compared data from infants with NF1 to a large cohort of infants at familial risk for ASD, separated by outcome at age 3 of ASD ( = 34), atypical development ( = 44), or typical development ( = 89), and low-risk controls ( = 75). Domains assessed at 10 months by parent report and examiner observation include cognitive and adaptive function, sensory processing, social engagement, and temperament. Results: Infants with NF1 showed striking impairments in motor functioning relative to low-risk infants; this pattern was seen in infants with later ASD from the familial cohort (HR-ASD). Both infants with NF1 and the HR-ASD group showed communication delays relative to low-risk infants. Conclusions: Ten-month-old infants with NF1 show a range of developmental difficulties that were particularly striking in motor and communication domains. As with HR-ASD infants, social skills at this age were not notably impaired. This is some of the first information on early neurodevelopment in NF1. Strong inferences are limited by the sample size, but the findings suggest implications for early comparative developmental science and highlight motor functioning as an important domain to inform the development of relevant animal models. The findings have clinical implications in indicating an important focus for early surveillance and remediation in this early diagnosed genetic disorder.
[Mh] Termos MeSH primário: Neurofibromatose 1/diagnóstico
[Mh] Termos MeSH secundário: Atividades Cotidianas
Transtorno do Espectro Autista/etiologia
Cognição
Comunicação
Feminino
Seres Humanos
Lactente
Transtornos do Desenvolvimento da Linguagem/complicações
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Masculino
Atividade Motora
Neurofibromatose 1/complicações
Estudos Prospectivos
Risco
Temperamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1186/s13229-017-0178-0


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[PMID]:29173713
[Au] Autor:Capone Singleton N
[Ad] Endereço:Department of Speech-Language Pathology, School of Health and Medical Sciences, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA. Electronic address: nina.capone@shu.edu.
[Ti] Título:Late Talkers: Why the Wait-and-See Approach Is Outdated.
[So] Source:Pediatr Clin North Am;65(1):13-29, 2018 Feb.
[Is] ISSN:1557-8240
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:From a speech-language pathology perspective, there is a gap in interprofessional education/practice (IPE/IPP) that leads to a wait-and-see approach with late talkers (LT). In line with the American Speech-Language-Hearing Association's Strategic Pathway to Excellence, this article attempts to bridge the gap, reexamining the panoptic view that most LT "catch up" to their peers. The LT who persist with language disorder should not be overlooked. Late talking can impact socialization and school readiness, and can place some toddlers at risk for life-long disability. Each state's early intervention program has an established IPP infrastructure. Parent-implemented intervention addresses risks and maximizes protective factors.
[Mh] Termos MeSH primário: Intervenção Precoce (Educação)
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Transtornos do Desenvolvimento da Linguagem/terapia
Terapia da Linguagem
Encaminhamento e Consulta
Conduta Expectante
[Mh] Termos MeSH secundário: Pré-Escolar
Seres Humanos
Lactente
Transtornos do Desenvolvimento da Linguagem/etiologia
Programas de Rastreamento
Pais
Equipe de Assistência ao Paciente
Pediatria
Medição de Risco
Fatores de Risco
Patologia da Fala e Linguagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29054980
[Au] Autor:Hampton LH; Kaiser AP; Roberts MY
[Ad] Endereço:Vanderbilt University, Nashville, Tennessee; and lauren.hampton@northwestern.edu.
[Ti] Título:One-Year Language Outcomes in Toddlers With Language Delays: An RCT Follow-up.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. METHODS: Toddlers with language delays were recruited from the community, and 97 toddlers and parents were randomly assigned to receive usual community treatments or a 3-month EMT intervention with parent training. Multiple regression analyses were used to estimate the differences between groups at the 6- and 12-month follow-up periods. A subgroup of participants with receptive and expressive language delays was used in a post hoc moderator analysis of treatment outcomes. RESULTS: Children in the treatment arm did not differ from children in the control arm at 6- and 12-month follow-ups. However, post hoc analyses revealed that children with receptive-expressive language delays were persistently delayed relative to normative performance throughout the follow-up period. CONCLUSIONS: The immediate effects of the brief delivery of EMT were not sustained over the 1-year follow-up period. However, the short-term intervention may not have been sufficient for children with receptive-expressive delays to develop typical language abilities, suggesting they may need more intensive early intervention. Although this intervention may not be necessary for all children with primary language delays, future research should determine the extent to which children with receptive-expressive delays may benefit from more intensive intervention.
[Mh] Termos MeSH primário: Transtornos do Desenvolvimento da Linguagem/diagnóstico
Transtornos do Desenvolvimento da Linguagem/terapia
Terapia da Linguagem/métodos
Terapia da Linguagem/tendências
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171022
[St] Status:MEDLINE


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[PMID]:28942966
[Au] Autor:Stankiewicz P; Khan TN; Szafranski P; Slattery L; Streff H; Vetrini F; Bernstein JA; Brown CW; Rosenfeld JA; Rednam S; Scollon S; Bergstrom KL; Parsons DW; Plon SE; Vieira MW; Quaio CRDC; Baratela WAR; Acosta Guio JC; Armstrong R; Mehta SG; Rump P; Pfundt R; Lewandowski R; Fernandes EM; Shinde DN; Tang S; Hoyer J; Zweier C; Reis A; Bacino CA; Xiao R; Breman AM; Smith JL; Katsanis N; Bostwick B; Popp B; Davis EE; Yang Y; Deciphering Developmental Disorders Study
[Ad] Endereço:Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Baylor Genetics, Houston, TX 77021, USA. Electronic address: pawels@bcm.edu.
[Ti] Título:Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.
[So] Source:Am J Hum Genet;101(4):503-515, 2017 Oct 05.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bromodomain PHD finger transcription factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISWI chromatin-remodeling complex. However, the clinical consequences of disruption of this complex remain largely uncharacterized. BPTF is required for anterior-posterior axis formation of the mouse embryo and was shown to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 expression in zebrafish. Here, we report eight loss-of-function and two missense variants (eight de novo and two of unknown origin) in BPTF on 17q24.2. The BPTF variants were found in unrelated individuals aged between 2.1 and 13 years, who manifest variable degrees of developmental delay/intellectual disability (10/10), speech delay (10/10), postnatal microcephaly (7/9), and dysmorphic features (9/10). Using CRISPR-Cas9 genome editing of bptf in zebrafish to induce a loss of gene function, we observed a significant reduction in head size of F0 mutants compared to control larvae. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and phospho-histone H3 (PH3) staining to assess apoptosis and cell proliferation, respectively, showed a significant increase in cell death in F0 mutants compared to controls. Additionally, we observed a substantial increase of the ceratohyal angle of the craniofacial skeleton in bptf F0 mutants, indicating abnormal craniofacial patterning. Taken together, our data demonstrate the pathogenic role of BPTF haploinsufficiency in syndromic neurodevelopmental anomalies and extend the clinical spectrum of human disorders caused by ablation of chromatin remodeling complexes.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/genética
Antígenos Nucleares/genética
Anormalidades Craniofaciais/genética
Regulação da Expressão Gênica no Desenvolvimento
Haploinsuficiência/genética
Transtornos do Desenvolvimento da Linguagem/genética
Microcefalia/genética
Proteínas do Tecido Nervoso/genética
Fatores de Transcrição/genética
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/patologia
Adolescente
Animais
Antígenos Nucleares/metabolismo
Sistemas CRISPR-Cas
Proliferação Celular
Células Cultivadas
Criança
Pré-Escolar
Montagem e Desmontagem da Cromatina
Estudos de Coortes
Anormalidades Craniofaciais/patologia
Feminino
Edição de Genes
Haploinsuficiência/fisiologia
Seres Humanos
Transtornos do Desenvolvimento da Linguagem/patologia
Larva/genética
Larva/crescimento & desenvolvimento
Masculino
Microcefalia/patologia
Proteínas do Tecido Nervoso/antagonistas & inibidores
Proteínas do Tecido Nervoso/metabolismo
Neurônios/metabolismo
Neurônios/patologia
Fenótipo
Fatores de Transcrição/antagonistas & inibidores
Fatores de Transcrição/metabolismo
Peixe-Zebra/genética
Peixe-Zebra/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Nuclear); 0 (Nerve Tissue Proteins); 0 (Transcription Factors); 0 (fetal Alzheimer antigen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


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[PMID]:28902228
[Au] Autor:Fattore IM; Uhde RM; Oliveira LD; Roth AM; Souza APR
[Ad] Endereço:Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.
[Ti] Título:Comparative analysis of initial vocalizations of preterm and full-term infants with and without risk for development.
[Ti] Título:Análise comparativa das vocalizações iniciais de bebês prematuros e a termo, com e sem risco ao desenvolvimento..
[So] Source:Codas;29(4):e20160075, 2017 Aug 24.
[Is] ISSN:2317-1782
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Ab] Resumo:Purpose: To compare the evolution of vocalization in preterm and full-term infants, with and without risk for development, analyzing the possible association of sociodemographic, obstetric and psychosocial variables with vocalization. Methods: The study sample consisted of 30 infants, aged 3 months and 1 day to 4 months and 29 days (Phase 1) and 6 months and 1 day to 7 months and 29 days (Phase 2), of both genders, with gestational age <37 weeks (preterm group) and >37 weeks (full-term group). The following instruments were used for data collection: Child Development Risk Indicators (IRDl), the Denver II Test, an interview on the experience of motherhood with sociodemographic, obstetric and psychosocial data, as well as filming of the mother-infant dyad at the two phases of the research. Footage was analyzed using the EUDICO Linguistic Annotator (ELAN) software and the results were statistically analyzed on the STATISTICA 9.0 software. Results: The larger the total number of Phase II infants' and mothers' vocalizations using motherese, the greater the number of IRDls present. Significant increase in vocalizations without motherese was also observed in Phase 2. Sociodemographic variables, gestational age, weight at birth, maternal schooling, and the Brazil Criterion did not directly affect the infants' vocalization level. Conclusion: Analysis of the infants' vocalizations was sensitive to risk development and Child Development Risk Indicators in Phase 1; the Denver-language test was more effective in Phase 2. No influence of the sociodemographic variables was observed in the phases studied.
[Mh] Termos MeSH primário: Linguagem Infantil
Comportamento Verbal
[Mh] Termos MeSH secundário: Brasil
Escolaridade
Feminino
Idade Gestacional
Seres Humanos
Lactente
Recém-Nascido
Recém-Nascido Prematuro
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Masculino
Relações Mãe-Filho
Gravidez
Fatores de Risco
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE


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[PMID]:28841425
[Au] Autor:Lee JC
[Ad] Endereço:Department of Communication Sciences and Disorders, University of Iowa, Iowa City 52242, USA. Electronic address: joannachen-lee@uiowa.edu.
[Ti] Título:Insensitivity to response-contingent feedback in adolescents with developmental language disorder (DLD).
[So] Source:Brain Lang;174:112-118, 2017 Nov.
[Is] ISSN:1090-2155
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to investigate the efficiency of the use of response-contingent feedback in adolescents with and without developmental language disorder (DLD) by using the balloon analogue risk task (BART). The BIS/BAS scales were also used to evaluate a participant's responses to reward- or punishment-related events in everyday situations. The results showed that adolescents with DLD performed on the BART at a suboptimal level due to inefficient use of response-contingent feedback. Findings of the BIS/BAS scales also generate a possible hypothesis of reduced motivational salience for larger monetary outcomes in DLD. Given that dopamine plays an important role in modulating BART responding through the corticostriatal pathways, these behavioral findings implicate an association between dopamine and individual differences in language, including DLD. Future studies are needed to directly test whether people with DLD have reduced level of dopamine in striatal neural synapses, leading to dopamine-dependent learning difficulty.
[Mh] Termos MeSH primário: Retroalimentação Psicológica
Transtornos do Desenvolvimento da Linguagem/fisiopatologia
Transtornos do Desenvolvimento da Linguagem/psicologia
[Mh] Termos MeSH secundário: Adolescente
Corpo Estriado/citologia
Corpo Estriado/metabolismo
Dopamina/metabolismo
Feminino
Seres Humanos
Individualidade
Masculino
Punição
Recompensa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


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[PMID]:28814537
[Au] Autor:Raspa M; Wheeler AC; Riley C
[Ad] Endereço:RTI International, Research Triangle Park, North Carolina; and mraspa@rti.org.
[Ti] Título:Public Health Literature Review of Fragile X Syndrome.
[So] Source:Pediatrics;139(Suppl 3):S153-S171, 2017 Jun.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this systematic literature review is to describe what is known about fragile X syndrome (FXS) and to identify research gaps. The results can be used to help inform future public health research and provide pediatricians with up-to-date information about the implications of the condition for individuals and their families. METHODS: An electronic literature search was conducted, guided by a variety of key words. The search focused on 4 areas of both clinical and public health importance: (1) the full mutation phenotype, (2) developmental trajectories across the life span, (3) available interventions and treatments, and (4) impact on the family. A total of 661 articles were examined and 203 were included in the review. RESULTS: The information is presented in the following categories: developmental profile (cognition, language, functional skills, and transition to adulthood), social-emotional profile (cooccurring psychiatric conditions and behavior problems), medical profile (physical features, seizures, sleep, health problems, and physiologic features), treatment and interventions (educational/behavioral, allied health services, and pharmacologic), and impact on the family (family environment and financial impact). Research gaps also are presented. CONCLUSIONS: The identification and treatment of FXS remains an important public health and clinical concern. The information presented in this article provides a more robust understanding of FXS and the impact of this complex condition for pediatricians. Despite a wealth of information about the condition, much work remains to fully support affected individuals and their families.
[Mh] Termos MeSH primário: Síndrome do Cromossomo X Frágil/genética
Saúde Pública
[Mh] Termos MeSH secundário: Adulto
Cuidadores/psicologia
Criança
Estudos Transversais
Análise Mutacional de DNA
Assistência à Saúde
Deficiências do Desenvolvimento/diagnóstico
Deficiências do Desenvolvimento/genética
Diagnóstico Diferencial
Feminino
Proteína do X Frágil de Retardo Mental/genética
Síndrome do Cromossomo X Frágil/diagnóstico
Síndrome do Cromossomo X Frágil/psicologia
Síndrome do Cromossomo X Frágil/terapia
Testes Genéticos
Seres Humanos
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Transtornos do Desenvolvimento da Linguagem/genética
Transtornos do Desenvolvimento da Linguagem/psicologia
Transtornos do Desenvolvimento da Linguagem/terapia
Masculino
Poder Familiar/psicologia
Fenótipo
Prognóstico
Ajustamento Social
Repetições de Trinucleotídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (FMR1 protein, human); 139135-51-6 (Fragile X Mental Retardation Protein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1542/peds.2016-1159C


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[PMID]:28813074
[Au] Autor:Ganthous G; Rossi NF; Giacheti CM
[Ad] Endereço:Universidade Estadual Paulista - UNESP - Marília (SP), Brasil.
[Ti] Título:Oral narrative of individuals with Fetal Alcohol Spectrum Disorder.
[Ti] Título:Narrativa oral de indivíduos com Transtorno do Espectro Alcoólico Fetal..
[So] Source:Codas;29(4):e20170012, 2017 Aug 10.
[Is] ISSN:2317-1782
[Cp] País de publicação:Brazil
[La] Idioma:por; eng
[Ab] Resumo:Purpose: To investigate and compare the oral narrative of individuals with FASD and individuals with typical language development (TLD), as well as to correlate the narrative performance with the score from 4-Digit Diagnostic Code. Methods: Participants were 20 individuals with FASD, of both genders, with chronological age between 6 and 16 years, and 20 individuals with TLD, same gender and similar to the FASD group in age and socioeconomic status. The oral narrative was elicited using the book Frog, where are you? and the data were analyzed in terms of macrostructure, microstructure and global coherence level. Measures regarding the macrostructure included the presence of typical structural elements of storytelling, while the microstructural aspects included words (total and different words), communication units (C-Units), lexical diversity, and mean length of C-Units. Results: Low performance was found in the FASD group for all macrostructural aspects, with the exception of linguistic markers. Among the microstructural aspects, lexical diversity and incomplete C-Units were different between the FASD and TLD groups. The FASD group presented lower global coherence level compared to the TLD group. Negative correlations were found between macrostructural aspects, facial characteristics, and Central Nervous System impairment. Conclusion: Restricted use of typical structural elements of storytelling with lower levels of coherence and reduced vocabulary distinguished the FASD from the TDL group. Future studies may explore whether the association between narrative performance and the 4-Digit Diagnostic Code items present predictive values in the narrative performance of individuals with FASD.
[Mh] Termos MeSH primário: Transtornos do Espectro Alcoólico Fetal/diagnóstico
Transtornos do Espectro Alcoólico Fetal/fisiopatologia
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Transtornos do Desenvolvimento da Linguagem/fisiopatologia
Narração
[Mh] Termos MeSH secundário: Adolescente
Doenças do Sistema Nervoso Central/fisiopatologia
Criança
Feminino
Transtornos do Crescimento/fisiopatologia
Seres Humanos
Testes de Linguagem
Masculino
Valor Preditivo dos Testes
Valores de Referência
Estatísticas não Paramétricas
Vocabulário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


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[PMID]:28802387
[Au] Autor:de Castro Corrêa C; José MR; Andrade EC; Feniman MR; Fukushiro AP; Berretin-Felix G; Maximino LP
[Ad] Endereço:Department of Ophthalmology, Otolaryngology and Head and Neck Surgery, Botucatu Medical School, State University São Paulo, UNESP, Botucatu, SP, Brazil. Electronic address: camila.ccorrea@hotmail.com.
[Ti] Título:Sleep quality and communication aspects in children.
[So] Source:Int J Pediatr Otorhinolaryngol;100:57-61, 2017 Sep.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To correlate quality of life of children in terms of sleep, with their oral language skills, auditory processing and orofacial myofunctional aspects. METHODS: Nineteen children (12 males and seven females, in the mean age 9.26) undergoing otorhinolaryngological and speech evaluations participated in this study. The OSA-18 questionnaire was applied, followed by verbal and nonverbal sequential memory tests, dichotic digit test, nonverbal dichotic test and Sustained Auditory Attention Ability Test, related to auditory processing. The Phonological Awareness Profile test, Rapid Automatized Naming and Phonological Working Memory were used for assessment of the phonological processing. Language was assessed by the ABFW Child Language Test, analyzing the phonological and lexical levels. Orofacial myofunctional aspects were evaluated through the MBGR Protocol. Statistical tests used: the Mann-Whitney Test, Fisher's exact test and Spearman Correlation. RESULTS: Relating the performance of children in all evaluations to the results obtained in the OSA-18, there was a statistically significant correlation in the phonological working memory for backward digits (p = 0.04); as well as in the breathing item (p = 0.03), posture of the mandible (p = 0.03) and mobility of lips (p = 0.04). CONCLUSION: A correlation was seen between the sleep quality of life and the skills related to the phonological processing, specifically in the phonological working memory in backward digits, and related to orofacial myofunctional aspects.
[Mh] Termos MeSH primário: Linguagem Infantil
Transtornos do Desenvolvimento da Linguagem/etiologia
Memória de Curto Prazo/fisiologia
Qualidade de Vida
Sono/fisiologia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Comunicação
Feminino
Seres Humanos
Testes de Linguagem
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


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[PMID]:28786484
[Au] Autor:Cunningham BJ; Hanna SE; Oddson B; Thomas-Stonell N; Rosenbaum P
[Ad] Endereço:School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
[Ti] Título:A population-based study of communicative participation in preschool children with speech-language impairments.
[So] Source:Dev Med Child Neurol;59(10):1049-1055, 2017 Oct.
[Is] ISSN:1469-8749
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: To develop statistical models of communicative participation development of preschool children and explore variations by level of function. METHOD: This was a secondary analysis of data from a longitudinal study of preschool children with speech and language impairments (n=46 872; age range 18-67mo, mean age [SD] 41.76mo [11.92]; 67% male) accessing publicly funded services in Ontario, Canada. Two measures were used: Focus on the Outcomes of Communication Under Six (FOCUS), measuring changes in communicative participation skills, and the Communication Function Classification System (CFCS), classifying communicative function into one of five levels. We used mixed effects modeling to fit growth curves for children in each CFCS level. Models allowed for variation in initial FOCUS score at 18 months, rate of growth with age, and rate of acceleration/deceleration with age. RESULTS: Starting FOCUS score (18mo) varied inversely with CFCS level at entry to the program. Growth was initially rapid and then leveled off for children in Levels I to III. Growth was less rapid for children in Level IV, but leveled off, and was slow but continual for children in Level V. INTERPRETATION: This work can help us to move beyond traditional impairment-based thinking and shows that children can make meaningful communicative changes regardless of their function.
[Mh] Termos MeSH primário: Comunicação
Transtornos do Desenvolvimento da Linguagem
Distúrbios da Fala
[Mh] Termos MeSH secundário: Desenvolvimento Infantil
Pré-Escolar
Feminino
Seres Humanos
Lactente
Testes de Linguagem
Estudos Longitudinais
Masculino
Ontário
Estudos Prospectivos
Habilidades Sociais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1111/dmcn.13515



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